CodeK6L
Name[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Synonyms
Identifier[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
FormulaC20 H34 N O6 P
Molecular Weight415.461
SMILESCCCCCCc1ccccc1CCCCC(=O)N[C@H](CO)COP(=O)(O)O
PubChem141702624
Formal Charge0
Total Atoms62
Total Chiral Atoms1
Total Bonds62
Total Aromatic Bonds6
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU3 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - Gi1/Beta1/Gamma2 3.5 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 7.17 2 No Yes 8 6 1 1
R:R:L41 R:R:Y34 3.52 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 7.49 0 No Yes 5 6 2 1
R:R:P200 R:R:Y34 5.56 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:L105 R:R:Y102 3.52 0 No Yes 6 7 2 2
R:R:M106 R:R:Y102 5.99 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:M106 R:R:T109 3.01 0 No Yes 6 5 2 1
R:R:N108 R:R:R124 7.23 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 6.01 2 No Yes 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes Yes 0 5 0 1
R:R:R124 R:R:T113 3.88 2 Yes No 6 5 1 2
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 5.4 0 No Yes 6 9 2 2
R:R:L122 R:R:Y202 3.52 0 No Yes 5 4 2 1
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 5.64 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 3.35 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 8.05 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 No Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 No Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 13.91 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 20.86 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No Yes 4 3 1 2
R:R:A199 R:R:Y202 4 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 7.94 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 6.92 2 No No 6 6 1 1
R:R:L207 R:R:V282 2.98 2 No Yes 6 5 1 2
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 4.88 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 15.63 2 Yes No 0 6 0 1
R:R:G110 R:R:T109 1.82 0 No Yes 5 5 2 1
R:R:K39 R:R:L290 1.41 2 No No 8 3 1 2
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.10
Average Nodes In Shell38.00
Average Hubs In Shell16.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU4 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - - 3.7 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 8.36 1 No Yes 8 6 1 1
R:R:L41 R:R:Y34 3.52 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 7.49 0 No Yes 5 6 2 1
R:R:P200 R:R:Y34 5.56 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 10.95 1 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 1 No No 4 5 1 2
R:R:L105 R:R:Y102 3.52 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 10.55 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:N108 R:R:R124 7.23 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 4.5 1 No No 4 5 1 1
L:L:?1 R:R:T109 4.16 1 Yes No 0 5 0 1
R:R:L116 R:R:W121 4.56 1 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 1 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 1 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 1 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 5.4 0 No Yes 6 9 2 2
R:R:L122 R:R:Y202 3.52 0 No Yes 5 4 2 1
R:R:Q125 R:R:R124 8.18 1 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 6 1 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 5.64 1 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 8.46 1 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 1 Yes No 5 6 1 2
R:R:D129 R:R:Y202 8.05 1 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 1 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 6.71 1 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 1 No Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 1 No Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 1 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 1 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 1 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 1 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 13.91 1 No Yes 6 4 2 1
R:R:P182 R:R:Y206 20.86 1 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No No 4 3 1 2
R:R:A199 R:R:Y202 4 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 7.94 1 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.14 1 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 5.54 0 No No 6 6 2 1
R:R:W210 R:R:W271 4.69 1 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 9.65 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 3.91 1 Yes No 0 6 0 1
L:L:?1 R:R:E293 26.19 1 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 1 Yes No 0 4 0 1
L:L:?1 R:R:L297 13.68 1 Yes No 0 6 0 1
R:R:G110 R:R:T109 1.82 0 No No 5 5 2 1
R:R:K39 R:R:S37 1.53 1 No No 8 7 1 2
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.68
Average Nodes In Shell36.00
Average Hubs In Shell13.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell43.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU5 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - Gi1/Beta1/Gamma2 3.7 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 10.75 2 No Yes 8 6 1 1
R:R:T113 R:R:Y34 7.49 2 Yes Yes 5 6 1 1
R:R:P200 R:R:Y34 5.56 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:M106 R:R:Y102 7.18 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:M106 R:R:T109 3.01 0 No Yes 6 5 2 1
R:R:N108 R:R:R124 8.44 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 4.5 2 No Yes 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes Yes 0 5 0 1
R:R:L116 R:R:T113 2.95 2 Yes Yes 6 5 2 1
R:R:R124 R:R:T113 3.88 2 Yes Yes 6 5 1 1
L:L:?1 R:R:T113 3.12 2 Yes Yes 0 5 0 1
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 16.43 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 4.05 0 No Yes 6 9 2 2
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 6.76 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 9.2 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 Yes Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 Yes Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 11.13 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 18.08 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No Yes 4 3 1 2
R:R:A199 R:R:Y202 5.34 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 10.92 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 4.15 2 No No 6 6 1 1
R:R:L207 R:R:V282 2.98 2 No Yes 6 5 1 2
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 16.61 2 Yes No 0 6 0 1
R:R:L41 R:R:Y34 2.34 0 No Yes 2 6 2 1
R:R:G110 R:R:T109 1.82 0 No Yes 5 5 2 1
R:R:A211 R:R:L278 1.58 0 No No 4 6 2 1
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.95
Average Nodes In Shell37.00
Average Hubs In Shell18.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU6 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - Gi1/Beta1/Gamma2 3.9 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 7.17 2 No Yes 8 6 1 2
R:R:T113 R:R:Y34 3.75 2 No Yes 5 6 2 2
R:R:E293 R:R:K39 5.4 2 No No 4 8 1 1
L:L:?1 R:R:K39 11.94 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:M106 R:R:Y102 5.99 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 2 No Yes 6 6 1 1
R:R:I128 R:R:L105 7.14 0 No No 6 6 2 1
L:L:?1 R:R:L105 3.91 2 Yes No 0 6 0 1
R:R:M106 R:R:T109 3.01 0 No No 6 5 2 1
R:R:N108 R:R:R124 7.23 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 7.51 2 No No 4 5 1 1
L:L:?1 R:R:T109 6.24 2 Yes No 0 5 0 1
R:R:L116 R:R:T113 2.95 2 Yes No 6 5 2 2
R:R:R124 R:R:T113 3.88 2 Yes No 6 5 1 2
R:R:L116 R:R:W121 4.56 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 8 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 2 Yes Yes 4 9 1 2
R:R:L122 R:R:Y202 3.52 0 No Yes 5 4 2 1
R:R:Q125 R:R:R124 8.18 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 6.76 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 8.05 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 9.2 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 No Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 No Yes 7 8 2 2
R:R:M178 R:R:T133 6.02 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 13.91 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 18.08 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 2 No Yes 4 3 1 2
R:R:A199 R:R:Y202 4 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 8.94 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 5.54 0 No No 6 6 2 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 14.65 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.91
Average Nodes In Shell33.00
Average Hubs In Shell14.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU7 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - Gi1/Beta1/Gamma2 4.5 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 8.36 2 No Yes 8 6 1 1
R:R:L41 R:R:Y34 3.52 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 7.49 0 No Yes 5 6 2 1
R:R:P200 R:R:Y34 4.17 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K39 8.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:L105 R:R:Y102 3.52 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 5.86 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 0 No Yes 6 6 2 1
R:R:N108 R:R:R124 8.44 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 4.5 2 No No 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes No 0 5 0 1
R:R:R124 R:R:T113 3.88 2 Yes No 6 5 1 2
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 7 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 5.4 0 No Yes 6 9 2 2
R:R:L122 R:R:Y202 3.52 0 No Yes 5 4 2 1
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 6.86 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 6.76 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 3.35 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 8.05 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 8.05 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 No Yes 7 6 2 1
R:R:L132 R:R:W271 6.83 2 No Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 6.06 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 13.91 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 19.47 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No No 4 3 1 2
R:R:A199 R:R:Y202 4 0 No Yes 4 4 2 1
R:R:Y202 R:R:Y206 8.94 2 Yes Yes 4 7 1 2
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:L207 R:R:L278 5.54 2 No No 6 6 1 1
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 8.04 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 6.84 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 23.38 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 5.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 16.61 2 Yes No 0 6 0 1
R:R:L207 R:R:V282 2.98 2 No Yes 6 5 1 2
R:R:G110 R:R:T109 1.82 0 No No 5 5 2 1
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.18
Average Nodes In Shell36.00
Average Hubs In Shell14.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YU8 A Lipid Lysophospholipid (LPA) LPA1 Homo sapiens ONO-0740556 - Gi1/Beta1/Gamma2 5.6 2022-10-05 10.1038/s41467-022-33121-2

A 2D representation of the interactions of K6L in 7YU8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K39 R:R:Y34 11.94 2 No Yes 8 6 1 1
R:R:L41 R:R:Y34 3.52 0 No Yes 2 6 2 1
R:R:T113 R:R:Y34 7.49 2 No Yes 5 6 1 1
R:R:P200 R:R:Y34 4.17 0 No Yes 6 6 2 1
L:L:?1 R:R:Y34 3.31 2 Yes Yes 0 6 0 1
R:R:K39 R:R:S37 3.06 2 No No 8 7 1 2
R:R:P200 R:R:S37 3.56 0 No No 6 7 2 2
L:L:?1 R:R:K39 7.96 2 Yes No 0 8 0 1
R:R:K294 R:R:V52 13.66 2 No No 4 5 1 2
R:R:M106 R:R:Y102 5.99 0 No Yes 6 7 2 2
R:R:L297 R:R:Y102 9.38 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 6.07 2 No Yes 6 6 1 1
R:R:I128 R:R:L105 4.28 0 No No 6 6 2 1
L:L:?1 R:R:L105 2.93 2 Yes No 0 6 0 1
R:R:M106 R:R:T109 3.01 0 No Yes 6 5 2 1
R:R:N108 R:R:R124 7.23 0 No Yes 5 6 2 1
R:R:K294 R:R:T109 3 2 No Yes 4 5 1 1
L:L:?1 R:R:T109 5.2 2 Yes Yes 0 5 0 1
R:R:L116 R:R:T113 2.95 2 Yes No 6 5 2 1
L:L:?1 R:R:T113 3.12 2 Yes No 0 5 0 1
R:R:L116 R:R:W121 3.42 2 Yes Yes 6 9 2 2
R:R:L116 R:R:R124 4.86 2 Yes Yes 6 6 2 1
R:R:R124 R:R:W121 7 2 Yes Yes 6 9 1 2
R:R:Q125 R:R:W121 15.33 2 Yes Yes 4 9 1 2
R:R:P200 R:R:W121 5.4 0 No Yes 6 9 2 2
R:R:L122 R:R:Y202 4.69 0 No Yes 5 4 2 1
R:R:Q125 R:R:R124 9.35 2 Yes Yes 4 6 1 1
L:L:?1 R:R:R124 7.72 2 Yes Yes 0 6 0 1
R:R:Q125 R:R:Y202 5.64 2 Yes Yes 4 4 1 1
L:L:?1 R:R:Q125 7.52 2 Yes Yes 0 4 0 1
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:D129 R:R:Y202 8.05 2 Yes Yes 5 4 1 1
R:R:D129 R:R:Y206 10.34 2 Yes Yes 5 7 1 2
L:L:?1 R:R:D129 4.79 2 Yes Yes 0 5 0 1
R:R:L132 R:R:W210 3.42 2 Yes Yes 7 6 2 1
R:R:L132 R:R:W271 7.97 2 Yes Yes 7 8 2 2
R:R:M178 R:R:T133 4.52 2 Yes Yes 5 6 2 2
R:R:T133 R:R:W210 6.06 2 Yes Yes 6 6 2 1
R:R:M178 R:R:Y206 3.59 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 4.65 2 Yes Yes 5 6 2 1
R:R:P182 R:R:Y202 9.74 2 No Yes 6 4 2 1
R:R:P182 R:R:Y206 23.64 2 No Yes 6 7 2 2
R:R:E293 R:R:M198 14.89 0 No Yes 4 3 1 2
R:R:Y202 R:R:Y206 5.96 2 Yes Yes 4 7 1 2
R:R:L207 R:R:Y202 3.52 2 No Yes 6 4 1 1
L:L:?1 R:R:Y202 4.96 2 Yes Yes 0 4 0 1
R:R:W210 R:R:Y206 5.79 2 Yes Yes 6 7 1 2
R:R:L207 R:R:L278 5.54 2 No No 6 6 1 1
L:L:?1 R:R:L207 3.91 2 Yes No 0 6 0 1
R:R:W210 R:R:W271 4.69 2 Yes Yes 6 8 1 2
L:L:?1 R:R:W210 6.43 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 3.91 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 24.32 2 Yes No 0 4 0 1
L:L:?1 R:R:K294 6.97 2 Yes No 0 4 0 1
L:L:?1 R:R:L297 16.61 2 Yes No 0 6 0 1
L:L:?1 R:R:G274 2.41 2 Yes No 0 5 0 1
R:R:G110 R:R:T109 1.82 0 No Yes 5 5 2 1
R:R:N35 R:R:Y34 1.16 0 No Yes 7 6 2 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.00
Average Nodes In Shell38.00
Average Hubs In Shell17.00
Average Links In Shell58.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.33
Average Number Of Links With An Hub6.50
Average Interaction Strength8.14
Average Nodes In Shell36.33
Average Hubs In Shell15.33
Average Links In Shell52.33
Average Links Mediated by Hubs In Shell47.67

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)