psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q125	5.26	Yes	Yes	1	0	4
2	L:L:?1	R:R:I128	5.64	Yes	No	0	0	6
3	L:L:?1	R:R:D129	9.97	Yes	Yes	1	0	5
4	L:L:?1	R:R:M198	5.59	Yes	No	1	0	3
5	L:L:?1	R:R:W210	8.37	Yes	Yes	1	0	6
6	L:L:?1	R:R:L278	10.95	Yes	No	0	0	6
7	L:L:?1	R:R:E293	4.49	Yes	Yes	1	0	4
8	L:L:?1	R:R:L297	8.6	Yes	No	0	0	6
9	R:R:F25	R:R:Q23	8.2	No	No	0	7	3
10	R:R:C190	R:R:C24	7.28	No	No	0	3	5
11	R:R:F25	R:R:F32	10.72	No	No	0	7	2
12	R:R:F25	R:R:I192	7.54	No	No	0	7	1
13	R:R:E28	R:R:N27	6.57	No	No	0	4	8
14	R:R:E28	R:R:F32	20.99	No	No	0	4	2
15	R:R:F33	R:R:L201	23.14	No	No	0	6	1
16	R:R:K39	R:R:Y34	8.36	No	Yes	0	8	6
17	R:R:T113	R:R:Y34	4.99	No	Yes	0	5	6
18	R:R:P200	R:R:Y34	9.74	No	Yes	0	6	6
19	R:R:I192	R:R:R36	7.52	No	No	0	1	3
20	R:R:E193	R:R:R36	12.79	No	No	0	4	3
21	R:R:K39	R:R:L290	5.64	No	No	1	8	3
22	R:R:E293	R:R:K39	9.45	Yes	No	1	4	8
23	R:R:L41	R:R:R114	12.15	No	No	0	2	6
24	R:R:R114	R:R:T43	10.35	No	No	0	6	3
25	R:R:M53	R:R:W45	4.65	No	Yes	0	4	1
26	R:R:P111	R:R:W45	21.62	No	Yes	4	4	1
27	R:R:N112	R:R:W45	6.78	No	Yes	4	4	1
28	R:R:N46	R:R:S49	8.94	No	No	0	2	1
29	R:R:K50	R:R:M53	11.52	No	No	0	3	4
30	R:R:G54	R:R:K50	3.49	No	No	0	4	3
31	R:R:K294	R:R:V52	12.14	No	No	0	4	5
32	R:R:F295	R:R:V52	3.93	No	No	0	4	5
33	R:R:G56	R:R:L298	3.42	No	Yes	0	6	6
34	R:R:F103	R:R:I57	5.02	Yes	No	5	6	4
35	R:R:F107	R:R:I57	3.77	No	No	5	5	4
36	R:R:L298	R:R:V59	4.47	Yes	No	0	6	7
37	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
38	R:R:C60	R:R:F103	5.59	No	Yes	0	6	6
39	R:R:I63	R:R:N67	4.25	Yes	Yes	0	8	9
40	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
41	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
42	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
43	R:R:F96	R:R:M64	4.98	No	No	0	7	6
44	R:R:F103	R:R:M64	4.98	Yes	No	0	6	6
45	R:R:A66	R:R:P308	3.74	No	No	0	8	9
46	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
47	R:R:D95	R:R:N67	8.08	Yes	Yes	0	9	9
48	R:R:F96	R:R:N67	3.62	No	Yes	0	7	9
49	R:R:N67	R:R:P308	4.89	Yes	No	0	9	9
50	R:R:L68	R:R:V72	4.47	No	No	0	4	5
51	R:R:A92	R:R:V70	3.39	No	No	0	9	9
52	R:R:F322	R:R:V70	3.93	No	No	0	6	9
53	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
54	R:R:A73	R:R:F322	4.16	No	No	0	7	6
55	R:R:I74	R:R:Y85	4.84	No	Yes	0	7	9
56	R:R:A89	R:R:I74	4.87	No	No	0	7	7
57	R:R:I74	R:R:M318	5.83	No	Yes	0	7	8
58	R:R:N77	R:R:V76	5.91	Yes	No	0	6	5
59	R:R:N77	R:R:R79	13.26	Yes	No	3	6	6
60	R:R:F80	R:R:N77	8.46	Yes	Yes	3	8	6
61	R:R:N77	R:R:T321	8.77	Yes	No	0	6	7
62	R:R:H81	R:R:R78	9.03	No	No	0	8	6
63	R:R:F80	R:R:R79	9.62	Yes	No	3	8	6
64	R:R:E317	R:R:R79	13.96	No	No	3	7	6
65	R:R:F80	R:R:Y85	19.6	Yes	Yes	0	8	9
66	R:R:E317	R:R:F80	5.83	No	Yes	3	7	8
67	R:R:F80	R:R:M318	13.68	Yes	Yes	0	8	8
68	R:R:H81	R:R:Y86	8.71	No	No	0	8	4
69	R:R:E145	R:R:P83	4.72	Yes	Yes	0	8	6
70	R:R:M159	R:R:P83	8.39	No	Yes	0	6	6
71	R:R:N161	R:R:P83	3.26	No	Yes	0	3	6
72	R:R:P83	R:R:V164	5.3	Yes	No	0	6	7
73	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
74	R:R:E145	R:R:I84	8.2	Yes	No	0	8	8
75	R:R:D315	R:R:Y85	4.6	No	Yes	0	8	9
76	R:R:N161	R:R:Y86	8.14	No	No	0	3	4
77	R:R:V164	R:R:Y86	3.79	No	No	0	7	4
78	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
79	R:R:M88	R:R:Y311	3.59	No	Yes	0	8	9
80	R:R:N138	R:R:N90	13.62	No	No	0	8	9
81	R:R:I168	R:R:N90	11.33	No	No	0	8	9
82	R:R:N90	R:R:W172	9.04	No	No	0	9	9
83	R:R:D95	R:R:L91	5.43	Yes	No	0	9	9
84	R:R:L91	R:R:N138	6.87	No	No	0	9	8
85	R:R:L139	R:R:L91	5.54	No	No	0	8	9
86	R:R:A94	R:R:S135	3.42	No	No	0	8	9
87	R:R:D95	R:R:S135	4.42	Yes	No	0	9	9
88	R:R:D95	R:R:S304	7.36	Yes	No	0	9	9
89	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
90	R:R:F97	R:R:T130	3.89	Yes	No	0	7	6
91	R:R:F97	R:R:S131	3.96	Yes	Yes	0	7	6
92	R:R:F97	R:R:W172	4.01	Yes	No	0	7	9
93	R:R:A98	R:R:S131	3.42	No	Yes	0	8	6
94	R:R:A101	R:R:I128	3.25	No	No	0	5	6
95	R:R:A101	R:R:S131	3.42	No	Yes	0	5	6
96	R:R:L297	R:R:Y102	10.55	No	Yes	0	6	7
97	R:R:L298	R:R:Y102	7.03	Yes	Yes	0	6	7
98	R:R:E301	R:R:Y102	21.32	No	Yes	0	7	7
99	R:R:F103	R:R:F107	13.93	Yes	No	5	6	5
100	R:R:N108	R:R:Y104	6.98	No	No	0	5	5
101	R:R:L105	R:R:R124	12.15	No	Yes	0	6	6
102	R:R:I128	R:R:L105	5.71	No	No	0	6	6
103	R:R:F107	R:R:M106	3.73	No	No	0	5	6
104	R:R:K294	R:R:M106	7.2	No	No	0	4	6
105	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
106	R:R:K294	R:R:T109	4.5	No	No	0	4	5
107	R:R:G110	R:R:P111	4.06	No	No	0	5	4
108	R:R:N112	R:R:P111	8.15	No	No	4	4	4
109	R:R:R115	R:R:T120	3.88	No	Yes	0	3	4
110	R:R:L116	R:R:W121	5.69	No	Yes	1	6	9
111	R:R:L116	R:R:R124	4.86	No	Yes	1	6	6
112	R:R:T117	R:R:T120	4.71	No	Yes	1	6	4
113	R:R:R124	R:R:W121	10	Yes	Yes	1	6	9
114	R:R:Q125	R:R:W121	26.29	Yes	Yes	1	4	9
115	R:R:W121	R:R:Y202	3.86	Yes	Yes	1	9	4
116	R:R:Q125	R:R:R124	8.18	Yes	Yes	1	4	6
117	R:R:Q125	R:R:Y202	7.89	Yes	Yes	1	4	4
118	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
119	R:R:D129	R:R:Y202	9.2	Yes	Yes	1	5	4
120	R:R:D129	R:R:Y206	9.2	Yes	Yes	1	5	7
121	R:R:L132	R:R:S131	4.5	Yes	Yes	0	7	6
122	R:R:L132	R:R:W210	4.56	Yes	Yes	1	7	6
123	R:R:L132	R:R:W271	5.69	Yes	Yes	1	7	8
124	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
125	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
126	R:R:T133	R:R:W210	7.28	No	Yes	1	6	6
127	R:R:F213	R:R:T133	3.89	No	No	0	5	6
128	R:R:A134	R:R:W172	3.89	No	No	0	7	9
129	R:R:T217	R:R:V136	4.76	Yes	No	0	7	8
130	R:R:F267	R:R:V136	5.24	Yes	No	1	9	8
131	R:R:V136	R:R:W271	3.68	No	Yes	1	8	8
132	R:R:A137	R:R:I171	4.87	No	No	0	5	7
133	R:R:I171	R:R:N138	8.5	No	No	0	7	8
134	R:R:L139	R:R:N307	8.24	No	No	0	8	9
135	R:R:L140	R:R:T217	7.37	Yes	Yes	0	7	7
136	R:R:A141	R:R:I171	3.25	No	No	0	8	7
137	R:R:I142	R:R:R146	6.26	No	No	2	8	9
138	R:R:I142	R:R:Y311	9.67	No	Yes	2	8	9
139	R:R:R146	R:R:Y225	9.26	No	Yes	2	9	9
140	R:R:R146	R:R:Y311	12.35	No	Yes	2	9	9
141	R:R:F151	R:R:H147	22.63	Yes	Yes	6	6	7
142	R:R:H147	R:R:L224	7.71	Yes	No	0	7	6
143	R:R:H147	R:R:H227	10.75	Yes	No	6	7	5
144	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
145	R:R:R152	R:R:T149	7.76	No	No	0	5	8
146	R:R:F151	R:R:V150	5.24	Yes	No	0	6	8
147	R:R:I228	R:R:V150	9.22	No	No	0	9	8
148	R:R:F151	R:R:H227	13.58	Yes	No	6	6	5
149	R:R:F151	R:R:Y231	11.35	Yes	No	0	6	6
150	R:R:R152	R:R:T157	10.35	No	No	0	5	4
151	R:R:M153	R:R:R235	4.96	No	No	0	7	7
152	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
153	R:R:H156	R:R:L155	10.29	No	No	0	4	8
154	R:R:F213	R:R:M174	3.73	No	No	0	5	4
155	R:R:M178	R:R:Y206	5.99	Yes	Yes	1	5	7
156	R:R:F209	R:R:M178	3.73	No	Yes	0	6	5
157	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
158	R:R:I181	R:R:P182	3.39	No	No	0	5	6
159	R:R:I181	R:R:W186	3.52	No	No	0	5	6
160	R:R:P182	R:R:Y202	12.52	No	Yes	1	6	4
161	R:R:P182	R:R:Y206	16.69	No	Yes	1	6	7
162	R:R:G185	R:R:V184	3.68	No	No	0	5	5
163	R:R:S205	R:R:W186	11.12	No	No	0	5	6
164	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
165	R:R:I189	R:R:N187	5.66	Yes	No	0	3	6
166	R:R:C188	R:R:C195	7.28	No	No	7	5	9
167	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
168	R:R:L207	R:R:S196	4.5	No	No	0	6	5
169	R:R:D281	R:R:S196	8.83	No	No	0	4	5
170	R:R:D281	R:R:N197	14.81	No	No	0	4	5
171	R:R:D281	R:R:M198	5.54	No	No	0	4	3
172	R:R:E293	R:R:M198	18.95	Yes	No	1	4	3
173	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
174	R:R:Y202	R:R:Y206	11.91	Yes	Yes	1	4	7
175	R:R:S203	R:R:S205	4.89	No	No	0	5	5
176	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
177	R:R:L207	R:R:V282	4.47	No	Yes	0	6	5
178	R:R:V208	R:R:V282	4.81	No	Yes	0	4	5
179	R:R:W210	R:R:W271	3.75	Yes	Yes	1	6	8
180	R:R:F213	R:R:T217	6.49	No	Yes	0	5	7
181	R:R:F267	R:R:N214	4.83	Yes	No	1	9	7
182	R:R:N214	R:R:W271	6.78	No	Yes	1	7	8
183	R:R:L275	R:R:N214	10.98	No	No	1	6	7
184	R:R:F218	R:R:V222	6.55	No	No	0	5	4
185	R:R:F218	R:R:F267	12.86	No	Yes	0	5	9
186	R:R:F218	R:R:I268	5.02	No	No	0	5	6
187	R:R:L264	R:R:V222	5.96	No	No	0	7	4
188	R:R:V260	R:R:Y225	5.05	No	Yes	0	8	9
189	R:R:V263	R:R:Y225	3.79	No	Yes	2	8	9
190	R:R:L264	R:R:Y225	4.69	No	Yes	0	7	9
191	R:R:Y225	R:R:Y311	4.96	Yes	Yes	2	9	9
192	R:R:F229	R:R:M253	7.46	Yes	No	0	6	7
193	R:R:F229	R:R:L256	9.74	Yes	No	0	6	7
194	R:R:F229	R:R:L257	10.96	Yes	No	0	6	7
195	R:R:R235	R:R:Y231	11.32	No	No	0	7	6
196	R:R:L256	R:R:V232	4.47	No	No	0	7	7
197	R:R:M253	R:R:R233	4.96	No	No	0	7	5
198	R:R:D251	R:R:M253	4.16	No	No	0	5	7
199	R:R:R314	R:R:S255	6.59	No	No	0	7	7
200	R:R:T259	R:R:Y313	4.99	No	No	0	8	5
201	R:R:I262	R:R:I310	4.42	No	No	0	6	8
202	R:R:I262	R:R:Y313	3.63	No	No	0	6	5
203	R:R:V263	R:R:Y311	7.57	No	Yes	2	8	9
204	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
205	R:R:I268	R:R:T272	4.56	No	No	0	6	5
206	R:R:C270	R:R:I269	3.27	No	No	0	9	5
207	R:R:C270	R:R:L299	4.76	No	No	0	9	7
208	R:R:C270	R:R:N303	7.87	No	No	0	9	9
209	R:R:L275	R:R:W271	5.69	No	Yes	1	6	8
210	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
211	R:R:N303	R:R:W271	10.17	No	Yes	0	9	8
212	R:R:P273	R:R:T272	5.25	No	No	0	9	5
213	R:R:F296	R:R:P273	8.67	Yes	No	0	5	9
214	R:R:L277	R:R:V289	4.47	No	No	0	4	4
215	R:R:F296	R:R:L277	8.53	Yes	No	0	5	4
216	R:R:C283	R:R:V282	3.42	No	Yes	0	4	5
217	R:R:C284	R:R:P285	3.77	No	No	0	4	3
218	R:R:C284	R:R:C287	7.28	No	No	0	4	5
219	R:R:E293	R:R:L290	3.98	Yes	No	1	4	3
220	R:R:F302	R:R:M306	12.44	No	No	0	5	6
221	R:R:N303	R:R:N307	4.09	No	No	0	9	9
222	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
223	R:R:F322	R:R:S312	5.28	No	No	0	6	7
224	R:R:D315	R:R:M318	4.16	No	Yes	0	8	8
225	R:R:R314	R:R:Y313	3.09	No	No	0	7	5
226	R:R:I189	R:R:V118	3.07	Yes	No	0	3	2
227	R:R:I181	R:R:V177	3.07	No	No	0	5	4
228	R:R:I212	R:R:V208	3.07	No	No	0	4	4
229	R:R:I176	R:R:T130	3.04	No	No	0	3	6
230	R:R:F296	R:R:G274	3.01	Yes	No	0	5	5
231	R:R:L140	R:R:V220	2.98	Yes	No	0	7	5
232	R:R:L280	R:R:V289	2.98	No	No	0	5	4
233	R:R:L116	R:R:T120	2.95	No	Yes	1	6	4
234	R:R:I309	R:R:I310	2.94	No	No	0	7	8
235	R:R:A42	R:R:H40	2.93	No	No	0	4	2
236	R:R:M106	R:R:M53	2.89	No	No	0	6	4
237	R:R:F82	R:R:P83	2.89	No	Yes	0	7	6
238	R:R:K258	R:R:M254	2.88	No	No	0	7	5
239	R:R:I61	R:R:L65	2.85	No	No	0	4	4
240	R:R:I144	R:R:L140	2.85	No	Yes	0	6	7
241	R:R:I144	R:R:L224	2.85	No	No	0	6	6
242	R:R:L139	R:R:M221	2.83	No	No	0	8	9
243	R:R:L140	R:R:M221	2.83	Yes	No	0	7	9
244	R:R:L298	R:R:L55	2.77	Yes	No	0	6	4
245	R:R:A305	R:R:F62	2.77	No	No	0	7	4
246	R:R:A305	R:R:F302	2.77	No	No	0	7	5
247	R:R:A143	R:R:Y225	2.67	No	Yes	0	8	9
248	R:R:R162	R:R:V165	2.62	No	No	0	5	1
249	R:R:M237	R:R:R233	2.48	No	No	0	5	5
250	R:R:F96	R:R:L100	2.44	No	No	0	7	4
251	R:R:F97	R:R:L127	2.44	Yes	No	0	7	5
252	R:R:I30	R:R:Y34	2.42	No	Yes	0	6	6
253	R:R:L122	R:R:Y202	2.34	No	Yes	0	5	4
254	R:R:F32	R:R:F33	2.14	No	No	0	2	6
255	R:R:G126	R:R:G179	2.11	No	No	0	6	7
256	R:R:F296	R:R:Y292	2.06	Yes	No	0	5	3
257	R:R:A42	R:R:G110	1.95	No	No	0	4	5
258	R:R:A134	R:R:A175	1.79	No	No	0	7	8
259	R:R:P200	R:R:S37	1.78	No	No	0	6	7
260	R:R:G265	R:R:I268	1.76	No	No	0	4	6
261	R:R:C188	R:R:S203	1.72	No	No	7	5	5
262	R:R:C195	R:R:S203	1.72	No	No	7	9	5
263	R:R:A31	R:R:S29	1.71	No	No	0	2	4
264	R:R:C287	R:R:V289	1.71	No	No	0	5	4
265	R:R:G185	R:R:N187	1.7	No	No	0	5	6
266	R:R:L201	R:R:P200	1.64	No	No	0	1	6
267	R:R:S49	R:R:V48	1.62	No	No	0	1	3
268	R:R:A266	R:R:M306	1.61	No	No	0	6	6
269	R:R:S119	R:R:T117	1.6	No	No	1	1	6
270	R:R:S119	R:R:T120	1.6	No	Yes	1	1	4
271	R:R:V150	R:R:V232	1.6	No	No	0	8	7
272	R:R:V164	R:R:V165	1.6	No	No	0	7	1
273	R:R:V166	R:R:V170	1.6	No	No	0	3	3
274	R:R:V169	R:R:V170	1.6	No	No	0	4	3
275	R:R:V219	R:R:V220	1.6	No	No	0	3	5
276	R:R:T217	R:R:V216	1.59	Yes	No	0	7	4
277	R:R:T236	R:R:V232	1.59	No	No	0	5	7
278	R:R:T272	R:R:V276	1.59	No	No	0	5	6
279	R:R:C283	R:R:L279	1.59	No	No	0	4	6
280	R:R:A211	R:R:L279	1.58	No	No	0	4	6
281	R:R:T236	R:R:T252	1.57	No	No	0	5	5
282	R:R:A31	R:R:N35	1.56	No	No	0	2	7
283	R:R:A42	R:R:N46	1.56	No	No	0	4	2
284	R:R:A291	R:R:D288	1.54	No	No	0	2	1
285	R:R:I57	R:R:T58	1.52	No	No	0	4	5
286	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
287	R:R:L87	R:R:V167	1.49	No	No	0	8	6
288	R:R:L224	R:R:V223	1.49	No	No	0	6	4
289	R:R:L257	R:R:V261	1.49	No	No	0	7	5
290	R:R:L41	R:R:T113	1.47	No	No	0	2	5
291	R:R:E145	R:R:T149	1.41	Yes	No	0	8	8
292	R:R:D251	R:R:M254	1.39	No	No	0	5	5
293	R:R:L65	R:R:L69	1.38	No	No	0	4	7
294	R:R:L123	R:R:L127	1.38	No	No	0	4	5
295	R:R:R162	R:R:S160	1.32	No	No	0	5	8
296	R:R:E193	R:R:N194	1.31	No	No	0	4	3
297	R:R:I189	R:R:Y26	1.21	Yes	No	0	3	4
298	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
299	R:R:E44	R:R:W45	1.09	No	Yes	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.35875	8	1	0
2	R:R:Y34	5.334	5	0	6
3	R:R:W45	8.535	4	4	1
4	R:R:I63	4.3575	4	0	8
5	R:R:N67	5.106	5	0	9
6	R:R:N77	9.1	4	3	6
7	R:R:F80	11.438	5	3	8
8	R:R:P83	4.912	5	0	6
9	R:R:Y85	8.1675	4	0	9
10	R:R:D95	6.674	5	0	9
11	R:R:F97	3.575	4	0	7
12	R:R:Y102	11.07	4	0	7
13	R:R:F103	7.38	4	5	6
14	R:R:T120	3.285	4	1	4
15	R:R:W121	11.46	4	1	9
16	R:R:R124	8.484	5	1	6
17	R:R:Q125	11.905	4	1	4
18	R:R:D129	8.35	4	1	5
19	R:R:S131	3.825	4	0	6
20	R:R:L132	5.345	4	1	7
21	R:R:L140	4.0075	4	0	7
22	R:R:E145	4.9075	4	0	8
23	R:R:H147	11.5975	4	6	7
24	R:R:F151	13.2	4	6	6
25	R:R:M178	5.185	4	1	5
26	R:R:I189	3.555	4	0	3
27	R:R:Y202	7.38857	7	1	4
28	R:R:Y206	9.53	5	1	7
29	R:R:W210	5.49	5	1	6
30	R:R:T217	5.0525	4	0	7
31	R:R:Y225	5.07	6	2	9
32	R:R:F229	7.4175	4	0	6
33	R:R:F267	9.7425	4	1	9
34	R:R:W271	6.96125	8	1	8
35	R:R:V282	5.365	4	0	5
36	R:R:E293	9.2175	4	1	4
37	R:R:F296	5.5675	4	0	5
38	R:R:L298	4.4225	4	0	6
39	R:R:Y311	6.96167	6	2	9
40	R:R:M318	6.7225	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E293	42.3344	4.49	Yes	Yes	1	0	4
2	R:R:E293	R:R:K39	41.1295	9.45	Yes	No	1	4	8
3	R:R:K39	R:R:Y34	39.9874	8.36	No	Yes	0	8	6
4	R:R:P200	R:R:Y34	27.8053	9.74	No	Yes	0	6	6
5	R:R:L201	R:R:P200	25.0037	1.64	No	No	0	1	6
6	R:R:F33	R:R:L201	14.9653	23.14	No	No	0	6	1
7	R:R:F32	R:R:F33	13.5016	2.14	No	No	0	2	6
8	L:L:?1	R:R:L297	12.0823	8.6	Yes	No	0	0	6
9	R:R:L297	R:R:Y102	11.576	10.55	No	Yes	0	6	7
10	R:R:C60	R:R:Y102	21.4333	5.38	No	Yes	0	6	7
11	R:R:C60	R:R:F103	21.1376	5.59	No	Yes	0	6	6
12	R:R:F103	R:R:F107	28.7847	13.93	Yes	No	5	6	5
13	R:R:F107	R:R:M106	27.5983	3.73	No	No	0	5	6
14	R:R:M106	R:R:M53	20.2691	2.89	No	No	0	6	4
15	R:R:M53	R:R:W45	15.7008	4.65	No	Yes	0	4	1
16	R:R:P111	R:R:W45	11.0438	21.62	No	Yes	4	4	1
17	L:L:?1	R:R:W210	69.2637	8.37	Yes	Yes	1	0	6
18	R:R:W210	R:R:W271	63.9525	3.75	Yes	Yes	1	6	8
19	R:R:N303	R:R:W271	62.9103	10.17	No	Yes	0	9	8
20	R:R:N303	R:R:N307	62.4815	4.09	No	No	0	9	9
21	R:R:D95	R:R:N307	81.5605	8.08	Yes	No	0	9	9
22	R:R:D95	R:R:N67	100	8.08	Yes	Yes	0	9	9
23	R:R:I63	R:R:N67	10.2639	4.25	Yes	Yes	0	8	9
24	R:R:A305	R:R:I63	11.8791	3.25	No	Yes	0	7	8
25	R:R:F103	R:R:M64	20.7126	4.98	Yes	No	0	6	6
26	R:R:F96	R:R:M64	20.9713	4.98	No	No	0	7	6
27	R:R:A92	R:R:N67	93.3878	4.69	No	Yes	0	9	9
28	R:R:A92	R:R:V70	92.5673	3.39	No	No	0	9	9
29	R:R:F322	R:R:V70	91.7394	3.93	No	No	0	6	9
30	R:R:A73	R:R:F322	90.0614	4.16	No	No	0	7	6
31	R:R:A73	R:R:M318	89.2113	3.22	No	Yes	0	7	8
32	R:R:I74	R:R:M318	28.3708	5.83	No	Yes	0	7	8
33	R:R:I74	R:R:Y85	26.2456	4.84	No	Yes	0	7	9
34	R:R:F80	R:R:M318	32.976	13.68	Yes	Yes	0	8	8
35	R:R:F80	R:R:Y85	26.5634	19.6	Yes	Yes	0	8	9
36	R:R:D315	R:R:M318	27.103	4.16	No	Yes	0	8	8
37	R:R:D315	R:R:Y85	26.0164	4.6	No	Yes	0	8	9
38	R:R:I84	R:R:Y85	75.414	3.63	No	Yes	0	8	9
39	R:R:E145	R:R:I84	71.9951	8.2	Yes	No	0	8	8
40	R:R:E145	R:R:P83	48.4772	4.72	Yes	Yes	0	8	6
41	R:R:N161	R:R:P83	13.7493	3.26	No	Yes	0	3	6
42	R:R:N161	R:R:Y86	10.5928	8.14	No	No	0	3	4
43	R:R:H81	R:R:Y86	14.1447	8.71	No	No	0	8	4
44	R:R:P83	R:R:V164	24.6932	5.3	Yes	No	0	6	7
45	R:R:V164	R:R:Y86	10.6298	3.79	No	No	0	7	4
46	R:R:F267	R:R:W271	32.5251	16.04	Yes	Yes	1	9	8
47	R:R:F218	R:R:F267	37.8511	12.86	No	Yes	0	5	9
48	R:R:F218	R:R:V222	21.4962	6.55	No	No	0	5	4
49	R:R:L264	R:R:V222	20.3467	5.96	No	No	0	7	4
50	R:R:L264	R:R:Y225	19.164	4.69	No	Yes	0	7	9
51	R:R:Y225	R:R:Y311	12.0084	4.96	Yes	Yes	2	9	9
52	R:R:F97	R:R:S131	11.1953	3.96	Yes	Yes	0	7	6
53	R:R:L132	R:R:S131	10.6889	4.5	Yes	Yes	0	7	6
54	R:R:D95	R:R:L91	31.8081	5.43	Yes	No	0	9	9
55	R:R:L91	R:R:N138	11.406	6.87	No	No	0	9	8
56	R:R:L139	R:R:N307	26.8998	8.24	No	No	0	8	9
57	R:R:L139	R:R:L91	27.0735	5.54	No	No	0	8	9
58	R:R:E301	R:R:L132	12.6478	6.63	No	Yes	0	7	7
59	R:R:E301	R:R:Y102	12.2302	21.32	No	Yes	0	7	7
60	L:L:?1	R:R:Q125	21.8103	5.26	Yes	Yes	1	0	4
61	R:R:L116	R:R:T120	11.0844	2.95	No	Yes	1	6	4
62	L:L:?1	R:R:D129	11.0881	9.97	Yes	Yes	1	0	5
63	R:R:M178	R:R:W210	11.3949	3.49	Yes	Yes	1	5	6
64	R:R:T133	R:R:W210	14.2408	7.28	No	Yes	1	6	6
65	R:R:F213	R:R:T133	17.6412	3.89	No	No	0	5	6
66	R:R:F213	R:R:T217	18.6613	6.49	No	Yes	0	5	7
67	R:R:V136	R:R:W271	21.4962	3.68	No	Yes	1	8	8
68	R:R:T217	R:R:V136	26.8887	4.76	Yes	No	0	7	8
69	R:R:L140	R:R:T217	42.6486	7.37	Yes	Yes	0	7	7
70	R:R:I144	R:R:L140	76.5449	2.85	No	Yes	0	6	7
71	R:R:I144	R:R:L224	74.745	2.85	No	No	0	6	6
72	R:R:H147	R:R:L224	71.0933	7.71	Yes	No	0	7	6
73	R:R:F151	R:R:H147	36.5095	22.63	Yes	Yes	6	6	7
74	R:R:H147	R:R:I228	30.8213	5.3	Yes	No	0	7	9
75	R:R:E145	R:R:T149	13.8343	1.41	Yes	No	0	8	8
76	R:R:R152	R:R:T149	10.2935	7.76	No	No	0	5	8
77	R:R:F151	R:R:V150	29.1174	5.24	Yes	No	0	6	8
78	R:R:I228	R:R:V150	29.0841	9.22	No	No	0	9	8
79	L:L:?1	R:R:M198	16.3476	5.59	Yes	No	1	0	3
80	R:R:D281	R:R:M198	16.4215	5.54	No	No	0	4	3
81	R:R:D281	R:R:S196	13.5016	8.83	No	No	0	4	5
82	R:R:L207	R:R:S196	12.0306	4.5	No	No	0	6	5
83	R:R:L207	R:R:V282	10.5522	4.47	No	Yes	0	6	5
84	R:R:F218	R:R:I268	17.1755	5.02	No	No	0	5	6
85	R:R:V150	R:R:V232	54.2911	1.6	No	No	0	8	7
86	R:R:L256	R:R:V232	43.1291	4.47	No	No	0	7	7
87	R:R:F229	R:R:L256	39.5698	9.74	Yes	No	0	6	7
88	R:R:F229	R:R:M253	23.8247	7.46	Yes	No	0	6	7
89	R:R:D251	R:R:M253	11.9493	4.16	No	No	0	5	7
90	R:R:I268	R:R:T272	14.81	4.56	No	No	0	6	5
91	R:R:P273	R:R:T272	12.415	5.25	No	No	0	9	5
92	R:R:F296	R:R:P273	11.2064	8.67	Yes	No	0	5	9
93	R:R:L140	R:R:M221	47.5495	2.83	Yes	No	0	7	9
94	R:R:L139	R:R:M221	47.945	2.83	No	No	0	8	9
95	R:R:V164	R:R:V165	10.6409	1.6	No	No	0	7	1
96	R:R:M178	R:R:Y206	13.4942	5.99	Yes	Yes	1	5	7
97	R:R:F96	R:R:N67	22.1319	3.62	No	Yes	0	7	9
98	R:R:L132	R:R:W271	15.4901	5.69	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q125	5.26	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I128	5.64	1	Yes	No	0	6	0	1
L:L:?1	R:R:D129	9.97	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M198	5.59	1	Yes	No	0	3	0	1
L:L:?1	R:R:W210	8.37	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	10.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	4.49	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L297	8.6	1	Yes	No	0	6	0	1
R:R:K39	R:R:L290	5.64	1	No	No	8	3	2	2
R:R:E293	R:R:K39	9.45	1	Yes	No	4	8	1	2
R:R:A101	R:R:I128	3.25	0	No	No	5	6	2	1
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	12.15	0	No	Yes	6	6	2	2
R:R:I128	R:R:L105	5.71	0	No	No	6	6	1	2
R:R:R124	R:R:W121	10	1	Yes	Yes	6	9	2	2
R:R:Q125	R:R:W121	26.29	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	3.86	1	Yes	Yes	9	4	2	2
R:R:Q125	R:R:R124	8.18	1	Yes	Yes	4	6	1	2
R:R:Q125	R:R:Y202	7.89	1	Yes	Yes	4	4	1	2
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	9.2	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	9.2	1	Yes	Yes	5	7	1	2
R:R:L132	R:R:W210	4.56	1	Yes	Yes	7	6	2	1
R:R:L132	R:R:W271	5.69	1	Yes	Yes	7	8	2	2
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	7.28	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	5.99	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:D281	R:R:M198	5.54	0	No	No	4	3	2	1
R:R:E293	R:R:M198	18.95	1	Yes	No	4	3	1	1
R:R:Y202	R:R:Y206	11.91	1	Yes	Yes	4	7	2	2
R:R:W210	R:R:W271	3.75	1	Yes	Yes	6	8	1	2
R:R:E293	R:R:L290	3.98	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9J5V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	268
Number of Links	299
Number of Hubs	40
Number of Links mediated by Hubs	153
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	66234
Length Of Smallest Path	3
Average Path Length	16.089
Length of Longest Path	33
Minimum Path Strength	1.36
Average Path Strength	6.3092
Maximum Path Strength	16.99
Minimum Path Correlation	0.7
Average Path Correlation	0.928977
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.2004
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.5561
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cation binding • magnesium ion binding • ion binding • metal ion binding • small molecule binding • guanyl nucleotide binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G protein-coupled serotonin receptor binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • GTP binding • purine ribonucleoside triphosphate binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of protein localization to cell cortex • macromolecule localization • positive regulation of protein localization • intracellular protein localization • protein localization to cell cortex • cell division • cellular response to forskolin • response to forskolin • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • intracellular membrane-bounded organelle • phospholipid binding • lipid binding • lysophosphatidic acid binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • cell chemotaxis • chemotaxis • response to external stimulus • taxis • cell migration • cell motility • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • postsynapse • postsynaptic membrane • synaptic membrane • presynapse • presynaptic membrane • glutamatergic synapse • dendritic shaft • neuron spine • dendritic spine • neuronal cell body • cell surface • GABA-ergic synapse • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9J5V_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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