Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.900621610
2R:R:Y34 6.65667616
3R:R:K39 7.525418
4R:R:V70 3.4275409
5R:R:F80 8.12167628
6R:R:N90 11.6575419
7R:R:L91 6.186519
8R:R:D95 8.88519
9R:R:Y102 6.69667637
10R:R:M106 4.9125436
11R:R:W121 9.21571719
12R:R:R124 10.156516
13R:R:Q125 10.94414
14R:R:D129 8.758515
15R:R:L132 7.09407
16R:R:V136 6.6418
17R:R:N138 9.4275418
18R:R:L139 6.6775418
19R:R:E145 6.03508
20R:R:R146 6.346519
21R:R:H147 9.97447
22R:R:F151 11.9475446
23R:R:I171 5.918517
24R:R:M178 5.7825415
25R:R:L201 8.8525401
26R:R:Y202 6.03429714
27R:R:Y206 7.322517
28R:R:W210 8.65714716
29R:R:N214 7.536517
30R:R:T217 5.82407
31R:R:F218 6.825415
32R:R:Y225 6.145619
33R:R:F229 5.5875406
34R:R:F267 9.545419
35R:R:W271 8.74667618
36R:R:E293 9.0975414
37R:R:N303 7.26419
38R:R:S304 4.6925419
39R:R:M306 3.59406
40R:R:N307 10.57419
41R:R:Y311 5.42375819
42R:R:M318 6.545408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y34 25.07076.71YesYes106
2L:L:?1 R:R:R124 26.031211.3YesYes106
3R:R:R124 R:R:W121 16.541713YesYes169
4R:R:W121 R:R:Y34 16.15611.58YesYes196
5R:R:L201 R:R:W121 40.567413.67YesYes019
6R:R:F33 R:R:L201 39.230414.61NoYes061
7R:R:F32 R:R:F33 22.43517.5NoNo026
8L:L:?1 R:R:Q125 17.385418.1YesYes104
9R:R:Q125 R:R:W121 15.685713.14YesYes149
10R:R:F32 R:R:R36 11.2238.55NoNo023
11R:R:F33 R:R:I189 11.2236.28NoNo063
12L:L:?1 R:R:E293 19.88729.48YesYes104
13L:L:?1 R:R:T109 21.70527.38YesNo005
14R:R:G110 R:R:T109 20.57875.46NoNo055
15R:R:G110 R:R:P111 11.67174.06NoNo054
16L:L:?1 R:R:L132 60.66663.96YesYes007
17R:R:L132 R:R:S131 29.39674.5YesNo076
18R:R:A98 R:R:S131 28.13813.42NoNo086
19R:R:A98 R:R:S304 27.9893.42NoYes089
20R:R:D95 R:R:S304 27.89537.36YesYes199
21R:R:D95 R:R:N67 10012.12YesNo099
22R:R:L132 R:R:W271 44.27567.97YesYes078
23R:R:N303 R:R:W271 88.19469.04YesYes198
24R:R:N303 R:R:N307 79.576512.26YesYes199
25R:R:D95 R:R:N307 71.70069.42YesYes199
26L:L:?1 R:R:W210 61.682413.85YesYes106
27R:R:W210 R:R:W271 59.98435.62YesYes168
28R:R:A92 R:R:N67 96.17354.69NoNo099
29R:R:A92 R:R:V70 93.84073.39NoYes099
30R:R:S312 R:R:V70 44.41084.85NoYes079
31R:R:M318 R:R:S312 43.53954.6YesNo087
32R:R:F80 R:R:M318 46.493111.2YesYes088
33R:R:F322 R:R:V70 47.05863.93NoYes069
34R:R:F322 R:R:M318 43.62716.22NoYes068
35R:R:F80 R:R:Y85 37.32029.28YesNo089
36R:R:I84 R:R:Y85 70.74473.63NoNo089
37R:R:E145 R:R:I84 66.96128.2YesNo088
38R:R:E145 R:R:V164 34.02084.28YesNo087
39R:R:P83 R:R:V164 26.75195.3NoNo067
40R:R:M159 R:R:P83 19.123410.06NoNo066
41R:R:M159 R:R:N161 15.30464.21NoNo063
42R:R:N161 R:R:Y86 11.48279.3NoNo034
43R:R:D315 R:R:M318 38.9234.16NoYes088
44R:R:D315 R:R:Y85 37.04675.75NoNo089
45R:R:L139 R:R:N303 19.82734.12YesYes189
46R:R:L139 R:R:Y311 11.61484.69YesYes189
47R:R:L91 R:R:N138 16.61545.49YesYes198
48R:R:L116 R:R:W121 18.26284.56NoYes069
49R:R:L116 R:R:T120 17.06114.42NoNo064
50R:R:T117 R:R:T120 11.37666.28NoNo064
51R:R:L122 R:R:Y202 10.91713.52NoYes054
52R:R:W210 R:R:Y206 22.70416.75YesYes167
53R:R:N214 R:R:W210 24.01346.78YesYes176
54R:R:V136 R:R:W271 31.84324.9YesYes188
55R:R:N214 R:R:V136 11.87158.87YesYes178
56R:R:T217 R:R:V136 53.87884.76YesYes078
57R:R:M178 R:R:W210 12.88578.14YesYes156
58R:R:F213 R:R:M178 11.93293.73NoYes055
59R:R:F213 R:R:T217 23.22355.19NoYes057
60R:R:F213 R:R:N214 12.18047.25NoYes057
61R:R:L140 R:R:T217 73.375610.32NoYes077
62R:R:L140 R:R:V220 69.67212.98NoNo075
63R:R:L224 R:R:V220 67.81572.98NoNo065
64R:R:H147 R:R:L224 64.093611.57YesNo076
65R:R:F151 R:R:H147 35.737313.58YesYes467
66R:R:H147 R:R:I228 24.58813.98YesNo079
67R:R:E145 R:R:R163 11.13388.14YesNo086
68R:R:E145 R:R:T149 14.70374.23YesNo088
69R:R:R152 R:R:T149 11.13549.06NoNo058
70R:R:F151 R:R:V150 22.63343.93YesNo068
71R:R:I228 R:R:V150 22.68724.61NoNo098
72R:R:F151 R:R:Y231 11.465814.44YesNo066
73R:R:D129 R:R:Y202 14.33345.75YesYes154
74R:R:E293 R:R:M198 17.738813.53YesNo043
75R:R:L277 R:R:M198 16.69847.07NoNo043
76R:R:V150 R:R:V232 41.46941.6NoNo087
77R:R:L256 R:R:V232 30.47854.47NoNo077
78R:R:F229 R:R:L256 26.99476.09YesNo067
79R:R:F229 R:R:L257 11.58568.53YesNo067
80R:R:L277 R:R:Y292 10.33784.69NoNo043
81R:R:W121 R:R:Y202 15.51673.86YesYes194
82R:R:Y202 R:R:Y206 14.22124.96YesYes147
83R:R:D129 R:R:W210 14.531613.4YesYes156
84R:R:F267 R:R:N303 11.59953.62YesYes199
85R:R:F267 R:R:V136 11.52427.87YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y34 6.71 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 9.08 1 Yes Yes 0 8 0 1
L:L:?1 R:R:T109 7.38 1 Yes No 0 5 0 1
L:L:?1 R:R:T113 6.33 1 Yes No 0 5 0 1
L:L:?1 R:R:R124 11.3 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q125 18.1 1 Yes Yes 0 4 0 1
L:L:?1 R:R:D129 12.62 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L132 3.96 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W210 13.85 1 Yes Yes 0 6 0 1
L:L:?1 R:R:E293 9.48 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K294 7.06 1 Yes No 0 4 0 1
L:L:?1 R:R:L297 9.9 1 Yes No 0 6 0 1
R:R:I30 R:R:Y34 3.63 1 No Yes 6 6 2 1
R:R:I30 R:R:W121 4.7 1 No Yes 6 9 2 2
R:R:L41 R:R:Y34 4.69 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 4.99 1 No Yes 5 6 1 1
R:R:W121 R:R:Y34 11.58 1 Yes Yes 9 6 2 1
R:R:P200 R:R:Y34 8.34 0 No Yes 6 6 2 1
R:R:K39 R:R:P200 10.04 1 Yes No 8 6 1 2
R:R:K39 R:R:L290 4.23 1 Yes No 8 3 1 2
R:R:E293 R:R:K39 6.75 1 Yes Yes 4 8 1 1
R:R:K294 R:R:V52 9.11 0 No No 4 5 1 2
R:R:L105 R:R:Y102 3.52 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 5.86 0 No Yes 6 7 1 2
R:R:E301 R:R:Y102 12.35 0 No Yes 7 7 2 2
R:R:L105 R:R:R124 9.72 0 No Yes 6 6 2 1
R:R:N108 R:R:R124 13.26 0 No Yes 5 6 2 1
R:R:G110 R:R:T109 5.46 0 No No 5 5 2 1
R:R:R124 R:R:W121 13 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 13.14 1 Yes Yes 4 9 1 2
R:R:W121 R:R:Y202 3.86 1 Yes Yes 9 4 2 2
R:R:Q125 R:R:R124 3.5 1 Yes Yes 4 6 1 1
R:R:Q125 R:R:Y202 9.02 1 Yes Yes 4 4 1 2
R:R:D129 R:R:Y202 5.75 1 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 10.34 1 Yes Yes 5 7 1 2
R:R:D129 R:R:W210 13.4 1 Yes Yes 5 6 1 1
R:R:L132 R:R:S131 4.5 0 Yes No 7 6 1 2
R:R:L132 R:R:W271 7.97 0 Yes Yes 7 8 1 2
R:R:E301 R:R:L132 11.93 0 No Yes 7 7 2 1
R:R:M178 R:R:T133 7.53 1 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 1 No Yes 6 6 2 1
R:R:M178 R:R:W210 8.14 1 Yes Yes 5 6 2 1
R:R:L207 R:R:S196 4.5 0 No No 6 5 1 2
R:R:E293 R:R:M198 13.53 1 Yes No 4 3 1 2
R:R:Y202 R:R:Y206 4.96 1 Yes Yes 4 7 2 2
R:R:W210 R:R:Y206 6.75 1 Yes Yes 6 7 1 2
R:R:D281 R:R:L207 4.07 0 No No 4 6 2 1
R:R:N214 R:R:W210 6.78 1 Yes Yes 7 6 2 1
R:R:W210 R:R:W271 5.62 1 Yes Yes 6 8 1 2
R:R:A211 R:R:L278 4.73 0 No No 4 6 2 1
R:R:N214 R:R:W271 7.91 1 Yes Yes 7 8 2 2
R:R:E293 R:R:L290 6.63 1 Yes No 4 3 1 2
L:L:?1 R:R:L207 2.97 1 Yes No 0 6 0 1
L:L:?1 R:R:L278 2.97 1 Yes No 0 6 0 1
L:L:?1 R:R:G274 2.45 1 Yes No 0 5 0 1
L:L:?1 R:R:A300 2.25 1 Yes No 0 7 0 1
R:R:D129 R:R:G126 1.68 1 Yes No 5 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9IZF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.39
Number of Linked Nodes 270
Number of Links 312
Number of Hubs 42
Number of Links mediated by Hubs 158
Number of Communities 6
Number of Nodes involved in Communities 56
Number of Links involved in Communities 86
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 145938
Length Of Smallest Path 3
Average Path Length 15.8512
Length of Longest Path 33
Minimum Path Strength 1.465
Average Path Strength 7.10538
Maximum Path Strength 18.3
Minimum Path Correlation 0.7
Average Path Correlation 0.92865
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 44.8958
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.7134
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNKP
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeNKP
Name(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms18:1 LPA; oleoyl lysophosphatidic acid
Identifier
FormulaC21 H41 O7 P
Molecular Weight436.52
SMILES
PubChem49837858
Formal Charge0
Total Atoms70
Total Chiral Atoms1
Total Bonds69
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ92633
Sequence
>9IZF_nogp_Chain_R
SIAFFYNRS GKHLATEWN TVSKLVMGL GITVCIFIM LANLLVMVA 
IYVNRRFHF PIYYLMANL AAADFFAGL AYFYLMFNT GPNTRRLTV 
STWLLRQGL IDTSLTASV ANLLAIAIE RHITVFRMQ LHTRMSNRR 
VVVVIVVIW TMAIVMGAI PSVGWNCIC DIENCSNMA PLYSDSYLV 
FWAIFNLVT FVVMVVLYA HIFGYVRQR TMRMSRHDT MMSLLKTVV 
IVLGAFIIC WTPGLVLLL LDVCCPQCD VLAYEKFFL LLAEFNSAM 
NPIIYSYRD KEMSATFRQ ILC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4Z34ALipidLysophospholipidLPA1Homo sapiensONO-9780307--32015-06-03doi.org/10.1016/j.cell.2015.06.002
4Z35ALipidLysophospholipidLPA1Homo sapiensONO-9910539--2.92015-06-03doi.org/10.1016/j.cell.2015.06.002
4Z36ALipidLysophospholipidLPA1Homo sapiensONO-3080573--2.92015-06-03doi.org/10.1016/j.cell.2015.06.002
9IZFALipidLysophospholipidLPA1Homo sapiensNKP-Gi1/β1/γ23.142025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZF (No Gprot) ALipidLysophospholipidLPA1Homo sapiensNKP-3.142025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZGALipidLysophospholipidLPA1Homo sapiensNKP-chim(NtGi1-Gs-CtGq)/β1/γ23.042025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZG (No Gprot) ALipidLysophospholipidLPA1Homo sapiensNKP-3.042025-01-01doi.org/10.1016/j.jsb.2024.108164
7TD0ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ22.832022-02-09doi.org/10.1038/s41467-022-28417-2
7TD0 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-2.832022-02-09doi.org/10.1038/s41467-022-28417-2
7TD1ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.082022-02-09doi.org/10.1038/s41467-022-28417-2
7TD1 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.082022-02-09doi.org/10.1038/s41467-022-28417-2
7TD2ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.112022-02-09doi.org/10.1038/s41467-022-28417-2
7TD2 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.112022-02-09doi.org/10.1038/s41467-022-28417-2
7YU3ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU3 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU4ALipidLysophospholipidLPA1Homo sapiensONO-0740556--3.72022-10-05doi.org/10.1038/s41467-022-33121-2
7YU5ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.72022-10-05doi.org/10.1038/s41467-022-33121-2
7YU5 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.72022-10-05doi.org/10.1038/s41467-022-33121-2
7YU6ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.92022-10-05doi.org/10.1038/s41467-022-33121-2
7YU6 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-3.92022-10-05doi.org/10.1038/s41467-022-33121-2
7YU7ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ24.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU7 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-4.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU8ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ25.62022-10-05doi.org/10.1038/s41467-022-33121-2
7YU8 (No Gprot) ALipidLysophospholipidLPA1Homo sapiensONO-0740556-5.62022-10-05doi.org/10.1038/s41467-022-33121-2
9J5VALipidLysophospholipidLPA1Homo sapiensCpY-Gi1/β1/γ22.862024-11-27doi.org/10.1038/s42003-024-07152-y
9J5V (No Gprot) ALipidLysophospholipidLPA1Homo sapiensCpY-2.862024-11-27doi.org/10.1038/s42003-024-07152-y
9IZHALipidLysophospholipidLPA1Homo sapiensLPA-chim(NtGi2-G13)/β1/γ23.042025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZH (No Gprot) ALipidLysophospholipidLPA1Homo sapiensLPA-3.042025-01-01doi.org/10.1016/j.jsb.2024.108164




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Download 9IZF_nogp.zip



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