psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K39	11.94	Yes	No	1	0	8
2	L:L:?1	R:R:L105	3.91	Yes	No	1	0	6
3	L:L:?1	R:R:T109	6.24	Yes	No	1	0	5
4	L:L:?1	R:R:R124	7.72	Yes	Yes	1	0	6
5	L:L:?1	R:R:Q125	7.52	Yes	Yes	1	0	4
6	L:L:?1	R:R:D129	4.79	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y202	4.96	Yes	Yes	1	0	4
8	L:L:?1	R:R:W210	8.04	Yes	Yes	1	0	6
9	L:L:?1	R:R:L278	6.84	Yes	No	0	0	6
10	L:L:?1	R:R:E293	23.38	Yes	No	1	0	4
11	L:L:?1	R:R:K294	6.97	Yes	No	1	0	4
12	L:L:?1	R:R:L297	14.65	Yes	No	0	0	6
13	R:R:F25	R:R:Q23	3.51	No	No	0	7	3
14	R:R:C190	R:R:C24	7.28	No	No	0	3	5
15	R:R:I189	R:R:Y26	4.84	Yes	No	0	3	4
16	R:R:E28	R:R:F32	18.66	No	No	4	4	2
17	R:R:E28	R:R:F33	23.32	No	Yes	4	4	6
18	R:R:I30	R:R:Y34	3.63	No	Yes	0	6	6
19	R:R:F32	R:R:F33	5.36	No	Yes	4	2	6
20	R:R:F33	R:R:L201	20.7	Yes	No	0	6	1
21	R:R:K39	R:R:Y34	7.17	No	Yes	0	8	6
22	R:R:T113	R:R:Y34	3.75	No	Yes	0	5	6
23	R:R:P200	R:R:Y34	4.17	No	Yes	0	6	6
24	R:R:I192	R:R:R36	7.52	No	No	0	1	3
25	R:R:G38	R:R:S37	3.71	No	No	0	4	7
26	R:R:P200	R:R:S37	3.56	No	No	0	6	7
27	R:R:E293	R:R:K39	5.4	No	No	1	4	8
28	R:R:L41	R:R:R114	4.86	No	No	0	2	6
29	R:R:P111	R:R:W45	12.16	No	No	0	4	1
30	R:R:N46	R:R:S49	8.94	No	No	0	2	1
31	R:R:K50	R:R:M53	8.64	No	No	0	3	4
32	R:R:G54	R:R:K50	3.49	No	No	0	4	3
33	R:R:K294	R:R:V52	13.66	No	No	0	4	5
34	R:R:F103	R:R:I57	6.28	No	No	0	6	4
35	R:R:L298	R:R:V59	4.47	No	No	0	6	7
36	R:R:C60	R:R:Y102	4.03	No	Yes	0	6	7
37	R:R:C60	R:R:F103	6.98	No	No	0	6	6
38	R:R:G99	R:R:I63	5.29	No	No	0	7	8
39	R:R:I63	R:R:S304	4.64	No	No	0	8	9
40	R:R:A305	R:R:I63	3.25	No	No	0	7	8
41	R:R:F96	R:R:M64	11.2	No	No	0	7	6
42	R:R:A66	R:R:P308	3.74	No	No	0	8	9
43	R:R:A92	R:R:N67	4.69	No	Yes	0	9	9
44	R:R:D95	R:R:N67	6.73	Yes	Yes	0	9	9
45	R:R:F96	R:R:N67	3.62	No	Yes	0	7	9
46	R:R:N67	R:R:P308	6.52	Yes	No	0	9	9
47	R:R:A92	R:R:V70	3.39	No	No	0	9	9
48	R:R:F80	R:R:I74	3.77	Yes	Yes	3	8	7
49	R:R:I74	R:R:Y85	4.84	Yes	Yes	3	7	9
50	R:R:A89	R:R:I74	4.87	No	Yes	0	7	7
51	R:R:F80	R:R:N77	9.67	Yes	No	3	8	6
52	R:R:N77	R:R:T321	7.31	No	No	3	6	7
53	R:R:H81	R:R:R78	18.05	No	No	0	8	6
54	R:R:F80	R:R:R79	8.55	Yes	No	0	8	6
55	R:R:E317	R:R:R79	12.79	No	No	0	7	6
56	R:R:F80	R:R:Y85	19.6	Yes	Yes	3	8	9
57	R:R:F80	R:R:M318	11.2	Yes	Yes	0	8	8
58	R:R:F80	R:R:T321	5.19	Yes	No	3	8	7
59	R:R:H81	R:R:Y86	6.53	No	No	0	8	4
60	R:R:F82	R:R:P83	4.33	No	Yes	5	7	6
61	R:R:F82	R:R:M159	7.46	No	No	5	7	6
62	R:R:M159	R:R:P83	8.39	No	Yes	5	6	6
63	R:R:P83	R:R:V164	5.3	Yes	No	0	6	7
64	R:R:I84	R:R:Y85	3.63	No	Yes	0	8	9
65	R:R:E145	R:R:I84	10.93	Yes	No	0	8	8
66	R:R:D315	R:R:Y85	5.75	No	Yes	0	8	9
67	R:R:N161	R:R:Y86	5.81	No	No	0	3	4
68	R:R:V164	R:R:Y86	3.79	No	No	0	7	4
69	R:R:E145	R:R:L87	6.63	Yes	No	0	8	8
70	R:R:I142	R:R:M88	4.37	Yes	No	2	8	8
71	R:R:M88	R:R:Y311	5.99	No	Yes	2	8	9
72	R:R:N138	R:R:N90	12.26	Yes	No	0	8	9
73	R:R:I168	R:R:N90	12.74	No	No	0	8	9
74	R:R:N90	R:R:W172	6.78	No	No	0	9	9
75	R:R:D95	R:R:L91	4.07	Yes	Yes	0	9	9
76	R:R:L91	R:R:N138	6.87	Yes	Yes	0	9	8
77	R:R:L139	R:R:L91	5.54	Yes	Yes	2	8	9
78	R:R:I142	R:R:L91	4.28	Yes	Yes	2	8	9
79	R:R:L91	R:R:Y311	3.52	Yes	Yes	2	9	9
80	R:R:D95	R:R:S304	5.89	Yes	No	0	9	9
81	R:R:D95	R:R:N307	8.08	Yes	No	0	9	9
82	R:R:F97	R:R:T130	3.89	No	No	0	7	6
83	R:R:F97	R:R:W172	6.01	No	No	0	7	9
84	R:R:A98	R:R:S131	3.42	No	No	0	8	6
85	R:R:A98	R:R:S304	3.42	No	No	0	8	9
86	R:R:A101	R:R:I128	3.25	No	No	0	5	6
87	R:R:A101	R:R:S131	3.42	No	No	0	5	6
88	R:R:M106	R:R:Y102	5.99	No	Yes	0	6	7
89	R:R:L297	R:R:Y102	9.38	No	Yes	0	6	7
90	R:R:L298	R:R:Y102	7.03	No	Yes	0	6	7
91	R:R:E301	R:R:Y102	24.69	No	Yes	0	7	7
92	R:R:F103	R:R:F107	4.29	No	No	0	6	5
93	R:R:N108	R:R:Y104	9.3	No	No	0	5	5
94	R:R:L105	R:R:R124	6.07	No	Yes	1	6	6
95	R:R:I128	R:R:L105	7.14	No	No	0	6	6
96	R:R:N108	R:R:R124	7.23	No	Yes	0	5	6
97	R:R:K294	R:R:T109	7.51	No	No	1	4	5
98	R:R:G110	R:R:P111	4.06	Yes	No	0	5	4
99	R:R:R124	R:R:T113	3.88	Yes	No	0	6	5
100	R:R:L116	R:R:W121	4.56	No	Yes	1	6	9
101	R:R:L116	R:R:R124	4.86	No	Yes	1	6	6
102	R:R:T117	R:R:T120	4.71	No	No	0	6	4
103	R:R:R124	R:R:W121	8	Yes	Yes	1	6	9
104	R:R:Q125	R:R:W121	15.33	Yes	Yes	1	4	9
105	R:R:P200	R:R:W121	5.4	No	Yes	0	6	9
106	R:R:L201	R:R:W121	10.25	No	Yes	0	1	9
107	R:R:L122	R:R:Y202	3.52	No	Yes	0	5	4
108	R:R:L123	R:R:L127	4.15	No	No	0	4	5
109	R:R:Q125	R:R:R124	8.18	Yes	Yes	1	4	6
110	R:R:Q125	R:R:Y202	6.76	Yes	Yes	1	4	4
111	R:R:D129	R:R:G126	5.03	Yes	No	0	5	6
112	R:R:D129	R:R:Y202	8.05	Yes	Yes	1	5	4
113	R:R:D129	R:R:Y206	9.2	Yes	Yes	1	5	7
114	R:R:I176	R:R:T130	4.56	No	No	0	3	6
115	R:R:L132	R:R:W210	3.42	No	Yes	1	7	6
116	R:R:L132	R:R:W271	6.83	No	Yes	1	7	8
117	R:R:E301	R:R:L132	6.63	No	No	0	7	7
118	R:R:A175	R:R:T133	3.36	No	No	0	8	6
119	R:R:M178	R:R:T133	6.02	Yes	No	1	5	6
120	R:R:T133	R:R:W210	6.06	No	Yes	1	6	6
121	R:R:A134	R:R:W172	3.89	No	No	0	7	9
122	R:R:N214	R:R:V136	7.39	Yes	Yes	1	7	8
123	R:R:T217	R:R:V136	4.76	No	Yes	0	7	8
124	R:R:F267	R:R:V136	5.24	Yes	Yes	1	9	8
125	R:R:V136	R:R:W271	4.9	Yes	Yes	1	8	8
126	R:R:A137	R:R:I171	4.87	No	No	0	5	7
127	R:R:I171	R:R:N138	9.91	No	Yes	0	7	8
128	R:R:L139	R:R:N307	8.24	Yes	No	0	8	9
129	R:R:L139	R:R:Y311	3.52	Yes	Yes	2	8	9
130	R:R:I144	R:R:L140	7.14	No	No	0	6	7
131	R:R:A141	R:R:I171	3.25	No	No	0	8	7
132	R:R:I142	R:R:R146	5.01	Yes	No	2	8	9
133	R:R:I142	R:R:Y311	6.04	Yes	Yes	2	8	9
134	R:R:R146	R:R:Y225	12.35	No	Yes	0	9	9
135	R:R:R146	R:R:Y311	7.2	No	Yes	2	9	9
136	R:R:F151	R:R:H147	15.84	Yes	Yes	6	6	7
137	R:R:H147	R:R:L224	5.14	Yes	No	0	7	6
138	R:R:H147	R:R:H227	9.55	Yes	No	6	7	5
139	R:R:H147	R:R:I228	5.3	Yes	No	0	7	9
140	R:R:R152	R:R:T149	6.47	No	No	0	5	8
141	R:R:F151	R:R:V150	3.93	Yes	No	0	6	8
142	R:R:I228	R:R:V150	4.61	No	No	0	9	8
143	R:R:F151	R:R:H227	14.71	Yes	No	6	6	5
144	R:R:F151	R:R:Y231	12.38	Yes	No	0	6	6
145	R:R:R152	R:R:T157	11.64	No	No	0	5	4
146	R:R:Q154	R:R:T157	11.34	No	No	0	4	4
147	R:R:H156	R:R:L155	9	No	No	0	4	8
148	R:R:R162	R:R:S160	5.27	No	No	0	5	8
149	R:R:M178	R:R:Y206	3.59	Yes	Yes	1	5	7
150	R:R:F209	R:R:M178	4.98	No	Yes	0	6	5
151	R:R:M178	R:R:W210	3.49	Yes	Yes	1	5	6
152	R:R:I181	R:R:P182	3.39	No	No	0	5	6
153	R:R:P182	R:R:Y202	13.91	No	Yes	1	6	4
154	R:R:P182	R:R:Y206	18.08	No	Yes	1	6	7
155	R:R:G185	R:R:V184	3.68	No	No	0	5	5
156	R:R:S205	R:R:W186	8.65	No	No	0	5	6
157	R:R:W186	R:R:Y206	3.86	No	Yes	0	6	7
158	R:R:I189	R:R:N187	7.08	Yes	No	0	3	6
159	R:R:C188	R:R:C195	7.28	No	No	0	5	9
160	R:R:I189	R:R:L201	4.28	Yes	No	0	3	1
161	R:R:D191	R:R:E193	12.99	No	No	0	4	4
162	R:R:E193	R:R:N194	6.57	No	No	0	4	3
163	R:R:C195	R:R:S203	3.44	No	No	0	9	5
164	R:R:A199	R:R:S196	3.42	No	No	0	4	5
165	R:R:D281	R:R:S196	4.42	Yes	No	0	4	5
166	R:R:D281	R:R:N197	12.12	Yes	No	0	4	5
167	R:R:L277	R:R:M198	5.65	No	No	0	4	3
168	R:R:D281	R:R:M198	9.7	Yes	No	0	4	3
169	R:R:E293	R:R:M198	14.89	No	No	0	4	3
170	R:R:A199	R:R:Y202	4	No	Yes	0	4	4
171	R:R:Y202	R:R:Y206	8.94	Yes	Yes	1	4	7
172	R:R:S203	R:R:S205	4.89	No	No	0	5	5
173	R:R:D204	R:R:V282	8.76	No	Yes	0	4	5
174	R:R:L207	R:R:L278	5.54	No	No	0	6	6
175	R:R:V208	R:R:V282	4.81	No	Yes	0	4	5
176	R:R:W210	R:R:W271	4.69	Yes	Yes	1	6	8
177	R:R:F213	R:R:T217	5.19	No	No	0	5	7
178	R:R:F267	R:R:N214	7.25	Yes	Yes	1	9	7
179	R:R:N214	R:R:W271	9.04	Yes	Yes	1	7	8
180	R:R:L275	R:R:N214	12.36	No	Yes	1	6	7
181	R:R:F218	R:R:V222	7.87	No	No	0	5	4
182	R:R:F218	R:R:F267	10.72	No	Yes	0	5	9
183	R:R:F218	R:R:I268	3.77	No	No	0	5	6
184	R:R:L264	R:R:V222	4.47	No	No	0	7	4
185	R:R:V260	R:R:Y225	5.05	No	Yes	0	8	9
186	R:R:V263	R:R:Y225	5.05	No	Yes	0	8	9
187	R:R:F229	R:R:M253	6.22	Yes	No	0	6	7
188	R:R:F229	R:R:L256	8.53	Yes	No	0	6	7
189	R:R:F229	R:R:L257	7.31	Yes	No	0	6	7
190	R:R:R235	R:R:Y231	14.4	No	No	0	7	6
191	R:R:L256	R:R:V232	4.47	No	Yes	0	7	7
192	R:R:M253	R:R:R233	6.2	No	No	0	7	5
193	R:R:D251	R:R:M253	4.16	No	No	0	5	7
194	R:R:R314	R:R:S255	9.22	No	No	0	7	7
195	R:R:T259	R:R:Y313	4.99	No	No	8	8	5
196	R:R:R314	R:R:T259	12.94	No	No	8	7	8
197	R:R:I262	R:R:I310	4.42	No	No	0	6	8
198	R:R:I262	R:R:Y313	8.46	No	No	0	6	5
199	R:R:V263	R:R:Y311	6.31	No	Yes	0	8	9
200	R:R:F267	R:R:W271	17.04	Yes	Yes	1	9	8
201	R:R:I268	R:R:T272	6.08	No	No	0	6	5
202	R:R:C270	R:R:N303	9.45	No	No	0	9	9
203	R:R:L275	R:R:W271	4.56	No	Yes	1	6	8
204	R:R:A300	R:R:W271	3.89	No	Yes	0	7	8
205	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
206	R:R:P273	R:R:T272	3.5	Yes	No	0	9	5
207	R:R:F296	R:R:P273	8.67	No	Yes	0	5	9
208	R:R:L299	R:R:P273	3.28	No	Yes	0	7	9
209	R:R:F296	R:R:L277	7.31	No	No	0	5	4
210	R:R:L280	R:R:V289	4.47	No	No	0	5	4
211	R:R:D281	R:R:V289	4.38	Yes	No	0	4	4
212	R:R:C284	R:R:P285	3.77	No	No	0	4	3
213	R:R:C284	R:R:C287	7.28	No	No	0	4	5
214	R:R:A291	R:R:Y292	8.01	No	No	0	2	3
215	R:R:F296	R:R:Y292	4.13	No	No	0	5	3
216	R:R:F302	R:R:M306	13.68	No	No	0	5	6
217	R:R:N303	R:R:N307	6.81	No	No	0	9	9
218	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
219	R:R:M318	R:R:S312	6.13	Yes	No	0	8	7
220	R:R:R314	R:R:Y313	16.46	No	No	8	7	5
221	R:R:F322	R:R:M318	4.98	No	Yes	0	6	8
222	R:R:S119	R:R:T117	3.2	No	No	0	1	6
223	R:R:E145	R:R:P83	3.14	Yes	Yes	0	8	6
224	R:R:T236	R:R:T252	3.14	No	No	7	5	5
225	R:R:A94	R:R:N138	3.13	No	Yes	0	8	8
226	R:R:I181	R:R:V177	3.07	No	No	0	5	4
227	R:R:I212	R:R:V208	3.07	No	No	0	4	4
228	R:R:M318	R:R:V70	3.04	Yes	No	0	8	9
229	R:R:L87	R:R:V167	2.98	No	No	0	8	6
230	R:R:L140	R:R:V220	2.98	No	No	0	7	5
231	R:R:L207	R:R:V282	2.98	No	Yes	0	6	5
232	R:R:L224	R:R:V220	2.98	No	No	0	6	5
233	R:R:L257	R:R:V261	2.98	No	No	0	7	5
234	R:R:N46	R:R:V48	2.96	No	No	0	2	3
235	R:R:N77	R:R:V76	2.96	No	No	0	6	5
236	R:R:L41	R:R:T43	2.95	No	No	0	2	3
237	R:R:L116	R:R:T120	2.95	No	No	0	6	4
238	R:R:L140	R:R:T217	2.95	No	No	0	7	7
239	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
240	R:R:A42	R:R:H40	2.93	No	No	0	4	2
241	R:R:I74	R:R:M71	2.92	Yes	No	0	7	7
242	R:R:G56	R:R:Y102	2.9	No	Yes	0	6	7
243	R:R:L100	R:R:M64	2.83	No	No	0	4	6
244	R:R:L139	R:R:M221	2.83	Yes	No	0	8	9
245	R:R:L264	R:R:M221	2.83	No	No	0	7	9
246	R:R:E145	R:R:T149	2.82	Yes	No	0	8	8
247	R:R:L298	R:R:L55	2.77	No	No	0	6	4
248	R:R:A66	R:R:F62	2.77	No	No	0	8	4
249	R:R:A305	R:R:F62	2.77	No	No	0	7	4
250	R:R:A73	R:R:F322	2.77	No	No	0	7	6
251	R:R:A305	R:R:F302	2.77	No	No	0	7	5
252	R:R:L290	R:R:N197	2.75	No	No	0	3	5
253	R:R:A143	R:R:Y225	2.67	No	Yes	0	8	9
254	R:R:F33	R:R:I192	2.51	Yes	No	0	6	1
255	R:R:I148	R:R:R163	2.51	No	No	0	5	6
256	R:R:F107	R:R:M53	2.49	No	No	0	5	4
257	R:R:F213	R:R:M174	2.49	No	No	0	5	4
258	R:R:F97	R:R:L127	2.44	No	No	0	7	5
259	R:R:M153	R:R:Y231	2.39	No	No	0	7	6
260	R:R:L41	R:R:Y34	2.34	No	Yes	0	2	6
261	R:R:E28	R:R:F25	2.33	No	No	0	4	7
262	R:R:N112	R:R:W45	2.26	No	No	0	4	1
263	R:R:G274	R:R:P273	2.03	No	Yes	0	5	9
264	R:R:A42	R:R:G110	1.95	No	Yes	0	4	5
265	R:R:G110	R:R:S49	1.86	Yes	No	0	5	1
266	R:R:G110	R:R:T109	1.82	Yes	No	0	5	5
267	R:R:G179	R:R:T130	1.82	No	No	0	7	6
268	R:R:G265	R:R:I268	1.76	No	No	0	4	6
269	R:R:A31	R:R:S29	1.71	No	No	0	2	4
270	R:R:C283	R:R:V282	1.71	No	Yes	0	4	5
271	R:R:C287	R:R:V289	1.71	No	No	0	5	4
272	R:R:C270	R:R:I269	1.64	No	No	0	9	5
273	R:R:A31	R:R:I30	1.62	No	No	0	2	6
274	R:R:A266	R:R:I310	1.62	No	No	0	6	8
275	R:R:A93	R:R:M71	1.61	No	No	0	6	7
276	R:R:A320	R:R:K316	1.61	No	No	0	4	5
277	R:R:V150	R:R:V232	1.6	No	Yes	0	8	7
278	R:R:V164	R:R:V165	1.6	No	No	0	7	1
279	R:R:T236	R:R:V232	1.59	No	Yes	7	5	7
280	R:R:T252	R:R:V232	1.59	No	Yes	7	5	7
281	R:R:T272	R:R:V276	1.59	No	No	0	5	6
282	R:R:C283	R:R:L279	1.59	No	No	0	4	6
283	R:R:A211	R:R:L275	1.58	No	No	0	4	6
284	R:R:A211	R:R:L279	1.58	No	No	0	4	6
285	R:R:P285	R:R:Q286	1.58	No	No	0	3	4
286	R:R:I189	R:R:V118	1.54	Yes	No	0	3	2
287	R:R:I212	R:R:V216	1.54	No	No	0	4	4
288	R:R:A291	R:R:D288	1.54	No	No	0	2	1
289	R:R:I57	R:R:T58	1.52	No	No	0	4	5
290	R:R:M174	R:R:V170	1.52	No	No	0	4	3
291	R:R:F229	R:R:G230	1.51	Yes	No	0	6	2
292	R:R:L122	R:R:S183	1.5	No	No	0	5	6
293	R:R:L68	R:R:V72	1.49	No	No	0	4	5
294	R:R:I57	R:R:I61	1.47	No	No	0	4	4
295	R:R:D251	R:R:M254	1.39	No	No	0	5	5
296	R:R:F295	R:R:V48	1.31	No	No	0	4	3
297	R:R:E193	R:R:Q23	1.27	No	No	0	4	3
298	R:R:I74	R:R:Y75	1.21	Yes	No	0	7	3
299	R:R:Q234	R:R:R235	1.17	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.91333	12	1	0
2	R:R:F33	12.9725	4	4	6
3	R:R:Y34	4.212	5	0	6
4	R:R:N67	5.39	4	0	9
5	R:R:I74	3.522	5	3	7
6	R:R:F80	9.66333	6	3	8
7	R:R:P83	5.29	4	5	6
8	R:R:Y85	8.455	4	3	9
9	R:R:L91	4.856	5	2	9
10	R:R:D95	5.542	5	0	9
11	R:R:Y102	9.00333	6	0	7
12	R:R:G110	2.4225	4	0	5
13	R:R:W121	8.708	5	1	9
14	R:R:R124	6.56286	7	1	6
15	R:R:Q125	9.4475	4	1	4
16	R:R:D129	6.7675	4	1	5
17	R:R:V136	5.5725	4	1	8
18	R:R:N138	8.0425	4	0	8
19	R:R:L139	5.0325	4	2	8
20	R:R:I142	4.925	4	2	8
21	R:R:E145	5.88	4	0	8
22	R:R:H147	8.9575	4	6	7
23	R:R:F151	11.715	4	6	6
24	R:R:M178	4.52	4	1	5
25	R:R:I189	4.435	4	0	3
26	R:R:Y202	7.16286	7	1	4
27	R:R:Y206	8.734	5	1	7
28	R:R:W210	5.14	5	1	6
29	R:R:N214	9.01	4	1	7
30	R:R:Y225	6.28	4	0	9
31	R:R:F229	5.8925	4	0	6
32	R:R:V232	2.3125	4	7	7
33	R:R:F267	10.0625	4	1	9
34	R:R:W271	7.3575	8	1	8
35	R:R:P273	4.37	4	0	9
36	R:R:D281	7.655	4	0	4
37	R:R:V282	4.565	4	0	5
38	R:R:Y311	5.17286	7	2	9
39	R:R:M318	6.3375	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R124	28.7718	7.72	Yes	Yes	1	0	6
2	R:R:R124	R:R:W121	21.3156	8	Yes	Yes	1	6	9
3	R:R:L201	R:R:W121	36.091	10.25	No	Yes	0	1	9
4	R:R:F33	R:R:L201	24.3661	20.7	Yes	No	0	6	1
5	R:R:E28	R:R:F33	14.6716	23.32	No	Yes	4	4	6
6	R:R:E28	R:R:F25	12.2255	2.33	No	No	0	4	7
7	L:L:?1	R:R:Q125	20.815	7.52	Yes	Yes	1	0	4
8	R:R:Q125	R:R:W121	22.4064	15.33	Yes	Yes	1	4	9
9	R:R:I189	R:R:L201	10.0156	4.28	Yes	No	0	3	1
10	L:L:?1	R:R:K39	12.2161	11.94	Yes	No	1	0	8
11	R:R:K39	R:R:Y34	12.32	7.17	No	Yes	0	8	6
12	L:L:?1	R:R:T109	15.8521	6.24	Yes	No	1	0	5
13	R:R:G110	R:R:T109	14.7471	1.82	Yes	No	0	5	5
14	L:L:?1	R:R:L297	11.0544	14.65	Yes	No	0	0	6
15	R:R:C60	R:R:Y102	13.0755	4.03	No	Yes	0	6	7
16	R:R:C60	R:R:F103	11.64	6.98	No	No	0	6	6
17	L:L:?1	R:R:W210	82.5471	8.04	Yes	Yes	1	0	6
18	R:R:W210	R:R:W271	89.9797	4.69	Yes	Yes	1	6	8
19	R:R:N303	R:R:W271	100	7.91	No	Yes	0	9	8
20	R:R:N303	R:R:N307	98.6117	6.81	No	No	0	9	9
21	R:R:D95	R:R:N307	66.185	8.08	Yes	No	0	9	9
22	R:R:D95	R:R:S304	10.6672	5.89	Yes	No	0	9	9
23	R:R:D95	R:R:N67	53.7281	6.73	Yes	Yes	0	9	9
24	R:R:A92	R:R:N67	46.8291	4.69	No	Yes	0	9	9
25	R:R:A92	R:R:V70	45.6722	3.39	No	No	0	9	9
26	R:R:M318	R:R:V70	44.4869	3.04	Yes	No	0	8	9
27	R:R:F80	R:R:M318	39.9065	11.2	Yes	Yes	0	8	8
28	R:R:F80	R:R:Y85	25.5419	19.6	Yes	Yes	3	8	9
29	R:R:I84	R:R:Y85	23.3366	3.63	No	Yes	0	8	9
30	R:R:E145	R:R:I84	21.9814	10.93	Yes	No	0	8	8
31	R:R:E145	R:R:P83	12.8205	3.14	Yes	Yes	0	8	6
32	R:R:L139	R:R:N307	34.0464	8.24	Yes	No	0	8	9
33	R:R:L139	R:R:L91	17.8118	5.54	Yes	Yes	2	8	9
34	R:R:L139	R:R:Y311	16.9807	3.52	Yes	Yes	2	8	9
35	R:R:D95	R:R:L91	26.5996	4.07	Yes	Yes	0	9	9
36	R:R:L91	R:R:N138	34.103	6.87	Yes	Yes	0	9	8
37	R:R:N138	R:R:N90	22.888	12.26	Yes	No	0	8	9
38	R:R:N90	R:R:W172	18.3359	6.78	No	No	0	9	9
39	R:R:F97	R:R:W172	13.746	6.01	No	No	0	7	9
40	R:R:E301	R:R:L132	13.543	6.63	No	No	0	7	7
41	R:R:E301	R:R:Y102	12.7355	24.69	No	Yes	0	7	7
42	L:L:?1	R:R:Y202	10.7995	4.96	Yes	Yes	1	0	4
43	R:R:M178	R:R:W210	10.1478	3.49	Yes	Yes	1	5	6
44	R:R:V136	R:R:W271	51.8204	4.9	Yes	Yes	1	8	8
45	R:R:T217	R:R:V136	55.9475	4.76	No	Yes	0	7	8
46	R:R:L140	R:R:T217	51.2443	2.95	No	No	0	7	7
47	R:R:L140	R:R:V220	48.836	2.98	No	No	0	7	5
48	R:R:L224	R:R:V220	47.6177	2.98	No	No	0	6	5
49	R:R:H147	R:R:L224	46.39	5.14	Yes	No	0	7	6
50	R:R:F151	R:R:H147	24.6163	15.84	Yes	Yes	6	6	7
51	R:R:F151	R:R:V150	18.1187	3.93	Yes	No	0	6	8
52	R:R:H147	R:R:I228	19.167	5.3	Yes	No	0	7	9
53	R:R:I228	R:R:V150	17.9629	4.61	No	No	0	9	8
54	L:L:?1	R:R:E293	20.4939	23.38	Yes	No	1	0	4
55	R:R:E293	R:R:M198	20.6356	14.89	No	No	0	4	3
56	R:R:D281	R:R:M198	12.6458	9.7	Yes	No	0	4	3
57	L:L:?1	R:R:L278	11.3992	6.84	Yes	No	0	0	6
58	R:R:L207	R:R:L278	10.0864	5.54	No	No	0	6	6
59	R:R:F218	R:R:F267	11.5833	10.72	No	Yes	0	5	9
60	R:R:F218	R:R:I268	10.4878	3.77	No	No	0	5	6
61	R:R:V150	R:R:V232	33.2719	1.6	No	Yes	0	8	7
62	R:R:L256	R:R:V232	25.3294	4.47	No	Yes	0	7	7
63	R:R:F229	R:R:L256	22.7983	8.53	Yes	No	0	6	7
64	R:R:F229	R:R:M253	11.4653	6.22	Yes	No	0	6	7
65	R:R:L132	R:R:W271	13.3447	6.83	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K39	11.94	1	Yes	No	0	8	0	1
L:L:?1	R:R:L105	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:T109	6.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:R124	7.72	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q125	7.52	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D129	4.79	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y202	4.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W210	8.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L278	6.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:E293	23.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:K294	6.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:L297	14.65	1	Yes	No	0	6	0	1
R:R:K39	R:R:Y34	7.17	1	No	Yes	8	6	1	2
R:R:T113	R:R:Y34	3.75	0	No	Yes	5	6	2	2
R:R:E293	R:R:K39	5.4	1	No	No	4	8	1	1
R:R:K294	R:R:V52	13.66	1	No	No	4	5	1	2
R:R:L297	R:R:Y102	9.38	0	No	Yes	6	7	1	2
R:R:L105	R:R:R124	6.07	1	No	Yes	6	6	1	1
R:R:I128	R:R:L105	7.14	0	No	No	6	6	2	1
R:R:N108	R:R:R124	7.23	0	No	Yes	5	6	2	1
R:R:K294	R:R:T109	7.51	1	No	No	4	5	1	1
R:R:R124	R:R:T113	3.88	1	Yes	No	6	5	1	2
R:R:L116	R:R:W121	4.56	1	No	Yes	6	9	2	2
R:R:L116	R:R:R124	4.86	1	No	Yes	6	6	2	1
R:R:R124	R:R:W121	8	1	Yes	Yes	6	9	1	2
R:R:Q125	R:R:W121	15.33	1	Yes	Yes	4	9	1	2
R:R:L122	R:R:Y202	3.52	0	No	Yes	5	4	2	1
R:R:Q125	R:R:R124	8.18	1	Yes	Yes	4	6	1	1
R:R:Q125	R:R:Y202	6.76	1	Yes	Yes	4	4	1	1
R:R:D129	R:R:G126	5.03	1	Yes	No	5	6	1	2
R:R:D129	R:R:Y202	8.05	1	Yes	Yes	5	4	1	1
R:R:D129	R:R:Y206	9.2	1	Yes	Yes	5	7	1	2
R:R:L132	R:R:W210	3.42	1	No	Yes	7	6	2	1
R:R:L132	R:R:W271	6.83	1	No	Yes	7	8	2	2
R:R:M178	R:R:T133	6.02	1	Yes	No	5	6	2	2
R:R:T133	R:R:W210	6.06	1	No	Yes	6	6	2	1
R:R:M178	R:R:Y206	3.59	1	Yes	Yes	5	7	2	2
R:R:M178	R:R:W210	3.49	1	Yes	Yes	5	6	2	1
R:R:P182	R:R:Y202	13.91	1	No	Yes	6	4	2	1
R:R:P182	R:R:Y206	18.08	1	No	Yes	6	7	2	2
R:R:E293	R:R:M198	14.89	1	No	No	4	3	1	2
R:R:A199	R:R:Y202	4	0	No	Yes	4	4	2	1
R:R:Y202	R:R:Y206	8.94	1	Yes	Yes	4	7	1	2
R:R:L207	R:R:L278	5.54	0	No	No	6	6	2	1
R:R:W210	R:R:W271	4.69	1	Yes	Yes	6	8	1	2
R:R:G110	R:R:T109	1.82	0	Yes	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YU6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	267
Number of Links	299
Number of Hubs	39
Number of Links mediated by Hubs	153
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	47293
Length Of Smallest Path	3
Average Path Length	12.7632
Length of Longest Path	31
Minimum Path Strength	1.495
Average Path Strength	6.71958
Maximum Path Strength	22.01
Minimum Path Correlation	0.7
Average Path Correlation	0.925922
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	52.3119
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.0904
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	K6L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	K6L
Name	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier
Formula	C20 H34 N O6 P
Molecular Weight	415.461
SMILES
PubChem	141702624
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	1
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92633
Sequence	>7YU6_nogp_Chain_R Q C F Y N E S I A F F Y N R S G K H L A T E W N T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N R R F H F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T G P N T R R L T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R M Q L H T R M S N R R V V V V I V V I W T M A I V M G A I P S V G W N C I C D I E N C S N M A P L Y S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C P Q C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E M S A T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4Z34	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9780307	-	-	3	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z35	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-9910539	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	4Z36	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-3080573	-	-	2.9	2015-06-03	doi.org/10.1016/j.cell.2015.06.002
	9IZF	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	Gi1/β1/γ2	3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZF (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.14	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZG (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	NKP	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	7TD0	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD0 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		2.83	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7YU3	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU3 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU4	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	-	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU5 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.7	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU6 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		3.9	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU7 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		4.5	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-	Gi1/β1/γ2	5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	7YU8 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	ONO-0740556	-		5.6	2022-10-05	doi.org/10.1038/s41467-022-33121-2
	9J5V	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-	Gi1/β1/γ2	2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9J5V (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	CpY	-		2.86	2024-11-27	doi.org/10.1038/s42003-024-07152-y
	9IZH	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164
	9IZH (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.04	2025-01-01	doi.org/10.1016/j.jsb.2024.108164

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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