psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F25	R:R:Q23	19.91	No	No	0	7	3
2	R:R:C190	R:R:C24	7.28	No	No	0	3	5
3	R:R:E28	R:R:F25	3.5	No	No	0	4	7
4	R:R:E28	R:R:F32	33.81	No	No	0	4	2
5	R:R:F32	R:R:R36	7.48	No	No	0	2	3
6	R:R:F33	R:R:I192	3.77	No	No	0	6	1
7	R:R:F33	R:R:L201	20.7	No	No	0	6	1
8	R:R:K39	R:R:Y34	10.75	No	Yes	1	8	6
9	R:R:T113	R:R:Y34	7.49	No	Yes	0	5	6
10	R:R:P200	R:R:Y34	5.56	No	Yes	0	6	6
11	L:L:?1	R:R:Y34	3.31	Yes	Yes	1	0	6
12	R:R:I192	R:R:R36	6.26	No	No	0	1	3
13	R:R:G38	R:R:S37	3.71	No	No	0	4	7
14	L:L:?1	R:R:K39	8.96	Yes	No	1	0	8
15	R:R:L41	R:R:T43	4.42	No	No	0	2	3
16	R:R:L41	R:R:R114	4.86	No	No	0	2	6
17	R:R:E44	R:R:N46	3.94	No	No	0	1	2
18	R:R:P111	R:R:W45	17.57	No	No	0	4	1
19	R:R:N46	R:R:S49	8.94	No	No	0	2	1
20	R:R:K294	R:R:V52	13.66	No	No	0	4	5
21	R:R:G54	R:R:M53	3.49	No	No	0	4	4
22	R:R:F103	R:R:I57	6.28	No	Yes	0	6	4
23	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
24	R:R:C60	R:R:F103	6.98	No	No	0	6	6
25	R:R:I63	R:R:N67	4.25	Yes	Yes	0	8	9
26	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
27	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
28	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
29	R:R:F96	R:R:M64	11.2	No	No	0	7	6
30	R:R:L100	R:R:M64	5.65	No	No	0	4	6
31	R:R:A66	R:R:P308	3.74	No	No	0	8	9
32	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
33	R:R:D95	R:R:N67	8.08	Yes	Yes	0	9	9
34	R:R:N67	R:R:P308	6.52	Yes	No	0	9	9
35	R:R:F96	R:R:L68	4.87	No	No	0	7	4
36	R:R:A92	R:R:V70	3.39	No	No	0	9	9
37	R:R:M318	R:R:V70	4.56	Yes	No	0	8	9
38	R:R:A89	R:R:I74	6.5	No	No	0	7	7
39	R:R:F80	R:R:N77	9.67	Yes	No	3	8	6
40	R:R:N77	R:R:T321	7.31	No	No	3	6	7
41	R:R:F80	R:R:R79	8.55	Yes	No	0	8	6
42	R:R:F80	R:R:Y85	19.6	Yes	No	0	8	9
43	R:R:F80	R:R:M318	11.2	Yes	Yes	0	8	8
44	R:R:F80	R:R:T321	5.19	Yes	No	3	8	7
45	R:R:H81	R:R:Y86	19.6	No	No	0	8	4
46	R:R:F82	R:R:P83	4.33	No	No	0	7	6
47	R:R:P83	R:R:V164	5.3	No	Yes	0	6	7
48	R:R:I84	R:R:Y85	3.63	No	No	0	8	9
49	R:R:E145	R:R:I84	9.56	No	No	0	8	8
50	R:R:D315	R:R:Y85	5.75	No	No	0	8	9
51	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
52	R:R:V164	R:R:Y86	5.05	Yes	No	0	7	4
53	R:R:E145	R:R:L87	6.63	No	No	0	8	8
54	R:R:M88	R:R:Y311	7.18	No	Yes	0	8	9
55	R:R:N138	R:R:N90	12.26	No	No	0	8	9
56	R:R:I168	R:R:N90	12.74	No	No	0	8	9
57	R:R:N90	R:R:W172	6.78	No	Yes	0	9	9
58	R:R:D95	R:R:L91	5.43	Yes	Yes	0	9	9
59	R:R:L91	R:R:N138	6.87	Yes	No	0	9	8
60	R:R:L139	R:R:L91	5.54	Yes	Yes	2	8	9
61	R:R:I142	R:R:L91	4.28	No	Yes	2	8	9
62	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
63	R:R:D95	R:R:S304	5.89	Yes	No	0	9	9
64	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
65	R:R:F97	R:R:T130	3.89	No	No	0	7	6
66	R:R:F97	R:R:W172	5.01	No	Yes	0	7	9
67	R:R:A98	R:R:S131	3.42	No	No	0	8	6
68	R:R:A98	R:R:S304	3.42	No	No	0	8	9
69	R:R:A101	R:R:I128	3.25	No	No	0	5	6
70	R:R:A101	R:R:S131	3.42	No	No	0	5	6
71	R:R:M106	R:R:Y102	7.18	No	Yes	0	6	7
72	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
73	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
74	R:R:E301	R:R:Y102	25.81	No	Yes	0	7	7
75	R:R:F103	R:R:F107	5.36	No	No	0	6	5
76	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
77	R:R:L123	R:R:Y104	3.52	No	No	0	4	5
78	R:R:L105	R:R:R124	6.07	No	Yes	0	6	6
79	R:R:I128	R:R:L105	4.28	No	No	0	6	6
80	R:R:N108	R:R:R124	8.44	No	Yes	0	5	6
81	R:R:K294	R:R:T109	4.5	No	No	1	4	5
82	L:L:?1	R:R:T109	5.2	Yes	No	1	0	5
83	R:R:G110	R:R:P111	4.06	No	No	0	5	4
84	R:R:N112	R:R:R115	12.05	No	No	0	4	3
85	R:R:R124	R:R:T113	3.88	Yes	No	0	6	5
86	R:R:L116	R:R:W121	3.42	Yes	Yes	1	6	9
87	R:R:L116	R:R:R124	4.86	Yes	Yes	1	6	6
88	R:R:T117	R:R:T120	4.71	No	No	0	6	4
89	R:R:R124	R:R:W121	8	Yes	Yes	1	6	9
90	R:R:Q125	R:R:W121	16.43	Yes	Yes	1	4	9
91	R:R:P200	R:R:W121	4.05	No	Yes	0	6	9
92	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
93	R:R:Q125	R:R:R124	9.35	Yes	Yes	1	4	6
94	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
95	R:R:Q125	R:R:Y202	6.76	Yes	Yes	1	4	4
96	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
97	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
98	R:R:D129	R:R:Y202	9.2	Yes	Yes	1	5	4
99	R:R:D129	R:R:Y206	8.05	Yes	Yes	1	5	7
100	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
101	R:R:I176	R:R:T130	4.56	No	No	0	3	6
102	R:R:L132	R:R:W210	3.42	No	Yes	1	7	6
103	R:R:L132	R:R:W271	6.83	No	Yes	1	7	8
104	R:R:E301	R:R:L132	6.63	No	No	0	7	7
105	R:R:A175	R:R:T133	3.36	No	No	0	8	6
106	R:R:M178	R:R:T133	4.52	Yes	No	1	5	6
107	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
108	R:R:A134	R:R:W172	3.89	No	Yes	0	7	9
109	R:R:N214	R:R:V136	7.39	Yes	Yes	1	7	8
110	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
111	R:R:F267	R:R:V136	5.24	Yes	Yes	1	9	8
112	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
113	R:R:A137	R:R:I171	4.87	No	No	0	5	7
114	R:R:I171	R:R:N138	9.91	No	No	0	7	8
115	R:R:L139	R:R:N307	8.24	Yes	No	0	8	9
116	R:R:L139	R:R:Y311	3.52	Yes	Yes	2	8	9
117	R:R:I144	R:R:L140	7.14	No	Yes	0	6	7
118	R:R:L140	R:R:T217	5.9	Yes	No	0	7	7
119	R:R:A141	R:R:I171	3.25	No	No	0	8	7
120	R:R:I142	R:R:R146	3.76	No	No	2	8	9
121	R:R:I142	R:R:Y311	6.04	No	Yes	2	8	9
122	R:R:R146	R:R:Y225	9.26	No	No	0	9	9
123	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
124	R:R:F151	R:R:H147	15.84	Yes	Yes	4	6	7
125	R:R:H147	R:R:L224	5.14	Yes	No	0	7	6
126	R:R:H147	R:R:H227	9.55	Yes	No	4	7	5
127	R:R:H147	R:R:I228	3.98	Yes	No	0	7	9
128	R:R:R152	R:R:T149	5.17	No	No	0	5	8
129	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
130	R:R:I228	R:R:V150	7.68	No	No	0	9	8
131	R:R:F151	R:R:H227	15.84	Yes	No	4	6	5
132	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
133	R:R:R152	R:R:T157	11.64	No	No	0	5	4
134	R:R:M159	R:R:R152	3.72	No	No	0	6	5
135	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
136	R:R:H156	R:R:L155	9	No	No	0	4	8
137	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
138	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
139	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
140	R:R:I181	R:R:P182	3.39	No	No	0	5	6
141	R:R:P182	R:R:Y202	11.13	No	Yes	1	6	4
142	R:R:P182	R:R:Y206	18.08	No	Yes	1	6	7
143	R:R:G185	R:R:V184	3.68	No	No	0	5	5
144	R:R:S205	R:R:W186	8.65	No	No	0	5	6
145	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
146	R:R:I189	R:R:N187	8.5	Yes	No	0	3	6
147	R:R:C188	R:R:C195	7.28	No	No	0	5	9
148	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
149	R:R:E193	R:R:I192	4.1	No	No	0	4	1
150	R:R:A199	R:R:S196	3.42	No	No	0	4	5
151	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
152	R:R:D281	R:R:N197	10.77	Yes	No	0	4	5
153	R:R:L277	R:R:M198	7.07	No	No	0	4	3
154	R:R:D281	R:R:M198	11.09	Yes	No	0	4	3
155	R:R:E293	R:R:M198	14.89	No	No	0	4	3
156	R:R:A199	R:R:Y202	5.34	No	Yes	0	4	4
157	R:R:Y202	R:R:Y206	10.92	Yes	Yes	1	4	7
158	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
159	R:R:S203	R:R:S205	4.89	No	No	0	5	5
160	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
161	R:R:L207	R:R:L278	4.15	No	No	1	6	6
162	L:L:?1	R:R:L207	3.91	Yes	No	1	0	6
163	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
164	L:L:?1	R:R:W210	8.04	Yes	Yes	1	0	6
165	R:R:F213	R:R:T217	5.19	No	No	0	5	7
166	R:R:F267	R:R:N214	7.25	Yes	Yes	1	9	7
167	R:R:N214	R:R:W271	10.17	Yes	Yes	1	7	8
168	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
169	R:R:F218	R:R:V222	7.87	No	No	0	5	4
170	R:R:F218	R:R:F267	11.79	No	Yes	0	5	9
171	R:R:F218	R:R:I268	3.77	No	No	0	5	6
172	R:R:V260	R:R:Y225	5.05	No	No	0	8	9
173	R:R:V263	R:R:Y225	5.05	No	No	0	8	9
174	R:R:F229	R:R:L256	7.31	No	No	0	6	7
175	R:R:F229	R:R:L257	7.31	No	No	0	6	7
176	R:R:R235	R:R:Y231	14.4	No	No	0	7	6
177	R:R:L256	R:R:V232	4.47	No	No	0	7	7
178	R:R:M253	R:R:R233	4.96	Yes	No	0	7	5
179	R:R:M237	R:R:M253	4.33	No	Yes	0	5	7
180	R:R:D251	R:R:M253	4.16	No	Yes	0	5	7
181	R:R:R314	R:R:S255	7.91	Yes	No	0	7	7
182	R:R:T259	R:R:Y313	4.99	No	No	5	8	5
183	R:R:R314	R:R:T259	11.64	Yes	No	5	7	8
184	R:R:I262	R:R:Y313	7.25	No	No	0	6	5
185	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
186	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
187	R:R:I268	R:R:T272	6.08	No	No	0	6	5
188	R:R:C270	R:R:N303	9.45	No	No	0	9	9
189	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
190	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
191	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
192	R:R:P273	R:R:T272	3.5	Yes	No	0	9	5
193	R:R:F296	R:R:P273	8.67	No	Yes	0	5	9
194	R:R:L299	R:R:P273	3.28	No	Yes	0	7	9
195	R:R:F296	R:R:L277	8.53	No	No	0	5	4
196	L:L:?1	R:R:L278	6.84	Yes	No	1	0	6
197	R:R:L280	R:R:V289	4.47	No	Yes	0	5	4
198	R:R:D281	R:R:V289	4.38	Yes	Yes	0	4	4
199	R:R:C284	R:R:P285	3.77	No	No	0	4	3
200	R:R:C284	R:R:C287	7.28	No	No	0	4	5
201	L:L:?1	R:R:E293	23.38	Yes	No	0	0	4
202	L:L:?1	R:R:K294	6.97	Yes	No	1	0	4
203	L:L:?1	R:R:L297	16.61	Yes	No	0	0	6
204	R:R:F302	R:R:M306	12.44	No	No	0	5	6
205	R:R:N303	R:R:N307	6.81	No	No	0	9	9
206	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
207	R:R:M318	R:R:S312	6.13	Yes	No	0	8	7
208	R:R:R314	R:R:Y313	18.52	Yes	No	5	7	5
209	R:R:F322	R:R:M318	4.98	No	Yes	0	6	8
210	R:R:V208	R:R:V282	3.21	No	Yes	0	4	5
211	R:R:S119	R:R:T117	3.2	No	No	0	1	6
212	R:R:T236	R:R:V232	3.17	No	No	0	5	7
213	R:R:T236	R:R:T252	3.14	No	No	0	5	5
214	R:R:F296	R:R:Y292	3.09	No	No	0	5	3
215	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
216	R:R:I74	R:R:V70	3.07	No	No	0	7	9
217	R:R:I181	R:R:V177	3.07	No	No	0	5	4
218	R:R:I212	R:R:V208	3.07	No	No	0	4	4
219	R:R:L87	R:R:V164	2.98	No	Yes	0	8	7
220	R:R:L140	R:R:V220	2.98	Yes	No	0	7	5
221	R:R:L207	R:R:V282	2.98	No	Yes	0	6	5
222	R:R:L224	R:R:V220	2.98	No	No	0	6	5
223	R:R:L264	R:R:V222	2.98	No	No	0	7	4
224	R:R:L257	R:R:V261	2.98	No	No	0	7	5
225	R:R:N77	R:R:V76	2.96	No	No	0	6	5
226	R:R:L116	R:R:T120	2.95	Yes	No	0	6	4
227	R:R:I57	R:R:I61	2.94	Yes	No	0	4	4
228	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
229	R:R:I262	R:R:I310	2.94	No	No	0	6	8
230	R:R:A42	R:R:H40	2.93	No	No	0	4	2
231	R:R:I30	R:R:L116	2.85	No	Yes	0	6	6
232	R:R:L139	R:R:M221	2.83	Yes	Yes	0	8	9
233	R:R:L140	R:R:M221	2.83	Yes	Yes	0	7	9
234	R:R:L264	R:R:M221	2.83	No	Yes	0	7	9
235	R:R:L298	R:R:L55	2.77	No	No	0	6	4
236	R:R:A66	R:R:F62	2.77	No	No	0	8	4
237	R:R:A305	R:R:F62	2.77	No	No	0	7	4
238	R:R:D251	R:R:M254	2.77	No	No	0	5	5
239	R:R:A305	R:R:F302	2.77	No	No	0	7	5
240	R:R:L122	R:R:N187	2.75	No	No	0	5	6
241	R:R:E317	R:R:K316	2.7	No	No	0	7	5
242	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
243	R:R:R162	R:R:S160	2.64	No	No	0	5	8
244	R:R:A94	R:R:W172	2.59	No	Yes	0	8	9
245	R:R:F213	R:R:M174	2.49	No	No	0	5	4
246	R:R:F229	R:R:M253	2.49	No	Yes	0	6	7
247	R:R:K258	R:R:R314	2.48	No	Yes	0	7	7
248	R:R:F97	R:R:L127	2.44	No	No	0	7	5
249	R:R:F25	R:R:N27	2.42	No	No	0	7	8
250	R:R:F96	R:R:N67	2.42	No	Yes	0	7	9
251	R:R:M153	R:R:Y231	2.39	No	No	0	7	6
252	R:R:L41	R:R:Y34	2.34	No	Yes	0	2	6
253	R:R:N27	R:R:Y26	2.33	No	No	0	8	4
254	R:R:E317	R:R:F80	2.33	No	Yes	0	7	8
255	R:R:G274	R:R:P273	2.03	No	Yes	0	5	9
256	R:R:G110	R:R:T109	1.82	No	No	0	5	5
257	R:R:G179	R:R:T130	1.82	No	No	0	7	6
258	R:R:G54	R:R:I57	1.76	No	Yes	0	4	4
259	R:R:G265	R:R:I268	1.76	No	No	0	4	6
260	R:R:G56	R:R:M106	1.75	No	No	0	6	6
261	R:R:C195	R:R:S203	1.72	No	No	0	9	5
262	R:R:A31	R:R:S29	1.71	No	No	0	2	4
263	R:R:C283	R:R:V282	1.71	No	Yes	0	4	5
264	R:R:C287	R:R:V289	1.71	No	Yes	0	5	4
265	R:R:A73	R:R:T321	1.68	No	No	0	7	7
266	R:R:C24	R:R:I189	1.64	No	Yes	0	5	3
267	R:R:C270	R:R:I269	1.64	No	No	0	9	5
268	R:R:S49	R:R:V48	1.62	No	No	0	1	3
269	R:R:A92	R:R:M71	1.61	No	No	0	9	7
270	R:R:A143	R:R:M221	1.61	No	Yes	0	8	9
271	R:R:A266	R:R:M306	1.61	No	No	0	6	6
272	R:R:V150	R:R:V232	1.6	No	No	0	8	7
273	R:R:V164	R:R:V165	1.6	Yes	No	0	7	1
274	R:R:V216	R:R:V219	1.6	No	No	0	4	3
275	R:R:T173	R:R:V170	1.59	No	No	0	3	3
276	R:R:T272	R:R:V276	1.59	No	No	0	5	6
277	R:R:C283	R:R:L279	1.59	No	No	0	4	6
278	R:R:A211	R:R:L275	1.58	No	No	0	4	6
279	R:R:A211	R:R:L278	1.58	No	No	0	4	6
280	R:R:A211	R:R:L279	1.58	No	No	0	4	6
281	R:R:A42	R:R:N46	1.56	No	No	0	4	2
282	R:R:I189	R:R:V118	1.54	Yes	No	0	3	2
283	R:R:I212	R:R:V216	1.54	No	No	0	4	4
284	R:R:A291	R:R:D288	1.54	No	No	0	2	1
285	R:R:I57	R:R:T58	1.52	Yes	No	0	4	5
286	R:R:M174	R:R:V170	1.52	No	No	0	4	3
287	R:R:G230	R:R:R233	1.5	No	No	0	2	5
288	R:R:N197	R:R:S37	1.49	No	No	0	5	7
289	R:R:L87	R:R:V167	1.49	No	No	0	8	6
290	R:R:L290	R:R:V289	1.49	No	Yes	0	3	4
291	R:R:E44	R:R:T43	1.41	No	No	0	1	3
292	R:R:E145	R:R:T149	1.41	No	No	0	8	8
293	R:R:L65	R:R:L69	1.38	No	No	0	4	7
294	R:R:F295	R:R:V48	1.31	No	No	0	4	3
295	R:R:R162	R:R:V166	1.31	No	No	0	5	3
296	R:R:D191	R:R:E193	1.3	No	No	0	4	4
297	R:R:I148	R:R:R163	1.25	No	No	0	5	6
298	R:R:Q234	R:R:R235	1.17	No	No	0	4	7
299	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
300	R:R:K50	R:R:W45	1.16	No	No	0	3	1
301	R:R:N112	R:R:W45	1.13	No	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	5.10167	6	1	6
2	R:R:I57	3.125	4	0	4
3	R:R:I63	4.1	5	0	8
4	R:R:N67	5.192	5	0	9
5	R:R:F80	9.42333	6	3	8
6	R:R:L91	5.128	5	2	9
7	R:R:D95	6.084	5	0	9
8	R:R:Y102	10.956	5	0	7
9	R:R:L116	3.52	4	1	6
10	R:R:W121	8.43	5	1	9
11	R:R:R124	6.90286	7	1	6
12	R:R:Q125	10.015	4	1	4
13	R:R:D129	6.7675	4	1	5
14	R:R:V136	5.5725	4	1	8
15	R:R:L139	5.0325	4	2	8
16	R:R:L140	4.7125	4	0	7
17	R:R:H147	8.6275	4	4	7
18	R:R:F151	11.9975	4	4	6
19	R:R:V164	3.7325	4	0	7
20	R:R:W172	4.5675	4	0	9
21	R:R:M178	4.145	4	1	5
22	R:R:I189	3.99	4	0	3
23	R:R:Y202	8.05167	6	1	4
24	R:R:Y206	8.9	5	1	7
25	R:R:W210	5.14	5	1	6
26	R:R:N214	9.2925	4	1	7
27	R:R:M221	2.525	4	0	9
28	R:R:M253	3.985	4	0	7
29	R:R:F267	10.08	4	1	9
30	R:R:W271	7.37375	8	1	8
31	R:R:P273	4.37	4	0	9
32	R:R:D281	7.665	4	0	4
33	R:R:V282	4.165	4	0	5
34	R:R:V289	3.0125	4	0	4
35	R:R:Y311	5.19571	7	2	9
36	R:R:R314	10.1375	4	5	7
37	R:R:M318	6.7175	4	0	8
38	L:L:?1	8.32385	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I189	R:R:L201	15.9428	4.28	Yes	No	0	3	1
2	R:R:F33	R:R:L201	28.967	20.7	No	No	0	6	1
3	R:R:F33	R:R:I192	26.3831	3.77	No	No	0	6	1
4	R:R:I192	R:R:R36	18.5716	6.26	No	No	0	1	3
5	R:R:F32	R:R:R36	15.9478	7.48	No	No	0	2	3
6	R:R:E28	R:R:F32	13.314	33.81	No	No	0	4	2
7	R:R:E28	R:R:F25	10.6702	3.5	No	No	0	4	7
8	R:R:L201	R:R:W121	46.4791	10.25	No	Yes	0	1	9
9	R:R:R124	R:R:W121	23.2995	8	Yes	Yes	1	6	9
10	L:L:?1	R:R:R124	36.7485	7.72	Yes	Yes	1	0	6
11	R:R:Q125	R:R:W121	24.1991	16.43	Yes	Yes	1	4	9
12	L:L:?1	R:R:Q125	22.4249	7.52	Yes	Yes	1	0	4
13	L:L:?1	R:R:E293	25.4585	23.38	Yes	No	0	0	4
14	R:R:E293	R:R:M198	24.0442	14.89	No	No	0	4	3
15	R:R:D281	R:R:M198	15.3131	11.09	Yes	No	0	4	3
16	R:R:L41	R:R:Y34	15.9728	2.34	No	Yes	0	2	6
17	R:R:L41	R:R:T43	12.8542	4.42	No	No	0	2	3
18	R:R:E44	R:R:T43	11.2799	1.41	No	No	0	1	3
19	L:L:?1	R:R:T109	11.065	5.2	Yes	No	1	0	5
20	L:L:?1	R:R:L297	10.8301	16.61	Yes	No	0	0	6
21	R:R:C60	R:R:Y102	12.8242	5.38	No	Yes	0	6	7
22	R:R:C60	R:R:F103	11.2349	6.98	No	No	0	6	6
23	R:R:I63	R:R:S304	12.9292	4.64	Yes	No	0	8	9
24	L:L:?1	R:R:W210	91.6987	8.04	Yes	Yes	1	0	6
25	R:R:W210	R:R:W271	100	4.69	Yes	Yes	1	6	8
26	R:R:N303	R:R:W271	85.4465	7.91	No	Yes	0	9	8
27	R:R:N303	R:R:N307	84.6969	6.81	No	No	0	9	9
28	R:R:D95	R:R:N307	74.4965	8.08	Yes	No	0	9	9
29	R:R:D95	R:R:N67	74.3365	8.08	Yes	Yes	0	9	9
30	R:R:A305	R:R:I63	14.7783	3.25	No	Yes	0	7	8
31	R:R:A92	R:R:N67	55.7599	4.69	No	Yes	0	9	9
32	R:R:A92	R:R:V70	52.7613	3.39	No	No	0	9	9
33	R:R:M318	R:R:V70	48.1733	4.56	Yes	No	0	8	9
34	R:R:F80	R:R:M318	43.7003	11.2	Yes	Yes	0	8	8
35	R:R:F80	R:R:Y85	30.7861	19.6	Yes	No	0	8	9
36	R:R:I84	R:R:Y85	27.4626	3.63	No	No	0	8	9
37	R:R:E145	R:R:I84	25.7734	9.56	No	No	0	8	8
38	R:R:E145	R:R:L87	16.0378	6.63	No	No	0	8	8
39	R:R:L87	R:R:V164	12.5544	2.98	No	Yes	0	8	7
40	R:R:L139	R:R:N307	41.9361	8.24	Yes	No	0	8	9
41	R:R:L139	R:R:Y311	16.1177	3.52	Yes	Yes	2	8	9
42	R:R:D95	R:R:L91	38.5876	5.43	Yes	Yes	0	9	9
43	R:R:L91	R:R:N138	30.9911	6.87	Yes	No	0	9	8
44	R:R:L139	R:R:L91	32.6703	5.54	Yes	Yes	2	8	9
45	R:R:N138	R:R:N90	22.3349	12.26	No	No	0	8	9
46	R:R:N90	R:R:W172	17.9469	6.78	No	Yes	0	9	9
47	R:R:F97	R:R:W172	11.2899	5.01	No	Yes	0	7	9
48	R:R:E301	R:R:Y102	12.4244	25.81	No	Yes	0	7	7
49	R:R:E301	R:R:L132	13.349	6.63	No	No	0	7	7
50	R:R:M178	R:R:W210	11.2849	3.49	Yes	Yes	1	5	6
51	R:R:V136	R:R:W271	36.3636	4.9	Yes	Yes	1	8	8
52	R:R:T217	R:R:V136	39.8421	4.76	No	Yes	0	7	8
53	R:R:F267	R:R:W271	10.2104	16.04	Yes	Yes	1	9	8
54	R:R:L140	R:R:T217	39.1674	5.9	Yes	No	0	7	7
55	R:R:F151	R:R:H147	33.29	15.84	Yes	Yes	4	6	7
56	R:R:H147	R:R:L224	62.9467	5.14	Yes	No	0	7	6
57	R:R:L224	R:R:V220	64.536	2.98	No	No	0	6	5
58	R:R:L140	R:R:V220	66.1152	2.98	Yes	No	0	7	5
59	R:R:H147	R:R:I228	26.3082	3.98	Yes	No	0	7	9
60	R:R:F151	R:R:V150	24.9288	3.93	Yes	No	0	6	8
61	R:R:I228	R:R:V150	24.7239	7.68	No	No	0	9	8
62	R:R:L207	R:R:V282	10.4003	2.98	No	Yes	0	6	5
63	L:L:?1	R:R:L207	11.7247	3.91	Yes	No	1	0	6
64	R:R:F218	R:R:F267	12.1046	11.79	No	Yes	0	5	9
65	R:R:F218	R:R:I268	13.7288	3.77	No	No	0	5	6
66	R:R:F229	R:R:L256	32.5454	7.31	No	No	0	6	7
67	R:R:L256	R:R:V232	35.8489	4.47	No	No	0	7	7
68	R:R:V150	R:R:V232	46.0843	1.6	No	No	0	8	7
69	R:R:F229	R:R:M253	21.7752	2.49	No	Yes	0	6	7
70	R:R:I310	R:R:Y311	10.1904	3.63	No	Yes	0	8	9
71	R:R:I268	R:R:T272	10.6802	6.08	No	No	0	6	5
72	R:R:D281	R:R:V289	10.3104	4.38	Yes	Yes	0	4	4
73	R:R:L140	R:R:M221	41.5663	2.83	Yes	Yes	0	7	9
74	R:R:L139	R:R:M221	43.4754	2.83	Yes	Yes	0	8	9
75	R:R:I63	R:R:N67	13.0291	4.25	Yes	Yes	0	8	9
76	R:R:D95	R:R:S304	15.478	5.89	Yes	No	0	9	9
77	L:L:?1	R:R:Y34	18.9465	3.31	Yes	Yes	1	0	6
78	R:R:L132	R:R:W271	13.239	6.83	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K39	R:R:Y34	10.75	1	No	Yes	8	6	1	1
R:R:T113	R:R:Y34	7.49	0	No	Yes	5	6	2	1
R:R:P200	R:R:Y34	5.56	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	3.31	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	8.96	1	Yes	No	0	8	0	1
R:R:K294	R:R:V52	13.66	1	No	No	4	5	1	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	8.44	0	No	Yes	5	6	2	1
R:R:K294	R:R:T109	4.5	1	No	No	4	5	1	1
L:L:?1	R:R:T109	5.2	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	2
R:R:L116	R:R:W121	3.42	1	Yes	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	Yes	Yes	6	6	2	1
R:R:R124	R:R:W121	8	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	16.43	1	Yes	Yes	4	9	1	2
R:R:P200	R:R:W121	4.05	0	No	Yes	6	9	2	2
R:R:Q125	R:R:R124	9.35	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	6.76	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	9.2	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	8.05	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:W210	3.42	1	No	Yes	7	6	2	1
R:R:L132	R:R:W271	6.83	1	No	Yes	7	8	2	2
R:R:M178	R:R:T133	4.52	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	11.13	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	18.08	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	0	No	No	4	3	1	2
R:R:A199	R:R:Y202	5.34	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	10.92	1	Yes	Yes	4	7	1	2
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
R:R:L207	R:R:L278	4.15	1	No	No	6	6	1	1
L:L:?1	R:R:L207	3.91	1	Yes	No	0	6	0	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	8.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	6.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	23.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	16.61	1	Yes	No	0	6	0	1
R:R:L207	R:R:V282	2.98	1	No	Yes	6	5	1	2
R:R:L41	R:R:Y34	2.34	0	No	Yes	2	6	2	1
R:R:G110	R:R:T109	1.82	0	No	No	5	5	2	1
R:R:A211	R:R:L278	1.58	0	No	No	4	6	2	1
R:R:N35	R:R:Y34	1.16	0	No	Yes	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	270
Number of Links	301
Number of Hubs	38
Number of Links mediated by Hubs	150
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	52202
Length Of Smallest Path	3
Average Path Length	12.8434
Length of Longest Path	29
Minimum Path Strength	1.145
Average Path Strength	6.63292
Maximum Path Strength	20.645
Minimum Path Correlation	0.7
Average Path Correlation	0.929172
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.6745
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2191
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU5_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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