psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K39	5.04	Yes	Yes	1	0	8
2	L:L:?1	R:R:T109	9.49	Yes	No	0	0	5
3	L:L:?1	R:R:T113	4.22	Yes	No	0	0	5
4	L:L:?1	R:R:R124	6.95	Yes	Yes	0	0	6
5	L:L:?1	R:R:Q125	10.48	Yes	Yes	1	0	4
6	L:L:?1	R:R:D129	4.86	Yes	Yes	1	0	5
7	L:L:?1	R:R:M198	5.06	Yes	Yes	1	0	3
8	L:L:?1	R:R:W210	19.56	Yes	No	1	0	6
9	L:L:?1	R:R:L278	4.95	Yes	No	0	0	6
10	L:L:?1	R:R:E293	7.59	Yes	Yes	1	0	4
11	R:R:I30	R:R:W121	4.7	No	Yes	0	6	9
12	R:R:F32	R:R:F33	6.43	Yes	No	0	2	6
13	R:R:F32	R:R:R36	7.48	Yes	No	3	2	3
14	R:R:F32	R:R:I192	5.02	Yes	No	3	2	1
15	R:R:F33	R:R:I189	3.77	No	Yes	0	6	3
16	R:R:F33	R:R:L201	9.74	No	No	0	6	1
17	R:R:K39	R:R:Y34	10.75	Yes	Yes	1	8	6
18	R:R:L41	R:R:Y34	4.69	No	Yes	0	2	6
19	R:R:T113	R:R:Y34	3.75	No	Yes	0	5	6
20	R:R:W121	R:R:Y34	7.72	Yes	Yes	0	9	6
21	R:R:P200	R:R:Y34	16.69	No	Yes	1	6	6
22	R:R:I192	R:R:R36	7.52	No	No	3	1	3
23	R:R:P200	R:R:S37	7.13	No	No	0	6	7
24	R:R:K39	R:R:P200	3.35	Yes	No	1	8	6
25	R:R:K39	R:R:L290	5.64	Yes	No	1	8	3
26	R:R:E293	R:R:K39	5.4	Yes	Yes	1	4	8
27	R:R:L41	R:R:R114	3.64	No	No	0	2	6
28	R:R:E44	R:R:T43	4.23	No	No	0	1	3
29	R:R:K50	R:R:W45	3.48	No	Yes	0	3	1
30	R:R:M53	R:R:W45	4.65	Yes	Yes	0	4	1
31	R:R:P111	R:R:W45	25.67	No	Yes	0	4	1
32	R:R:K294	R:R:V52	4.55	No	No	0	4	5
33	R:R:F295	R:R:V52	3.93	No	No	0	4	5
34	R:R:I57	R:R:M53	4.37	No	Yes	0	4	4
35	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
36	R:R:L298	R:R:V59	4.47	No	No	0	6	7
37	R:R:C60	R:R:Y102	4.03	No	Yes	0	6	7
38	R:R:C60	R:R:F103	4.19	No	No	0	6	6
39	R:R:A66	R:R:F62	5.55	No	No	0	8	4
40	R:R:I63	R:R:S304	3.1	Yes	No	0	8	9
41	R:R:F96	R:R:M64	6.22	No	No	0	7	6
42	R:R:A92	R:R:N67	3.13	No	No	0	9	9
43	R:R:D95	R:R:N67	6.73	Yes	No	0	9	9
44	R:R:N67	R:R:P308	9.77	No	No	0	9	9
45	R:R:F322	R:R:L69	9.74	No	No	0	6	7
46	R:R:S312	R:R:V70	3.23	No	No	0	7	9
47	R:R:V72	R:R:V76	3.21	No	No	0	5	5
48	R:R:I325	R:R:V72	3.07	No	No	0	6	5
49	R:R:A73	R:R:T321	3.36	No	No	0	7	7
50	R:R:N77	R:R:R79	4.82	Yes	No	4	6	6
51	R:R:F80	R:R:N77	10.87	Yes	Yes	4	8	6
52	R:R:E317	R:R:N77	11.83	No	Yes	4	7	6
53	R:R:N77	R:R:T321	5.85	Yes	No	0	6	7
54	R:R:E317	R:R:R79	25.59	No	No	4	7	6
55	R:R:F80	R:R:Y85	14.44	Yes	Yes	0	8	9
56	R:R:E317	R:R:F80	16.32	No	Yes	4	7	8
57	R:R:F80	R:R:M318	7.46	Yes	No	0	8	8
58	R:R:H81	R:R:Y86	3.27	No	No	0	8	4
59	R:R:F82	R:R:Y85	4.13	No	Yes	0	7	9
60	R:R:F82	R:R:T157	7.78	No	No	0	7	4
61	R:R:H156	R:R:P83	10.68	Yes	No	0	4	6
62	R:R:N161	R:R:P83	3.26	No	No	0	3	6
63	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
64	R:R:H156	R:R:I84	7.95	Yes	No	0	4	8
65	R:R:D315	R:R:Y85	9.2	No	Yes	0	8	9
66	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
67	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
68	R:R:M88	R:R:Y311	5.99	No	Yes	0	8	9
69	R:R:N138	R:R:N90	13.62	No	No	0	8	9
70	R:R:I168	R:R:N90	14.16	No	No	0	8	9
71	R:R:N90	R:R:W172	7.91	No	Yes	0	9	9
72	R:R:D95	R:R:L91	5.43	Yes	No	2	9	9
73	R:R:L91	R:R:N138	8.24	No	No	0	9	8
74	R:R:L91	R:R:N307	5.49	No	Yes	2	9	9
75	R:R:D95	R:R:S135	4.42	Yes	No	0	9	9
76	R:R:D95	R:R:S304	8.83	Yes	No	0	9	9
77	R:R:D95	R:R:N307	6.73	Yes	Yes	2	9	9
78	R:R:F96	R:R:L100	6.09	No	No	0	7	4
79	R:R:A98	R:R:S131	3.42	No	No	0	8	6
80	R:R:A98	R:R:S304	3.42	No	No	0	8	9
81	R:R:A101	R:R:S131	3.42	No	No	0	5	6
82	R:R:M106	R:R:Y102	9.58	No	Yes	0	6	7
83	R:R:L297	R:R:Y102	5.86	No	Yes	0	6	7
84	R:R:L298	R:R:Y102	5.86	No	Yes	0	6	7
85	R:R:E301	R:R:Y102	17.96	No	Yes	0	7	7
86	R:R:N108	R:R:Y104	8.14	No	No	0	5	5
87	R:R:L105	R:R:R124	4.86	No	Yes	0	6	6
88	R:R:N108	R:R:N112	4.09	No	No	0	5	4
89	R:R:L116	R:R:N108	5.49	No	No	0	6	5
90	R:R:G110	R:R:P111	4.06	No	No	0	5	4
91	R:R:N112	R:R:R115	14.46	No	No	0	4	3
92	R:R:L116	R:R:R124	4.86	No	Yes	0	6	6
93	R:R:T117	R:R:T120	4.71	No	No	0	6	4
94	R:R:I189	R:R:V118	3.07	Yes	No	0	3	2
95	R:R:L201	R:R:V118	4.47	No	No	0	1	2
96	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
97	R:R:R124	R:R:W121	5	Yes	Yes	0	6	9
98	R:R:Q125	R:R:W121	7.67	Yes	Yes	0	4	9
99	R:R:L201	R:R:W121	13.67	No	Yes	0	1	9
100	R:R:L122	R:R:Y202	3.52	No	Yes	0	5	4
101	R:R:D129	R:R:Q125	3.92	Yes	Yes	1	5	4
102	R:R:Q125	R:R:Y202	9.02	Yes	Yes	1	4	4
103	R:R:D129	R:R:Y202	4.6	Yes	Yes	1	5	4
104	R:R:D129	R:R:Y206	4.6	Yes	Yes	1	5	7
105	R:R:L132	R:R:W271	5.69	No	Yes	0	7	8
106	R:R:A175	R:R:T133	3.36	No	Yes	0	8	6
107	R:R:M178	R:R:T133	6.02	No	Yes	1	5	6
108	R:R:T133	R:R:W210	7.28	Yes	No	1	6	6
109	R:R:F213	R:R:T133	5.19	No	Yes	1	5	6
110	R:R:A134	R:R:W172	3.89	No	Yes	0	7	9
111	R:R:F213	R:R:V136	5.24	No	No	1	5	8
112	R:R:T217	R:R:V136	4.76	No	No	1	7	8
113	R:R:V136	R:R:W271	3.68	No	Yes	1	8	8
114	R:R:A137	R:R:I171	3.25	No	No	0	5	7
115	R:R:I171	R:R:N138	7.08	No	No	0	7	8
116	R:R:L139	R:R:N307	5.49	No	Yes	2	8	9
117	R:R:L139	R:R:Y311	3.52	No	Yes	2	8	9
118	R:R:L140	R:R:T217	7.37	No	No	0	7	7
119	R:R:I142	R:R:R146	5.01	No	No	2	8	9
120	R:R:I142	R:R:Y311	3.63	No	Yes	2	8	9
121	R:R:A143	R:R:Y225	5.34	No	No	0	8	9
122	R:R:E145	R:R:H156	3.69	Yes	Yes	0	8	4
123	R:R:E145	R:R:R163	10.47	Yes	No	0	8	6
124	R:R:E145	R:R:V164	4.28	Yes	No	0	8	7
125	R:R:R146	R:R:Y225	9.26	No	No	0	9	9
126	R:R:R146	R:R:Y311	4.12	No	Yes	2	9	9
127	R:R:F151	R:R:H147	11.31	Yes	Yes	5	6	7
128	R:R:H147	R:R:L224	6.43	Yes	No	0	7	6
129	R:R:H147	R:R:H227	9.55	Yes	No	5	7	5
130	R:R:H147	R:R:I228	3.98	Yes	No	0	7	9
131	R:R:I148	R:R:R163	7.52	No	No	0	5	6
132	R:R:H156	R:R:T149	10.95	Yes	No	0	4	8
133	R:R:M159	R:R:T149	4.52	No	No	0	6	8
134	R:R:F151	R:R:V150	5.24	Yes	No	0	6	8
135	R:R:F151	R:R:H227	12.44	Yes	No	5	6	5
136	R:R:F151	R:R:Y231	17.54	Yes	No	0	6	6
137	R:R:M159	R:R:Q154	9.52	No	No	0	6	4
138	R:R:L155	R:R:R158	6.07	No	No	0	8	3
139	R:R:I168	R:R:V164	3.07	No	No	0	8	7
140	R:R:I171	R:R:V167	3.07	No	No	0	7	6
141	R:R:M178	R:R:W210	3.49	No	No	1	5	6
142	R:R:I181	R:R:P182	3.39	No	No	0	5	6
143	R:R:I181	R:R:W186	4.7	No	Yes	0	5	6
144	R:R:P182	R:R:Y202	9.74	No	Yes	1	6	4
145	R:R:P182	R:R:Y206	9.74	No	Yes	1	6	7
146	R:R:S205	R:R:W186	6.18	No	Yes	0	5	6
147	R:R:W186	R:R:Y206	5.79	Yes	Yes	0	6	7
148	R:R:F209	R:R:W186	10.02	No	Yes	0	6	6
149	R:R:I189	R:R:N187	5.66	Yes	No	0	3	6
150	R:R:C188	R:R:C195	7.28	No	No	6	5	9
151	R:R:D191	R:R:E193	5.2	No	No	3	4	4
152	R:R:D191	R:R:N194	12.12	No	No	3	4	3
153	R:R:E193	R:R:N194	3.94	No	No	3	4	3
154	R:R:L207	R:R:S196	6.01	No	No	0	6	5
155	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
156	R:R:D281	R:R:N197	9.42	Yes	No	0	4	5
157	R:R:D281	R:R:M198	8.32	Yes	Yes	1	4	3
158	R:R:M198	R:R:V289	4.56	Yes	No	1	3	4
159	R:R:E293	R:R:M198	6.77	Yes	Yes	1	4	3
160	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
161	R:R:Y202	R:R:Y206	5.96	Yes	Yes	1	4	7
162	R:R:S203	R:R:S205	4.89	Yes	No	0	5	5
163	R:R:V208	R:R:V282	4.81	No	No	0	4	5
164	R:R:A211	R:R:L279	3.15	No	No	0	4	6
165	R:R:F213	R:R:T217	3.89	No	No	1	5	7
166	R:R:F267	R:R:N214	7.25	No	No	1	9	7
167	R:R:N214	R:R:W271	3.39	No	Yes	1	7	8
168	R:R:L275	R:R:N214	6.87	No	No	0	6	7
169	R:R:L215	R:R:L275	5.54	No	No	0	5	6
170	R:R:F218	R:R:V222	7.87	No	No	0	5	4
171	R:R:F218	R:R:F267	12.86	No	No	0	5	9
172	R:R:F218	R:R:I268	6.28	No	No	0	5	6
173	R:R:L264	R:R:V222	4.47	No	No	0	7	4
174	R:R:V263	R:R:Y225	3.79	Yes	No	0	8	9
175	R:R:F229	R:R:R233	3.21	Yes	No	0	6	5
176	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
177	R:R:F229	R:R:L257	12.18	Yes	No	0	6	7
178	R:R:M253	R:R:R233	3.72	Yes	No	0	7	5
179	R:R:Q234	R:R:R235	5.84	No	No	0	4	7
180	R:R:R235	R:R:R238	4.26	No	No	0	7	5
181	R:R:R248	R:R:T236	7.76	Yes	No	0	4	5
182	R:R:M239	R:R:R248	4.96	No	Yes	0	7	4
183	R:R:H242	R:R:R241	18.05	No	No	0	4	4
184	R:R:R248	R:R:S243	11.86	Yes	No	0	4	3
185	R:R:G245	R:R:P246	4.06	No	No	0	1	4
186	R:R:R247	R:R:R248	3.2	No	Yes	0	3	4
187	R:R:M254	R:R:R250	3.72	No	No	0	5	4
188	R:R:R314	R:R:T259	11.64	No	No	0	7	8
189	R:R:I262	R:R:I310	4.42	No	Yes	0	6	8
190	R:R:I310	R:R:V263	3.07	Yes	Yes	2	8	8
191	R:R:V263	R:R:Y311	5.05	Yes	Yes	2	8	9
192	R:R:F267	R:R:W271	11.02	No	Yes	1	9	8
193	R:R:I268	R:R:T272	6.08	No	No	0	6	5
194	R:R:C270	R:R:N303	7.87	No	No	0	9	9
195	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
196	R:R:N303	R:R:W271	9.04	No	Yes	0	9	8
197	R:R:P273	R:R:T272	5.25	No	No	0	9	5
198	R:R:F296	R:R:P273	8.67	No	No	0	5	9
199	R:R:F296	R:R:L277	8.53	No	No	0	5	4
200	R:R:D281	R:R:V289	4.38	Yes	No	1	4	4
201	R:R:C284	R:R:C287	7.28	No	No	1	4	5
202	R:R:E293	R:R:L290	3.98	Yes	No	1	4	3
203	R:R:F296	R:R:Y292	6.19	No	No	0	5	3
204	R:R:F302	R:R:M306	4.98	No	No	0	5	6
205	R:R:N303	R:R:N307	5.45	No	Yes	0	9	9
206	R:R:N307	R:R:Y311	3.49	Yes	Yes	2	9	9
207	R:R:I310	R:R:Y311	7.25	Yes	Yes	2	8	9
208	R:R:M318	R:R:S312	4.6	No	No	0	8	7
209	R:R:R314	R:R:Y313	12.35	No	No	0	7	5
210	R:R:A320	R:R:K316	3.21	No	No	0	4	5
211	R:R:F322	R:R:M318	6.22	No	No	0	6	8
212	R:R:K316	R:R:S319	3.06	No	No	0	5	8
213	R:R:I176	R:R:T130	3.04	No	No	0	3	6
214	R:R:M253	R:R:V232	3.04	Yes	No	0	7	7
215	R:R:F97	R:R:W172	3.01	No	Yes	0	7	9
216	R:R:F229	R:R:G230	3.01	Yes	No	0	6	2
217	R:R:M253	R:R:T236	3.01	Yes	No	0	7	5
218	R:R:M253	R:R:T252	3.01	Yes	No	0	7	5
219	R:R:N46	R:R:S49	2.98	No	No	0	2	1
220	R:R:L140	R:R:V220	2.98	No	No	0	7	5
221	R:R:L264	R:R:V260	2.98	No	No	0	7	8
222	R:R:L280	R:R:V276	2.98	No	No	0	5	6
223	R:R:I144	R:R:I148	2.94	No	No	0	6	5
224	R:R:D204	R:R:S203	2.94	No	Yes	0	4	5
225	R:R:N46	R:R:T47	2.92	No	No	0	2	5
226	R:R:D204	R:R:V282	2.92	No	No	0	4	5
227	R:R:I61	R:R:L65	2.85	No	No	0	4	4
228	R:R:I128	R:R:L105	2.85	No	No	0	6	6
229	R:R:I144	R:R:L224	2.85	No	No	0	6	6
230	R:R:L68	R:R:M71	2.83	No	No	0	4	7
231	R:R:L264	R:R:M221	2.83	No	No	0	7	9
232	R:R:L298	R:R:L55	2.77	No	No	0	6	4
233	R:R:L326	R:R:L69	2.77	No	No	0	6	7
234	R:R:A305	R:R:F302	2.77	No	No	0	7	5
235	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
236	R:R:R114	R:R:T43	2.59	No	No	0	6	3
237	R:R:A94	R:R:W172	2.59	No	Yes	0	8	9
238	R:R:F97	R:R:T130	2.59	No	No	0	7	6
239	R:R:F103	R:R:I57	2.51	No	No	0	6	4
240	R:R:F62	R:R:I309	2.51	No	No	0	4	7
241	R:R:F80	R:R:I74	2.51	Yes	No	0	8	7
242	R:R:F107	R:R:M53	2.49	No	Yes	0	5	4
243	R:R:S49	R:R:W45	2.47	No	Yes	0	1	1
244	L:L:?1	R:R:G274	2.45	Yes	No	0	0	5
245	R:R:F295	R:R:L51	2.44	No	No	0	4	4
246	R:R:F97	R:R:L127	2.44	No	No	0	7	5
247	R:R:L123	R:R:Y104	2.34	No	No	0	4	5
248	R:R:R238	R:R:R241	2.13	No	No	0	5	4
249	R:R:R235	R:R:Y231	2.06	No	No	0	7	6
250	R:R:A42	R:R:G110	1.95	No	No	0	4	5
251	R:R:C284	R:R:P285	1.88	No	No	0	4	3
252	R:R:G56	R:R:V59	1.84	No	No	0	6	7
253	R:R:G179	R:R:T130	1.82	No	No	0	7	6
254	R:R:G99	R:R:I63	1.76	No	Yes	0	7	8
255	R:R:G54	R:R:M53	1.75	No	Yes	0	4	4
256	R:R:G99	R:R:M64	1.75	No	No	0	7	6
257	R:R:C188	R:R:S203	1.72	No	Yes	6	5	5
258	R:R:C195	R:R:S203	1.72	No	Yes	6	9	5
259	R:R:A31	R:R:S29	1.71	No	No	0	2	4
260	R:R:A180	R:R:S183	1.71	No	No	0	4	6
261	R:R:C287	R:R:V289	1.71	No	No	1	5	4
262	R:R:A141	R:R:V167	1.7	No	No	0	8	6
263	R:R:G185	R:R:N187	1.7	No	No	0	5	6
264	R:R:D129	R:R:G126	1.68	Yes	No	0	5	6
265	R:R:C190	R:R:I189	1.64	No	Yes	0	3	3
266	R:R:C270	R:R:I269	1.64	No	No	0	9	5
267	R:R:L299	R:R:P273	1.64	No	No	0	7	9
268	R:R:A305	R:R:I63	1.62	No	Yes	0	7	8
269	R:R:A73	R:R:I325	1.62	No	No	0	7	6
270	R:R:A89	R:R:I74	1.62	No	No	0	7	7
271	R:R:S183	R:R:V184	1.62	No	No	0	6	5
272	R:R:A266	R:R:I310	1.62	No	Yes	0	6	8
273	R:R:C270	R:R:M306	1.62	No	No	0	9	6
274	R:R:A92	R:R:M71	1.61	No	No	0	9	7
275	R:R:A93	R:R:M71	1.61	No	No	0	6	7
276	R:R:A137	R:R:M174	1.61	No	No	0	5	4
277	R:R:V48	R:R:V52	1.6	No	No	0	3	5
278	R:R:S119	R:R:T117	1.6	No	No	0	1	6
279	R:R:V169	R:R:V170	1.6	No	No	0	4	3
280	R:R:V216	R:R:V220	1.6	No	No	0	4	5
281	R:R:T259	R:R:V263	1.59	No	Yes	0	8	8
282	R:R:C284	R:R:L280	1.59	No	No	1	4	5
283	R:R:C287	R:R:L280	1.59	No	No	1	5	5
284	R:R:A31	R:R:N35	1.56	No	No	0	2	7
285	R:R:I181	R:R:V177	1.54	No	No	0	5	4
286	R:R:I212	R:R:V216	1.54	No	No	0	4	4
287	R:R:I228	R:R:V232	1.54	No	No	0	9	7
288	R:R:A291	R:R:D288	1.54	No	No	0	2	1
289	R:R:K294	R:R:S49	1.53	No	No	0	4	1
290	R:R:I57	R:R:I61	1.47	No	No	0	4	4
291	R:R:L116	R:R:T120	1.47	No	No	0	6	4
292	R:R:Q324	R:R:T321	1.42	No	No	0	4	7
293	R:R:A305	R:R:F62	1.39	No	No	0	7	4
294	R:R:L215	R:R:L279	1.38	No	No	0	5	6
295	R:R:E193	R:R:I192	1.37	No	No	3	4	1
296	R:R:F32	R:R:S29	1.32	Yes	No	0	2	4
297	R:R:R162	R:R:S160	1.32	No	No	0	5	8
298	R:R:R314	R:R:S255	1.32	No	No	0	7	7
299	R:R:R323	R:R:S319	1.32	No	No	0	4	8
300	R:R:V76	R:R:Y75	1.26	No	No	0	5	3
301	R:R:I148	R:R:R152	1.25	No	No	0	5	5
302	R:R:M237	R:R:R233	1.24	No	No	0	5	5
303	R:R:N77	R:R:R78	1.21	Yes	No	0	6	6
304	R:R:Q154	R:R:R158	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.33182	11	1	0
2	R:R:F32	5.0625	4	3	2
3	R:R:Y34	8.72	5	1	6
4	R:R:K39	6.036	5	1	8
5	R:R:W45	9.0675	4	0	1
6	R:R:M53	3.315	4	0	4
7	R:R:I63	2.3875	4	0	8
8	R:R:N77	6.916	5	4	6
9	R:R:F80	10.32	5	4	8
10	R:R:Y85	7.85	4	0	9
11	R:R:D95	6.428	5	2	9
12	R:R:Y102	8.658	5	0	7
13	R:R:W121	7.03	6	0	9
14	R:R:R124	5.4175	4	0	6
15	R:R:Q125	7.7725	4	1	4
16	R:R:D129	3.932	5	1	5
17	R:R:T133	5.4625	4	1	6
18	R:R:E145	5.935	4	0	8
19	R:R:H147	7.8175	4	5	7
20	R:R:F151	11.6325	4	5	6
21	R:R:H156	8.3175	4	0	4
22	R:R:W172	4.35	4	0	9
23	R:R:W186	6.6725	4	0	6
24	R:R:I189	3.535	4	0	3
25	R:R:M198	6.1775	4	1	3
26	R:R:Y202	6.14	6	1	4
27	R:R:S203	2.8175	4	6	5
28	R:R:Y206	6.5225	4	1	7
29	R:R:F229	6.1225	4	0	6
30	R:R:R248	6.945	4	0	4
31	R:R:M253	3.195	4	0	7
32	R:R:V263	3.375	4	2	8
33	R:R:W271	6.11833	6	1	8
34	R:R:D281	6.635	4	1	4
35	R:R:E293	5.935	4	1	4
36	R:R:N307	5.33	5	2	9
37	R:R:I310	4.09	4	2	8
38	R:R:Y311	4.72143	7	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R124	31.4668	6.95	Yes	Yes	0	0	6
2	R:R:R124	R:R:W121	21.6565	5	Yes	Yes	0	6	9
3	L:L:?1	R:R:Q125	25.896	10.48	Yes	Yes	1	0	4
4	R:R:Q125	R:R:W121	23.0287	7.67	Yes	Yes	0	4	9
5	R:R:L201	R:R:W121	39.8108	13.67	No	Yes	0	1	9
6	R:R:F33	R:R:L201	28.022	9.74	No	No	0	6	1
7	R:R:F32	R:R:F33	18.2444	6.43	Yes	No	0	2	6
8	R:R:L201	R:R:V118	10.0315	4.47	No	No	0	1	2
9	L:L:?1	R:R:W210	94.3964	19.56	Yes	No	1	0	6
10	R:R:T133	R:R:W210	94.3186	7.28	Yes	No	1	6	6
11	R:R:F213	R:R:T133	95.699	5.19	No	Yes	1	5	6
12	R:R:F213	R:R:V136	93.4011	5.24	No	No	1	5	8
13	R:R:V136	R:R:W271	97.3621	3.68	No	Yes	1	8	8
14	R:R:N303	R:R:W271	100	9.04	No	Yes	0	9	8
15	R:R:N303	R:R:N307	96.7722	5.45	No	Yes	0	9	9
16	R:R:D95	R:R:N307	33.0193	6.73	Yes	Yes	2	9	9
17	R:R:D95	R:R:S304	43.8086	8.83	Yes	No	0	9	9
18	R:R:I63	R:R:S304	40.0565	3.1	Yes	No	0	8	9
19	R:R:I63	R:R:V59	33.732	3.07	Yes	No	0	8	7
20	R:R:L298	R:R:V59	31.6266	4.47	No	No	0	6	7
21	R:R:L298	R:R:Y102	29.4884	5.86	No	Yes	0	6	7
22	R:R:C60	R:R:Y102	25.1137	4.03	No	Yes	0	6	7
23	R:R:C60	R:R:F103	23.9995	4.19	No	No	0	6	6
24	R:R:F103	R:R:I57	22.8772	2.51	No	No	0	6	4
25	R:R:I57	R:R:M53	19.4609	4.37	No	Yes	0	4	4
26	R:R:M53	R:R:W45	15.971	4.65	Yes	Yes	0	4	1
27	R:R:L91	R:R:N307	62.1185	5.49	No	Yes	2	9	9
28	R:R:L91	R:R:N138	79.4986	8.24	No	No	0	9	8
29	R:R:N138	R:R:N90	75.8121	13.62	No	No	0	8	9
30	R:R:I168	R:R:N90	69.7292	14.16	No	No	0	8	9
31	R:R:I168	R:R:V164	69.0124	3.07	No	No	0	8	7
32	R:R:E145	R:R:V164	68.2628	4.28	Yes	No	0	8	7
33	R:R:E145	R:R:H156	40.8061	3.69	Yes	Yes	0	8	4
34	R:R:H156	R:R:I84	30.5042	7.95	Yes	No	0	4	8
35	R:R:I84	R:R:Y85	29.4269	3.63	No	Yes	0	8	9
36	R:R:F80	R:R:Y85	25.0809	14.44	Yes	Yes	0	8	9
37	R:R:F80	R:R:N77	12.3664	10.87	Yes	Yes	4	8	6
38	R:R:N307	R:R:Y311	19.2643	3.49	Yes	Yes	2	9	9
39	R:R:N90	R:R:W172	10.0233	7.91	No	Yes	0	9	9
40	R:R:L116	R:R:R124	10.5763	4.86	No	Yes	0	6	6
41	R:R:E145	R:R:R163	34.752	10.47	Yes	No	0	8	6
42	R:R:I148	R:R:R163	33.7238	7.52	No	No	0	5	6
43	R:R:I144	R:R:I148	31.6143	2.94	No	No	0	6	5
44	R:R:I144	R:R:L224	30.5452	2.85	No	No	0	6	6
45	R:R:H147	R:R:L224	29.4679	6.43	Yes	No	0	7	6
46	R:R:H147	R:R:I228	18.2935	3.98	Yes	No	0	7	9
47	L:L:?1	R:R:D129	21.5869	4.86	Yes	Yes	1	0	5
48	R:R:D129	R:R:Y206	15.5737	4.6	Yes	Yes	1	5	7
49	R:R:W186	R:R:Y206	13.9352	5.79	Yes	Yes	0	6	7
50	L:L:?1	R:R:M198	13.3535	5.06	Yes	Yes	1	0	3
51	R:R:F267	R:R:W271	17.9986	11.02	No	Yes	1	9	8
52	R:R:F218	R:R:F267	17.1425	12.86	No	No	0	5	9
53	R:R:F218	R:R:I268	11.203	6.28	No	No	0	5	6
54	R:R:I228	R:R:V232	17.1343	1.54	No	No	0	9	7
55	R:R:M253	R:R:V232	15.9505	3.04	Yes	No	0	7	7
56	R:R:D95	R:R:L91	17.9617	5.43	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K39	5.04	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T109	9.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:T113	4.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	6.95	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	10.48	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	4.86	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M198	5.06	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:W210	19.56	1	Yes	No	0	6	0	1
L:L:?1	R:R:L278	4.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	7.59	1	Yes	Yes	0	4	0	1
R:R:K39	R:R:Y34	10.75	1	Yes	Yes	8	6	1	2
R:R:T113	R:R:Y34	3.75	0	No	Yes	5	6	1	2
R:R:W121	R:R:Y34	7.72	0	Yes	Yes	9	6	2	2
R:R:P200	R:R:Y34	16.69	1	No	Yes	6	6	2	2
R:R:K39	R:R:P200	3.35	1	Yes	No	8	6	1	2
R:R:K39	R:R:L290	5.64	1	Yes	No	8	3	1	2
R:R:E293	R:R:K39	5.4	1	Yes	Yes	4	8	1	1
R:R:L105	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:R124	R:R:W121	5	0	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	7.67	1	Yes	Yes	4	9	1	2
R:R:D129	R:R:Q125	3.92	1	Yes	Yes	5	4	1	1
R:R:Q125	R:R:Y202	9.02	1	Yes	Yes	4	4	1	2
R:R:D129	R:R:Y202	4.6	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	4.6	1	Yes	Yes	5	7	1	2
R:R:M178	R:R:T133	6.02	1	No	Yes	5	6	2	2
R:R:T133	R:R:W210	7.28	1	Yes	No	6	6	2	1
R:R:M178	R:R:W210	3.49	1	No	No	5	6	2	1
R:R:D281	R:R:M198	8.32	1	Yes	Yes	4	3	2	1
R:R:M198	R:R:V289	4.56	1	Yes	No	3	4	1	2
R:R:E293	R:R:M198	6.77	1	Yes	Yes	4	3	1	1
R:R:Y202	R:R:Y206	5.96	1	Yes	Yes	4	7	2	2
R:R:D281	R:R:V289	4.38	1	Yes	No	4	4	2	2
R:R:E293	R:R:L290	3.98	1	Yes	No	4	3	1	2
L:L:?1	R:R:G274	2.45	1	Yes	No	0	5	0	1
R:R:D129	R:R:G126	1.68	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	280
Number of Links	304
Number of Hubs	38
Number of Links mediated by Hubs	147
Number of Communities	6
Number of Nodes involved in Communities	51
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	46162
Length Of Smallest Path	3
Average Path Length	16.0595
Length of Longest Path	33
Minimum Path Strength	1.505
Average Path Strength	6.59803
Maximum Path Strength	20.955
Minimum Path Correlation	0.7
Average Path Correlation	0.936116
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	53.042
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.042
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • protein binding • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • regulation of metabolic process • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • protein-containing complex localization • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • glutamatergic synapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • dendritic shaft • plasma membrane bounded cell projection • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • hydrolase activity • GDP binding • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • anchoring junction • focal adhesion • cell-substrate junction • pigment granule • melanosome • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • brush border • cell projection membrane • nucleus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9IZH_nogp_Chain_R S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R H S S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Q I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	10.1016/j.jsb.2024.108164
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	10.1038/s41467-022-33121-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	10.1038/s41467-022-28417-2
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	10.1016/j.cell.2015.06.002

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