psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	4.19	Yes	Yes	1	0	6
2	L:L:?1	R:R:K39	8.07	Yes	Yes	1	0	8
3	L:L:?1	R:R:L105	4.95	Yes	No	1	0	6
4	L:L:?1	R:R:T109	8.44	Yes	No	0	0	5
5	L:L:?1	R:R:T113	6.33	Yes	No	1	0	5
6	L:L:?1	R:R:R124	6.95	Yes	Yes	1	0	6
7	L:L:?1	R:R:Q125	7.62	Yes	Yes	1	0	4
8	L:L:?1	R:R:D129	9.71	Yes	Yes	1	0	5
9	L:L:?1	R:R:Y202	3.36	Yes	Yes	1	0	4
10	L:L:?1	R:R:W210	23.63	Yes	Yes	1	0	6
11	L:L:?1	R:R:L278	5.94	Yes	No	0	0	6
12	L:L:?1	R:R:E293	5.69	Yes	Yes	1	0	4
13	L:L:?1	R:R:K294	7.06	Yes	No	0	0	4
14	L:L:?1	R:R:L297	6.93	Yes	No	0	0	6
15	R:R:I30	R:R:Y34	3.63	No	Yes	1	6	6
16	R:R:I30	R:R:W121	5.87	No	Yes	1	6	9
17	R:R:F32	R:R:F33	10.72	No	No	0	2	6
18	R:R:F32	R:R:R36	11.76	No	No	0	2	3
19	R:R:F33	R:R:I189	5.02	No	No	1	6	3
20	R:R:F33	R:R:L201	14.61	No	Yes	1	6	1
21	R:R:K39	R:R:Y34	11.94	Yes	Yes	1	8	6
22	R:R:L41	R:R:Y34	4.69	No	Yes	0	2	6
23	R:R:W121	R:R:Y34	9.65	Yes	Yes	1	9	6
24	R:R:P200	R:R:Y34	18.08	No	Yes	1	6	6
25	R:R:I192	R:R:R36	8.77	No	No	0	1	3
26	R:R:P200	R:R:S37	7.13	No	No	0	6	7
27	R:R:K39	R:R:P200	3.35	Yes	No	1	8	6
28	R:R:K39	R:R:L290	4.23	Yes	No	1	8	3
29	R:R:E293	R:R:K39	10.8	Yes	Yes	1	4	8
30	R:R:L41	R:R:R114	4.86	No	No	0	2	6
31	R:R:R114	R:R:T43	3.88	No	No	0	6	3
32	R:R:M53	R:R:W45	5.82	No	Yes	0	4	1
33	R:R:P111	R:R:W45	21.62	No	Yes	0	4	1
34	R:R:K294	R:R:V52	3.04	No	No	0	4	5
35	R:R:F295	R:R:V52	3.93	No	No	0	4	5
36	R:R:M106	R:R:M53	5.78	No	No	0	6	4
37	R:R:G56	R:R:L298	3.42	No	Yes	0	6	6
38	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
39	R:R:L298	R:R:V59	4.47	Yes	No	0	6	7
40	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
41	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
42	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
43	R:R:F96	R:R:M64	6.22	No	No	0	7	6
44	R:R:D95	R:R:N67	6.73	Yes	No	0	9	9
45	R:R:N67	R:R:P308	9.77	No	No	0	9	9
46	R:R:L68	R:R:M71	4.24	No	No	3	4	7
47	R:R:F96	R:R:L68	6.09	No	No	3	7	4
48	R:R:F322	R:R:L69	3.65	No	No	0	6	7
49	R:R:A92	R:R:V70	3.39	No	No	0	9	9
50	R:R:F96	R:R:M71	4.98	No	No	3	7	7
51	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
52	R:R:F80	R:R:I74	5.02	Yes	No	4	8	7
53	R:R:I74	R:R:Y85	3.63	No	Yes	4	7	9
54	R:R:N77	R:R:R79	10.85	No	No	0	6	6
55	R:R:F80	R:R:N77	7.25	Yes	No	0	8	6
56	R:R:N77	R:R:T321	5.85	No	No	0	6	7
57	R:R:F80	R:R:Y85	13.41	Yes	Yes	4	8	9
58	R:R:E317	R:R:F80	3.5	No	Yes	0	7	8
59	R:R:F80	R:R:M318	4.98	Yes	Yes	0	8	8
60	R:R:H81	R:R:Y86	3.27	No	No	0	8	4
61	R:R:F82	R:R:P83	4.33	No	No	0	7	6
62	R:R:F82	R:R:Y85	5.16	No	Yes	0	7	9
63	R:R:P83	R:R:V164	3.53	No	Yes	0	6	7
64	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
65	R:R:E145	R:R:I84	4.1	Yes	No	0	8	8
66	R:R:D315	R:R:Y85	6.9	No	Yes	0	8	9
67	R:R:A141	R:R:L87	3.15	No	No	0	8	8
68	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
69	R:R:I142	R:R:M88	7.29	No	No	2	8	8
70	R:R:M88	R:R:Y311	3.59	No	Yes	2	8	9
71	R:R:N138	R:R:N90	12.26	No	No	0	8	9
72	R:R:I168	R:R:N90	14.16	No	No	0	8	9
73	R:R:N90	R:R:W172	6.78	No	No	0	9	9
74	R:R:D95	R:R:L91	4.07	Yes	Yes	0	9	9
75	R:R:L91	R:R:N138	5.49	Yes	No	0	9	8
76	R:R:L139	R:R:L91	5.54	No	Yes	2	8	9
77	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
78	R:R:D95	R:R:S135	5.89	Yes	No	0	9	9
79	R:R:D95	R:R:S304	11.78	Yes	No	0	9	9
80	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
81	R:R:F97	R:R:T130	3.89	No	No	0	7	6
82	R:R:F97	R:R:S131	5.28	No	No	0	7	6
83	R:R:A98	R:R:S131	3.42	No	No	0	8	6
84	R:R:A98	R:R:S304	3.42	No	No	0	8	9
85	R:R:A101	R:R:S131	3.42	No	No	0	5	6
86	R:R:L105	R:R:Y102	3.52	No	Yes	0	6	7
87	R:R:M106	R:R:Y102	9.58	No	Yes	0	6	7
88	R:R:L297	R:R:Y102	3.52	No	Yes	0	6	7
89	R:R:L298	R:R:Y102	3.52	Yes	Yes	0	6	7
90	R:R:E301	R:R:Y102	16.83	No	Yes	0	7	7
91	R:R:F103	R:R:F107	8.57	No	No	0	6	5
92	R:R:N108	R:R:Y104	12.79	No	No	0	5	5
93	R:R:L123	R:R:Y104	3.52	No	No	0	4	5
94	R:R:L105	R:R:Q125	3.99	No	Yes	1	6	4
95	R:R:G110	R:R:T109	3.64	No	No	0	5	5
96	R:R:G110	R:R:P111	4.06	No	No	0	5	4
97	R:R:N112	R:R:R115	6.03	No	No	0	4	3
98	R:R:R124	R:R:T113	3.88	Yes	No	1	6	5
99	R:R:R114	R:R:R115	9.6	No	No	0	6	3
100	R:R:L116	R:R:R124	4.86	No	Yes	0	6	6
101	R:R:T117	R:R:T120	7.85	No	No	0	6	4
102	R:R:L201	R:R:V118	4.47	Yes	No	0	1	2
103	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
104	R:R:Q125	R:R:W121	9.86	Yes	Yes	1	4	9
105	R:R:L201	R:R:W121	17.08	Yes	Yes	1	1	9
106	R:R:W121	R:R:Y202	3.86	Yes	Yes	1	9	4
107	R:R:Q125	R:R:R124	14.02	Yes	Yes	1	4	6
108	R:R:I128	R:R:Q125	4.12	No	Yes	0	6	4
109	R:R:Q125	R:R:Y202	4.51	Yes	Yes	1	4	4
110	R:R:D129	R:R:Y202	6.9	Yes	Yes	1	5	4
111	R:R:D129	R:R:Y206	8.05	Yes	Yes	1	5	7
112	R:R:L132	R:R:W271	5.69	No	Yes	0	7	8
113	R:R:E301	R:R:L132	5.3	No	No	0	7	7
114	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
115	R:R:T133	R:R:W210	7.28	No	Yes	1	6	6
116	R:R:A134	R:R:W172	3.89	No	No	0	7	9
117	R:R:F213	R:R:V136	3.93	No	Yes	1	5	8
118	R:R:N214	R:R:V136	4.43	Yes	Yes	1	7	8
119	R:R:T217	R:R:V136	4.76	No	Yes	1	7	8
120	R:R:F267	R:R:V136	7.87	No	Yes	1	9	8
121	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
122	R:R:A137	R:R:I171	3.25	No	No	0	5	7
123	R:R:I171	R:R:N138	8.5	No	No	0	7	8
124	R:R:L139	R:R:N307	9.61	No	No	0	8	9
125	R:R:L139	R:R:Y311	4.69	No	Yes	2	8	9
126	R:R:L140	R:R:T217	5.9	No	No	0	7	7
127	R:R:I142	R:R:R146	6.26	No	No	2	8	9
128	R:R:I142	R:R:Y311	4.84	No	Yes	2	8	9
129	R:R:A143	R:R:Y225	5.34	No	Yes	0	8	9
130	R:R:E145	R:R:V164	4.28	Yes	Yes	0	8	7
131	R:R:R146	R:R:Y225	8.23	No	Yes	0	9	9
132	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
133	R:R:F151	R:R:H147	13.58	Yes	Yes	6	6	7
134	R:R:H147	R:R:L224	9	Yes	No	0	7	6
135	R:R:H147	R:R:H227	9.55	Yes	No	6	7	5
136	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
137	R:R:I148	R:R:R152	5.01	No	No	0	5	5
138	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
139	R:R:I228	R:R:V150	3.07	No	No	0	9	8
140	R:R:F151	R:R:H227	11.31	Yes	No	6	6	5
141	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
142	R:R:Q154	R:R:R158	15.19	No	No	0	4	3
143	R:R:L155	R:R:T157	5.9	No	No	0	8	4
144	R:R:H156	R:R:T157	5.48	No	No	0	4	4
145	R:R:R158	R:R:T157	3.88	No	No	0	3	4
146	R:R:R162	R:R:S160	5.27	No	No	0	5	8
147	R:R:V167	R:R:V170	3.21	No	No	0	6	3
148	R:R:M174	R:R:M178	4.33	No	Yes	0	4	5
149	R:R:I181	R:R:V177	3.07	No	No	0	5	4
150	R:R:M178	R:R:Y206	4.79	Yes	Yes	1	5	7
151	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
152	R:R:I181	R:R:P182	3.39	No	No	0	5	6
153	R:R:I181	R:R:W186	5.87	No	Yes	0	5	6
154	R:R:P182	R:R:Y202	11.13	No	Yes	1	6	4
155	R:R:P182	R:R:Y206	13.91	No	Yes	1	6	7
156	R:R:S183	R:R:V184	4.85	No	No	0	6	5
157	R:R:S203	R:R:W186	4.94	No	Yes	0	5	6
158	R:R:S205	R:R:W186	9.88	No	Yes	0	5	6
159	R:R:W186	R:R:Y206	4.82	Yes	Yes	0	6	7
160	R:R:F209	R:R:W186	4.01	No	Yes	0	6	6
161	R:R:I189	R:R:N187	11.33	No	No	0	3	6
162	R:R:C188	R:R:C195	7.28	No	No	0	5	9
163	R:R:C188	R:R:S203	3.44	No	No	0	5	5
164	R:R:I189	R:R:L201	4.28	No	Yes	1	3	1
165	R:R:D191	R:R:E193	10.39	No	No	0	4	4
166	R:R:D191	R:R:N194	4.04	No	No	0	4	3
167	R:R:D204	R:R:N194	12.12	No	No	0	4	3
168	R:R:L207	R:R:S196	9.01	No	No	7	6	5
169	R:R:D281	R:R:S196	4.42	Yes	No	7	4	5
170	R:R:D281	R:R:N197	12.12	Yes	No	0	4	5
171	R:R:D281	R:R:M198	8.32	Yes	No	0	4	3
172	R:R:M198	R:R:V289	4.56	No	No	0	3	4
173	R:R:E293	R:R:M198	4.06	Yes	No	0	4	3
174	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
175	R:R:Y202	R:R:Y206	3.97	Yes	Yes	1	4	7
176	R:R:D204	R:R:V282	5.84	No	No	0	4	5
177	R:R:D281	R:R:L207	4.07	Yes	No	7	4	6
178	R:R:V208	R:R:V282	4.81	No	No	0	4	5
179	R:R:N214	R:R:W210	14.69	Yes	Yes	1	7	6
180	R:R:W210	R:R:W271	3.75	Yes	Yes	1	6	8
181	R:R:A211	R:R:L275	3.15	No	No	0	4	6
182	R:R:A211	R:R:L279	4.73	No	No	0	4	6
183	R:R:F213	R:R:N214	7.25	No	Yes	1	5	7
184	R:R:F213	R:R:T217	5.19	No	No	1	5	7
185	R:R:L275	R:R:N214	5.49	No	Yes	0	6	7
186	R:R:F218	R:R:V222	6.55	No	No	0	5	4
187	R:R:F218	R:R:F267	10.72	No	No	0	5	9
188	R:R:F218	R:R:I268	6.28	No	No	0	5	6
189	R:R:V263	R:R:Y225	5.05	No	Yes	0	8	9
190	R:R:F229	R:R:M253	3.73	Yes	Yes	0	6	7
191	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
192	R:R:F229	R:R:L257	7.31	Yes	No	0	6	7
193	R:R:R235	R:R:Y231	5.14	No	No	0	7	6
194	R:R:M253	R:R:V232	3.04	Yes	Yes	0	7	7
195	R:R:L256	R:R:V232	4.47	No	Yes	0	7	7
196	R:R:M237	R:R:R233	7.44	No	No	0	5	5
197	R:R:R235	R:R:R238	14.93	No	No	0	7	5
198	R:R:N249	R:R:T236	5.85	No	No	0	4	5
199	R:R:H242	R:R:S240	6.97	No	No	0	4	4
200	R:R:S240	R:R:S243	4.89	No	No	0	4	3
201	R:R:H242	R:R:R241	14.67	No	No	0	4	4
202	R:R:R248	R:R:S244	10.54	No	No	0	4	5
203	R:R:G245	R:R:P246	4.06	No	No	0	1	4
204	R:R:M254	R:R:R250	4.96	No	No	0	5	4
205	R:R:M253	R:R:T252	3.01	Yes	No	0	7	5
206	R:R:R314	R:R:S255	3.95	No	No	0	7	7
207	R:R:I262	R:R:K258	4.36	No	No	0	6	7
208	R:R:K258	R:R:Y313	3.58	No	No	0	7	5
209	R:R:R314	R:R:T259	9.06	No	No	0	7	8
210	R:R:I262	R:R:I310	4.42	No	Yes	0	6	8
211	R:R:I310	R:R:V263	3.07	Yes	No	2	8	8
212	R:R:V263	R:R:Y311	3.79	No	Yes	2	8	9
213	R:R:F267	R:R:W271	11.02	No	Yes	1	9	8
214	R:R:I268	R:R:T272	3.04	No	No	0	6	5
215	R:R:C270	R:R:F302	4.19	Yes	No	8	9	5
216	R:R:C270	R:R:N303	6.3	Yes	No	0	9	9
217	R:R:C270	R:R:M306	3.24	Yes	No	8	9	6
218	R:R:N303	R:R:W271	6.78	No	Yes	0	9	8
219	R:R:P273	R:R:T272	3.5	No	No	0	9	5
220	R:R:F296	R:R:P273	8.67	Yes	No	0	5	9
221	R:R:L299	R:R:P273	4.93	No	No	0	7	9
222	R:R:F296	R:R:G274	3.01	Yes	No	0	5	5
223	R:R:L277	R:R:V289	4.47	No	No	0	4	4
224	R:R:L277	R:R:Y292	3.52	No	No	9	4	3
225	R:R:F296	R:R:L277	9.74	Yes	No	9	5	4
226	R:R:C284	R:R:L280	3.17	No	No	0	4	5
227	R:R:C284	R:R:C287	5.46	No	No	0	4	5
228	R:R:A291	R:R:D288	4.63	No	No	0	2	1
229	R:R:D288	R:R:Y292	4.6	No	No	0	1	3
230	R:R:E293	R:R:L290	5.3	Yes	No	1	4	3
231	R:R:F296	R:R:Y292	5.16	Yes	No	9	5	3
232	R:R:F302	R:R:M306	3.73	No	No	8	5	6
233	R:R:N303	R:R:N307	10.9	No	No	0	9	9
234	R:R:I310	R:R:Y311	6.04	Yes	Yes	2	8	9
235	R:R:M318	R:R:S312	3.07	Yes	No	0	8	7
236	R:R:R314	R:R:Y313	10.29	No	No	0	7	5
237	R:R:D315	R:R:E317	5.2	No	No	0	8	7
238	R:R:D315	R:R:M318	8.32	No	Yes	0	8	8
239	R:R:K316	R:R:S319	6.12	No	No	0	5	8
240	R:R:F322	R:R:M318	3.73	No	Yes	0	6	8
241	R:R:N46	R:R:S49	2.98	No	No	0	2	1
242	R:R:L140	R:R:V220	2.98	No	No	0	7	5
243	R:R:L264	R:R:V222	2.98	No	No	0	7	4
244	R:R:L257	R:R:V261	2.98	No	No	0	7	5
245	R:R:L116	R:R:T120	2.95	No	No	0	6	4
246	R:R:A42	R:R:H40	2.93	No	No	0	4	2
247	R:R:I84	R:R:M88	2.92	No	No	0	8	8
248	R:R:I144	R:R:L140	2.85	Yes	No	0	6	7
249	R:R:I144	R:R:L224	2.85	Yes	No	0	6	6
250	R:R:Q324	R:R:T321	2.83	No	No	0	4	7
251	R:R:C60	R:R:F103	2.79	No	No	0	6	6
252	R:R:A66	R:R:F62	2.77	No	No	0	8	4
253	R:R:L123	R:R:L127	2.77	No	No	0	4	5
254	R:R:M159	R:R:Q154	2.72	No	No	0	6	4
255	R:R:E317	R:R:K316	2.7	No	No	0	7	5
256	R:R:F32	R:R:S29	2.64	No	No	0	2	4
257	R:R:A94	R:R:W172	2.59	No	No	0	8	9
258	R:R:A300	R:R:W271	2.59	No	Yes	0	7	8
259	R:R:V260	R:R:Y225	2.52	No	Yes	0	8	9
260	R:R:F103	R:R:I57	2.51	No	No	0	6	4
261	R:R:F62	R:R:I309	2.51	No	No	0	4	7
262	R:R:M159	R:R:R152	2.48	No	No	0	6	5
263	R:R:S49	R:R:W45	2.47	No	Yes	0	1	1
264	R:R:F97	R:R:L127	2.44	No	No	0	7	5
265	R:R:K50	R:R:W45	2.32	No	Yes	0	3	1
266	R:R:R247	R:R:R248	2.13	No	No	0	3	4
267	R:R:A42	R:R:G110	1.95	No	No	0	4	5
268	R:R:C284	R:R:P285	1.88	No	No	0	4	3
269	R:R:A66	R:R:P308	1.87	No	No	0	8	9
270	R:R:G179	R:R:T130	1.82	No	No	0	7	6
271	R:R:A134	R:R:A175	1.79	No	No	0	7	8
272	R:R:P308	R:R:V70	1.77	No	No	0	9	9
273	R:R:G265	R:R:I268	1.76	No	No	0	4	6
274	R:R:A31	R:R:S29	1.71	No	No	0	2	4
275	R:R:G185	R:R:N187	1.7	No	No	0	5	6
276	R:R:D129	R:R:G126	1.68	Yes	No	0	5	6
277	R:R:C270	R:R:I269	1.64	Yes	No	0	9	5
278	R:R:N249	R:R:P246	1.63	No	No	0	4	4
279	R:R:C60	R:R:M64	1.62	No	No	0	6	6
280	R:R:A305	R:R:I63	1.62	No	Yes	0	7	8
281	R:R:A73	R:R:I325	1.62	No	No	0	7	6
282	R:R:A89	R:R:I74	1.62	No	No	0	7	7
283	R:R:A266	R:R:I310	1.62	No	Yes	0	6	8
284	R:R:A93	R:R:M71	1.61	No	No	0	6	7
285	R:R:A143	R:R:M221	1.61	No	No	0	8	9
286	R:R:S119	R:R:T117	1.6	No	No	0	1	6
287	R:R:V164	R:R:V165	1.6	Yes	No	5	7	1
288	R:R:V216	R:R:V220	1.6	No	No	0	4	5
289	R:R:T236	R:R:V232	1.59	No	Yes	0	5	7
290	R:R:T272	R:R:V276	1.59	No	No	0	5	6
291	R:R:I325	R:R:V72	1.54	No	No	0	6	5
292	R:R:I212	R:R:V208	1.54	No	No	0	4	4
293	R:R:I212	R:R:V216	1.54	No	No	0	4	4
294	R:R:I176	R:R:T130	1.52	No	No	0	3	6
295	R:R:A320	R:R:Q324	1.52	No	No	0	4	4
296	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
297	R:R:M239	R:R:T236	1.51	No	No	0	7	5
298	R:R:G230	R:R:R233	1.5	No	No	0	2	5
299	R:R:L87	R:R:V167	1.49	No	No	0	8	6
300	R:R:N161	R:R:S160	1.49	No	No	0	3	8
301	R:R:N161	R:R:V164	1.48	No	Yes	5	3	7
302	R:R:N161	R:R:V165	1.48	No	No	5	3	1
303	R:R:L55	R:R:T58	1.47	No	No	0	4	5
304	R:R:I144	R:R:I148	1.47	Yes	No	0	6	5
305	R:R:N46	R:R:T47	1.46	No	No	0	2	5
306	R:R:M253	R:R:M254	1.44	Yes	No	0	7	5
307	R:R:E145	R:R:T149	1.41	Yes	No	0	8	8
308	R:R:L51	R:R:L55	1.38	No	No	0	4	4
309	R:R:L298	R:R:L55	1.38	Yes	No	0	6	4
310	R:R:L326	R:R:L69	1.38	No	No	0	6	7
311	R:R:L215	R:R:L275	1.38	No	No	0	5	6
312	R:R:F295	R:R:V48	1.31	No	No	0	4	3
313	R:R:V164	R:R:Y86	1.26	Yes	No	0	7	4
314	R:R:V232	R:R:Y231	1.26	Yes	No	0	7	6
315	R:R:I144	R:R:R163	1.25	Yes	No	0	6	6
316	R:R:Q234	R:R:R235	1.17	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.77643	14	1	0
2	R:R:Y34	8.69667	6	1	6
3	R:R:K39	7.678	5	1	8
4	R:R:W45	8.0575	4	0	1
5	R:R:I63	3.655	4	0	8
6	R:R:F80	6.832	5	4	8
7	R:R:Y85	6.546	5	4	9
8	R:R:L91	4.655	4	2	9
9	R:R:D95	7.31	5	0	9
10	R:R:Y102	7.05833	6	0	7
11	R:R:W121	8.29	6	1	9
12	R:R:R124	7.4275	4	1	6
13	R:R:Q125	7.35333	6	1	4
14	R:R:D129	6.585	4	1	5
15	R:R:V136	5.178	5	1	8
16	R:R:I144	2.105	4	0	6
17	R:R:E145	3.7725	4	0	8
18	R:R:H147	9.3575	4	6	7
19	R:R:F151	10.3	4	6	6
20	R:R:V164	2.43	5	5	7
21	R:R:M178	5.035	4	1	5
22	R:R:W186	5.904	5	0	6
23	R:R:L201	10.11	4	1	1
24	R:R:Y202	5.39	7	1	4
25	R:R:Y206	7.108	5	1	7
26	R:R:W210	10.568	5	1	6
27	R:R:N214	7.965	4	1	7
28	R:R:Y225	5.285	4	0	9
29	R:R:F229	4.66	4	0	6
30	R:R:V232	2.59	4	0	7
31	R:R:M253	2.805	4	0	7
32	R:R:C270	3.8425	4	8	9
33	R:R:W271	5.78833	6	1	8
34	R:R:D281	7.2325	4	7	4
35	R:R:E293	6.4625	4	1	4
36	R:R:F296	6.645	4	9	5
37	R:R:L298	3.1975	4	0	6
38	R:R:I310	3.7875	4	2	8
39	R:R:Y311	4.66286	7	2	9
40	R:R:M318	4.664	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	28.4001	4.19	Yes	Yes	1	0	6
2	R:R:W121	R:R:Y34	16.3472	9.65	Yes	Yes	1	9	6
3	R:R:L201	R:R:W121	41.3076	17.08	Yes	Yes	1	1	9
4	R:R:F33	R:R:L201	22.597	14.61	No	Yes	1	6	1
5	R:R:F32	R:R:F33	18.9006	10.72	No	No	0	2	6
6	L:L:?1	R:R:Q125	16.9768	7.62	Yes	Yes	1	0	4
7	R:R:Q125	R:R:W121	17.2159	9.86	Yes	Yes	1	4	9
8	L:L:?1	R:R:Y202	24.5103	3.36	Yes	Yes	1	0	4
9	R:R:W121	R:R:Y202	15.9849	3.86	Yes	Yes	1	9	4
10	R:R:I189	R:R:L201	11.2967	4.28	No	Yes	1	3	1
11	L:L:?1	R:R:E293	19.3472	5.69	Yes	Yes	1	0	4
12	R:R:L105	R:R:Y102	11.9333	3.52	No	Yes	0	6	7
13	L:L:?1	R:R:T109	14.3882	8.44	Yes	No	0	0	5
14	R:R:G110	R:R:T109	12.9005	3.64	No	No	0	5	5
15	R:R:L298	R:R:Y102	19.5196	3.52	Yes	Yes	0	6	7
16	R:R:L298	R:R:V59	16.4773	4.47	Yes	No	0	6	7
17	R:R:I63	R:R:V59	15.883	3.07	Yes	No	0	8	7
18	R:R:C60	R:R:Y102	14.2581	5.38	No	Yes	0	6	7
19	R:R:I63	R:R:S304	15.7247	4.64	Yes	No	0	8	9
20	L:L:?1	R:R:W210	100	23.63	Yes	Yes	1	0	6
21	R:R:W210	R:R:W271	72.0853	3.75	Yes	Yes	1	6	8
22	R:R:N303	R:R:W271	85.3726	6.78	No	Yes	0	9	8
23	R:R:N303	R:R:N307	83.5438	10.9	No	No	0	9	9
24	R:R:D95	R:R:N307	20.9862	8.08	Yes	No	0	9	9
25	R:R:D95	R:R:S304	19.6919	11.78	Yes	No	0	9	9
26	R:R:L139	R:R:N307	62.4134	9.61	No	No	0	8	9
27	R:R:L139	R:R:Y311	54.7392	4.69	No	Yes	2	8	9
28	R:R:M88	R:R:Y311	52.4461	3.59	No	Yes	2	8	9
29	R:R:I84	R:R:M88	52.6008	2.92	No	No	0	8	8
30	R:R:I84	R:R:Y85	38.1106	3.63	No	Yes	0	8	9
31	R:R:F80	R:R:Y85	19.6708	13.41	Yes	Yes	4	8	9
32	R:R:D315	R:R:Y85	13.9486	6.9	No	Yes	0	8	9
33	R:R:E145	R:R:I84	16.5266	4.1	Yes	No	0	8	8
34	R:R:D95	R:R:L91	20.4305	4.07	Yes	Yes	0	9	9
35	R:R:L91	R:R:N138	16.4879	5.49	Yes	No	0	9	8
36	R:R:N138	R:R:N90	11.0541	12.26	No	No	0	8	9
37	R:R:A98	R:R:S304	15.4328	3.42	No	No	0	8	9
38	R:R:A98	R:R:S131	14.0646	3.42	No	No	0	8	6
39	R:R:F97	R:R:S131	11.3073	5.28	No	No	0	7	6
40	R:R:E301	R:R:Y102	11.0576	16.83	No	Yes	0	7	7
41	R:R:L132	R:R:W271	11.972	5.69	No	Yes	0	7	8
42	R:R:N214	R:R:W210	47.9162	14.69	Yes	Yes	1	7	6
43	R:R:F213	R:R:N214	22.5091	7.25	No	Yes	1	5	7
44	R:R:N214	R:R:V136	24.8233	4.43	Yes	Yes	1	7	8
45	R:R:V136	R:R:W271	53.241	4.9	Yes	Yes	1	8	8
46	R:R:T217	R:R:V136	74.9341	4.76	No	Yes	1	7	8
47	R:R:F213	R:R:T217	22.1609	5.19	No	No	1	5	7
48	R:R:F267	R:R:W271	10.3295	11.02	No	Yes	1	9	8
49	R:R:L140	R:R:T217	95.5087	5.9	No	No	0	7	7
50	R:R:I144	R:R:L140	79.2248	2.85	Yes	No	0	6	7
51	R:R:I144	R:R:L224	62.4697	2.85	Yes	No	0	6	6
52	R:R:H147	R:R:L224	60.7322	9	Yes	No	0	7	6
53	R:R:F151	R:R:H147	53.5047	13.58	Yes	Yes	6	6	7
54	R:R:I144	R:R:I148	15.4082	1.47	Yes	No	0	6	5
55	R:R:I148	R:R:R152	13.4878	5.01	No	No	0	5	5
56	R:R:M159	R:R:R152	11.5605	2.48	No	No	0	6	5
57	R:R:M178	R:R:W210	15.5735	3.49	Yes	Yes	1	5	6
58	R:R:W186	R:R:Y206	13.9662	4.82	Yes	Yes	0	6	7
59	R:R:L140	R:R:V220	17.4691	2.98	No	No	0	7	5
60	R:R:V216	R:R:V220	15.5559	1.6	No	No	0	4	5
61	R:R:I212	R:R:V216	13.6356	1.54	No	No	0	4	4
62	R:R:I212	R:R:V208	11.7082	1.54	No	No	0	4	4
63	R:R:E293	R:R:M198	17.5008	4.06	Yes	No	0	4	3
64	R:R:F218	R:R:F267	12.6754	10.72	No	No	0	5	9
65	R:R:F151	R:R:Y231	50.1424	12.38	Yes	No	0	6	6
66	R:R:V232	R:R:Y231	43.0978	1.26	Yes	No	0	7	6
67	R:R:M253	R:R:V232	18.992	3.04	Yes	Yes	0	7	7
68	R:R:F229	R:R:M253	11.564	3.73	Yes	Yes	0	6	7
69	R:R:L256	R:R:V232	13.2487	4.47	No	Yes	0	7	7
70	R:R:F229	R:R:L256	11.4972	6.09	Yes	No	0	6	7
71	R:R:F229	R:R:G230	11.5605	1.51	Yes	No	0	6	2
72	R:R:E301	R:R:L132	11.047	5.3	No	No	0	7	7
73	R:R:M178	R:R:Y206	13.1678	4.79	Yes	Yes	1	5	7
74	R:R:L91	R:R:Y311	14.0295	3.52	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y34	4.19	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	8.07	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L105	4.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:T109	8.44	1	Yes	No	0	5	0	1
L:L:?1	R:R:T113	6.33	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	6.95	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	7.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	9.71	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y202	3.36	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W210	23.63	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	5.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	5.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	7.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	6.93	1	Yes	No	0	6	0	1
R:R:I30	R:R:Y34	3.63	1	No	Yes	6	6	2	1
R:R:I30	R:R:W121	5.87	1	No	Yes	6	9	2	2
R:R:K39	R:R:Y34	11.94	1	Yes	Yes	8	6	1	1
R:R:L41	R:R:Y34	4.69	0	No	Yes	2	6	2	1
R:R:W121	R:R:Y34	9.65	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	18.08	1	No	Yes	6	6	2	1
R:R:K39	R:R:P200	3.35	1	Yes	No	8	6	1	2
R:R:K39	R:R:L290	4.23	1	Yes	No	8	3	1	2
R:R:E293	R:R:K39	10.8	1	Yes	Yes	4	8	1	1
R:R:K294	R:R:V52	3.04	0	No	No	4	5	1	2
R:R:L105	R:R:Y102	3.52	1	No	Yes	6	7	1	2
R:R:L297	R:R:Y102	3.52	0	No	Yes	6	7	1	2
R:R:L105	R:R:Q125	3.99	1	No	Yes	6	4	1	1
R:R:G110	R:R:T109	3.64	0	No	No	5	5	2	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:Q125	R:R:W121	9.86	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	3.86	1	Yes	Yes	9	4	2	1
R:R:Q125	R:R:R124	14.02	1	Yes	Yes	4	6	1	1
R:R:I128	R:R:Q125	4.12	0	No	Yes	6	4	2	1
R:R:Q125	R:R:Y202	4.51	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:Y202	6.9	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	8.05	1	Yes	Yes	5	7	1	2
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	7.28	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	4.79	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	11.13	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	13.91	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	4.06	1	Yes	No	4	3	1	2
R:R:A199	R:R:Y202	4	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	3.97	1	Yes	Yes	4	7	1	2
R:R:N214	R:R:W210	14.69	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	3.75	1	Yes	Yes	6	8	1	2
R:R:E293	R:R:L290	5.3	1	Yes	No	4	3	1	2
R:R:D129	R:R:G126	1.68	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	276
Number of Links	316
Number of Hubs	40
Number of Links mediated by Hubs	160
Number of Communities	9
Number of Nodes involved in Communities	57
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	68981
Length Of Smallest Path	3
Average Path Length	13.1599
Length of Longest Path	27
Minimum Path Strength	1.36
Average Path Strength	6.67125
Maximum Path Strength	19.16
Minimum Path Correlation	0.7
Average Path Correlation	0.926774
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.0655
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3712
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9IZG_nogp_Chain_R S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R H S S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Q I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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