psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K39	7.96	Yes	No	0	0	8
2	L:L:?1	R:R:T109	5.2	Yes	No	0	0	5
3	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
5	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
7	L:L:?1	R:R:L207	3.91	Yes	No	1	0	6
8	L:L:?1	R:R:W210	6.43	Yes	Yes	1	0	6
9	L:L:?1	R:R:L278	3.91	Yes	No	1	0	6
10	L:L:?1	R:R:E293	24.32	Yes	No	0	0	4
11	L:L:?1	R:R:K294	6.97	Yes	No	0	0	4
12	L:L:?1	R:R:L297	16.61	Yes	No	0	0	6
13	R:R:C190	R:R:C24	7.28	No	No	0	3	5
14	R:R:F25	R:R:N27	6.04	No	No	4	7	8
15	R:R:E28	R:R:F25	5.83	Yes	No	4	4	7
16	R:R:E28	R:R:N27	3.94	Yes	No	4	4	8
17	R:R:E28	R:R:F32	22.15	Yes	No	4	4	2
18	R:R:E28	R:R:F33	20.99	Yes	Yes	4	4	6
19	R:R:I30	R:R:L116	4.28	No	Yes	0	6	6
20	R:R:F32	R:R:F33	4.29	No	Yes	4	2	6
21	R:R:F33	R:R:I192	8.79	Yes	No	0	6	1
22	R:R:F33	R:R:L201	20.7	Yes	No	0	6	1
23	R:R:K39	R:R:Y34	11.94	No	Yes	0	8	6
24	R:R:L41	R:R:Y34	3.52	No	Yes	0	2	6
25	R:R:T113	R:R:Y34	7.49	No	Yes	0	5	6
26	R:R:P200	R:R:Y34	4.17	No	Yes	0	6	6
27	R:R:I192	R:R:R36	8.77	No	No	0	1	3
28	R:R:G38	R:R:S37	3.71	No	No	0	4	7
29	R:R:P200	R:R:S37	3.56	No	No	0	6	7
30	R:R:L41	R:R:T43	5.9	No	No	0	2	3
31	R:R:L41	R:R:R114	9.72	No	No	0	2	6
32	R:R:P111	R:R:W45	20.27	No	No	0	4	1
33	R:R:N112	R:R:W45	5.65	No	No	0	4	1
34	R:R:N46	R:R:S49	8.94	No	No	0	2	1
35	R:R:K50	R:R:M53	5.76	No	No	0	3	4
36	R:R:K294	R:R:V52	13.66	No	No	0	4	5
37	R:R:G54	R:R:M53	5.24	No	No	0	4	4
38	R:R:G56	R:R:M106	3.49	No	No	0	6	6
39	R:R:F103	R:R:I57	5.02	No	No	0	6	4
40	R:R:L298	R:R:V59	5.96	No	No	0	6	7
41	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
42	R:R:C60	R:R:F103	6.98	No	No	0	6	6
43	R:R:G99	R:R:I63	3.53	No	No	0	7	8
44	R:R:I63	R:R:S304	4.64	No	No	0	8	9
45	R:R:F96	R:R:M64	11.2	Yes	No	5	7	6
46	R:R:L100	R:R:M64	5.65	No	No	5	4	6
47	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
48	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
49	R:R:F96	R:R:N67	3.62	Yes	Yes	0	7	9
50	R:R:N67	R:R:P308	4.89	Yes	No	0	9	9
51	R:R:F322	R:R:L69	17.05	No	No	0	6	7
52	R:R:A92	R:R:V70	3.39	No	No	0	9	9
53	R:R:M318	R:R:V70	4.56	Yes	No	0	8	9
54	R:R:I74	R:R:Y85	7.25	No	Yes	0	7	9
55	R:R:A89	R:R:I74	4.87	No	No	0	7	7
56	R:R:F80	R:R:N77	9.67	Yes	No	3	8	6
57	R:R:N77	R:R:T321	7.31	No	No	3	6	7
58	R:R:F80	R:R:Y85	18.57	Yes	Yes	3	8	9
59	R:R:D315	R:R:F80	7.17	Yes	Yes	3	8	8
60	R:R:F80	R:R:M318	8.71	Yes	Yes	3	8	8
61	R:R:F80	R:R:T321	3.89	Yes	No	3	8	7
62	R:R:H81	R:R:Y86	10.89	No	No	0	8	4
63	R:R:F82	R:R:P83	4.33	No	Yes	0	7	6
64	R:R:E145	R:R:P83	4.72	No	Yes	0	8	6
65	R:R:P83	R:R:V164	5.3	Yes	Yes	0	6	7
66	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
67	R:R:E145	R:R:I84	12.3	No	No	0	8	8
68	R:R:D315	R:R:Y85	9.2	Yes	Yes	3	8	9
69	R:R:N161	R:R:Y86	15.12	No	No	0	3	4
70	R:R:V164	R:R:Y86	3.79	Yes	No	0	7	4
71	R:R:A141	R:R:L87	4.73	No	No	0	8	8
72	R:R:E145	R:R:L87	6.63	No	No	0	8	8
73	R:R:L87	R:R:V164	4.47	No	Yes	0	8	7
74	R:R:M88	R:R:Y311	7.18	No	Yes	0	8	9
75	R:R:N138	R:R:N90	12.26	Yes	No	0	8	9
76	R:R:I168	R:R:N90	14.16	No	No	0	8	9
77	R:R:N90	R:R:W172	6.78	No	No	0	9	9
78	R:R:D95	R:R:L91	5.43	Yes	Yes	2	9	9
79	R:R:L91	R:R:N138	8.24	Yes	Yes	0	9	8
80	R:R:L139	R:R:L91	4.15	No	Yes	2	8	9
81	R:R:I142	R:R:L91	4.28	No	Yes	2	8	9
82	R:R:L91	R:R:N307	4.12	Yes	Yes	2	9	9
83	R:R:D95	R:R:S304	4.42	Yes	No	0	9	9
84	R:R:D95	R:R:N307	8.08	Yes	Yes	2	9	9
85	R:R:F96	R:R:L100	3.65	Yes	No	5	7	4
86	R:R:F97	R:R:T130	3.89	No	No	0	7	6
87	R:R:F97	R:R:W172	6.01	No	No	0	7	9
88	R:R:A98	R:R:S131	3.42	No	No	0	8	6
89	R:R:A98	R:R:S304	3.42	No	No	0	8	9
90	R:R:A101	R:R:S131	3.42	No	No	0	5	6
91	R:R:M106	R:R:Y102	5.99	No	Yes	0	6	7
92	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
93	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
94	R:R:E301	R:R:Y102	23.57	No	Yes	0	7	7
95	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
96	R:R:L127	R:R:Y104	3.52	No	No	0	5	5
97	R:R:L105	R:R:R124	6.07	No	Yes	0	6	6
98	R:R:I128	R:R:L105	4.28	No	No	0	6	6
99	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
100	R:R:G110	R:R:P111	4.06	No	No	0	5	4
101	R:R:L116	R:R:W121	3.42	Yes	Yes	1	6	9
102	R:R:L116	R:R:R124	4.86	Yes	Yes	1	6	6
103	R:R:T117	R:R:T120	4.71	No	Yes	1	6	4
104	R:R:R124	R:R:W121	7	Yes	Yes	1	6	9
105	R:R:Q125	R:R:W121	15.33	Yes	Yes	1	4	9
106	R:R:P200	R:R:W121	5.4	No	Yes	0	6	9
107	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
108	R:R:L122	R:R:Y202	4.69	No	Yes	0	5	4
109	R:R:Q125	R:R:R124	9.35	Yes	Yes	1	4	6
110	R:R:Q125	R:R:Y202	5.64	Yes	Yes	1	4	4
111	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
112	R:R:D129	R:R:Y202	8.05	Yes	Yes	1	5	4
113	R:R:D129	R:R:Y206	10.34	Yes	Yes	1	5	7
114	R:R:I176	R:R:T130	4.56	No	No	0	3	6
115	R:R:L132	R:R:S131	4.5	Yes	No	0	7	6
116	R:R:L132	R:R:W210	3.42	Yes	Yes	1	7	6
117	R:R:L132	R:R:W271	7.97	Yes	Yes	1	7	8
118	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
119	R:R:M178	R:R:T133	4.52	Yes	No	1	5	6
120	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
121	R:R:A134	R:R:W172	3.89	No	No	0	7	9
122	R:R:N214	R:R:V136	5.91	Yes	Yes	1	7	8
123	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
124	R:R:F267	R:R:V136	6.55	Yes	Yes	1	9	8
125	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
126	R:R:A137	R:R:I171	4.87	No	No	0	5	7
127	R:R:I171	R:R:N138	9.91	No	Yes	0	7	8
128	R:R:L139	R:R:N307	10.98	No	Yes	2	8	9
129	R:R:L139	R:R:Y311	3.52	No	Yes	2	8	9
130	R:R:I144	R:R:L140	7.14	No	No	0	6	7
131	R:R:L140	R:R:T217	5.9	No	No	0	7	7
132	R:R:I142	R:R:R146	3.76	No	No	2	8	9
133	R:R:I142	R:R:Y311	9.67	No	Yes	2	8	9
134	R:R:A143	R:R:Y225	4	No	Yes	0	8	9
135	R:R:R146	R:R:Y225	9.26	No	Yes	0	9	9
136	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
137	R:R:F151	R:R:H147	20.36	Yes	Yes	6	6	7
138	R:R:H147	R:R:L224	11.57	Yes	No	0	7	6
139	R:R:H147	R:R:H227	8.36	Yes	No	6	7	5
140	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
141	R:R:R152	R:R:T149	7.76	No	No	0	5	8
142	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
143	R:R:I228	R:R:V150	9.22	No	No	0	9	8
144	R:R:F151	R:R:H227	15.84	Yes	No	6	6	5
145	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
146	R:R:R152	R:R:T157	5.17	No	No	0	5	4
147	R:R:M159	R:R:R152	4.96	No	No	0	6	5
148	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
149	R:R:H156	R:R:L155	9	No	No	0	4	8
150	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
151	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
152	R:R:M178	R:R:W210	4.65	Yes	Yes	1	5	6
153	R:R:F213	R:R:M178	4.98	No	Yes	0	5	5
154	R:R:I181	R:R:P182	3.39	No	No	0	5	6
155	R:R:P182	R:R:Y202	9.74	No	Yes	1	6	4
156	R:R:P182	R:R:Y206	23.64	No	Yes	1	6	7
157	R:R:G185	R:R:V184	3.68	No	No	0	5	5
158	R:R:S205	R:R:W186	8.65	No	No	0	5	6
159	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
160	R:R:I189	R:R:N187	7.08	No	No	0	3	6
161	R:R:C188	R:R:C195	7.28	No	No	0	5	9
162	R:R:I189	R:R:L201	4.28	No	No	0	3	1
163	R:R:D191	R:R:N194	16.16	No	No	0	4	3
164	R:R:C195	R:R:S203	3.44	No	No	0	9	5
165	R:R:A199	R:R:S196	3.42	No	No	0	4	5
166	R:R:D281	R:R:S196	4.42	No	No	0	4	5
167	R:R:D281	R:R:N197	13.46	No	No	0	4	5
168	R:R:L277	R:R:M198	7.07	No	Yes	0	4	3
169	R:R:D281	R:R:M198	9.7	No	Yes	0	4	3
170	R:R:L290	R:R:M198	4.24	No	Yes	0	3	3
171	R:R:E293	R:R:M198	14.89	No	Yes	0	4	3
172	R:R:Y202	R:R:Y206	5.96	Yes	Yes	1	4	7
173	R:R:L207	R:R:Y202	3.52	No	Yes	1	6	4
174	R:R:S203	R:R:S205	4.89	No	No	0	5	5
175	R:R:D204	R:R:V282	8.76	No	No	0	4	5
176	R:R:W210	R:R:Y206	5.79	Yes	Yes	1	6	7
177	R:R:L207	R:R:L278	5.54	No	No	1	6	6
178	R:R:V208	R:R:V282	4.81	No	No	0	4	5
179	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
180	R:R:F267	R:R:N214	6.04	Yes	Yes	1	9	7
181	R:R:N214	R:R:W271	14.69	Yes	Yes	1	7	8
182	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
183	R:R:F218	R:R:V222	7.87	No	No	0	5	4
184	R:R:F218	R:R:F267	11.79	No	Yes	0	5	9
185	R:R:F267	R:R:M221	6.22	Yes	No	0	9	9
186	R:R:V260	R:R:Y225	7.57	No	Yes	0	8	9
187	R:R:V263	R:R:Y225	7.57	No	Yes	0	8	9
188	R:R:L264	R:R:Y225	4.69	No	Yes	0	7	9
189	R:R:F229	R:R:M253	7.46	No	No	0	6	7
190	R:R:F229	R:R:L256	7.31	No	No	0	6	7
191	R:R:F229	R:R:L257	9.74	No	No	0	6	7
192	R:R:R235	R:R:Y231	17.49	No	No	0	7	6
193	R:R:L256	R:R:V232	4.47	No	No	0	7	7
194	R:R:M237	R:R:R233	9.93	No	No	0	5	5
195	R:R:M253	R:R:R233	3.72	No	No	0	7	5
196	R:R:D251	R:R:M253	8.32	No	No	0	5	7
197	R:R:R314	R:R:S255	10.54	No	No	0	7	7
198	R:R:T259	R:R:Y313	4.99	No	No	7	8	5
199	R:R:R314	R:R:T259	12.94	No	No	7	7	8
200	R:R:I262	R:R:Y313	7.25	No	No	0	6	5
201	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
202	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
203	R:R:I268	R:R:T272	6.08	No	No	0	6	5
204	R:R:C270	R:R:N303	7.87	No	No	0	9	9
205	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
206	R:R:N303	R:R:W271	9.04	No	Yes	0	9	8
207	R:R:P273	R:R:T272	3.5	No	No	0	9	5
208	R:R:F296	R:R:P273	8.67	No	No	0	5	9
209	R:R:L299	R:R:P273	8.21	No	No	0	7	9
210	R:R:F296	R:R:L277	8.53	No	No	0	5	4
211	R:R:C284	R:R:P285	3.77	No	No	0	4	3
212	R:R:C284	R:R:C287	7.28	No	No	0	4	5
213	R:R:F295	R:R:Y292	8.25	No	No	0	4	3
214	R:R:F302	R:R:M306	13.68	No	No	0	5	6
215	R:R:N303	R:R:N307	5.45	No	Yes	0	9	9
216	R:R:I310	R:R:Y311	4.84	No	Yes	0	8	9
217	R:R:M318	R:R:S312	6.13	Yes	No	0	8	7
218	R:R:R314	R:R:Y313	15.43	No	No	7	7	5
219	R:R:D315	R:R:M318	9.7	Yes	Yes	3	8	8
220	R:R:E317	R:R:K316	4.05	No	No	0	7	5
221	R:R:F322	R:R:M318	4.98	No	Yes	0	6	8
222	R:R:A175	R:R:T133	3.36	No	No	0	8	6
223	R:R:A305	R:R:I63	3.25	No	No	0	7	8
224	R:R:A89	R:R:M71	3.22	No	No	0	7	7
225	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
226	R:R:T47	R:R:V48	3.17	No	No	0	5	3
227	R:R:C287	R:R:L280	3.17	No	No	0	5	5
228	R:R:A94	R:R:N138	3.13	No	Yes	0	8	8
229	R:R:A291	R:R:D288	3.09	No	No	0	2	1
230	R:R:I181	R:R:V177	3.07	No	No	0	5	4
231	R:R:I212	R:R:V208	3.07	No	No	0	4	4
232	R:R:M174	R:R:V177	3.04	No	No	0	4	4
233	R:R:M198	R:R:V289	3.04	Yes	No	0	3	4
234	R:R:L140	R:R:V220	2.98	No	No	0	7	5
235	R:R:L280	R:R:V289	2.98	No	No	0	5	4
236	R:R:N77	R:R:V76	2.96	No	No	0	6	5
237	R:R:L116	R:R:T120	2.95	Yes	Yes	1	6	4
238	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
239	R:R:A42	R:R:H40	2.93	No	No	0	4	2
240	R:R:K258	R:R:M254	2.88	No	No	0	7	5
241	R:R:I144	R:R:L224	2.85	No	No	0	6	6
242	R:R:E44	R:R:T43	2.82	No	No	0	1	3
243	R:R:C270	R:R:F302	2.79	No	No	0	9	5
244	R:R:L298	R:R:L55	2.77	No	No	0	6	4
245	R:R:A305	R:R:F62	2.77	No	No	0	7	4
246	R:R:D288	R:R:L290	2.71	No	No	0	1	3
247	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
248	R:R:F33	R:R:V118	2.62	Yes	No	0	6	2
249	R:R:F213	R:R:V216	2.62	No	No	0	5	4
250	R:R:D315	R:R:E317	2.6	Yes	No	0	8	7
251	R:R:A300	R:R:W271	2.59	No	Yes	0	7	8
252	R:R:F107	R:R:I57	2.51	No	No	0	5	4
253	R:R:F103	R:R:I61	2.51	No	No	0	6	4
254	R:R:F96	R:R:L68	2.44	Yes	No	0	7	4
255	L:L:?1	R:R:G274	2.41	Yes	No	0	0	5
256	R:R:Q234	R:R:R233	2.34	No	No	0	4	5
257	R:R:Q234	R:R:R238	2.34	No	No	0	4	5
258	R:R:H81	R:R:R78	2.26	No	No	0	8	6
259	R:R:A66	R:R:P308	1.87	No	No	0	8	9
260	R:R:G54	R:R:T58	1.82	No	No	0	4	5
261	R:R:G110	R:R:T109	1.82	No	No	0	5	5
262	R:R:G179	R:R:T130	1.82	No	No	0	7	6
263	R:R:G54	R:R:I57	1.76	No	No	0	4	4
264	R:R:G265	R:R:I268	1.76	No	No	0	4	6
265	R:R:A31	R:R:S29	1.71	No	No	0	2	4
266	R:R:C283	R:R:V282	1.71	No	No	0	4	5
267	R:R:A180	R:R:V184	1.7	No	No	0	4	5
268	R:R:M159	R:R:P83	1.68	No	Yes	0	6	6
269	R:R:C24	R:R:I189	1.64	No	No	0	5	3
270	R:R:C270	R:R:I269	1.64	No	No	0	9	5
271	R:R:S49	R:R:V48	1.62	No	No	0	1	3
272	R:R:A266	R:R:I310	1.62	No	No	0	6	8
273	R:R:A93	R:R:M71	1.61	No	No	0	6	7
274	R:R:S119	R:R:T117	1.6	No	No	1	1	6
275	R:R:S119	R:R:T120	1.6	No	Yes	1	1	4
276	R:R:V150	R:R:V232	1.6	No	No	0	8	7
277	R:R:V164	R:R:V165	1.6	Yes	No	0	7	1
278	R:R:V166	R:R:V167	1.6	No	No	0	3	6
279	R:R:V166	R:R:V170	1.6	No	No	0	3	3
280	R:R:V219	R:R:V220	1.6	No	No	0	3	5
281	R:R:V260	R:R:V261	1.6	No	No	0	8	5
282	R:R:T236	R:R:V232	1.59	No	No	0	5	7
283	R:R:T259	R:R:V263	1.59	No	No	0	8	8
284	R:R:T272	R:R:V276	1.59	No	No	0	5	6
285	R:R:C283	R:R:L279	1.59	No	No	0	4	6
286	R:R:A211	R:R:L275	1.58	No	No	0	4	6
287	R:R:A42	R:R:N46	1.56	No	No	0	4	2
288	R:R:I212	R:R:V216	1.54	No	No	0	4	4
289	R:R:M174	R:R:V170	1.52	No	No	0	4	3
290	R:R:L122	R:R:S183	1.5	No	No	0	5	6
291	R:R:L123	R:R:T120	1.47	No	Yes	0	4	4
292	R:R:I309	R:R:M306	1.46	No	No	0	7	6
293	R:R:G185	R:R:W186	1.41	No	No	0	5	6
294	R:R:K258	R:R:L257	1.41	No	No	0	7	7
295	R:R:L65	R:R:L68	1.38	No	No	0	4	4
296	R:R:L65	R:R:L69	1.38	No	No	0	4	7
297	R:R:C24	R:R:Y26	1.34	No	No	0	5	4
298	R:R:H147	R:R:I148	1.33	Yes	No	0	7	5
299	R:R:R162	R:R:S160	1.32	No	No	0	5	8
300	R:R:F322	R:R:S319	1.32	No	No	0	6	8
301	R:R:R162	R:R:V166	1.31	No	No	0	5	3
302	R:R:E193	R:R:N194	1.31	No	No	0	4	3
303	R:R:M153	R:R:R235	1.24	No	No	0	7	7
304	R:R:I74	R:R:Y75	1.21	No	No	0	7	3
305	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
306	R:R:E193	R:R:R36	1.16	No	No	0	4	3
307	R:R:F80	R:R:R79	1.07	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.90077	13	1	0
2	R:R:E28	13.2275	4	4	4
3	R:R:F33	11.478	5	4	6
4	R:R:Y34	5.656	5	0	6
5	R:R:N67	4.9825	4	0	9
6	R:R:F80	8.18	6	3	8
7	R:R:P83	4.0075	4	0	6
8	R:R:Y85	9.6625	4	3	9
9	R:R:L91	5.244	5	2	9
10	R:R:D95	5.52	5	2	9
11	R:R:F96	5.2275	4	5	7
12	R:R:Y102	10.27	5	0	7
13	R:R:L116	3.8775	4	1	6
14	R:R:T120	2.6825	4	1	4
15	R:R:W121	8.28	5	1	9
16	R:R:R124	7.03833	6	1	6
17	R:R:Q125	9.46	4	1	4
18	R:R:D129	7.0525	4	1	5
19	R:R:L132	5.63	4	1	7
20	R:R:V136	5.53	4	1	8
21	R:R:N138	8.385	4	0	8
22	R:R:H147	9.384	5	6	7
23	R:R:F151	13.1275	4	6	6
24	R:R:V164	3.79	4	0	7
25	R:R:M178	4.544	5	1	5
26	R:R:M198	7.788	5	0	3
27	R:R:Y202	6.08	7	1	4
28	R:R:Y206	8.86333	6	1	7
29	R:R:W210	5.17333	6	1	6
30	R:R:N214	9.75	4	1	7
31	R:R:Y225	6.618	5	0	9
32	R:R:F267	9.328	5	1	9
33	R:R:W271	8.06	8	1	8
34	R:R:N307	7.1575	4	2	9
35	R:R:Y311	6.28167	6	2	9
36	R:R:D315	7.1675	4	3	8
37	R:R:M318	6.21667	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R124	32.0642	7.72	Yes	Yes	1	0	6
2	R:R:R124	R:R:W121	19.9582	7	Yes	Yes	1	6	9
3	R:R:L201	R:R:W121	34.9295	10.25	No	Yes	0	1	9
4	R:R:I189	R:R:L201	10.5688	4.28	No	No	0	3	1
5	L:L:?1	R:R:Q125	20.1495	7.52	Yes	Yes	1	0	4
6	R:R:Q125	R:R:W121	22.3631	15.33	Yes	Yes	1	4	9
7	R:R:F33	R:R:L201	22.9475	20.7	Yes	No	0	6	1
8	R:R:F33	R:R:I192	10.5688	8.79	Yes	No	0	6	1
9	L:L:?1	R:R:K39	11.4366	7.96	Yes	No	0	0	8
10	R:R:K39	R:R:Y34	10.4342	11.94	No	Yes	0	8	6
11	R:R:C60	R:R:Y102	14.61	5.38	No	Yes	0	6	7
12	R:R:C60	R:R:F103	12.9985	6.98	No	No	0	6	6
13	L:L:?1	R:R:W210	80.5058	6.43	Yes	Yes	1	0	6
14	R:R:L132	R:R:S131	11.2099	4.5	Yes	No	0	7	6
15	R:R:A98	R:R:S131	10.5865	3.42	No	No	0	8	6
16	R:R:A98	R:R:S304	10.328	3.42	No	No	0	8	9
17	R:R:W210	R:R:W271	92.6472	4.69	Yes	Yes	1	6	8
18	R:R:N303	R:R:W271	100	9.04	No	Yes	0	9	8
19	R:R:N303	R:R:N307	98.2574	5.45	No	Yes	0	9	9
20	R:R:D95	R:R:N307	69.3065	8.08	Yes	Yes	2	9	9
21	R:R:D95	R:R:N67	85.9177	6.73	Yes	Yes	0	9	9
22	R:R:A92	R:R:N67	77.9592	4.69	No	Yes	0	9	9
23	R:R:A92	R:R:V70	77.134	3.39	No	No	0	9	9
24	R:R:M318	R:R:V70	76.2839	4.56	Yes	No	0	8	9
25	R:R:F80	R:R:M318	37.5753	8.71	Yes	Yes	3	8	8
26	R:R:F80	R:R:Y85	32.5175	18.57	Yes	Yes	3	8	9
27	R:R:I74	R:R:Y85	11.6845	7.25	No	Yes	0	7	9
28	R:R:D315	R:R:M318	35.2554	9.7	Yes	Yes	3	8	8
29	R:R:D315	R:R:Y85	32.2165	9.2	Yes	Yes	3	8	9
30	R:R:I84	R:R:Y85	51.8063	3.63	No	Yes	0	8	9
31	R:R:E145	R:R:I84	49.6033	12.3	No	No	0	8	8
32	R:R:E145	R:R:P83	29.3441	4.72	No	Yes	0	8	6
33	R:R:P83	R:R:V164	13.8804	5.3	Yes	Yes	0	6	7
34	R:R:V164	R:R:Y86	18.3998	3.79	Yes	No	0	7	4
35	R:R:E145	R:R:L87	18.2865	6.63	No	No	0	8	8
36	R:R:L87	R:R:V164	13.7742	4.47	No	Yes	0	8	7
37	R:R:L139	R:R:N307	20.4293	10.98	No	Yes	2	8	9
38	R:R:L139	R:R:Y311	23.075	3.52	No	Yes	2	8	9
39	R:R:L91	R:R:N307	15.329	4.12	Yes	Yes	2	9	9
40	R:R:L91	R:R:N138	14.4471	8.24	Yes	Yes	0	9	8
41	R:R:E301	R:R:L132	17.3585	6.63	No	Yes	0	7	7
42	R:R:E301	R:R:Y102	16.303	23.57	No	Yes	0	7	7
43	R:R:W210	R:R:Y206	18.7682	5.79	Yes	Yes	1	6	7
44	R:R:M178	R:R:W210	11.6137	4.65	Yes	Yes	1	5	6
45	R:R:V136	R:R:W271	46.8832	4.9	Yes	Yes	1	8	8
46	R:R:T217	R:R:V136	46.9753	4.76	No	Yes	0	7	8
47	R:R:L140	R:R:T217	45.9942	5.9	No	No	0	7	7
48	R:R:I144	R:R:L140	43.0084	7.14	No	No	0	6	7
49	R:R:I142	R:R:L91	11.4932	4.28	No	Yes	2	8	9
50	R:R:V263	R:R:Y311	15.0103	6.31	No	Yes	0	8	9
51	R:R:I144	R:R:L224	41.999	2.85	No	No	0	6	6
52	R:R:H147	R:R:L224	40.9825	11.57	Yes	No	0	7	6
53	R:R:F151	R:R:H147	20.5497	20.36	Yes	Yes	6	6	7
54	R:R:H147	R:R:I228	17.2522	5.3	Yes	No	0	7	9
55	R:R:M159	R:R:P83	11.263	1.68	No	Yes	0	6	6
56	R:R:F151	R:R:V150	16.2464	3.93	Yes	No	0	6	8
57	R:R:I228	R:R:V150	16.1366	9.22	No	No	0	9	8
58	R:R:F213	R:R:M178	10.7069	4.98	No	Yes	0	5	5
59	R:R:W186	R:R:Y206	13.9371	3.86	No	Yes	0	6	7
60	L:L:?1	R:R:E293	29.0076	24.32	Yes	No	0	0	4
61	R:R:E293	R:R:M198	27.8707	14.89	No	Yes	0	4	3
62	R:R:L277	R:R:M198	10.165	7.07	No	Yes	0	4	3
63	R:R:V150	R:R:V232	30.0772	1.6	No	No	0	8	7
64	R:R:L256	R:R:V232	25.5755	4.47	No	No	0	7	7
65	R:R:F229	R:R:L256	23.4327	7.31	No	No	0	6	7
66	R:R:F229	R:R:M253	14.139	7.46	No	No	0	6	7
67	R:R:L132	R:R:W271	12.6904	7.97	Yes	Yes	1	7	8
68	R:R:D95	R:R:L91	13.2641	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K39	7.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:T109	5.2	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L207	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:W210	6.43	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	24.32	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	16.61	1	Yes	No	0	6	0	1
R:R:K39	R:R:Y34	11.94	0	No	Yes	8	6	1	2
R:R:K294	R:R:V52	13.66	0	No	No	4	5	1	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	7.23	0	No	Yes	5	6	2	1
R:R:L116	R:R:W121	3.42	1	Yes	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	Yes	Yes	6	6	2	1
R:R:R124	R:R:W121	7	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	Yes	Yes	4	9	1	2
R:R:L122	R:R:Y202	4.69	0	No	Yes	5	4	2	1
R:R:Q125	R:R:R124	9.35	1	Yes	Yes	4	6	1	1
R:R:Q125	R:R:Y202	5.64	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	8.05	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	10.34	1	Yes	Yes	5	7	1	2
R:R:L132	R:R:W210	3.42	1	Yes	Yes	7	6	2	1
R:R:L132	R:R:W271	7.97	1	Yes	Yes	7	8	2	2
R:R:M178	R:R:T133	4.52	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	4.65	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	9.74	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	23.64	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	0	No	Yes	4	3	1	2
R:R:Y202	R:R:Y206	5.96	1	Yes	Yes	4	7	1	2
R:R:L207	R:R:Y202	3.52	1	No	Yes	6	4	1	1
R:R:W210	R:R:Y206	5.79	1	Yes	Yes	6	7	1	2
R:R:L207	R:R:L278	5.54	1	No	No	6	6	1	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:G274	2.41	1	Yes	No	0	5	0	1
R:R:G110	R:R:T109	1.82	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	274
Number of Links	307
Number of Hubs	37
Number of Links mediated by Hubs	146
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	61757
Length Of Smallest Path	3
Average Path Length	13.9642
Length of Longest Path	32
Minimum Path Strength	1.235
Average Path Strength	6.98797
Maximum Path Strength	20.845
Minimum Path Correlation	0.7
Average Path Correlation	0.926398
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.973
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2759
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • ion binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • small molecule binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • protein binding • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • protein-containing complex localization • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • glutamatergic synapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • dendritic shaft • plasma membrane bounded cell projection • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU8_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	10.1016/j.jsb.2024.108164
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	10.1038/s41467-022-33121-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	10.1038/s41467-022-28417-2
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	10.1016/j.cell.2015.06.002

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