psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A135	R:R:Y138	4	No	No	0	3	5
2	R:R:M137	R:R:Y138	3.59	No	No	0	4	5
3	R:R:F141	R:R:M137	3.73	Yes	No	0	6	4
4	R:R:F141	R:R:S140	3.96	Yes	No	0	6	4
5	R:R:F141	R:R:F383	11.79	Yes	Yes	0	6	5
6	R:R:F141	R:R:L386	6.09	Yes	No	0	6	7
7	R:R:Q142	R:R:Y145	13.53	No	Yes	0	5	7
8	R:R:F383	R:R:M144	4.98	Yes	No	4	5	6
9	R:R:F387	R:R:M144	3.73	Yes	No	4	5	6
10	R:R:T146	R:R:Y145	6.24	No	Yes	0	7	7
11	R:R:D195	R:R:Y145	10.34	Yes	Yes	0	7	7
12	R:R:L386	R:R:Y145	5.86	No	Yes	0	7	7
13	R:R:S390	R:R:Y145	2.54	No	Yes	0	9	7
14	R:R:F391	R:R:G148	9.03	Yes	No	0	7	7
15	R:R:S152	R:R:Y149	2.54	No	Yes	0	9	8
16	R:R:K187	R:R:Y149	5.97	No	Yes	0	8	8
17	R:R:V191	R:R:Y149	20.19	Yes	Yes	0	7	8
18	R:R:S390	R:R:Y149	8.9	No	Yes	0	9	8
19	R:R:L153	R:R:L157	2.77	Yes	No	0	6	3
20	R:R:A188	R:R:L153	4.73	No	Yes	0	8	6
21	R:R:F181	R:R:L156	4.87	Yes	Yes	1	8	8
22	R:R:F184	R:R:L156	6.09	Yes	Yes	1	8	8
23	R:R:L156	R:R:V185	4.47	Yes	No	0	8	8
24	R:R:G393	R:R:L156	3.42	No	Yes	1	9	8
25	R:R:L157	R:R:V185	2.98	No	No	0	3	8
26	R:R:F402	R:R:L158	6.09	No	No	0	9	5
27	R:R:A159	R:R:F181	2.77	No	Yes	1	9	8
28	R:R:A159	R:R:C401	3.61	No	Yes	1	9	9
29	R:R:F181	R:R:L160	6.09	Yes	No	0	8	6
30	R:R:C401	R:R:I162	3.27	Yes	No	0	9	8
31	R:R:I162	R:R:L411	2.85	No	No	0	8	5
32	R:R:L163	R:R:N174	4.12	Yes	No	1	8	9
33	R:R:F181	R:R:L163	2.44	Yes	Yes	1	8	8
34	R:R:C401	R:R:L163	3.17	Yes	Yes	1	9	8
35	R:R:E410	R:R:L166	6.63	No	No	0	8	7
36	R:R:L166	R:R:R414	7.29	No	No	0	7	5
37	R:R:E410	R:R:S167	4.31	No	No	0	8	8
38	R:R:R414	R:R:S167	2.64	No	No	0	5	8
39	R:R:E406	R:R:K168	2.7	Yes	No	0	9	8
40	R:R:H170	R:R:L169	9	No	No	0	7	9
41	R:R:C171	R:R:R173	5.57	No	No	1	7	9
42	R:R:C171	R:R:N174	3.15	No	No	1	7	9
43	R:R:T172	R:R:Y248	11.24	No	Yes	0	7	8
44	R:R:S262	R:R:T172	6.4	No	No	0	5	7
45	R:R:N174	R:R:R173	6.03	No	No	1	9	9
46	R:R:H177	R:R:R173	6.77	No	No	0	9	9
47	R:R:A175	R:R:F264	4.16	No	Yes	0	6	6
48	R:R:I176	R:R:W241	4.7	Yes	Yes	0	9	9
49	R:R:E245	R:R:I176	5.47	No	Yes	0	9	9
50	R:R:I176	R:R:Y248	6.04	Yes	Yes	0	9	8
51	R:R:F264	R:R:I176	2.51	Yes	Yes	0	6	9
52	R:R:E245	R:R:H177	13.54	No	No	0	9	9
53	R:R:H177	R:R:Y400	13.07	No	Yes	0	9	8
54	R:R:N179	R:R:W241	15.82	No	Yes	2	8	9
55	R:R:F264	R:R:N179	4.83	Yes	No	0	6	8
56	R:R:N179	R:R:W272	3.39	No	Yes	2	8	9
57	R:R:F184	R:R:L180	6.09	Yes	No	0	8	9
58	R:R:L180	R:R:L242	5.54	No	No	0	9	9
59	R:R:F181	R:R:V396	2.62	Yes	Yes	1	8	9
60	R:R:F181	R:R:Y400	3.09	Yes	Yes	1	8	8
61	R:R:C401	R:R:F181	2.79	Yes	Yes	1	9	8
62	R:R:N238	R:R:S183	5.96	No	No	0	9	9
63	R:R:S183	R:R:W241	2.47	No	Yes	2	9	9
64	R:R:S183	R:R:W272	2.47	No	Yes	2	9	9
65	R:R:F184	R:R:N238	21.75	Yes	No	0	8	9
66	R:R:F184	R:R:Q392	10.54	Yes	No	0	8	9
67	R:R:F184	R:R:G393	4.52	Yes	No	1	8	9
68	R:R:F184	R:R:V396	5.24	Yes	Yes	1	8	9
69	R:R:F230	R:R:L186	10.96	No	No	0	4	7
70	R:R:I235	R:R:K187	5.82	No	No	0	5	8
71	R:R:F230	R:R:S190	2.64	No	No	0	4	5
72	R:R:M231	R:R:S190	7.67	Yes	No	0	6	5
73	R:R:D195	R:R:V191	2.92	Yes	Yes	0	7	7
74	R:R:M231	R:R:V191	3.04	Yes	Yes	0	6	7
75	R:R:N298	R:R:V191	2.96	No	Yes	0	6	7
76	R:R:D195	R:R:I194	2.8	Yes	No	0	7	6
77	R:R:I194	R:R:M231	2.92	No	Yes	0	6	6
78	R:R:L198	R:R:Y202	3.52	No	No	0	6	1
79	R:R:C224	R:R:C294	5.46	No	No	0	9	9
80	R:R:C287	R:R:R225	8.36	No	No	0	3	8
81	R:R:Q293	R:R:R225	19.86	No	No	0	4	8
82	R:R:M231	R:R:T296	4.52	Yes	No	0	6	5
83	R:R:K286	R:R:Q232	5.42	No	No	0	8	7
84	R:R:Q232	R:R:W304	4.38	No	Yes	0	7	6
85	R:R:G234	R:R:Y233	2.9	No	Yes	0	5	9
86	R:R:A237	R:R:Y233	2.67	No	Yes	2	7	9
87	R:R:W272	R:R:Y233	6.75	Yes	Yes	2	9	9
88	R:R:P275	R:R:Y233	9.74	Yes	Yes	2	9	9
89	R:R:V279	R:R:Y233	3.79	Yes	Yes	2	6	9
90	R:R:P275	R:R:V236	3.53	Yes	No	2	9	6
91	R:R:V236	R:R:V279	3.21	No	Yes	2	6	6
92	R:R:L307	R:R:V236	4.47	No	No	2	7	6
93	R:R:A237	R:R:W272	2.59	No	Yes	2	7	9
94	R:R:A237	R:R:P275	3.74	No	Yes	2	7	9
95	R:R:L242	R:R:N238	2.75	No	No	0	9	9
96	R:R:V311	R:R:Y239	5.05	No	No	0	8	8
97	R:R:C240	R:R:P275	3.77	No	Yes	0	6	9
98	R:R:V244	R:R:W241	7.36	No	Yes	0	8	9
99	R:R:G271	R:R:W241	8.44	No	Yes	0	9	9
100	R:R:W241	R:R:W272	17.81	Yes	Yes	2	9	9
101	R:R:L243	R:R:L247	5.54	Yes	No	0	8	7
102	R:R:A314	R:R:L243	3.15	No	Yes	0	8	8
103	R:R:I317	R:R:L243	2.85	No	Yes	0	6	8
104	R:R:L243	R:R:N318	5.49	Yes	Yes	0	8	9
105	R:R:V244	R:R:Y267	3.79	No	No	0	8	7
106	R:R:E245	R:R:L358	3.98	No	Yes	0	9	9
107	R:R:G246	R:R:L358	3.42	No	Yes	0	9	9
108	R:R:L252	R:R:Y248	5.86	No	Yes	0	8	8
109	R:R:Y248	R:R:Y267	11.91	Yes	No	0	8	7
110	R:R:L249	R:R:L253	4.15	No	No	0	9	8
111	R:R:I325	R:R:L249	4.28	No	No	0	9	9
112	R:R:H250	R:R:I321	9.28	No	No	0	7	8
113	R:R:H250	R:R:R324	3.39	No	No	0	7	8
114	R:R:L255	R:R:N251	2.75	No	No	0	5	7
115	R:R:L252	R:R:P259	3.28	No	No	0	8	6
116	R:R:L253	R:R:L328	4.15	No	No	0	8	8
117	R:R:L255	R:R:P259	4.93	No	No	0	5	6
118	R:R:E260	R:R:F263	3.5	No	No	0	6	5
119	R:R:F263	R:R:R261	9.62	No	No	0	5	5
120	R:R:F264	R:R:L268	7.31	Yes	No	0	6	5
121	R:R:L266	W:W:N15	2.75	No	No	0	3	0
122	R:R:A274	R:R:F278	4.16	No	Yes	0	4	5
123	R:R:M276	R:R:V280	10.65	No	Yes	0	3	2
124	R:R:F278	R:R:L277	2.44	Yes	No	0	5	4
125	R:R:L277	W:W:D11	5.43	No	No	0	4	0
126	R:R:F278	R:R:P310	14.45	Yes	No	3	5	9
127	R:R:F278	W:W:M10	4.98	Yes	Yes	3	5	0
128	R:R:L307	R:R:V279	4.47	No	Yes	2	7	6
129	R:R:P281	R:R:V280	3.53	No	Yes	0	4	2
130	R:R:V285	R:R:W282	3.68	No	Yes	0	5	9
131	R:R:I306	R:R:W282	8.22	Yes	Yes	3	8	9
132	R:R:W282	W:W:F5	8.02	Yes	No	3	9	0
133	R:R:W282	W:W:M10	4.65	Yes	Yes	3	9	0
134	R:R:K286	R:R:Q293	4.07	No	No	0	8	4
135	R:R:E290	R:R:V292	2.85	No	No	0	6	4
136	R:R:E290	R:R:Q293	2.55	No	No	0	6	4
137	R:R:W295	R:R:W304	4.69	No	Yes	0	9	6
138	R:R:F303	R:R:W305	9.02	No	No	0	4	7
139	R:R:L307	R:R:W304	7.97	No	Yes	0	7	6
140	R:R:R308	R:R:W304	3	No	Yes	0	6	6
141	R:R:I306	W:W:F5	6.28	Yes	No	3	8	0
142	R:R:I306	W:W:S6	3.1	Yes	No	0	8	0
143	R:R:I306	W:W:M10	2.92	Yes	Yes	3	8	0
144	R:R:R308	R:R:V311	14.38	No	No	0	6	8
145	R:R:F312	R:R:R308	13.9	No	No	0	5	6
146	R:R:F309	R:R:P310	2.89	No	No	0	4	9
147	R:R:F309	W:W:V9	3.93	No	No	0	4	0
148	R:R:P310	W:W:M10	3.35	No	Yes	3	9	0
149	R:R:F312	R:R:V363	7.87	No	No	0	5	6
150	R:R:F320	R:R:L316	2.44	No	No	0	5	3
151	R:R:I317	R:R:I321	2.94	No	No	0	6	8
152	R:R:I321	R:R:N318	4.25	No	Yes	0	8	9
153	R:R:L358	R:R:N318	2.75	Yes	Yes	0	9	9
154	R:R:F319	R:R:V323	5.24	No	No	0	7	5
155	R:R:F319	R:R:H361	9.05	No	No	0	7	8
156	R:R:F322	R:R:V326	5.24	No	No	0	9	7
157	R:R:F322	R:R:L352	2.44	No	No	0	9	8
158	R:R:F322	R:R:I355	5.02	No	No	0	9	8
159	R:R:Q327	R:R:R324	4.67	No	No	0	8	8
160	R:R:K332	R:R:L328	2.82	No	No	0	9	8
161	R:R:L329	R:R:T351	4.42	No	No	0	9	9
162	R:R:R334	R:R:V330	5.23	No	No	0	7	6
163	R:R:L333	R:R:Q337	2.66	No	No	0	7	7
164	R:R:K344	R:R:L333	5.64	No	No	0	6	7
165	R:R:K344	R:R:R334	3.71	No	No	0	6	7
166	R:R:R346	R:R:Y343	4.12	No	No	0	8	7
167	R:R:F345	R:R:K344	3.72	No	No	0	7	6
168	R:R:K349	R:R:L352	4.23	No	No	0	9	8
169	R:R:L354	R:R:L399	2.77	No	Yes	0	9	8
170	R:R:I355	R:R:L358	2.85	No	Yes	0	8	9
171	R:R:L357	R:R:L358	5.54	No	Yes	0	9	9
172	R:R:L357	R:R:V396	7.45	No	Yes	1	9	9
173	R:R:L357	R:R:Y400	10.55	No	Yes	1	9	8
174	R:R:F367	R:R:V363	2.62	No	No	0	5	6
175	R:R:F365	R:R:V364	3.93	No	No	0	7	6
176	R:R:F365	R:R:K381	2.48	No	No	0	7	7
177	R:R:D385	R:R:F365	5.97	No	No	0	7	7
178	R:R:R378	R:R:V368	7.85	No	No	0	4	5
179	R:R:Q374	R:R:R378	3.5	No	No	0	4	4
180	R:R:S379	R:R:T376	3.2	No	No	0	3	2
181	R:R:L382	R:R:R378	15.79	No	No	0	5	4
182	R:R:D385	R:R:L382	5.43	No	No	0	7	5
183	R:R:F383	R:R:F384	8.57	Yes	No	0	5	4
184	R:R:F383	R:R:F387	5.36	Yes	Yes	4	5	5
185	R:R:F384	R:R:L388	2.44	No	No	0	4	6
186	R:R:F387	R:R:L388	3.65	Yes	No	0	5	6
187	R:R:F387	R:R:F391	7.5	Yes	Yes	0	5	7
188	R:R:F391	R:R:S390	3.96	Yes	No	0	7	9
189	R:R:F391	R:R:L394	2.44	Yes	No	0	7	5
190	R:R:L394	R:R:V398	2.98	No	No	0	5	6
191	R:R:L395	R:R:L399	6.92	No	Yes	0	6	8
192	R:R:V396	R:R:Y400	2.52	Yes	Yes	1	9	8
193	R:R:F402	R:R:V398	3.93	No	No	0	9	6
194	R:R:L403	R:R:V398	2.98	No	No	0	5	6
195	R:R:C401	R:R:F402	2.79	Yes	No	0	9	9
196	R:R:E406	R:R:N404	14.46	Yes	No	5	9	9
197	R:R:N404	R:R:V407	10.35	No	No	5	9	9
198	R:R:K405	R:R:Q408	5.42	No	No	0	6	7
199	R:R:E406	R:R:V407	5.7	Yes	No	5	9	9
200	R:R:E410	R:R:R413	4.65	No	No	0	8	7
201	R:R:H416	R:R:R412	3.39	No	No	0	3	5
202	R:R:R414	R:R:R417	13.86	No	No	0	5	7
203	R:R:H416	R:R:W415	6.35	No	No	0	3	5
204	R:R:R419	R:R:W415	6	No	No	0	5	5
205	R:R:R419	R:R:W418	13	No	No	0	5	3
206	R:R:G421	R:R:L420	3.42	No	No	0	4	4
207	R:R:K422	R:R:L420	4.23	No	No	0	5	4
208	W:W:P3	W:W:S6	5.34	No	No	0	0	0
209	W:W:N7	W:W:P3	14.66	No	No	0	0	0
210	W:W:F5	W:W:P4	5.78	No	No	0	0	0
211	R:R:L198	R:R:R199	2.43	No	No	0	6	4
212	R:R:I315	R:R:Y239	2.42	No	No	0	7	8
213	R:R:L399	R:R:Y400	2.34	Yes	Yes	0	8	8
214	R:R:F319	R:R:F320	2.14	No	No	0	7	5
215	R:R:G164	R:R:G165	2.11	No	No	0	3	3
216	R:R:R201	R:R:Y202	2.06	No	No	0	4	1
217	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
218	W:W:P1	W:W:P2	1.95	No	No	0	0	0
219	W:W:P2	W:W:P3	1.95	No	No	0	0	0
220	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
221	R:R:G148	R:R:V147	1.84	No	No	0	7	5
222	R:R:G223	R:R:V226	1.84	No	No	0	3	4
223	R:R:A155	R:R:A397	1.79	No	No	0	6	8
224	R:R:A159	R:R:A397	1.79	No	No	0	9	8
225	R:R:G154	R:R:L153	1.71	No	Yes	0	4	6
226	R:R:G164	R:R:L163	1.71	No	Yes	0	3	8
227	R:R:G164	R:R:L169	1.71	No	No	0	3	9
228	R:R:G165	R:R:L166	1.71	No	No	0	3	7
229	R:R:G223	R:R:L197	1.71	No	No	0	3	4
230	R:R:G269	R:R:L268	1.71	No	No	0	4	5
231	R:R:A227	R:R:V193	1.7	No	No	0	6	5
232	R:R:A283	R:R:V229	1.7	No	No	0	5	6
233	R:R:G359	R:R:N318	1.7	No	Yes	0	9	9
234	R:R:D195	R:R:G196	1.68	Yes	No	0	7	3
235	R:R:A228	R:R:T296	1.68	No	No	0	5	5
236	R:R:L258	R:R:P259	1.64	No	No	0	6	6
237	R:R:L399	R:R:P356	1.64	Yes	No	0	8	9
238	R:R:S189	R:R:V193	1.62	No	No	0	4	5
239	R:R:A227	R:R:I194	1.62	No	No	0	6	6
240	R:R:V221	R:R:V292	1.6	No	No	0	4	4
241	R:R:V279	R:R:V280	1.6	Yes	Yes	0	6	2
242	R:R:V280	R:R:V284	1.6	Yes	No	0	2	4
243	R:R:V326	R:R:V330	1.6	No	No	0	7	6
244	R:R:V363	R:R:V364	1.6	No	No	0	6	6
245	R:R:A178	R:R:L160	1.58	No	No	0	7	6
246	R:R:A178	R:R:L163	1.58	No	Yes	0	7	8
247	R:R:A274	W:W:L13	1.58	No	No	0	4	0
248	R:R:C287	R:R:N291	1.57	No	No	0	3	6
249	R:R:I162	R:R:V407	1.54	No	No	0	8	9
250	R:R:I270	R:R:V244	1.54	No	No	0	7	8
251	R:R:G196	R:R:R199	1.5	No	No	0	3	4
252	R:R:L197	R:R:V193	1.49	No	No	0	4	5
253	R:R:L258	R:R:T257	1.47	No	No	0	6	7
254	R:R:I325	R:R:I355	1.47	No	No	0	9	8
255	R:R:L352	R:R:T351	1.47	No	No	0	8	9
256	R:R:K136	R:R:M137	1.44	No	No	0	2	4
257	R:R:E406	R:R:S409	1.44	Yes	No	0	9	4
258	R:R:Q327	R:R:V323	1.43	No	No	0	8	5
259	R:R:E362	R:R:V360	1.43	No	No	0	8	6
260	R:R:Q392	R:R:V360	1.43	No	No	0	9	6
261	R:R:L153	R:R:L192	1.38	Yes	No	0	6	7
262	R:R:L333	R:R:L347	1.38	No	No	0	7	9
263	R:R:L377	R:R:Q374	1.33	No	No	0	3	4
264	R:R:A182	R:R:W272	1.3	No	Yes	0	4	9
265	R:R:F391	R:R:L151	1.22	Yes	No	0	7	5
266	R:R:F263	R:R:L266	1.22	No	No	0	5	3
267	R:R:E290	R:R:F289	1.17	No	No	0	6	3
268	R:R:W282	W:W:L8	1.14	Yes	No	0	9	0
269	R:R:H340	R:R:Y343	1.09	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F141	6.3925	4	0	6
2	R:R:Y145	7.702	5	0	7
3	R:R:Y149	9.4	4	0	8
4	R:R:L153	2.6475	4	0	6
5	R:R:L156	4.7125	4	1	8
6	R:R:L163	2.604	5	1	8
7	R:R:I176	4.68	4	0	9
8	R:R:F181	3.52429	7	1	8
9	R:R:F184	9.03833	6	1	8
10	R:R:V191	7.2775	4	0	7
11	R:R:D195	4.435	4	0	7
12	R:R:M231	4.5375	4	0	6
13	R:R:Y233	5.17	5	2	9
14	R:R:W241	9.43333	6	2	9
15	R:R:L243	4.2575	4	0	8
16	R:R:Y248	8.7625	4	0	8
17	R:R:F264	4.7025	4	0	6
18	R:R:W272	5.71833	6	2	9
19	R:R:P275	4.11333	6	2	9
20	R:R:F278	6.5075	4	3	5
21	R:R:V279	3.2675	4	2	6
22	R:R:V280	4.345	4	0	2
23	R:R:W282	5.142	5	3	9
24	R:R:W304	5.01	4	0	6
25	R:R:I306	5.13	4	3	8
26	R:R:N318	3.5475	4	0	9
27	R:R:L358	3.708	5	0	9
28	R:R:F383	7.675	4	4	5
29	R:R:F387	5.06	4	4	5
30	R:R:F391	4.83	5	0	7
31	R:R:V396	4.4575	4	1	9
32	R:R:L399	3.4175	4	0	8
33	R:R:Y400	6.314	5	1	8
34	R:R:C401	3.126	5	1	9
35	R:R:E406	6.075	4	5	9
36	W:W:M10	3.975	4	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F141	R:R:F383	11.9102	11.79	Yes	Yes	0	6	5
2	R:R:F383	R:R:F387	15.2917	5.36	Yes	Yes	4	5	5
3	R:R:D195	R:R:Y145	26.4997	10.34	Yes	Yes	0	7	7
4	R:R:S390	R:R:Y145	32.602	2.54	No	Yes	0	9	7
5	R:R:F387	R:R:F391	23.2576	7.5	Yes	Yes	0	5	7
6	R:R:S390	R:R:Y149	23.1285	8.9	No	Yes	0	9	8
7	R:R:F391	R:R:L394	85.6066	2.44	Yes	No	0	7	5
8	R:R:L394	R:R:V398	87.2277	2.98	No	No	0	5	6
9	R:R:F402	R:R:V398	90.4388	3.93	No	No	0	9	6
10	R:R:C401	R:R:F402	93.6087	2.79	Yes	No	0	9	9
11	R:R:C401	R:R:F181	100	2.79	Yes	Yes	1	9	8
12	R:R:F181	R:R:L156	50.0103	4.87	Yes	Yes	1	8	8
13	R:R:L156	R:R:V185	10.8673	4.47	Yes	No	0	8	8
14	R:R:F184	R:R:L156	49.1533	6.09	Yes	Yes	1	8	8
15	R:R:F181	R:R:V396	60.1136	2.62	Yes	Yes	1	8	9
16	R:R:F184	R:R:V396	50.031	5.24	Yes	Yes	1	8	9
17	R:R:C401	R:R:I162	14.3314	3.27	Yes	No	0	9	8
18	R:R:G164	R:R:L163	23.7894	1.71	No	Yes	0	3	8
19	R:R:G164	R:R:G165	17.3619	2.11	No	No	0	3	3
20	R:R:G165	R:R:L166	15.1988	1.71	No	No	0	3	7
21	R:R:I162	R:R:V407	10.3717	1.54	No	No	0	8	9
22	R:R:F181	R:R:Y400	28.7352	3.09	Yes	Yes	1	8	8
23	R:R:H177	R:R:Y400	13.2163	13.07	No	Yes	0	9	8
24	R:R:E245	R:R:H177	17.047	13.54	No	No	0	9	9
25	R:R:E245	R:R:I176	38.6474	5.47	No	Yes	0	9	9
26	R:R:I176	R:R:Y248	13.1079	6.04	Yes	Yes	0	9	8
27	R:R:F184	R:R:N238	93.3092	21.75	Yes	No	0	8	9
28	R:R:N238	R:R:S183	92.9427	5.96	No	No	0	9	9
29	R:R:I176	R:R:W241	32.731	4.7	Yes	Yes	0	9	9
30	R:R:S183	R:R:W272	86.4584	2.47	No	Yes	2	9	9
31	R:R:M231	R:R:V191	12.3593	3.04	Yes	Yes	0	6	7
32	R:R:D195	R:R:I194	14.7909	2.8	Yes	No	0	7	6
33	R:R:D195	R:R:G196	10.5266	1.68	Yes	No	0	7	3
34	R:R:W272	R:R:Y233	81.0015	6.75	Yes	Yes	2	9	9
35	R:R:V279	R:R:Y233	46.1229	3.79	Yes	Yes	2	6	9
36	R:R:L307	R:R:V279	38.3789	4.47	No	Yes	2	7	6
37	R:R:L307	R:R:W304	41.1513	7.97	No	Yes	0	7	6
38	R:R:Q232	R:R:W304	15.6479	4.38	No	Yes	0	7	6
39	R:R:K286	R:R:Q232	14.1456	5.42	No	No	0	8	7
40	R:R:K286	R:R:Q293	12.6329	4.07	No	No	0	8	4
41	R:R:A237	R:R:W272	34.7651	2.59	No	Yes	2	7	9
42	R:R:P275	R:R:Y233	34.3882	9.74	Yes	Yes	2	9	9
43	R:R:A237	R:R:P275	33.7584	3.74	No	Yes	2	7	9
44	R:R:R308	R:R:W304	24.5121	3	No	Yes	0	6	6
45	R:R:L357	R:R:V396	20.5421	7.45	No	Yes	1	9	9
46	R:R:L357	R:R:L358	37.4393	5.54	No	Yes	0	9	9
47	R:R:L358	R:R:N318	27.5013	2.75	Yes	Yes	0	9	9
48	R:R:L357	R:R:Y400	17.6149	10.55	No	Yes	1	9	8
49	R:R:I321	R:R:N318	17.429	4.25	No	Yes	0	8	9
50	R:R:I355	R:R:L358	32.1631	2.85	No	Yes	0	8	9
51	R:R:H250	R:R:I321	14.1611	9.28	No	No	0	7	8
52	R:R:H250	R:R:R324	12.4264	3.39	No	No	0	7	8
53	R:R:A274	R:R:P275	61.8482	1.87	No	Yes	0	4	9
54	R:R:A274	R:R:F278	56.4171	4.16	No	Yes	0	4	5
55	R:R:F278	W:W:M10	39.8193	4.98	Yes	Yes	3	5	0
56	R:R:W282	W:W:M10	14.3211	4.65	Yes	Yes	3	9	0
57	R:R:I306	W:W:M10	22.9169	2.92	Yes	Yes	3	8	0
58	R:R:I306	W:W:S6	14.476	3.1	Yes	No	0	8	0
59	R:R:F312	R:R:R308	18.6061	13.9	No	No	0	5	6
60	R:R:F312	R:R:V363	17.1038	7.87	No	No	0	5	6
61	R:R:Q327	R:R:R324	10.6815	4.67	No	No	0	8	8
62	R:R:F322	R:R:I355	22.4109	5.02	No	No	0	9	8
63	R:R:F322	R:R:V326	14.0062	5.24	No	No	0	9	7
64	R:R:V326	R:R:V330	12.2819	1.6	No	No	0	7	6
65	R:R:R334	R:R:V330	10.5472	5.23	No	No	0	7	6
66	R:R:V363	R:R:V364	14.0681	1.6	No	No	0	6	6
67	R:R:F365	R:R:V364	12.5348	3.93	No	No	0	7	6
68	W:W:P3	W:W:S6	11.6004	5.34	No	No	0	0	0
69	R:R:A227	R:R:I194	12.602	1.62	No	No	0	6	6
70	R:R:A227	R:R:V193	10.5266	1.7	No	No	0	6	5
71	R:R:F391	R:R:S390	57.0573	3.96	Yes	No	0	7	9
72	R:R:V191	R:R:Y149	15.8183	20.19	Yes	Yes	0	7	8
73	R:R:F181	R:R:L163	22.4884	2.44	Yes	Yes	1	8	8
74	R:R:E245	R:R:L358	23.3505	3.98	No	Yes	0	9	9
75	R:R:W241	R:R:W272	29.8141	17.81	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L266	W:W:N15	2.75	0	No	No	3	0	1	0
R:R:A274	R:R:F278	4.16	0	No	Yes	4	5	1	1
R:R:F278	R:R:L277	2.44	3	Yes	No	5	4	1	1
R:R:L277	W:W:D11	5.43	0	No	No	4	0	1	0
R:R:F278	R:R:P310	14.45	3	Yes	No	5	9	1	1
R:R:F278	W:W:M10	4.98	3	Yes	Yes	5	0	1	0
R:R:V285	R:R:W282	3.68	0	No	Yes	5	9	2	1
R:R:I306	R:R:W282	8.22	3	Yes	Yes	8	9	1	1
R:R:W282	W:W:F5	8.02	3	Yes	No	9	0	1	0
R:R:W282	W:W:M10	4.65	3	Yes	Yes	9	0	1	0
R:R:I306	W:W:F5	6.28	3	Yes	No	8	0	1	0
R:R:I306	W:W:S6	3.1	3	Yes	No	8	0	1	0
R:R:I306	W:W:M10	2.92	3	Yes	Yes	8	0	1	0
R:R:F309	R:R:P310	2.89	0	No	No	4	9	1	1
R:R:F309	W:W:V9	3.93	0	No	No	4	0	1	0
R:R:P310	W:W:M10	3.35	3	No	Yes	9	0	1	0
R:R:A274	R:R:P275	1.87	0	No	Yes	4	9	1	2
R:R:A274	W:W:L13	1.58	0	No	No	4	0	1	0
R:R:F263	R:R:L266	1.22	0	No	No	5	3	2	1
R:R:W282	W:W:L8	1.14	3	Yes	No	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WG8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	248
Number of Links	269
Number of Hubs	36
Number of Links mediated by Hubs	132
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	44150
Length Of Smallest Path	3
Average Path Length	14.2285
Length of Longest Path	34
Minimum Path Strength	1.43
Average Path Strength	5.25889
Maximum Path Strength	16.145
Minimum Path Correlation	0.7
Average Path Correlation	0.949504
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.7984
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8481
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • ciliary basal body • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • peptide hormone binding • hormone binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • circulatory system process • regulation of blood pressure • blood circulation • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • cellular response to nutrient levels • response to nutrient levels • response to starvation • cellular response to starvation • cell surface receptor signaling pathway • response to nutrient • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>8WG8_nogp_Chain_R A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A T L P E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W R L G K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	doi.org/10.1038/nature12393
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	doi.org/10.1038/nature17414
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	doi.org/10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	doi.org/10.1038/nature22363
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	NNC1702	-	-	3	2018-01-17	doi.org/10.1038/nature25153
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-		3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-		2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	9E2A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	3.3	2025-10-29	To be published
	9E2A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		3.3	2025-10-29	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.