psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K39	7.96	Yes	No	0	0	8
2	L:L:?1	R:R:T109	5.2	Yes	No	0	0	5
3	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
5	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
7	L:L:?1	R:R:L207	3.91	Yes	No	1	0	6
8	L:L:?1	R:R:W210	6.43	Yes	Yes	1	0	6
9	L:L:?1	R:R:L278	3.91	Yes	No	1	0	6
10	L:L:?1	R:R:E293	24.32	Yes	No	0	0	4
11	L:L:?1	R:R:K294	6.97	Yes	No	0	0	4
12	L:L:?1	R:R:L297	16.61	Yes	No	0	0	6
13	R:R:C190	R:R:C24	7.28	No	No	0	3	5
14	R:R:F25	R:R:N27	6.04	No	No	4	7	8
15	R:R:E28	R:R:F25	5.83	Yes	No	4	4	7
16	R:R:E28	R:R:N27	3.94	Yes	No	4	4	8
17	R:R:E28	R:R:F32	22.15	Yes	No	4	4	2
18	R:R:E28	R:R:F33	20.99	Yes	Yes	4	4	6
19	R:R:I30	R:R:L116	4.28	No	Yes	0	6	6
20	R:R:F32	R:R:F33	4.29	No	Yes	4	2	6
21	R:R:F33	R:R:I192	8.79	Yes	No	0	6	1
22	R:R:F33	R:R:L201	20.7	Yes	No	0	6	1
23	R:R:K39	R:R:Y34	11.94	No	Yes	0	8	6
24	R:R:L41	R:R:Y34	3.52	No	Yes	0	2	6
25	R:R:T113	R:R:Y34	7.49	No	Yes	0	5	6
26	R:R:P200	R:R:Y34	4.17	No	Yes	0	6	6
27	R:R:I192	R:R:R36	8.77	No	No	0	1	3
28	R:R:G38	R:R:S37	3.71	No	No	0	4	7
29	R:R:P200	R:R:S37	3.56	No	No	0	6	7
30	R:R:L41	R:R:T43	5.9	No	No	0	2	3
31	R:R:L41	R:R:R114	9.72	No	No	0	2	6
32	R:R:P111	R:R:W45	20.27	No	No	0	4	1
33	R:R:N112	R:R:W45	5.65	No	No	0	4	1
34	R:R:N46	R:R:S49	8.94	No	No	0	2	1
35	R:R:K50	R:R:M53	5.76	No	No	0	3	4
36	R:R:K294	R:R:V52	13.66	No	No	0	4	5
37	R:R:G54	R:R:M53	5.24	No	No	0	4	4
38	R:R:G56	R:R:M106	3.49	No	No	0	6	6
39	R:R:F103	R:R:I57	5.02	No	No	0	6	4
40	R:R:L298	R:R:V59	5.96	No	No	0	6	7
41	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
42	R:R:C60	R:R:F103	6.98	No	No	0	6	6
43	R:R:G99	R:R:I63	3.53	No	No	0	7	8
44	R:R:I63	R:R:S304	4.64	No	No	0	8	9
45	R:R:F96	R:R:M64	11.2	Yes	No	5	7	6
46	R:R:L100	R:R:M64	5.65	No	No	5	4	6
47	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
48	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
49	R:R:F96	R:R:N67	3.62	Yes	Yes	0	7	9
50	R:R:N67	R:R:P308	4.89	Yes	No	0	9	9
51	R:R:F322	R:R:L69	17.05	No	No	0	6	7
52	R:R:A92	R:R:V70	3.39	No	No	0	9	9
53	R:R:M318	R:R:V70	4.56	Yes	No	0	8	9
54	R:R:I74	R:R:Y85	7.25	No	Yes	0	7	9
55	R:R:A89	R:R:I74	4.87	No	No	0	7	7
56	R:R:F80	R:R:N77	9.67	Yes	No	3	8	6
57	R:R:N77	R:R:T321	7.31	No	No	3	6	7
58	R:R:F80	R:R:Y85	18.57	Yes	Yes	3	8	9
59	R:R:D315	R:R:F80	7.17	Yes	Yes	3	8	8
60	R:R:F80	R:R:M318	8.71	Yes	Yes	3	8	8
61	R:R:F80	R:R:T321	3.89	Yes	No	3	8	7
62	R:R:H81	R:R:Y86	10.89	No	No	0	8	4
63	R:R:F82	R:R:P83	4.33	No	Yes	0	7	6
64	R:R:E145	R:R:P83	4.72	No	Yes	0	8	6
65	R:R:P83	R:R:V164	5.3	Yes	Yes	0	6	7
66	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
67	R:R:E145	R:R:I84	12.3	No	No	0	8	8
68	R:R:D315	R:R:Y85	9.2	Yes	Yes	3	8	9
69	R:R:N161	R:R:Y86	15.12	No	No	0	3	4
70	R:R:V164	R:R:Y86	3.79	Yes	No	0	7	4
71	R:R:A141	R:R:L87	4.73	No	No	0	8	8
72	R:R:E145	R:R:L87	6.63	No	No	0	8	8
73	R:R:L87	R:R:V164	4.47	No	Yes	0	8	7
74	R:R:M88	R:R:Y311	7.18	No	Yes	0	8	9
75	R:R:N138	R:R:N90	12.26	Yes	No	0	8	9
76	R:R:I168	R:R:N90	14.16	No	No	0	8	9
77	R:R:N90	R:R:W172	6.78	No	No	0	9	9
78	R:R:D95	R:R:L91	5.43	Yes	Yes	2	9	9
79	R:R:L91	R:R:N138	8.24	Yes	Yes	0	9	8
80	R:R:L139	R:R:L91	4.15	No	Yes	2	8	9
81	R:R:I142	R:R:L91	4.28	No	Yes	2	8	9
82	R:R:L91	R:R:N307	4.12	Yes	Yes	2	9	9
83	R:R:D95	R:R:S304	4.42	Yes	No	0	9	9
84	R:R:D95	R:R:N307	8.08	Yes	Yes	2	9	9
85	R:R:F96	R:R:L100	3.65	Yes	No	5	7	4
86	R:R:F97	R:R:T130	3.89	No	No	0	7	6
87	R:R:F97	R:R:W172	6.01	No	No	0	7	9
88	R:R:A98	R:R:S131	3.42	No	No	0	8	6
89	R:R:A98	R:R:S304	3.42	No	No	0	8	9
90	R:R:A101	R:R:S131	3.42	No	No	0	5	6
91	R:R:M106	R:R:Y102	5.99	No	Yes	0	6	7
92	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
93	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
94	R:R:E301	R:R:Y102	23.57	No	Yes	0	7	7
95	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
96	R:R:L127	R:R:Y104	3.52	No	No	0	5	5
97	R:R:L105	R:R:R124	6.07	No	Yes	0	6	6
98	R:R:I128	R:R:L105	4.28	No	No	0	6	6
99	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
100	R:R:G110	R:R:P111	4.06	No	No	0	5	4
101	R:R:L116	R:R:W121	3.42	Yes	Yes	1	6	9
102	R:R:L116	R:R:R124	4.86	Yes	Yes	1	6	6
103	R:R:T117	R:R:T120	4.71	No	Yes	1	6	4
104	R:R:R124	R:R:W121	7	Yes	Yes	1	6	9
105	R:R:Q125	R:R:W121	15.33	Yes	Yes	1	4	9
106	R:R:P200	R:R:W121	5.4	No	Yes	0	6	9
107	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
108	R:R:L122	R:R:Y202	4.69	No	Yes	0	5	4
109	R:R:Q125	R:R:R124	9.35	Yes	Yes	1	4	6
110	R:R:Q125	R:R:Y202	5.64	Yes	Yes	1	4	4
111	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
112	R:R:D129	R:R:Y202	8.05	Yes	Yes	1	5	4
113	R:R:D129	R:R:Y206	10.34	Yes	Yes	1	5	7
114	R:R:I176	R:R:T130	4.56	No	No	0	3	6
115	R:R:L132	R:R:S131	4.5	Yes	No	0	7	6
116	R:R:L132	R:R:W210	3.42	Yes	Yes	1	7	6
117	R:R:L132	R:R:W271	7.97	Yes	Yes	1	7	8
118	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
119	R:R:M178	R:R:T133	4.52	Yes	No	1	5	6
120	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
121	R:R:A134	R:R:W172	3.89	No	No	0	7	9
122	R:R:N214	R:R:V136	5.91	Yes	Yes	1	7	8
123	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
124	R:R:F267	R:R:V136	6.55	Yes	Yes	1	9	8
125	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
126	R:R:A137	R:R:I171	4.87	No	No	0	5	7
127	R:R:I171	R:R:N138	9.91	No	Yes	0	7	8
128	R:R:L139	R:R:N307	10.98	No	Yes	2	8	9
129	R:R:L139	R:R:Y311	3.52	No	Yes	2	8	9
130	R:R:I144	R:R:L140	7.14	No	No	0	6	7
131	R:R:L140	R:R:T217	5.9	No	No	0	7	7
132	R:R:I142	R:R:R146	3.76	No	No	2	8	9
133	R:R:I142	R:R:Y311	9.67	No	Yes	2	8	9
134	R:R:A143	R:R:Y225	4	No	Yes	0	8	9
135	R:R:R146	R:R:Y225	9.26	No	Yes	0	9	9
136	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
137	R:R:F151	R:R:H147	20.36	Yes	Yes	6	6	7
138	R:R:H147	R:R:L224	11.57	Yes	No	0	7	6
139	R:R:H147	R:R:H227	8.36	Yes	No	6	7	5
140	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
141	R:R:R152	R:R:T149	7.76	No	No	0	5	8
142	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
143	R:R:I228	R:R:V150	9.22	No	No	0	9	8
144	R:R:F151	R:R:H227	15.84	Yes	No	6	6	5
145	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
146	R:R:R152	R:R:T157	5.17	No	No	0	5	4
147	R:R:M159	R:R:R152	4.96	No	No	0	6	5
148	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
149	R:R:H156	R:R:L155	9	No	No	0	4	8
150	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
151	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
152	R:R:M178	R:R:W210	4.65	Yes	Yes	1	5	6
153	R:R:F213	R:R:M178	4.98	No	Yes	0	5	5
154	R:R:I181	R:R:P182	3.39	No	No	0	5	6
155	R:R:P182	R:R:Y202	9.74	No	Yes	1	6	4
156	R:R:P182	R:R:Y206	23.64	No	Yes	1	6	7
157	R:R:G185	R:R:V184	3.68	No	No	0	5	5
158	R:R:S205	R:R:W186	8.65	No	No	0	5	6
159	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
160	R:R:I189	R:R:N187	7.08	No	No	0	3	6
161	R:R:C188	R:R:C195	7.28	No	No	0	5	9
162	R:R:I189	R:R:L201	4.28	No	No	0	3	1
163	R:R:D191	R:R:N194	16.16	No	No	0	4	3
164	R:R:C195	R:R:S203	3.44	No	No	0	9	5
165	R:R:A199	R:R:S196	3.42	No	No	0	4	5
166	R:R:D281	R:R:S196	4.42	No	No	0	4	5
167	R:R:D281	R:R:N197	13.46	No	No	0	4	5
168	R:R:L277	R:R:M198	7.07	No	Yes	0	4	3
169	R:R:D281	R:R:M198	9.7	No	Yes	0	4	3
170	R:R:L290	R:R:M198	4.24	No	Yes	0	3	3
171	R:R:E293	R:R:M198	14.89	No	Yes	0	4	3
172	R:R:Y202	R:R:Y206	5.96	Yes	Yes	1	4	7
173	R:R:L207	R:R:Y202	3.52	No	Yes	1	6	4
174	R:R:S203	R:R:S205	4.89	No	No	0	5	5
175	R:R:D204	R:R:V282	8.76	No	No	0	4	5
176	R:R:W210	R:R:Y206	5.79	Yes	Yes	1	6	7
177	R:R:L207	R:R:L278	5.54	No	No	1	6	6
178	R:R:V208	R:R:V282	4.81	No	No	0	4	5
179	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
180	R:R:F267	R:R:N214	6.04	Yes	Yes	1	9	7
181	R:R:N214	R:R:W271	14.69	Yes	Yes	1	7	8
182	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
183	R:R:F218	R:R:V222	7.87	No	No	0	5	4
184	R:R:F218	R:R:F267	11.79	No	Yes	0	5	9
185	R:R:F267	R:R:M221	6.22	Yes	No	0	9	9
186	R:R:V260	R:R:Y225	7.57	No	Yes	0	8	9
187	R:R:V263	R:R:Y225	7.57	No	Yes	0	8	9
188	R:R:L264	R:R:Y225	4.69	No	Yes	0	7	9
189	R:R:F229	R:R:M253	7.46	No	No	0	6	7
190	R:R:F229	R:R:L256	7.31	No	No	0	6	7
191	R:R:F229	R:R:L257	9.74	No	No	0	6	7
192	R:R:R235	R:R:Y231	17.49	No	No	0	7	6
193	R:R:L256	R:R:V232	4.47	No	No	0	7	7
194	R:R:M237	R:R:R233	9.93	No	No	0	5	5
195	R:R:M253	R:R:R233	3.72	No	No	0	7	5
196	R:R:D251	R:R:M253	8.32	No	No	0	5	7
197	R:R:R314	R:R:S255	10.54	No	No	0	7	7
198	R:R:T259	R:R:Y313	4.99	No	No	7	8	5
199	R:R:R314	R:R:T259	12.94	No	No	7	7	8
200	R:R:I262	R:R:Y313	7.25	No	No	0	6	5
201	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
202	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
203	R:R:I268	R:R:T272	6.08	No	No	0	6	5
204	R:R:C270	R:R:N303	7.87	No	No	0	9	9
205	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
206	R:R:N303	R:R:W271	9.04	No	Yes	0	9	8
207	R:R:P273	R:R:T272	3.5	No	No	0	9	5
208	R:R:F296	R:R:P273	8.67	No	No	0	5	9
209	R:R:L299	R:R:P273	8.21	No	No	0	7	9
210	R:R:F296	R:R:L277	8.53	No	No	0	5	4
211	R:R:C284	R:R:P285	3.77	No	No	0	4	3
212	R:R:C284	R:R:C287	7.28	No	No	0	4	5
213	R:R:F295	R:R:Y292	8.25	No	No	0	4	3
214	R:R:F302	R:R:M306	13.68	No	No	0	5	6
215	R:R:N303	R:R:N307	5.45	No	Yes	0	9	9
216	R:R:I310	R:R:Y311	4.84	No	Yes	0	8	9
217	R:R:M318	R:R:S312	6.13	Yes	No	0	8	7
218	R:R:R314	R:R:Y313	15.43	No	No	7	7	5
219	R:R:D315	R:R:M318	9.7	Yes	Yes	3	8	8
220	R:R:E317	R:R:K316	4.05	No	No	0	7	5
221	R:R:F322	R:R:M318	4.98	No	Yes	0	6	8
222	R:R:A175	R:R:T133	3.36	No	No	0	8	6
223	R:R:A305	R:R:I63	3.25	No	No	0	7	8
224	R:R:A89	R:R:M71	3.22	No	No	0	7	7
225	R:R:A73	R:R:M318	3.22	No	Yes	0	7	8
226	R:R:T47	R:R:V48	3.17	No	No	0	5	3
227	R:R:C287	R:R:L280	3.17	No	No	0	5	5
228	R:R:A94	R:R:N138	3.13	No	Yes	0	8	8
229	R:R:A291	R:R:D288	3.09	No	No	0	2	1
230	R:R:I181	R:R:V177	3.07	No	No	0	5	4
231	R:R:I212	R:R:V208	3.07	No	No	0	4	4
232	R:R:M174	R:R:V177	3.04	No	No	0	4	4
233	R:R:M198	R:R:V289	3.04	Yes	No	0	3	4
234	R:R:L140	R:R:V220	2.98	No	No	0	7	5
235	R:R:L280	R:R:V289	2.98	No	No	0	5	4
236	R:R:N77	R:R:V76	2.96	No	No	0	6	5
237	R:R:L116	R:R:T120	2.95	Yes	Yes	1	6	4
238	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
239	R:R:A42	R:R:H40	2.93	No	No	0	4	2
240	R:R:K258	R:R:M254	2.88	No	No	0	7	5
241	R:R:I144	R:R:L224	2.85	No	No	0	6	6
242	R:R:E44	R:R:T43	2.82	No	No	0	1	3
243	R:R:C270	R:R:F302	2.79	No	No	0	9	5
244	R:R:L298	R:R:L55	2.77	No	No	0	6	4
245	R:R:A305	R:R:F62	2.77	No	No	0	7	4
246	R:R:D288	R:R:L290	2.71	No	No	0	1	3
247	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
248	R:R:F33	R:R:V118	2.62	Yes	No	0	6	2
249	R:R:F213	R:R:V216	2.62	No	No	0	5	4
250	R:R:D315	R:R:E317	2.6	Yes	No	0	8	7
251	R:R:A300	R:R:W271	2.59	No	Yes	0	7	8
252	R:R:F107	R:R:I57	2.51	No	No	0	5	4
253	R:R:F103	R:R:I61	2.51	No	No	0	6	4
254	R:R:F96	R:R:L68	2.44	Yes	No	0	7	4
255	L:L:?1	R:R:G274	2.41	Yes	No	0	0	5
256	R:R:Q234	R:R:R233	2.34	No	No	0	4	5
257	R:R:Q234	R:R:R238	2.34	No	No	0	4	5
258	R:R:H81	R:R:R78	2.26	No	No	0	8	6
259	R:R:A66	R:R:P308	1.87	No	No	0	8	9
260	R:R:G54	R:R:T58	1.82	No	No	0	4	5
261	R:R:G110	R:R:T109	1.82	No	No	0	5	5
262	R:R:G179	R:R:T130	1.82	No	No	0	7	6
263	R:R:G54	R:R:I57	1.76	No	No	0	4	4
264	R:R:G265	R:R:I268	1.76	No	No	0	4	6
265	R:R:A31	R:R:S29	1.71	No	No	0	2	4
266	R:R:C283	R:R:V282	1.71	No	No	0	4	5
267	R:R:A180	R:R:V184	1.7	No	No	0	4	5
268	R:R:M159	R:R:P83	1.68	No	Yes	0	6	6
269	R:R:C24	R:R:I189	1.64	No	No	0	5	3
270	R:R:C270	R:R:I269	1.64	No	No	0	9	5
271	R:R:S49	R:R:V48	1.62	No	No	0	1	3
272	R:R:A266	R:R:I310	1.62	No	No	0	6	8
273	R:R:A93	R:R:M71	1.61	No	No	0	6	7
274	R:R:S119	R:R:T117	1.6	No	No	1	1	6
275	R:R:S119	R:R:T120	1.6	No	Yes	1	1	4
276	R:R:V150	R:R:V232	1.6	No	No	0	8	7
277	R:R:V164	R:R:V165	1.6	Yes	No	0	7	1
278	R:R:V166	R:R:V167	1.6	No	No	0	3	6
279	R:R:V166	R:R:V170	1.6	No	No	0	3	3
280	R:R:V219	R:R:V220	1.6	No	No	0	3	5
281	R:R:V260	R:R:V261	1.6	No	No	0	8	5
282	R:R:T236	R:R:V232	1.59	No	No	0	5	7
283	R:R:T259	R:R:V263	1.59	No	No	0	8	8
284	R:R:T272	R:R:V276	1.59	No	No	0	5	6
285	R:R:C283	R:R:L279	1.59	No	No	0	4	6
286	R:R:A211	R:R:L275	1.58	No	No	0	4	6
287	R:R:A42	R:R:N46	1.56	No	No	0	4	2
288	R:R:I212	R:R:V216	1.54	No	No	0	4	4
289	R:R:M174	R:R:V170	1.52	No	No	0	4	3
290	R:R:L122	R:R:S183	1.5	No	No	0	5	6
291	R:R:L123	R:R:T120	1.47	No	Yes	0	4	4
292	R:R:I309	R:R:M306	1.46	No	No	0	7	6
293	R:R:G185	R:R:W186	1.41	No	No	0	5	6
294	R:R:K258	R:R:L257	1.41	No	No	0	7	7
295	R:R:L65	R:R:L68	1.38	No	No	0	4	4
296	R:R:L65	R:R:L69	1.38	No	No	0	4	7
297	R:R:C24	R:R:Y26	1.34	No	No	0	5	4
298	R:R:H147	R:R:I148	1.33	Yes	No	0	7	5
299	R:R:R162	R:R:S160	1.32	No	No	0	5	8
300	R:R:F322	R:R:S319	1.32	No	No	0	6	8
301	R:R:R162	R:R:V166	1.31	No	No	0	5	3
302	R:R:E193	R:R:N194	1.31	No	No	0	4	3
303	R:R:M153	R:R:R235	1.24	No	No	0	7	7
304	R:R:I74	R:R:Y75	1.21	No	No	0	7	3
305	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
306	R:R:E193	R:R:R36	1.16	No	No	0	4	3
307	R:R:F80	R:R:R79	1.07	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.90077	13	1	0
2	R:R:E28	13.2275	4	4	4
3	R:R:F33	11.478	5	4	6
4	R:R:Y34	5.656	5	0	6
5	R:R:N67	4.9825	4	0	9
6	R:R:F80	8.18	6	3	8
7	R:R:P83	4.0075	4	0	6
8	R:R:Y85	9.6625	4	3	9
9	R:R:L91	5.244	5	2	9
10	R:R:D95	5.52	5	2	9
11	R:R:F96	5.2275	4	5	7
12	R:R:Y102	10.27	5	0	7
13	R:R:L116	3.8775	4	1	6
14	R:R:T120	2.6825	4	1	4
15	R:R:W121	8.28	5	1	9
16	R:R:R124	7.03833	6	1	6
17	R:R:Q125	9.46	4	1	4
18	R:R:D129	7.0525	4	1	5
19	R:R:L132	5.63	4	1	7
20	R:R:V136	5.53	4	1	8
21	R:R:N138	8.385	4	0	8
22	R:R:H147	9.384	5	6	7
23	R:R:F151	13.1275	4	6	6
24	R:R:V164	3.79	4	0	7
25	R:R:M178	4.544	5	1	5
26	R:R:M198	7.788	5	0	3
27	R:R:Y202	6.08	7	1	4
28	R:R:Y206	8.86333	6	1	7
29	R:R:W210	5.17333	6	1	6
30	R:R:N214	9.75	4	1	7
31	R:R:Y225	6.618	5	0	9
32	R:R:F267	9.328	5	1	9
33	R:R:W271	8.06	8	1	8
34	R:R:N307	7.1575	4	2	9
35	R:R:Y311	6.28167	6	2	9
36	R:R:D315	7.1675	4	3	8
37	R:R:M318	6.21667	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R124	32.0642	7.72	Yes	Yes	1	0	6
2	R:R:R124	R:R:W121	19.9582	7	Yes	Yes	1	6	9
3	R:R:L201	R:R:W121	34.9295	10.25	No	Yes	0	1	9
4	R:R:I189	R:R:L201	10.5688	4.28	No	No	0	3	1
5	L:L:?1	R:R:Q125	20.1495	7.52	Yes	Yes	1	0	4
6	R:R:Q125	R:R:W121	22.3631	15.33	Yes	Yes	1	4	9
7	R:R:F33	R:R:L201	22.9475	20.7	Yes	No	0	6	1
8	R:R:F33	R:R:I192	10.5688	8.79	Yes	No	0	6	1
9	L:L:?1	R:R:K39	11.4366	7.96	Yes	No	0	0	8
10	R:R:K39	R:R:Y34	10.4342	11.94	No	Yes	0	8	6
11	R:R:C60	R:R:Y102	14.61	5.38	No	Yes	0	6	7
12	R:R:C60	R:R:F103	12.9985	6.98	No	No	0	6	6
13	L:L:?1	R:R:W210	80.5058	6.43	Yes	Yes	1	0	6
14	R:R:L132	R:R:S131	11.2099	4.5	Yes	No	0	7	6
15	R:R:A98	R:R:S131	10.5865	3.42	No	No	0	8	6
16	R:R:A98	R:R:S304	10.328	3.42	No	No	0	8	9
17	R:R:W210	R:R:W271	92.6472	4.69	Yes	Yes	1	6	8
18	R:R:N303	R:R:W271	100	9.04	No	Yes	0	9	8
19	R:R:N303	R:R:N307	98.2574	5.45	No	Yes	0	9	9
20	R:R:D95	R:R:N307	69.3065	8.08	Yes	Yes	2	9	9
21	R:R:D95	R:R:N67	85.9177	6.73	Yes	Yes	0	9	9
22	R:R:A92	R:R:N67	77.9592	4.69	No	Yes	0	9	9
23	R:R:A92	R:R:V70	77.134	3.39	No	No	0	9	9
24	R:R:M318	R:R:V70	76.2839	4.56	Yes	No	0	8	9
25	R:R:F80	R:R:M318	37.5753	8.71	Yes	Yes	3	8	8
26	R:R:F80	R:R:Y85	32.5175	18.57	Yes	Yes	3	8	9
27	R:R:I74	R:R:Y85	11.6845	7.25	No	Yes	0	7	9
28	R:R:D315	R:R:M318	35.2554	9.7	Yes	Yes	3	8	8
29	R:R:D315	R:R:Y85	32.2165	9.2	Yes	Yes	3	8	9
30	R:R:I84	R:R:Y85	51.8063	3.63	No	Yes	0	8	9
31	R:R:E145	R:R:I84	49.6033	12.3	No	No	0	8	8
32	R:R:E145	R:R:P83	29.3441	4.72	No	Yes	0	8	6
33	R:R:P83	R:R:V164	13.8804	5.3	Yes	Yes	0	6	7
34	R:R:V164	R:R:Y86	18.3998	3.79	Yes	No	0	7	4
35	R:R:E145	R:R:L87	18.2865	6.63	No	No	0	8	8
36	R:R:L87	R:R:V164	13.7742	4.47	No	Yes	0	8	7
37	R:R:L139	R:R:N307	20.4293	10.98	No	Yes	2	8	9
38	R:R:L139	R:R:Y311	23.075	3.52	No	Yes	2	8	9
39	R:R:L91	R:R:N307	15.329	4.12	Yes	Yes	2	9	9
40	R:R:L91	R:R:N138	14.4471	8.24	Yes	Yes	0	9	8
41	R:R:E301	R:R:L132	17.3585	6.63	No	Yes	0	7	7
42	R:R:E301	R:R:Y102	16.303	23.57	No	Yes	0	7	7
43	R:R:W210	R:R:Y206	18.7682	5.79	Yes	Yes	1	6	7
44	R:R:M178	R:R:W210	11.6137	4.65	Yes	Yes	1	5	6
45	R:R:V136	R:R:W271	46.8832	4.9	Yes	Yes	1	8	8
46	R:R:T217	R:R:V136	46.9753	4.76	No	Yes	0	7	8
47	R:R:L140	R:R:T217	45.9942	5.9	No	No	0	7	7
48	R:R:I144	R:R:L140	43.0084	7.14	No	No	0	6	7
49	R:R:I142	R:R:L91	11.4932	4.28	No	Yes	2	8	9
50	R:R:V263	R:R:Y311	15.0103	6.31	No	Yes	0	8	9
51	R:R:I144	R:R:L224	41.999	2.85	No	No	0	6	6
52	R:R:H147	R:R:L224	40.9825	11.57	Yes	No	0	7	6
53	R:R:F151	R:R:H147	20.5497	20.36	Yes	Yes	6	6	7
54	R:R:H147	R:R:I228	17.2522	5.3	Yes	No	0	7	9
55	R:R:M159	R:R:P83	11.263	1.68	No	Yes	0	6	6
56	R:R:F151	R:R:V150	16.2464	3.93	Yes	No	0	6	8
57	R:R:I228	R:R:V150	16.1366	9.22	No	No	0	9	8
58	R:R:F213	R:R:M178	10.7069	4.98	No	Yes	0	5	5
59	R:R:W186	R:R:Y206	13.9371	3.86	No	Yes	0	6	7
60	L:L:?1	R:R:E293	29.0076	24.32	Yes	No	0	0	4
61	R:R:E293	R:R:M198	27.8707	14.89	No	Yes	0	4	3
62	R:R:L277	R:R:M198	10.165	7.07	No	Yes	0	4	3
63	R:R:V150	R:R:V232	30.0772	1.6	No	No	0	8	7
64	R:R:L256	R:R:V232	25.5755	4.47	No	No	0	7	7
65	R:R:F229	R:R:L256	23.4327	7.31	No	No	0	6	7
66	R:R:F229	R:R:M253	14.139	7.46	No	No	0	6	7
67	R:R:L132	R:R:W271	12.6904	7.97	Yes	Yes	1	7	8
68	R:R:D95	R:R:L91	13.2641	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K39	7.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:T109	5.2	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L207	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:W210	6.43	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	24.32	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	16.61	1	Yes	No	0	6	0	1
R:R:K39	R:R:Y34	11.94	0	No	Yes	8	6	1	2
R:R:K294	R:R:V52	13.66	0	No	No	4	5	1	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	7.23	0	No	Yes	5	6	2	1
R:R:L116	R:R:W121	3.42	1	Yes	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	Yes	Yes	6	6	2	1
R:R:R124	R:R:W121	7	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	Yes	Yes	4	9	1	2
R:R:L122	R:R:Y202	4.69	0	No	Yes	5	4	2	1
R:R:Q125	R:R:R124	9.35	1	Yes	Yes	4	6	1	1
R:R:Q125	R:R:Y202	5.64	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	8.05	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	10.34	1	Yes	Yes	5	7	1	2
R:R:L132	R:R:W210	3.42	1	Yes	Yes	7	6	2	1
R:R:L132	R:R:W271	7.97	1	Yes	Yes	7	8	2	2
R:R:M178	R:R:T133	4.52	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	4.65	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	9.74	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	23.64	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	0	No	Yes	4	3	1	2
R:R:Y202	R:R:Y206	5.96	1	Yes	Yes	4	7	1	2
R:R:L207	R:R:Y202	3.52	1	No	Yes	6	4	1	1
R:R:W210	R:R:Y206	5.79	1	Yes	Yes	6	7	1	2
R:R:L207	R:R:L278	5.54	1	No	No	6	6	1	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:G274	2.41	1	Yes	No	0	5	0	1
R:R:G110	R:R:T109	1.82	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	274
Number of Links	307
Number of Hubs	37
Number of Links mediated by Hubs	146
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	61757
Length Of Smallest Path	3
Average Path Length	13.9642
Length of Longest Path	32
Minimum Path Strength	1.235
Average Path Strength	6.98797
Maximum Path Strength	20.845
Minimum Path Correlation	0.7
Average Path Correlation	0.926365
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.9701
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2759
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU8_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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