psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F25	R:R:Q23	3.51	No	No	0	7	3
2	R:R:C190	R:R:C24	7.28	No	No	0	3	5
3	R:R:F25	R:R:I192	7.54	No	No	0	7	1
4	R:R:N187	R:R:Y26	4.65	No	No	2	6	4
5	R:R:I189	R:R:Y26	21.76	Yes	No	2	3	4
6	R:R:E28	R:R:F32	7	No	No	0	4	2
7	R:R:I30	R:R:Y34	4.84	No	Yes	1	6	6
8	R:R:I30	R:R:W121	5.87	No	Yes	1	6	9
9	R:R:F32	R:R:F33	4.29	No	No	0	2	6
10	R:R:F32	R:R:R36	5.34	No	No	0	2	3
11	R:R:F33	R:R:L201	19.49	No	No	0	6	1
12	R:R:K39	R:R:Y34	11.94	Yes	Yes	1	8	6
13	R:R:L41	R:R:Y34	8.21	No	Yes	0	2	6
14	R:R:T113	R:R:Y34	3.75	No	Yes	1	5	6
15	R:R:W121	R:R:Y34	3.86	Yes	Yes	1	9	6
16	R:R:P200	R:R:Y34	12.52	No	Yes	1	6	6
17	L:L:?1	R:R:Y34	7.55	Yes	Yes	1	0	6
18	R:R:I192	R:R:R36	7.52	No	No	0	1	3
19	R:R:G38	R:R:S37	3.71	No	No	0	4	7
20	R:R:K39	R:R:P200	5.02	Yes	No	1	8	6
21	R:R:E293	R:R:K39	9.45	Yes	Yes	1	4	8
22	L:L:?1	R:R:K39	10.09	Yes	Yes	1	0	8
23	R:R:S49	R:R:W45	3.71	No	No	0	1	1
24	R:R:M53	R:R:W45	4.65	No	No	0	4	1
25	R:R:P111	R:R:W45	12.16	No	No	0	4	1
26	R:R:N46	R:R:T47	7.31	No	No	0	2	5
27	R:R:N46	R:R:V48	5.91	No	No	0	2	3
28	R:R:L51	R:R:L55	4.15	No	No	0	4	4
29	R:R:F107	R:R:M53	6.22	No	No	0	5	4
30	R:R:G54	R:R:I57	3.53	No	No	0	4	4
31	R:R:L298	R:R:L55	4.15	No	No	0	6	4
32	R:R:F103	R:R:I57	3.77	No	No	0	6	4
33	R:R:I63	R:R:V59	3.07	Yes	No	0	8	7
34	R:R:L298	R:R:V59	4.47	No	No	0	6	7
35	R:R:C60	R:R:Y102	5.38	No	Yes	0	6	7
36	R:R:C60	R:R:F103	4.19	No	No	0	6	6
37	R:R:I63	R:R:N67	4.25	Yes	Yes	0	8	9
38	R:R:G99	R:R:I63	5.29	No	Yes	0	7	8
39	R:R:I63	R:R:S304	4.64	Yes	No	0	8	9
40	R:R:A305	R:R:I63	3.25	No	Yes	0	7	8
41	R:R:F96	R:R:M64	6.22	Yes	No	3	7	6
42	R:R:L100	R:R:M64	4.24	No	No	3	4	6
43	R:R:A66	R:R:P308	3.74	No	No	0	8	9
44	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
45	R:R:N67	R:R:P308	8.15	Yes	No	0	9	9
46	R:R:F96	R:R:L68	8.53	Yes	No	0	7	4
47	R:R:F322	R:R:L69	18.27	No	No	0	6	7
48	R:R:I74	R:R:V70	3.07	Yes	No	0	7	9
49	R:R:A92	R:R:V70	3.39	No	No	0	9	9
50	R:R:M71	R:R:Y75	3.59	No	No	0	7	3
51	R:R:A93	R:R:M71	3.22	No	No	0	6	7
52	R:R:A73	R:R:T321	3.36	No	No	0	7	7
53	R:R:A73	R:R:F322	4.16	No	No	0	7	6
54	R:R:I74	R:R:Y75	3.63	Yes	No	0	7	3
55	R:R:A89	R:R:I74	3.25	No	Yes	0	7	7
56	R:R:N77	R:R:V76	4.43	No	No	0	6	5
57	R:R:N77	R:R:T321	16.08	No	No	0	6	7
58	R:R:F80	R:R:Y85	22.69	Yes	Yes	4	8	9
59	R:R:F80	R:R:M318	12.44	Yes	Yes	4	8	8
60	R:R:F80	R:R:T321	3.89	Yes	No	0	8	7
61	R:R:H81	R:R:Y86	11.98	No	No	0	8	4
62	R:R:E145	R:R:P83	4.72	No	Yes	0	8	6
63	R:R:M159	R:R:P83	8.39	No	Yes	0	6	6
64	R:R:P83	R:R:V164	3.53	Yes	Yes	0	6	7
65	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
66	R:R:E145	R:R:I84	8.2	No	No	0	8	8
67	R:R:M88	R:R:Y85	4.79	No	Yes	0	8	9
68	R:R:D315	R:R:Y85	5.75	No	Yes	0	8	9
69	R:R:M318	R:R:Y85	3.59	Yes	Yes	4	8	9
70	R:R:N161	R:R:Y86	4.65	No	No	0	3	4
71	R:R:V164	R:R:Y86	7.57	Yes	No	0	7	4
72	R:R:E145	R:R:L87	9.28	No	No	0	8	8
73	R:R:M88	R:R:S312	3.07	No	No	0	8	7
74	R:R:N138	R:R:N90	14.98	No	No	0	8	9
75	R:R:I168	R:R:N90	9.91	No	No	0	8	9
76	R:R:N90	R:R:W172	10.17	No	No	0	9	9
77	R:R:D95	R:R:L91	8.14	Yes	Yes	0	9	9
78	R:R:L91	R:R:N138	8.24	Yes	No	0	9	8
79	R:R:L139	R:R:L91	4.15	No	Yes	0	8	9
80	R:R:I142	R:R:L91	4.28	No	Yes	0	8	9
81	R:R:D95	R:R:S135	5.89	Yes	No	0	9	9
82	R:R:D95	R:R:S304	7.36	Yes	No	0	9	9
83	R:R:D95	R:R:N307	12.12	Yes	No	0	9	9
84	R:R:F96	R:R:L100	7.31	Yes	No	3	7	4
85	R:R:F97	R:R:S131	3.96	No	Yes	0	7	6
86	R:R:A98	R:R:S131	3.42	No	Yes	0	8	6
87	R:R:A101	R:R:S131	3.42	No	Yes	0	5	6
88	R:R:L105	R:R:Y102	3.52	Yes	Yes	0	6	7
89	R:R:L297	R:R:Y102	10.55	No	Yes	0	6	7
90	R:R:L298	R:R:Y102	5.86	No	Yes	0	6	7
91	R:R:E301	R:R:Y102	21.32	No	Yes	0	7	7
92	R:R:F103	R:R:F107	9.65	No	No	0	6	5
93	R:R:N108	R:R:Y104	8.14	No	No	0	5	5
94	R:R:R124	R:R:Y104	3.09	Yes	No	0	6	5
95	R:R:L105	R:R:M106	4.24	Yes	No	0	6	6
96	R:R:L105	R:R:R124	7.29	Yes	Yes	0	6	6
97	R:R:I128	R:R:L105	4.28	No	Yes	0	6	6
98	R:R:R124	R:R:T109	5.17	Yes	No	1	6	5
99	L:L:?1	R:R:T109	8.44	Yes	No	1	0	5
100	R:R:G110	R:R:P111	4.06	No	No	0	5	4
101	R:R:N112	R:R:P111	3.26	No	No	0	4	4
102	R:R:R124	R:R:T113	3.88	Yes	No	1	6	5
103	L:L:?1	R:R:T113	5.27	Yes	No	1	0	5
104	R:R:L116	R:R:T120	5.9	No	No	0	6	4
105	R:R:L116	R:R:R124	6.07	No	Yes	0	6	6
106	R:R:S119	R:R:T117	4.8	No	No	0	1	6
107	R:R:T117	R:R:T120	6.28	No	No	0	6	4
108	R:R:L122	R:R:W121	3.42	No	Yes	0	5	9
109	R:R:Q125	R:R:W121	14.24	Yes	Yes	1	4	9
110	R:R:L201	R:R:W121	11.39	No	Yes	0	1	9
111	R:R:W121	R:R:Y202	7.72	Yes	Yes	1	9	4
112	R:R:L123	R:R:L127	4.15	No	No	0	4	5
113	L:L:?1	R:R:R124	3.48	Yes	Yes	1	0	6
114	R:R:D129	R:R:Q125	5.22	Yes	Yes	1	5	4
115	R:R:Q125	R:R:Y202	11.27	Yes	Yes	1	4	4
116	L:L:?1	R:R:Q125	17.14	Yes	Yes	1	0	4
117	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
118	L:L:?1	R:R:I128	5.11	Yes	No	0	0	6
119	R:R:D129	R:R:Y202	8.05	Yes	Yes	1	5	4
120	R:R:D129	R:R:Y206	6.9	Yes	No	1	5	7
121	L:L:?1	R:R:D129	6.8	Yes	Yes	1	0	5
122	R:R:L132	R:R:W271	6.83	Yes	Yes	0	7	8
123	R:R:E301	R:R:L132	6.63	No	Yes	0	7	7
124	L:L:?1	R:R:L132	3.96	Yes	Yes	0	0	7
125	R:R:M178	R:R:T133	9.03	No	No	1	5	6
126	R:R:T133	R:R:W210	7.28	No	Yes	1	6	6
127	R:R:A134	R:R:W172	3.89	No	No	0	7	9
128	R:R:F213	R:R:V136	5.24	Yes	Yes	1	5	8
129	R:R:N214	R:R:V136	4.43	Yes	Yes	1	7	8
130	R:R:T217	R:R:V136	4.76	Yes	Yes	1	7	8
131	R:R:F267	R:R:V136	5.24	Yes	Yes	1	9	8
132	R:R:V136	R:R:W271	3.68	Yes	Yes	1	8	8
133	R:R:A137	R:R:I171	4.87	No	No	0	5	7
134	R:R:I171	R:R:N138	5.66	No	No	0	7	8
135	R:R:L139	R:R:N307	8.24	No	No	0	8	9
136	R:R:L139	R:R:Y311	5.86	No	Yes	0	8	9
137	R:R:I144	R:R:L140	4.28	No	No	0	6	7
138	R:R:L140	R:R:T217	7.37	No	Yes	0	7	7
139	R:R:A141	R:R:I171	3.25	No	No	0	8	7
140	R:R:I142	R:R:R146	5.01	No	No	5	8	9
141	R:R:I142	R:R:Y311	7.25	No	Yes	5	8	9
142	R:R:A143	R:R:Y225	5.34	No	Yes	0	8	9
143	R:R:R146	R:R:Y225	8.23	No	Yes	0	9	9
144	R:R:R146	R:R:Y311	7.2	No	Yes	5	9	9
145	R:R:F151	R:R:H147	6.79	Yes	Yes	6	6	7
146	R:R:H147	R:R:L224	7.71	Yes	No	0	7	6
147	R:R:H147	R:R:H227	8.36	Yes	No	6	7	5
148	R:R:H147	R:R:I228	7.95	Yes	No	0	7	9
149	R:R:I148	R:R:R163	3.76	No	No	0	5	6
150	R:R:R152	R:R:T149	11.64	No	No	0	5	8
151	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
152	R:R:I228	R:R:V150	9.22	No	No	0	9	8
153	R:R:F151	R:R:H227	12.44	Yes	No	6	6	5
154	R:R:F151	R:R:Y231	19.6	Yes	No	0	6	6
155	R:R:R152	R:R:T157	12.94	No	No	0	5	4
156	R:R:M159	R:R:R152	8.69	No	No	0	6	5
157	R:R:M153	R:R:R235	6.2	No	No	0	7	7
158	R:R:Q154	R:R:T157	11.34	No	No	7	4	4
159	R:R:Q154	R:R:R158	4.67	No	No	7	4	3
160	R:R:H156	R:R:L155	3.86	No	No	0	4	8
161	R:R:R158	R:R:T157	6.47	No	No	7	3	4
162	R:R:V164	R:R:V165	3.21	Yes	No	0	7	1
163	R:R:I168	R:R:V164	3.07	No	Yes	0	8	7
164	R:R:I181	R:R:V177	3.07	No	No	0	5	4
165	R:R:M178	R:R:W210	6.98	No	Yes	1	5	6
166	R:R:F213	R:R:M178	8.71	Yes	No	1	5	5
167	R:R:I181	R:R:P182	3.39	No	No	0	5	6
168	R:R:I181	R:R:W186	5.87	No	No	0	5	6
169	R:R:P182	R:R:Y202	9.74	No	Yes	1	6	4
170	R:R:P182	R:R:Y206	16.69	No	No	1	6	7
171	R:R:G185	R:R:V184	3.68	No	No	0	5	5
172	R:R:S205	R:R:W186	9.88	No	No	0	5	6
173	R:R:F209	R:R:W186	5.01	No	No	0	6	6
174	R:R:I189	R:R:N187	14.16	Yes	No	2	3	6
175	R:R:C188	R:R:C195	7.28	No	No	0	5	9
176	R:R:C188	R:R:S203	3.44	No	No	0	5	5
177	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
178	R:R:D281	R:R:N197	13.46	Yes	No	0	4	5
179	R:R:L277	R:R:M198	5.65	Yes	Yes	1	4	3
180	R:R:D281	R:R:M198	5.54	Yes	Yes	0	4	3
181	R:R:E293	R:R:M198	9.47	Yes	Yes	1	4	3
182	L:L:?1	R:R:M198	5.06	Yes	Yes	1	0	3
183	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
184	R:R:Y202	R:R:Y206	3.97	Yes	No	1	4	7
185	R:R:S203	R:R:S205	4.89	No	No	0	5	5
186	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
187	R:R:L207	R:R:L278	5.54	No	No	0	6	6
188	R:R:L207	R:R:V282	4.47	No	Yes	0	6	5
189	R:R:I212	R:R:V208	3.07	No	No	0	4	4
190	R:R:V208	R:R:V282	4.81	No	Yes	0	4	5
191	R:R:N214	R:R:W210	6.78	Yes	Yes	1	7	6
192	R:R:W210	R:R:W271	6.56	Yes	Yes	1	6	8
193	L:L:?1	R:R:W210	11.41	Yes	Yes	1	0	6
194	R:R:F213	R:R:T217	6.49	Yes	Yes	1	5	7
195	R:R:F267	R:R:N214	6.04	Yes	Yes	1	9	7
196	R:R:N214	R:R:W271	14.69	Yes	Yes	1	7	8
197	R:R:L275	R:R:N214	12.36	No	Yes	0	6	7
198	R:R:F218	R:R:V222	6.55	No	No	0	5	4
199	R:R:F218	R:R:F267	12.86	No	Yes	0	5	9
200	R:R:F218	R:R:I268	10.05	No	Yes	0	5	6
201	R:R:F267	R:R:M221	3.73	Yes	No	0	9	9
202	R:R:L264	R:R:V222	7.45	No	No	0	7	4
203	R:R:V260	R:R:Y225	7.57	No	Yes	0	8	9
204	R:R:V263	R:R:Y225	3.79	No	Yes	0	8	9
205	R:R:F229	R:R:R233	3.21	Yes	No	8	6	5
206	R:R:F229	R:R:M253	4.98	Yes	Yes	8	6	7
207	R:R:F229	R:R:L256	7.31	Yes	No	0	6	7
208	R:R:F229	R:R:L257	7.31	Yes	No	0	6	7
209	R:R:R235	R:R:Y231	17.49	No	No	0	7	6
210	R:R:L256	R:R:V232	4.47	No	No	0	7	7
211	R:R:M253	R:R:R233	6.2	Yes	No	8	7	5
212	R:R:T236	R:R:T252	4.71	No	No	0	5	5
213	R:R:D251	R:R:M253	6.93	No	Yes	0	5	7
214	R:R:D251	R:R:M254	8.32	No	No	0	5	5
215	R:R:R314	R:R:S255	6.59	No	No	0	7	7
216	R:R:R314	R:R:T259	5.17	No	No	0	7	8
217	R:R:V263	R:R:Y311	5.05	No	Yes	0	8	9
218	R:R:F267	R:R:W271	15.03	Yes	Yes	1	9	8
219	R:R:F267	R:R:N303	3.62	Yes	Yes	1	9	9
220	R:R:I268	R:R:T272	6.08	Yes	No	0	6	5
221	R:R:C270	R:R:N303	9.45	No	Yes	0	9	9
222	R:R:A300	R:R:W271	5.19	No	Yes	0	7	8
223	R:R:N303	R:R:W271	10.17	Yes	Yes	1	9	8
224	R:R:P273	R:R:T272	5.25	No	No	0	9	5
225	R:R:F296	R:R:P273	8.67	Yes	No	0	5	9
226	R:R:F296	R:R:G274	4.52	Yes	No	0	5	5
227	L:L:?1	R:R:G274	3.67	Yes	No	0	0	5
228	R:R:L277	R:R:V289	4.47	Yes	No	0	4	4
229	R:R:L277	R:R:Y292	3.52	Yes	No	1	4	3
230	R:R:F296	R:R:L277	10.96	Yes	Yes	1	5	4
231	L:L:?1	R:R:L278	4.95	Yes	No	0	0	6
232	R:R:D281	R:R:V289	7.3	Yes	No	0	4	4
233	R:R:C283	R:R:V282	3.42	No	Yes	0	4	5
234	R:R:C284	R:R:P285	3.77	No	No	0	4	3
235	R:R:C284	R:R:C287	7.28	No	No	0	4	5
236	R:R:A291	R:R:Y292	8.01	No	No	0	2	3
237	R:R:F296	R:R:Y292	4.13	Yes	No	1	5	3
238	R:R:E293	R:R:K294	5.4	Yes	No	1	4	4
239	L:L:?1	R:R:E293	5.69	Yes	Yes	1	0	4
240	L:L:?1	R:R:K294	9.08	Yes	No	1	0	4
241	L:L:?1	R:R:L297	12.87	Yes	No	0	0	6
242	R:R:F302	R:R:M306	11.2	No	No	0	5	6
243	R:R:N303	R:R:N307	6.81	Yes	No	0	9	9
244	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
245	R:R:M318	R:R:S312	3.07	Yes	No	0	8	7
246	R:R:F322	R:R:M318	6.22	No	Yes	0	6	8
247	R:R:I57	R:R:T58	3.04	No	No	0	4	5
248	R:R:I176	R:R:T130	3.04	No	No	0	3	6
249	R:R:F229	R:R:G230	3.01	Yes	No	0	6	2
250	R:R:M253	R:R:T252	3.01	Yes	No	0	7	5
251	R:R:L132	R:R:S131	3	Yes	Yes	0	7	6
252	R:R:N46	R:R:S49	2.98	No	No	0	2	1
253	R:R:L140	R:R:V220	2.98	No	No	0	7	5
254	R:R:L224	R:R:V220	2.98	No	No	0	6	5
255	R:R:L280	R:R:V276	2.98	No	No	0	5	6
256	R:R:I262	R:R:I310	2.94	No	No	0	6	8
257	R:R:I268	R:R:I269	2.94	Yes	No	0	6	5
258	R:R:I74	R:R:M318	2.92	Yes	Yes	0	7	8
259	R:R:G56	R:R:Y102	2.9	No	Yes	0	6	7
260	R:R:F82	R:R:P83	2.89	No	Yes	0	7	6
261	R:R:I189	R:R:L201	2.85	Yes	No	0	3	1
262	R:R:A305	R:R:F302	2.77	No	No	0	7	5
263	R:R:H40	R:R:T43	2.74	No	No	0	2	3
264	R:R:E293	R:R:L290	2.65	Yes	No	0	4	3
265	R:R:E193	R:R:N194	2.63	No	No	0	4	3
266	R:R:A94	R:R:W172	2.59	No	No	0	8	9
267	R:R:F97	R:R:T130	2.59	No	No	0	7	6
268	R:R:V118	R:R:Y26	2.52	No	No	0	2	4
269	R:R:F213	R:R:M174	2.49	Yes	No	0	5	4
270	R:R:F97	R:R:L127	2.44	No	No	0	7	5
271	R:R:L41	R:R:R114	2.43	No	No	0	2	6
272	R:R:F96	R:R:N67	2.42	Yes	Yes	0	7	9
273	R:R:I262	R:R:Y313	2.42	No	No	0	6	5
274	R:R:D315	R:R:R314	2.38	No	No	0	8	7
275	R:R:E317	R:R:F80	2.33	No	Yes	0	7	8
276	R:R:F80	R:R:R79	2.14	Yes	No	0	8	6
277	R:R:A42	R:R:G110	1.95	No	No	0	4	5
278	R:R:G126	R:R:S183	1.86	No	No	0	6	6
279	R:R:G179	R:R:T130	1.82	No	No	0	7	6
280	R:R:A134	R:R:A175	1.79	No	No	0	7	8
281	R:R:G265	R:R:I268	1.76	No	Yes	0	4	6
282	R:R:A31	R:R:S29	1.71	No	No	0	2	4
283	R:R:G38	R:R:L290	1.71	No	No	0	4	3
284	R:R:C287	R:R:V289	1.71	No	No	0	5	4
285	R:R:C24	R:R:I189	1.64	No	Yes	0	5	3
286	R:R:L299	R:R:P273	1.64	No	No	0	7	9
287	R:R:A266	R:R:M306	1.61	No	No	0	6	6
288	R:R:V48	R:R:V52	1.6	No	No	0	3	5
289	R:R:V72	R:R:V76	1.6	No	No	0	5	5
290	R:R:V150	R:R:V232	1.6	No	No	0	8	7
291	R:R:V169	R:R:V170	1.6	No	No	0	4	3
292	R:R:V219	R:R:V220	1.6	No	No	0	3	5
293	R:R:T217	R:R:V216	1.59	Yes	No	0	7	4
294	R:R:T272	R:R:V276	1.59	No	No	0	5	6
295	R:R:A211	R:R:L275	1.58	No	No	0	4	6
296	R:R:A211	R:R:L279	1.58	No	No	0	4	6
297	R:R:C190	R:R:D191	1.56	No	No	0	3	4
298	R:R:I262	R:R:V261	1.54	No	No	0	6	5
299	R:R:A291	R:R:D288	1.54	No	No	0	2	1
300	R:R:I144	R:R:I148	1.47	No	No	0	6	5
301	R:R:I309	R:R:I310	1.47	No	No	0	7	8
302	R:R:K258	R:R:M254	1.44	No	No	0	7	5
303	R:R:A305	R:R:F62	1.39	No	No	0	7	4
304	R:R:L41	R:R:N35	1.37	No	No	0	2	7
305	R:R:E193	R:R:I192	1.37	No	No	0	4	1
306	R:R:E317	R:R:K316	1.35	No	No	0	7	5
307	R:R:R162	R:R:S160	1.32	No	No	0	5	8
308	R:R:R162	R:R:V166	1.31	No	No	0	5	3
309	R:R:R115	R:R:T117	1.29	No	No	0	3	6
310	R:R:R162	R:R:R163	1.07	No	No	0	5	6
311	R:R:F295	R:R:F296	1.07	No	Yes	0	4	5
312	R:R:R78	R:R:Y75	1.03	No	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	7.52429	7	1	6
2	R:R:K39	9.125	4	1	8
3	R:R:I63	4.1	5	0	8
4	R:R:N67	5.3875	4	0	9
5	R:R:I74	3.2175	4	0	7
6	R:R:F80	8.698	5	4	8
7	R:R:P83	4.8825	4	0	6
8	R:R:Y85	8.09	5	4	9
9	R:R:L91	6.2025	4	0	9
10	R:R:D95	8.048	5	0	9
11	R:R:F96	6.12	4	3	7
12	R:R:Y102	8.255	6	0	7
13	R:R:L105	4.8325	4	0	6
14	R:R:W121	7.75	6	1	9
15	R:R:R124	4.83	6	1	6
16	R:R:Q125	11.9675	4	1	4
17	R:R:D129	6.4	5	1	5
18	R:R:S131	3.45	4	0	6
19	R:R:L132	5.105	4	0	7
20	R:R:V136	4.67	5	1	8
21	R:R:H147	7.7025	4	6	7
22	R:R:F151	10.69	4	6	6
23	R:R:V164	4.345	4	0	7
24	R:R:I189	10.1025	4	2	3
25	R:R:M198	6.43	4	1	3
26	R:R:Y202	7.45833	6	1	4
27	R:R:W210	7.802	5	1	6
28	R:R:F213	5.7325	4	1	5
29	R:R:N214	8.86	5	1	7
30	R:R:T217	5.0525	4	1	7
31	R:R:Y225	6.2325	4	0	9
32	R:R:F229	5.164	5	8	6
33	R:R:M253	5.28	4	8	7
34	R:R:F267	7.75333	6	1	9
35	R:R:I268	5.2075	4	0	6
36	R:R:W271	8.87857	7	1	8
37	R:R:L277	6.15	4	1	4
38	R:R:D281	7.68	4	0	4
39	R:R:V282	5.365	4	0	5
40	R:R:E293	6.532	5	1	4
41	R:R:F296	5.87	5	1	5
42	R:R:N303	7.5125	4	1	9
43	R:R:Y311	5.798	5	5	9
44	R:R:M318	5.648	5	4	8
45	L:L:?1	7.53562	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I189	R:R:L201	15.9034	2.85	Yes	No	0	3	1
2	R:R:F33	R:R:L201	20.1226	19.49	No	No	0	6	1
3	R:R:F32	R:R:F33	17.8682	4.29	No	No	0	2	6
4	R:R:F32	R:R:R36	13.3487	5.34	No	No	0	2	3
5	R:R:I192	R:R:R36	11.0837	7.52	No	No	0	1	3
6	R:R:L201	R:R:W121	37.8966	11.39	No	Yes	0	1	9
7	R:R:W121	R:R:Y34	21.1814	3.86	Yes	Yes	1	9	6
8	L:L:?1	R:R:Y34	26.8947	7.55	Yes	Yes	1	0	6
9	L:L:?1	R:R:Q125	32.9082	17.14	Yes	Yes	1	0	4
10	R:R:Q125	R:R:W121	20.4761	14.24	Yes	Yes	1	4	9
11	R:R:C60	R:R:Y102	11.5207	5.38	No	Yes	0	6	7
12	R:R:C60	R:R:F103	10.8652	4.19	No	No	0	6	6
13	R:R:L298	R:R:Y102	10.8279	5.86	No	Yes	0	6	7
14	R:R:L298	R:R:V59	10.556	4.47	No	No	0	6	7
15	R:R:I63	R:R:V59	10.4974	3.07	Yes	No	0	8	7
16	L:L:?1	R:R:L132	47.337	3.96	Yes	Yes	0	0	7
17	R:R:L132	R:R:W271	52.0981	6.83	Yes	Yes	0	7	8
18	R:R:N303	R:R:W271	82.9881	10.17	Yes	Yes	1	9	8
19	R:R:N303	R:R:N307	100	6.81	Yes	No	0	9	9
20	R:R:D95	R:R:N307	49.2752	12.12	Yes	No	0	9	9
21	R:R:D95	R:R:N67	11.3821	6.73	Yes	Yes	0	9	9
22	L:L:?1	R:R:W210	70.4139	11.41	Yes	Yes	1	0	6
23	R:R:W210	R:R:W271	45.962	6.56	Yes	Yes	1	6	8
24	R:R:D95	R:R:L91	48.0316	8.14	Yes	Yes	0	9	9
25	R:R:L91	R:R:N138	84.6545	8.24	Yes	No	0	9	8
26	R:R:N138	R:R:N90	78.728	14.98	No	No	0	8	9
27	R:R:I168	R:R:N90	71.24	9.91	No	No	0	8	9
28	R:R:I168	R:R:V164	69.7318	3.07	No	Yes	0	8	7
29	R:R:P83	R:R:V164	62.1158	3.53	Yes	Yes	0	6	7
30	R:R:E145	R:R:P83	50.3517	4.72	No	Yes	0	8	6
31	R:R:E145	R:R:I84	47.3494	8.2	No	No	0	8	8
32	R:R:I84	R:R:Y85	45.7879	3.63	No	Yes	0	8	9
33	R:R:M318	R:R:Y85	21.0037	3.59	Yes	Yes	4	8	9
34	R:R:L139	R:R:N307	51.1707	8.24	No	No	0	8	9
35	R:R:L139	R:R:L91	40.27	4.15	No	Yes	0	8	9
36	R:R:I74	R:R:M318	13.2261	2.92	Yes	Yes	0	7	8
37	R:R:F80	R:R:Y85	14.3223	22.69	Yes	Yes	4	8	9
38	R:R:L139	R:R:Y311	12.3841	5.86	No	Yes	0	8	9
39	R:R:D129	R:R:Y202	11.7907	8.05	Yes	Yes	1	5	4
40	R:R:M178	R:R:W210	11.8032	6.98	No	Yes	1	5	6
41	R:R:F213	R:R:M178	11.3253	8.71	Yes	No	1	5	5
42	R:R:V136	R:R:W271	37.9392	3.68	Yes	Yes	1	8	8
43	R:R:N214	R:R:W210	13.6863	6.78	Yes	Yes	1	7	6
44	R:R:N214	R:R:V136	11.1423	4.43	Yes	Yes	1	7	8
45	R:R:T217	R:R:V136	60.8332	4.76	Yes	Yes	1	7	8
46	R:R:F213	R:R:T217	10.89	6.49	Yes	Yes	1	5	7
47	R:R:L140	R:R:T217	68.6481	7.37	No	Yes	0	7	7
48	R:R:F151	R:R:H147	27.2375	6.79	Yes	Yes	6	6	7
49	R:R:H147	R:R:L224	53.1835	7.71	Yes	No	0	7	6
50	R:R:L224	R:R:V220	54.7593	2.98	No	No	0	6	5
51	R:R:L140	R:R:V220	57.9002	2.98	No	No	0	7	5
52	R:R:H147	R:R:I228	22.7358	7.95	Yes	No	0	7	9
53	R:R:F151	R:R:V150	21.002	3.93	Yes	No	0	6	8
54	R:R:I228	R:R:V150	21.1192	9.22	No	No	0	9	8
55	R:R:P182	R:R:Y202	20.0249	9.74	No	Yes	1	6	4
56	R:R:I181	R:R:P182	26.5926	3.39	No	No	0	5	6
57	R:R:I181	R:R:W186	19.9236	5.87	No	No	0	5	6
58	R:R:S205	R:R:W186	13.4074	9.88	No	No	0	5	6
59	R:R:S203	R:R:S205	10.0604	4.89	No	No	0	5	5
60	L:L:?1	R:R:M198	18.1897	5.06	Yes	Yes	1	0	3
61	R:R:F229	R:R:L256	32.9117	7.31	Yes	No	0	6	7
62	R:R:L256	R:R:V232	35.7808	4.47	No	No	0	7	7
63	R:R:V150	R:R:V232	38.847	1.6	No	No	0	8	7
64	R:R:F229	R:R:M253	19.7762	4.98	Yes	Yes	8	6	7
65	L:L:?1	R:R:D129	25.8039	6.8	Yes	Yes	1	0	5
66	R:R:D129	R:R:Y206	10.9114	6.9	Yes	No	1	5	7
67	R:R:Q125	R:R:Y202	11.6379	11.27	Yes	Yes	1	4	4
68	R:R:F267	R:R:V136	14.3631	5.24	Yes	Yes	1	9	8
69	R:R:F267	R:R:N303	17.9552	3.62	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I30	R:R:Y34	4.84	1	No	Yes	6	6	2	1
R:R:I30	R:R:W121	5.87	1	No	Yes	6	9	2	2
R:R:K39	R:R:Y34	11.94	1	Yes	Yes	8	6	1	1
R:R:L41	R:R:Y34	8.21	0	No	Yes	2	6	2	1
R:R:T113	R:R:Y34	3.75	1	No	Yes	5	6	1	1
R:R:W121	R:R:Y34	3.86	1	Yes	Yes	9	6	2	1
R:R:P200	R:R:Y34	12.52	1	No	Yes	6	6	2	1
L:L:?1	R:R:Y34	7.55	1	Yes	Yes	0	6	0	1
R:R:K39	R:R:P200	5.02	1	Yes	No	8	6	1	2
R:R:E293	R:R:K39	9.45	1	Yes	Yes	4	8	1	1
L:L:?1	R:R:K39	10.09	1	Yes	Yes	0	8	0	1
R:R:L105	R:R:Y102	3.52	0	Yes	Yes	6	7	2	2
R:R:L297	R:R:Y102	10.55	0	No	Yes	6	7	1	2
R:R:E301	R:R:Y102	21.32	0	No	Yes	7	7	2	2
R:R:R124	R:R:Y104	3.09	1	Yes	No	6	5	1	2
R:R:L105	R:R:R124	7.29	0	Yes	Yes	6	6	2	1
R:R:I128	R:R:L105	4.28	0	No	Yes	6	6	1	2
R:R:R124	R:R:T109	5.17	1	Yes	No	6	5	1	1
L:L:?1	R:R:T109	8.44	1	Yes	No	0	5	0	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	1
L:L:?1	R:R:T113	5.27	1	Yes	No	0	5	0	1
R:R:L116	R:R:R124	6.07	0	No	Yes	6	6	2	1
R:R:Q125	R:R:W121	14.24	1	Yes	Yes	4	9	1	2
R:R:W121	R:R:Y202	7.72	1	Yes	Yes	9	4	2	2
L:L:?1	R:R:R124	3.48	1	Yes	Yes	0	6	0	1
R:R:D129	R:R:Q125	5.22	1	Yes	Yes	5	4	1	1
R:R:Q125	R:R:Y202	11.27	1	Yes	Yes	4	4	1	2
L:L:?1	R:R:Q125	17.14	1	Yes	Yes	0	4	0	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
L:L:?1	R:R:I128	5.11	1	Yes	No	0	6	0	1
R:R:D129	R:R:Y202	8.05	1	Yes	Yes	5	4	1	2
R:R:D129	R:R:Y206	6.9	1	Yes	No	5	7	1	2
L:L:?1	R:R:D129	6.8	1	Yes	Yes	0	5	0	1
R:R:L132	R:R:W271	6.83	0	Yes	Yes	7	8	1	2
R:R:E301	R:R:L132	6.63	0	No	Yes	7	7	2	1
L:L:?1	R:R:L132	3.96	1	Yes	Yes	0	7	0	1
R:R:M178	R:R:T133	9.03	1	No	No	5	6	2	2
R:R:T133	R:R:W210	7.28	1	No	Yes	6	6	2	1
R:R:M178	R:R:W210	6.98	1	No	Yes	5	6	2	1
R:R:L277	R:R:M198	5.65	1	Yes	Yes	4	3	2	1
R:R:D281	R:R:M198	5.54	0	Yes	Yes	4	3	2	1
R:R:E293	R:R:M198	9.47	1	Yes	Yes	4	3	1	1
L:L:?1	R:R:M198	5.06	1	Yes	Yes	0	3	0	1
R:R:Y202	R:R:Y206	3.97	1	Yes	No	4	7	2	2
R:R:L207	R:R:L278	5.54	0	No	No	6	6	2	1
R:R:N214	R:R:W210	6.78	1	Yes	Yes	7	6	2	1
R:R:W210	R:R:W271	6.56	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:W210	11.41	1	Yes	Yes	0	6	0	1
R:R:N214	R:R:W271	14.69	1	Yes	Yes	7	8	2	2
R:R:F296	R:R:G274	4.52	1	Yes	No	5	5	2	1
L:L:?1	R:R:G274	3.67	1	Yes	No	0	5	0	1
R:R:F296	R:R:L277	10.96	1	Yes	Yes	5	4	2	2
L:L:?1	R:R:L278	4.95	1	Yes	No	0	6	0	1
R:R:E293	R:R:K294	5.4	1	Yes	No	4	4	1	1
L:L:?1	R:R:E293	5.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K294	9.08	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	12.87	1	Yes	No	0	6	0	1
R:R:L132	R:R:S131	3	0	Yes	Yes	7	6	1	2
R:R:E293	R:R:L290	2.65	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TD0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	272
Number of Links	312
Number of Hubs	45
Number of Links mediated by Hubs	172
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	113851
Length Of Smallest Path	3
Average Path Length	15.5588
Length of Longest Path	33
Minimum Path Strength	1.19
Average Path Strength	6.941
Maximum Path Strength	18.545
Minimum Path Correlation	0.7
Average Path Correlation	0.924191
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	46.7892
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7899
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle
Gene Ontology	Biological Process	• protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • cellular process • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • synapse • cell junction • glutamatergic synapse • postsynapse • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex binding • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • ion binding • anion binding • phospholipid binding • lipid binding • lysophosphatidic acid binding • carbohydrate derivative binding • small molecule binding • bioactive lipid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • lysophosphatidic acid receptor activity • G-protein alpha-subunit binding • PDZ domain binding • protein domain specific binding • nerve development • cranial nerve development • optic nerve development • nervous system development • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • head development • brain development • cerebellum development • central nervous system development • metencephalon development • hindbrain development • regulation of developmental process • cellular developmental process • cell projection organization • positive regulation of dendritic spine development • cell development • regulation of dendritic spine development • neuron projection development • cellular component organization • positive regulation of developmental process • neurogenesis • neuron differentiation • dendrite development • cell differentiation • cellular component organization or biogenesis • dendritic spine development • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of neuron projection development • regulation of cellular component organization • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of cell projection organization • negative regulation of neuron projection development • regulation of plasma membrane bounded cell projection organization • metabolic process • regulation of metabolic process • cell chemotaxis • chemotaxis • response to external stimulus • taxis • cell migration • cell motility • locomotion • regulation of localization • cellular localization • transport • regulation of transport • regulation of synaptic vesicle cycle • synaptic vesicle cycle • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • vesicle-mediated transport in synapse • localization • establishment of localization in cell • import into cell • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of biological quality • regulation of endocytosis • regulation of receptor-mediated endocytosis • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • endocytosis • receptor-mediated endocytosis • corpus callosum development • forebrain development • telencephalon development • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • cellular component biogenesis • bleb assembly • cellular component assembly • plasma membrane bounded cell projection assembly • cell projection assembly • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of locomotion • regulation of cell motility • positive regulation of smooth muscle cell chemotaxis • regulation of smooth muscle cell chemotaxis • regulation of response to external stimulus • regulation of smooth muscle cell migration • positive regulation of smooth muscle cell migration • positive regulation of chemotaxis • positive regulation of cell migration • muscle cell migration • positive regulation of response to external stimulus • positive regulation of cell motility • smooth muscle cell chemotaxis • regulation of cell migration • regulation of chemotaxis • smooth muscle cell migration • regulation of locomotion • negative regulation of organelle assembly • negative regulation of plasma membrane bounded cell projection assembly • cilium assembly • cilium organization • organelle assembly • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of organelle organization • regulation of plasma membrane bounded cell projection assembly • organelle organization • regulation of cilium assembly • negative regulation of organelle organization • regulation of organelle assembly • negative regulation of cilium assembly • cellular response to oxygen levels • response to oxygen levels • response to abiotic stimulus • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • oligodendrocyte development • glial cell development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • myelination • axon ensheathment • ensheathment of neurons • response to 1-oleoyl-sn-glycerol 3-phosphate • response to organophosphorus • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • postsynaptic membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • cell body • neuronal cell body • cell surface • GABA-ergic synapse • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7TD0_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

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