psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K39	5.04	Yes	Yes	1	0	8
2	L:L:?1	R:R:T109	9.49	Yes	No	0	0	5
3	L:L:?1	R:R:T113	4.22	Yes	No	0	0	5
4	L:L:?1	R:R:R124	6.95	Yes	Yes	0	0	6
5	L:L:?1	R:R:Q125	10.48	Yes	Yes	1	0	4
6	L:L:?1	R:R:D129	4.86	Yes	Yes	1	0	5
7	L:L:?1	R:R:M198	5.06	Yes	Yes	1	0	3
8	L:L:?1	R:R:W210	19.56	Yes	No	1	0	6
9	L:L:?1	R:R:L278	4.95	Yes	No	0	0	6
10	L:L:?1	R:R:E293	7.59	Yes	Yes	1	0	4
11	R:R:I30	R:R:W121	4.7	No	Yes	0	6	9
12	R:R:F32	R:R:F33	6.43	Yes	No	0	2	6
13	R:R:F32	R:R:R36	7.48	Yes	No	3	2	3
14	R:R:F32	R:R:I192	5.02	Yes	No	3	2	1
15	R:R:F33	R:R:I189	3.77	No	Yes	0	6	3
16	R:R:F33	R:R:L201	9.74	No	No	0	6	1
17	R:R:K39	R:R:Y34	10.75	Yes	Yes	1	8	6
18	R:R:L41	R:R:Y34	4.69	No	Yes	0	2	6
19	R:R:T113	R:R:Y34	3.75	No	Yes	0	5	6
20	R:R:W121	R:R:Y34	7.72	Yes	Yes	0	9	6
21	R:R:P200	R:R:Y34	16.69	No	Yes	1	6	6
22	R:R:I192	R:R:R36	7.52	No	No	3	1	3
23	R:R:P200	R:R:S37	7.13	No	No	0	6	7
24	R:R:K39	R:R:P200	3.35	Yes	No	1	8	6
25	R:R:K39	R:R:L290	5.64	Yes	No	1	8	3
26	R:R:E293	R:R:K39	5.4	Yes	Yes	1	4	8
27	R:R:L41	R:R:R114	3.64	No	No	0	2	6
28	R:R:E44	R:R:T43	4.23	No	No	0	1	3
29	R:R:K50	R:R:W45	3.48	No	Yes	0	3	1
30	R:R:M53	R:R:W45	4.65	Yes	Yes	0	4	1
31	R:R:P111	R:R:W45	25.67	No	Yes	0	4	1
32	R:R:K294	R:R:V52	4.55	No	No	0	4	5
33	R:R:F295	R:R:V52	3.93	No	No	0	4	5
34	R:R:I57	R:R:M53	4.37	No	Yes	0	4	4
35	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
36	R:R:L298	R:R:V59	4.47	No	No	0	6	7
37	R:R:C60	R:R:Y102	4.03	No	Yes	0	6	7
38	R:R:C60	R:R:F103	4.19	No	No	0	6	6
39	R:R:A66	R:R:F62	5.55	No	No	0	8	4
40	R:R:I63	R:R:S304	3.1	Yes	No	0	8	9
41	R:R:F96	R:R:M64	6.22	No	No	0	7	6
42	R:R:A92	R:R:N67	3.13	No	No	0	9	9
43	R:R:D95	R:R:N67	6.73	Yes	No	0	9	9
44	R:R:N67	R:R:P308	9.77	No	No	0	9	9
45	R:R:F322	R:R:L69	9.74	No	No	0	6	7
46	R:R:S312	R:R:V70	3.23	No	No	0	7	9
47	R:R:V72	R:R:V76	3.21	No	No	0	5	5
48	R:R:I325	R:R:V72	3.07	No	No	0	6	5
49	R:R:A73	R:R:T321	3.36	No	No	0	7	7
50	R:R:N77	R:R:R79	4.82	Yes	No	4	6	6
51	R:R:F80	R:R:N77	10.87	Yes	Yes	4	8	6
52	R:R:E317	R:R:N77	11.83	No	Yes	4	7	6
53	R:R:N77	R:R:T321	5.85	Yes	No	0	6	7
54	R:R:E317	R:R:R79	25.59	No	No	4	7	6
55	R:R:F80	R:R:Y85	14.44	Yes	Yes	0	8	9
56	R:R:E317	R:R:F80	16.32	No	Yes	4	7	8
57	R:R:F80	R:R:M318	7.46	Yes	No	0	8	8
58	R:R:H81	R:R:Y86	3.27	No	No	0	8	4
59	R:R:F82	R:R:Y85	4.13	No	Yes	0	7	9
60	R:R:F82	R:R:T157	7.78	No	No	0	7	4
61	R:R:H156	R:R:P83	10.68	Yes	No	0	4	6
62	R:R:N161	R:R:P83	3.26	No	No	0	3	6
63	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
64	R:R:H156	R:R:I84	7.95	Yes	No	0	4	8
65	R:R:D315	R:R:Y85	9.2	No	Yes	0	8	9
66	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
67	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
68	R:R:M88	R:R:Y311	5.99	No	Yes	0	8	9
69	R:R:N138	R:R:N90	13.62	No	No	0	8	9
70	R:R:I168	R:R:N90	14.16	No	No	0	8	9
71	R:R:N90	R:R:W172	7.91	No	Yes	0	9	9
72	R:R:D95	R:R:L91	5.43	Yes	No	2	9	9
73	R:R:L91	R:R:N138	8.24	No	No	0	9	8
74	R:R:L91	R:R:N307	5.49	No	Yes	2	9	9
75	R:R:D95	R:R:S135	4.42	Yes	No	0	9	9
76	R:R:D95	R:R:S304	8.83	Yes	No	0	9	9
77	R:R:D95	R:R:N307	6.73	Yes	Yes	2	9	9
78	R:R:F96	R:R:L100	6.09	No	No	0	7	4
79	R:R:A98	R:R:S131	3.42	No	No	0	8	6
80	R:R:A98	R:R:S304	3.42	No	No	0	8	9
81	R:R:A101	R:R:S131	3.42	No	No	0	5	6
82	R:R:M106	R:R:Y102	9.58	No	Yes	0	6	7
83	R:R:L297	R:R:Y102	5.86	No	Yes	0	6	7
84	R:R:L298	R:R:Y102	5.86	No	Yes	0	6	7
85	R:R:E301	R:R:Y102	17.96	No	Yes	0	7	7
86	R:R:N108	R:R:Y104	8.14	No	No	0	5	5
87	R:R:L105	R:R:R124	4.86	No	Yes	0	6	6
88	R:R:N108	R:R:N112	4.09	No	No	0	5	4
89	R:R:L116	R:R:N108	5.49	No	No	0	6	5
90	R:R:G110	R:R:P111	4.06	No	No	0	5	4
91	R:R:N112	R:R:R115	14.46	No	No	0	4	3
92	R:R:L116	R:R:R124	4.86	No	Yes	0	6	6
93	R:R:T117	R:R:T120	4.71	No	No	0	6	4
94	R:R:I189	R:R:V118	3.07	Yes	No	0	3	2
95	R:R:L201	R:R:V118	4.47	No	No	0	1	2
96	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
97	R:R:R124	R:R:W121	5	Yes	Yes	0	6	9
98	R:R:Q125	R:R:W121	7.67	Yes	Yes	0	4	9
99	R:R:L201	R:R:W121	13.67	No	Yes	0	1	9
100	R:R:L122	R:R:Y202	3.52	No	Yes	0	5	4
101	R:R:D129	R:R:Q125	3.92	Yes	Yes	1	5	4
102	R:R:Q125	R:R:Y202	9.02	Yes	Yes	1	4	4
103	R:R:D129	R:R:Y202	4.6	Yes	Yes	1	5	4
104	R:R:D129	R:R:Y206	4.6	Yes	Yes	1	5	7
105	R:R:L132	R:R:W271	5.69	No	Yes	0	7	8
106	R:R:A175	R:R:T133	3.36	No	Yes	0	8	6
107	R:R:M178	R:R:T133	6.02	No	Yes	1	5	6
108	R:R:T133	R:R:W210	7.28	Yes	No	1	6	6
109	R:R:F213	R:R:T133	5.19	No	Yes	1	5	6
110	R:R:A134	R:R:W172	3.89	No	Yes	0	7	9
111	R:R:F213	R:R:V136	5.24	No	No	1	5	8
112	R:R:T217	R:R:V136	4.76	No	No	1	7	8
113	R:R:V136	R:R:W271	3.68	No	Yes	1	8	8
114	R:R:A137	R:R:I171	3.25	No	No	0	5	7
115	R:R:I171	R:R:N138	7.08	No	No	0	7	8
116	R:R:L139	R:R:N307	5.49	No	Yes	2	8	9
117	R:R:L139	R:R:Y311	3.52	No	Yes	2	8	9
118	R:R:L140	R:R:T217	7.37	No	No	0	7	7
119	R:R:I142	R:R:R146	5.01	No	No	2	8	9
120	R:R:I142	R:R:Y311	3.63	No	Yes	2	8	9
121	R:R:A143	R:R:Y225	5.34	No	No	0	8	9
122	R:R:E145	R:R:H156	3.69	Yes	Yes	0	8	4
123	R:R:E145	R:R:R163	10.47	Yes	No	0	8	6
124	R:R:E145	R:R:V164	4.28	Yes	No	0	8	7
125	R:R:R146	R:R:Y225	9.26	No	No	0	9	9
126	R:R:R146	R:R:Y311	4.12	No	Yes	2	9	9
127	R:R:F151	R:R:H147	11.31	Yes	Yes	5	6	7
128	R:R:H147	R:R:L224	6.43	Yes	No	0	7	6
129	R:R:H147	R:R:H227	9.55	Yes	No	5	7	5
130	R:R:H147	R:R:I228	3.98	Yes	No	0	7	9
131	R:R:I148	R:R:R163	7.52	No	No	0	5	6
132	R:R:H156	R:R:T149	10.95	Yes	No	0	4	8
133	R:R:M159	R:R:T149	4.52	No	No	0	6	8
134	R:R:F151	R:R:V150	5.24	Yes	No	0	6	8
135	R:R:F151	R:R:H227	12.44	Yes	No	5	6	5
136	R:R:F151	R:R:Y231	17.54	Yes	No	0	6	6
137	R:R:M159	R:R:Q154	9.52	No	No	0	6	4
138	R:R:L155	R:R:R158	6.07	No	No	0	8	3
139	R:R:I168	R:R:V164	3.07	No	No	0	8	7
140	R:R:I171	R:R:V167	3.07	No	No	0	7	6
141	R:R:M178	R:R:W210	3.49	No	No	1	5	6
142	R:R:I181	R:R:P182	3.39	No	No	0	5	6
143	R:R:I181	R:R:W186	4.7	No	Yes	0	5	6
144	R:R:P182	R:R:Y202	9.74	No	Yes	1	6	4
145	R:R:P182	R:R:Y206	9.74	No	Yes	1	6	7
146	R:R:S205	R:R:W186	6.18	No	Yes	0	5	6
147	R:R:W186	R:R:Y206	5.79	Yes	Yes	0	6	7
148	R:R:F209	R:R:W186	10.02	No	Yes	0	6	6
149	R:R:I189	R:R:N187	5.66	Yes	No	0	3	6
150	R:R:C188	R:R:C195	7.28	No	No	6	5	9
151	R:R:D191	R:R:E193	5.2	No	No	3	4	4
152	R:R:D191	R:R:N194	12.12	No	No	3	4	3
153	R:R:E193	R:R:N194	3.94	No	No	3	4	3
154	R:R:L207	R:R:S196	6.01	No	No	0	6	5
155	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
156	R:R:D281	R:R:N197	9.42	Yes	No	0	4	5
157	R:R:D281	R:R:M198	8.32	Yes	Yes	1	4	3
158	R:R:M198	R:R:V289	4.56	Yes	No	1	3	4
159	R:R:E293	R:R:M198	6.77	Yes	Yes	1	4	3
160	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
161	R:R:Y202	R:R:Y206	5.96	Yes	Yes	1	4	7
162	R:R:S203	R:R:S205	4.89	Yes	No	0	5	5
163	R:R:V208	R:R:V282	4.81	No	No	0	4	5
164	R:R:A211	R:R:L279	3.15	No	No	0	4	6
165	R:R:F213	R:R:T217	3.89	No	No	1	5	7
166	R:R:F267	R:R:N214	7.25	No	No	1	9	7
167	R:R:N214	R:R:W271	3.39	No	Yes	1	7	8
168	R:R:L275	R:R:N214	6.87	No	No	0	6	7
169	R:R:L215	R:R:L275	5.54	No	No	0	5	6
170	R:R:F218	R:R:V222	7.87	No	No	0	5	4
171	R:R:F218	R:R:F267	12.86	No	No	0	5	9
172	R:R:F218	R:R:I268	6.28	No	No	0	5	6
173	R:R:L264	R:R:V222	4.47	No	No	0	7	4
174	R:R:V263	R:R:Y225	3.79	Yes	No	0	8	9
175	R:R:F229	R:R:R233	3.21	Yes	No	0	6	5
176	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
177	R:R:F229	R:R:L257	12.18	Yes	No	0	6	7
178	R:R:M253	R:R:R233	3.72	Yes	No	0	7	5
179	R:R:Q234	R:R:R235	5.84	No	No	0	4	7
180	R:R:R235	R:R:R238	4.26	No	No	0	7	5
181	R:R:R248	R:R:T236	7.76	Yes	No	0	4	5
182	R:R:M239	R:R:R248	4.96	No	Yes	0	7	4
183	R:R:H242	R:R:R241	18.05	No	No	0	4	4
184	R:R:R248	R:R:S243	11.86	Yes	No	0	4	3
185	R:R:G245	R:R:P246	4.06	No	No	0	1	4
186	R:R:R247	R:R:R248	3.2	No	Yes	0	3	4
187	R:R:M254	R:R:R250	3.72	No	No	0	5	4
188	R:R:R314	R:R:T259	11.64	No	No	0	7	8
189	R:R:I262	R:R:I310	4.42	No	Yes	0	6	8
190	R:R:I310	R:R:V263	3.07	Yes	Yes	2	8	8
191	R:R:V263	R:R:Y311	5.05	Yes	Yes	2	8	9
192	R:R:F267	R:R:W271	11.02	No	Yes	1	9	8
193	R:R:I268	R:R:T272	6.08	No	No	0	6	5
194	R:R:C270	R:R:N303	7.87	No	No	0	9	9
195	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
196	R:R:N303	R:R:W271	9.04	No	Yes	0	9	8
197	R:R:P273	R:R:T272	5.25	No	No	0	9	5
198	R:R:F296	R:R:P273	8.67	No	No	0	5	9
199	R:R:F296	R:R:L277	8.53	No	No	0	5	4
200	R:R:D281	R:R:V289	4.38	Yes	No	1	4	4
201	R:R:C284	R:R:C287	7.28	No	No	1	4	5
202	R:R:E293	R:R:L290	3.98	Yes	No	1	4	3
203	R:R:F296	R:R:Y292	6.19	No	No	0	5	3
204	R:R:F302	R:R:M306	4.98	No	No	0	5	6
205	R:R:N303	R:R:N307	5.45	No	Yes	0	9	9
206	R:R:N307	R:R:Y311	3.49	Yes	Yes	2	9	9
207	R:R:I310	R:R:Y311	7.25	Yes	Yes	2	8	9
208	R:R:M318	R:R:S312	4.6	No	No	0	8	7
209	R:R:R314	R:R:Y313	12.35	No	No	0	7	5
210	R:R:A320	R:R:K316	3.21	No	No	0	4	5
211	R:R:F322	R:R:M318	6.22	No	No	0	6	8
212	R:R:K316	R:R:S319	3.06	No	No	0	5	8
213	R:R:I176	R:R:T130	3.04	No	No	0	3	6
214	R:R:M253	R:R:V232	3.04	Yes	No	0	7	7
215	R:R:F97	R:R:W172	3.01	No	Yes	0	7	9
216	R:R:F229	R:R:G230	3.01	Yes	No	0	6	2
217	R:R:M253	R:R:T236	3.01	Yes	No	0	7	5
218	R:R:M253	R:R:T252	3.01	Yes	No	0	7	5
219	R:R:N46	R:R:S49	2.98	No	No	0	2	1
220	R:R:L140	R:R:V220	2.98	No	No	0	7	5
221	R:R:L264	R:R:V260	2.98	No	No	0	7	8
222	R:R:L280	R:R:V276	2.98	No	No	0	5	6
223	R:R:I144	R:R:I148	2.94	No	No	0	6	5
224	R:R:D204	R:R:S203	2.94	No	Yes	0	4	5
225	R:R:N46	R:R:T47	2.92	No	No	0	2	5
226	R:R:D204	R:R:V282	2.92	No	No	0	4	5
227	R:R:I61	R:R:L65	2.85	No	No	0	4	4
228	R:R:I128	R:R:L105	2.85	No	No	0	6	6
229	R:R:I144	R:R:L224	2.85	No	No	0	6	6
230	R:R:L68	R:R:M71	2.83	No	No	0	4	7
231	R:R:L264	R:R:M221	2.83	No	No	0	7	9
232	R:R:L298	R:R:L55	2.77	No	No	0	6	4
233	R:R:L326	R:R:L69	2.77	No	No	0	6	7
234	R:R:A305	R:R:F302	2.77	No	No	0	7	5
235	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
236	R:R:R114	R:R:T43	2.59	No	No	0	6	3
237	R:R:A94	R:R:W172	2.59	No	Yes	0	8	9
238	R:R:F97	R:R:T130	2.59	No	No	0	7	6
239	R:R:F103	R:R:I57	2.51	No	No	0	6	4
240	R:R:F62	R:R:I309	2.51	No	No	0	4	7
241	R:R:F80	R:R:I74	2.51	Yes	No	0	8	7
242	R:R:F107	R:R:M53	2.49	No	Yes	0	5	4
243	R:R:S49	R:R:W45	2.47	No	Yes	0	1	1
244	L:L:?1	R:R:G274	2.45	Yes	No	0	0	5
245	R:R:F295	R:R:L51	2.44	No	No	0	4	4
246	R:R:F97	R:R:L127	2.44	No	No	0	7	5
247	R:R:L123	R:R:Y104	2.34	No	No	0	4	5
248	R:R:R238	R:R:R241	2.13	No	No	0	5	4
249	R:R:R235	R:R:Y231	2.06	No	No	0	7	6
250	R:R:A42	R:R:G110	1.95	No	No	0	4	5
251	R:R:C284	R:R:P285	1.88	No	No	0	4	3
252	R:R:G56	R:R:V59	1.84	No	No	0	6	7
253	R:R:G179	R:R:T130	1.82	No	No	0	7	6
254	R:R:G99	R:R:I63	1.76	No	Yes	0	7	8
255	R:R:G54	R:R:M53	1.75	No	Yes	0	4	4
256	R:R:G99	R:R:M64	1.75	No	No	0	7	6
257	R:R:C188	R:R:S203	1.72	No	Yes	6	5	5
258	R:R:C195	R:R:S203	1.72	No	Yes	6	9	5
259	R:R:A31	R:R:S29	1.71	No	No	0	2	4
260	R:R:A180	R:R:S183	1.71	No	No	0	4	6
261	R:R:C287	R:R:V289	1.71	No	No	1	5	4
262	R:R:A141	R:R:V167	1.7	No	No	0	8	6
263	R:R:G185	R:R:N187	1.7	No	No	0	5	6
264	R:R:D129	R:R:G126	1.68	Yes	No	0	5	6
265	R:R:C190	R:R:I189	1.64	No	Yes	0	3	3
266	R:R:C270	R:R:I269	1.64	No	No	0	9	5
267	R:R:L299	R:R:P273	1.64	No	No	0	7	9
268	R:R:A305	R:R:I63	1.62	No	Yes	0	7	8
269	R:R:A73	R:R:I325	1.62	No	No	0	7	6
270	R:R:A89	R:R:I74	1.62	No	No	0	7	7
271	R:R:S183	R:R:V184	1.62	No	No	0	6	5
272	R:R:A266	R:R:I310	1.62	No	Yes	0	6	8
273	R:R:C270	R:R:M306	1.62	No	No	0	9	6
274	R:R:A92	R:R:M71	1.61	No	No	0	9	7
275	R:R:A93	R:R:M71	1.61	No	No	0	6	7
276	R:R:A137	R:R:M174	1.61	No	No	0	5	4
277	R:R:V48	R:R:V52	1.6	No	No	0	3	5
278	R:R:S119	R:R:T117	1.6	No	No	0	1	6
279	R:R:V169	R:R:V170	1.6	No	No	0	4	3
280	R:R:V216	R:R:V220	1.6	No	No	0	4	5
281	R:R:T259	R:R:V263	1.59	No	Yes	0	8	8
282	R:R:C284	R:R:L280	1.59	No	No	1	4	5
283	R:R:C287	R:R:L280	1.59	No	No	1	5	5
284	R:R:A31	R:R:N35	1.56	No	No	0	2	7
285	R:R:I181	R:R:V177	1.54	No	No	0	5	4
286	R:R:I212	R:R:V216	1.54	No	No	0	4	4
287	R:R:I228	R:R:V232	1.54	No	No	0	9	7
288	R:R:A291	R:R:D288	1.54	No	No	0	2	1
289	R:R:K294	R:R:S49	1.53	No	No	0	4	1
290	R:R:I57	R:R:I61	1.47	No	No	0	4	4
291	R:R:L116	R:R:T120	1.47	No	No	0	6	4
292	R:R:Q324	R:R:T321	1.42	No	No	0	4	7
293	R:R:A305	R:R:F62	1.39	No	No	0	7	4
294	R:R:L215	R:R:L279	1.38	No	No	0	5	6
295	R:R:E193	R:R:I192	1.37	No	No	3	4	1
296	R:R:F32	R:R:S29	1.32	Yes	No	0	2	4
297	R:R:R162	R:R:S160	1.32	No	No	0	5	8
298	R:R:R314	R:R:S255	1.32	No	No	0	7	7
299	R:R:R323	R:R:S319	1.32	No	No	0	4	8
300	R:R:V76	R:R:Y75	1.26	No	No	0	5	3
301	R:R:I148	R:R:R152	1.25	No	No	0	5	5
302	R:R:M237	R:R:R233	1.24	No	No	0	5	5
303	R:R:N77	R:R:R78	1.21	Yes	No	0	6	6
304	R:R:Q154	R:R:R158	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.33182	11	1	0
2	R:R:F32	5.0625	4	3	2
3	R:R:Y34	8.72	5	1	6
4	R:R:K39	6.036	5	1	8
5	R:R:W45	9.0675	4	0	1
6	R:R:M53	3.315	4	0	4
7	R:R:I63	2.3875	4	0	8
8	R:R:N77	6.916	5	4	6
9	R:R:F80	10.32	5	4	8
10	R:R:Y85	7.85	4	0	9
11	R:R:D95	6.428	5	2	9
12	R:R:Y102	8.658	5	0	7
13	R:R:W121	7.03	6	0	9
14	R:R:R124	5.4175	4	0	6
15	R:R:Q125	7.7725	4	1	4
16	R:R:D129	3.932	5	1	5
17	R:R:T133	5.4625	4	1	6
18	R:R:E145	5.935	4	0	8
19	R:R:H147	7.8175	4	5	7
20	R:R:F151	11.6325	4	5	6
21	R:R:H156	8.3175	4	0	4
22	R:R:W172	4.35	4	0	9
23	R:R:W186	6.6725	4	0	6
24	R:R:I189	3.535	4	0	3
25	R:R:M198	6.1775	4	1	3
26	R:R:Y202	6.14	6	1	4
27	R:R:S203	2.8175	4	6	5
28	R:R:Y206	6.5225	4	1	7
29	R:R:F229	6.1225	4	0	6
30	R:R:R248	6.945	4	0	4
31	R:R:M253	3.195	4	0	7
32	R:R:V263	3.375	4	2	8
33	R:R:W271	6.11833	6	1	8
34	R:R:D281	6.635	4	1	4
35	R:R:E293	5.935	4	1	4
36	R:R:N307	5.33	5	2	9
37	R:R:I310	4.09	4	2	8
38	R:R:Y311	4.72143	7	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R124	31.4668	6.95	Yes	Yes	0	0	6
2	R:R:R124	R:R:W121	21.6565	5	Yes	Yes	0	6	9
3	L:L:?1	R:R:Q125	25.896	10.48	Yes	Yes	1	0	4
4	R:R:Q125	R:R:W121	23.0287	7.67	Yes	Yes	0	4	9
5	R:R:L201	R:R:W121	39.8108	13.67	No	Yes	0	1	9
6	R:R:F33	R:R:L201	28.022	9.74	No	No	0	6	1
7	R:R:F32	R:R:F33	18.2444	6.43	Yes	No	0	2	6
8	R:R:L201	R:R:V118	10.0315	4.47	No	No	0	1	2
9	L:L:?1	R:R:W210	94.3964	19.56	Yes	No	1	0	6
10	R:R:T133	R:R:W210	94.3186	7.28	Yes	No	1	6	6
11	R:R:F213	R:R:T133	95.699	5.19	No	Yes	1	5	6
12	R:R:F213	R:R:V136	93.4011	5.24	No	No	1	5	8
13	R:R:V136	R:R:W271	97.3621	3.68	No	Yes	1	8	8
14	R:R:N303	R:R:W271	100	9.04	No	Yes	0	9	8
15	R:R:N303	R:R:N307	96.7722	5.45	No	Yes	0	9	9
16	R:R:D95	R:R:N307	33.0193	6.73	Yes	Yes	2	9	9
17	R:R:D95	R:R:S304	43.8086	8.83	Yes	No	0	9	9
18	R:R:I63	R:R:S304	40.0565	3.1	Yes	No	0	8	9
19	R:R:I63	R:R:V59	33.732	3.07	Yes	No	0	8	7
20	R:R:L298	R:R:V59	31.6266	4.47	No	No	0	6	7
21	R:R:L298	R:R:Y102	29.4884	5.86	No	Yes	0	6	7
22	R:R:C60	R:R:Y102	25.1137	4.03	No	Yes	0	6	7
23	R:R:C60	R:R:F103	23.9995	4.19	No	No	0	6	6
24	R:R:F103	R:R:I57	22.8772	2.51	No	No	0	6	4
25	R:R:I57	R:R:M53	19.4609	4.37	No	Yes	0	4	4
26	R:R:M53	R:R:W45	15.971	4.65	Yes	Yes	0	4	1
27	R:R:L91	R:R:N307	62.1185	5.49	No	Yes	2	9	9
28	R:R:L91	R:R:N138	79.4986	8.24	No	No	0	9	8
29	R:R:N138	R:R:N90	75.8121	13.62	No	No	0	8	9
30	R:R:I168	R:R:N90	69.7292	14.16	No	No	0	8	9
31	R:R:I168	R:R:V164	69.0124	3.07	No	No	0	8	7
32	R:R:E145	R:R:V164	68.2628	4.28	Yes	No	0	8	7
33	R:R:E145	R:R:H156	40.8061	3.69	Yes	Yes	0	8	4
34	R:R:H156	R:R:I84	30.5042	7.95	Yes	No	0	4	8
35	R:R:I84	R:R:Y85	29.4269	3.63	No	Yes	0	8	9
36	R:R:F80	R:R:Y85	25.0809	14.44	Yes	Yes	0	8	9
37	R:R:F80	R:R:N77	12.3664	10.87	Yes	Yes	4	8	6
38	R:R:N307	R:R:Y311	19.2643	3.49	Yes	Yes	2	9	9
39	R:R:N90	R:R:W172	10.0233	7.91	No	Yes	0	9	9
40	R:R:L116	R:R:R124	10.5763	4.86	No	Yes	0	6	6
41	R:R:E145	R:R:R163	34.752	10.47	Yes	No	0	8	6
42	R:R:I148	R:R:R163	33.7238	7.52	No	No	0	5	6
43	R:R:I144	R:R:I148	31.6143	2.94	No	No	0	6	5
44	R:R:I144	R:R:L224	30.5452	2.85	No	No	0	6	6
45	R:R:H147	R:R:L224	29.4679	6.43	Yes	No	0	7	6
46	R:R:H147	R:R:I228	18.2935	3.98	Yes	No	0	7	9
47	L:L:?1	R:R:D129	21.5869	4.86	Yes	Yes	1	0	5
48	R:R:D129	R:R:Y206	15.5737	4.6	Yes	Yes	1	5	7
49	R:R:W186	R:R:Y206	13.9352	5.79	Yes	Yes	0	6	7
50	L:L:?1	R:R:M198	13.3494	5.06	Yes	Yes	1	0	3
51	R:R:F267	R:R:W271	17.9986	11.02	No	Yes	1	9	8
52	R:R:F218	R:R:F267	17.1425	12.86	No	No	0	5	9
53	R:R:F218	R:R:I268	11.203	6.28	No	No	0	5	6
54	R:R:I228	R:R:V232	17.1343	1.54	No	No	0	9	7
55	R:R:M253	R:R:V232	15.9505	3.04	Yes	No	0	7	7
56	R:R:D95	R:R:L91	17.9617	5.43	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K39	5.04	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T109	9.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:T113	4.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	6.95	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	10.48	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	4.86	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M198	5.06	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:W210	19.56	1	Yes	No	0	6	0	1
L:L:?1	R:R:L278	4.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	7.59	1	Yes	Yes	0	4	0	1
R:R:K39	R:R:Y34	10.75	1	Yes	Yes	8	6	1	2
R:R:T113	R:R:Y34	3.75	0	No	Yes	5	6	1	2
R:R:W121	R:R:Y34	7.72	0	Yes	Yes	9	6	2	2
R:R:P200	R:R:Y34	16.69	1	No	Yes	6	6	2	2
R:R:K39	R:R:P200	3.35	1	Yes	No	8	6	1	2
R:R:K39	R:R:L290	5.64	1	Yes	No	8	3	1	2
R:R:E293	R:R:K39	5.4	1	Yes	Yes	4	8	1	1
R:R:L105	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:R124	R:R:W121	5	0	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	7.67	1	Yes	Yes	4	9	1	2
R:R:D129	R:R:Q125	3.92	1	Yes	Yes	5	4	1	1
R:R:Q125	R:R:Y202	9.02	1	Yes	Yes	4	4	1	2
R:R:D129	R:R:Y202	4.6	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	4.6	1	Yes	Yes	5	7	1	2
R:R:M178	R:R:T133	6.02	1	No	Yes	5	6	2	2
R:R:T133	R:R:W210	7.28	1	Yes	No	6	6	2	1
R:R:M178	R:R:W210	3.49	1	No	No	5	6	2	1
R:R:D281	R:R:M198	8.32	1	Yes	Yes	4	3	2	1
R:R:M198	R:R:V289	4.56	1	Yes	No	3	4	1	2
R:R:E293	R:R:M198	6.77	1	Yes	Yes	4	3	1	1
R:R:Y202	R:R:Y206	5.96	1	Yes	Yes	4	7	2	2
R:R:D281	R:R:V289	4.38	1	Yes	No	4	4	2	2
R:R:E293	R:R:L290	3.98	1	Yes	No	4	3	1	2
L:L:?1	R:R:G274	2.45	1	Yes	No	0	5	0	1
R:R:D129	R:R:G126	1.68	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	280
Number of Links	304
Number of Hubs	38
Number of Links mediated by Hubs	147
Number of Communities	6
Number of Nodes involved in Communities	51
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	46160
Length Of Smallest Path	3
Average Path Length	16.06
Length of Longest Path	33
Minimum Path Strength	1.505
Average Path Strength	6.59811
Maximum Path Strength	20.955
Minimum Path Correlation	0.7
Average Path Correlation	0.936158
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	53.0038
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.0404
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9IZH_nogp_Chain_R S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R H S S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Q I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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