psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F25	R:R:Q23	19.91	No	No	0	7	3
2	R:R:C190	R:R:C24	7.28	No	No	0	3	5
3	R:R:E28	R:R:F25	3.5	No	No	0	4	7
4	R:R:E28	R:R:F32	33.81	No	No	0	4	2
5	R:R:F32	R:R:R36	7.48	No	No	0	2	3
6	R:R:F33	R:R:I192	3.77	No	No	0	6	1
7	R:R:F33	R:R:L201	20.7	No	No	0	6	1
8	R:R:K39	R:R:Y34	10.75	No	Yes	1	8	6
9	R:R:T113	R:R:Y34	7.49	No	Yes	0	5	6
10	R:R:P200	R:R:Y34	5.56	No	Yes	0	6	6
11	L:L:?1	R:R:Y34	3.31	Yes	Yes	1	0	6
12	R:R:I192	R:R:R36	6.26	No	No	0	1	3
13	R:R:G38	R:R:S37	3.71	No	No	0	4	7
14	L:L:?1	R:R:K39	8.96	Yes	No	1	0	8
15	R:R:L41	R:R:T43	4.42	No	No	0	2	3
16	R:R:L41	R:R:R114	4.86	No	No	0	2	6
17	R:R:E44	R:R:N46	3.94	No	No	0	1	2
18	R:R:P111	R:R:W45	17.57	No	No	0	4	1
19	R:R:N46	R:R:S49	8.94	No	No	0	2	1
20	R:R:K294	R:R:V52	13.66	No	No	0	4	5
21	R:R:G54	R:R:M53	3.49	No	No	0	4	4
22	R:R:F103	R:R:I57	6.28	No	Yes	0	6	4
23	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
24	R:R:C60	R:R:F103	6.98	No	No	0	6	6
25	R:R:I63	R:R:N67	4.25	Yes	Yes	0	8	9
26	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
27	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
28	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
29	R:R:F96	R:R:M64	11.2	No	No	0	7	6
30	R:R:L100	R:R:M64	5.65	No	No	0	4	6
31	R:R:A66	R:R:P308	3.74	No	No	0	8	9
32	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
33	R:R:D95	R:R:N67	8.08	Yes	Yes	0	9	9
34	R:R:N67	R:R:P308	6.52	Yes	No	0	9	9
35	R:R:F96	R:R:L68	4.87	No	No	0	7	4
36	R:R:A92	R:R:V70	3.39	No	No	0	9	9
37	R:R:M318	R:R:V70	4.56	Yes	No	0	8	9
38	R:R:A89	R:R:I74	6.5	No	No	0	7	7
39	R:R:F80	R:R:N77	9.67	Yes	No	3	8	6
40	R:R:N77	R:R:T321	7.31	No	No	3	6	7
41	R:R:F80	R:R:R79	8.55	Yes	No	0	8	6
42	R:R:F80	R:R:Y85	19.6	Yes	No	0	8	9
43	R:R:F80	R:R:M318	11.2	Yes	Yes	0	8	8
44	R:R:F80	R:R:T321	5.19	Yes	No	3	8	7
45	R:R:H81	R:R:Y86	19.6	No	No	0	8	4
46	R:R:F82	R:R:P83	4.33	No	No	0	7	6
47	R:R:P83	R:R:V164	5.3	No	Yes	0	6	7
48	R:R:I84	R:R:Y85	3.63	No	No	0	8	9
49	R:R:E145	R:R:I84	9.56	No	No	0	8	8
50	R:R:D315	R:R:Y85	5.75	No	No	0	8	9
51	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
52	R:R:V164	R:R:Y86	5.05	Yes	No	0	7	4
53	R:R:E145	R:R:L87	6.63	No	No	0	8	8
54	R:R:M88	R:R:Y311	7.18	No	Yes	0	8	9
55	R:R:N138	R:R:N90	12.26	No	No	0	8	9
56	R:R:I168	R:R:N90	12.74	No	No	0	8	9
57	R:R:N90	R:R:W172	6.78	No	Yes	0	9	9
58	R:R:D95	R:R:L91	5.43	Yes	Yes	0	9	9
59	R:R:L91	R:R:N138	6.87	Yes	No	0	9	8
60	R:R:L139	R:R:L91	5.54	Yes	Yes	2	8	9
61	R:R:I142	R:R:L91	4.28	No	Yes	2	8	9
62	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
63	R:R:D95	R:R:S304	5.89	Yes	No	0	9	9
64	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
65	R:R:F97	R:R:T130	3.89	No	No	0	7	6
66	R:R:F97	R:R:W172	5.01	No	Yes	0	7	9
67	R:R:A98	R:R:S131	3.42	No	No	0	8	6
68	R:R:A98	R:R:S304	3.42	No	No	0	8	9
69	R:R:A101	R:R:I128	3.25	No	No	0	5	6
70	R:R:A101	R:R:S131	3.42	No	No	0	5	6
71	R:R:M106	R:R:Y102	7.18	No	Yes	0	6	7
72	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
73	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
74	R:R:E301	R:R:Y102	25.81	No	Yes	0	7	7
75	R:R:F103	R:R:F107	5.36	No	No	0	6	5
76	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
77	R:R:L123	R:R:Y104	3.52	No	No	0	4	5
78	R:R:L105	R:R:R124	6.07	No	Yes	0	6	6
79	R:R:I128	R:R:L105	4.28	No	No	0	6	6
80	R:R:N108	R:R:R124	8.44	No	Yes	0	5	6
81	R:R:K294	R:R:T109	4.5	No	No	1	4	5
82	L:L:?1	R:R:T109	5.2	Yes	No	1	0	5
83	R:R:G110	R:R:P111	4.06	No	No	0	5	4
84	R:R:N112	R:R:R115	12.05	No	No	0	4	3
85	R:R:R124	R:R:T113	3.88	Yes	No	0	6	5
86	R:R:L116	R:R:W121	3.42	Yes	Yes	1	6	9
87	R:R:L116	R:R:R124	4.86	Yes	Yes	1	6	6
88	R:R:T117	R:R:T120	4.71	No	No	0	6	4
89	R:R:R124	R:R:W121	8	Yes	Yes	1	6	9
90	R:R:Q125	R:R:W121	16.43	Yes	Yes	1	4	9
91	R:R:P200	R:R:W121	4.05	No	Yes	0	6	9
92	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
93	R:R:Q125	R:R:R124	9.35	Yes	Yes	1	4	6
94	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
95	R:R:Q125	R:R:Y202	6.76	Yes	Yes	1	4	4
96	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
97	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
98	R:R:D129	R:R:Y202	9.2	Yes	Yes	1	5	4
99	R:R:D129	R:R:Y206	8.05	Yes	Yes	1	5	7
100	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
101	R:R:I176	R:R:T130	4.56	No	No	0	3	6
102	R:R:L132	R:R:W210	3.42	No	Yes	1	7	6
103	R:R:L132	R:R:W271	6.83	No	Yes	1	7	8
104	R:R:E301	R:R:L132	6.63	No	No	0	7	7
105	R:R:A175	R:R:T133	3.36	No	No	0	8	6
106	R:R:M178	R:R:T133	4.52	Yes	No	1	5	6
107	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
108	R:R:A134	R:R:W172	3.89	No	Yes	0	7	9
109	R:R:N214	R:R:V136	7.39	Yes	Yes	1	7	8
110	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
111	R:R:F267	R:R:V136	5.24	Yes	Yes	1	9	8
112	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
113	R:R:A137	R:R:I171	4.87	No	No	0	5	7
114	R:R:I171	R:R:N138	9.91	No	No	0	7	8
115	R:R:L139	R:R:N307	8.24	Yes	No	0	8	9
116	R:R:L139	R:R:Y311	3.52	Yes	Yes	2	8	9
117	R:R:I144	R:R:L140	7.14	No	Yes	0	6	7
118	R:R:L140	R:R:T217	5.9	Yes	No	0	7	7
119	R:R:A141	R:R:I171	3.25	No	No	0	8	7
120	R:R:I142	R:R:R146	3.76	No	No	2	8	9
121	R:R:I142	R:R:Y311	6.04	No	Yes	2	8	9
122	R:R:R146	R:R:Y225	9.26	No	No	0	9	9
123	R:R:R146	R:R:Y311	6.17	No	Yes	2	9	9
124	R:R:F151	R:R:H147	15.84	Yes	Yes	4	6	7
125	R:R:H147	R:R:L224	5.14	Yes	No	0	7	6
126	R:R:H147	R:R:H227	9.55	Yes	No	4	7	5
127	R:R:H147	R:R:I228	3.98	Yes	No	0	7	9
128	R:R:R152	R:R:T149	5.17	No	No	0	5	8
129	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
130	R:R:I228	R:R:V150	7.68	No	No	0	9	8
131	R:R:F151	R:R:H227	15.84	Yes	No	4	6	5
132	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
133	R:R:R152	R:R:T157	11.64	No	No	0	5	4
134	R:R:M159	R:R:R152	3.72	No	No	0	6	5
135	R:R:Q154	R:R:T157	9.92	No	No	0	4	4
136	R:R:H156	R:R:L155	9	No	No	0	4	8
137	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
138	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
139	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
140	R:R:I181	R:R:P182	3.39	No	No	0	5	6
141	R:R:P182	R:R:Y202	11.13	No	Yes	1	6	4
142	R:R:P182	R:R:Y206	18.08	No	Yes	1	6	7
143	R:R:G185	R:R:V184	3.68	No	No	0	5	5
144	R:R:S205	R:R:W186	8.65	No	No	0	5	6
145	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
146	R:R:I189	R:R:N187	8.5	Yes	No	0	3	6
147	R:R:C188	R:R:C195	7.28	No	No	0	5	9
148	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
149	R:R:E193	R:R:I192	4.1	No	No	0	4	1
150	R:R:A199	R:R:S196	3.42	No	No	0	4	5
151	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
152	R:R:D281	R:R:N197	10.77	Yes	No	0	4	5
153	R:R:L277	R:R:M198	7.07	No	No	0	4	3
154	R:R:D281	R:R:M198	11.09	Yes	No	0	4	3
155	R:R:E293	R:R:M198	14.89	No	No	0	4	3
156	R:R:A199	R:R:Y202	5.34	No	Yes	0	4	4
157	R:R:Y202	R:R:Y206	10.92	Yes	Yes	1	4	7
158	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
159	R:R:S203	R:R:S205	4.89	No	No	0	5	5
160	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
161	R:R:L207	R:R:L278	4.15	No	No	1	6	6
162	L:L:?1	R:R:L207	3.91	Yes	No	1	0	6
163	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
164	L:L:?1	R:R:W210	8.04	Yes	Yes	1	0	6
165	R:R:F213	R:R:T217	5.19	No	No	0	5	7
166	R:R:F267	R:R:N214	7.25	Yes	Yes	1	9	7
167	R:R:N214	R:R:W271	10.17	Yes	Yes	1	7	8
168	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
169	R:R:F218	R:R:V222	7.87	No	No	0	5	4
170	R:R:F218	R:R:F267	11.79	No	Yes	0	5	9
171	R:R:F218	R:R:I268	3.77	No	No	0	5	6
172	R:R:V260	R:R:Y225	5.05	No	No	0	8	9
173	R:R:V263	R:R:Y225	5.05	No	No	0	8	9
174	R:R:F229	R:R:L256	7.31	No	No	0	6	7
175	R:R:F229	R:R:L257	7.31	No	No	0	6	7
176	R:R:R235	R:R:Y231	14.4	No	No	0	7	6
177	R:R:L256	R:R:V232	4.47	No	No	0	7	7
178	R:R:M253	R:R:R233	4.96	Yes	No	0	7	5
179	R:R:M237	R:R:M253	4.33	No	Yes	0	5	7
180	R:R:D251	R:R:M253	4.16	No	Yes	0	5	7
181	R:R:R314	R:R:S255	7.91	Yes	No	0	7	7
182	R:R:T259	R:R:Y313	4.99	No	No	5	8	5
183	R:R:R314	R:R:T259	11.64	Yes	No	5	7	8
184	R:R:I262	R:R:Y313	7.25	No	No	0	6	5
185	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
186	R:R:F267	R:R:W271	16.04	Yes	Yes	1	9	8
187	R:R:I268	R:R:T272	6.08	No	No	0	6	5
188	R:R:C270	R:R:N303	9.45	No	No	0	9	9
189	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
190	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
191	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
192	R:R:P273	R:R:T272	3.5	Yes	No	0	9	5
193	R:R:F296	R:R:P273	8.67	No	Yes	0	5	9
194	R:R:L299	R:R:P273	3.28	No	Yes	0	7	9
195	R:R:F296	R:R:L277	8.53	No	No	0	5	4
196	L:L:?1	R:R:L278	6.84	Yes	No	1	0	6
197	R:R:L280	R:R:V289	4.47	No	Yes	0	5	4
198	R:R:D281	R:R:V289	4.38	Yes	Yes	0	4	4
199	R:R:C284	R:R:P285	3.77	No	No	0	4	3
200	R:R:C284	R:R:C287	7.28	No	No	0	4	5
201	L:L:?1	R:R:E293	23.38	Yes	No	0	0	4
202	L:L:?1	R:R:K294	6.97	Yes	No	1	0	4
203	L:L:?1	R:R:L297	16.61	Yes	No	0	0	6
204	R:R:F302	R:R:M306	12.44	No	No	0	5	6
205	R:R:N303	R:R:N307	6.81	No	No	0	9	9
206	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
207	R:R:M318	R:R:S312	6.13	Yes	No	0	8	7
208	R:R:R314	R:R:Y313	18.52	Yes	No	5	7	5
209	R:R:F322	R:R:M318	4.98	No	Yes	0	6	8
210	R:R:V208	R:R:V282	3.21	No	Yes	0	4	5
211	R:R:S119	R:R:T117	3.2	No	No	0	1	6
212	R:R:T236	R:R:V232	3.17	No	No	0	5	7
213	R:R:T236	R:R:T252	3.14	No	No	0	5	5
214	R:R:F296	R:R:Y292	3.09	No	No	0	5	3
215	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
216	R:R:I74	R:R:V70	3.07	No	No	0	7	9
217	R:R:I181	R:R:V177	3.07	No	No	0	5	4
218	R:R:I212	R:R:V208	3.07	No	No	0	4	4
219	R:R:L87	R:R:V164	2.98	No	Yes	0	8	7
220	R:R:L140	R:R:V220	2.98	Yes	No	0	7	5
221	R:R:L207	R:R:V282	2.98	No	Yes	0	6	5
222	R:R:L224	R:R:V220	2.98	No	No	0	6	5
223	R:R:L264	R:R:V222	2.98	No	No	0	7	4
224	R:R:L257	R:R:V261	2.98	No	No	0	7	5
225	R:R:N77	R:R:V76	2.96	No	No	0	6	5
226	R:R:L116	R:R:T120	2.95	Yes	No	0	6	4
227	R:R:I57	R:R:I61	2.94	Yes	No	0	4	4
228	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
229	R:R:I262	R:R:I310	2.94	No	No	0	6	8
230	R:R:A42	R:R:H40	2.93	No	No	0	4	2
231	R:R:I30	R:R:L116	2.85	No	Yes	0	6	6
232	R:R:L139	R:R:M221	2.83	Yes	Yes	0	8	9
233	R:R:L140	R:R:M221	2.83	Yes	Yes	0	7	9
234	R:R:L264	R:R:M221	2.83	No	Yes	0	7	9
235	R:R:L298	R:R:L55	2.77	No	No	0	6	4
236	R:R:A66	R:R:F62	2.77	No	No	0	8	4
237	R:R:A305	R:R:F62	2.77	No	No	0	7	4
238	R:R:D251	R:R:M254	2.77	No	No	0	5	5
239	R:R:A305	R:R:F302	2.77	No	No	0	7	5
240	R:R:L122	R:R:N187	2.75	No	No	0	5	6
241	R:R:E317	R:R:K316	2.7	No	No	0	7	5
242	R:R:A291	R:R:Y292	2.67	No	No	0	2	3
243	R:R:R162	R:R:S160	2.64	No	No	0	5	8
244	R:R:A94	R:R:W172	2.59	No	Yes	0	8	9
245	R:R:F213	R:R:M174	2.49	No	No	0	5	4
246	R:R:F229	R:R:M253	2.49	No	Yes	0	6	7
247	R:R:K258	R:R:R314	2.48	No	Yes	0	7	7
248	R:R:F97	R:R:L127	2.44	No	No	0	7	5
249	R:R:F25	R:R:N27	2.42	No	No	0	7	8
250	R:R:F96	R:R:N67	2.42	No	Yes	0	7	9
251	R:R:M153	R:R:Y231	2.39	No	No	0	7	6
252	R:R:L41	R:R:Y34	2.34	No	Yes	0	2	6
253	R:R:N27	R:R:Y26	2.33	No	No	0	8	4
254	R:R:E317	R:R:F80	2.33	No	Yes	0	7	8
255	R:R:G274	R:R:P273	2.03	No	Yes	0	5	9
256	R:R:G110	R:R:T109	1.82	No	No	0	5	5
257	R:R:G179	R:R:T130	1.82	No	No	0	7	6
258	R:R:G54	R:R:I57	1.76	No	Yes	0	4	4
259	R:R:G265	R:R:I268	1.76	No	No	0	4	6
260	R:R:G56	R:R:M106	1.75	No	No	0	6	6
261	R:R:C195	R:R:S203	1.72	No	No	0	9	5
262	R:R:A31	R:R:S29	1.71	No	No	0	2	4
263	R:R:C283	R:R:V282	1.71	No	Yes	0	4	5
264	R:R:C287	R:R:V289	1.71	No	Yes	0	5	4
265	R:R:A73	R:R:T321	1.68	No	No	0	7	7
266	R:R:C24	R:R:I189	1.64	No	Yes	0	5	3
267	R:R:C270	R:R:I269	1.64	No	No	0	9	5
268	R:R:S49	R:R:V48	1.62	No	No	0	1	3
269	R:R:A92	R:R:M71	1.61	No	No	0	9	7
270	R:R:A143	R:R:M221	1.61	No	Yes	0	8	9
271	R:R:A266	R:R:M306	1.61	No	No	0	6	6
272	R:R:V150	R:R:V232	1.6	No	No	0	8	7
273	R:R:V164	R:R:V165	1.6	Yes	No	0	7	1
274	R:R:V216	R:R:V219	1.6	No	No	0	4	3
275	R:R:T173	R:R:V170	1.59	No	No	0	3	3
276	R:R:T272	R:R:V276	1.59	No	No	0	5	6
277	R:R:C283	R:R:L279	1.59	No	No	0	4	6
278	R:R:A211	R:R:L275	1.58	No	No	0	4	6
279	R:R:A211	R:R:L278	1.58	No	No	0	4	6
280	R:R:A211	R:R:L279	1.58	No	No	0	4	6
281	R:R:A42	R:R:N46	1.56	No	No	0	4	2
282	R:R:I189	R:R:V118	1.54	Yes	No	0	3	2
283	R:R:I212	R:R:V216	1.54	No	No	0	4	4
284	R:R:A291	R:R:D288	1.54	No	No	0	2	1
285	R:R:I57	R:R:T58	1.52	Yes	No	0	4	5
286	R:R:M174	R:R:V170	1.52	No	No	0	4	3
287	R:R:G230	R:R:R233	1.5	No	No	0	2	5
288	R:R:N197	R:R:S37	1.49	No	No	0	5	7
289	R:R:L87	R:R:V167	1.49	No	No	0	8	6
290	R:R:L290	R:R:V289	1.49	No	Yes	0	3	4
291	R:R:E44	R:R:T43	1.41	No	No	0	1	3
292	R:R:E145	R:R:T149	1.41	No	No	0	8	8
293	R:R:L65	R:R:L69	1.38	No	No	0	4	7
294	R:R:F295	R:R:V48	1.31	No	No	0	4	3
295	R:R:R162	R:R:V166	1.31	No	No	0	5	3
296	R:R:D191	R:R:E193	1.3	No	No	0	4	4
297	R:R:I148	R:R:R163	1.25	No	No	0	5	6
298	R:R:Q234	R:R:R235	1.17	No	No	0	4	7
299	R:R:N35	R:R:Y34	1.16	No	Yes	0	7	6
300	R:R:K50	R:R:W45	1.16	No	No	0	3	1
301	R:R:N112	R:R:W45	1.13	No	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	5.10167	6	1	6
2	R:R:I57	3.125	4	0	4
3	R:R:I63	4.1	5	0	8
4	R:R:N67	5.192	5	0	9
5	R:R:F80	9.42333	6	3	8
6	R:R:L91	5.128	5	2	9
7	R:R:D95	6.084	5	0	9
8	R:R:Y102	10.956	5	0	7
9	R:R:L116	3.52	4	1	6
10	R:R:W121	8.43	5	1	9
11	R:R:R124	6.90286	7	1	6
12	R:R:Q125	10.015	4	1	4
13	R:R:D129	6.7675	4	1	5
14	R:R:V136	5.5725	4	1	8
15	R:R:L139	5.0325	4	2	8
16	R:R:L140	4.7125	4	0	7
17	R:R:H147	8.6275	4	4	7
18	R:R:F151	11.9975	4	4	6
19	R:R:V164	3.7325	4	0	7
20	R:R:W172	4.5675	4	0	9
21	R:R:M178	4.145	4	1	5
22	R:R:I189	3.99	4	0	3
23	R:R:Y202	8.05167	6	1	4
24	R:R:Y206	8.9	5	1	7
25	R:R:W210	5.14	5	1	6
26	R:R:N214	9.2925	4	1	7
27	R:R:M221	2.525	4	0	9
28	R:R:M253	3.985	4	0	7
29	R:R:F267	10.08	4	1	9
30	R:R:W271	7.37375	8	1	8
31	R:R:P273	4.37	4	0	9
32	R:R:D281	7.665	4	0	4
33	R:R:V282	4.165	4	0	5
34	R:R:V289	3.0125	4	0	4
35	R:R:Y311	5.19571	7	2	9
36	R:R:R314	10.1375	4	5	7
37	R:R:M318	6.7175	4	0	8
38	L:L:?1	8.32385	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I189	R:R:L201	15.9428	4.28	Yes	No	0	3	1
2	R:R:F33	R:R:L201	28.967	20.7	No	No	0	6	1
3	R:R:F33	R:R:I192	26.3831	3.77	No	No	0	6	1
4	R:R:I192	R:R:R36	18.5716	6.26	No	No	0	1	3
5	R:R:F32	R:R:R36	15.9478	7.48	No	No	0	2	3
6	R:R:E28	R:R:F32	13.314	33.81	No	No	0	4	2
7	R:R:E28	R:R:F25	10.6702	3.5	No	No	0	4	7
8	R:R:L201	R:R:W121	46.4791	10.25	No	Yes	0	1	9
9	R:R:R124	R:R:W121	23.2995	8	Yes	Yes	1	6	9
10	L:L:?1	R:R:R124	36.7485	7.72	Yes	Yes	1	0	6
11	R:R:Q125	R:R:W121	24.1991	16.43	Yes	Yes	1	4	9
12	L:L:?1	R:R:Q125	22.4249	7.52	Yes	Yes	1	0	4
13	L:L:?1	R:R:E293	25.4585	23.38	Yes	No	0	0	4
14	R:R:E293	R:R:M198	24.0442	14.89	No	No	0	4	3
15	R:R:D281	R:R:M198	15.3131	11.09	Yes	No	0	4	3
16	R:R:L41	R:R:Y34	15.9728	2.34	No	Yes	0	2	6
17	R:R:L41	R:R:T43	12.8542	4.42	No	No	0	2	3
18	R:R:E44	R:R:T43	11.2799	1.41	No	No	0	1	3
19	L:L:?1	R:R:T109	11.065	5.2	Yes	No	1	0	5
20	L:L:?1	R:R:L297	10.8301	16.61	Yes	No	0	0	6
21	R:R:C60	R:R:Y102	12.8242	5.38	No	Yes	0	6	7
22	R:R:C60	R:R:F103	11.2349	6.98	No	No	0	6	6
23	R:R:I63	R:R:S304	12.9292	4.64	Yes	No	0	8	9
24	L:L:?1	R:R:W210	91.6987	8.04	Yes	Yes	1	0	6
25	R:R:W210	R:R:W271	100	4.69	Yes	Yes	1	6	8
26	R:R:N303	R:R:W271	85.4465	7.91	No	Yes	0	9	8
27	R:R:N303	R:R:N307	84.6969	6.81	No	No	0	9	9
28	R:R:D95	R:R:N307	74.4965	8.08	Yes	No	0	9	9
29	R:R:D95	R:R:N67	74.3365	8.08	Yes	Yes	0	9	9
30	R:R:A305	R:R:I63	14.7783	3.25	No	Yes	0	7	8
31	R:R:A92	R:R:N67	55.7599	4.69	No	Yes	0	9	9
32	R:R:A92	R:R:V70	52.7613	3.39	No	No	0	9	9
33	R:R:M318	R:R:V70	48.1733	4.56	Yes	No	0	8	9
34	R:R:F80	R:R:M318	43.7003	11.2	Yes	Yes	0	8	8
35	R:R:F80	R:R:Y85	30.7861	19.6	Yes	No	0	8	9
36	R:R:I84	R:R:Y85	27.4626	3.63	No	No	0	8	9
37	R:R:E145	R:R:I84	25.7734	9.56	No	No	0	8	8
38	R:R:E145	R:R:L87	16.0378	6.63	No	No	0	8	8
39	R:R:L87	R:R:V164	12.5544	2.98	No	Yes	0	8	7
40	R:R:L139	R:R:N307	41.9361	8.24	Yes	No	0	8	9
41	R:R:L139	R:R:Y311	16.1177	3.52	Yes	Yes	2	8	9
42	R:R:D95	R:R:L91	38.5876	5.43	Yes	Yes	0	9	9
43	R:R:L91	R:R:N138	30.9911	6.87	Yes	No	0	9	8
44	R:R:L139	R:R:L91	32.6703	5.54	Yes	Yes	2	8	9
45	R:R:N138	R:R:N90	22.3349	12.26	No	No	0	8	9
46	R:R:N90	R:R:W172	17.9469	6.78	No	Yes	0	9	9
47	R:R:F97	R:R:W172	11.2899	5.01	No	Yes	0	7	9
48	R:R:E301	R:R:Y102	12.4244	25.81	No	Yes	0	7	7
49	R:R:E301	R:R:L132	13.349	6.63	No	No	0	7	7
50	R:R:M178	R:R:W210	11.2849	3.49	Yes	Yes	1	5	6
51	R:R:V136	R:R:W271	36.3636	4.9	Yes	Yes	1	8	8
52	R:R:T217	R:R:V136	39.8421	4.76	No	Yes	0	7	8
53	R:R:F267	R:R:W271	10.2104	16.04	Yes	Yes	1	9	8
54	R:R:L140	R:R:T217	39.1674	5.9	Yes	No	0	7	7
55	R:R:F151	R:R:H147	33.29	15.84	Yes	Yes	4	6	7
56	R:R:H147	R:R:L224	62.9467	5.14	Yes	No	0	7	6
57	R:R:L224	R:R:V220	64.536	2.98	No	No	0	6	5
58	R:R:L140	R:R:V220	66.1152	2.98	Yes	No	0	7	5
59	R:R:H147	R:R:I228	26.3082	3.98	Yes	No	0	7	9
60	R:R:F151	R:R:V150	24.9288	3.93	Yes	No	0	6	8
61	R:R:I228	R:R:V150	24.7239	7.68	No	No	0	9	8
62	R:R:L207	R:R:V282	10.4003	2.98	No	Yes	0	6	5
63	L:L:?1	R:R:L207	11.7247	3.91	Yes	No	1	0	6
64	R:R:F218	R:R:F267	12.1046	11.79	No	Yes	0	5	9
65	R:R:F218	R:R:I268	13.7288	3.77	No	No	0	5	6
66	R:R:F229	R:R:L256	32.5454	7.31	No	No	0	6	7
67	R:R:L256	R:R:V232	35.8489	4.47	No	No	0	7	7
68	R:R:V150	R:R:V232	46.0843	1.6	No	No	0	8	7
69	R:R:F229	R:R:M253	21.7752	2.49	No	Yes	0	6	7
70	R:R:I310	R:R:Y311	10.1904	3.63	No	Yes	0	8	9
71	R:R:I268	R:R:T272	10.6802	6.08	No	No	0	6	5
72	R:R:D281	R:R:V289	10.3104	4.38	Yes	Yes	0	4	4
73	R:R:L140	R:R:M221	41.5663	2.83	Yes	Yes	0	7	9
74	R:R:L139	R:R:M221	43.4754	2.83	Yes	Yes	0	8	9
75	R:R:I63	R:R:N67	13.0291	4.25	Yes	Yes	0	8	9
76	R:R:D95	R:R:S304	15.478	5.89	Yes	No	0	9	9
77	L:L:?1	R:R:Y34	18.9465	3.31	Yes	Yes	1	0	6
78	R:R:L132	R:R:W271	13.239	6.83	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K39	R:R:Y34	10.75	1	No	Yes	8	6	1	1
R:R:T113	R:R:Y34	7.49	0	No	Yes	5	6	2	1
R:R:P200	R:R:Y34	5.56	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	3.31	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	8.96	1	Yes	No	0	8	0	1
R:R:K294	R:R:V52	13.66	1	No	No	4	5	1	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	8.44	0	No	Yes	5	6	2	1
R:R:K294	R:R:T109	4.5	1	No	No	4	5	1	1
L:L:?1	R:R:T109	5.2	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	2
R:R:L116	R:R:W121	3.42	1	Yes	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	Yes	Yes	6	6	2	1
R:R:R124	R:R:W121	8	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	16.43	1	Yes	Yes	4	9	1	2
R:R:P200	R:R:W121	4.05	0	No	Yes	6	9	2	2
R:R:Q125	R:R:R124	9.35	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	6.76	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	9.2	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	8.05	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:W210	3.42	1	No	Yes	7	6	2	1
R:R:L132	R:R:W271	6.83	1	No	Yes	7	8	2	2
R:R:M178	R:R:T133	4.52	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	11.13	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	18.08	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	0	No	No	4	3	1	2
R:R:A199	R:R:Y202	5.34	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	10.92	1	Yes	Yes	4	7	1	2
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
R:R:L207	R:R:L278	4.15	1	No	No	6	6	1	1
L:L:?1	R:R:L207	3.91	1	Yes	No	0	6	0	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	8.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	6.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	23.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	16.61	1	Yes	No	0	6	0	1
R:R:L207	R:R:V282	2.98	1	No	Yes	6	5	1	2
R:R:L41	R:R:Y34	2.34	0	No	Yes	2	6	2	1
R:R:G110	R:R:T109	1.82	0	No	No	5	5	2	1
R:R:A211	R:R:L278	1.58	0	No	No	4	6	2	1
R:R:N35	R:R:Y34	1.16	0	No	Yes	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	270
Number of Links	301
Number of Hubs	38
Number of Links mediated by Hubs	150
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	52202
Length Of Smallest Path	3
Average Path Length	12.8434
Length of Longest Path	29
Minimum Path Strength	1.145
Average Path Strength	6.63292
Maximum Path Strength	20.645
Minimum Path Correlation	0.7
Average Path Correlation	0.929172
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.6745
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2191
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • binding • ion binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • small molecule binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • protein binding • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • glutamatergic synapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • dendritic shaft • plasma membrane bounded cell projection • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • heterocyclic compound binding • ribonucleotide binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • mitotic spindle organization • mitotic cell cycle process • microtubule-based process • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU5_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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