psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	4.19	Yes	Yes	1	0	6
2	L:L:?1	R:R:K39	8.07	Yes	Yes	1	0	8
3	L:L:?1	R:R:L105	4.95	Yes	No	1	0	6
4	L:L:?1	R:R:T109	8.44	Yes	No	0	0	5
5	L:L:?1	R:R:T113	6.33	Yes	No	1	0	5
6	L:L:?1	R:R:R124	6.95	Yes	Yes	1	0	6
7	L:L:?1	R:R:Q125	7.62	Yes	Yes	1	0	4
8	L:L:?1	R:R:D129	9.71	Yes	Yes	1	0	5
9	L:L:?1	R:R:Y202	3.36	Yes	Yes	1	0	4
10	L:L:?1	R:R:W210	23.63	Yes	Yes	1	0	6
11	L:L:?1	R:R:L278	5.94	Yes	No	0	0	6
12	L:L:?1	R:R:E293	5.69	Yes	Yes	1	0	4
13	L:L:?1	R:R:K294	7.06	Yes	No	0	0	4
14	L:L:?1	R:R:L297	6.93	Yes	No	0	0	6
15	R:R:I30	R:R:Y34	3.63	No	Yes	1	6	6
16	R:R:I30	R:R:W121	5.87	No	Yes	1	6	9
17	R:R:F32	R:R:F33	10.72	No	No	0	2	6
18	R:R:F32	R:R:R36	11.76	No	No	0	2	3
19	R:R:F33	R:R:I189	5.02	No	No	1	6	3
20	R:R:F33	R:R:L201	14.61	No	Yes	1	6	1
21	R:R:K39	R:R:Y34	11.94	Yes	Yes	1	8	6
22	R:R:L41	R:R:Y34	4.69	No	Yes	0	2	6
23	R:R:W121	R:R:Y34	9.65	Yes	Yes	1	9	6
24	R:R:P200	R:R:Y34	18.08	No	Yes	1	6	6
25	R:R:I192	R:R:R36	8.77	No	No	0	1	3
26	R:R:P200	R:R:S37	7.13	No	No	0	6	7
27	R:R:K39	R:R:P200	3.35	Yes	No	1	8	6
28	R:R:K39	R:R:L290	4.23	Yes	No	1	8	3
29	R:R:E293	R:R:K39	10.8	Yes	Yes	1	4	8
30	R:R:L41	R:R:R114	4.86	No	No	0	2	6
31	R:R:R114	R:R:T43	3.88	No	No	0	6	3
32	R:R:M53	R:R:W45	5.82	No	Yes	0	4	1
33	R:R:P111	R:R:W45	21.62	No	Yes	0	4	1
34	R:R:K294	R:R:V52	3.04	No	No	0	4	5
35	R:R:F295	R:R:V52	3.93	No	No	0	4	5
36	R:R:M106	R:R:M53	5.78	No	No	0	6	4
37	R:R:G56	R:R:L298	3.42	No	Yes	0	6	6
38	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
39	R:R:L298	R:R:V59	4.47	Yes	No	0	6	7
40	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
41	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
42	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
43	R:R:F96	R:R:M64	6.22	No	No	0	7	6
44	R:R:D95	R:R:N67	6.73	Yes	No	0	9	9
45	R:R:N67	R:R:P308	9.77	No	No	0	9	9
46	R:R:L68	R:R:M71	4.24	No	No	3	4	7
47	R:R:F96	R:R:L68	6.09	No	No	3	7	4
48	R:R:F322	R:R:L69	3.65	No	No	0	6	7
49	R:R:A92	R:R:V70	3.39	No	No	0	9	9
50	R:R:F96	R:R:M71	4.98	No	No	3	7	7
51	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
52	R:R:F80	R:R:I74	5.02	Yes	No	4	8	7
53	R:R:I74	R:R:Y85	3.63	No	Yes	4	7	9
54	R:R:N77	R:R:R79	10.85	No	No	0	6	6
55	R:R:F80	R:R:N77	7.25	Yes	No	0	8	6
56	R:R:N77	R:R:T321	5.85	No	No	0	6	7
57	R:R:F80	R:R:Y85	13.41	Yes	Yes	4	8	9
58	R:R:E317	R:R:F80	3.5	No	Yes	0	7	8
59	R:R:F80	R:R:M318	4.98	Yes	Yes	0	8	8
60	R:R:H81	R:R:Y86	3.27	No	No	0	8	4
61	R:R:F82	R:R:P83	4.33	No	No	0	7	6
62	R:R:F82	R:R:Y85	5.16	No	Yes	0	7	9
63	R:R:P83	R:R:V164	3.53	No	Yes	0	6	7
64	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
65	R:R:E145	R:R:I84	4.1	Yes	No	0	8	8
66	R:R:D315	R:R:Y85	6.9	No	Yes	0	8	9
67	R:R:A141	R:R:L87	3.15	No	No	0	8	8
68	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
69	R:R:I142	R:R:M88	7.29	No	No	2	8	8
70	R:R:M88	R:R:Y311	3.59	No	Yes	2	8	9
71	R:R:N138	R:R:N90	12.26	No	No	0	8	9
72	R:R:I168	R:R:N90	14.16	No	No	0	8	9
73	R:R:N90	R:R:W172	6.78	No	No	0	9	9
74	R:R:D95	R:R:L91	4.07	Yes	Yes	0	9	9
75	R:R:L91	R:R:N138	5.49	Yes	No	0	9	8
76	R:R:L139	R:R:L91	5.54	No	Yes	2	8	9
77	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
78	R:R:D95	R:R:S135	5.89	Yes	No	0	9	9
79	R:R:D95	R:R:S304	11.78	Yes	No	0	9	9
80	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
81	R:R:F97	R:R:T130	3.89	No	No	0	7	6
82	R:R:F97	R:R:S131	5.28	No	No	0	7	6
83	R:R:A98	R:R:S131	3.42	No	No	0	8	6
84	R:R:A98	R:R:S304	3.42	No	No	0	8	9
85	R:R:A101	R:R:S131	3.42	No	No	0	5	6
86	R:R:L105	R:R:Y102	3.52	No	Yes	0	6	7
87	R:R:M106	R:R:Y102	9.58	No	Yes	0	6	7
88	R:R:L297	R:R:Y102	3.52	No	Yes	0	6	7
89	R:R:L298	R:R:Y102	3.52	Yes	Yes	0	6	7
90	R:R:E301	R:R:Y102	16.83	No	Yes	0	7	7
91	R:R:F103	R:R:F107	8.57	No	No	0	6	5
92	R:R:N108	R:R:Y104	12.79	No	No	0	5	5
93	R:R:L123	R:R:Y104	3.52	No	No	0	4	5
94	R:R:L105	R:R:Q125	3.99	No	Yes	1	6	4
95	R:R:G110	R:R:T109	3.64	No	No	0	5	5
96	R:R:G110	R:R:P111	4.06	No	No	0	5	4
97	R:R:N112	R:R:R115	6.03	No	No	0	4	3
98	R:R:R124	R:R:T113	3.88	Yes	No	1	6	5
99	R:R:R114	R:R:R115	9.6	No	No	0	6	3
100	R:R:L116	R:R:R124	4.86	No	Yes	0	6	6
101	R:R:T117	R:R:T120	7.85	No	No	0	6	4
102	R:R:L201	R:R:V118	4.47	Yes	No	0	1	2
103	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
104	R:R:Q125	R:R:W121	9.86	Yes	Yes	1	4	9
105	R:R:L201	R:R:W121	17.08	Yes	Yes	1	1	9
106	R:R:W121	R:R:Y202	3.86	Yes	Yes	1	9	4
107	R:R:Q125	R:R:R124	14.02	Yes	Yes	1	4	6
108	R:R:I128	R:R:Q125	4.12	No	Yes	0	6	4
109	R:R:Q125	R:R:Y202	4.51	Yes	Yes	1	4	4
110	R:R:D129	R:R:Y202	6.9	Yes	Yes	1	5	4
111	R:R:D129	R:R:Y206	8.05	Yes	Yes	1	5	7
112	R:R:L132	R:R:W271	5.69	No	Yes	0	7	8
113	R:R:E301	R:R:L132	5.3	No	No	0	7	7
114	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
115	R:R:T133	R:R:W210	7.28	No	Yes	1	6	6
116	R:R:A134	R:R:W172	3.89	No	No	0	7	9
117	R:R:F213	R:R:V136	3.93	No	Yes	1	5	8
118	R:R:N214	R:R:V136	4.43	Yes	Yes	1	7	8
119	R:R:T217	R:R:V136	4.76	No	Yes	1	7	8
120	R:R:F267	R:R:V136	7.87	No	Yes	1	9	8
121	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
122	R:R:A137	R:R:I171	3.25	No	No	0	5	7
123	R:R:I171	R:R:N138	8.5	No	No	0	7	8
124	R:R:L139	R:R:N307	9.61	No	No	0	8	9
125	R:R:L139	R:R:Y311	4.69	No	Yes	2	8	9
126	R:R:L140	R:R:T217	5.9	No	No	0	7	7
127	R:R:I142	R:R:R146	6.26	No	No	2	8	9
128	R:R:I142	R:R:Y311	4.84	No	Yes	2	8	9
129	R:R:A143	R:R:Y225	5.34	No	Yes	0	8	9
130	R:R:E145	R:R:V164	4.28	Yes	Yes	0	8	7
131	R:R:R146	R:R:Y225	8.23	No	Yes	0	9	9
132	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
133	R:R:F151	R:R:H147	13.58	Yes	Yes	6	6	7
134	R:R:H147	R:R:L224	9	Yes	No	0	7	6
135	R:R:H147	R:R:H227	9.55	Yes	No	6	7	5
136	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
137	R:R:I148	R:R:R152	5.01	No	No	0	5	5
138	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
139	R:R:I228	R:R:V150	3.07	No	No	0	9	8
140	R:R:F151	R:R:H227	11.31	Yes	No	6	6	5
141	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
142	R:R:Q154	R:R:R158	15.19	No	No	0	4	3
143	R:R:L155	R:R:T157	5.9	No	No	0	8	4
144	R:R:H156	R:R:T157	5.48	No	No	0	4	4
145	R:R:R158	R:R:T157	3.88	No	No	0	3	4
146	R:R:R162	R:R:S160	5.27	No	No	0	5	8
147	R:R:V167	R:R:V170	3.21	No	No	0	6	3
148	R:R:M174	R:R:M178	4.33	No	Yes	0	4	5
149	R:R:I181	R:R:V177	3.07	No	No	0	5	4
150	R:R:M178	R:R:Y206	4.79	Yes	Yes	1	5	7
151	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
152	R:R:I181	R:R:P182	3.39	No	No	0	5	6
153	R:R:I181	R:R:W186	5.87	No	Yes	0	5	6
154	R:R:P182	R:R:Y202	11.13	No	Yes	1	6	4
155	R:R:P182	R:R:Y206	13.91	No	Yes	1	6	7
156	R:R:S183	R:R:V184	4.85	No	No	0	6	5
157	R:R:S203	R:R:W186	4.94	No	Yes	0	5	6
158	R:R:S205	R:R:W186	9.88	No	Yes	0	5	6
159	R:R:W186	R:R:Y206	4.82	Yes	Yes	0	6	7
160	R:R:F209	R:R:W186	4.01	No	Yes	0	6	6
161	R:R:I189	R:R:N187	11.33	No	No	0	3	6
162	R:R:C188	R:R:C195	7.28	No	No	0	5	9
163	R:R:C188	R:R:S203	3.44	No	No	0	5	5
164	R:R:I189	R:R:L201	4.28	No	Yes	1	3	1
165	R:R:D191	R:R:E193	10.39	No	No	0	4	4
166	R:R:D191	R:R:N194	4.04	No	No	0	4	3
167	R:R:D204	R:R:N194	12.12	No	No	0	4	3
168	R:R:L207	R:R:S196	9.01	No	No	7	6	5
169	R:R:D281	R:R:S196	4.42	Yes	No	7	4	5
170	R:R:D281	R:R:N197	12.12	Yes	No	0	4	5
171	R:R:D281	R:R:M198	8.32	Yes	No	0	4	3
172	R:R:M198	R:R:V289	4.56	No	No	0	3	4
173	R:R:E293	R:R:M198	4.06	Yes	No	0	4	3
174	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
175	R:R:Y202	R:R:Y206	3.97	Yes	Yes	1	4	7
176	R:R:D204	R:R:V282	5.84	No	No	0	4	5
177	R:R:D281	R:R:L207	4.07	Yes	No	7	4	6
178	R:R:V208	R:R:V282	4.81	No	No	0	4	5
179	R:R:N214	R:R:W210	14.69	Yes	Yes	1	7	6
180	R:R:W210	R:R:W271	3.75	Yes	Yes	1	6	8
181	R:R:A211	R:R:L275	3.15	No	No	0	4	6
182	R:R:A211	R:R:L279	4.73	No	No	0	4	6
183	R:R:F213	R:R:N214	7.25	No	Yes	1	5	7
184	R:R:F213	R:R:T217	5.19	No	No	1	5	7
185	R:R:L275	R:R:N214	5.49	No	Yes	0	6	7
186	R:R:F218	R:R:V222	6.55	No	No	0	5	4
187	R:R:F218	R:R:F267	10.72	No	No	0	5	9
188	R:R:F218	R:R:I268	6.28	No	No	0	5	6
189	R:R:V263	R:R:Y225	5.05	No	Yes	0	8	9
190	R:R:F229	R:R:M253	3.73	Yes	Yes	0	6	7
191	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
192	R:R:F229	R:R:L257	7.31	Yes	No	0	6	7
193	R:R:R235	R:R:Y231	5.14	No	No	0	7	6
194	R:R:M253	R:R:V232	3.04	Yes	Yes	0	7	7
195	R:R:L256	R:R:V232	4.47	No	Yes	0	7	7
196	R:R:M237	R:R:R233	7.44	No	No	0	5	5
197	R:R:R235	R:R:R238	14.93	No	No	0	7	5
198	R:R:N249	R:R:T236	5.85	No	No	0	4	5
199	R:R:H242	R:R:S240	6.97	No	No	0	4	4
200	R:R:S240	R:R:S243	4.89	No	No	0	4	3
201	R:R:H242	R:R:R241	14.67	No	No	0	4	4
202	R:R:R248	R:R:S244	10.54	No	No	0	4	5
203	R:R:G245	R:R:P246	4.06	No	No	0	1	4
204	R:R:M254	R:R:R250	4.96	No	No	0	5	4
205	R:R:M253	R:R:T252	3.01	Yes	No	0	7	5
206	R:R:R314	R:R:S255	3.95	No	No	0	7	7
207	R:R:I262	R:R:K258	4.36	No	No	0	6	7
208	R:R:K258	R:R:Y313	3.58	No	No	0	7	5
209	R:R:R314	R:R:T259	9.06	No	No	0	7	8
210	R:R:I262	R:R:I310	4.42	No	Yes	0	6	8
211	R:R:I310	R:R:V263	3.07	Yes	No	2	8	8
212	R:R:V263	R:R:Y311	3.79	No	Yes	2	8	9
213	R:R:F267	R:R:W271	11.02	No	Yes	1	9	8
214	R:R:I268	R:R:T272	3.04	No	No	0	6	5
215	R:R:C270	R:R:F302	4.19	Yes	No	8	9	5
216	R:R:C270	R:R:N303	6.3	Yes	No	0	9	9
217	R:R:C270	R:R:M306	3.24	Yes	No	8	9	6
218	R:R:N303	R:R:W271	6.78	No	Yes	0	9	8
219	R:R:P273	R:R:T272	3.5	No	No	0	9	5
220	R:R:F296	R:R:P273	8.67	Yes	No	0	5	9
221	R:R:L299	R:R:P273	4.93	No	No	0	7	9
222	R:R:F296	R:R:G274	3.01	Yes	No	0	5	5
223	R:R:L277	R:R:V289	4.47	No	No	0	4	4
224	R:R:L277	R:R:Y292	3.52	No	No	9	4	3
225	R:R:F296	R:R:L277	9.74	Yes	No	9	5	4
226	R:R:C284	R:R:L280	3.17	No	No	0	4	5
227	R:R:C284	R:R:C287	5.46	No	No	0	4	5
228	R:R:A291	R:R:D288	4.63	No	No	0	2	1
229	R:R:D288	R:R:Y292	4.6	No	No	0	1	3
230	R:R:E293	R:R:L290	5.3	Yes	No	1	4	3
231	R:R:F296	R:R:Y292	5.16	Yes	No	9	5	3
232	R:R:F302	R:R:M306	3.73	No	No	8	5	6
233	R:R:N303	R:R:N307	10.9	No	No	0	9	9
234	R:R:I310	R:R:Y311	6.04	Yes	Yes	2	8	9
235	R:R:M318	R:R:S312	3.07	Yes	No	0	8	7
236	R:R:R314	R:R:Y313	10.29	No	No	0	7	5
237	R:R:D315	R:R:E317	5.2	No	No	0	8	7
238	R:R:D315	R:R:M318	8.32	No	Yes	0	8	8
239	R:R:K316	R:R:S319	6.12	No	No	0	5	8
240	R:R:F322	R:R:M318	3.73	No	Yes	0	6	8
241	R:R:N46	R:R:S49	2.98	No	No	0	2	1
242	R:R:L140	R:R:V220	2.98	No	No	0	7	5
243	R:R:L264	R:R:V222	2.98	No	No	0	7	4
244	R:R:L257	R:R:V261	2.98	No	No	0	7	5
245	R:R:L116	R:R:T120	2.95	No	No	0	6	4
246	R:R:A42	R:R:H40	2.93	No	No	0	4	2
247	R:R:I84	R:R:M88	2.92	No	No	0	8	8
248	R:R:I144	R:R:L140	2.85	Yes	No	0	6	7
249	R:R:I144	R:R:L224	2.85	Yes	No	0	6	6
250	R:R:Q324	R:R:T321	2.83	No	No	0	4	7
251	R:R:C60	R:R:F103	2.79	No	No	0	6	6
252	R:R:A66	R:R:F62	2.77	No	No	0	8	4
253	R:R:L123	R:R:L127	2.77	No	No	0	4	5
254	R:R:M159	R:R:Q154	2.72	No	No	0	6	4
255	R:R:E317	R:R:K316	2.7	No	No	0	7	5
256	R:R:F32	R:R:S29	2.64	No	No	0	2	4
257	R:R:A94	R:R:W172	2.59	No	No	0	8	9
258	R:R:A300	R:R:W271	2.59	No	Yes	0	7	8
259	R:R:V260	R:R:Y225	2.52	No	Yes	0	8	9
260	R:R:F103	R:R:I57	2.51	No	No	0	6	4
261	R:R:F62	R:R:I309	2.51	No	No	0	4	7
262	R:R:M159	R:R:R152	2.48	No	No	0	6	5
263	R:R:S49	R:R:W45	2.47	No	Yes	0	1	1
264	R:R:F97	R:R:L127	2.44	No	No	0	7	5
265	R:R:K50	R:R:W45	2.32	No	Yes	0	3	1
266	R:R:R247	R:R:R248	2.13	No	No	0	3	4
267	R:R:A42	R:R:G110	1.95	No	No	0	4	5
268	R:R:C284	R:R:P285	1.88	No	No	0	4	3
269	R:R:A66	R:R:P308	1.87	No	No	0	8	9
270	R:R:G179	R:R:T130	1.82	No	No	0	7	6
271	R:R:A134	R:R:A175	1.79	No	No	0	7	8
272	R:R:P308	R:R:V70	1.77	No	No	0	9	9
273	R:R:G265	R:R:I268	1.76	No	No	0	4	6
274	R:R:A31	R:R:S29	1.71	No	No	0	2	4
275	R:R:G185	R:R:N187	1.7	No	No	0	5	6
276	R:R:D129	R:R:G126	1.68	Yes	No	0	5	6
277	R:R:C270	R:R:I269	1.64	Yes	No	0	9	5
278	R:R:N249	R:R:P246	1.63	No	No	0	4	4
279	R:R:C60	R:R:M64	1.62	No	No	0	6	6
280	R:R:A305	R:R:I63	1.62	No	Yes	0	7	8
281	R:R:A73	R:R:I325	1.62	No	No	0	7	6
282	R:R:A89	R:R:I74	1.62	No	No	0	7	7
283	R:R:A266	R:R:I310	1.62	No	Yes	0	6	8
284	R:R:A93	R:R:M71	1.61	No	No	0	6	7
285	R:R:A143	R:R:M221	1.61	No	No	0	8	9
286	R:R:S119	R:R:T117	1.6	No	No	0	1	6
287	R:R:V164	R:R:V165	1.6	Yes	No	5	7	1
288	R:R:V216	R:R:V220	1.6	No	No	0	4	5
289	R:R:T236	R:R:V232	1.59	No	Yes	0	5	7
290	R:R:T272	R:R:V276	1.59	No	No	0	5	6
291	R:R:I325	R:R:V72	1.54	No	No	0	6	5
292	R:R:I212	R:R:V208	1.54	No	No	0	4	4
293	R:R:I212	R:R:V216	1.54	No	No	0	4	4
294	R:R:I176	R:R:T130	1.52	No	No	0	3	6
295	R:R:A320	R:R:Q324	1.52	No	No	0	4	4
296	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
297	R:R:M239	R:R:T236	1.51	No	No	0	7	5
298	R:R:G230	R:R:R233	1.5	No	No	0	2	5
299	R:R:L87	R:R:V167	1.49	No	No	0	8	6
300	R:R:N161	R:R:S160	1.49	No	No	0	3	8
301	R:R:N161	R:R:V164	1.48	No	Yes	5	3	7
302	R:R:N161	R:R:V165	1.48	No	No	5	3	1
303	R:R:L55	R:R:T58	1.47	No	No	0	4	5
304	R:R:I144	R:R:I148	1.47	Yes	No	0	6	5
305	R:R:N46	R:R:T47	1.46	No	No	0	2	5
306	R:R:M253	R:R:M254	1.44	Yes	No	0	7	5
307	R:R:E145	R:R:T149	1.41	Yes	No	0	8	8
308	R:R:L51	R:R:L55	1.38	No	No	0	4	4
309	R:R:L298	R:R:L55	1.38	Yes	No	0	6	4
310	R:R:L326	R:R:L69	1.38	No	No	0	6	7
311	R:R:L215	R:R:L275	1.38	No	No	0	5	6
312	R:R:F295	R:R:V48	1.31	No	No	0	4	3
313	R:R:V164	R:R:Y86	1.26	Yes	No	0	7	4
314	R:R:V232	R:R:Y231	1.26	Yes	No	0	7	6
315	R:R:I144	R:R:R163	1.25	Yes	No	0	6	6
316	R:R:Q234	R:R:R235	1.17	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.77643	14	1	0
2	R:R:Y34	8.69667	6	1	6
3	R:R:K39	7.678	5	1	8
4	R:R:W45	8.0575	4	0	1
5	R:R:I63	3.655	4	0	8
6	R:R:F80	6.832	5	4	8
7	R:R:Y85	6.546	5	4	9
8	R:R:L91	4.655	4	2	9
9	R:R:D95	7.31	5	0	9
10	R:R:Y102	7.05833	6	0	7
11	R:R:W121	8.29	6	1	9
12	R:R:R124	7.4275	4	1	6
13	R:R:Q125	7.35333	6	1	4
14	R:R:D129	6.585	4	1	5
15	R:R:V136	5.178	5	1	8
16	R:R:I144	2.105	4	0	6
17	R:R:E145	3.7725	4	0	8
18	R:R:H147	9.3575	4	6	7
19	R:R:F151	10.3	4	6	6
20	R:R:V164	2.43	5	5	7
21	R:R:M178	5.035	4	1	5
22	R:R:W186	5.904	5	0	6
23	R:R:L201	10.11	4	1	1
24	R:R:Y202	5.39	7	1	4
25	R:R:Y206	7.108	5	1	7
26	R:R:W210	10.568	5	1	6
27	R:R:N214	7.965	4	1	7
28	R:R:Y225	5.285	4	0	9
29	R:R:F229	4.66	4	0	6
30	R:R:V232	2.59	4	0	7
31	R:R:M253	2.805	4	0	7
32	R:R:C270	3.8425	4	8	9
33	R:R:W271	5.78833	6	1	8
34	R:R:D281	7.2325	4	7	4
35	R:R:E293	6.4625	4	1	4
36	R:R:F296	6.645	4	9	5
37	R:R:L298	3.1975	4	0	6
38	R:R:I310	3.7875	4	2	8
39	R:R:Y311	4.66286	7	2	9
40	R:R:M318	4.664	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	28.4001	4.19	Yes	Yes	1	0	6
2	R:R:W121	R:R:Y34	16.3472	9.65	Yes	Yes	1	9	6
3	R:R:L201	R:R:W121	41.3076	17.08	Yes	Yes	1	1	9
4	R:R:F33	R:R:L201	22.597	14.61	No	Yes	1	6	1
5	R:R:F32	R:R:F33	18.9006	10.72	No	No	0	2	6
6	L:L:?1	R:R:Q125	16.9768	7.62	Yes	Yes	1	0	4
7	R:R:Q125	R:R:W121	17.2159	9.86	Yes	Yes	1	4	9
8	L:L:?1	R:R:Y202	24.5103	3.36	Yes	Yes	1	0	4
9	R:R:W121	R:R:Y202	15.9849	3.86	Yes	Yes	1	9	4
10	R:R:I189	R:R:L201	11.2967	4.28	No	Yes	1	3	1
11	L:L:?1	R:R:E293	19.3472	5.69	Yes	Yes	1	0	4
12	R:R:L105	R:R:Y102	11.9333	3.52	No	Yes	0	6	7
13	L:L:?1	R:R:T109	14.3882	8.44	Yes	No	0	0	5
14	R:R:G110	R:R:T109	12.9005	3.64	No	No	0	5	5
15	R:R:L298	R:R:Y102	19.5196	3.52	Yes	Yes	0	6	7
16	R:R:L298	R:R:V59	16.4773	4.47	Yes	No	0	6	7
17	R:R:I63	R:R:V59	15.883	3.07	Yes	No	0	8	7
18	R:R:C60	R:R:Y102	14.2581	5.38	No	Yes	0	6	7
19	R:R:I63	R:R:S304	15.7247	4.64	Yes	No	0	8	9
20	L:L:?1	R:R:W210	100	23.63	Yes	Yes	1	0	6
21	R:R:W210	R:R:W271	72.0853	3.75	Yes	Yes	1	6	8
22	R:R:N303	R:R:W271	85.3726	6.78	No	Yes	0	9	8
23	R:R:N303	R:R:N307	83.5438	10.9	No	No	0	9	9
24	R:R:D95	R:R:N307	20.9862	8.08	Yes	No	0	9	9
25	R:R:D95	R:R:S304	19.6919	11.78	Yes	No	0	9	9
26	R:R:L139	R:R:N307	62.4134	9.61	No	No	0	8	9
27	R:R:L139	R:R:Y311	54.7392	4.69	No	Yes	2	8	9
28	R:R:M88	R:R:Y311	52.4461	3.59	No	Yes	2	8	9
29	R:R:I84	R:R:M88	52.6008	2.92	No	No	0	8	8
30	R:R:I84	R:R:Y85	38.1106	3.63	No	Yes	0	8	9
31	R:R:F80	R:R:Y85	19.6708	13.41	Yes	Yes	4	8	9
32	R:R:D315	R:R:Y85	13.9486	6.9	No	Yes	0	8	9
33	R:R:E145	R:R:I84	16.5266	4.1	Yes	No	0	8	8
34	R:R:D95	R:R:L91	20.4305	4.07	Yes	Yes	0	9	9
35	R:R:L91	R:R:N138	16.4879	5.49	Yes	No	0	9	8
36	R:R:N138	R:R:N90	11.0541	12.26	No	No	0	8	9
37	R:R:A98	R:R:S304	15.4328	3.42	No	No	0	8	9
38	R:R:A98	R:R:S131	14.0646	3.42	No	No	0	8	6
39	R:R:F97	R:R:S131	11.3073	5.28	No	No	0	7	6
40	R:R:E301	R:R:Y102	11.0576	16.83	No	Yes	0	7	7
41	R:R:L132	R:R:W271	11.972	5.69	No	Yes	0	7	8
42	R:R:N214	R:R:W210	47.9162	14.69	Yes	Yes	1	7	6
43	R:R:F213	R:R:N214	22.5091	7.25	No	Yes	1	5	7
44	R:R:N214	R:R:V136	24.8233	4.43	Yes	Yes	1	7	8
45	R:R:V136	R:R:W271	53.241	4.9	Yes	Yes	1	8	8
46	R:R:T217	R:R:V136	74.9341	4.76	No	Yes	1	7	8
47	R:R:F213	R:R:T217	22.1609	5.19	No	No	1	5	7
48	R:R:F267	R:R:W271	10.3295	11.02	No	Yes	1	9	8
49	R:R:L140	R:R:T217	95.5087	5.9	No	No	0	7	7
50	R:R:I144	R:R:L140	79.2248	2.85	Yes	No	0	6	7
51	R:R:I144	R:R:L224	62.4697	2.85	Yes	No	0	6	6
52	R:R:H147	R:R:L224	60.7322	9	Yes	No	0	7	6
53	R:R:F151	R:R:H147	53.5047	13.58	Yes	Yes	6	6	7
54	R:R:I144	R:R:I148	15.4082	1.47	Yes	No	0	6	5
55	R:R:I148	R:R:R152	13.4878	5.01	No	No	0	5	5
56	R:R:M159	R:R:R152	11.5605	2.48	No	No	0	6	5
57	R:R:M178	R:R:W210	15.5735	3.49	Yes	Yes	1	5	6
58	R:R:W186	R:R:Y206	13.9662	4.82	Yes	Yes	0	6	7
59	R:R:L140	R:R:V220	17.4691	2.98	No	No	0	7	5
60	R:R:V216	R:R:V220	15.5559	1.6	No	No	0	4	5
61	R:R:I212	R:R:V216	13.6356	1.54	No	No	0	4	4
62	R:R:I212	R:R:V208	11.7082	1.54	No	No	0	4	4
63	R:R:E293	R:R:M198	17.5008	4.06	Yes	No	0	4	3
64	R:R:F218	R:R:F267	12.6754	10.72	No	No	0	5	9
65	R:R:F151	R:R:Y231	50.1424	12.38	Yes	No	0	6	6
66	R:R:V232	R:R:Y231	43.0978	1.26	Yes	No	0	7	6
67	R:R:M253	R:R:V232	18.992	3.04	Yes	Yes	0	7	7
68	R:R:F229	R:R:M253	11.564	3.73	Yes	Yes	0	6	7
69	R:R:L256	R:R:V232	13.2487	4.47	No	Yes	0	7	7
70	R:R:F229	R:R:L256	11.4972	6.09	Yes	No	0	6	7
71	R:R:F229	R:R:G230	11.5605	1.51	Yes	No	0	6	2
72	R:R:E301	R:R:L132	11.047	5.3	No	No	0	7	7
73	R:R:M178	R:R:Y206	13.1678	4.79	Yes	Yes	1	5	7
74	R:R:L91	R:R:Y311	14.0295	3.52	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y34	4.19	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	8.07	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L105	4.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:T109	8.44	1	Yes	No	0	5	0	1
L:L:?1	R:R:T113	6.33	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	6.95	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	7.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	9.71	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y202	3.36	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W210	23.63	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	5.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	5.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	7.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	6.93	1	Yes	No	0	6	0	1
R:R:I30	R:R:Y34	3.63	1	No	Yes	6	6	2	1
R:R:I30	R:R:W121	5.87	1	No	Yes	6	9	2	2
R:R:K39	R:R:Y34	11.94	1	Yes	Yes	8	6	1	1
R:R:L41	R:R:Y34	4.69	0	No	Yes	2	6	2	1
R:R:W121	R:R:Y34	9.65	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	18.08	1	No	Yes	6	6	2	1
R:R:K39	R:R:P200	3.35	1	Yes	No	8	6	1	2
R:R:K39	R:R:L290	4.23	1	Yes	No	8	3	1	2
R:R:E293	R:R:K39	10.8	1	Yes	Yes	4	8	1	1
R:R:K294	R:R:V52	3.04	0	No	No	4	5	1	2
R:R:L105	R:R:Y102	3.52	1	No	Yes	6	7	1	2
R:R:L297	R:R:Y102	3.52	0	No	Yes	6	7	1	2
R:R:L105	R:R:Q125	3.99	1	No	Yes	6	4	1	1
R:R:G110	R:R:T109	3.64	0	No	No	5	5	2	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:Q125	R:R:W121	9.86	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	3.86	1	Yes	Yes	9	4	2	1
R:R:Q125	R:R:R124	14.02	1	Yes	Yes	4	6	1	1
R:R:I128	R:R:Q125	4.12	0	No	Yes	6	4	2	1
R:R:Q125	R:R:Y202	4.51	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:Y202	6.9	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	8.05	1	Yes	Yes	5	7	1	2
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	7.28	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	4.79	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	11.13	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	13.91	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	4.06	1	Yes	No	4	3	1	2
R:R:A199	R:R:Y202	4	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	3.97	1	Yes	Yes	4	7	1	2
R:R:N214	R:R:W210	14.69	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	3.75	1	Yes	Yes	6	8	1	2
R:R:E293	R:R:L290	5.3	1	Yes	No	4	3	1	2
R:R:D129	R:R:G126	1.68	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	276
Number of Links	316
Number of Hubs	40
Number of Links mediated by Hubs	160
Number of Communities	9
Number of Nodes involved in Communities	57
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	68981
Length Of Smallest Path	3
Average Path Length	13.1599
Length of Longest Path	27
Minimum Path Strength	1.36
Average Path Strength	6.67125
Maximum Path Strength	19.16
Minimum Path Correlation	0.7
Average Path Correlation	0.926676
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.0657
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3712
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • fibroblast proliferation • cell population proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • regulation of metabolic process • cell chemotaxis • chemotaxis • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • protein-containing complex localization • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • periplasmic space • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • glutamatergic synapse • somatodendritic compartment • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • heterocyclic compound binding • ribonucleotide binding
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9IZG_nogp_Chain_R S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R H S S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Q I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	10.1016/j.jsb.2024.108164
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	10.1038/s41467-022-33121-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	10.1038/s41467-022-28417-2
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	10.1016/j.cell.2015.06.002

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IZG_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.