psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	6.71	Yes	Yes	1	0	6
2	L:L:?1	R:R:K39	9.08	Yes	Yes	1	0	8
3	L:L:?1	R:R:T109	7.38	Yes	No	0	0	5
4	L:L:?1	R:R:T113	6.33	Yes	No	1	0	5
5	L:L:?1	R:R:R124	11.3	Yes	Yes	1	0	6
6	L:L:?1	R:R:Q125	18.1	Yes	Yes	1	0	4
7	L:L:?1	R:R:D129	12.62	Yes	Yes	1	0	5
8	L:L:?1	R:R:L132	3.96	Yes	Yes	0	0	7
9	L:L:?1	R:R:W210	13.85	Yes	Yes	1	0	6
10	L:L:?1	R:R:E293	9.48	Yes	Yes	1	0	4
11	L:L:?1	R:R:K294	7.06	Yes	No	0	0	4
12	L:L:?1	R:R:L297	9.9	Yes	No	0	0	6
13	R:R:I30	R:R:Y34	3.63	No	Yes	1	6	6
14	R:R:I30	R:R:W121	4.7	No	Yes	1	6	9
15	R:R:F32	R:R:F33	7.5	No	No	0	2	6
16	R:R:F32	R:R:R36	8.55	No	No	0	2	3
17	R:R:F33	R:R:I189	6.28	No	No	0	6	3
18	R:R:F33	R:R:L201	14.61	No	Yes	0	6	1
19	R:R:L41	R:R:Y34	4.69	No	Yes	0	2	6
20	R:R:T113	R:R:Y34	4.99	No	Yes	1	5	6
21	R:R:W121	R:R:Y34	11.58	Yes	Yes	1	9	6
22	R:R:P200	R:R:Y34	8.34	No	Yes	0	6	6
23	R:R:I192	R:R:R36	10.02	No	No	0	1	3
24	R:R:P200	R:R:S37	5.34	No	No	0	6	7
25	R:R:K39	R:R:P200	10.04	Yes	No	0	8	6
26	R:R:K39	R:R:L290	4.23	Yes	No	1	8	3
27	R:R:E293	R:R:K39	6.75	Yes	Yes	1	4	8
28	R:R:E44	R:R:T43	7.06	No	No	0	1	3
29	R:R:R114	R:R:T43	10.35	No	No	0	6	3
30	R:R:K50	R:R:W45	5.8	No	No	0	3	1
31	R:R:M53	R:R:W45	4.65	No	No	0	4	1
32	R:R:P111	R:R:W45	20.27	No	No	0	4	1
33	R:R:N46	R:R:V48	4.43	No	No	0	2	3
34	R:R:F295	R:R:L51	3.65	No	No	0	4	4
35	R:R:K294	R:R:V52	9.11	No	No	0	4	5
36	R:R:L298	R:R:L55	4.15	No	No	0	6	4
37	R:R:G56	R:R:M106	3.49	No	Yes	0	6	6
38	R:R:L298	R:R:V59	4.47	No	No	0	6	7
39	R:R:C60	R:R:Y102	5.38	No	Yes	3	6	7
40	R:R:C60	R:R:F103	5.59	No	No	0	6	6
41	R:R:C60	R:R:M106	4.86	No	Yes	3	6	6
42	R:R:G99	R:R:I63	3.53	No	No	0	7	8
43	R:R:F96	R:R:M64	7.46	No	No	0	7	6
44	R:R:L100	R:R:M64	7.07	No	No	0	4	6
45	R:R:A66	R:R:P308	3.74	No	No	0	8	9
46	R:R:A92	R:R:N67	4.69	No	No	0	9	9
47	R:R:D95	R:R:N67	12.12	Yes	No	0	9	9
48	R:R:N67	R:R:P308	14.66	No	No	0	9	9
49	R:R:F96	R:R:L68	3.65	No	No	0	7	4
50	R:R:A92	R:R:V70	3.39	No	Yes	0	9	9
51	R:R:S312	R:R:V70	4.85	No	Yes	0	7	9
52	R:R:F322	R:R:V70	3.93	No	Yes	0	6	9
53	R:R:A89	R:R:I74	4.87	No	No	0	7	7
54	R:R:N77	R:R:R79	15.67	No	No	2	6	6
55	R:R:F80	R:R:N77	13.29	Yes	No	2	8	6
56	R:R:H81	R:R:R78	13.54	No	No	0	8	6
57	R:R:F80	R:R:R79	6.41	Yes	No	2	8	6
58	R:R:E317	R:R:R79	20.93	No	No	2	7	6
59	R:R:F80	R:R:Y85	9.28	Yes	No	0	8	9
60	R:R:E317	R:R:F80	4.66	No	Yes	2	7	8
61	R:R:F80	R:R:M318	11.2	Yes	Yes	0	8	8
62	R:R:F80	R:R:T321	3.89	Yes	No	0	8	7
63	R:R:H81	R:R:Y86	6.53	No	No	0	8	4
64	R:R:F82	R:R:P83	4.33	No	No	0	7	6
65	R:R:M159	R:R:P83	10.06	No	No	0	6	6
66	R:R:P83	R:R:V164	5.3	No	No	0	6	7
67	R:R:I84	R:R:Y85	3.63	No	No	0	8	9
68	R:R:E145	R:R:I84	8.2	Yes	No	0	8	8
69	R:R:D315	R:R:Y85	5.75	No	No	0	8	9
70	R:R:N161	R:R:Y86	9.3	No	No	0	3	4
71	R:R:E145	R:R:L87	5.3	Yes	No	0	8	8
72	R:R:M88	R:R:R146	3.72	No	Yes	1	8	9
73	R:R:M88	R:R:Y311	3.59	No	Yes	1	8	9
74	R:R:N138	R:R:N90	16.35	Yes	Yes	1	8	9
75	R:R:I168	R:R:N90	15.58	No	Yes	0	8	9
76	R:R:I171	R:R:N90	5.66	Yes	Yes	1	7	9
77	R:R:N90	R:R:W172	9.04	Yes	No	0	9	9
78	R:R:D95	R:R:L91	8.14	Yes	Yes	1	9	9
79	R:R:L91	R:R:N138	5.49	Yes	Yes	1	9	8
80	R:R:L139	R:R:L91	5.54	Yes	Yes	1	8	9
81	R:R:L91	R:R:N307	8.24	Yes	Yes	1	9	9
82	R:R:L91	R:R:Y311	3.52	Yes	Yes	1	9	9
83	R:R:D95	R:R:S135	7.36	Yes	No	1	9	9
84	R:R:D95	R:R:S304	7.36	Yes	Yes	1	9	9
85	R:R:D95	R:R:N307	9.42	Yes	Yes	1	9	9
86	R:R:F97	R:R:L127	6.09	No	No	0	7	5
87	R:R:F97	R:R:T130	3.89	No	No	0	7	6
88	R:R:A98	R:R:S131	3.42	No	No	0	8	6
89	R:R:A98	R:R:S304	3.42	No	Yes	0	8	9
90	R:R:A101	R:R:S131	3.42	No	No	0	5	6
91	R:R:L105	R:R:Y102	3.52	No	Yes	0	6	7
92	R:R:M106	R:R:Y102	8.38	Yes	Yes	3	6	7
93	R:R:L297	R:R:Y102	5.86	No	Yes	0	6	7
94	R:R:L298	R:R:Y102	4.69	No	Yes	0	6	7
95	R:R:E301	R:R:Y102	12.35	No	Yes	0	7	7
96	R:R:F103	R:R:F107	4.29	No	No	0	6	5
97	R:R:N108	R:R:Y104	3.49	No	No	0	5	5
98	R:R:L123	R:R:Y104	3.52	No	No	0	4	5
99	R:R:L105	R:R:R124	9.72	No	Yes	0	6	6
100	R:R:I128	R:R:L105	8.56	No	No	0	6	6
101	R:R:L116	R:R:N108	12.36	No	No	0	6	5
102	R:R:N108	R:R:R124	13.26	No	Yes	0	5	6
103	R:R:G110	R:R:T109	5.46	No	No	0	5	5
104	R:R:G110	R:R:P111	4.06	No	No	0	5	4
105	R:R:N112	R:R:R115	12.05	No	No	0	4	3
106	R:R:R114	R:R:R115	5.33	No	No	0	6	3
107	R:R:L116	R:R:T120	4.42	No	No	0	6	4
108	R:R:L116	R:R:W121	4.56	No	Yes	0	6	9
109	R:R:T117	R:R:T120	6.28	No	No	0	6	4
110	R:R:R124	R:R:W121	13	Yes	Yes	1	6	9
111	R:R:Q125	R:R:W121	13.14	Yes	Yes	1	4	9
112	R:R:L201	R:R:W121	13.67	Yes	Yes	0	1	9
113	R:R:W121	R:R:Y202	3.86	Yes	Yes	1	9	4
114	R:R:L122	R:R:L201	4.15	No	Yes	0	5	1
115	R:R:L122	R:R:Y202	3.52	No	Yes	0	5	4
116	R:R:Q125	R:R:R124	3.5	Yes	Yes	1	4	6
117	R:R:Q125	R:R:Y202	9.02	Yes	Yes	1	4	4
118	R:R:E301	R:R:I128	8.2	No	No	0	7	6
119	R:R:D129	R:R:Y202	5.75	Yes	Yes	1	5	4
120	R:R:D129	R:R:Y206	10.34	Yes	Yes	1	5	7
121	R:R:D129	R:R:W210	13.4	Yes	Yes	1	5	6
122	R:R:G179	R:R:T130	3.64	No	No	0	7	6
123	R:R:L132	R:R:S131	4.5	Yes	No	0	7	6
124	R:R:L132	R:R:W271	7.97	Yes	Yes	0	7	8
125	R:R:E301	R:R:L132	11.93	No	Yes	0	7	7
126	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
127	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
128	R:R:A134	R:R:W172	3.89	No	No	0	7	9
129	R:R:S135	R:R:S304	4.89	No	Yes	1	9	9
130	R:R:N214	R:R:V136	8.87	Yes	Yes	1	7	8
131	R:R:T217	R:R:V136	4.76	Yes	Yes	0	7	8
132	R:R:F267	R:R:V136	7.87	Yes	Yes	1	9	8
133	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
134	R:R:A137	R:R:I171	4.87	No	Yes	0	5	7
135	R:R:I171	R:R:N138	12.74	Yes	Yes	1	7	8
136	R:R:L139	R:R:N303	4.12	Yes	Yes	1	8	9
137	R:R:L139	R:R:N307	12.36	Yes	Yes	1	8	9
138	R:R:L139	R:R:Y311	4.69	Yes	Yes	1	8	9
139	R:R:I144	R:R:L140	5.71	No	No	0	6	7
140	R:R:L140	R:R:T217	10.32	No	Yes	0	7	7
141	R:R:I142	R:R:R146	6.26	No	Yes	1	8	9
142	R:R:I142	R:R:Y311	7.25	No	Yes	1	8	9
143	R:R:A143	R:R:Y225	5.34	No	Yes	0	8	9
144	R:R:E145	R:R:T149	4.23	Yes	No	0	8	8
145	R:R:E145	R:R:R163	8.14	Yes	No	0	8	6
146	R:R:E145	R:R:V164	4.28	Yes	No	0	8	7
147	R:R:R146	R:R:Y225	9.26	Yes	Yes	1	9	9
148	R:R:R146	R:R:Y311	8.23	Yes	Yes	1	9	9
149	R:R:R146	R:R:R314	4.26	Yes	No	0	9	7
150	R:R:F151	R:R:H147	13.58	Yes	Yes	4	6	7
151	R:R:H147	R:R:L224	11.57	Yes	No	0	7	6
152	R:R:H147	R:R:H227	10.75	Yes	No	4	7	5
153	R:R:H147	R:R:I228	3.98	Yes	No	0	7	9
154	R:R:I148	R:R:R163	3.76	No	No	0	5	6
155	R:R:R152	R:R:T149	9.06	No	No	0	5	8
156	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
157	R:R:I228	R:R:V150	4.61	No	No	0	9	8
158	R:R:F151	R:R:H227	15.84	Yes	No	4	6	5
159	R:R:F151	R:R:Y231	14.44	Yes	No	0	6	6
160	R:R:R152	R:R:T157	14.23	No	No	0	5	4
161	R:R:M153	R:R:Y231	3.59	No	No	0	7	6
162	R:R:Q154	R:R:T157	8.5	No	No	0	4	4
163	R:R:H156	R:R:L155	7.71	No	No	0	4	8
164	R:R:M159	R:R:N161	4.21	No	No	0	6	3
165	R:R:R162	R:R:V166	3.92	No	No	0	5	3
166	R:R:F209	R:R:M178	3.73	No	Yes	0	6	5
167	R:R:M178	R:R:W210	8.14	Yes	Yes	1	5	6
168	R:R:F213	R:R:M178	3.73	No	Yes	0	5	5
169	R:R:I181	R:R:P182	3.39	No	No	0	5	6
170	R:R:P182	R:R:Y202	11.13	No	Yes	1	6	4
171	R:R:P182	R:R:Y206	9.74	No	Yes	1	6	7
172	R:R:W186	R:R:Y206	4.82	No	Yes	0	6	7
173	R:R:I189	R:R:N187	7.08	No	No	0	3	6
174	R:R:C188	R:R:C195	7.28	No	No	0	5	9
175	R:R:D191	R:R:N194	4.04	No	No	0	4	3
176	R:R:E193	R:R:N194	5.26	No	No	0	4	3
177	R:R:D204	R:R:N194	8.08	No	No	0	4	3
178	R:R:L207	R:R:S196	4.5	No	No	0	6	5
179	R:R:D281	R:R:N197	5.39	No	No	0	4	5
180	R:R:L277	R:R:M198	7.07	No	No	0	4	3
181	R:R:E293	R:R:M198	13.53	Yes	No	0	4	3
182	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
183	R:R:Y202	R:R:Y206	4.96	Yes	Yes	1	4	7
184	R:R:S203	R:R:S205	4.89	No	No	0	5	5
185	R:R:W210	R:R:Y206	6.75	Yes	Yes	1	6	7
186	R:R:D281	R:R:L207	4.07	No	No	0	4	6
187	R:R:V208	R:R:V282	4.81	No	No	0	4	5
188	R:R:N214	R:R:W210	6.78	Yes	Yes	1	7	6
189	R:R:W210	R:R:W271	5.62	Yes	Yes	1	6	8
190	R:R:A211	R:R:L278	4.73	No	No	0	4	6
191	R:R:F213	R:R:N214	7.25	No	Yes	0	5	7
192	R:R:F213	R:R:T217	5.19	No	Yes	0	5	7
193	R:R:N214	R:R:W271	7.91	Yes	Yes	1	7	8
194	R:R:L275	R:R:N214	6.87	No	Yes	0	6	7
195	R:R:F218	R:R:V222	5.24	Yes	No	1	5	4
196	R:R:F218	R:R:L264	4.87	Yes	No	1	5	7
197	R:R:F218	R:R:F267	9.65	Yes	Yes	1	5	9
198	R:R:F218	R:R:I268	7.54	Yes	No	0	5	6
199	R:R:L264	R:R:V222	5.96	No	No	1	7	4
200	R:R:V260	R:R:Y225	3.79	No	Yes	0	8	9
201	R:R:V263	R:R:Y225	8.83	No	Yes	1	8	9
202	R:R:L264	R:R:Y225	4.69	No	Yes	1	7	9
203	R:R:Y225	R:R:Y311	4.96	Yes	Yes	1	9	9
204	R:R:F229	R:R:M253	6.22	Yes	No	0	6	7
205	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
206	R:R:F229	R:R:L257	8.53	Yes	No	0	6	7
207	R:R:R235	R:R:Y231	13.38	No	No	0	7	6
208	R:R:L256	R:R:V232	4.47	No	No	0	7	7
209	R:R:M253	R:R:R233	4.96	No	No	0	7	5
210	R:R:Q234	R:R:R235	15.19	No	No	0	4	7
211	R:R:R235	R:R:R238	7.46	No	No	0	7	5
212	R:R:H242	R:R:M239	3.94	No	No	0	4	7
213	R:R:R241	R:R:S240	5.27	No	No	0	4	4
214	R:R:I262	R:R:K258	4.36	No	No	5	6	7
215	R:R:K258	R:R:Y313	4.78	No	No	5	7	5
216	R:R:R314	R:R:T259	12.94	No	No	0	7	8
217	R:R:I262	R:R:Y313	6.04	No	No	5	6	5
218	R:R:V263	R:R:Y311	6.31	No	Yes	1	8	9
219	R:R:G265	R:R:I268	3.53	No	No	0	4	6
220	R:R:F267	R:R:W271	17.04	Yes	Yes	1	9	8
221	R:R:F267	R:R:N303	3.62	Yes	Yes	1	9	9
222	R:R:C270	R:R:I269	4.91	No	No	0	9	5
223	R:R:N303	R:R:W271	9.04	Yes	Yes	1	9	8
224	R:R:P273	R:R:T272	3.5	No	No	0	9	5
225	R:R:F296	R:R:P273	8.67	No	No	6	5	9
226	R:R:L299	R:R:P273	6.57	No	No	6	7	9
227	R:R:L277	R:R:Y292	4.69	No	No	0	4	3
228	R:R:F296	R:R:L277	7.31	No	No	0	5	4
229	R:R:D288	R:R:L280	6.79	No	No	0	1	5
230	R:R:D281	R:R:V282	4.38	No	No	0	4	5
231	R:R:C283	R:R:V282	3.42	No	No	0	4	5
232	R:R:C284	R:R:C287	7.28	No	No	0	4	5
233	R:R:D288	R:R:Y292	11.49	No	No	0	1	3
234	R:R:V289	R:R:Y292	5.05	No	No	0	4	3
235	R:R:E293	R:R:L290	6.63	Yes	No	1	4	3
236	R:R:F296	R:R:L299	4.87	No	No	6	5	7
237	R:R:F302	R:R:M306	4.98	No	Yes	0	5	6
238	R:R:N303	R:R:N307	12.26	Yes	Yes	1	9	9
239	R:R:I310	R:R:Y311	4.84	No	Yes	0	8	9
240	R:R:M318	R:R:S312	4.6	Yes	No	0	8	7
241	R:R:R314	R:R:Y313	13.38	No	No	0	7	5
242	R:R:D315	R:R:M318	4.16	No	Yes	0	8	8
243	R:R:F322	R:R:M318	6.22	No	Yes	0	6	8
244	R:R:A305	R:R:I63	3.25	No	No	0	7	8
245	R:R:A141	R:R:I171	3.25	No	Yes	0	8	7
246	R:R:C270	R:R:M306	3.24	No	Yes	0	9	6
247	R:R:A93	R:R:M71	3.22	No	No	0	6	7
248	R:R:A266	R:R:M306	3.22	No	Yes	0	6	6
249	R:R:T236	R:R:V232	3.17	No	No	0	5	7
250	R:R:A101	R:R:L127	3.15	No	No	0	5	5
251	R:R:T236	R:R:T252	3.14	No	No	0	5	5
252	R:R:A94	R:R:N138	3.13	No	Yes	0	8	8
253	R:R:C190	R:R:D191	3.11	No	No	0	3	4
254	R:R:I63	R:R:S304	3.1	No	Yes	0	8	9
255	R:R:I171	R:R:V167	3.07	Yes	No	0	7	6
256	R:R:I181	R:R:V177	3.07	No	No	0	5	4
257	R:R:M221	R:R:T217	3.01	No	Yes	0	9	7
258	R:R:N46	R:R:S49	2.98	No	No	0	2	1
259	R:R:L201	R:R:V118	2.98	Yes	No	0	1	2
260	R:R:L140	R:R:V220	2.98	No	No	0	7	5
261	R:R:L224	R:R:V220	2.98	No	No	0	6	5
262	L:L:?1	R:R:L207	2.97	Yes	No	0	0	6
263	L:L:?1	R:R:L278	2.97	Yes	No	0	0	6
264	R:R:A42	R:R:H40	2.93	No	No	0	4	2
265	R:R:N46	R:R:T47	2.92	No	No	0	2	5
266	R:R:I57	R:R:M106	2.92	No	Yes	0	4	6
267	R:R:I310	R:R:M306	2.92	No	Yes	0	8	6
268	R:R:I61	R:R:L65	2.85	No	No	0	4	4
269	R:R:I325	R:R:L69	2.85	No	No	0	6	7
270	R:R:L257	R:R:M254	2.83	No	No	0	7	5
271	R:R:L51	R:R:L55	2.77	No	No	0	4	4
272	R:R:A66	R:R:F62	2.77	No	No	0	8	4
273	R:R:A73	R:R:F322	2.77	No	No	0	7	6
274	R:R:M237	R:R:Q234	2.72	No	No	0	5	4
275	R:R:R163	R:R:S160	2.64	No	No	0	6	8
276	R:R:F62	R:R:I309	2.51	No	No	0	4	7
277	R:R:S205	R:R:W186	2.47	No	No	0	5	6
278	L:L:?1	R:R:G274	2.45	Yes	No	0	0	5
279	L:L:?1	R:R:A300	2.25	Yes	No	0	0	7
280	R:R:C284	R:R:P285	1.88	No	No	0	4	3
281	R:R:G110	R:R:S49	1.86	No	No	0	5	1
282	R:R:A134	R:R:A175	1.79	No	No	0	7	8
283	R:R:G99	R:R:M64	1.75	No	No	0	7	6
284	R:R:C195	R:R:S37	1.72	No	No	0	9	7
285	R:R:C188	R:R:S203	1.72	No	No	0	5	5
286	R:R:A42	R:R:S49	1.71	No	No	0	4	1
287	R:R:A180	R:R:S183	1.71	No	No	0	4	6
288	R:R:A291	R:R:V289	1.7	No	No	0	2	4
289	R:R:D129	R:R:G126	1.68	Yes	No	0	5	6
290	R:R:A73	R:R:I325	1.62	No	No	0	7	6
291	R:R:A92	R:R:M71	1.61	No	No	0	9	7
292	R:R:V72	R:R:V76	1.6	No	No	0	5	5
293	R:R:S119	R:R:T117	1.6	No	No	0	1	6
294	R:R:V150	R:R:V232	1.6	No	No	0	8	7
295	R:R:V164	R:R:V165	1.6	No	No	0	7	1
296	R:R:C287	R:R:L280	1.59	No	No	0	5	5
297	R:R:A211	R:R:L279	1.58	No	No	0	4	6
298	R:R:A31	R:R:N35	1.56	No	No	0	2	7
299	R:R:I74	R:R:V70	1.54	No	Yes	0	7	9
300	R:R:I212	R:R:V216	1.54	No	No	0	4	4
301	R:R:I176	R:R:T130	1.52	No	No	0	3	6
302	R:R:M174	R:R:T133	1.51	No	No	0	4	6
303	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
304	R:R:L68	R:R:V72	1.49	No	No	0	4	5
305	R:R:L224	R:R:V223	1.49	No	No	0	6	4
306	R:R:L257	R:R:V261	1.49	No	No	0	7	5
307	R:R:L55	R:R:T58	1.47	No	No	0	4	5
308	R:R:D204	R:R:S205	1.47	No	No	0	4	5
309	R:R:P111	R:R:R114	1.44	No	No	0	4	6
310	R:R:I212	R:R:L215	1.43	No	No	0	4	5
311	R:R:L41	R:R:N35	1.37	No	No	0	2	7
312	R:R:F32	R:R:S29	1.32	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.90062	16	1	0
2	R:R:Y34	6.65667	6	1	6
3	R:R:K39	7.525	4	1	8
4	R:R:V70	3.4275	4	0	9
5	R:R:F80	8.12167	6	2	8
6	R:R:N90	11.6575	4	1	9
7	R:R:L91	6.186	5	1	9
8	R:R:D95	8.88	5	1	9
9	R:R:Y102	6.69667	6	3	7
10	R:R:M106	4.9125	4	3	6
11	R:R:W121	9.21571	7	1	9
12	R:R:R124	10.156	5	1	6
13	R:R:Q125	10.94	4	1	4
14	R:R:D129	8.758	5	1	5
15	R:R:L132	7.09	4	0	7
16	R:R:V136	6.6	4	1	8
17	R:R:N138	9.4275	4	1	8
18	R:R:L139	6.6775	4	1	8
19	R:R:E145	6.03	5	0	8
20	R:R:R146	6.346	5	1	9
21	R:R:H147	9.97	4	4	7
22	R:R:F151	11.9475	4	4	6
23	R:R:I171	5.918	5	1	7
24	R:R:M178	5.7825	4	1	5
25	R:R:L201	8.8525	4	0	1
26	R:R:Y202	6.03429	7	1	4
27	R:R:Y206	7.322	5	1	7
28	R:R:W210	8.65714	7	1	6
29	R:R:N214	7.536	5	1	7
30	R:R:T217	5.82	4	0	7
31	R:R:F218	6.825	4	1	5
32	R:R:Y225	6.145	6	1	9
33	R:R:F229	5.5875	4	0	6
34	R:R:F267	9.545	4	1	9
35	R:R:W271	8.74667	6	1	8
36	R:R:E293	9.0975	4	1	4
37	R:R:N303	7.26	4	1	9
38	R:R:S304	4.6925	4	1	9
39	R:R:M306	3.59	4	0	6
40	R:R:N307	10.57	4	1	9
41	R:R:Y311	5.42375	8	1	9
42	R:R:M318	6.545	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y34	25.0707	6.71	Yes	Yes	1	0	6
2	L:L:?1	R:R:R124	26.0312	11.3	Yes	Yes	1	0	6
3	R:R:R124	R:R:W121	16.5417	13	Yes	Yes	1	6	9
4	R:R:W121	R:R:Y34	16.156	11.58	Yes	Yes	1	9	6
5	R:R:L201	R:R:W121	40.5674	13.67	Yes	Yes	0	1	9
6	R:R:F33	R:R:L201	39.2304	14.61	No	Yes	0	6	1
7	R:R:F32	R:R:F33	22.4351	7.5	No	No	0	2	6
8	L:L:?1	R:R:Q125	17.3854	18.1	Yes	Yes	1	0	4
9	R:R:Q125	R:R:W121	15.6857	13.14	Yes	Yes	1	4	9
10	R:R:F32	R:R:R36	11.223	8.55	No	No	0	2	3
11	R:R:F33	R:R:I189	11.223	6.28	No	No	0	6	3
12	L:L:?1	R:R:E293	19.8872	9.48	Yes	Yes	1	0	4
13	L:L:?1	R:R:T109	21.7052	7.38	Yes	No	0	0	5
14	R:R:G110	R:R:T109	20.5787	5.46	No	No	0	5	5
15	R:R:G110	R:R:P111	11.6717	4.06	No	No	0	5	4
16	L:L:?1	R:R:L132	60.6666	3.96	Yes	Yes	0	0	7
17	R:R:L132	R:R:S131	29.3967	4.5	Yes	No	0	7	6
18	R:R:A98	R:R:S131	28.1381	3.42	No	No	0	8	6
19	R:R:A98	R:R:S304	27.989	3.42	No	Yes	0	8	9
20	R:R:D95	R:R:S304	27.8953	7.36	Yes	Yes	1	9	9
21	R:R:D95	R:R:N67	100	12.12	Yes	No	0	9	9
22	R:R:L132	R:R:W271	44.2756	7.97	Yes	Yes	0	7	8
23	R:R:N303	R:R:W271	88.1946	9.04	Yes	Yes	1	9	8
24	R:R:N303	R:R:N307	79.5765	12.26	Yes	Yes	1	9	9
25	R:R:D95	R:R:N307	71.7006	9.42	Yes	Yes	1	9	9
26	L:L:?1	R:R:W210	61.6824	13.85	Yes	Yes	1	0	6
27	R:R:W210	R:R:W271	59.9843	5.62	Yes	Yes	1	6	8
28	R:R:A92	R:R:N67	96.1735	4.69	No	No	0	9	9
29	R:R:A92	R:R:V70	93.8407	3.39	No	Yes	0	9	9
30	R:R:S312	R:R:V70	44.4108	4.85	No	Yes	0	7	9
31	R:R:M318	R:R:S312	43.5395	4.6	Yes	No	0	8	7
32	R:R:F80	R:R:M318	46.4931	11.2	Yes	Yes	0	8	8
33	R:R:F322	R:R:V70	47.0586	3.93	No	Yes	0	6	9
34	R:R:F322	R:R:M318	43.6271	6.22	No	Yes	0	6	8
35	R:R:F80	R:R:Y85	37.3202	9.28	Yes	No	0	8	9
36	R:R:I84	R:R:Y85	70.7447	3.63	No	No	0	8	9
37	R:R:E145	R:R:I84	66.9612	8.2	Yes	No	0	8	8
38	R:R:E145	R:R:V164	34.0208	4.28	Yes	No	0	8	7
39	R:R:P83	R:R:V164	26.7519	5.3	No	No	0	6	7
40	R:R:M159	R:R:P83	19.1234	10.06	No	No	0	6	6
41	R:R:M159	R:R:N161	15.3046	4.21	No	No	0	6	3
42	R:R:N161	R:R:Y86	11.4827	9.3	No	No	0	3	4
43	R:R:D315	R:R:M318	38.923	4.16	No	Yes	0	8	8
44	R:R:D315	R:R:Y85	37.0467	5.75	No	No	0	8	9
45	R:R:L139	R:R:N303	19.8273	4.12	Yes	Yes	1	8	9
46	R:R:L139	R:R:Y311	11.6148	4.69	Yes	Yes	1	8	9
47	R:R:L91	R:R:N138	16.6154	5.49	Yes	Yes	1	9	8
48	R:R:L116	R:R:W121	18.2628	4.56	No	Yes	0	6	9
49	R:R:L116	R:R:T120	17.0611	4.42	No	No	0	6	4
50	R:R:T117	R:R:T120	11.3766	6.28	No	No	0	6	4
51	R:R:L122	R:R:Y202	10.9171	3.52	No	Yes	0	5	4
52	R:R:W210	R:R:Y206	22.7041	6.75	Yes	Yes	1	6	7
53	R:R:N214	R:R:W210	24.0134	6.78	Yes	Yes	1	7	6
54	R:R:V136	R:R:W271	31.8432	4.9	Yes	Yes	1	8	8
55	R:R:N214	R:R:V136	11.8715	8.87	Yes	Yes	1	7	8
56	R:R:T217	R:R:V136	53.8788	4.76	Yes	Yes	0	7	8
57	R:R:M178	R:R:W210	12.8857	8.14	Yes	Yes	1	5	6
58	R:R:F213	R:R:M178	11.9329	3.73	No	Yes	0	5	5
59	R:R:F213	R:R:T217	23.2235	5.19	No	Yes	0	5	7
60	R:R:F213	R:R:N214	12.1804	7.25	No	Yes	0	5	7
61	R:R:L140	R:R:T217	73.3756	10.32	No	Yes	0	7	7
62	R:R:L140	R:R:V220	69.6721	2.98	No	No	0	7	5
63	R:R:L224	R:R:V220	67.8157	2.98	No	No	0	6	5
64	R:R:H147	R:R:L224	64.0936	11.57	Yes	No	0	7	6
65	R:R:F151	R:R:H147	35.7373	13.58	Yes	Yes	4	6	7
66	R:R:H147	R:R:I228	24.5881	3.98	Yes	No	0	7	9
67	R:R:E145	R:R:R163	11.1338	8.14	Yes	No	0	8	6
68	R:R:E145	R:R:T149	14.7037	4.23	Yes	No	0	8	8
69	R:R:R152	R:R:T149	11.1354	9.06	No	No	0	5	8
70	R:R:F151	R:R:V150	22.6334	3.93	Yes	No	0	6	8
71	R:R:I228	R:R:V150	22.6872	4.61	No	No	0	9	8
72	R:R:F151	R:R:Y231	11.4658	14.44	Yes	No	0	6	6
73	R:R:D129	R:R:Y202	14.3334	5.75	Yes	Yes	1	5	4
74	R:R:E293	R:R:M198	17.7388	13.53	Yes	No	0	4	3
75	R:R:L277	R:R:M198	16.6984	7.07	No	No	0	4	3
76	R:R:V150	R:R:V232	41.4694	1.6	No	No	0	8	7
77	R:R:L256	R:R:V232	30.4785	4.47	No	No	0	7	7
78	R:R:F229	R:R:L256	26.9947	6.09	Yes	No	0	6	7
79	R:R:F229	R:R:L257	11.5856	8.53	Yes	No	0	6	7
80	R:R:L277	R:R:Y292	10.3378	4.69	No	No	0	4	3
81	R:R:W121	R:R:Y202	15.5167	3.86	Yes	Yes	1	9	4
82	R:R:Y202	R:R:Y206	14.2212	4.96	Yes	Yes	1	4	7
83	R:R:D129	R:R:W210	14.5316	13.4	Yes	Yes	1	5	6
84	R:R:F267	R:R:N303	11.5995	3.62	Yes	Yes	1	9	9
85	R:R:F267	R:R:V136	11.5242	7.87	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y34	6.71	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K39	9.08	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T109	7.38	1	Yes	No	0	5	0	1
L:L:?1	R:R:T113	6.33	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	11.3	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	18.1	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	12.62	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L132	3.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W210	13.85	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E293	9.48	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	7.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	9.9	1	Yes	No	0	6	0	1
R:R:I30	R:R:Y34	3.63	1	No	Yes	6	6	2	1
R:R:I30	R:R:W121	4.7	1	No	Yes	6	9	2	2
R:R:L41	R:R:Y34	4.69	0	No	Yes	2	6	2	1
R:R:T113	R:R:Y34	4.99	1	No	Yes	5	6	1	1
R:R:W121	R:R:Y34	11.58	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	8.34	0	No	Yes	6	6	2	1
R:R:K39	R:R:P200	10.04	1	Yes	No	8	6	1	2
R:R:K39	R:R:L290	4.23	1	Yes	No	8	3	1	2
R:R:E293	R:R:K39	6.75	1	Yes	Yes	4	8	1	1
R:R:K294	R:R:V52	9.11	0	No	No	4	5	1	2
R:R:L105	R:R:Y102	3.52	0	No	Yes	6	7	2	2
R:R:L297	R:R:Y102	5.86	0	No	Yes	6	7	1	2
R:R:E301	R:R:Y102	12.35	0	No	Yes	7	7	2	2
R:R:L105	R:R:R124	9.72	0	No	Yes	6	6	2	1
R:R:N108	R:R:R124	13.26	0	No	Yes	5	6	2	1
R:R:G110	R:R:T109	5.46	0	No	No	5	5	2	1
R:R:R124	R:R:W121	13	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	13.14	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	3.86	1	Yes	Yes	9	4	2	2
R:R:Q125	R:R:R124	3.5	1	Yes	Yes	4	6	1	1
R:R:Q125	R:R:Y202	9.02	1	Yes	Yes	4	4	1	2
R:R:D129	R:R:Y202	5.75	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	10.34	1	Yes	Yes	5	7	1	2
R:R:D129	R:R:W210	13.4	1	Yes	Yes	5	6	1	1
R:R:L132	R:R:S131	4.5	0	Yes	No	7	6	1	2
R:R:L132	R:R:W271	7.97	0	Yes	Yes	7	8	1	2
R:R:E301	R:R:L132	11.93	0	No	Yes	7	7	2	1
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:W210	8.14	1	Yes	Yes	5	6	2	1
R:R:L207	R:R:S196	4.5	0	No	No	6	5	1	2
R:R:E293	R:R:M198	13.53	1	Yes	No	4	3	1	2
R:R:Y202	R:R:Y206	4.96	1	Yes	Yes	4	7	2	2
R:R:W210	R:R:Y206	6.75	1	Yes	Yes	6	7	1	2
R:R:D281	R:R:L207	4.07	0	No	No	4	6	2	1
R:R:N214	R:R:W210	6.78	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	5.62	1	Yes	Yes	6	8	1	2
R:R:A211	R:R:L278	4.73	0	No	No	4	6	2	1
R:R:N214	R:R:W271	7.91	1	Yes	Yes	7	8	2	2
R:R:E293	R:R:L290	6.63	1	Yes	No	4	3	1	2
L:L:?1	R:R:L207	2.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:L278	2.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:G274	2.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:A300	2.25	1	Yes	No	0	7	0	1
R:R:D129	R:R:G126	1.68	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	270
Number of Links	312
Number of Hubs	42
Number of Links mediated by Hubs	158
Number of Communities	6
Number of Nodes involved in Communities	56
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	145938
Length Of Smallest Path	3
Average Path Length	15.8512
Length of Longest Path	33
Minimum Path Strength	1.465
Average Path Strength	7.10538
Maximum Path Strength	18.3
Minimum Path Correlation	0.7
Average Path Correlation	0.92865
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	44.8973
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.7134
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • protein binding • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • regulation of metabolic process • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • protein-containing complex localization • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • glutamatergic synapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • dendritic shaft • plasma membrane bounded cell projection • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>9IZF_nogp_Chain_R S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R H D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Q I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	10.1016/j.jsb.2024.108164
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	10.1038/s41467-022-33121-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	10.1038/s41467-022-28417-2
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	10.1016/j.cell.2015.06.002

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