psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	5.5	Yes	Yes	1	0	0
2	L:L:?1	R:R:T108	7.88	Yes	No	1	0	6
3	L:L:?1	R:R:Y112	12.54	Yes	Yes	1	0	5
4	L:L:?1	R:R:V166	4.78	Yes	Yes	1	0	5
5	L:L:?1	R:R:T175	4.73	Yes	No	0	0	5
6	L:L:G4	L:L:H2	3.18	No	Yes	0	0	0
7	L:L:H2	L:L:V5	13.84	Yes	Yes	1	0	0
8	L:L:H2	R:R:Y40	4.36	Yes	No	1	0	7
9	L:L:H2	R:R:W89	7.41	Yes	Yes	1	0	7
10	L:L:H2	R:R:F111	13.58	Yes	Yes	1	0	7
11	L:L:H2	R:R:E277	3.69	Yes	Yes	1	0	6
12	L:L:H2	R:R:F281	5.66	Yes	Yes	1	0	7
13	L:L:H3	R:R:K270	6.55	No	No	0	0	4
14	L:L:H3	R:R:L273	12.86	No	No	0	0	5
15	L:L:H3	R:R:E277	3.69	No	Yes	0	0	6
16	L:L:G4	R:R:I274	5.29	No	No	0	0	5
17	L:L:V5	R:R:W89	3.68	Yes	Yes	1	0	7
18	L:L:V5	R:R:Y92	6.31	Yes	Yes	1	0	6
19	L:L:V5	R:R:L93	5.96	Yes	No	0	0	6
20	L:L:T6	R:R:K270	6.01	No	No	0	0	4
21	L:L:K7	R:R:Y92	11.94	No	Yes	1	0	6
22	L:L:K7	R:R:Q172	5.42	No	Yes	1	0	3
23	L:L:C34	L:L:C8	7.28	No	No	9	0	0
24	L:L:N9	L:L:Q31	9.24	No	No	0	0	0
25	L:L:N9	R:R:L29	4.12	No	No	0	0	3
26	L:L:I10	L:L:I40	5.89	No	Yes	10	0	0
27	L:L:I10	R:R:P22	3.39	No	Yes	10	0	3
28	L:L:I10	R:R:V24	4.61	No	No	0	0	2
29	L:L:K36	L:L:T11	3	No	No	0	0	0
30	L:L:T11	R:R:F25	5.19	No	No	0	0	3
31	L:L:C12	L:L:C50	7.28	No	No	0	0	0
32	L:L:I19	L:L:T16	3.04	No	Yes	0	0	0
33	L:L:T16	R:R:D17	2.89	Yes	No	0	0	5
34	L:L:K18	L:L:W57	4.64	No	Yes	0	0	0
35	L:L:I19	L:L:P20	5.08	No	No	0	0	0
36	L:L:L23	L:L:P20	4.93	No	No	0	0	0
37	L:L:V21	L:L:W57	7.36	No	Yes	0	0	0
38	L:L:L24	L:L:Y27	12.89	No	Yes	2	0	0
39	L:L:L24	L:L:L41	8.3	No	No	2	0	0
40	L:L:I25	L:L:R44	5.01	No	No	0	0	0
41	L:L:H26	L:L:Q28	6.18	No	No	0	0	0
42	L:L:E42	L:L:H26	7.39	No	No	0	0	0
43	L:L:I39	L:L:Y27	16.92	No	Yes	2	0	0
44	L:L:L41	L:L:Y27	14.07	No	Yes	2	0	0
45	L:L:A51	L:L:Y27	4	No	Yes	0	0	0
46	L:L:V58	L:L:Y27	10.09	No	Yes	2	0	0
47	L:L:Q29	L:L:R37	3.5	No	Yes	0	0	0
48	L:L:N30	L:L:R37	12.05	No	Yes	0	0	0
49	L:L:A32	L:L:R37	4.15	No	Yes	0	0	0
50	L:L:A32	R:R:M174	3.22	No	Yes	0	0	4
51	L:L:S33	R:R:Q172	5.78	No	Yes	0	0	3
52	L:L:P53	L:L:R37	4.32	No	Yes	0	0	0
53	L:L:I39	L:L:V58	3.07	No	No	2	0	0
54	L:L:I40	L:L:L48	11.42	Yes	No	0	0	0
55	L:L:I40	R:R:P22	3.39	Yes	Yes	10	0	3
56	L:L:F49	L:L:L41	6.09	Yes	No	2	0	0
57	L:L:F49	L:L:T43	5.19	Yes	No	0	0	0
58	L:L:F49	L:L:R47	12.83	Yes	No	2	0	0
59	L:L:R47	R:R:Y16	8.23	No	Yes	2	0	5
60	L:L:R47	R:R:T21	5.17	No	No	0	0	3
61	L:L:F49	R:R:Y16	6.19	Yes	Yes	2	0	5
62	L:L:C50	R:R:P22	5.65	No	Yes	0	0	3
63	L:L:D52	L:L:P53	6.44	No	No	0	0	0
64	L:L:D52	L:L:K54	6.91	No	No	0	0	0
65	L:L:E55	L:L:W57	20.72	No	Yes	0	0	0
66	L:L:Q56	L:L:W57	8.76	No	Yes	0	0	0
67	L:L:D60	L:L:Q56	6.53	No	No	0	0	0
68	L:L:D60	L:L:K59	4.15	No	No	0	0	0
69	L:L:A61	L:L:H64	2.93	No	No	0	0	0
70	L:L:L65	L:L:M62	5.65	No	No	0	0	0
71	L:L:Q63	L:L:R67	12.85	No	No	0	0	0
72	L:L:H64	L:L:Q68	3.71	No	No	0	0	0
73	R:R:E18	R:R:Y16	6.73	No	Yes	0	3	5
74	R:R:D17	R:R:D19	5.32	No	No	0	5	4
75	R:R:C23	R:R:C263	7.28	No	No	0	8	6
76	R:R:T26	R:R:V24	3.17	No	No	0	4	2
77	R:R:F25	R:R:V28	5.24	No	No	0	3	4
78	R:R:F25	R:R:K270	4.96	No	No	0	3	4
79	R:R:N30	R:R:T26	4.39	No	No	0	4	4
80	R:R:D27	R:R:V28	4.38	No	No	0	3	4
81	R:R:D27	R:R:R267	9.53	No	No	0	3	3
82	R:R:R271	R:R:V28	5.23	No	No	0	2	4
83	R:R:S32	R:R:T36	4.8	No	Yes	8	3	5
84	R:R:I274	R:R:S32	7.74	No	No	8	5	3
85	R:R:K33	R:R:L93	9.87	No	No	0	4	6
86	R:R:L39	R:R:V35	2.98	No	No	0	5	5
87	R:R:L275	R:R:V35	2.98	No	No	0	5	5
88	R:R:L93	R:R:T36	2.95	No	Yes	0	6	5
89	R:R:I274	R:R:T36	3.04	No	Yes	8	5	5
90	R:R:L39	R:R:S278	7.51	No	No	0	5	5
91	R:R:L86	R:R:Y40	10.55	No	No	0	8	7
92	R:R:F281	R:R:Y40	7.22	Yes	No	1	7	7
93	R:R:F46	R:R:V42	3.93	No	No	0	5	5
94	R:R:L86	R:R:V43	2.98	No	No	0	8	7
95	R:R:C282	R:R:V43	3.42	No	No	0	6	7
96	R:R:C285	R:R:V43	8.54	No	No	0	7	7
97	R:R:F44	R:R:P87	11.56	No	No	0	6	9
98	R:R:F46	R:R:L45	6.09	No	No	0	5	5
99	R:R:C285	R:R:G47	3.92	No	No	0	7	8
100	R:R:D79	R:R:N51	6.73	Yes	No	0	9	9
101	R:R:N51	R:R:P288	8.15	No	No	0	9	9
102	R:R:F52	R:R:F56	21.43	No	No	0	2	3
103	R:R:I58	R:R:V54	3.07	No	Yes	0	6	9
104	R:R:A76	R:R:V54	3.39	No	Yes	0	8	9
105	R:R:V292	R:R:V54	8.02	No	Yes	0	7	9
106	R:R:F293	R:R:V54	3.93	Yes	Yes	0	7	9
107	R:R:I55	R:R:T59	7.6	No	No	0	7	2
108	R:R:F56	R:R:W60	17.04	No	No	0	3	4
109	R:R:F293	R:R:T57	3.89	Yes	No	5	7	6
110	R:R:L302	R:R:T57	4.42	No	No	5	6	6
111	R:R:L305	R:R:T57	2.95	Yes	No	5	4	6
112	R:R:I58	R:R:I64	2.94	No	No	11	6	6
113	R:R:I58	R:R:I73	10.3	No	No	11	6	5
114	R:R:R61	R:R:R63	3.2	No	No	0	5	6
115	R:R:E301	R:R:R61	8.14	No	No	5	4	5
116	R:R:L305	R:R:R61	7.29	Yes	No	5	4	5
117	R:R:Q65	R:R:R63	3.5	No	No	0	6	6
118	R:R:D69	R:R:I64	4.2	No	No	0	8	6
119	R:R:I64	R:R:I73	2.94	No	No	11	6	5
120	R:R:C66	R:R:D69	4.67	No	No	0	7	8
121	R:R:S67	R:R:Y71	5.09	Yes	Yes	6	6	7
122	R:R:D128	R:R:S67	4.42	No	Yes	6	8	6
123	R:R:R139	R:R:S67	3.95	Yes	Yes	6	7	6
124	R:R:A144	R:R:S67	3.42	No	Yes	0	8	6
125	R:R:D69	R:R:F298	3.58	No	Yes	0	8	8
126	R:R:N74	R:R:V70	2.96	Yes	Yes	1	9	6
127	R:R:V141	R:R:V70	4.81	No	Yes	0	4	6
128	R:R:A144	R:R:V70	5.09	No	Yes	0	8	6
129	R:R:S148	R:R:V70	3.23	No	Yes	1	7	6
130	R:R:E124	R:R:Y71	17.96	No	Yes	0	6	7
131	R:R:D128	R:R:Y71	8.05	No	Yes	6	8	7
132	R:R:F147	R:R:Y71	3.09	No	Yes	0	5	7
133	R:R:F72	R:R:I125	6.28	No	No	3	8	8
134	R:R:F72	R:R:V292	5.24	No	No	3	8	7
135	R:R:F298	R:R:F72	5.36	Yes	No	3	8	8
136	R:R:F121	R:R:N74	14.5	Yes	Yes	1	7	9
137	R:R:N74	R:R:S148	8.94	Yes	No	1	9	7
138	R:R:N74	R:R:W152	5.65	Yes	Yes	1	9	9
139	R:R:D79	R:R:L75	4.07	Yes	No	1	9	9
140	R:R:F121	R:R:L75	3.65	Yes	No	1	7	9
141	R:R:L75	R:R:N287	4.12	No	Yes	1	9	9
142	R:R:D79	R:R:S118	7.36	Yes	No	0	9	9
143	R:R:D79	R:R:N287	10.77	Yes	Yes	1	9	9
144	R:R:F111	R:R:F82	9.65	Yes	Yes	1	7	7
145	R:R:A114	R:R:F82	4.16	No	Yes	0	8	7
146	R:R:F281	R:R:F82	7.5	Yes	Yes	1	7	7
147	R:R:L107	R:R:T85	2.95	No	No	0	5	7
148	R:R:L86	R:R:P87	4.93	No	No	0	8	9
149	R:R:L107	R:R:L88	6.92	No	No	0	5	6
150	R:R:W89	R:R:Y92	7.72	Yes	Yes	1	7	6
151	R:R:L107	R:R:W89	21.64	No	Yes	0	5	7
152	R:R:T108	R:R:W89	6.06	No	Yes	1	6	7
153	R:R:F111	R:R:W89	4.01	Yes	Yes	1	7	7
154	R:R:Q91	R:R:S98	5.78	No	No	0	4	3
155	R:R:V102	R:R:Y92	7.57	Yes	Yes	0	3	6
156	R:R:Q172	R:R:Y92	4.51	Yes	Yes	1	3	6
157	R:R:C173	R:R:Y92	8.06	No	Yes	0	9	6
158	R:R:S101	R:R:S98	4.89	No	No	0	4	3
159	R:R:S98	R:R:V102	6.46	No	Yes	0	3	3
160	R:R:A100	R:R:K168	3.21	No	No	0	8	4
161	R:R:K168	R:R:V102	4.55	No	Yes	0	4	3
162	R:R:C104	R:R:K168	9.7	No	No	0	9	4
163	R:R:C104	R:R:C173	7.28	No	No	0	9	9
164	R:R:C110	R:R:L106	3.17	No	No	0	4	4
165	R:R:T108	R:R:V166	7.93	No	Yes	1	6	5
166	R:R:A109	R:R:F163	9.71	No	No	0	5	4
167	R:R:F111	R:R:Y112	10.32	Yes	Yes	1	7	5
168	R:R:F111	R:R:F281	5.36	Yes	Yes	1	7	7
169	R:R:F116	R:R:Y112	4.13	Yes	Yes	1	7	5
170	R:R:H162	R:R:Y112	18.51	Yes	Yes	1	4	5
171	R:R:V113	R:R:V156	6.41	No	No	0	5	3
172	R:R:M115	R:R:W241	4.65	No	Yes	0	8	8
173	R:R:F116	R:R:I158	10.05	Yes	Yes	0	7	5
174	R:R:F116	R:R:H162	3.39	Yes	Yes	1	7	4
175	R:R:A196	R:R:F116	4.16	No	Yes	0	6	7
176	R:R:A117	R:R:W152	6.48	No	Yes	0	7	9
177	R:R:L119	R:R:W241	9.11	No	Yes	0	7	8
178	R:R:C120	R:R:W151	6.53	No	Yes	0	5	6
179	R:R:F121	R:R:S148	3.96	Yes	No	1	7	7
180	R:R:F121	R:R:W151	5.01	Yes	Yes	0	7	6
181	R:R:F121	R:R:W152	11.02	Yes	Yes	1	7	9
182	R:R:I122	R:R:I204	2.94	No	No	0	8	7
183	R:R:I122	R:R:Y291	9.67	No	Yes	0	8	9
184	R:R:P200	R:R:T123	3.5	No	No	0	9	7
185	R:R:T123	R:R:V203	4.76	No	No	0	7	6
186	R:R:E124	R:R:W151	17.45	No	Yes	0	6	6
187	R:R:I125	R:R:R129	7.52	No	No	3	8	9
188	R:R:I125	R:R:Y291	6.04	No	Yes	3	8	9
189	R:R:A126	R:R:I204	3.25	No	No	0	9	7
190	R:R:A126	R:R:Y208	5.34	No	Yes	0	9	8
191	R:R:L127	R:R:V203	2.98	No	No	0	6	6
192	R:R:R129	R:R:Y208	9.26	No	Yes	3	9	8
193	R:R:R129	R:R:Y291	6.17	No	Yes	3	9	9
194	R:R:Y130	R:R:Y131	4.96	Yes	No	4	8	5
195	R:R:V134	R:R:Y130	11.36	Yes	Yes	4	7	8
196	R:R:Y130	R:R:Y135	7.94	Yes	Yes	4	8	6
197	R:R:Y130	R:R:Y206	8.94	Yes	No	4	8	3
198	R:R:C207	R:R:Y130	9.41	No	Yes	0	6	8
199	R:R:R210	R:R:Y130	9.26	Yes	Yes	4	3	8
200	R:R:Y131	R:R:Y135	2.98	No	Yes	4	5	6
201	R:R:R137	R:R:Y131	9.26	No	No	4	4	5
202	R:R:I133	R:R:I211	11.77	No	No	0	8	8
203	R:R:I133	R:R:I214	2.94	No	No	0	8	5
204	R:R:V134	R:R:Y135	5.05	Yes	Yes	4	7	6
205	R:R:R210	R:R:V134	5.23	Yes	Yes	4	3	7
206	R:R:I211	R:R:V134	3.07	No	Yes	0	8	7
207	R:R:I214	R:R:V134	4.61	No	Yes	0	5	7
208	R:R:R137	R:R:Y135	7.2	No	Yes	4	4	6
209	R:R:M136	R:R:Y138	5.99	No	No	0	4	4
210	R:R:P140	R:R:R139	4.32	No	Yes	6	6	7
211	R:R:Q143	R:R:R139	9.35	No	Yes	6	3	7
212	R:R:F147	R:R:R139	12.83	No	Yes	0	5	7
213	R:R:P140	R:R:Q143	14.21	No	No	6	6	3
214	R:R:F154	R:R:W151	6.01	No	Yes	0	4	6
215	R:R:I153	R:R:I157	2.94	No	No	0	3	3
216	R:R:F154	R:R:I158	3.77	No	Yes	0	4	5
217	R:R:E191	R:R:I158	5.47	No	Yes	0	2	5
218	R:R:I160	R:R:P161	3.39	No	No	0	5	9
219	R:R:F163	R:R:I160	6.28	No	No	0	4	5
220	R:R:E191	R:R:P161	7.86	No	No	0	2	9
221	R:R:H162	R:R:L188	11.57	Yes	No	0	4	5
222	R:R:E191	R:R:H162	7.39	No	Yes	0	2	4
223	R:R:H162	R:R:L192	5.14	Yes	No	1	4	5
224	R:R:M164	R:R:V165	3.04	No	Yes	7	4	5
225	R:R:M164	R:R:Y184	3.59	No	Yes	7	4	4
226	R:R:T175	R:R:V165	4.76	No	Yes	0	5	5
227	R:R:L180	R:R:V165	5.96	Yes	Yes	7	3	5
228	R:R:V165	R:R:Y184	6.31	Yes	Yes	7	5	4
229	R:R:C173	R:R:V166	3.42	No	Yes	0	9	5
230	R:R:D170	R:R:K169	4.15	No	No	0	1	3
231	R:R:K169	R:R:M174	8.64	No	Yes	0	3	4
232	R:R:N171	R:R:Q172	7.92	No	Yes	0	5	3
233	R:R:T175	R:R:Y177	12.48	No	No	0	5	5
234	R:R:D176	R:R:Y179	11.49	No	No	0	4	1
235	R:R:L180	R:R:Y177	3.52	Yes	No	0	3	5
236	R:R:P185	R:R:Y177	8.34	No	No	0	3	5
237	R:R:L180	R:R:Y184	11.72	Yes	Yes	7	3	4
238	R:R:S183	R:R:V182	3.23	No	No	0	1	1
239	R:R:I186	R:R:S183	4.64	No	No	0	3	1
240	R:R:P185	R:R:Y184	4.17	No	Yes	0	3	4
241	R:R:I187	R:R:Y184	3.63	No	Yes	0	3	4
242	R:R:L188	R:R:Y184	5.86	No	Yes	0	5	4
243	R:R:I186	R:R:L256	2.85	No	No	0	3	2
244	R:R:M193	R:R:N189	4.21	Yes	No	1	5	5
245	R:R:N189	R:R:T252	11.7	No	No	1	5	6
246	R:R:L192	R:R:Y244	4.69	No	Yes	1	5	6
247	R:R:L192	R:R:L248	4.15	No	No	1	5	5
248	R:R:H245	R:R:M193	3.94	Yes	Yes	1	8	5
249	R:R:L248	R:R:M193	4.24	No	Yes	1	5	5
250	R:R:F249	R:R:M193	3.73	No	Yes	0	5	5
251	R:R:M193	R:R:T252	3.01	Yes	No	1	5	6
252	R:R:L194	R:R:V198	4.47	No	No	0	4	5
253	R:R:G195	R:R:I199	3.53	No	No	0	3	5
254	R:R:F197	R:R:L201	3.65	Yes	Yes	1	9	6
255	R:R:F197	R:R:F237	5.36	Yes	Yes	1	9	9
256	R:R:F197	R:R:L242	3.65	Yes	No	0	9	5
257	R:R:F197	R:R:H245	20.36	Yes	Yes	1	9	8
258	R:R:I204	R:R:L201	2.85	No	Yes	0	7	6
259	R:R:F237	R:R:L201	6.09	Yes	Yes	1	9	6
260	R:R:I238	R:R:L201	5.71	No	Yes	0	5	6
261	R:R:R210	R:R:Y206	6.17	Yes	No	4	3	3
262	R:R:L230	R:R:Y208	8.21	Yes	Yes	0	7	8
263	R:R:Y208	R:R:Y291	2.98	Yes	Yes	3	8	9
264	R:R:R213	R:R:Y209	4.12	No	No	0	4	3
265	R:R:I211	R:R:L230	2.85	No	Yes	0	8	7
266	R:R:S212	R:R:V227	4.85	No	No	0	4	5
267	R:R:L230	R:R:S212	4.5	Yes	No	0	7	4
268	R:R:I226	R:R:V215	3.07	No	No	0	7	8
269	R:R:H222	R:R:R221	5.64	No	No	0	5	4
270	R:R:V229	R:R:V294	8.02	No	No	0	7	6
271	R:R:I231	R:R:L230	2.85	No	Yes	0	4	7
272	R:R:L290	R:R:V233	8.94	No	No	0	7	7
273	R:R:V233	R:R:Y291	5.05	No	Yes	0	7	9
274	R:R:L290	R:R:V236	4.47	No	No	0	7	6
275	R:R:F237	R:R:W241	8.02	Yes	Yes	1	9	8
276	R:R:F237	R:R:H283	5.66	Yes	Yes	1	9	9
277	R:R:I238	R:R:L242	2.85	No	No	0	5	5
278	R:R:F240	R:R:I239	3.77	Yes	No	0	7	5
279	R:R:F240	R:R:L279	6.09	Yes	No	0	7	7
280	R:R:F240	R:R:H283	7.92	Yes	Yes	0	7	9
281	R:R:W241	R:R:Y244	3.86	Yes	Yes	1	8	6
282	R:R:H245	R:R:W241	6.35	Yes	Yes	1	8	8
283	R:R:A280	R:R:W241	7.78	No	Yes	0	8	8
284	R:R:H283	R:R:W241	15.87	Yes	Yes	1	9	8
285	R:R:P243	R:R:T276	3.5	No	No	0	9	6
286	R:R:H245	R:R:Y244	9.8	Yes	Yes	1	8	6
287	R:R:L248	R:R:Y244	15.24	No	Yes	1	5	6
288	R:R:T276	R:R:Y244	4.99	No	Yes	0	6	6
289	R:R:E277	R:R:Y244	19.08	Yes	Yes	1	6	6
290	R:R:L273	R:R:T247	2.95	No	No	0	5	5
291	R:R:T247	R:R:T276	9.42	No	No	0	5	6
292	R:R:F249	R:R:L253	6.09	No	No	0	5	4
293	R:R:D251	R:R:L255	8.14	No	No	0	5	4
294	R:R:E266	R:R:K254	14.85	No	No	0	3	3
295	R:R:L256	R:R:W258	6.83	No	No	0	2	2
296	R:R:I259	R:R:S260	3.1	No	No	0	1	3
297	R:R:E266	R:R:F265	4.66	No	No	0	3	1
298	R:R:E277	R:R:F281	8.16	Yes	Yes	1	6	7
299	R:R:H283	R:R:N287	3.83	Yes	Yes	1	9	9
300	R:R:N287	R:R:P288	6.52	Yes	No	0	9	9
301	R:R:F298	R:R:V292	6.55	Yes	No	3	8	7
302	R:R:F293	R:R:L302	7.31	Yes	No	5	7	6
303	R:R:F298	R:R:K297	4.96	Yes	No	0	8	7
304	R:R:H303	R:R:R299	7.9	No	No	0	4	8
305	R:R:E301	R:R:L305	3.98	No	Yes	5	4	4
306	R:R:L194	R:R:M193	2.83	No	Yes	0	4	5
307	R:R:K33	R:R:L37	2.82	No	No	0	4	4
308	R:R:K254	R:R:L255	2.82	No	No	0	3	4
309	R:R:C284	R:R:F82	2.79	No	Yes	0	8	7
310	L:L:K14	R:R:D19	2.77	No	No	0	0	4
311	L:L:H64	L:L:V21	2.77	No	No	0	0	0
312	R:R:L37	R:R:L94	2.77	No	No	0	4	5
313	R:R:A159	R:R:F163	2.77	No	No	0	7	4
314	R:R:L242	R:R:L246	2.77	No	No	0	5	6
315	R:R:L80	R:R:N51	2.75	No	No	0	7	9
316	R:R:D176	R:R:L180	2.71	No	Yes	0	4	3
317	R:R:D251	R:R:L269	2.71	No	No	0	5	5
318	R:R:A132	R:R:Y138	2.67	No	No	0	7	4
319	R:R:E124	R:R:L127	2.65	No	No	0	6	6
320	R:R:F265	R:R:S262	2.64	No	No	0	1	6
321	R:R:A78	R:R:W152	2.59	No	Yes	0	8	9
322	R:R:H96	R:R:N171	2.55	No	No	0	5	5
323	R:R:V113	R:R:W152	2.45	No	Yes	0	5	9
324	R:R:F293	R:R:L53	2.44	Yes	No	0	7	6
325	R:R:F147	R:R:L146	2.44	No	No	0	5	2
326	R:R:F240	R:R:L286	2.44	Yes	No	0	7	7
327	R:R:F293	R:R:L289	2.44	Yes	No	0	7	6
328	R:R:T59	R:R:W60	2.43	No	No	0	2	4
329	R:R:L253	R:R:W258	2.28	No	No	0	4	2
330	R:R:C66	R:R:G68	1.96	No	No	0	7	7
331	R:R:G47	R:R:V83	1.84	No	No	0	8	6
332	R:R:G295	R:R:V294	1.84	No	No	0	8	6
333	R:R:A117	R:R:A155	1.79	No	No	0	7	7
334	R:R:P103	R:R:V102	1.77	No	Yes	0	5	3
335	R:R:G50	R:R:I49	1.76	No	No	0	7	4
336	R:R:G195	R:R:I158	1.76	No	Yes	0	3	5
337	L:L:G35	R:R:M174	1.75	No	Yes	0	0	4
338	R:R:P22	R:R:T21	1.75	Yes	No	0	3	3
339	L:L:C8	L:L:S33	1.72	No	No	0	0	0
340	R:R:C145	R:R:V141	1.71	No	No	0	4	4
341	L:L:C50	L:L:T16	1.69	No	Yes	0	0	0
342	L:L:I39	L:L:P53	1.69	No	No	0	0	0
343	R:R:C110	R:R:T85	1.69	No	No	0	4	7
344	L:L:T16	R:R:A20	1.68	Yes	No	0	0	4
345	R:R:M90	R:R:P87	1.68	No	No	0	7	9
346	R:R:A272	R:R:T247	1.68	No	No	0	4	5
347	R:R:K33	R:R:P34	1.67	No	No	0	4	3
348	R:R:L255	R:R:P185	1.64	No	No	0	4	3
349	R:R:S260	R:R:S262	1.63	No	No	0	3	6
350	L:L:C12	L:L:M15	1.62	No	No	0	0	0
351	R:R:S202	R:R:V203	1.62	No	No	0	3	6
352	R:R:S212	R:R:V215	1.62	No	No	0	4	8
353	L:L:A38	L:L:M15	1.61	No	No	0	0	0
354	R:R:S278	R:R:T36	1.6	No	Yes	0	5	5
355	R:R:V233	R:R:V234	1.6	No	No	0	7	8
356	R:R:C110	R:R:L81	1.59	No	No	0	4	6
357	R:R:T105	R:R:V166	1.59	No	Yes	0	8	5
358	R:R:C304	R:R:L305	1.59	No	Yes	0	4	4
359	L:L:A61	L:L:L24	1.58	No	No	0	0	0
360	L:L:C8	L:L:N30	1.57	No	No	9	0	0
361	L:L:C34	L:L:N30	1.57	No	No	9	0	0
362	R:R:I49	R:R:S48	1.55	No	No	0	4	5
363	R:R:I187	R:R:V190	1.54	No	No	0	3	4
364	L:L:K18	L:L:S17	1.53	No	No	0	0	0
365	R:R:K223	R:R:S220	1.53	No	No	0	7	4
366	R:R:I73	R:R:T59	1.52	No	No	0	5	2
367	R:R:F44	R:R:G41	1.51	No	No	0	6	5
368	R:R:F46	R:R:G47	1.51	No	No	0	5	8
369	R:R:M174	R:R:T167	1.51	Yes	No	0	4	4
370	R:R:L253	R:R:V250	1.49	No	No	0	4	5
371	R:R:L269	R:R:V250	1.49	No	No	0	5	5
372	R:R:E264	R:R:S268	1.44	No	No	0	4	3
373	R:R:I239	R:R:L235	1.43	No	No	0	5	5
374	L:L:Q45	L:L:T43	1.42	No	No	0	0	0
375	R:R:H222	R:R:S220	1.39	No	No	0	5	4
376	L:L:I40	L:L:Q28	1.37	Yes	No	0	0	0
377	R:R:L29	R:R:N30	1.37	No	No	0	3	4
378	L:L:D66	L:L:L65	1.36	No	No	0	0	0
379	L:L:H26	L:L:I25	1.33	No	No	0	0	0
380	R:R:D176	R:R:D178	1.33	No	No	0	4	6
381	R:R:H303	R:R:L306	1.29	No	No	0	4	6
382	R:R:S205	R:R:Y206	1.27	No	No	0	5	3
383	R:R:D95	R:R:H96	1.26	No	No	0	4	5
384	R:R:E264	R:R:R267	1.16	No	No	0	4	3
385	R:R:D15	R:R:Y16	1.15	No	Yes	0	4	5
386	R:R:H222	R:R:R225	1.13	No	No	0	5	7
387	R:R:R62	R:R:R63	1.07	No	No	0	5	6
388	R:R:R210	R:R:R213	1.07	Yes	No	0	3	4
389	R:R:R225	R:R:R228	1.07	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.086	5	1	0
2	L:L:H2	7.1525	8	1	0
3	L:L:V5	7.4475	4	1	0
4	L:L:T16	2.325	4	0	0
5	L:L:Y27	11.594	5	2	0
6	L:L:R37	6.005	4	0	0
7	L:L:I40	5.5175	4	10	0
8	L:L:F49	7.575	4	2	0
9	L:L:W57	10.37	4	0	0
10	R:R:Y16	5.575	4	2	5
11	R:R:P22	3.545	4	10	3
12	R:R:T36	3.0975	4	8	5
13	R:R:V54	4.6025	4	0	9
14	R:R:S67	4.22	4	6	6
15	R:R:V70	4.0225	4	1	6
16	R:R:Y71	8.5475	4	6	7
17	R:R:N74	8.0125	4	1	9
18	R:R:D79	7.2325	4	1	9
19	R:R:F82	6.025	4	1	7
20	R:R:W89	8.42	6	1	7
21	R:R:Y92	7.685	6	1	6
22	R:R:V102	5.0875	4	0	3
23	R:R:F111	8.584	5	1	7
24	R:R:Y112	11.375	4	1	5
25	R:R:F116	5.4325	4	1	7
26	R:R:F121	7.628	5	1	7
27	R:R:Y130	8.645	6	4	8
28	R:R:V134	5.864	5	4	7
29	R:R:Y135	5.7925	4	4	6
30	R:R:R139	7.6125	4	6	7
31	R:R:W151	8.75	4	0	6
32	R:R:W152	5.638	5	1	9
33	R:R:I158	5.2625	4	0	5
34	R:R:H162	9.2	5	1	4
35	R:R:V165	5.0175	4	7	5
36	R:R:V166	4.43	4	1	5
37	R:R:Q172	5.9075	4	1	3
38	R:R:M174	3.78	4	0	4
39	R:R:L180	5.9775	4	7	3
40	R:R:Y184	5.88	6	7	4
41	R:R:M193	3.66	6	1	5
42	R:R:F197	8.255	4	1	9
43	R:R:L201	4.575	4	1	6
44	R:R:Y208	6.4475	4	3	8
45	R:R:R210	5.4325	4	4	3
46	R:R:L230	4.6025	4	0	7
47	R:R:F237	6.2825	4	1	9
48	R:R:F240	5.055	4	0	7
49	R:R:W241	7.94857	7	1	8
50	R:R:Y244	9.61	6	1	6
51	R:R:H245	10.1125	4	1	8
52	R:R:E277	8.655	4	1	6
53	R:R:F281	6.78	5	1	7
54	R:R:H283	8.32	4	1	9
55	R:R:N287	6.31	4	1	9
56	R:R:Y291	5.982	5	3	9
57	R:R:F293	4.002	5	5	7
58	R:R:F298	5.1125	4	3	8
59	R:R:L305	3.9525	4	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	18.4528	5.5	Yes	Yes	1	0	0
2	L:L:H2	L:L:V5	48.8003	13.84	Yes	Yes	1	0	0
3	L:L:H2	R:R:Y40	14.9302	4.36	Yes	No	1	0	7
4	L:L:H2	R:R:W89	44.5944	7.41	Yes	Yes	1	0	7
5	R:R:F111	R:R:Y112	17.2069	10.32	Yes	Yes	1	7	5
6	L:L:H2	R:R:E277	92.5283	3.69	Yes	Yes	1	0	6
7	L:L:H3	R:R:E277	16.6406	3.69	No	Yes	0	0	6
8	L:L:H3	R:R:K270	13.454	6.55	No	No	0	0	4
9	L:L:V5	R:R:Y92	42.701	6.31	Yes	Yes	1	0	6
10	R:R:W89	R:R:Y92	54.9299	7.72	Yes	Yes	1	7	6
11	L:L:V5	R:R:L93	10.5865	5.96	Yes	No	0	0	6
12	R:R:Q172	R:R:Y92	90.3158	4.51	Yes	Yes	1	3	6
13	L:L:S33	R:R:Q172	85.8588	5.78	No	Yes	0	0	3
14	L:L:C8	L:L:S33	84.7016	1.72	No	No	0	0	0
15	L:L:C8	L:L:N30	82.2551	1.57	No	No	9	0	0
16	L:L:N30	L:L:R37	81.2074	12.05	No	Yes	0	0	0
17	L:L:P53	L:L:R37	71.7233	4.32	No	Yes	0	0	0
18	L:L:I39	L:L:P53	68.1045	1.69	No	No	0	0	0
19	L:L:I39	L:L:Y27	65.5711	16.92	No	Yes	2	0	0
20	L:L:L41	L:L:Y27	47.4091	14.07	No	Yes	2	0	0
21	L:L:F49	L:L:L41	46.9447	6.09	Yes	No	2	0	0
22	L:L:F49	L:L:R47	39.0803	12.83	Yes	No	2	0	0
23	L:L:R47	R:R:T21	37.9344	5.17	No	No	0	0	3
24	R:R:P22	R:R:T21	36.6319	1.75	Yes	No	0	3	3
25	R:R:F25	R:R:K270	11.0415	4.96	No	No	0	3	4
26	L:L:C50	R:R:P22	16.6141	5.65	No	Yes	0	0	3
27	L:L:C50	L:L:T16	11.1434	1.69	No	Yes	0	0	0
28	L:L:L24	L:L:Y27	15.8062	12.89	No	Yes	2	0	0
29	L:L:A61	L:L:L24	15.2606	1.58	No	No	0	0	0
30	L:L:A61	L:L:H64	13.892	2.93	No	No	0	0	0
31	L:L:H64	L:L:V21	11.1434	2.77	No	No	0	0	0
32	R:R:L86	R:R:Y40	21.1032	10.55	No	No	0	8	7
33	R:R:L86	R:R:V43	13.0614	2.98	No	No	0	8	7
34	R:R:E277	R:R:Y244	100	19.08	Yes	Yes	1	6	6
35	R:R:W241	R:R:Y244	54.1899	3.86	Yes	Yes	1	8	6
36	R:R:H283	R:R:W241	13.4276	15.87	Yes	Yes	1	9	8
37	R:R:H283	R:R:N287	18.3999	3.83	Yes	Yes	1	9	9
38	R:R:F237	R:R:W241	41.2606	8.02	Yes	Yes	1	9	8
39	R:R:F237	R:R:L201	49.0571	6.09	Yes	Yes	1	9	6
40	R:R:I204	R:R:L201	90.8519	2.85	No	Yes	0	7	6
41	R:R:I122	R:R:I204	55.0979	2.94	No	No	0	8	7
42	R:R:I122	R:R:Y291	53.9331	9.67	No	Yes	0	8	9
43	R:R:I125	R:R:Y291	48.2925	6.04	No	Yes	3	8	9
44	R:R:F72	R:R:I125	48.8041	6.28	No	No	3	8	8
45	R:R:F72	R:R:V292	30.7307	5.24	No	No	3	8	7
46	R:R:V292	R:R:V54	29.5113	8.02	No	Yes	0	7	9
47	R:R:I58	R:R:V54	10.0863	3.07	No	Yes	0	6	9
48	R:R:I73	R:R:T59	14.1846	1.52	No	No	0	5	2
49	R:R:H245	R:R:Y244	49.0816	9.8	Yes	Yes	1	8	6
50	R:R:F197	R:R:H245	45.8309	20.36	Yes	Yes	1	9	8
51	R:R:F197	R:R:L201	43.7978	3.65	Yes	Yes	1	9	6
52	R:R:F298	R:R:F72	16.7482	5.36	Yes	No	3	8	8
53	R:R:D69	R:R:F298	14.094	3.58	No	Yes	0	8	8
54	R:R:F293	R:R:V54	17.188	3.93	Yes	Yes	0	7	9
55	R:R:F293	R:R:T57	11.5021	3.89	Yes	No	5	7	6
56	R:R:L305	R:R:T57	10.0938	2.95	Yes	No	5	4	6
57	R:R:F116	R:R:Y112	17.9997	4.13	Yes	Yes	1	7	5
58	R:R:F116	R:R:I158	21.4147	10.05	Yes	Yes	0	7	5
59	R:R:F154	R:R:I158	22.4699	3.77	No	Yes	0	4	5
60	R:R:F154	R:R:W151	22.0037	6.01	No	Yes	0	4	6
61	R:R:E124	R:R:W151	16.5443	17.45	No	Yes	0	6	6
62	R:R:E124	R:R:Y71	10.9603	17.96	No	Yes	0	6	7
63	R:R:F121	R:R:W151	13.4125	5.01	Yes	Yes	0	7	6
64	R:R:L75	R:R:N287	12.8462	4.12	No	Yes	1	9	9
65	R:R:F121	R:R:L75	12.7556	3.65	Yes	No	1	7	9
66	R:R:A126	R:R:I204	34.6082	3.25	No	No	0	9	7
67	R:R:A126	R:R:Y208	33.519	5.34	No	Yes	0	9	8
68	R:R:L230	R:R:Y208	34.4307	8.21	Yes	Yes	0	7	8
69	R:R:I211	R:R:L230	26.0265	2.85	No	Yes	0	8	7
70	R:R:I211	R:R:V134	21.7432	3.07	No	Yes	0	8	7
71	R:R:H162	R:R:L188	10.8168	11.57	Yes	No	0	4	5
72	R:R:H162	R:R:L192	15.4456	5.14	Yes	No	1	4	5
73	L:L:?1	R:R:T175	19.9177	4.73	Yes	No	0	0	5
74	R:R:T175	R:R:Y177	11.6833	12.48	No	No	0	5	5
75	R:R:H245	R:R:M193	11.3303	3.94	Yes	Yes	1	8	5
76	R:R:F249	R:R:M193	12.446	3.73	No	Yes	0	5	5
77	R:R:F249	R:R:L253	11.1019	6.09	No	No	0	5	4
78	R:R:L255	R:R:P185	11.1566	1.64	No	No	0	4	3
79	R:R:L192	R:R:Y244	13.9788	4.69	No	Yes	1	5	6
80	R:R:F111	R:R:W89	11.2114	4.01	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T108	7.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y112	12.54	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V166	4.78	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T175	4.73	1	Yes	No	0	5	0	1
L:L:H2	R:R:Y40	4.36	1	Yes	No	0	7	0	1
L:L:H2	R:R:W89	7.41	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:F111	13.58	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:E277	3.69	1	Yes	Yes	0	6	0	1
L:L:H2	R:R:F281	5.66	1	Yes	Yes	0	7	0	1
L:L:H3	R:R:K270	6.55	0	No	No	0	4	0	1
L:L:H3	R:R:L273	12.86	0	No	No	0	5	0	1
L:L:H3	R:R:E277	3.69	0	No	Yes	0	6	0	1
L:L:G4	R:R:I274	5.29	0	No	No	0	5	0	1
L:L:V5	R:R:W89	3.68	1	Yes	Yes	0	7	0	1
L:L:V5	R:R:Y92	6.31	1	Yes	Yes	0	6	0	1
L:L:V5	R:R:L93	5.96	1	Yes	No	0	6	0	1
L:L:T6	R:R:K270	6.01	0	No	No	0	4	0	1
L:L:K7	R:R:Y92	11.94	1	No	Yes	0	6	0	1
L:L:K7	R:R:Q172	5.42	1	No	Yes	0	3	0	1
L:L:N9	R:R:L29	4.12	0	No	No	0	3	0	1
L:L:I10	R:R:P22	3.39	10	No	Yes	0	3	0	1
L:L:I10	R:R:V24	4.61	10	No	No	0	2	0	1
L:L:T11	R:R:F25	5.19	0	No	No	0	3	0	1
L:L:T16	R:R:D17	2.89	0	Yes	No	0	5	0	1
L:L:A32	R:R:M174	3.22	0	No	Yes	0	4	0	1
L:L:S33	R:R:Q172	5.78	0	No	Yes	0	3	0	1
L:L:I40	R:R:P22	3.39	10	Yes	Yes	0	3	0	1
L:L:R47	R:R:Y16	8.23	2	No	Yes	0	5	0	1
L:L:R47	R:R:T21	5.17	2	No	No	0	3	0	1
L:L:F49	R:R:Y16	6.19	2	Yes	Yes	0	5	0	1
L:L:C50	R:R:P22	5.65	0	No	Yes	0	3	0	1
R:R:E18	R:R:Y16	6.73	0	No	Yes	3	5	2	1
R:R:D17	R:R:D19	5.32	0	No	No	5	4	1	1
R:R:T26	R:R:V24	3.17	0	No	No	4	2	2	1
R:R:F25	R:R:V28	5.24	0	No	No	3	4	1	2
R:R:F25	R:R:K270	4.96	0	No	No	3	4	1	1
R:R:N30	R:R:T26	4.39	0	No	No	4	4	2	2
R:R:S32	R:R:T36	4.8	8	No	Yes	3	5	2	2
R:R:I274	R:R:S32	7.74	8	No	No	5	3	1	2
R:R:K33	R:R:L93	9.87	0	No	No	4	6	2	1
R:R:L93	R:R:T36	2.95	0	No	Yes	6	5	1	2
R:R:I274	R:R:T36	3.04	8	No	Yes	5	5	1	2
R:R:L86	R:R:Y40	10.55	0	No	No	8	7	2	1
R:R:F281	R:R:Y40	7.22	1	Yes	No	7	7	1	1
R:R:F111	R:R:F82	9.65	1	Yes	Yes	7	7	1	2
R:R:F281	R:R:F82	7.5	1	Yes	Yes	7	7	1	2
R:R:W89	R:R:Y92	7.72	1	Yes	Yes	7	6	1	1
R:R:L107	R:R:W89	21.64	0	No	Yes	5	7	2	1
R:R:T108	R:R:W89	6.06	1	No	Yes	6	7	1	1
R:R:F111	R:R:W89	4.01	1	Yes	Yes	7	7	1	1
R:R:V102	R:R:Y92	7.57	0	Yes	Yes	3	6	2	1
R:R:Q172	R:R:Y92	4.51	1	Yes	Yes	3	6	1	1
R:R:C173	R:R:Y92	8.06	0	No	Yes	9	6	2	1
R:R:T108	R:R:V166	7.93	1	No	Yes	6	5	1	1
R:R:F111	R:R:Y112	10.32	1	Yes	Yes	7	5	1	1
R:R:F111	R:R:F281	5.36	1	Yes	Yes	7	7	1	1
R:R:F116	R:R:Y112	4.13	1	Yes	Yes	7	5	2	1
R:R:H162	R:R:Y112	18.51	1	Yes	Yes	4	5	2	1
R:R:F116	R:R:H162	3.39	1	Yes	Yes	7	4	2	2
R:R:T175	R:R:V165	4.76	0	No	Yes	5	5	1	2
R:R:C173	R:R:V166	3.42	0	No	Yes	9	5	2	1
R:R:K169	R:R:M174	8.64	0	No	Yes	3	4	2	1
R:R:N171	R:R:Q172	7.92	0	No	Yes	5	3	2	1
R:R:T175	R:R:Y177	12.48	0	No	No	5	5	1	2
R:R:E277	R:R:Y244	19.08	1	Yes	Yes	6	6	1	2
R:R:L273	R:R:T247	2.95	0	No	No	5	5	1	2
R:R:E277	R:R:F281	8.16	1	Yes	Yes	6	7	1	1
L:L:K14	R:R:D19	2.77	0	No	No	0	4	0	1
L:L:G35	R:R:M174	1.75	0	No	Yes	0	4	0	1
R:R:P22	R:R:T21	1.75	10	Yes	No	3	3	1	1
L:L:T16	R:R:A20	1.68	0	Yes	No	0	4	0	1
R:R:T105	R:R:V166	1.59	0	No	Yes	8	5	2	1
R:R:M174	R:R:T167	1.51	0	Yes	No	4	4	1	2
R:R:L29	R:R:N30	1.37	0	No	No	3	4	1	2
R:R:D15	R:R:Y16	1.15	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RKM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	337
Number of Links	389
Number of Hubs	59
Number of Links mediated by Hubs	207
Number of Communities	11
Number of Nodes involved in Communities	87
Number of Links involved in Communities	121

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	113630
Length Of Smallest Path	3
Average Path Length	17.3237
Length of Longest Path	41
Minimum Path Strength	1.1
Average Path Strength	6.61394
Maximum Path Strength	19.235
Minimum Path Correlation	0.7
Average Path Correlation	0.951423
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	55.7263
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.2125
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • CX3C chemokine receptor binding • signaling receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • CCR chemokine receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • CXCR1 chemokine receptor binding • interleukin-8 receptor binding • CXCR chemokine receptor binding • cell adhesion molecule binding • integrin binding • chemoattractant activity • cell surface receptor signaling pathway • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • regulation of multicellular organismal development • regulation of developmental process • cellular developmental process • cell development • regulation of neurogenesis • regulation of cell differentiation • nervous system development • regulation of cell development • regulation of nervous system development • neurogenesis • cell differentiation • regulation of multicellular organismal process • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • positive regulation of locomotion • regulation of cell motility • regulation of microglial cell migration • glial cell migration • macrophage migration • regulation of glial cell migration • positive regulation of cell migration • regulation of macrophage migration • gliogenesis • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • positive regulation of microglial cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • cell motility • positive regulation of immune system process • locomotion • positive regulation of cellular process • positive regulation of macrophage migration • regulation of leukocyte migration • microglial cell migration • positive regulation of leukocyte migration • leukocyte migration • positive regulation of glial cell migration • immune system process • regulation of locomotion • mononuclear cell migration • cellular component organization • cellular component biogenesis • cellular component assembly • protein-containing complex organization • protein-containing complex assembly • integrin activation • cellular component organization or biogenesis • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • developmental maturation • generation of neurons • neuron differentiation • neuron remodeling • anatomical structure maturation • neuron development • neuron maturation • cell maturation • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • response to ischemia • cell chemotaxis • chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • taxis • granulocyte chemotaxis • leukocyte chemotaxis • positive chemotaxis • leukocyte migration involved in inflammatory response • autocrine signaling • regulation of neuron projection development • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • neuron projection development • positive regulation of neuron projection development • positive regulation of cell projection organization • plasma membrane bounded cell projection organization • regulation of cell projection organization • regulation of plasma membrane bounded cell projection organization • signal transduction in absence of ligand • cell death • extrinsic apoptotic signaling pathway • apoptotic signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • apoptotic process • programmed cell death • negative regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • eosinophil chemotaxis • eosinophil migration • lymphocyte chemotaxis • lymphocyte migration • wound healing • blood vessel morphogenesis • tube development • angiogenesis involved in wound healing • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • response to wounding • blood vessel development • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • cell activation • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • glial cell activation • neuroinflammatory response • cellular homeostasis • neuron cellular homeostasis • homeostatic process • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • regulation of intracellular signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of signaling • regulation of programmed cell death • negative regulation of cell communication • negative regulation of signal transduction in absence of ligand • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • negative regulation of response to stimulus • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of signal transduction • regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of apoptotic signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • immune response • regulation of macrophage activation • negative regulation of inflammatory response • regulation of leukocyte activation • regulation of cell activation • regulation of neuroinflammatory response • negative regulation of microglial cell activation • negative regulation of cell activation • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of microglial cell activation • negative regulation of neuroinflammatory response • negative regulation of leukocyte activation • negative regulation of macrophage activation • regulation of transforming growth factor beta production • transforming growth factor beta1 production • regulation of transforming growth factor beta1 production • positive regulation of transforming growth factor beta1 production • transforming growth factor beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of transforming growth factor beta production • positive regulation of cytokine production • response to chemokine • cellular response to chemokine • chemokine-mediated signaling pathway • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of lipopolysaccharide-mediated signaling pathway • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • cellular response to lipopolysaccharide • response to biotic stimulus • lipopolysaccharide-mediated signaling pathway • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to other organism • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to molecule of bacterial origin • negative regulation of interleukin-1 alpha production • regulation of interleukin-1 alpha production • interleukin-1 alpha production • cellular component disassembly • cell junction organization • cell junction disassembly • synapse pruning • synapse organization • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • regulation of actin filament organization • actin cytoskeleton organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of cellular component biogenesis • regulation of organelle organization • organelle organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • leukocyte adhesive activation • cellular extravasation • regulation of vasculature development • positive regulation of developmental process • regulation of anatomical structure morphogenesis • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • humoral immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • regulation of calcium-independent cell-cell adhesion • positive regulation of cell-cell adhesion • cell-cell adhesion • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • regulation of cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of calcium-independent cell-cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • macrophage chemotaxis • regulation of synaptic plasticity • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of biological quality • microglial cell proliferation • leukocyte proliferation • macrophage proliferation • glial cell proliferation • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of neuron migration • regulation of neuron migration • neuron migration • glutamate receptor signaling pathway • negative regulation of glutamate receptor signaling pathway • regulation of glutamate receptor signaling pathway • neuron apoptotic process • negative regulation of neuron apoptotic process • hippocampal neuron apoptotic process • regulation of hippocampal neuron apoptotic process • negative regulation of hippocampal neuron apoptotic process • regulation of neuron apoptotic process • neuroblast proliferation • positive regulation of nervous system development • regulation of neuroblast proliferation • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • neural precursor cell proliferation • perinuclear region of cytoplasm • somatodendritic compartment • cell body • neuronal cell body • cell surface • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • positive regulation of cytosolic calcium ion concentration • calcium-mediated signaling • symbiont-mediated perturbation of host cellular process • symbiont-mediated perturbation of host process • symbiont-mediated transformation of host cell • modulation of process of another organism • biological process involved in interaction with host • biological process involved in symbiotic interaction • host cell plasma membrane • host cellular component • host cell part • host cell membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	5-Pyrrolidone-2-carboxylic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P69332
Sequence	>7RKM_nogp_Chain_R D Y D E D A T P C V F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R R R I Q C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D H N S L A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y M R Y R P V K Q A C L F S I F W W I F A V I I A I P H F M V V T K K D N Q C M T D Y D Y L E V S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S Q S R H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K W I S S S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K F R Q E L H C L L A E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKF	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP	chim(NtGi1-G11)/β1/γ2	4	2022-01-26	10.1126/sciadv.abl5442
	7RKF (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP		4	2022-01-26	10.1126/sciadv.abl5442
	7RKN	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.6	2022-01-26	10.1126/sciadv.abl5442
	7RKN (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.6	2022-01-26	10.1126/sciadv.abl5442
	7RKM	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.5	2022-01-26	10.1126/sciadv.abl5442
	7RKM (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.5	2022-01-26	10.1126/sciadv.abl5442
	5WB2	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	CX3CL1.35	-	-	3.5	2018-06-13	10.7554/eLife.35850
	5WB1	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	-	-	-	3.51	2018-06-13	10.7554/eLife.35850
	4XT3	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	3.8	2015-03-04	10.1126/science.aaa5026
	4XT1	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	2.89	2015-03-04	10.1126/science.aaa5026

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7RKM_nogp.zip

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