Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F569 3.798559
2R:R:S574 4.0625409
3R:R:V577 3.94453
4R:R:P578 3.466554
5R:R:L593 2.575658
6R:R:I597 3.03407
7R:R:L600 2.9825409
8R:R:R624 4.6465169
9R:R:L634 3.4125409
10R:R:D638 3.18507
11R:R:W640 6.545406
12R:R:C657 3.88254129
13R:R:F662 5.6154198
14R:R:F666 5.25407
15R:R:Y668 4.296508
16R:R:L669 3.07509
17R:R:F672 5.1409
18R:R:W674 6.085717119
19R:R:Y684 5.544208
20R:R:R685 8.5975408
21R:R:F690 3.958528
22R:R:P710 2.95509
23R:R:Y727 5.12754199
24R:R:C733 3.5254129
25R:R:W734 7.53254158
26R:R:P743 2.038508
27R:R:V762 1.49408
28R:R:K768 3.5375408
29R:R:H820 4.925458
30R:R:F823 5.51459
31R:R:N827 6.865409
32R:R:L835 4.475408
33R:R:F837 5.21408
34G:G:V16 2.6125407
35G:G:R27 2.91408
36G:G:V30 2.4425408
37G:G:Y40 4.51754136
38G:G:D48 4.966509
39G:G:L51 3.3325406
40G:G:N59 5.22549
41G:G:F61 3.565848
42A:A:L44 5.205409
43A:A:N50 4.2525409
44A:A:M60 4.41429
45A:A:G206 1.7725408
46A:A:F212 5.426529
47A:A:V214 3.385426
48A:A:F219 6.1625428
49A:A:M221 2.785428
50A:A:F222 7.226517
51A:A:F238 5.8475419
52A:A:D249 4.1475408
53A:A:Y253 5.562508
54A:A:W277 6.915406
55A:A:W281 6.332515
56A:A:F290 3.795629
57A:A:N292 4.395409
58A:A:E330 5.7025483
59A:A:V334 2.9225484
60A:A:K338 5.3825485
61A:A:Y339 4.6075483
62A:A:F340 7.195407
63A:A:R342 5.3975484
64A:A:F345 4.956508
65A:A:Y360 6.5125408
66A:A:F363 3.462585
67A:A:T364 4.406529
68A:A:N371 5.3175429
69A:A:R374 5.005424
70A:A:F376 2.93286728
71A:A:I382 4.28406
72A:A:I383 4.1825408
73A:A:R385 6.11595
74A:A:R389 3.975494
75A:A:Y391 4.86404
76B:B:I37 3.784102
77B:B:V40 3.6154103
78B:B:R48 6.735447
79B:B:H54 6.328336149
80B:B:K57 7.67419
81B:B:W63 6.195647
82B:B:S72 3.944149
83B:B:Q75 5.6025419
84B:B:D76 5.0754239
85B:B:K78 4.47408
86B:B:W82 5.828509
87B:B:Y85 9.96444
88B:B:K89 5.2945229
89B:B:I93 3.235407
90B:B:W99 5.68429719
91B:B:M101 4.71419
92B:B:Y105 5.002506
93B:B:N110 3.92404
94B:B:Y111 4.606504
95B:B:C114 2.56754248
96B:B:Y124 4.29406
97B:B:H142 6.25571719
98B:B:Y145 3.8918
99B:B:F151 4.3275409
100B:B:L152 3.114503
101B:B:S160 2.886566
102B:B:D163 7.765419
103B:B:W169 6.11143718
104B:B:F180 5.4567
105B:B:H183 5.15669
106B:B:D186 5.0525419
107B:B:F199 4.31669
108B:B:K209 8.66466
109B:B:W211 6.22667668
110B:B:F222 4.738538
111B:B:H225 6.30286739
112B:B:D228 6.205409
113B:B:I232 5.095438
114B:B:F235 5.857147136
115B:B:F241 4.995636
116B:B:T243 3.408538
117B:B:G244 2.2875435
118B:B:D247 5.57439
119B:B:R251 10.415408
120B:B:F253 5.586536
121B:B:R256 3.3625409
122B:B:D258 4.64437
123B:B:Y264 3.65714705
124B:B:H266 5.615404
125B:B:I273 4.06436
126B:B:F278 3.91407
127B:B:R283 5.746676109
128B:B:Y289 4.466537
129B:B:D290 4.07416
130B:B:N295 4.5575436
131B:B:W297 5.475438
132B:B:K301 6.2954105
133B:B:H311 7.248579
134B:B:R314 7.01833618
135B:B:V315 3.585477
136B:B:T321 6.2875447
137B:B:T329 3.84408
138B:B:S331 6.25479
139B:B:W332 8.445619
140B:B:D333 5.5725479
141B:B:K337 3.524576
142B:B:W339 4.722579
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F569 R:R:F823 19.75653.22YesYes599
2R:R:F823 R:R:G807 15.51133.01YesNo599
3R:R:G807 R:R:T810 14.97743.64NoNo597
4R:R:H820 R:R:T810 13.90592.74YesNo587
5R:R:F569 R:R:Y668 32.49142.06YesYes098
6R:R:D638 R:R:Y668 22.40683.45YesYes078
7R:R:L600 R:R:L634 10.724.15YesYes099
8R:R:D638 R:R:L634 16.56634.07YesYes079
9A:A:Y391 R:R:L682 90.03184.69YesNo049
10R:R:L682 R:R:V761 89.77482.98NoNo098
11R:R:G679 R:R:V761 89.51791.84NoNo098
12R:R:G679 R:R:L678 89.26081.71NoNo098
13R:R:C626 R:R:L678 84.36853.17NoNo078
14R:R:C626 R:R:W674 84.11062.61NoYes079
15R:R:M677 R:R:W674 82.04523.49NoYes069
16R:R:L705 R:R:M677 81.78694.24NoNo066
17R:R:C709 R:R:L705 81.52851.59NoNo086
18R:R:C709 R:R:F673 31.07464.19NoNo088
19R:R:F673 R:R:L669 30.81232.44NoYes089
20R:R:H665 R:R:L669 58.99735.14NoYes099
21R:R:F747 R:R:H665 58.46882.26NoNo089
22R:R:F747 R:R:Y668 57.94084.13NoYes088
23R:R:C709 R:R:P710 50.19721.88NoYes089
24R:R:L669 R:R:P710 30.83213.28YesYes099
25A:A:Y391 R:R:L681 47.85815.86YesNo047
26B:B:C317 B:B:S316 18.54571.72NoNo079
27B:B:S316 B:B:W332 18.71134.94NoYes099
28B:B:K57 B:B:W332 85.337612.76YesYes199
29B:B:K57 B:B:Q75 85.79316.78YesYes199
30A:A:C237 B:B:Q75 41.03264.58NoYes189
31A:A:C237 A:A:F238 41.09572.79NoYes189
32A:A:F238 A:A:L44 99.361510.96YesYes099
33A:A:L44 A:A:L46 99.63634.15YesNo098
34A:A:G47 A:A:L46 99.68191.71NoNo098
35A:A:G47 A:A:K53 99.7731.74NoNo099
36A:A:K53 A:A:L45 1005.64NoNo098
37A:A:L45 A:A:M221 92.69514.24NoYes088
38A:A:F212 A:A:M221 92.77852.49YesYes298
39A:A:F212 A:A:V214 23.50682.62YesYes296
40A:A:F376 A:A:V214 23.41112.62YesYes286
41A:A:F376 R:R:F690 46.66694.29YesYes288
42A:A:I383 R:R:F690 93.1823.77YesYes088
43A:A:H387 A:A:I383 98.31143.98NoYes088
44A:A:H387 R:R:R685 98.196910.16NoYes088
45R:R:R685 R:R:T619 48.310514.23YesNo088
46A:A:Y391 R:R:T619 47.81613.75YesNo048
47B:B:Q75 B:B:W99 42.96637.67YesYes199
48A:A:F238 B:B:W99 58.17387.02YesYes199
49A:A:F212 A:A:F219 70.065611.79YesYes298
50A:A:F219 A:A:F376 23.41132.14YesYes288
51A:A:F219 A:A:H41 23.33546.79YesNo286
52A:A:H41 R:R:F690 23.31555.66NoYes268
53A:A:F219 A:A:V217 23.33543.93YesNo285
54A:A:V217 R:R:F690 23.31553.93NoYes258
55R:R:L681 R:R:R685 48.97044.86NoYes078
56R:R:F666 R:R:P710 18.34615.78YesYes079
57B:B:L14 G:G:V16 11.132.98NoYes087
58B:B:L14 G:G:L19 12.43856.92NoNo089
59B:B:I18 G:G:L19 14.40091.43NoNo079
60B:B:I18 B:B:R22 16.36295.01NoNo076
61B:B:D258 B:B:R22 17.01692.38YesNo076
62B:B:D258 B:B:F222 26.81724.78YesYes378
63B:B:F222 B:B:F241 14.3826.43YesYes386
64B:B:F241 B:B:T243 17.63682.59YesYes368
65B:B:G244 B:B:T243 41.1441.82YesYes358
66B:B:G244 B:B:I273 48.07163.53YesYes356
67B:B:G272 B:B:I273 62.13361.76NoYes046
68B:B:C271 B:B:G272 63.09161.96NoNo054
69B:B:C271 B:B:D290 64.04964.67NoYes056
70A:A:W281 B:B:D290 32.12144.47YesYes156
71A:A:W281 B:B:W332 32.59962.81YesYes159
72B:B:F222 B:B:F253 14.39245.36YesYes386
73B:B:F253 B:B:T243 15.67592.59YesYes368
74B:B:D290 B:B:R314 32.2454.76YesYes168
75B:B:R314 B:B:W332 34.521319.99YesYes189
76B:B:L117 B:B:Y145 11.40112.34NoYes198
77B:B:L117 B:B:W99 13.12734.56NoYes199
78B:B:F235 B:B:F278 10.38116.43YesYes067
79B:B:C317 B:B:M61 10.60044.86NoNo076
80A:A:D249 A:A:K293 10.53918.3YesNo089
81A:A:K293 A:A:N292 10.65545.6NoYes099
82R:R:H820 R:R:P578 10.16523.05YesYes584
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WXW
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRF1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.84
Date 2022-09-28
D.O.I. 10.1038/s41467-022-33173-4
Net Summary
Imin 1.71
Number of Linked Nodes 841
Number of Links 991
Number of Hubs 142
Number of Links mediated by Hubs 543
Number of Communities 25
Number of Nodes involved in Communities 191
Number of Links involved in Communities 262
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 4975460
Length Of Smallest Path 3
Average Path Length 42.3533
Length of Longest Path 71
Minimum Path Strength 1.22
Average Path Strength 4.5726
Maximum Path Strength 16.375
Minimum Path Correlation 0.72
Average Path Correlation 0.993682
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 29.2023
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.5415
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T601
Sequence
>7WXW_Chain_R
TSFSILMSP FVPSTIFPV VKWITYVGL GISIGSLIL CLIIEALFW 
KQIKKSQTS HTRRICMVN IALSLLIAD VWFIVGATV DTTVNPSGV 
CTAAVFFTH FFYLSLFFW MLMLGILLA YRIILVFHH MAQHLMMAV 
GFCLGYGCP LIISVITIA VTQPSNTYK RKDVCWLNW SNGSKPLLA 
FVVPALAIV AVNFVVVLL VLTKLWRPA TIIRVGKSL LILTPLLGL 
TWGFGIGTI VDSQNLAWH VIFALLNAF QGFFILCFG ILLDSKLRQ 
LLFNKLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WXW_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WXW_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIYHT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WXW_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;23.42022-04-2710.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/&β;1/&γ;232022-04-2710.1038/s41586-022-04580-w
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.852022-09-2810.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.842022-09-2810.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;22.832022-09-2810.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/&β;1/&γ;23.092022-09-2810.1038/s41467-022-33173-4
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/&β;1/&γ;23.442023-05-1010.1038/s41467-023-38083-7




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