psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C190	R:R:C24	7.28	No	No	0	3	5
2	R:R:E28	R:R:F25	3.5	No	No	0	4	7
3	R:R:F25	R:R:I192	5.02	No	No	0	7	1
4	R:R:N187	R:R:Y26	3.49	No	No	4	6	4
5	R:R:I189	R:R:Y26	7.25	Yes	No	4	3	4
6	R:R:E28	R:R:F32	13.99	No	No	0	4	2
7	R:R:I30	R:R:Y34	4.84	No	Yes	0	6	6
8	R:R:F32	R:R:F33	8.57	No	No	0	2	6
9	R:R:F32	R:R:R36	6.41	No	No	0	2	3
10	R:R:F33	R:R:I189	3.77	No	Yes	0	6	3
11	R:R:F33	R:R:L201	14.61	No	No	0	6	1
12	R:R:K39	R:R:Y34	9.55	No	Yes	1	8	6
13	R:R:L41	R:R:Y34	8.21	No	Yes	0	2	6
14	R:R:W121	R:R:Y34	5.79	Yes	Yes	1	9	6
15	R:R:P200	R:R:Y34	9.74	No	Yes	0	6	6
16	L:L:?1	R:R:Y34	3.36	Yes	Yes	1	0	6
17	R:R:I192	R:R:R36	7.52	No	No	0	1	3
18	R:R:E193	R:R:R36	4.65	No	No	0	4	3
19	R:R:G38	R:R:S37	3.71	No	No	0	4	7
20	R:R:N197	R:R:S37	4.47	No	No	0	5	7
21	R:R:E293	R:R:K39	6.75	Yes	No	1	4	8
22	L:L:?1	R:R:K39	11.1	Yes	No	1	0	8
23	R:R:M53	R:R:W45	4.65	No	Yes	2	4	1
24	R:R:P111	R:R:W45	5.4	Yes	Yes	2	4	1
25	R:R:N112	R:R:W45	3.39	No	Yes	2	4	1
26	R:R:N46	R:R:T47	4.39	No	No	0	2	5
27	R:R:N46	R:R:V48	5.91	No	No	0	2	3
28	R:R:L51	R:R:L55	4.15	No	No	0	4	4
29	R:R:I57	R:R:M53	4.37	Yes	No	2	4	4
30	R:R:F107	R:R:M53	4.98	No	No	2	5	4
31	R:R:L298	R:R:L55	4.15	No	No	0	6	4
32	R:R:F107	R:R:I57	3.77	No	Yes	2	5	4
33	R:R:I63	R:R:V59	3.07	No	No	0	8	7
34	R:R:C60	R:R:Y102	4.03	No	Yes	0	6	7
35	R:R:C60	R:R:F103	5.59	No	No	0	6	6
36	R:R:A305	R:R:I63	3.25	No	No	0	7	8
37	R:R:F96	R:R:M64	7.46	No	No	5	7	6
38	R:R:L100	R:R:M64	4.24	No	No	5	4	6
39	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
40	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
41	R:R:N67	R:R:P308	8.15	Yes	No	0	9	9
42	R:R:F322	R:R:L69	10.96	No	No	0	6	7
43	R:R:I74	R:R:V70	3.07	No	No	0	7	9
44	R:R:A92	R:R:V70	3.39	No	No	0	9	9
45	R:R:A73	R:R:F322	4.16	No	No	0	7	6
46	R:R:A89	R:R:I74	3.25	No	No	0	7	7
47	R:R:I74	R:R:M318	4.37	No	No	0	7	8
48	R:R:N77	R:R:R79	3.62	Yes	Yes	3	6	6
49	R:R:F80	R:R:N77	7.25	Yes	Yes	3	8	6
50	R:R:N77	R:R:T321	4.39	Yes	No	3	6	7
51	R:R:F80	R:R:R79	10.69	Yes	Yes	3	8	6
52	R:R:R79	R:R:Y85	5.14	Yes	Yes	3	6	9
53	R:R:E317	R:R:R79	17.45	No	Yes	0	7	6
54	R:R:F80	R:R:Y85	23.73	Yes	Yes	3	8	9
55	R:R:F80	R:R:M318	8.71	Yes	No	0	8	8
56	R:R:F80	R:R:T321	3.89	Yes	No	3	8	7
57	R:R:H81	R:R:Y86	4.36	No	No	0	8	4
58	R:R:F82	R:R:P83	4.33	No	No	0	7	6
59	R:R:E145	R:R:P83	4.72	No	No	0	8	6
60	R:R:P83	R:R:V164	3.53	No	No	0	6	7
61	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
62	R:R:D315	R:R:Y85	6.9	No	Yes	0	8	9
63	R:R:N161	R:R:Y86	6.98	No	No	0	3	4
64	R:R:V164	R:R:Y86	3.79	No	No	0	7	4
65	R:R:E145	R:R:L87	3.98	No	No	0	8	8
66	R:R:M88	R:R:S312	3.07	No	No	0	8	7
67	R:R:N138	R:R:N90	13.62	No	No	0	8	9
68	R:R:I168	R:R:N90	9.91	No	No	0	8	9
69	R:R:N90	R:R:W172	12.43	No	No	0	9	9
70	R:R:D95	R:R:L91	5.43	Yes	No	0	9	9
71	R:R:L91	R:R:N138	8.24	No	No	0	9	8
72	R:R:L139	R:R:L91	4.15	No	No	0	8	9
73	R:R:D95	R:R:S135	4.42	Yes	No	6	9	9
74	R:R:D95	R:R:S304	10.31	Yes	No	6	9	9
75	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
76	R:R:F96	R:R:L100	6.09	No	No	5	7	4
77	R:R:A98	R:R:S131	3.42	No	No	0	8	6
78	R:R:A101	R:R:L127	4.73	No	No	0	5	5
79	R:R:A101	R:R:I128	3.25	No	No	0	5	6
80	R:R:M106	R:R:Y102	4.79	No	Yes	0	6	7
81	R:R:L297	R:R:Y102	10.55	No	Yes	0	6	7
82	R:R:L298	R:R:Y102	4.69	No	Yes	0	6	7
83	R:R:E301	R:R:Y102	19.08	No	Yes	0	7	7
84	R:R:F103	R:R:F107	7.5	No	No	0	6	5
85	R:R:N108	R:R:Y104	10.47	No	No	0	5	5
86	R:R:R124	R:R:Y104	3.09	Yes	No	0	6	5
87	R:R:L105	R:R:R124	7.29	No	Yes	0	6	6
88	R:R:G110	R:R:T109	5.46	No	No	0	5	5
89	L:L:?1	R:R:T109	7.38	Yes	No	0	0	5
90	R:R:G110	R:R:P111	4.06	No	Yes	0	5	4
91	R:R:N112	R:R:P111	3.26	No	Yes	2	4	4
92	R:R:N112	R:R:R115	6.03	No	No	0	4	3
93	R:R:R124	R:R:T113	5.17	Yes	No	1	6	5
94	L:L:?1	R:R:T113	11.6	Yes	No	1	0	5
95	R:R:L116	R:R:T120	4.42	No	No	0	6	4
96	R:R:L116	R:R:R124	4.86	No	Yes	0	6	6
97	R:R:T117	R:R:T120	3.14	No	No	7	6	4
98	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
99	R:R:R124	R:R:W121	6	Yes	Yes	1	6	9
100	R:R:Q125	R:R:W121	15.33	No	Yes	1	4	9
101	R:R:L201	R:R:W121	5.69	No	Yes	0	1	9
102	R:R:W121	R:R:Y202	7.72	Yes	Yes	1	9	4
103	L:L:?1	R:R:R124	5.22	Yes	Yes	1	0	6
104	R:R:Q125	R:R:Y202	7.89	No	Yes	1	4	4
105	L:L:?1	R:R:Q125	14.29	Yes	No	1	0	4
106	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
107	R:R:D129	R:R:Y202	5.75	Yes	Yes	0	5	4
108	R:R:D129	R:R:Y206	5.75	Yes	No	0	5	7
109	L:L:?1	R:R:D129	7.77	Yes	Yes	0	0	5
110	R:R:A175	R:R:T130	3.36	No	No	0	8	6
111	R:R:L132	R:R:W271	6.83	Yes	Yes	0	7	8
112	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
113	R:R:M178	R:R:T133	7.53	Yes	No	1	5	6
114	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
115	R:R:A134	R:R:W172	3.89	No	No	0	7	9
116	R:R:S135	R:R:S304	3.26	No	No	6	9	9
117	R:R:F213	R:R:V136	3.93	No	No	1	5	8
118	R:R:T217	R:R:V136	4.76	Yes	No	1	7	8
119	R:R:A137	R:R:I171	4.87	No	No	0	5	7
120	R:R:I171	R:R:N138	7.08	No	No	0	7	8
121	R:R:L139	R:R:N307	6.87	No	No	0	8	9
122	R:R:L139	R:R:Y311	5.86	No	Yes	0	8	9
123	R:R:I144	R:R:L140	5.71	No	No	0	6	7
124	R:R:L140	R:R:T217	7.37	No	Yes	0	7	7
125	R:R:I142	R:R:R146	5.01	No	No	8	8	9
126	R:R:I142	R:R:Y311	4.84	No	Yes	8	8	9
127	R:R:A143	R:R:Y225	5.34	No	No	0	8	9
128	R:R:E145	R:R:R163	5.82	No	No	0	8	6
129	R:R:R146	R:R:Y225	8.23	No	No	0	9	9
130	R:R:R146	R:R:Y311	6.17	No	Yes	8	9	9
131	R:R:F151	R:R:H147	13.58	Yes	No	0	6	7
132	R:R:H147	R:R:L224	6.43	No	No	0	7	6
133	R:R:H147	R:R:I228	7.95	No	No	0	7	9
134	R:R:I148	R:R:R163	12.53	No	No	0	5	6
135	R:R:R152	R:R:T149	3.88	No	No	0	5	8
136	R:R:F151	R:R:H227	11.31	Yes	No	0	6	5
137	R:R:F151	R:R:Y231	15.47	Yes	No	0	6	6
138	R:R:R152	R:R:T157	6.47	No	No	0	5	4
139	R:R:M153	R:R:R235	6.2	No	No	0	7	7
140	R:R:Q154	R:R:T157	11.34	No	No	0	4	4
141	R:R:H156	R:R:R158	11.28	No	No	0	4	3
142	R:R:M159	R:R:R163	14.89	No	No	0	6	6
143	R:R:R162	R:R:S160	3.95	No	No	0	5	8
144	R:R:R162	R:R:V165	3.92	No	No	0	5	1
145	R:R:I181	R:R:V177	3.07	No	No	0	5	4
146	R:R:M178	R:R:W210	4.65	Yes	Yes	1	5	6
147	R:R:F213	R:R:M178	3.73	No	Yes	1	5	5
148	R:R:I181	R:R:P182	3.39	No	Yes	0	5	6
149	R:R:I181	R:R:W186	5.87	No	No	0	5	6
150	R:R:P182	R:R:Y202	9.74	Yes	Yes	0	6	4
151	R:R:P182	R:R:Y206	18.08	Yes	No	0	6	7
152	R:R:S205	R:R:W186	3.71	No	No	0	5	6
153	R:R:W186	R:R:Y206	4.82	No	No	0	6	7
154	R:R:I189	R:R:N187	15.58	Yes	No	4	3	6
155	R:R:C188	R:R:C195	7.28	No	No	0	5	9
156	R:R:C190	R:R:I189	3.27	No	Yes	0	3	3
157	R:R:D281	R:R:S196	5.89	Yes	No	0	4	5
158	R:R:D281	R:R:N197	13.46	Yes	No	0	4	5
159	R:R:L277	R:R:M198	4.24	No	No	0	4	3
160	R:R:D281	R:R:M198	8.32	Yes	No	0	4	3
161	R:R:E293	R:R:M198	8.12	Yes	No	0	4	3
162	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
163	R:R:S203	R:R:S205	3.26	No	No	0	5	5
164	R:R:D204	R:R:V282	5.84	No	No	0	4	5
165	L:L:?1	R:R:L207	3.96	Yes	No	0	0	6
166	R:R:I212	R:R:V208	3.07	No	No	0	4	4
167	R:R:V208	R:R:V282	3.21	No	No	0	4	5
168	R:R:N214	R:R:W210	5.65	Yes	Yes	1	7	6
169	R:R:W210	R:R:W271	5.62	Yes	Yes	1	6	8
170	L:L:?1	R:R:W210	13.04	Yes	Yes	1	0	6
171	R:R:A211	R:R:L275	3.15	No	No	0	4	6
172	R:R:F213	R:R:T217	5.19	No	Yes	1	5	7
173	R:R:F267	R:R:N214	7.25	No	Yes	1	9	7
174	R:R:N214	R:R:W271	4.52	Yes	Yes	1	7	8
175	R:R:L275	R:R:N214	10.98	No	Yes	0	6	7
176	R:R:L215	R:R:L275	4.15	No	No	0	5	6
177	R:R:F218	R:R:V222	7.87	No	No	0	5	4
178	R:R:F218	R:R:F267	10.72	No	No	0	5	9
179	R:R:F218	R:R:I268	6.28	No	No	0	5	6
180	R:R:L264	R:R:V222	5.96	No	No	0	7	4
181	R:R:V260	R:R:Y225	6.31	No	No	0	8	9
182	R:R:F229	R:R:R233	5.34	Yes	No	0	6	5
183	R:R:F229	R:R:L256	6.09	Yes	No	0	6	7
184	R:R:F229	R:R:L257	6.09	Yes	No	0	6	7
185	R:R:R235	R:R:Y231	17.49	No	No	0	7	6
186	R:R:L256	R:R:V232	4.47	No	No	0	7	7
187	R:R:M253	R:R:R233	4.96	No	No	0	7	5
188	R:R:D251	R:R:M253	8.32	No	No	0	5	7
189	R:R:K258	R:R:M254	7.2	No	No	0	7	5
190	R:R:R314	R:R:S255	9.22	No	No	0	7	7
191	R:R:R314	R:R:T259	7.76	No	No	0	7	8
192	R:R:V263	R:R:Y311	5.05	No	Yes	0	8	9
193	R:R:G265	R:R:I268	5.29	No	No	0	4	6
194	R:R:F267	R:R:W271	16.04	No	Yes	1	9	8
195	R:R:I268	R:R:T272	6.08	No	No	0	6	5
196	R:R:C270	R:R:N303	9.45	No	No	0	9	9
197	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
198	R:R:N303	R:R:W271	13.56	No	Yes	0	9	8
199	R:R:P273	R:R:T272	5.25	No	No	0	9	5
200	R:R:F296	R:R:P273	4.33	Yes	No	0	5	9
201	R:R:F296	R:R:G274	6.02	Yes	No	0	5	5
202	R:R:F296	R:R:L277	9.74	Yes	No	0	5	4
203	R:R:D281	R:R:V289	8.76	Yes	No	0	4	4
204	R:R:C283	R:R:V282	3.42	No	No	0	4	5
205	R:R:C284	R:R:C287	7.28	No	No	9	4	5
206	R:R:A291	R:R:D288	3.09	No	No	0	2	1
207	R:R:A291	R:R:Y292	9.34	No	No	0	2	3
208	R:R:F296	R:R:Y292	7.22	Yes	No	0	5	3
209	R:R:E293	R:R:K294	5.4	Yes	No	1	4	4
210	L:L:?1	R:R:E293	5.69	Yes	Yes	1	0	4
211	L:L:?1	R:R:K294	10.09	Yes	No	1	0	4
212	L:L:?1	R:R:L297	9.9	Yes	No	0	0	6
213	R:R:N303	R:R:N307	5.45	No	No	0	9	9
214	R:R:I310	R:R:Y311	4.84	No	Yes	0	8	9
215	R:R:R314	R:R:Y313	5.14	No	No	0	7	5
216	R:R:F322	R:R:M318	6.22	No	No	0	6	8
217	R:R:K316	R:R:S319	3.06	No	No	0	5	8
218	R:R:K294	R:R:V52	3.04	No	No	0	4	5
219	R:R:M174	R:R:V170	3.04	No	No	0	4	3
220	R:R:M221	R:R:T217	3.01	No	Yes	0	9	7
221	R:R:F229	R:R:G230	3.01	Yes	No	0	6	2
222	R:R:M253	R:R:T252	3.01	No	No	0	7	5
223	R:R:L132	R:R:S131	3	Yes	No	0	7	6
224	R:R:N46	R:R:S49	2.98	No	No	0	2	1
225	R:R:L122	R:R:V118	2.98	No	No	0	5	2
226	R:R:L140	R:R:V220	2.98	No	No	0	7	5
227	R:R:L224	R:R:V220	2.98	No	No	0	6	5
228	R:R:L257	R:R:V261	2.98	No	No	0	7	5
229	R:R:L290	R:R:V289	2.98	No	No	0	3	4
230	L:L:?1	R:R:L278	2.97	Yes	No	0	0	6
231	R:R:D204	R:R:S196	2.94	No	No	0	4	5
232	R:R:I262	R:R:I310	2.94	No	No	0	6	8
233	R:R:I310	R:R:M306	2.92	No	No	0	8	6
234	R:R:G56	R:R:Y102	2.9	No	Yes	0	6	7
235	R:R:I142	R:R:L87	2.85	No	No	0	8	8
236	R:R:I128	R:R:L132	2.85	No	Yes	0	6	7
237	R:R:I63	R:R:N67	2.83	No	Yes	0	8	9
238	R:R:E44	R:R:T43	2.82	No	No	0	1	3
239	R:R:L123	R:R:L127	2.77	No	No	0	4	5
240	R:R:A305	R:R:F302	2.77	No	No	0	7	5
241	R:R:F97	R:R:S131	2.64	No	No	0	7	6
242	R:R:F151	R:R:V150	2.62	Yes	No	0	6	8
243	R:R:A94	R:R:W172	2.59	No	No	0	8	9
244	R:R:F97	R:R:T130	2.59	No	No	0	7	6
245	R:R:F62	R:R:I309	2.51	No	No	0	4	7
246	R:R:F103	R:R:M64	2.49	No	No	0	6	6
247	R:R:F209	R:R:M178	2.49	No	Yes	0	6	5
248	R:R:M159	R:R:R152	2.48	No	No	0	6	5
249	R:R:F96	R:R:L68	2.44	No	No	0	7	4
250	R:R:N77	R:R:R78	2.41	Yes	No	0	6	6
251	R:R:K50	R:R:W45	2.32	No	Yes	0	3	1
252	R:R:G179	R:R:P182	2.03	No	Yes	0	7	6
253	R:R:C60	R:R:G99	1.96	No	No	0	6	7
254	R:R:C284	R:R:P285	1.88	No	No	0	4	3
255	R:R:A66	R:R:P308	1.87	No	No	0	8	9
256	R:R:G54	R:R:I57	1.76	No	Yes	0	4	4
257	R:R:C188	R:R:S203	1.72	No	No	0	5	5
258	R:R:A31	R:R:S29	1.71	No	No	0	2	4
259	R:R:C287	R:R:V289	1.71	No	No	0	5	4
260	R:R:C270	R:R:I269	1.64	No	No	0	9	5
261	R:R:L299	R:R:P273	1.64	No	No	0	7	9
262	R:R:S312	R:R:V70	1.62	No	No	0	7	9
263	R:R:A141	R:R:I171	1.62	No	No	0	8	7
264	R:R:S183	R:R:V184	1.62	No	No	0	6	5
265	R:R:A92	R:R:M71	1.61	No	No	0	9	7
266	R:R:A93	R:R:M71	1.61	No	No	0	6	7
267	R:R:A266	R:R:M306	1.61	No	No	0	6	6
268	R:R:V48	R:R:V52	1.6	No	No	0	3	5
269	R:R:V72	R:R:V76	1.6	No	No	0	5	5
270	R:R:S119	R:R:T117	1.6	No	No	7	1	6
271	R:R:S119	R:R:T120	1.6	No	No	7	1	4
272	R:R:V150	R:R:V232	1.6	No	No	0	8	7
273	R:R:V164	R:R:V165	1.6	No	No	0	7	1
274	R:R:V165	R:R:V169	1.6	No	No	0	1	4
275	R:R:V166	R:R:V170	1.6	No	No	0	3	3
276	R:R:V169	R:R:V170	1.6	No	No	0	4	3
277	R:R:V216	R:R:V220	1.6	No	No	0	4	5
278	R:R:V219	R:R:V223	1.6	No	No	0	3	4
279	R:R:T58	R:R:V59	1.59	No	No	0	5	7
280	R:R:T173	R:R:V177	1.59	No	No	0	3	4
281	R:R:T236	R:R:V232	1.59	No	No	0	5	7
282	R:R:C284	R:R:L280	1.59	No	No	9	4	5
283	R:R:C287	R:R:L280	1.59	No	No	9	5	5
284	R:R:A211	R:R:L279	1.58	No	No	0	4	6
285	R:R:A31	R:R:N35	1.56	No	No	0	2	7
286	R:R:C190	R:R:D191	1.56	No	No	0	3	4
287	R:R:M237	R:R:S240	1.53	No	No	0	5	4
288	R:R:I176	R:R:T130	1.52	No	No	0	3	6
289	R:R:L69	R:R:V72	1.49	No	No	0	7	5
290	R:R:L87	R:R:V167	1.49	No	No	0	8	6
291	R:R:L280	R:R:V276	1.49	No	No	0	5	6
292	R:R:I57	R:R:I61	1.47	Yes	No	0	4	4
293	R:R:P111	R:R:R114	1.44	Yes	No	0	4	6
294	R:R:A305	R:R:F62	1.39	No	No	0	7	4
295	R:R:D251	R:R:M254	1.39	No	No	0	5	5
296	R:R:D191	R:R:N194	1.35	No	No	0	4	3
297	R:R:E317	R:R:K316	1.35	No	No	0	7	5
298	R:R:R241	R:R:S240	1.32	No	No	0	4	4
299	R:R:E28	R:R:N27	1.31	No	No	0	4	8
300	R:R:F295	R:R:V52	1.31	No	No	0	4	5
301	R:R:R114	R:R:T43	1.29	No	No	0	6	3
302	R:R:H156	R:R:L155	1.29	No	No	0	4	8
303	R:R:I262	R:R:Y313	1.21	No	No	0	6	5
304	R:R:I309	R:R:Y313	1.21	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	6.915	6	1	6
2	R:R:W45	3.94	4	2	1
3	R:R:I57	2.8425	4	2	4
4	R:R:N67	5.6	4	0	9
5	R:R:N77	4.4175	4	3	6
6	R:R:R79	9.225	4	3	6
7	R:R:F80	10.854	5	3	8
8	R:R:Y85	9.85	4	3	9
9	R:R:D95	6.994	5	6	9
10	R:R:Y102	7.67333	6	0	7
11	R:R:P111	3.54	4	2	4
12	R:R:W121	7.325	6	1	9
13	R:R:R124	5.27167	6	1	6
14	R:R:D129	6.075	4	0	5
15	R:R:L132	4.8275	4	0	7
16	R:R:F151	10.745	4	0	6
17	R:R:M178	4.6	4	1	5
18	R:R:P182	8.31	4	0	6
19	R:R:I189	7.4675	4	4	3
20	R:R:Y202	7.02	5	1	4
21	R:R:W210	7.004	5	1	6
22	R:R:N214	7.1	4	1	7
23	R:R:T217	5.0825	4	1	7
24	R:R:F229	5.1325	4	0	6
25	R:R:W271	8.41	6	1	8
26	R:R:D281	9.1075	4	0	4
27	R:R:E293	6.49	4	1	4
28	R:R:F296	6.8275	4	0	5
29	R:R:Y311	5.352	5	8	9
30	L:L:?1	8.18231	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C190	R:R:I189	12.5894	3.27	No	Yes	0	3	3
2	R:R:F33	R:R:I189	21.9519	3.77	No	Yes	0	6	3
3	R:R:F32	R:R:F33	21.9519	8.57	No	No	0	2	6
4	R:R:F33	R:R:L201	46.5726	14.61	No	No	0	6	1
5	R:R:L201	R:R:W121	49.4104	5.69	No	Yes	0	1	9
6	R:R:W121	R:R:Y34	20.4269	5.79	Yes	Yes	1	9	6
7	L:L:?1	R:R:Y34	21.6964	3.36	Yes	Yes	1	0	6
8	L:L:?1	R:R:R124	25.4972	5.22	Yes	Yes	1	0	6
9	R:R:R124	R:R:W121	18.8507	6	Yes	Yes	1	6	9
10	L:L:?1	R:R:Q125	25.167	14.29	Yes	No	1	0	4
11	R:R:Q125	R:R:W121	17.8131	15.33	No	Yes	1	4	9
12	R:R:E293	R:R:M198	33.0713	8.12	Yes	No	0	4	3
13	R:R:D281	R:R:M198	23.1153	8.32	Yes	No	0	4	3
14	L:L:?1	R:R:E293	30.8702	5.69	Yes	Yes	1	0	4
15	L:L:?1	R:R:T109	15.5255	7.38	Yes	No	0	0	5
16	R:R:G110	R:R:T109	14.4486	5.46	No	No	0	5	5
17	R:R:G110	R:R:P111	13.2655	4.06	No	Yes	0	5	4
18	L:L:?1	R:R:L297	13.8039	9.9	Yes	No	0	0	6
19	R:R:L297	R:R:Y102	12.7152	10.55	No	Yes	0	6	7
20	R:R:C60	R:R:Y102	14.1459	4.03	No	Yes	0	6	7
21	R:R:C60	R:R:F103	11.8112	5.59	No	No	0	6	6
22	L:L:?1	R:R:W210	100	13.04	Yes	Yes	1	0	6
23	R:R:W210	R:R:W271	86.99	5.62	Yes	Yes	1	6	8
24	R:R:N303	R:R:W271	93.1137	13.56	No	Yes	0	9	8
25	R:R:N303	R:R:N307	91.5219	5.45	No	No	0	9	9
26	R:R:D95	R:R:N307	49.7484	8.08	Yes	No	0	9	9
27	R:R:D95	R:R:N67	43.4321	6.73	Yes	Yes	0	9	9
28	R:R:A92	R:R:N67	32.8708	4.69	No	Yes	0	9	9
29	R:R:A92	R:R:V70	29.1683	3.39	No	No	0	9	9
30	R:R:I74	R:R:V70	25.395	3.07	No	No	0	7	9
31	R:R:I74	R:R:M318	22.8323	4.37	No	No	0	7	8
32	R:R:F80	R:R:M318	15.1128	8.71	Yes	No	0	8	8
33	R:R:L139	R:R:N307	51.0887	6.87	No	No	0	8	9
34	R:R:L139	R:R:Y311	47.0993	5.86	No	Yes	0	8	9
35	R:R:I142	R:R:Y311	31.1532	4.84	No	Yes	8	8	9
36	R:R:I142	R:R:L87	30.2924	2.85	No	No	0	8	8
37	R:R:E145	R:R:L87	27.7651	3.98	No	No	0	8	8
38	R:R:E145	R:R:P83	17.8602	4.72	No	No	0	8	6
39	R:R:P83	R:R:V164	15.215	3.53	No	No	0	6	7
40	R:R:D95	R:R:L91	15.7731	5.43	Yes	No	0	9	9
41	R:R:L91	R:R:N138	19.629	8.24	No	No	0	9	8
42	R:R:L139	R:R:L91	15.8517	4.15	No	No	0	8	9
43	R:R:N138	R:R:N90	10.9818	13.62	No	No	0	8	9
44	R:R:L132	R:R:W271	21.8143	6.83	Yes	Yes	0	7	8
45	R:R:D129	R:R:Y206	14.1459	5.75	Yes	No	0	5	7
46	R:R:P182	R:R:Y202	11.1666	9.74	Yes	Yes	0	6	4
47	R:R:M178	R:R:W210	38.8138	4.65	Yes	Yes	1	5	6
48	R:R:F213	R:R:M178	36.7227	3.73	No	Yes	1	5	5
49	R:R:F213	R:R:T217	34.3644	5.19	No	Yes	1	5	7
50	R:R:L140	R:R:T217	32.1948	7.37	No	Yes	0	7	7
51	R:R:L140	R:R:V220	29.8837	2.98	No	No	0	7	5
52	R:R:L224	R:R:V220	27.5411	2.98	No	No	0	6	5
53	R:R:H147	R:R:L224	26.358	6.43	No	No	0	7	6
54	R:R:F151	R:R:H147	24.0311	13.58	Yes	No	0	6	7
55	R:R:L277	R:R:M198	10.7853	4.24	No	No	0	4	3
56	R:R:F267	R:R:W271	11.7483	16.04	No	Yes	1	9	8
57	R:R:F218	R:R:F267	15.0263	10.72	No	No	0	5	9
58	R:R:F151	R:R:V150	17.9899	2.62	Yes	No	0	6	8
59	R:R:V150	R:R:V232	16.74	1.6	No	No	0	8	7
60	R:R:L256	R:R:V232	14.3071	4.47	No	No	0	7	7
61	R:R:F229	R:R:L256	13.1122	6.09	Yes	No	0	6	7
62	R:R:I310	R:R:Y311	11.0958	4.84	No	Yes	0	8	9
63	L:L:?1	R:R:D129	22.0108	7.77	Yes	Yes	0	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I30	R:R:Y34	4.84	0	No	Yes	6	6	2	1
R:R:K39	R:R:Y34	9.55	1	No	Yes	8	6	1	1
R:R:L41	R:R:Y34	8.21	0	No	Yes	2	6	2	1
R:R:W121	R:R:Y34	5.79	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	9.74	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	3.36	1	Yes	Yes	0	6	0	1
R:R:E293	R:R:K39	6.75	1	Yes	No	4	8	1	1
L:L:?1	R:R:K39	11.1	1	Yes	No	0	8	0	1
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:R124	R:R:Y104	3.09	1	Yes	No	6	5	1	2
R:R:L105	R:R:R124	7.29	0	No	Yes	6	6	2	1
R:R:G110	R:R:T109	5.46	0	No	No	5	5	2	1
L:L:?1	R:R:T109	7.38	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	5.17	1	Yes	No	6	5	1	1
L:L:?1	R:R:T113	11.6	1	Yes	No	0	5	0	1
R:R:L116	R:R:R124	4.86	0	No	Yes	6	6	2	1
R:R:R124	R:R:W121	6	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	No	Yes	4	9	1	2
R:R:W121	R:R:Y202	7.72	1	Yes	Yes	9	4	2	2
L:L:?1	R:R:R124	5.22	1	Yes	Yes	0	6	0	1
R:R:Q125	R:R:Y202	7.89	1	No	Yes	4	4	1	2
L:L:?1	R:R:Q125	14.29	1	Yes	No	0	4	0	1
R:R:D129	R:R:G126	5.03	0	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	5.75	0	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	5.75	0	Yes	No	5	7	1	2
L:L:?1	R:R:D129	7.77	1	Yes	Yes	0	5	0	1
R:R:M178	R:R:T133	7.53	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:W210	4.65	1	Yes	Yes	5	6	2	1
R:R:E293	R:R:M198	8.12	1	Yes	No	4	3	1	2
L:L:?1	R:R:L207	3.96	1	Yes	No	0	6	0	1
R:R:N214	R:R:W210	5.65	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	5.62	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	13.04	1	Yes	Yes	0	6	0	1
R:R:N214	R:R:W271	4.52	1	Yes	Yes	7	8	2	2
R:R:E293	R:R:K294	5.4	1	Yes	No	4	4	1	1
L:L:?1	R:R:E293	5.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	10.09	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	9.9	1	Yes	No	0	6	0	1
R:R:K294	R:R:V52	3.04	1	No	No	4	5	1	2
L:L:?1	R:R:L278	2.97	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TD1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	279
Number of Links	304
Number of Hubs	30
Number of Links mediated by Hubs	122
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	53747
Length Of Smallest Path	3
Average Path Length	12.8053
Length of Longest Path	32
Minimum Path Strength	1.21
Average Path Strength	6.76593
Maximum Path Strength	16.48
Minimum Path Correlation	0.7
Average Path Correlation	0.931625
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	55.925
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.5883
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • ion binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • small molecule binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • protein binding • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • nerve development • cranial nerve development • anatomical structure development • optic nerve development • nervous system development • system development • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • biological regulation • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • animal organ development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • protein-containing complex localization • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to lipid • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to lipid • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • glutamatergic synapse • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • dendritic shaft • plasma membrane bounded cell projection • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • protein localization • protein localization to postsynaptic specialization membrane • cellular localization • protein localization to postsynaptic membrane • protein localization to cell periphery • protein localization to synapse • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • cellular macromolecule localization • macromolecule localization • protein localization to postsynapse • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • response to forskolin • midbody • cell cortex • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • nucleus • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7TD1_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S R R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	10.1016/j.jsb.2024.108164
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	10.1038/s42003-024-07152-y
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	10.1016/j.jsb.2024.108164
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	10.1038/s41467-022-33121-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	10.1038/s41467-022-33121-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	10.1038/s41467-022-28417-2
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	10.1016/j.cell.2015.06.002
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	10.1016/j.cell.2015.06.002

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