psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A135	R:R:Y138	4	No	No	0	3	5
2	R:R:M137	R:R:Y138	3.59	No	No	0	4	5
3	R:R:F141	R:R:M137	3.73	Yes	No	0	6	4
4	R:R:F141	R:R:S140	3.96	Yes	No	0	6	4
5	R:R:F141	R:R:F383	11.79	Yes	Yes	0	6	5
6	R:R:F141	R:R:L386	6.09	Yes	No	0	6	7
7	R:R:Q142	R:R:Y145	13.53	No	Yes	0	5	7
8	R:R:F383	R:R:M144	4.98	Yes	No	4	5	6
9	R:R:F387	R:R:M144	3.73	Yes	No	4	5	6
10	R:R:T146	R:R:Y145	6.24	No	Yes	0	7	7
11	R:R:D195	R:R:Y145	10.34	Yes	Yes	0	7	7
12	R:R:L386	R:R:Y145	5.86	No	Yes	0	7	7
13	R:R:S390	R:R:Y145	2.54	No	Yes	0	9	7
14	R:R:F391	R:R:G148	9.03	Yes	No	0	7	7
15	R:R:S152	R:R:Y149	2.54	No	Yes	0	9	8
16	R:R:K187	R:R:Y149	5.97	No	Yes	0	8	8
17	R:R:V191	R:R:Y149	20.19	Yes	Yes	0	7	8
18	R:R:S390	R:R:Y149	8.9	No	Yes	0	9	8
19	R:R:L153	R:R:L157	2.77	Yes	No	0	6	3
20	R:R:A188	R:R:L153	4.73	No	Yes	0	8	6
21	R:R:F181	R:R:L156	4.87	Yes	Yes	1	8	8
22	R:R:F184	R:R:L156	6.09	Yes	Yes	1	8	8
23	R:R:L156	R:R:V185	4.47	Yes	No	0	8	8
24	R:R:G393	R:R:L156	3.42	No	Yes	1	9	8
25	R:R:L157	R:R:V185	2.98	No	No	0	3	8
26	R:R:F402	R:R:L158	6.09	No	No	0	9	5
27	R:R:A159	R:R:F181	2.77	No	Yes	1	9	8
28	R:R:A159	R:R:C401	3.61	No	Yes	1	9	9
29	R:R:F181	R:R:L160	6.09	Yes	No	0	8	6
30	R:R:C401	R:R:I162	3.27	Yes	No	0	9	8
31	R:R:I162	R:R:L411	2.85	No	No	0	8	5
32	R:R:L163	R:R:N174	4.12	Yes	No	1	8	9
33	R:R:F181	R:R:L163	2.44	Yes	Yes	1	8	8
34	R:R:C401	R:R:L163	3.17	Yes	Yes	1	9	8
35	R:R:E410	R:R:L166	6.63	No	No	0	8	7
36	R:R:L166	R:R:R414	7.29	No	No	0	7	5
37	R:R:E410	R:R:S167	4.31	No	No	0	8	8
38	R:R:R414	R:R:S167	2.64	No	No	0	5	8
39	R:R:E406	R:R:K168	2.7	Yes	No	0	9	8
40	R:R:H170	R:R:L169	9	No	No	0	7	9
41	R:R:C171	R:R:R173	5.57	No	No	1	7	9
42	R:R:C171	R:R:N174	3.15	No	No	1	7	9
43	R:R:T172	R:R:Y248	11.24	No	Yes	0	7	8
44	R:R:S262	R:R:T172	6.4	No	No	0	5	7
45	R:R:N174	R:R:R173	6.03	No	No	1	9	9
46	R:R:H177	R:R:R173	6.77	No	No	0	9	9
47	R:R:A175	R:R:F264	4.16	No	Yes	0	6	6
48	R:R:I176	R:R:W241	4.7	Yes	Yes	0	9	9
49	R:R:E245	R:R:I176	5.47	No	Yes	0	9	9
50	R:R:I176	R:R:Y248	6.04	Yes	Yes	0	9	8
51	R:R:F264	R:R:I176	2.51	Yes	Yes	0	6	9
52	R:R:E245	R:R:H177	13.54	No	No	0	9	9
53	R:R:H177	R:R:Y400	13.07	No	Yes	0	9	8
54	R:R:N179	R:R:W241	15.82	No	Yes	2	8	9
55	R:R:F264	R:R:N179	4.83	Yes	No	0	6	8
56	R:R:N179	R:R:W272	3.39	No	Yes	2	8	9
57	R:R:F184	R:R:L180	6.09	Yes	No	0	8	9
58	R:R:L180	R:R:L242	5.54	No	No	0	9	9
59	R:R:F181	R:R:V396	2.62	Yes	Yes	1	8	9
60	R:R:F181	R:R:Y400	3.09	Yes	Yes	1	8	8
61	R:R:C401	R:R:F181	2.79	Yes	Yes	1	9	8
62	R:R:N238	R:R:S183	5.96	No	No	0	9	9
63	R:R:S183	R:R:W241	2.47	No	Yes	2	9	9
64	R:R:S183	R:R:W272	2.47	No	Yes	2	9	9
65	R:R:F184	R:R:N238	21.75	Yes	No	0	8	9
66	R:R:F184	R:R:Q392	10.54	Yes	No	0	8	9
67	R:R:F184	R:R:G393	4.52	Yes	No	1	8	9
68	R:R:F184	R:R:V396	5.24	Yes	Yes	1	8	9
69	R:R:F230	R:R:L186	10.96	No	No	0	4	7
70	R:R:I235	R:R:K187	5.82	No	No	0	5	8
71	R:R:F230	R:R:S190	2.64	No	No	0	4	5
72	R:R:M231	R:R:S190	7.67	Yes	No	0	6	5
73	R:R:D195	R:R:V191	2.92	Yes	Yes	0	7	7
74	R:R:M231	R:R:V191	3.04	Yes	Yes	0	6	7
75	R:R:N298	R:R:V191	2.96	No	Yes	0	6	7
76	R:R:D195	R:R:I194	2.8	Yes	No	0	7	6
77	R:R:I194	R:R:M231	2.92	No	Yes	0	6	6
78	R:R:L198	R:R:Y202	3.52	No	No	0	6	1
79	R:R:C224	R:R:C294	5.46	No	No	0	9	9
80	R:R:C287	R:R:R225	8.36	No	No	0	3	8
81	R:R:Q293	R:R:R225	19.86	No	No	0	4	8
82	R:R:M231	R:R:T296	4.52	Yes	No	0	6	5
83	R:R:K286	R:R:Q232	5.42	No	No	0	8	7
84	R:R:Q232	R:R:W304	4.38	No	Yes	0	7	6
85	R:R:G234	R:R:Y233	2.9	No	Yes	0	5	9
86	R:R:A237	R:R:Y233	2.67	No	Yes	2	7	9
87	R:R:W272	R:R:Y233	6.75	Yes	Yes	2	9	9
88	R:R:P275	R:R:Y233	9.74	Yes	Yes	2	9	9
89	R:R:V279	R:R:Y233	3.79	Yes	Yes	2	6	9
90	R:R:P275	R:R:V236	3.53	Yes	No	2	9	6
91	R:R:V236	R:R:V279	3.21	No	Yes	2	6	6
92	R:R:L307	R:R:V236	4.47	No	No	2	7	6
93	R:R:A237	R:R:W272	2.59	No	Yes	2	7	9
94	R:R:A237	R:R:P275	3.74	No	Yes	2	7	9
95	R:R:L242	R:R:N238	2.75	No	No	0	9	9
96	R:R:V311	R:R:Y239	5.05	No	No	0	8	8
97	R:R:C240	R:R:P275	3.77	No	Yes	0	6	9
98	R:R:V244	R:R:W241	7.36	No	Yes	0	8	9
99	R:R:G271	R:R:W241	8.44	No	Yes	0	9	9
100	R:R:W241	R:R:W272	17.81	Yes	Yes	2	9	9
101	R:R:L243	R:R:L247	5.54	Yes	No	0	8	7
102	R:R:A314	R:R:L243	3.15	No	Yes	0	8	8
103	R:R:I317	R:R:L243	2.85	No	Yes	0	6	8
104	R:R:L243	R:R:N318	5.49	Yes	Yes	0	8	9
105	R:R:V244	R:R:Y267	3.79	No	No	0	8	7
106	R:R:E245	R:R:L358	3.98	No	Yes	0	9	9
107	R:R:G246	R:R:L358	3.42	No	Yes	0	9	9
108	R:R:L252	R:R:Y248	5.86	No	Yes	0	8	8
109	R:R:Y248	R:R:Y267	11.91	Yes	No	0	8	7
110	R:R:L249	R:R:L253	4.15	No	No	0	9	8
111	R:R:I325	R:R:L249	4.28	No	No	0	9	9
112	R:R:H250	R:R:I321	9.28	No	No	0	7	8
113	R:R:H250	R:R:R324	3.39	No	No	0	7	8
114	R:R:L255	R:R:N251	2.75	No	No	0	5	7
115	R:R:L252	R:R:P259	3.28	No	No	0	8	6
116	R:R:L253	R:R:L328	4.15	No	No	0	8	8
117	R:R:L255	R:R:P259	4.93	No	No	0	5	6
118	R:R:E260	R:R:F263	3.5	No	No	0	6	5
119	R:R:F263	R:R:R261	9.62	No	No	0	5	5
120	R:R:F264	R:R:L268	7.31	Yes	No	0	6	5
121	R:R:L266	W:W:N15	2.75	No	No	0	3	0
122	R:R:A274	R:R:F278	4.16	No	Yes	0	4	5
123	R:R:M276	R:R:V280	10.65	No	Yes	0	3	2
124	R:R:F278	R:R:L277	2.44	Yes	No	0	5	4
125	R:R:L277	W:W:D11	5.43	No	No	0	4	0
126	R:R:F278	R:R:P310	14.45	Yes	No	3	5	9
127	R:R:F278	W:W:M10	4.98	Yes	Yes	3	5	0
128	R:R:L307	R:R:V279	4.47	No	Yes	2	7	6
129	R:R:P281	R:R:V280	3.53	No	Yes	0	4	2
130	R:R:V285	R:R:W282	3.68	No	Yes	0	5	9
131	R:R:I306	R:R:W282	8.22	Yes	Yes	3	8	9
132	R:R:W282	W:W:F5	8.02	Yes	No	3	9	0
133	R:R:W282	W:W:M10	4.65	Yes	Yes	3	9	0
134	R:R:K286	R:R:Q293	4.07	No	No	0	8	4
135	R:R:E290	R:R:V292	2.85	No	No	0	6	4
136	R:R:E290	R:R:Q293	2.55	No	No	0	6	4
137	R:R:W295	R:R:W304	4.69	No	Yes	0	9	6
138	R:R:F303	R:R:W305	9.02	No	No	0	4	7
139	R:R:L307	R:R:W304	7.97	No	Yes	0	7	6
140	R:R:R308	R:R:W304	3	No	Yes	0	6	6
141	R:R:I306	W:W:F5	6.28	Yes	No	3	8	0
142	R:R:I306	W:W:S6	3.1	Yes	No	0	8	0
143	R:R:I306	W:W:M10	2.92	Yes	Yes	3	8	0
144	R:R:R308	R:R:V311	14.38	No	No	0	6	8
145	R:R:F312	R:R:R308	13.9	No	No	0	5	6
146	R:R:F309	R:R:P310	2.89	No	No	0	4	9
147	R:R:F309	W:W:V9	3.93	No	No	0	4	0
148	R:R:P310	W:W:M10	3.35	No	Yes	3	9	0
149	R:R:F312	R:R:V363	7.87	No	No	0	5	6
150	R:R:F320	R:R:L316	2.44	No	No	0	5	3
151	R:R:I317	R:R:I321	2.94	No	No	0	6	8
152	R:R:I321	R:R:N318	4.25	No	Yes	0	8	9
153	R:R:L358	R:R:N318	2.75	Yes	Yes	0	9	9
154	R:R:F319	R:R:V323	5.24	No	No	0	7	5
155	R:R:F319	R:R:H361	9.05	No	No	0	7	8
156	R:R:F322	R:R:V326	5.24	No	No	0	9	7
157	R:R:F322	R:R:L352	2.44	No	No	0	9	8
158	R:R:F322	R:R:I355	5.02	No	No	0	9	8
159	R:R:Q327	R:R:R324	4.67	No	No	0	8	8
160	R:R:K332	R:R:L328	2.82	No	No	0	9	8
161	R:R:L329	R:R:T351	4.42	No	No	0	9	9
162	R:R:R334	R:R:V330	5.23	No	No	0	7	6
163	R:R:L333	R:R:Q337	2.66	No	No	0	7	7
164	R:R:K344	R:R:L333	5.64	No	No	0	6	7
165	R:R:K344	R:R:R334	3.71	No	No	0	6	7
166	R:R:R346	R:R:Y343	4.12	No	No	0	8	7
167	R:R:F345	R:R:K344	3.72	No	No	0	7	6
168	R:R:K349	R:R:L352	4.23	No	No	0	9	8
169	R:R:L354	R:R:L399	2.77	No	Yes	0	9	8
170	R:R:I355	R:R:L358	2.85	No	Yes	0	8	9
171	R:R:L357	R:R:L358	5.54	No	Yes	0	9	9
172	R:R:L357	R:R:V396	7.45	No	Yes	1	9	9
173	R:R:L357	R:R:Y400	10.55	No	Yes	1	9	8
174	R:R:F367	R:R:V363	2.62	No	No	0	5	6
175	R:R:F365	R:R:V364	3.93	No	No	0	7	6
176	R:R:F365	R:R:K381	2.48	No	No	0	7	7
177	R:R:D385	R:R:F365	5.97	No	No	0	7	7
178	R:R:R378	R:R:V368	7.85	No	No	0	4	5
179	R:R:Q374	R:R:R378	3.5	No	No	0	4	4
180	R:R:S379	R:R:T376	3.2	No	No	0	3	2
181	R:R:L382	R:R:R378	15.79	No	No	0	5	4
182	R:R:D385	R:R:L382	5.43	No	No	0	7	5
183	R:R:F383	R:R:F384	8.57	Yes	No	0	5	4
184	R:R:F383	R:R:F387	5.36	Yes	Yes	4	5	5
185	R:R:F384	R:R:L388	2.44	No	No	0	4	6
186	R:R:F387	R:R:L388	3.65	Yes	No	0	5	6
187	R:R:F387	R:R:F391	7.5	Yes	Yes	0	5	7
188	R:R:F391	R:R:S390	3.96	Yes	No	0	7	9
189	R:R:F391	R:R:L394	2.44	Yes	No	0	7	5
190	R:R:L394	R:R:V398	2.98	No	No	0	5	6
191	R:R:L395	R:R:L399	6.92	No	Yes	0	6	8
192	R:R:V396	R:R:Y400	2.52	Yes	Yes	1	9	8
193	R:R:F402	R:R:V398	3.93	No	No	0	9	6
194	R:R:L403	R:R:V398	2.98	No	No	0	5	6
195	R:R:C401	R:R:F402	2.79	Yes	No	0	9	9
196	R:R:E406	R:R:N404	14.46	Yes	No	5	9	9
197	R:R:N404	R:R:V407	10.35	No	No	5	9	9
198	R:R:K405	R:R:Q408	5.42	No	No	0	6	7
199	R:R:E406	R:R:V407	5.7	Yes	No	5	9	9
200	R:R:E410	R:R:R413	4.65	No	No	0	8	7
201	R:R:H416	R:R:R412	3.39	No	No	0	3	5
202	R:R:R414	R:R:R417	13.86	No	No	0	5	7
203	R:R:H416	R:R:W415	6.35	No	No	0	3	5
204	R:R:R419	R:R:W415	6	No	No	0	5	5
205	R:R:R419	R:R:W418	13	No	No	0	5	3
206	R:R:G421	R:R:L420	3.42	No	No	0	4	4
207	R:R:K422	R:R:L420	4.23	No	No	0	5	4
208	W:W:P3	W:W:S6	5.34	No	No	0	0	0
209	W:W:N7	W:W:P3	14.66	No	No	0	0	0
210	W:W:F5	W:W:P4	5.78	No	No	0	0	0
211	R:R:L198	R:R:R199	2.43	No	No	0	6	4
212	R:R:I315	R:R:Y239	2.42	No	No	0	7	8
213	R:R:L399	R:R:Y400	2.34	Yes	Yes	0	8	8
214	R:R:F319	R:R:F320	2.14	No	No	0	7	5
215	R:R:G164	R:R:G165	2.11	No	No	0	3	3
216	R:R:R201	R:R:Y202	2.06	No	No	0	4	1
217	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
218	W:W:P1	W:W:P2	1.95	No	No	0	0	0
219	W:W:P2	W:W:P3	1.95	No	No	0	0	0
220	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
221	R:R:G148	R:R:V147	1.84	No	No	0	7	5
222	R:R:G223	R:R:V226	1.84	No	No	0	3	4
223	R:R:A155	R:R:A397	1.79	No	No	0	6	8
224	R:R:A159	R:R:A397	1.79	No	No	0	9	8
225	R:R:G154	R:R:L153	1.71	No	Yes	0	4	6
226	R:R:G164	R:R:L163	1.71	No	Yes	0	3	8
227	R:R:G164	R:R:L169	1.71	No	No	0	3	9
228	R:R:G165	R:R:L166	1.71	No	No	0	3	7
229	R:R:G223	R:R:L197	1.71	No	No	0	3	4
230	R:R:G269	R:R:L268	1.71	No	No	0	4	5
231	R:R:A227	R:R:V193	1.7	No	No	0	6	5
232	R:R:A283	R:R:V229	1.7	No	No	0	5	6
233	R:R:G359	R:R:N318	1.7	No	Yes	0	9	9
234	R:R:D195	R:R:G196	1.68	Yes	No	0	7	3
235	R:R:A228	R:R:T296	1.68	No	No	0	5	5
236	R:R:L258	R:R:P259	1.64	No	No	0	6	6
237	R:R:L399	R:R:P356	1.64	Yes	No	0	8	9
238	R:R:S189	R:R:V193	1.62	No	No	0	4	5
239	R:R:A227	R:R:I194	1.62	No	No	0	6	6
240	R:R:V221	R:R:V292	1.6	No	No	0	4	4
241	R:R:V279	R:R:V280	1.6	Yes	Yes	0	6	2
242	R:R:V280	R:R:V284	1.6	Yes	No	0	2	4
243	R:R:V326	R:R:V330	1.6	No	No	0	7	6
244	R:R:V363	R:R:V364	1.6	No	No	0	6	6
245	R:R:A178	R:R:L160	1.58	No	No	0	7	6
246	R:R:A178	R:R:L163	1.58	No	Yes	0	7	8
247	R:R:A274	W:W:L13	1.58	No	No	0	4	0
248	R:R:C287	R:R:N291	1.57	No	No	0	3	6
249	R:R:I162	R:R:V407	1.54	No	No	0	8	9
250	R:R:I270	R:R:V244	1.54	No	No	0	7	8
251	R:R:G196	R:R:R199	1.5	No	No	0	3	4
252	R:R:L197	R:R:V193	1.49	No	No	0	4	5
253	R:R:L258	R:R:T257	1.47	No	No	0	6	7
254	R:R:I325	R:R:I355	1.47	No	No	0	9	8
255	R:R:L352	R:R:T351	1.47	No	No	0	8	9
256	R:R:K136	R:R:M137	1.44	No	No	0	2	4
257	R:R:E406	R:R:S409	1.44	Yes	No	0	9	4
258	R:R:Q327	R:R:V323	1.43	No	No	0	8	5
259	R:R:E362	R:R:V360	1.43	No	No	0	8	6
260	R:R:Q392	R:R:V360	1.43	No	No	0	9	6
261	R:R:L153	R:R:L192	1.38	Yes	No	0	6	7
262	R:R:L333	R:R:L347	1.38	No	No	0	7	9
263	R:R:L377	R:R:Q374	1.33	No	No	0	3	4
264	R:R:A182	R:R:W272	1.3	No	Yes	0	4	9
265	R:R:F391	R:R:L151	1.22	Yes	No	0	7	5
266	R:R:F263	R:R:L266	1.22	No	No	0	5	3
267	R:R:E290	R:R:F289	1.17	No	No	0	6	3
268	R:R:W282	W:W:L8	1.14	Yes	No	0	9	0
269	R:R:H340	R:R:Y343	1.09	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F141	6.3925	4	0	6
2	R:R:Y145	7.702	5	0	7
3	R:R:Y149	9.4	4	0	8
4	R:R:L153	2.6475	4	0	6
5	R:R:L156	4.7125	4	1	8
6	R:R:L163	2.604	5	1	8
7	R:R:I176	4.68	4	0	9
8	R:R:F181	3.52429	7	1	8
9	R:R:F184	9.03833	6	1	8
10	R:R:V191	7.2775	4	0	7
11	R:R:D195	4.435	4	0	7
12	R:R:M231	4.5375	4	0	6
13	R:R:Y233	5.17	5	2	9
14	R:R:W241	9.43333	6	2	9
15	R:R:L243	4.2575	4	0	8
16	R:R:Y248	8.7625	4	0	8
17	R:R:F264	4.7025	4	0	6
18	R:R:W272	5.71833	6	2	9
19	R:R:P275	4.11333	6	2	9
20	R:R:F278	6.5075	4	3	5
21	R:R:V279	3.2675	4	2	6
22	R:R:V280	4.345	4	0	2
23	R:R:W282	5.142	5	3	9
24	R:R:W304	5.01	4	0	6
25	R:R:I306	5.13	4	3	8
26	R:R:N318	3.5475	4	0	9
27	R:R:L358	3.708	5	0	9
28	R:R:F383	7.675	4	4	5
29	R:R:F387	5.06	4	4	5
30	R:R:F391	4.83	5	0	7
31	R:R:V396	4.4575	4	1	9
32	R:R:L399	3.4175	4	0	8
33	R:R:Y400	6.314	5	1	8
34	R:R:C401	3.126	5	1	9
35	R:R:E406	6.075	4	5	9
36	W:W:M10	3.975	4	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F141	R:R:F383	11.9102	11.79	Yes	Yes	0	6	5
2	R:R:F383	R:R:F387	15.2917	5.36	Yes	Yes	4	5	5
3	R:R:D195	R:R:Y145	26.4997	10.34	Yes	Yes	0	7	7
4	R:R:S390	R:R:Y145	32.602	2.54	No	Yes	0	9	7
5	R:R:F387	R:R:F391	23.2576	7.5	Yes	Yes	0	5	7
6	R:R:S390	R:R:Y149	23.1285	8.9	No	Yes	0	9	8
7	R:R:F391	R:R:L394	85.6066	2.44	Yes	No	0	7	5
8	R:R:L394	R:R:V398	87.2277	2.98	No	No	0	5	6
9	R:R:F402	R:R:V398	90.4388	3.93	No	No	0	9	6
10	R:R:C401	R:R:F402	93.6087	2.79	Yes	No	0	9	9
11	R:R:C401	R:R:F181	100	2.79	Yes	Yes	1	9	8
12	R:R:F181	R:R:L156	50.0103	4.87	Yes	Yes	1	8	8
13	R:R:L156	R:R:V185	10.8673	4.47	Yes	No	0	8	8
14	R:R:F184	R:R:L156	49.1533	6.09	Yes	Yes	1	8	8
15	R:R:F181	R:R:V396	60.1136	2.62	Yes	Yes	1	8	9
16	R:R:F184	R:R:V396	50.031	5.24	Yes	Yes	1	8	9
17	R:R:C401	R:R:I162	14.3314	3.27	Yes	No	0	9	8
18	R:R:G164	R:R:L163	23.7894	1.71	No	Yes	0	3	8
19	R:R:G164	R:R:G165	17.3619	2.11	No	No	0	3	3
20	R:R:G165	R:R:L166	15.1988	1.71	No	No	0	3	7
21	R:R:I162	R:R:V407	10.3717	1.54	No	No	0	8	9
22	R:R:F181	R:R:Y400	28.7352	3.09	Yes	Yes	1	8	8
23	R:R:H177	R:R:Y400	13.2163	13.07	No	Yes	0	9	8
24	R:R:E245	R:R:H177	17.047	13.54	No	No	0	9	9
25	R:R:E245	R:R:I176	38.6474	5.47	No	Yes	0	9	9
26	R:R:I176	R:R:Y248	13.1079	6.04	Yes	Yes	0	9	8
27	R:R:F184	R:R:N238	93.3092	21.75	Yes	No	0	8	9
28	R:R:N238	R:R:S183	92.9427	5.96	No	No	0	9	9
29	R:R:I176	R:R:W241	32.731	4.7	Yes	Yes	0	9	9
30	R:R:S183	R:R:W272	86.4584	2.47	No	Yes	2	9	9
31	R:R:M231	R:R:V191	12.3593	3.04	Yes	Yes	0	6	7
32	R:R:D195	R:R:I194	14.7909	2.8	Yes	No	0	7	6
33	R:R:D195	R:R:G196	10.5266	1.68	Yes	No	0	7	3
34	R:R:W272	R:R:Y233	81.0015	6.75	Yes	Yes	2	9	9
35	R:R:V279	R:R:Y233	46.1229	3.79	Yes	Yes	2	6	9
36	R:R:L307	R:R:V279	38.3789	4.47	No	Yes	2	7	6
37	R:R:L307	R:R:W304	41.1513	7.97	No	Yes	0	7	6
38	R:R:Q232	R:R:W304	15.6479	4.38	No	Yes	0	7	6
39	R:R:K286	R:R:Q232	14.1456	5.42	No	No	0	8	7
40	R:R:K286	R:R:Q293	12.6329	4.07	No	No	0	8	4
41	R:R:A237	R:R:W272	34.7651	2.59	No	Yes	2	7	9
42	R:R:P275	R:R:Y233	34.3882	9.74	Yes	Yes	2	9	9
43	R:R:A237	R:R:P275	33.7584	3.74	No	Yes	2	7	9
44	R:R:R308	R:R:W304	24.5121	3	No	Yes	0	6	6
45	R:R:L357	R:R:V396	20.5421	7.45	No	Yes	1	9	9
46	R:R:L357	R:R:L358	37.4393	5.54	No	Yes	0	9	9
47	R:R:L358	R:R:N318	27.5013	2.75	Yes	Yes	0	9	9
48	R:R:L357	R:R:Y400	17.6149	10.55	No	Yes	1	9	8
49	R:R:I321	R:R:N318	17.429	4.25	No	Yes	0	8	9
50	R:R:I355	R:R:L358	32.1631	2.85	No	Yes	0	8	9
51	R:R:H250	R:R:I321	14.1611	9.28	No	No	0	7	8
52	R:R:H250	R:R:R324	12.4264	3.39	No	No	0	7	8
53	R:R:A274	R:R:P275	61.8482	1.87	No	Yes	0	4	9
54	R:R:A274	R:R:F278	56.4171	4.16	No	Yes	0	4	5
55	R:R:F278	W:W:M10	39.8193	4.98	Yes	Yes	3	5	0
56	R:R:W282	W:W:M10	14.3211	4.65	Yes	Yes	3	9	0
57	R:R:I306	W:W:M10	22.9169	2.92	Yes	Yes	3	8	0
58	R:R:I306	W:W:S6	14.476	3.1	Yes	No	0	8	0
59	R:R:F312	R:R:R308	18.6061	13.9	No	No	0	5	6
60	R:R:F312	R:R:V363	17.1038	7.87	No	No	0	5	6
61	R:R:Q327	R:R:R324	10.6815	4.67	No	No	0	8	8
62	R:R:F322	R:R:I355	22.4109	5.02	No	No	0	9	8
63	R:R:F322	R:R:V326	14.0062	5.24	No	No	0	9	7
64	R:R:V326	R:R:V330	12.2819	1.6	No	No	0	7	6
65	R:R:R334	R:R:V330	10.5472	5.23	No	No	0	7	6
66	R:R:V363	R:R:V364	14.0681	1.6	No	No	0	6	6
67	R:R:F365	R:R:V364	12.5348	3.93	No	No	0	7	6
68	W:W:P3	W:W:S6	11.6004	5.34	No	No	0	0	0
69	R:R:A227	R:R:I194	12.602	1.62	No	No	0	6	6
70	R:R:A227	R:R:V193	10.5266	1.7	No	No	0	6	5
71	R:R:F391	R:R:S390	57.0573	3.96	Yes	No	0	7	9
72	R:R:V191	R:R:Y149	15.8183	20.19	Yes	Yes	0	7	8
73	R:R:F181	R:R:L163	22.4884	2.44	Yes	Yes	1	8	8
74	R:R:E245	R:R:L358	23.3505	3.98	No	Yes	0	9	9
75	R:R:W241	R:R:W272	29.8141	17.81	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L266	W:W:N15	2.75	0	No	No	3	0	1	0
R:R:A274	R:R:F278	4.16	0	No	Yes	4	5	1	1
R:R:F278	R:R:L277	2.44	3	Yes	No	5	4	1	1
R:R:L277	W:W:D11	5.43	0	No	No	4	0	1	0
R:R:F278	R:R:P310	14.45	3	Yes	No	5	9	1	1
R:R:F278	W:W:M10	4.98	3	Yes	Yes	5	0	1	0
R:R:V285	R:R:W282	3.68	0	No	Yes	5	9	2	1
R:R:I306	R:R:W282	8.22	3	Yes	Yes	8	9	1	1
R:R:W282	W:W:F5	8.02	3	Yes	No	9	0	1	0
R:R:W282	W:W:M10	4.65	3	Yes	Yes	9	0	1	0
R:R:I306	W:W:F5	6.28	3	Yes	No	8	0	1	0
R:R:I306	W:W:S6	3.1	3	Yes	No	8	0	1	0
R:R:I306	W:W:M10	2.92	3	Yes	Yes	8	0	1	0
R:R:F309	R:R:P310	2.89	0	No	No	4	9	1	1
R:R:F309	W:W:V9	3.93	0	No	No	4	0	1	0
R:R:P310	W:W:M10	3.35	3	No	Yes	9	0	1	0
R:R:A274	R:R:P275	1.87	0	No	Yes	4	9	1	2
R:R:A274	W:W:L13	1.58	0	No	No	4	0	1	0
R:R:F263	R:R:L266	1.22	0	No	No	5	3	2	1
R:R:W282	W:W:L8	1.14	3	Yes	No	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WG8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	248
Number of Links	269
Number of Hubs	36
Number of Links mediated by Hubs	132
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	44150
Length Of Smallest Path	3
Average Path Length	14.2285
Length of Longest Path	34
Minimum Path Strength	1.43
Average Path Strength	5.25889
Maximum Path Strength	16.145
Minimum Path Correlation	0.7
Average Path Correlation	0.949504
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.7984
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8481
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>8WG8_nogp_Chain_R A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A T L P E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W R L G K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	doi.org/10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	doi.org/10.1038/nature22363
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	doi.org/10.1038/nature17414
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	doi.org/10.1038/nature12393
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	doi.org/10.1038/nature25153
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		3.1	2020-08-12	doi.org/10.1126/science.aba3373
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WG8_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.