psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F25	R:R:Q23	18.74	No	No	0	7	3
2	R:R:C190	R:R:C24	7.28	No	No	0	3	5
3	R:R:E28	R:R:F25	9.33	No	No	0	4	7
4	R:R:E28	R:R:F32	36.15	No	No	3	4	2
5	R:R:E28	R:R:F33	4.66	No	Yes	3	4	6
6	R:R:F32	R:R:F33	5.36	No	Yes	3	2	6
7	R:R:F33	R:R:I192	3.77	Yes	No	0	6	1
8	R:R:F33	R:R:L201	20.7	Yes	No	0	6	1
9	R:R:K39	R:R:Y34	7.17	No	Yes	1	8	6
10	R:R:L41	R:R:Y34	3.52	No	Yes	0	2	6
11	R:R:T113	R:R:Y34	7.49	No	Yes	0	5	6
12	R:R:P200	R:R:Y34	5.56	No	Yes	0	6	6
13	L:L:?1	R:R:Y34	3.31	Yes	Yes	1	0	6
14	R:R:I192	R:R:R36	6.26	No	No	0	1	3
15	R:R:E193	R:R:R36	3.49	No	No	0	4	3
16	R:R:G38	R:R:S37	3.71	No	No	0	4	7
17	L:L:?1	R:R:K39	8.96	Yes	No	1	0	8
18	R:R:L41	R:R:R114	4.86	No	No	0	2	6
19	R:R:E44	R:R:N46	3.94	No	No	0	1	2
20	R:R:P111	R:R:W45	10.81	No	No	0	4	1
21	R:R:N46	R:R:S49	8.94	No	No	0	2	1
22	R:R:K294	R:R:V52	13.66	No	No	0	4	5
23	R:R:G56	R:R:M106	3.49	No	No	0	6	6
24	R:R:F103	R:R:I57	6.28	No	Yes	0	6	4
25	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
26	R:R:L298	R:R:V59	4.47	No	No	0	6	7
27	R:R:C60	R:R:Y102	4.03	No	Yes	0	6	7
28	R:R:C60	R:R:F103	6.98	No	No	0	6	6
29	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
30	R:R:I63	R:R:S304	3.1	Yes	No	0	8	9
31	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
32	R:R:F96	R:R:M64	11.2	No	No	0	7	6
33	R:R:L100	R:R:M64	4.24	No	No	0	4	6
34	R:R:A66	R:R:P308	3.74	No	No	0	8	9
35	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
36	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
37	R:R:F96	R:R:N67	3.62	No	Yes	0	7	9
38	R:R:N67	R:R:P308	6.52	Yes	No	0	9	9
39	R:R:I74	R:R:V70	3.07	No	No	0	7	9
40	R:R:A92	R:R:V70	3.39	No	No	0	9	9
41	R:R:A89	R:R:I74	6.5	No	No	0	7	7
42	R:R:F80	R:R:N77	9.67	Yes	No	4	8	6
43	R:R:N77	R:R:T321	7.31	No	No	4	6	7
44	R:R:F80	R:R:R79	4.28	Yes	No	0	8	6
45	R:R:F82	R:R:R79	4.28	No	No	0	7	6
46	R:R:F80	R:R:Y85	19.6	Yes	No	0	8	9
47	R:R:F80	R:R:M318	11.2	Yes	No	0	8	8
48	R:R:F80	R:R:T321	5.19	Yes	No	4	8	7
49	R:R:H81	R:R:Y86	18.51	No	No	0	8	4
50	R:R:F82	R:R:P83	4.33	No	No	0	7	6
51	R:R:M159	R:R:P83	5.03	No	No	0	6	6
52	R:R:P83	R:R:V164	5.3	No	No	0	6	7
53	R:R:I84	R:R:Y85	3.63	No	No	0	8	9
54	R:R:E145	R:R:I84	10.93	No	No	0	8	8
55	R:R:D315	R:R:Y85	5.75	No	No	0	8	9
56	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
57	R:R:V164	R:R:Y86	3.79	No	No	0	7	4
58	R:R:E145	R:R:L87	6.63	No	No	0	8	8
59	R:R:I142	R:R:M88	4.37	Yes	No	2	8	8
60	R:R:M88	R:R:Y311	5.99	No	Yes	2	8	9
61	R:R:N138	R:R:N90	12.26	Yes	No	0	8	9
62	R:R:I168	R:R:N90	12.74	No	No	0	8	9
63	R:R:N90	R:R:W172	6.78	No	No	0	9	9
64	R:R:D95	R:R:L91	4.07	Yes	Yes	0	9	9
65	R:R:L91	R:R:N138	6.87	Yes	Yes	0	9	8
66	R:R:L139	R:R:L91	4.15	Yes	Yes	2	8	9
67	R:R:I142	R:R:L91	4.28	Yes	Yes	2	8	9
68	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
69	R:R:A94	R:R:N138	3.13	No	Yes	0	8	8
70	R:R:D95	R:R:S304	5.89	Yes	No	0	9	9
71	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
72	R:R:F97	R:R:T130	3.89	No	No	0	7	6
73	R:R:F97	R:R:W172	6.01	No	No	0	7	9
74	R:R:A98	R:R:S131	3.42	No	No	0	8	6
75	R:R:A98	R:R:S304	3.42	No	No	0	8	9
76	R:R:A101	R:R:I128	3.25	No	No	0	5	6
77	R:R:A101	R:R:S131	3.42	No	No	0	5	6
78	R:R:L105	R:R:Y102	3.52	No	Yes	0	6	7
79	R:R:M106	R:R:Y102	5.99	No	Yes	0	6	7
80	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
81	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
82	R:R:E301	R:R:Y102	25.81	No	Yes	0	7	7
83	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
84	R:R:L105	R:R:R124	6.07	No	Yes	0	6	6
85	R:R:I128	R:R:L105	4.28	No	No	0	6	6
86	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
87	R:R:K294	R:R:T109	6.01	No	No	1	4	5
88	L:L:?1	R:R:T109	5.2	Yes	No	1	0	5
89	R:R:G110	R:R:P111	4.06	No	No	0	5	4
90	R:R:N112	R:R:R115	12.05	No	No	0	4	3
91	R:R:R124	R:R:T113	3.88	Yes	No	0	6	5
92	R:R:L116	R:R:W121	3.42	Yes	Yes	1	6	9
93	R:R:L116	R:R:R124	4.86	Yes	Yes	1	6	6
94	R:R:S119	R:R:T117	3.2	No	No	0	1	6
95	R:R:T117	R:R:T120	4.71	No	No	0	6	4
96	R:R:R124	R:R:W121	8	Yes	Yes	1	6	9
97	R:R:Q125	R:R:W121	15.33	Yes	Yes	1	4	9
98	R:R:P200	R:R:W121	5.4	No	Yes	0	6	9
99	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
100	R:R:L122	R:R:Y202	3.52	No	Yes	0	5	4
101	R:R:L123	R:R:L127	4.15	No	No	0	4	5
102	R:R:Q125	R:R:R124	9.35	Yes	Yes	1	4	6
103	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
104	R:R:Q125	R:R:Y202	5.64	Yes	Yes	1	4	4
105	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
106	R:R:D129	R:R:G126	3.35	Yes	No	0	5	6
107	R:R:D129	R:R:Y202	8.05	Yes	Yes	1	5	4
108	R:R:D129	R:R:Y206	8.05	Yes	Yes	1	5	7
109	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
110	R:R:I176	R:R:T130	4.56	No	No	0	3	6
111	R:R:L132	R:R:W210	3.42	No	Yes	1	7	6
112	R:R:L132	R:R:W271	6.83	No	Yes	1	7	8
113	R:R:E301	R:R:L132	6.63	No	No	0	7	7
114	R:R:A175	R:R:T133	3.36	No	No	0	8	6
115	R:R:M178	R:R:T133	4.52	Yes	No	1	5	6
116	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
117	R:R:A134	R:R:W172	3.89	No	No	0	7	9
118	R:R:N214	R:R:V136	7.39	Yes	Yes	1	7	8
119	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
120	R:R:F267	R:R:V136	5.24	Yes	Yes	1	9	8
121	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
122	R:R:A137	R:R:I171	4.87	No	No	0	5	7
123	R:R:I171	R:R:N138	9.91	No	Yes	0	7	8
124	R:R:L139	R:R:N307	8.24	Yes	No	0	8	9
125	R:R:L139	R:R:Y311	3.52	Yes	Yes	2	8	9
126	R:R:I144	R:R:L140	7.14	No	No	0	6	7
127	R:R:L140	R:R:T217	5.9	No	No	0	7	7
128	R:R:A141	R:R:I171	3.25	No	No	0	8	7
129	R:R:I142	R:R:R146	5.01	Yes	No	2	8	9
130	R:R:I142	R:R:Y311	6.04	Yes	Yes	2	8	9
131	R:R:R146	R:R:Y225	9.26	No	No	0	9	9
132	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
133	R:R:F151	R:R:H147	15.84	Yes	Yes	5	6	7
134	R:R:H147	R:R:L224	6.43	Yes	No	0	7	6
135	R:R:H147	R:R:H227	9.55	Yes	No	5	7	5
136	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
137	R:R:R152	R:R:T149	6.47	No	No	0	5	8
138	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
139	R:R:I228	R:R:V150	6.14	No	No	0	9	8
140	R:R:F151	R:R:H227	14.71	Yes	No	5	6	5
141	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
142	R:R:R152	R:R:T157	11.64	No	No	0	5	4
143	R:R:M159	R:R:R152	4.96	No	No	0	6	5
144	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
145	R:R:H156	R:R:L155	7.71	No	No	0	4	8
146	R:R:R162	R:R:S160	11.86	No	No	0	5	8
147	R:R:I181	R:R:V177	3.07	No	No	0	5	4
148	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
149	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
150	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
151	R:R:I181	R:R:P182	3.39	No	No	0	5	6
152	R:R:P182	R:R:Y202	13.91	No	Yes	1	6	4
153	R:R:P182	R:R:Y206	20.86	No	Yes	1	6	7
154	R:R:G185	R:R:V184	3.68	No	No	0	5	5
155	R:R:S205	R:R:W186	8.65	No	No	0	5	6
156	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
157	R:R:I189	R:R:N187	8.5	Yes	No	0	3	6
158	R:R:C188	R:R:C195	7.28	No	No	0	5	9
159	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
160	R:R:M198	R:R:S196	3.07	Yes	No	6	3	5
161	R:R:A199	R:R:S196	3.42	No	No	0	4	5
162	R:R:D281	R:R:S196	4.42	Yes	No	6	4	5
163	R:R:D281	R:R:N197	12.12	Yes	No	0	4	5
164	R:R:L277	R:R:M198	5.65	No	Yes	0	4	3
165	R:R:D281	R:R:M198	9.7	Yes	Yes	6	4	3
166	R:R:E293	R:R:M198	14.89	No	Yes	0	4	3
167	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
168	R:R:Y202	R:R:Y206	7.94	Yes	Yes	1	4	7
169	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
170	R:R:S203	R:R:S205	4.89	No	No	0	5	5
171	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
172	R:R:L207	R:R:L278	6.92	No	No	1	6	6
173	L:L:?1	R:R:L207	3.91	Yes	No	1	0	6
174	R:R:I212	R:R:V208	3.07	No	No	0	4	4
175	R:R:V208	R:R:V282	3.21	No	Yes	0	4	5
176	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
177	L:L:?1	R:R:W210	8.04	Yes	Yes	1	0	6
178	R:R:F213	R:R:T217	5.19	No	No	0	5	7
179	R:R:F267	R:R:N214	7.25	Yes	Yes	1	9	7
180	R:R:N214	R:R:W271	11.3	Yes	Yes	1	7	8
181	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
182	R:R:F218	R:R:V222	7.87	No	No	0	5	4
183	R:R:F218	R:R:F267	11.79	No	Yes	0	5	9
184	R:R:F218	R:R:I268	5.02	No	No	0	5	6
185	R:R:V260	R:R:Y225	6.31	No	No	0	8	9
186	R:R:V263	R:R:Y225	5.05	No	No	0	8	9
187	R:R:F229	R:R:M253	3.73	Yes	Yes	0	6	7
188	R:R:F229	R:R:L256	8.53	Yes	No	0	6	7
189	R:R:F229	R:R:L257	7.31	Yes	No	0	6	7
190	R:R:R235	R:R:Y231	12.35	No	No	0	7	6
191	R:R:L256	R:R:V232	4.47	No	No	0	7	7
192	R:R:D251	R:R:M253	4.16	No	Yes	0	5	7
193	R:R:R314	R:R:S255	9.22	Yes	No	0	7	7
194	R:R:T259	R:R:Y313	4.99	No	No	7	8	5
195	R:R:R314	R:R:T259	11.64	Yes	No	7	7	8
196	R:R:I262	R:R:Y313	7.25	No	No	0	6	5
197	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
198	R:R:F267	R:R:W271	17.04	Yes	Yes	1	9	8
199	R:R:I268	R:R:T272	6.08	No	No	0	6	5
200	R:R:C270	R:R:L299	3.17	No	No	0	9	7
201	R:R:C270	R:R:N303	9.45	No	No	0	9	9
202	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
203	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
204	R:R:P273	R:R:T272	3.5	Yes	No	0	9	5
205	R:R:F296	R:R:P273	8.67	No	Yes	0	5	9
206	R:R:L299	R:R:P273	3.28	No	Yes	0	7	9
207	R:R:F296	R:R:L277	7.31	No	No	0	5	4
208	L:L:?1	R:R:L278	4.88	Yes	No	1	0	6
209	R:R:L280	R:R:V289	4.47	No	No	0	5	4
210	R:R:D281	R:R:V289	4.38	Yes	No	0	4	4
211	R:R:C284	R:R:P285	3.77	No	No	0	4	3
212	R:R:C284	R:R:C287	7.28	No	No	0	4	5
213	R:R:A291	R:R:Y292	5.34	No	No	0	2	3
214	R:R:F296	R:R:Y292	4.13	No	No	0	5	3
215	L:L:?1	R:R:E293	23.38	Yes	No	0	0	4
216	L:L:?1	R:R:K294	6.97	Yes	No	1	0	4
217	L:L:?1	R:R:L297	15.63	Yes	No	0	0	6
218	R:R:F302	R:R:M306	12.44	No	No	0	5	6
219	R:R:N303	R:R:N307	6.81	No	No	0	9	9
220	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
221	R:R:M318	R:R:S312	6.13	No	No	0	8	7
222	R:R:R314	R:R:Y313	17.49	Yes	No	7	7	5
223	R:R:F322	R:R:M318	4.98	No	No	0	6	8
224	R:R:L87	R:R:V167	2.98	No	No	0	8	6
225	R:R:L140	R:R:V220	2.98	No	No	0	7	5
226	R:R:L207	R:R:V282	2.98	No	Yes	0	6	5
227	R:R:L224	R:R:V220	2.98	No	No	0	6	5
228	R:R:L264	R:R:V222	2.98	No	No	0	7	4
229	R:R:L257	R:R:V261	2.98	No	No	0	7	5
230	R:R:N77	R:R:V76	2.96	No	No	0	6	5
231	R:R:L41	R:R:T43	2.95	No	No	0	2	3
232	R:R:L116	R:R:T120	2.95	Yes	No	0	6	4
233	R:R:I57	R:R:I61	2.94	Yes	No	0	4	4
234	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
235	R:R:I262	R:R:I310	2.94	No	No	0	6	8
236	R:R:A42	R:R:H40	2.93	No	No	0	4	2
237	R:R:I84	R:R:M88	2.92	No	No	0	8	8
238	R:R:I30	R:R:L116	2.85	No	Yes	0	6	6
239	R:R:L139	R:R:M221	2.83	Yes	No	0	8	9
240	R:R:L264	R:R:M221	2.83	No	No	0	7	9
241	R:R:L298	R:R:L55	2.77	No	No	0	6	4
242	R:R:A305	R:R:F62	2.77	No	No	0	7	4
243	R:R:L65	R:R:L69	2.77	No	No	0	4	7
244	R:R:A305	R:R:F302	2.77	No	No	0	7	5
245	R:R:E317	R:R:K316	2.7	No	No	0	7	5
246	R:R:E193	R:R:N194	2.63	No	No	0	4	3
247	R:R:A300	R:R:W271	2.59	No	Yes	0	7	8
248	R:R:F107	R:R:I57	2.51	No	Yes	0	5	4
249	R:R:F107	R:R:M53	2.49	No	No	0	5	4
250	R:R:F213	R:R:M174	2.49	No	No	0	5	4
251	R:R:M253	R:R:R233	2.48	Yes	No	0	7	5
252	R:R:K258	R:R:R314	2.48	No	Yes	0	7	7
253	R:R:K316	R:R:R314	2.48	No	Yes	0	5	7
254	R:R:F97	R:R:L127	2.44	No	No	0	7	5
255	R:R:M153	R:R:Y231	2.39	No	No	0	7	6
256	R:R:N27	R:R:Y26	2.33	No	No	0	8	4
257	R:R:G274	R:R:P273	2.03	No	Yes	0	5	9
258	R:R:G110	R:R:S49	1.86	No	No	0	5	1
259	R:R:G110	R:R:T109	1.82	No	No	0	5	5
260	R:R:G179	R:R:T130	1.82	No	No	0	7	6
261	R:R:P200	R:R:S37	1.78	No	No	0	6	7
262	R:R:G54	R:R:I57	1.76	No	Yes	0	4	4
263	R:R:G265	R:R:I268	1.76	No	No	0	4	6
264	R:R:C195	R:R:S203	1.72	No	No	0	9	5
265	R:R:A31	R:R:S29	1.71	No	No	0	2	4
266	R:R:C283	R:R:V282	1.71	No	Yes	0	4	5
267	R:R:C287	R:R:V289	1.71	No	No	0	5	4
268	R:R:A73	R:R:T321	1.68	No	No	0	7	7
269	R:R:C24	R:R:I189	1.64	No	Yes	0	5	3
270	R:R:C270	R:R:I269	1.64	No	No	0	9	5
271	R:R:S49	R:R:V48	1.62	No	No	0	1	3
272	R:R:A143	R:R:M221	1.61	No	No	0	8	9
273	R:R:A266	R:R:M306	1.61	No	No	0	6	6
274	R:R:V150	R:R:V232	1.6	No	No	0	8	7
275	R:R:V164	R:R:V165	1.6	No	No	0	7	1
276	R:R:V216	R:R:V219	1.6	No	No	0	4	3
277	R:R:T236	R:R:V232	1.59	No	No	0	5	7
278	R:R:T272	R:R:V276	1.59	No	No	0	5	6
279	R:R:C283	R:R:L279	1.59	No	No	0	4	6
280	R:R:A211	R:R:L275	1.58	No	No	0	4	6
281	R:R:A211	R:R:L279	1.58	No	No	0	4	6
282	R:R:T236	R:R:T252	1.57	No	No	0	5	5
283	R:R:A42	R:R:N46	1.56	No	No	0	4	2
284	R:R:I189	R:R:V118	1.54	Yes	No	0	3	2
285	R:R:I212	R:R:V216	1.54	No	No	0	4	4
286	R:R:A291	R:R:D288	1.54	No	No	0	2	1
287	R:R:I57	R:R:T58	1.52	Yes	No	0	4	5
288	R:R:M174	R:R:V170	1.52	No	No	0	4	3
289	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
290	R:R:L122	R:R:S183	1.5	No	No	0	5	6
291	R:R:M237	R:R:M253	1.44	No	Yes	0	5	7
292	R:R:K39	R:R:L290	1.41	No	No	0	8	3
293	R:R:D251	R:R:M254	1.39	No	No	0	5	5
294	R:R:L51	R:R:L55	1.38	No	No	0	4	4
295	R:R:F295	R:R:V48	1.31	No	No	0	4	3
296	R:R:I148	R:R:R163	1.25	No	No	0	5	6
297	R:R:F96	R:R:L68	1.22	No	No	0	7	4
298	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
299	R:R:K50	R:R:W45	1.16	No	No	0	3	1
300	R:R:N112	R:R:W45	1.13	No	No	0	4	1
301	R:R:F322	R:R:R323	1.07	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F33	8.6225	4	3	6
2	R:R:Y34	4.70167	6	1	6
3	R:R:I57	3.002	5	0	4
4	R:R:I63	3.6775	4	0	8
5	R:R:N67	5.39	4	0	9
6	R:R:F80	9.988	5	4	8
7	R:R:L91	4.578	5	2	9
8	R:R:D95	5.542	5	0	9
9	R:R:Y102	9.29333	6	0	7
10	R:R:L116	3.52	4	1	6
11	R:R:W121	8.48	5	1	9
12	R:R:R124	6.73	7	1	6
13	R:R:Q125	9.46	4	1	4
14	R:R:D129	6.06	4	1	5
15	R:R:V136	5.5725	4	1	8
16	R:R:N138	8.0425	4	0	8
17	R:R:L139	4.685	4	2	8
18	R:R:I142	4.925	4	2	8
19	R:R:H147	9.28	4	5	7
20	R:R:F151	11.715	4	5	6
21	R:R:M178	4.145	4	1	5
22	R:R:I189	3.99	4	0	3
23	R:R:M198	8.3275	4	6	3
24	R:R:Y202	6.86	7	1	4
25	R:R:Y206	8.86	5	1	7
26	R:R:W210	5.14	5	1	6
27	R:R:N214	9.575	4	1	7
28	R:R:F229	5.27	4	0	6
29	R:R:M253	2.9525	4	0	7
30	R:R:F267	10.33	4	1	9
31	R:R:W271	7.4775	8	1	8
32	R:R:P273	4.37	4	0	9
33	R:R:D281	7.655	4	6	4
34	R:R:V282	4.165	4	0	5
35	R:R:Y311	5.02571	7	2	9
36	R:R:R314	8.662	5	7	7
37	L:L:?1	8.09769	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I189	R:R:L201	13.8547	4.28	Yes	No	0	3	1
2	R:R:F33	R:R:L201	24.5736	20.7	Yes	No	0	6	1
3	R:R:F33	R:R:I192	11.1129	3.77	Yes	No	0	6	1
4	R:R:L201	R:R:W121	40.177	10.25	No	Yes	0	1	9
5	R:R:R124	R:R:W121	21.6375	8	Yes	Yes	1	6	9
6	L:L:?1	R:R:R124	32.1244	7.72	Yes	Yes	1	0	6
7	R:R:Q125	R:R:W121	20.8333	15.33	Yes	Yes	1	4	9
8	L:L:?1	R:R:Q125	19.1062	7.52	Yes	Yes	1	0	4
9	R:R:G110	R:R:S49	11.4421	1.86	No	No	0	5	1
10	R:R:G110	R:R:T109	21.06	1.82	No	No	0	5	5
11	L:L:?1	R:R:T109	22.1934	5.2	Yes	No	1	0	5
12	R:R:C60	R:R:F103	13.3096	6.98	No	No	0	6	6
13	R:R:C60	R:R:Y102	15.2148	4.03	No	Yes	0	6	7
14	R:R:F103	R:R:I57	11.3936	6.28	No	Yes	0	6	4
15	R:R:L298	R:R:Y102	16.4994	7.03	No	Yes	0	6	7
16	R:R:L298	R:R:V59	15.3497	4.47	No	No	0	6	7
17	R:R:I63	R:R:V59	15.0583	3.07	Yes	No	0	8	7
18	R:R:I63	R:R:S304	17.514	3.1	Yes	No	0	8	9
19	L:L:?1	R:R:W210	86.9657	8.04	Yes	Yes	1	0	6
20	R:R:W210	R:R:W271	95.5419	4.69	Yes	Yes	1	6	8
21	R:R:N303	R:R:W271	98.2783	7.91	No	Yes	0	9	8
22	R:R:N303	R:R:N307	100	6.81	No	No	0	9	9
23	R:R:D95	R:R:N307	34.4398	8.08	Yes	No	0	9	9
24	R:R:D95	R:R:N67	18.9929	6.73	Yes	Yes	0	9	9
25	R:R:L139	R:R:N307	66.6343	8.24	Yes	No	0	8	9
26	R:R:L139	R:R:Y311	48.6507	3.52	Yes	Yes	2	8	9
27	R:R:M88	R:R:Y311	42.1146	5.99	No	Yes	2	8	9
28	R:R:I84	R:R:M88	50.1403	2.92	No	No	0	8	8
29	R:R:I84	R:R:Y85	43.6313	3.63	No	No	0	8	9
30	R:R:F80	R:R:Y85	40.1716	19.6	Yes	No	0	8	9
31	R:R:F80	R:R:R79	24.1904	4.28	Yes	No	0	8	6
32	R:R:F82	R:R:R79	22.3338	4.28	No	No	0	7	6
33	R:R:F82	R:R:P83	20.4663	4.33	No	No	0	7	6
34	R:R:D95	R:R:L91	38.4013	4.07	Yes	Yes	0	9	9
35	R:R:I142	R:R:L91	12.106	4.28	Yes	Yes	2	8	9
36	R:R:L139	R:R:L91	18.1671	4.15	Yes	Yes	2	8	9
37	R:R:L91	R:R:N138	39.6427	6.87	Yes	Yes	0	9	8
38	R:R:N138	R:R:N90	26.5814	12.26	Yes	No	0	8	9
39	R:R:N90	R:R:W172	21.2813	6.78	No	No	0	9	9
40	R:R:F97	R:R:W172	15.938	6.01	No	No	0	7	9
41	L:L:?1	R:R:L297	11.4206	15.63	Yes	No	0	0	6
42	R:R:E301	R:R:Y102	10.5462	25.81	No	Yes	0	7	7
43	R:R:M178	R:R:W210	11.3936	3.49	Yes	Yes	1	5	6
44	R:R:V136	R:R:W271	60.3951	4.9	Yes	Yes	1	8	8
45	R:R:T217	R:R:V136	64.0976	4.76	No	Yes	0	7	8
46	R:R:L140	R:R:T217	58.8515	5.9	No	No	0	7	7
47	R:R:F151	R:R:H147	27.6015	15.84	Yes	Yes	5	6	7
48	R:R:H147	R:R:L224	53.3895	6.43	Yes	No	0	7	6
49	R:R:L224	R:R:V220	54.8035	2.98	No	No	0	6	5
50	R:R:L140	R:R:V220	56.1636	2.98	No	No	0	7	5
51	R:R:H147	R:R:I228	23.0408	5.3	Yes	No	0	7	9
52	R:R:F151	R:R:V150	21.8534	3.93	Yes	No	0	6	8
53	R:R:I228	R:R:V150	21.7185	6.14	No	No	0	9	8
54	R:R:W186	R:R:Y206	10.87	3.86	No	Yes	0	6	7
55	L:L:?1	R:R:E293	20.0831	23.38	Yes	No	0	0	4
56	R:R:E293	R:R:M198	18.8957	14.89	No	Yes	0	4	3
57	R:R:D281	R:R:M198	10.951	9.7	Yes	Yes	6	4	3
58	R:R:L207	R:R:V282	11.4367	2.98	No	Yes	0	6	5
59	L:L:?1	R:R:L207	12.8454	3.91	Yes	No	1	0	6
60	R:R:F229	R:R:L256	28.7835	8.53	Yes	No	0	6	7
61	R:R:L256	R:R:V232	31.5792	4.47	No	No	0	7	7
62	R:R:V150	R:R:V232	40.4361	1.6	No	No	0	8	7
63	R:R:F229	R:R:M253	16.0838	3.73	Yes	Yes	0	6	7
64	R:R:I310	R:R:Y311	14.0382	3.63	No	Yes	0	8	9
65	R:R:I262	R:R:I310	12.4622	2.94	No	No	0	6	8
66	R:R:I262	R:R:Y313	11.1075	7.25	No	No	0	6	5
67	R:R:C270	R:R:N303	11.8253	9.45	No	No	0	9	9
68	R:R:L297	R:R:Y102	10.3519	9.38	No	Yes	0	6	7
69	R:R:D95	R:R:S304	21.9829	5.89	Yes	No	0	9	9
70	R:R:E301	R:R:L132	11.2047	6.63	No	No	0	7	7
71	L:L:?1	R:R:Y202	12.6781	4.96	Yes	Yes	1	0	4
72	L:L:?1	R:R:Y34	12.5	3.31	Yes	Yes	1	0	6
73	R:R:L91	R:R:Y311	13.8925	3.52	Yes	Yes	2	9	9
74	R:R:L132	R:R:W271	10.9618	6.83	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K39	R:R:Y34	7.17	1	No	Yes	8	6	1	1
R:R:L41	R:R:Y34	3.52	0	No	Yes	2	6	2	1
R:R:T113	R:R:Y34	7.49	0	No	Yes	5	6	2	1
R:R:P200	R:R:Y34	5.56	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	3.31	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	8.96	1	Yes	No	0	8	0	1
R:R:K294	R:R:V52	13.66	1	No	No	4	5	1	2
R:R:L105	R:R:Y102	3.52	0	No	Yes	6	7	2	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	7.23	0	No	Yes	5	6	2	1
R:R:K294	R:R:T109	6.01	1	No	No	4	5	1	1
L:L:?1	R:R:T109	5.2	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	2
R:R:L116	R:R:W121	3.42	1	Yes	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	Yes	Yes	6	6	2	1
R:R:R124	R:R:W121	8	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	Yes	Yes	4	9	1	2
R:R:P200	R:R:W121	5.4	0	No	Yes	6	9	2	2
R:R:L122	R:R:Y202	3.52	0	No	Yes	5	4	2	1
R:R:Q125	R:R:R124	9.35	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	5.64	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
R:R:D129	R:R:G126	3.35	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	8.05	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	8.05	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:W210	3.42	1	No	Yes	7	6	2	1
R:R:L132	R:R:W271	6.83	1	No	Yes	7	8	2	2
R:R:M178	R:R:T133	4.52	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	13.91	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	20.86	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	0	No	Yes	4	3	1	2
R:R:A199	R:R:Y202	4	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	7.94	1	Yes	Yes	4	7	1	2
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
R:R:L207	R:R:L278	6.92	1	No	No	6	6	1	1
L:L:?1	R:R:L207	3.91	1	Yes	No	0	6	0	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	8.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	4.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	23.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	15.63	1	Yes	No	0	6	0	1
R:R:L207	R:R:V282	2.98	1	No	Yes	6	5	1	2
R:R:G110	R:R:T109	1.82	0	No	No	5	5	2	1
R:R:K39	R:R:L290	1.41	1	No	No	8	3	1	2
R:R:N35	R:R:Y34	1.16	0	No	Yes	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	269
Number of Links	301
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	7
Number of Nodes involved in Communities	45
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	47599
Length Of Smallest Path	3
Average Path Length	12.3272
Length of Longest Path	30
Minimum Path Strength	1.145
Average Path Strength	6.41454
Maximum Path Strength	22.74
Minimum Path Correlation	0.7
Average Path Correlation	0.924844
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	51.8514
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5955
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU3_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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