psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q125	7.59	Yes	Yes	1	0	4
2	L:L:?1	R:R:I128	8.13	Yes	No	0	0	6
3	L:L:?1	R:R:D129	14.36	Yes	Yes	1	0	5
4	L:L:?1	R:R:M198	8.06	Yes	No	1	0	3
5	L:L:?1	R:R:Y202	3.82	Yes	Yes	1	0	4
6	L:L:?1	R:R:W210	12.05	Yes	Yes	1	0	6
7	L:L:?1	R:R:W271	3.71	Yes	Yes	1	0	8
8	L:L:?1	R:R:L278	15.78	Yes	No	0	0	6
9	L:L:?1	R:R:E293	6.47	Yes	Yes	1	0	4
10	L:L:?1	R:R:L297	12.4	Yes	No	0	0	6
11	R:R:F25	R:R:Q23	8.2	No	No	0	7	3
12	R:R:C190	R:R:C24	7.28	No	No	0	3	5
13	R:R:F25	R:R:F32	10.72	No	No	0	7	2
14	R:R:F25	R:R:I192	7.54	No	No	0	7	1
15	R:R:E28	R:R:N27	6.57	No	No	0	4	8
16	R:R:E28	R:R:F32	20.99	No	No	0	4	2
17	R:R:F33	R:R:L201	23.14	No	No	0	6	1
18	R:R:K39	R:R:Y34	8.36	No	Yes	0	8	6
19	R:R:T113	R:R:Y34	4.99	No	Yes	0	5	6
20	R:R:P200	R:R:Y34	9.74	No	Yes	0	6	6
21	R:R:I192	R:R:R36	7.52	No	No	0	1	3
22	R:R:E193	R:R:R36	12.79	No	No	0	4	3
23	R:R:K39	R:R:L290	5.64	No	No	1	8	3
24	R:R:E293	R:R:K39	9.45	Yes	No	1	4	8
25	R:R:L41	R:R:R114	12.15	No	No	0	2	6
26	R:R:R114	R:R:T43	10.35	No	No	0	6	3
27	R:R:M53	R:R:W45	4.65	No	Yes	0	4	1
28	R:R:P111	R:R:W45	21.62	No	Yes	4	4	1
29	R:R:N112	R:R:W45	6.78	No	Yes	4	4	1
30	R:R:N46	R:R:S49	8.94	No	No	0	2	1
31	R:R:K50	R:R:M53	11.52	No	No	0	3	4
32	R:R:G54	R:R:K50	3.49	No	No	0	4	3
33	R:R:K294	R:R:V52	12.14	No	No	0	4	5
34	R:R:F295	R:R:V52	3.93	No	No	0	4	5
35	R:R:G56	R:R:L298	3.42	No	Yes	0	6	6
36	R:R:F103	R:R:I57	5.02	Yes	No	5	6	4
37	R:R:F107	R:R:I57	3.77	No	No	5	5	4
38	R:R:L298	R:R:V59	4.47	Yes	No	0	6	7
39	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
40	R:R:C60	R:R:F103	5.59	No	Yes	0	6	6
41	R:R:I63	R:R:N67	4.25	Yes	Yes	0	8	9
42	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
43	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
44	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
45	R:R:F96	R:R:M64	4.98	No	No	0	7	6
46	R:R:F103	R:R:M64	4.98	Yes	No	0	6	6
47	R:R:A66	R:R:P308	3.74	No	No	0	8	9
48	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
49	R:R:D95	R:R:N67	8.08	Yes	Yes	0	9	9
50	R:R:F96	R:R:N67	3.62	No	Yes	0	7	9
51	R:R:N67	R:R:P308	4.89	Yes	No	0	9	9
52	R:R:L68	R:R:V72	4.47	No	No	0	4	5
53	R:R:A92	R:R:V70	3.39	No	No	0	9	9
54	R:R:F322	R:R:V70	3.93	No	No	0	6	9
55	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
56	R:R:A73	R:R:F322	4.16	No	No	0	7	6
57	R:R:I74	R:R:Y85	4.84	No	Yes	0	7	9
58	R:R:A89	R:R:I74	4.87	No	No	0	7	7
59	R:R:I74	R:R:M318	5.83	No	Yes	0	7	8
60	R:R:N77	R:R:V76	5.91	Yes	No	0	6	5
61	R:R:N77	R:R:R79	13.26	Yes	No	3	6	6
62	R:R:F80	R:R:N77	8.46	Yes	Yes	3	8	6
63	R:R:N77	R:R:T321	8.77	Yes	No	0	6	7
64	R:R:H81	R:R:R78	9.03	No	No	0	8	6
65	R:R:F80	R:R:R79	9.62	Yes	No	3	8	6
66	R:R:E317	R:R:R79	13.96	No	No	3	7	6
67	R:R:F80	R:R:Y85	19.6	Yes	Yes	0	8	9
68	R:R:E317	R:R:F80	5.83	No	Yes	3	7	8
69	R:R:F80	R:R:M318	13.68	Yes	Yes	0	8	8
70	R:R:H81	R:R:Y86	8.71	No	No	0	8	4
71	R:R:E145	R:R:P83	4.72	Yes	Yes	0	8	6
72	R:R:M159	R:R:P83	8.39	No	Yes	0	6	6
73	R:R:N161	R:R:P83	3.26	No	Yes	0	3	6
74	R:R:P83	R:R:V164	5.3	Yes	No	0	6	7
75	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
76	R:R:E145	R:R:I84	8.2	Yes	No	0	8	8
77	R:R:D315	R:R:Y85	4.6	No	Yes	0	8	9
78	R:R:N161	R:R:Y86	8.14	No	No	0	3	4
79	R:R:V164	R:R:Y86	3.79	No	No	0	7	4
80	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
81	R:R:M88	R:R:Y311	3.59	No	Yes	0	8	9
82	R:R:N138	R:R:N90	13.62	No	No	0	8	9
83	R:R:I168	R:R:N90	11.33	No	No	0	8	9
84	R:R:N90	R:R:W172	9.04	No	No	0	9	9
85	R:R:D95	R:R:L91	5.43	Yes	No	0	9	9
86	R:R:L91	R:R:N138	6.87	No	No	0	9	8
87	R:R:L139	R:R:L91	5.54	No	No	0	8	9
88	R:R:A94	R:R:S135	3.42	No	No	0	8	9
89	R:R:D95	R:R:S135	4.42	Yes	No	0	9	9
90	R:R:D95	R:R:S304	7.36	Yes	No	0	9	9
91	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
92	R:R:F97	R:R:T130	3.89	Yes	No	0	7	6
93	R:R:F97	R:R:S131	3.96	Yes	Yes	0	7	6
94	R:R:F97	R:R:W172	4.01	Yes	No	0	7	9
95	R:R:A98	R:R:S131	3.42	No	Yes	0	8	6
96	R:R:A101	R:R:I128	3.25	No	No	0	5	6
97	R:R:A101	R:R:S131	3.42	No	Yes	0	5	6
98	R:R:L297	R:R:Y102	10.55	No	Yes	0	6	7
99	R:R:L298	R:R:Y102	7.03	Yes	Yes	0	6	7
100	R:R:E301	R:R:Y102	21.32	No	Yes	0	7	7
101	R:R:F103	R:R:F107	13.93	Yes	No	5	6	5
102	R:R:N108	R:R:Y104	6.98	No	No	0	5	5
103	R:R:L105	R:R:R124	12.15	No	Yes	0	6	6
104	R:R:I128	R:R:L105	5.71	No	No	0	6	6
105	R:R:F107	R:R:M106	3.73	No	No	0	5	6
106	R:R:K294	R:R:M106	7.2	No	No	0	4	6
107	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
108	R:R:K294	R:R:T109	4.5	No	No	0	4	5
109	R:R:G110	R:R:P111	4.06	No	No	0	5	4
110	R:R:N112	R:R:P111	8.15	No	No	4	4	4
111	R:R:R115	R:R:T120	3.88	No	Yes	0	3	4
112	R:R:L116	R:R:W121	5.69	No	Yes	1	6	9
113	R:R:L116	R:R:R124	4.86	No	Yes	1	6	6
114	R:R:T117	R:R:T120	4.71	No	Yes	1	6	4
115	R:R:R124	R:R:W121	10	Yes	Yes	1	6	9
116	R:R:Q125	R:R:W121	26.29	Yes	Yes	1	4	9
117	R:R:W121	R:R:Y202	3.86	Yes	Yes	1	9	4
118	R:R:Q125	R:R:R124	8.18	Yes	Yes	1	4	6
119	R:R:Q125	R:R:Y202	7.89	Yes	Yes	1	4	4
120	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
121	R:R:D129	R:R:Y202	9.2	Yes	Yes	1	5	4
122	R:R:D129	R:R:Y206	9.2	Yes	Yes	1	5	7
123	R:R:L132	R:R:S131	4.5	Yes	Yes	0	7	6
124	R:R:L132	R:R:W210	4.56	Yes	Yes	1	7	6
125	R:R:L132	R:R:W271	5.69	Yes	Yes	1	7	8
126	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
127	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
128	R:R:T133	R:R:W210	7.28	No	Yes	1	6	6
129	R:R:F213	R:R:T133	3.89	No	No	0	5	6
130	R:R:A134	R:R:W172	3.89	No	No	0	7	9
131	R:R:T217	R:R:V136	4.76	Yes	No	0	7	8
132	R:R:F267	R:R:V136	5.24	Yes	No	1	9	8
133	R:R:V136	R:R:W271	3.68	No	Yes	1	8	8
134	R:R:A137	R:R:I171	4.87	No	No	0	5	7
135	R:R:I171	R:R:N138	8.5	No	No	0	7	8
136	R:R:L139	R:R:N307	8.24	No	No	0	8	9
137	R:R:L140	R:R:T217	7.37	Yes	Yes	0	7	7
138	R:R:A141	R:R:I171	3.25	No	No	0	8	7
139	R:R:I142	R:R:R146	6.26	No	No	2	8	9
140	R:R:I142	R:R:Y311	9.67	No	Yes	2	8	9
141	R:R:R146	R:R:Y225	9.26	No	Yes	2	9	9
142	R:R:R146	R:R:Y311	12.35	No	Yes	2	9	9
143	R:R:F151	R:R:H147	22.63	Yes	Yes	6	6	7
144	R:R:H147	R:R:L224	7.71	Yes	No	0	7	6
145	R:R:H147	R:R:H227	10.75	Yes	No	6	7	5
146	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
147	R:R:R152	R:R:T149	7.76	No	No	0	5	8
148	R:R:F151	R:R:V150	5.24	Yes	No	0	6	8
149	R:R:I228	R:R:V150	9.22	No	No	0	9	8
150	R:R:F151	R:R:H227	13.58	Yes	No	6	6	5
151	R:R:F151	R:R:Y231	11.35	Yes	No	0	6	6
152	R:R:R152	R:R:T157	10.35	No	No	0	5	4
153	R:R:M153	R:R:R235	4.96	No	No	0	7	7
154	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
155	R:R:H156	R:R:L155	10.29	No	No	0	4	8
156	R:R:F213	R:R:M174	3.73	No	No	0	5	4
157	R:R:M178	R:R:Y206	5.99	Yes	Yes	1	5	7
158	R:R:F209	R:R:M178	3.73	No	Yes	0	6	5
159	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
160	R:R:I181	R:R:P182	3.39	No	No	0	5	6
161	R:R:I181	R:R:W186	3.52	No	No	0	5	6
162	R:R:P182	R:R:Y202	12.52	No	Yes	1	6	4
163	R:R:P182	R:R:Y206	16.69	No	Yes	1	6	7
164	R:R:G185	R:R:V184	3.68	No	No	0	5	5
165	R:R:S205	R:R:W186	11.12	No	No	0	5	6
166	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
167	R:R:I189	R:R:N187	5.66	Yes	No	0	3	6
168	R:R:C188	R:R:C195	7.28	No	No	7	5	9
169	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
170	R:R:L207	R:R:S196	4.5	No	No	0	6	5
171	R:R:D281	R:R:S196	8.83	No	No	0	4	5
172	R:R:D281	R:R:N197	14.81	No	No	0	4	5
173	R:R:D281	R:R:M198	5.54	No	No	0	4	3
174	R:R:E293	R:R:M198	18.95	Yes	No	1	4	3
175	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
176	R:R:Y202	R:R:Y206	11.91	Yes	Yes	1	4	7
177	R:R:S203	R:R:S205	4.89	No	No	0	5	5
178	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
179	R:R:L207	R:R:V282	4.47	No	Yes	0	6	5
180	R:R:V208	R:R:V282	4.81	No	Yes	0	4	5
181	R:R:W210	R:R:W271	3.75	Yes	Yes	1	6	8
182	R:R:F213	R:R:T217	6.49	No	Yes	0	5	7
183	R:R:F267	R:R:N214	4.83	Yes	No	1	9	7
184	R:R:N214	R:R:W271	6.78	No	Yes	1	7	8
185	R:R:L275	R:R:N214	10.98	No	No	1	6	7
186	R:R:F218	R:R:V222	6.55	No	No	0	5	4
187	R:R:F218	R:R:F267	12.86	No	Yes	0	5	9
188	R:R:F218	R:R:I268	5.02	No	No	0	5	6
189	R:R:L264	R:R:V222	5.96	No	No	0	7	4
190	R:R:V260	R:R:Y225	5.05	No	Yes	0	8	9
191	R:R:V263	R:R:Y225	3.79	No	Yes	2	8	9
192	R:R:L264	R:R:Y225	4.69	No	Yes	0	7	9
193	R:R:Y225	R:R:Y311	4.96	Yes	Yes	2	9	9
194	R:R:F229	R:R:M253	7.46	Yes	No	0	6	7
195	R:R:F229	R:R:L256	9.74	Yes	No	0	6	7
196	R:R:F229	R:R:L257	10.96	Yes	No	0	6	7
197	R:R:R235	R:R:Y231	11.32	No	No	0	7	6
198	R:R:L256	R:R:V232	4.47	No	No	0	7	7
199	R:R:M253	R:R:R233	4.96	No	No	0	7	5
200	R:R:D251	R:R:M253	4.16	No	No	0	5	7
201	R:R:R314	R:R:S255	6.59	No	No	0	7	7
202	R:R:T259	R:R:Y313	4.99	No	No	0	8	5
203	R:R:I262	R:R:I310	4.42	No	No	0	6	8
204	R:R:I262	R:R:Y313	3.63	No	No	0	6	5
205	R:R:V263	R:R:Y311	7.57	No	Yes	2	8	9
206	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
207	R:R:I268	R:R:T272	4.56	No	No	0	6	5
208	R:R:C270	R:R:I269	3.27	No	No	0	9	5
209	R:R:C270	R:R:L299	4.76	No	No	0	9	7
210	R:R:C270	R:R:N303	7.87	No	No	0	9	9
211	R:R:L275	R:R:W271	5.69	No	Yes	1	6	8
212	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
213	R:R:N303	R:R:W271	10.17	No	Yes	0	9	8
214	R:R:P273	R:R:T272	5.25	No	No	0	9	5
215	R:R:F296	R:R:P273	8.67	Yes	No	0	5	9
216	R:R:L277	R:R:V289	4.47	No	No	0	4	4
217	R:R:F296	R:R:L277	8.53	Yes	No	0	5	4
218	R:R:C283	R:R:V282	3.42	No	Yes	0	4	5
219	R:R:C284	R:R:P285	3.77	No	No	0	4	3
220	R:R:C284	R:R:C287	7.28	No	No	0	4	5
221	R:R:E293	R:R:L290	3.98	Yes	No	1	4	3
222	R:R:F302	R:R:M306	12.44	No	No	0	5	6
223	R:R:N303	R:R:N307	4.09	No	No	0	9	9
224	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
225	R:R:F322	R:R:S312	5.28	No	No	0	6	7
226	R:R:D315	R:R:M318	4.16	No	Yes	0	8	8
227	R:R:R314	R:R:Y313	3.09	No	No	0	7	5
228	R:R:I189	R:R:V118	3.07	Yes	No	0	3	2
229	R:R:I181	R:R:V177	3.07	No	No	0	5	4
230	R:R:I212	R:R:V208	3.07	No	No	0	4	4
231	R:R:I176	R:R:T130	3.04	No	No	0	3	6
232	R:R:F296	R:R:G274	3.01	Yes	No	0	5	5
233	R:R:L140	R:R:V220	2.98	Yes	No	0	7	5
234	R:R:L280	R:R:V289	2.98	No	No	0	5	4
235	R:R:L116	R:R:T120	2.95	No	Yes	1	6	4
236	R:R:I309	R:R:I310	2.94	No	No	0	7	8
237	R:R:A42	R:R:H40	2.93	No	No	0	4	2
238	R:R:M106	R:R:M53	2.89	No	No	0	6	4
239	R:R:F82	R:R:P83	2.89	No	Yes	0	7	6
240	R:R:K258	R:R:M254	2.88	No	No	0	7	5
241	R:R:I61	R:R:L65	2.85	No	No	0	4	4
242	R:R:I144	R:R:L140	2.85	No	Yes	0	6	7
243	R:R:I144	R:R:L224	2.85	No	No	0	6	6
244	R:R:L139	R:R:M221	2.83	No	No	0	8	9
245	R:R:L140	R:R:M221	2.83	Yes	No	0	7	9
246	R:R:L298	R:R:L55	2.77	Yes	No	0	6	4
247	R:R:A305	R:R:F62	2.77	No	No	0	7	4
248	R:R:A305	R:R:F302	2.77	No	No	0	7	5
249	R:R:A143	R:R:Y225	2.67	No	Yes	0	8	9
250	R:R:R162	R:R:V165	2.62	No	No	0	5	1
251	R:R:M237	R:R:R233	2.48	No	No	0	5	5
252	R:R:F96	R:R:L100	2.44	No	No	0	7	4
253	R:R:F97	R:R:L127	2.44	Yes	No	0	7	5
254	R:R:I30	R:R:Y34	2.42	No	Yes	0	6	6
255	R:R:L122	R:R:Y202	2.34	No	Yes	0	5	4
256	R:R:F32	R:R:F33	2.14	No	No	0	2	6
257	R:R:G126	R:R:G179	2.11	No	No	0	6	7
258	R:R:F296	R:R:Y292	2.06	Yes	No	0	5	3
259	R:R:A42	R:R:G110	1.95	No	No	0	4	5
260	R:R:A134	R:R:A175	1.79	No	No	0	7	8
261	R:R:P200	R:R:S37	1.78	No	No	0	6	7
262	R:R:G265	R:R:I268	1.76	No	No	0	4	6
263	R:R:C188	R:R:S203	1.72	No	No	7	5	5
264	R:R:C195	R:R:S203	1.72	No	No	7	9	5
265	R:R:A31	R:R:S29	1.71	No	No	0	2	4
266	R:R:C287	R:R:V289	1.71	No	No	0	5	4
267	R:R:G185	R:R:N187	1.7	No	No	0	5	6
268	R:R:L201	R:R:P200	1.64	No	No	0	1	6
269	R:R:S49	R:R:V48	1.62	No	No	0	1	3
270	R:R:A266	R:R:M306	1.61	No	No	0	6	6
271	R:R:S119	R:R:T117	1.6	No	No	1	1	6
272	R:R:S119	R:R:T120	1.6	No	Yes	1	1	4
273	R:R:V150	R:R:V232	1.6	No	No	0	8	7
274	R:R:V164	R:R:V165	1.6	No	No	0	7	1
275	R:R:V166	R:R:V170	1.6	No	No	0	3	3
276	R:R:V169	R:R:V170	1.6	No	No	0	4	3
277	R:R:V219	R:R:V220	1.6	No	No	0	3	5
278	R:R:T217	R:R:V216	1.59	Yes	No	0	7	4
279	R:R:T236	R:R:V232	1.59	No	No	0	5	7
280	R:R:T272	R:R:V276	1.59	No	No	0	5	6
281	R:R:C283	R:R:L279	1.59	No	No	0	4	6
282	R:R:A211	R:R:L279	1.58	No	No	0	4	6
283	R:R:T236	R:R:T252	1.57	No	No	0	5	5
284	R:R:A31	R:R:N35	1.56	No	No	0	2	7
285	R:R:A42	R:R:N46	1.56	No	No	0	4	2
286	R:R:A291	R:R:D288	1.54	No	No	0	2	1
287	R:R:I57	R:R:T58	1.52	No	No	0	4	5
288	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
289	R:R:L87	R:R:V167	1.49	No	No	0	8	6
290	R:R:L224	R:R:V223	1.49	No	No	0	6	4
291	R:R:L257	R:R:V261	1.49	No	No	0	7	5
292	R:R:L41	R:R:T113	1.47	No	No	0	2	5
293	R:R:E145	R:R:T149	1.41	Yes	No	0	8	8
294	R:R:D251	R:R:M254	1.39	No	No	0	5	5
295	R:R:L65	R:R:L69	1.38	No	No	0	4	7
296	R:R:L123	R:R:L127	1.38	No	No	0	4	5
297	R:R:R162	R:R:S160	1.32	No	No	0	5	8
298	R:R:E193	R:R:N194	1.31	No	No	0	4	3
299	R:R:I189	R:R:Y26	1.21	Yes	No	0	3	4
300	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
301	R:R:E44	R:R:W45	1.09	No	Yes	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.237	10	1	0
2	R:R:Y34	5.334	5	0	6
3	R:R:W45	8.535	4	4	1
4	R:R:I63	4.3575	4	0	8
5	R:R:N67	5.106	5	0	9
6	R:R:N77	9.1	4	3	6
7	R:R:F80	11.438	5	3	8
8	R:R:P83	4.912	5	0	6
9	R:R:Y85	8.1675	4	0	9
10	R:R:D95	6.674	5	0	9
11	R:R:F97	3.575	4	0	7
12	R:R:Y102	11.07	4	0	7
13	R:R:F103	7.38	4	5	6
14	R:R:T120	3.285	4	1	4
15	R:R:W121	11.46	4	1	9
16	R:R:R124	8.484	5	1	6
17	R:R:Q125	12.4875	4	1	4
18	R:R:D129	9.4475	4	1	5
19	R:R:S131	3.825	4	0	6
20	R:R:L132	5.345	4	1	7
21	R:R:L140	4.0075	4	0	7
22	R:R:E145	4.9075	4	0	8
23	R:R:H147	11.5975	4	6	7
24	R:R:F151	13.2	4	6	6
25	R:R:M178	5.185	4	1	5
26	R:R:I189	3.555	4	0	3
27	R:R:Y202	6.9425	8	1	4
28	R:R:Y206	9.53	5	1	7
29	R:R:W210	6.226	5	1	6
30	R:R:T217	5.0525	4	0	7
31	R:R:Y225	5.07	6	2	9
32	R:R:F229	7.4175	4	0	6
33	R:R:F267	9.7425	4	1	9
34	R:R:W271	6.6	9	1	8
35	R:R:V282	5.365	4	0	5
36	R:R:E293	9.7125	4	1	4
37	R:R:F296	5.5675	4	0	5
38	R:R:L298	4.4225	4	0	6
39	R:R:Y311	6.96167	6	2	9
40	R:R:M318	6.7225	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E293	36.2977	6.47	Yes	Yes	1	0	4
2	R:R:E293	R:R:K39	35.3784	9.45	Yes	No	1	4	8
3	R:R:K39	R:R:Y34	34.424	8.36	No	Yes	0	8	6
4	R:R:P200	R:R:Y34	24.02	9.74	No	Yes	0	6	6
5	R:R:L201	R:R:P200	21.611	1.64	No	No	0	1	6
6	R:R:F33	R:R:L201	12.9574	23.14	No	No	0	6	1
7	R:R:F32	R:R:F33	11.693	2.14	No	No	0	2	6
8	L:L:?1	R:R:L297	20.8396	12.4	Yes	No	0	0	6
9	R:R:L297	R:R:Y102	20.1282	10.55	No	Yes	0	6	7
10	R:R:C60	R:R:Y102	27.7709	5.38	No	Yes	0	6	7
11	R:R:C60	R:R:F103	27.1616	5.59	No	Yes	0	6	6
12	R:R:F103	R:R:F107	33.3533	13.93	Yes	No	5	6	5
13	R:R:F107	R:R:M106	31.941	3.73	No	No	0	5	6
14	R:R:M106	R:R:M53	23.3896	2.89	No	No	0	6	4
15	R:R:M53	R:R:W45	18.096	4.65	No	Yes	0	4	1
16	R:R:P111	R:R:W45	12.7179	21.62	No	Yes	4	4	1
17	R:R:G110	R:R:P111	10.9428	4.06	No	No	0	5	4
18	L:L:?1	R:R:W271	75.8743	3.71	Yes	Yes	1	0	8
19	R:R:N303	R:R:W271	66.6678	10.17	No	Yes	0	9	8
20	R:R:N303	R:R:N307	65.7099	4.09	No	No	0	9	9
21	R:R:D95	R:R:N307	83.3269	8.08	Yes	No	0	9	9
22	R:R:D95	R:R:N67	100	8.08	Yes	Yes	0	9	9
23	R:R:I63	R:R:N67	10.0764	4.25	Yes	Yes	0	8	9
24	R:R:A305	R:R:I63	11.7423	3.25	No	Yes	0	7	8
25	R:R:F96	R:R:N67	21.6884	3.62	No	Yes	0	7	9
26	R:R:F103	R:R:M64	19.8922	4.98	Yes	No	0	6	6
27	R:R:F96	R:R:M64	19.9908	4.98	No	No	0	7	6
28	R:R:A92	R:R:N67	92.6778	4.69	No	Yes	0	9	9
29	R:R:A92	R:R:V70	91.8536	3.39	No	No	0	9	9
30	R:R:F322	R:R:V70	91.0224	3.93	No	No	0	6	9
31	R:R:A73	R:R:F322	89.3389	4.16	No	No	0	7	6
32	R:R:A73	R:R:M318	88.4866	3.22	No	Yes	0	7	8
33	R:R:I74	R:R:M318	28.1337	5.83	No	Yes	0	7	8
34	R:R:I74	R:R:Y85	26.024	4.84	No	Yes	0	7	9
35	R:R:F80	R:R:M318	32.6912	13.68	Yes	Yes	0	8	8
36	R:R:F80	R:R:Y85	26.3269	19.6	Yes	Yes	0	8	9
37	R:R:D315	R:R:M318	26.894	4.16	No	Yes	0	8	8
38	R:R:D315	R:R:Y85	25.8162	4.6	No	Yes	0	8	9
39	R:R:I84	R:R:Y85	74.779	3.63	No	Yes	0	8	9
40	R:R:E145	R:R:I84	71.3944	8.2	Yes	No	0	8	8
41	R:R:E145	R:R:P83	48.033	4.72	Yes	Yes	0	8	6
42	R:R:N161	R:R:P83	13.6407	3.26	No	Yes	0	3	6
43	R:R:N161	R:R:Y86	10.4744	8.14	No	No	0	3	4
44	R:R:H81	R:R:Y86	13.9858	8.71	No	No	0	8	4
45	R:R:P83	R:R:V164	24.418	5.3	Yes	No	0	6	7
46	R:R:V164	R:R:Y86	10.5096	3.79	No	No	0	7	4
47	R:R:F267	R:R:W271	35.7694	16.04	Yes	Yes	1	9	8
48	R:R:F218	R:R:F267	40.7037	12.86	No	Yes	0	5	9
49	R:R:F218	R:R:V222	23.0057	6.55	No	No	0	5	4
50	R:R:L264	R:R:V222	21.7695	5.96	No	No	0	7	4
51	R:R:L264	R:R:Y225	20.5015	4.69	No	Yes	0	7	9
52	R:R:Y225	R:R:Y311	12.8412	4.96	Yes	Yes	2	9	9
53	R:R:D95	R:R:L91	30.6871	5.43	Yes	No	0	9	9
54	R:R:L91	R:R:N138	11.5099	6.87	No	No	0	9	8
55	R:R:L139	R:R:N307	26.1367	8.24	No	No	0	8	9
56	R:R:L139	R:R:L91	26.1755	5.54	No	No	0	8	9
57	R:R:F97	R:R:S131	10.9217	3.96	Yes	Yes	0	7	6
58	R:R:L132	R:R:S131	11.6226	4.5	Yes	Yes	0	7	6
59	R:R:L132	R:R:W271	17.7579	5.69	Yes	Yes	1	7	8
60	R:R:E301	R:R:L132	12.3199	6.63	No	Yes	0	7	7
61	R:R:E301	R:R:Y102	11.6613	21.32	No	Yes	0	7	7
62	L:L:?1	R:R:Q125	15.5461	7.59	Yes	Yes	1	0	4
63	R:R:L116	R:R:W121	10.7738	5.69	No	Yes	1	6	9
64	R:R:L116	R:R:T120	13.1124	2.95	No	Yes	1	6	4
65	L:L:?1	R:R:Y202	18.089	3.82	Yes	Yes	1	0	4
66	R:R:V136	R:R:W271	27.0489	3.68	No	Yes	1	8	8
67	R:R:T217	R:R:V136	32.0466	4.76	Yes	No	0	7	8
68	R:R:L140	R:R:T217	34.9276	7.37	Yes	Yes	0	7	7
69	R:R:I144	R:R:L140	67.8266	2.85	No	Yes	0	6	7
70	R:R:I144	R:R:L224	66.2417	2.85	No	No	0	6	6
71	R:R:H147	R:R:L224	63.0226	7.71	Yes	No	0	7	6
72	R:R:F151	R:R:H147	32.3707	22.63	Yes	Yes	6	6	7
73	R:R:H147	R:R:I228	27.3272	5.3	Yes	No	0	7	9
74	R:R:E145	R:R:T149	13.7217	1.41	Yes	No	0	8	8
75	R:R:R152	R:R:T149	10.2208	7.76	No	No	0	5	8
76	R:R:F151	R:R:V150	25.8338	5.24	Yes	No	0	6	8
77	R:R:I228	R:R:V150	25.788	9.22	No	No	0	9	8
78	R:R:W186	R:R:Y206	13.5033	3.86	No	Yes	0	6	7
79	R:R:S205	R:R:W186	10.4638	11.12	No	No	0	5	6
80	L:L:?1	R:R:M198	14.0457	8.06	Yes	No	1	0	3
81	R:R:D281	R:R:M198	14.2148	5.54	No	No	0	4	3
82	R:R:D281	R:R:S196	11.693	8.83	No	No	0	4	5
83	R:R:L207	R:R:S196	10.4216	4.5	No	No	0	6	5
84	R:R:F218	R:R:I268	18.339	5.02	No	No	0	5	6
85	R:R:V150	R:R:V232	48.1562	1.6	No	No	0	8	7
86	R:R:L256	R:R:V232	38.2594	4.47	No	No	0	7	7
87	R:R:F229	R:R:L256	35.1002	9.74	Yes	No	0	6	7
88	R:R:F229	R:R:M253	21.139	7.46	Yes	No	0	6	7
89	R:R:D251	R:R:M253	10.6047	4.16	No	No	0	5	7
90	R:R:I268	R:R:T272	15.8032	4.56	No	No	0	6	5
91	R:R:P273	R:R:T272	13.2392	5.25	No	No	0	9	5
92	R:R:F296	R:R:P273	11.9466	8.67	Yes	No	0	5	9
93	R:R:L140	R:R:M221	45.1027	2.83	Yes	No	0	7	9
94	R:R:L139	R:R:M221	45.7542	2.83	No	No	0	8	9
95	R:R:V164	R:R:V165	10.5202	1.6	No	No	0	7	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q125	7.59	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I128	8.13	1	Yes	No	0	6	0	1
L:L:?1	R:R:D129	14.36	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M198	8.06	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y202	3.82	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W210	12.05	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W271	3.71	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L278	15.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	6.47	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L297	12.4	1	Yes	No	0	6	0	1
R:R:K39	R:R:L290	5.64	1	No	No	8	3	2	2
R:R:E293	R:R:K39	9.45	1	Yes	No	4	8	1	2
R:R:A101	R:R:I128	3.25	0	No	No	5	6	2	1
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	12.15	0	No	Yes	6	6	2	2
R:R:I128	R:R:L105	5.71	0	No	No	6	6	1	2
R:R:R124	R:R:W121	10	1	Yes	Yes	6	9	2	2
R:R:Q125	R:R:W121	26.29	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	3.86	1	Yes	Yes	9	4	2	1
R:R:Q125	R:R:R124	8.18	1	Yes	Yes	4	6	1	2
R:R:Q125	R:R:Y202	7.89	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	9.2	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	9.2	1	Yes	Yes	5	7	1	2
R:R:L132	R:R:W210	4.56	1	Yes	Yes	7	6	2	1
R:R:L132	R:R:W271	5.69	1	Yes	Yes	7	8	2	1
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	7.28	1	No	Yes	6	6	2	1
R:R:F267	R:R:V136	5.24	1	Yes	No	9	8	2	2
R:R:V136	R:R:W271	3.68	1	No	Yes	8	8	2	1
R:R:M178	R:R:Y206	5.99	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	12.52	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	16.69	1	No	Yes	6	7	2	2
R:R:D281	R:R:M198	5.54	0	No	No	4	3	2	1
R:R:E293	R:R:M198	18.95	1	Yes	No	4	3	1	1
R:R:A199	R:R:Y202	4	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	11.91	1	Yes	Yes	4	7	1	2
R:R:W210	R:R:W271	3.75	1	Yes	Yes	6	8	1	1
R:R:F267	R:R:N214	4.83	1	Yes	No	9	7	2	2
R:R:N214	R:R:W271	6.78	1	No	Yes	7	8	2	1
R:R:L275	R:R:N214	10.98	1	No	No	6	7	2	2
R:R:F267	R:R:W271	16.04	1	Yes	Yes	9	8	2	1
R:R:L275	R:R:W271	5.69	1	No	Yes	6	8	2	1
R:R:A300	R:R:W271	3.89	0	No	Yes	7	8	2	1
R:R:N303	R:R:W271	10.17	0	No	Yes	9	8	2	1
R:R:E293	R:R:L290	3.98	1	Yes	No	4	3	1	2
R:R:L122	R:R:Y202	2.34	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9J5V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	268
Number of Links	301
Number of Hubs	40
Number of Links mediated by Hubs	155
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	68470
Length Of Smallest Path	3
Average Path Length	15.7668
Length of Longest Path	32
Minimum Path Strength	1.36
Average Path Strength	6.3642
Maximum Path Strength	16.99
Minimum Path Correlation	0.7
Average Path Correlation	0.930062
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	47.342
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.145
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9J5V_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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