psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	L:L:N9	23.41	Yes	Yes	1	0	0
2	H:H:?1	L:L:I10	2.56	Yes	Yes	1	0	0
3	H:H:?1	L:L:Q28	4.78	Yes	No	0	0	0
4	H:H:?1	L:L:Q31	5.97	Yes	No	1	0	0
5	H:H:?1	R:R:T26	11.9	Yes	No	0	0	4
6	L:L:?1	L:L:H2	4.13	Yes	No	2	0	0
7	L:L:?1	L:L:V5	4.78	Yes	No	0	0	0
8	L:L:?1	R:R:W89	6.09	Yes	Yes	2	0	7
9	L:L:?1	R:R:T108	3.15	Yes	No	0	0	6
10	L:L:H2	R:R:W89	4.23	No	Yes	2	0	7
11	L:L:H2	R:R:E277	2.46	No	Yes	2	0	6
12	L:L:H3	R:R:L273	5.14	No	No	0	0	5
13	L:L:G4	R:R:I274	3.53	No	No	0	0	5
14	L:L:K7	L:L:S33	3.06	No	Yes	0	0	0
15	L:L:K7	R:R:L93	2.82	No	No	0	0	6
16	L:L:C8	L:L:Q31	3.05	No	No	1	0	0
17	L:L:C8	L:L:S33	3.44	No	Yes	1	0	0
18	L:L:C34	L:L:C8	7.28	Yes	No	1	0	0
19	L:L:I10	L:L:N9	7.08	Yes	Yes	1	0	0
20	L:L:N9	R:R:V24	5.91	Yes	No	0	0	2
21	L:L:C12	L:L:I10	3.27	No	Yes	0	0	0
22	L:L:I10	L:L:N30	2.83	Yes	No	0	0	0
23	L:L:I10	L:L:I40	2.94	Yes	No	0	0	0
24	L:L:C12	L:L:C50	7.28	No	No	0	0	0
25	L:L:C12	R:R:P22	3.77	No	No	0	0	3
26	L:L:K14	R:R:A20	3.21	No	No	0	0	4
27	L:L:A51	L:L:T16	3.36	No	No	0	0	0
28	L:L:K18	L:L:S17	9.18	No	No	0	0	0
29	L:L:K18	L:L:W57	5.8	No	No	0	0	0
30	L:L:I19	L:L:P20	8.47	No	No	0	0	0
31	L:L:P20	R:R:D15	3.22	No	No	0	0	4
32	L:L:L23	L:L:R44	2.43	No	No	0	0	0
33	L:L:L23	L:L:Q45	6.65	No	Yes	0	0	0
34	L:L:L23	R:R:D15	4.07	No	No	0	0	4
35	L:L:L24	L:L:L41	4.15	No	No	0	0	0
36	L:L:H26	L:L:Q28	6.18	No	No	0	0	0
37	L:L:E42	L:L:H26	3.69	No	No	0	0	0
38	L:L:I39	L:L:Y27	8.46	Yes	Yes	3	0	0
39	L:L:V58	L:L:Y27	3.79	No	Yes	3	0	0
40	L:L:M62	L:L:Y27	3.59	No	Yes	0	0	0
41	L:L:I40	L:L:Q28	4.12	No	No	0	0	0
42	L:L:I39	L:L:Q29	2.74	Yes	No	0	0	0
43	L:L:A38	L:L:N30	3.13	No	No	0	0	0
44	L:L:Q31	L:L:S33	7.22	No	Yes	1	0	0
45	L:L:A32	R:R:D170	3.09	No	No	0	0	1
46	L:L:C34	L:L:S33	3.44	Yes	Yes	1	0	0
47	L:L:S33	R:R:Q172	5.78	Yes	No	0	0	3
48	L:L:C34	L:L:K36	3.23	Yes	No	0	0	0
49	L:L:R37	R:R:D178	5.96	No	No	0	0	6
50	L:L:I39	L:L:V58	3.07	Yes	No	3	0	0
51	L:L:F49	L:L:L41	3.65	No	No	0	0	0
52	L:L:E42	L:L:H46	2.46	No	No	0	0	0
53	L:L:Q45	L:L:T43	5.67	Yes	No	0	0	0
54	L:L:F49	L:L:T43	3.89	No	No	0	0	0
55	L:L:Q45	L:L:R47	3.5	Yes	No	0	0	0
56	L:L:Q45	R:R:E18	3.82	Yes	No	0	0	3
57	L:L:L48	R:R:P22	3.28	No	No	0	0	3
58	L:L:F49	R:R:E18	5.83	No	No	0	0	3
59	L:L:D52	L:L:P53	9.66	No	No	0	0	0
60	L:L:D52	L:L:K54	15.21	No	No	0	0	0
61	L:L:D60	L:L:Q56	3.92	No	No	0	0	0
62	L:L:K59	L:L:V58	4.55	No	No	0	0	0
63	L:L:D60	L:L:H64	17.65	No	No	0	0	0
64	L:L:M62	L:L:Q63	2.72	No	No	0	0	0
65	L:L:H64	L:L:R67	11.28	No	No	0	0	0
66	R:R:D15	R:R:Y16	9.2	No	No	0	4	5
67	R:R:C23	R:R:C263	7.28	No	No	0	8	6
68	R:R:F25	R:R:V28	3.93	Yes	No	0	3	4
69	R:R:N30	R:R:T26	5.85	No	No	0	4	4
70	R:R:D27	R:R:Q31	5.22	No	No	0	3	4
71	R:R:Q31	R:R:V28	5.73	No	No	4	4	4
72	R:R:R271	R:R:V28	3.92	No	No	4	2	4
73	R:R:Q31	R:R:R271	7.01	No	No	4	4	2
74	R:R:I274	R:R:S32	9.29	No	No	0	5	3
75	R:R:K33	R:R:P34	3.35	No	No	0	4	3
76	R:R:K33	R:R:L93	8.46	No	No	0	4	6
77	R:R:T36	R:R:Y40	3.75	No	Yes	0	5	7
78	R:R:S278	R:R:T36	6.4	No	No	0	5	5
79	R:R:L37	R:R:M90	7.07	No	No	0	4	7
80	R:R:F38	R:R:L39	3.65	No	No	0	5	5
81	R:R:F38	R:R:V42	2.62	No	No	0	5	5
82	R:R:L39	R:R:S278	6.01	No	No	0	5	5
83	R:R:L86	R:R:Y40	14.07	No	Yes	0	8	7
84	R:R:E277	R:R:Y40	3.37	Yes	Yes	2	6	7
85	R:R:F281	R:R:Y40	7.22	Yes	Yes	2	7	7
86	R:R:F44	R:R:V83	3.93	Yes	No	0	6	6
87	R:R:F44	R:R:L86	2.44	Yes	No	0	6	8
88	R:R:F44	R:R:P87	7.22	Yes	No	0	6	9
89	R:R:G47	R:R:V83	3.68	No	No	0	8	6
90	R:R:C285	R:R:G47	3.92	No	No	0	7	8
91	R:R:D79	R:R:N51	14.81	No	No	0	9	9
92	R:R:N51	R:R:P288	6.52	No	No	0	9	9
93	R:R:V292	R:R:V54	4.81	Yes	No	0	7	9
94	R:R:I55	R:R:I73	2.94	No	Yes	0	7	5
95	R:R:F56	R:R:W60	14.03	No	No	0	3	4
96	R:R:F56	R:R:L305	6.09	No	Yes	0	3	4
97	R:R:D69	R:R:I58	11.2	No	Yes	5	8	6
98	R:R:F72	R:R:I58	2.51	No	Yes	0	8	6
99	R:R:I58	R:R:I73	2.94	Yes	Yes	0	6	5
100	R:R:F298	R:R:I58	3.77	No	Yes	5	8	6
101	R:R:I73	R:R:T59	3.04	Yes	No	0	5	2
102	R:R:R61	R:R:W60	5	No	No	0	5	4
103	R:R:L305	R:R:R61	12.15	Yes	No	0	4	5
104	R:R:Q65	R:R:R62	3.5	No	No	0	6	5
105	R:R:E301	R:R:R62	5.82	Yes	No	0	4	5
106	R:R:D69	R:R:Q65	2.61	No	No	0	8	6
107	R:R:S67	R:R:Y71	2.54	Yes	Yes	6	6	7
108	R:R:R139	R:R:S67	2.64	Yes	Yes	0	7	6
109	R:R:A144	R:R:S67	3.42	No	Yes	6	8	6
110	R:R:D69	R:R:F298	3.58	No	No	5	8	8
111	R:R:E124	R:R:Y71	17.96	No	Yes	0	6	7
112	R:R:I125	R:R:Y71	2.42	No	Yes	0	8	7
113	R:R:A144	R:R:Y71	2.67	No	Yes	6	8	7
114	R:R:F72	R:R:I125	2.51	No	No	0	8	8
115	R:R:F72	R:R:V292	7.87	No	Yes	0	8	7
116	R:R:F121	R:R:N74	14.5	Yes	No	7	7	9
117	R:R:N74	R:R:S148	7.45	No	No	0	9	7
118	R:R:N74	R:R:W152	11.3	No	Yes	7	9	9
119	R:R:F121	R:R:L75	2.44	Yes	No	0	7	9
120	R:R:A78	R:R:W152	2.59	No	Yes	0	8	9
121	R:R:D79	R:R:V83	2.92	No	No	0	9	6
122	R:R:C284	R:R:D79	4.67	No	No	0	8	9
123	R:R:F111	R:R:F82	8.57	No	No	0	7	7
124	R:R:A114	R:R:F82	4.16	No	No	0	8	7
125	R:R:F82	R:R:M115	3.73	No	No	0	7	8
126	R:R:W89	R:R:Y92	8.68	Yes	No	0	7	6
127	R:R:Q91	R:R:S98	4.33	No	No	0	4	3
128	R:R:Q172	R:R:Y92	4.51	No	No	0	3	6
129	R:R:D95	R:R:L94	5.43	No	No	0	4	5
130	R:R:H96	R:R:Q172	2.47	No	No	0	5	3
131	R:R:L99	R:R:N171	5.49	No	No	0	7	5
132	R:R:S101	R:R:V102	3.23	No	No	0	4	3
133	R:R:P103	R:R:V102	3.53	No	No	0	5	3
134	R:R:P103	R:R:T167	5.25	No	Yes	8	5	4
135	R:R:K168	R:R:P103	5.02	No	No	8	4	5
136	R:R:C104	R:R:T167	3.38	No	Yes	0	9	4
137	R:R:C104	R:R:C173	7.28	No	No	0	9	9
138	R:R:T105	R:R:T167	3.14	No	Yes	0	8	4
139	R:R:A109	R:R:F163	4.16	No	No	0	5	4
140	R:R:F111	R:R:Y112	5.16	No	No	0	7	5
141	R:R:F111	R:R:F281	6.43	No	Yes	0	7	7
142	R:R:H162	R:R:Y112	11.98	Yes	No	0	4	5
143	R:R:V113	R:R:V156	3.21	No	No	0	5	3
144	R:R:F281	R:R:M115	2.49	Yes	No	0	7	8
145	R:R:F116	R:R:I158	6.28	No	No	0	7	5
146	R:R:A117	R:R:W152	7.78	No	Yes	0	7	9
147	R:R:L119	R:R:P200	8.21	Yes	No	0	7	9
148	R:R:F237	R:R:L119	2.44	No	Yes	0	9	7
149	R:R:C120	R:R:W151	5.22	No	No	0	5	6
150	R:R:C120	R:R:F154	2.79	No	No	0	5	4
151	R:R:F121	R:R:W151	5.01	Yes	No	0	7	6
152	R:R:F121	R:R:W152	5.01	Yes	Yes	7	7	9
153	R:R:I122	R:R:N287	2.83	No	No	0	8	9
154	R:R:I122	R:R:Y291	3.63	No	Yes	0	8	9
155	R:R:P200	R:R:T123	3.5	No	No	0	9	7
156	R:R:T123	R:R:V203	3.17	No	No	0	7	6
157	R:R:E124	R:R:W151	10.9	No	No	0	6	6
158	R:R:I125	R:R:Y291	3.63	No	Yes	0	8	9
159	R:R:A126	R:R:Y208	4	No	Yes	0	9	8
160	R:R:R129	R:R:Y208	4.12	No	Yes	0	9	8
161	R:R:Y130	R:R:Y131	5.96	Yes	No	0	8	5
162	R:R:V134	R:R:Y130	2.52	No	Yes	0	7	8
163	R:R:C207	R:R:Y130	6.72	No	Yes	0	6	8
164	R:R:I211	R:R:Y130	2.42	No	Yes	0	8	8
165	R:R:I133	R:R:I211	2.94	No	No	0	8	8
166	R:R:V134	R:R:Y135	5.05	No	No	0	7	6
167	R:R:R137	R:R:R139	6.4	No	Yes	0	4	7
168	R:R:F147	R:R:R139	4.28	No	Yes	0	5	7
169	R:R:A159	R:R:F163	2.77	No	No	0	7	4
170	R:R:I160	R:R:P161	3.39	No	No	0	5	9
171	R:R:F163	R:R:I160	7.54	No	No	0	4	5
172	R:R:H162	R:R:P161	3.05	Yes	No	9	4	9
173	R:R:L188	R:R:P161	3.28	No	No	9	5	9
174	R:R:H162	R:R:L188	2.57	Yes	No	9	4	5
175	R:R:E191	R:R:H162	4.92	No	Yes	0	2	4
176	R:R:M164	R:R:T175	3.01	No	No	0	4	5
177	R:R:M164	R:R:Y184	8.38	No	No	0	4	4
178	R:R:T175	R:R:V165	6.35	No	No	0	5	5
179	R:R:K169	R:R:V166	3.04	No	No	0	3	5
180	R:R:K168	R:R:T167	12.01	No	Yes	8	4	4
181	R:R:D170	R:R:K169	15.21	No	No	0	1	3
182	R:R:D176	R:R:D178	6.65	No	No	0	4	6
183	R:R:P185	R:R:Y177	2.78	No	No	0	3	5
184	R:R:L180	R:R:Y179	4.69	No	No	0	3	1
185	R:R:E181	R:R:S183	10.06	No	No	0	1	1
186	R:R:L188	R:R:Y184	3.52	No	No	0	5	4
187	R:R:I186	R:R:T252	3.04	No	Yes	0	3	6
188	R:R:L248	R:R:N189	9.61	No	No	0	5	5
189	R:R:N189	R:R:T252	4.39	No	Yes	0	5	6
190	R:R:E191	R:R:L192	2.65	No	No	0	2	5
191	R:R:H245	R:R:M193	2.63	No	No	0	8	5
192	R:R:F249	R:R:M193	6.22	No	No	10	5	5
193	R:R:M193	R:R:T252	3.01	No	Yes	10	5	6
194	R:R:L194	R:R:V198	2.98	No	No	0	4	5
195	R:R:F197	R:R:H245	19.23	No	No	0	9	8
196	R:R:I199	R:R:P200	3.39	No	No	0	5	9
197	R:R:F237	R:R:L201	2.44	No	No	0	9	6
198	R:R:I238	R:R:L201	2.85	No	No	0	5	6
199	R:R:I204	R:R:Y208	3.63	No	Yes	0	7	8
200	R:R:L230	R:R:Y208	8.21	No	Yes	0	7	8
201	R:R:R213	R:R:Y209	13.38	No	No	0	4	3
202	R:R:I214	R:R:R210	6.26	No	No	0	5	3
203	R:R:I226	R:R:V215	4.61	No	No	0	7	8
204	R:R:K223	R:R:S220	3.06	No	No	0	7	4
205	R:R:H222	R:R:I226	3.98	No	No	0	5	7
206	R:R:L290	R:R:V233	8.94	No	No	0	7	7
207	R:R:I239	R:R:L235	4.28	No	No	0	5	5
208	R:R:F240	R:R:V236	2.62	No	No	0	7	6
209	R:R:F237	R:R:H283	3.39	No	Yes	0	9	9
210	R:R:F240	R:R:H283	5.66	No	Yes	0	7	9
211	R:R:H245	R:R:W241	3.17	No	No	0	8	8
212	R:R:H283	R:R:W241	11.64	Yes	No	0	9	8
213	R:R:L242	R:R:P243	4.93	No	No	0	5	9
214	R:R:L242	R:R:L246	6.92	No	No	0	5	6
215	R:R:L248	R:R:Y244	3.52	No	Yes	0	5	6
216	R:R:T276	R:R:Y244	3.75	No	Yes	0	6	6
217	R:R:E277	R:R:Y244	6.73	Yes	Yes	0	6	6
218	R:R:T247	R:R:T276	4.71	No	No	0	5	6
219	R:R:F249	R:R:T252	5.19	No	Yes	10	5	6
220	R:R:F249	R:R:L253	7.31	No	No	0	5	4
221	R:R:D251	R:R:L255	6.79	No	No	0	5	4
222	R:R:D251	R:R:L269	2.71	No	No	0	5	5
223	R:R:I259	R:R:L253	4.28	No	No	0	1	4
224	R:R:E266	R:R:K254	13.5	No	No	0	3	3
225	R:R:L256	R:R:W258	11.39	No	No	0	2	2
226	R:R:E264	R:R:S262	10.06	No	No	0	4	6
227	R:R:F265	R:R:S262	3.96	No	No	0	1	6
228	R:R:E277	R:R:F281	9.33	Yes	Yes	2	6	7
229	R:R:H283	R:R:N287	2.55	Yes	No	0	9	9
230	R:R:L290	R:R:Y291	3.52	No	Yes	0	7	9
231	R:R:F293	R:R:V292	3.93	No	Yes	0	7	7
232	R:R:F298	R:R:V292	6.55	No	Yes	0	8	7
233	R:R:F293	R:R:L302	2.44	No	No	0	7	6
234	R:R:R299	R:R:T296	3.88	No	No	0	8	5
235	R:R:E301	R:R:K297	4.05	Yes	No	0	4	7
236	R:R:F309	R:R:L305	2.44	No	Yes	0	4	4
237	R:R:F309	R:R:R310	5.34	No	No	0	4	3
238	R:R:M174	R:R:Y177	2.39	No	No	0	4	5
239	R:R:D128	R:R:R139	2.38	No	Yes	0	8	7
240	L:L:L65	L:L:Y27	2.34	No	Yes	0	0	0
241	R:R:F147	R:R:Q143	2.34	No	No	0	5	3
242	R:R:D17	R:R:Y16	2.3	No	No	0	5	5
243	R:R:L107	R:R:W89	2.28	No	Yes	0	5	7
244	R:R:H303	R:R:R299	2.26	No	No	0	4	8
245	R:R:E181	R:R:Y179	2.24	No	No	0	1	1
246	L:L:Q56	L:L:W57	2.19	No	No	0	0	0
247	R:R:R129	R:R:Y291	2.06	No	Yes	0	9	9
248	R:R:R210	R:R:Y130	2.06	No	Yes	0	3	8
249	R:R:G68	R:R:S67	1.86	No	Yes	0	7	6
250	R:R:G224	R:R:V227	1.84	No	No	0	6	5
251	R:R:A117	R:R:A155	1.79	No	No	0	7	7
252	R:R:G50	R:R:I49	1.76	No	No	0	7	4
253	R:R:G195	R:R:I199	1.76	No	No	0	3	5
254	R:R:P22	R:R:T21	1.75	No	No	0	3	3
255	R:R:P243	R:R:T276	1.75	No	No	0	9	6
256	R:R:G224	R:R:K223	1.74	No	No	0	6	7
257	R:R:C284	R:R:V43	1.71	No	No	0	8	7
258	R:R:C285	R:R:V43	1.71	No	No	0	7	7
259	R:R:G195	R:R:L194	1.71	No	No	0	3	4
260	R:R:C207	R:R:V203	1.71	No	No	0	6	6
261	L:L:?1	R:R:C173	1.7	Yes	No	0	0	9
262	R:R:A76	R:R:V54	1.7	No	No	0	8	9
263	R:R:A155	R:R:V113	1.7	No	No	0	7	5
264	R:R:C110	R:R:T85	1.69	No	No	0	4	7
265	L:L:C34	R:R:M174	1.62	Yes	No	0	0	4
266	L:L:A51	L:L:I39	1.62	No	Yes	0	0	0
267	R:R:S202	R:R:V203	1.62	No	No	0	3	6
268	R:R:S212	R:R:V227	1.62	No	No	0	4	5
269	R:R:V141	R:R:V70	1.6	No	No	0	4	6
270	R:R:V229	R:R:V233	1.6	No	No	0	7	7
271	R:R:C110	R:R:L81	1.59	No	No	0	4	6
272	R:R:C207	R:R:L127	1.59	No	No	0	6	6
273	L:L:A61	L:L:L24	1.58	No	No	0	0	0
274	L:L:A51	L:L:L41	1.58	No	No	0	0	0
275	R:R:A114	R:R:L81	1.58	No	No	0	8	6
276	R:R:A196	R:R:L119	1.58	No	Yes	0	6	7
277	R:R:I149	R:R:S148	1.55	No	No	0	4	7
278	R:R:I186	R:R:S183	1.55	No	No	0	3	1
279	R:R:I64	R:R:V70	1.54	No	No	0	6	6
280	R:R:I187	R:R:V190	1.54	No	No	0	3	4
281	R:R:I204	R:R:V234	1.54	No	No	0	7	8
282	R:R:I231	R:R:V227	1.54	No	No	0	4	5
283	L:L:K14	L:L:S13	1.53	No	No	0	0	0
284	R:R:C66	R:R:Q65	1.53	No	No	0	7	6
285	R:R:K142	R:R:V141	1.52	No	No	0	3	4
286	R:R:K223	R:R:V215	1.52	No	No	0	7	8
287	R:R:C263	R:R:E264	1.52	No	No	0	6	4
288	R:R:C304	R:R:E301	1.52	No	Yes	0	4	4
289	R:R:L119	R:R:S118	1.5	Yes	No	0	7	9
290	R:R:G224	R:R:R228	1.5	No	No	0	6	6
291	R:R:L275	R:R:V35	1.49	No	No	0	5	5
292	R:R:L106	R:R:V102	1.49	No	No	0	4	3
293	R:R:L286	R:R:V236	1.49	No	No	0	7	6
294	R:R:L305	R:R:T57	1.47	Yes	No	0	4	6
295	R:R:I64	R:R:I73	1.47	No	Yes	0	6	5
296	R:R:I149	R:R:I153	1.47	No	No	0	4	3
297	R:R:I238	R:R:I239	1.47	No	No	0	5	5
298	L:L:D60	L:L:V21	1.46	No	No	0	0	0
299	R:R:D176	R:R:V166	1.46	No	No	0	4	5
300	R:R:G41	R:R:Y40	1.45	No	Yes	0	5	7
301	R:R:P140	R:R:R139	1.44	No	Yes	0	6	7
302	R:R:E181	R:R:V182	1.43	No	No	0	1	1
303	R:R:I186	R:R:L255	1.43	No	No	0	3	4
304	R:R:K33	R:R:L29	1.41	No	No	0	4	3
305	R:R:E301	R:R:T57	1.41	Yes	No	0	4	6
306	R:R:L94	R:R:M90	1.41	No	No	0	5	7
307	R:R:K168	R:R:L99	1.41	No	No	0	4	7
308	R:R:C285	R:R:F46	1.4	No	No	0	7	5
309	L:L:D52	L:L:M15	1.39	No	No	0	0	0
310	R:R:A155	R:R:F116	1.39	No	No	0	7	7
311	R:R:L37	R:R:L93	1.38	No	No	0	4	6
312	R:R:L302	R:R:L53	1.38	No	No	0	6	6
313	R:R:L107	R:R:L88	1.38	No	No	0	5	6
314	L:L:E42	L:L:I25	1.37	No	No	0	0	0
315	L:L:K59	L:L:Q56	1.36	No	No	0	0	0
316	R:R:K297	R:R:Q300	1.36	No	No	0	7	5
317	R:R:L88	R:R:Q91	1.33	No	No	0	6	4
318	R:R:A280	R:R:Y244	1.33	No	Yes	0	8	6
319	R:R:E266	R:R:L269	1.33	No	No	0	3	5
320	R:R:F44	R:R:S48	1.32	Yes	No	0	6	5
321	R:R:R63	R:R:T59	1.29	No	No	0	6	2
322	R:R:H303	R:R:L302	1.29	No	No	0	4	6
323	R:R:H96	R:R:N97	1.28	No	No	0	5	9
324	R:R:F52	R:R:I55	1.26	No	No	0	2	7
325	R:R:F25	R:R:K270	1.24	Yes	No	0	3	4
326	R:R:F46	R:R:L45	1.22	No	No	0	5	5
327	R:R:F293	R:R:L289	1.22	No	No	0	7	6
328	L:L:N9	R:R:F25	1.21	Yes	Yes	0	0	3
329	R:R:I187	R:R:Y184	1.21	No	No	0	3	4
330	R:R:M136	R:R:Y138	1.2	No	No	0	4	4
331	R:R:I259	R:R:W258	1.17	No	No	0	1	2
332	R:R:E308	R:R:R61	1.16	No	No	0	4	5
333	R:R:H222	R:R:R225	1.13	No	No	0	5	7
334	L:L:H3	R:R:Y244	1.09	No	Yes	0	0	6
335	R:R:F25	R:R:R267	1.07	Yes	No	0	3	3
336	R:R:R210	R:R:R213	1.07	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	H:H:?1	9.724	5	1	0
2	L:L:?1	3.97	5	2	0
3	L:L:N9	9.4025	4	1	0
4	L:L:I10	3.736	5	1	0
5	L:L:Y27	4.545	4	3	0
6	L:L:S33	4.588	5	1	0
7	L:L:C34	3.8925	4	1	0
8	L:L:I39	3.9725	4	3	0
9	L:L:Q45	4.91	4	0	0
10	R:R:F25	1.8625	4	0	3
11	R:R:Y40	5.972	5	2	7
12	R:R:F44	3.7275	4	0	6
13	R:R:I58	5.105	4	5	6
14	R:R:S67	2.615	4	6	6
15	R:R:Y71	6.3975	4	6	7
16	R:R:I73	2.5975	4	0	5
17	R:R:W89	5.32	4	2	7
18	R:R:L119	3.4325	4	0	7
19	R:R:F121	6.74	4	7	7
20	R:R:Y130	3.936	5	0	8
21	R:R:R139	3.428	5	0	7
22	R:R:W152	6.67	4	7	9
23	R:R:H162	5.63	4	9	4
24	R:R:T167	5.945	4	8	4
25	R:R:Y208	4.99	4	0	8
26	R:R:Y244	3.284	5	0	6
27	R:R:T252	3.9075	4	10	6
28	R:R:E277	5.4725	4	2	6
29	R:R:F281	6.3675	4	2	7
30	R:R:H283	5.81	4	0	9
31	R:R:Y291	3.21	4	0	9
32	R:R:V292	5.79	4	0	7
33	R:R:E301	3.2	4	0	4
34	R:R:L305	5.5375	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	L:L:Q31	37.3725	5.97	Yes	No	1	0	0
2	L:L:Q31	L:L:S33	37.6403	7.22	No	Yes	1	0	0
3	L:L:S33	R:R:Q172	55.3922	5.78	Yes	No	0	0	3
4	R:R:Q172	R:R:Y92	58.3661	4.51	No	No	0	3	6
5	R:R:W89	R:R:Y92	59.3346	8.68	Yes	No	0	7	6
6	L:L:H2	R:R:W89	59.779	4.23	No	Yes	2	0	7
7	L:L:H2	R:R:E277	76.3117	2.46	No	Yes	2	0	6
8	R:R:E277	R:R:Y244	99.1227	6.73	Yes	Yes	0	6	6
9	L:L:K7	L:L:S33	13.1203	3.06	No	Yes	0	0	0
10	L:L:K7	R:R:L93	11.7074	2.82	No	No	0	0	6
11	H:H:?1	L:L:N9	12.8639	23.41	Yes	Yes	1	0	0
12	H:H:?1	L:L:I10	12.8354	2.56	Yes	Yes	1	0	0
13	L:L:N9	R:R:F25	10.4427	1.21	Yes	Yes	0	0	3
14	R:R:E277	R:R:Y40	26.8159	3.37	Yes	Yes	2	6	7
15	R:R:L86	R:R:Y40	21.3582	14.07	No	Yes	0	8	7
16	R:R:E277	R:R:F281	35.3501	9.33	Yes	Yes	2	6	7
17	R:R:F44	R:R:L86	20.0137	2.44	Yes	No	0	6	8
18	R:R:F44	R:R:V83	15.9118	3.93	Yes	No	0	6	6
19	R:R:L248	R:R:Y244	99.943	3.52	No	Yes	0	5	6
20	R:R:L248	R:R:N189	99.9772	9.61	No	No	0	5	5
21	R:R:N189	R:R:T252	100	4.39	No	Yes	0	5	6
22	R:R:M193	R:R:T252	95.3113	3.01	No	Yes	10	5	6
23	R:R:H245	R:R:M193	98.4618	2.63	No	No	0	8	5
24	R:R:H245	R:R:W241	98.063	3.17	No	No	0	8	8
25	R:R:H283	R:R:W241	97.8465	11.64	Yes	No	0	9	8
26	R:R:H283	R:R:N287	84.9029	2.55	Yes	No	0	9	9
27	R:R:I122	R:R:N287	84.3104	2.83	No	No	0	8	9
28	R:R:I122	R:R:Y291	83.7065	3.63	No	Yes	0	8	9
29	R:R:I125	R:R:Y291	77.041	3.63	No	Yes	0	8	9
30	R:R:F72	R:R:I125	51.2676	2.51	No	No	0	8	8
31	R:R:F72	R:R:V292	14.7268	7.87	No	Yes	0	8	7
32	R:R:F72	R:R:I58	36.6148	2.51	No	Yes	0	8	6
33	R:R:I58	R:R:I73	13.5817	2.94	Yes	Yes	0	6	5
34	R:R:D69	R:R:I58	22.8508	11.2	No	Yes	5	8	6
35	R:R:D69	R:R:Q65	22.6001	2.61	No	No	0	8	6
36	R:R:Q65	R:R:R62	19.9339	3.5	No	No	0	6	5
37	R:R:E301	R:R:R62	18.5837	5.82	Yes	No	0	4	5
38	R:R:E301	R:R:T57	13.069	1.41	Yes	No	0	4	6
39	R:R:L305	R:R:T57	11.6618	1.47	Yes	No	0	4	6
40	R:R:I125	R:R:Y71	37.7998	2.42	No	Yes	0	8	7
41	R:R:S67	R:R:Y71	11.6618	2.54	Yes	Yes	6	6	7
42	R:R:E124	R:R:Y71	25.3233	17.96	No	Yes	0	6	7
43	R:R:E124	R:R:W151	24.013	10.9	No	No	0	6	6
44	R:R:F121	R:R:W151	20.0137	5.01	Yes	No	0	7	6
45	R:R:F121	R:R:W152	11.5251	5.01	Yes	Yes	7	7	9
46	R:R:F111	R:R:F281	29.7955	6.43	No	Yes	0	7	7
47	R:R:A114	R:R:F82	11.2288	4.16	No	No	0	8	7
48	L:L:?1	R:R:C173	15.9118	1.7	Yes	No	0	0	9
49	R:R:C104	R:R:C173	14.5217	7.28	No	No	0	9	9
50	R:R:C104	R:R:T167	13.1203	3.38	No	Yes	0	9	4
51	R:R:F111	R:R:Y112	22.3267	5.16	No	No	0	7	5
52	R:R:H162	R:R:Y112	21.0163	11.98	Yes	No	0	4	5
53	R:R:F237	R:R:H283	37.7998	3.39	No	Yes	0	9	9
54	R:R:F237	R:R:L119	31.704	2.44	No	Yes	0	9	7
55	R:R:L119	R:R:P200	27.9098	8.21	Yes	No	0	7	9
56	R:R:P200	R:R:T123	21.3582	3.5	No	No	0	9	7
57	R:R:T123	R:R:V203	20.0137	3.17	No	No	0	7	6
58	R:R:C207	R:R:V203	17.2905	1.71	No	No	0	6	6
59	R:R:C207	R:R:Y130	14.5217	6.72	No	Yes	0	6	8
60	R:R:I186	R:R:T252	15.9118	3.04	No	Yes	0	3	6
61	R:R:F293	R:R:V292	10.6421	3.93	No	Yes	0	7	7
62	L:L:?1	L:L:H2	15.7865	4.13	Yes	No	2	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	L:L:N9	23.41	1	Yes	Yes	0	0	1	0
H:H:?1	L:L:I10	2.56	1	Yes	Yes	0	0	1	0
H:H:?1	L:L:Q28	4.78	1	Yes	No	0	0	1	0
H:H:?1	L:L:Q31	5.97	1	Yes	No	0	0	1	0
H:H:?1	R:R:T26	11.9	1	Yes	No	0	4	1	2
L:L:?1	R:R:W89	6.09	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:T108	3.15	2	Yes	No	0	6	0	1
L:L:H2	R:R:W89	4.23	2	No	Yes	0	7	0	1
L:L:H2	R:R:E277	2.46	2	No	Yes	0	6	0	1
L:L:H3	R:R:L273	5.14	0	No	No	0	5	0	1
L:L:G4	R:R:I274	3.53	0	No	No	0	5	0	1
L:L:K7	R:R:L93	2.82	0	No	No	0	6	0	1
L:L:N9	R:R:V24	5.91	1	Yes	No	0	2	0	1
L:L:C12	R:R:P22	3.77	0	No	No	0	3	0	1
L:L:K14	R:R:A20	3.21	0	No	No	0	4	0	1
L:L:P20	R:R:D15	3.22	0	No	No	0	4	0	1
L:L:L23	R:R:D15	4.07	0	No	No	0	4	0	1
L:L:A32	R:R:D170	3.09	0	No	No	0	1	0	1
L:L:S33	R:R:Q172	5.78	1	Yes	No	0	3	0	1
L:L:R37	R:R:D178	5.96	0	No	No	0	6	0	1
L:L:Q45	R:R:E18	3.82	0	Yes	No	0	3	0	1
L:L:L48	R:R:P22	3.28	0	No	No	0	3	0	1
L:L:F49	R:R:E18	5.83	0	No	No	0	3	0	1
R:R:D15	R:R:Y16	9.2	0	No	No	4	5	1	2
R:R:F25	R:R:V28	3.93	0	Yes	No	3	4	1	2
R:R:I274	R:R:S32	9.29	0	No	No	5	3	1	2
R:R:K33	R:R:L93	8.46	0	No	No	4	6	2	1
R:R:E277	R:R:Y40	3.37	2	Yes	Yes	6	7	1	2
R:R:F281	R:R:Y40	7.22	2	Yes	Yes	7	7	2	2
R:R:W89	R:R:Y92	8.68	2	Yes	No	7	6	1	2
R:R:Q172	R:R:Y92	4.51	0	No	No	3	6	1	2
R:R:H96	R:R:Q172	2.47	0	No	No	5	3	2	1
R:R:C104	R:R:C173	7.28	0	No	No	9	9	2	1
R:R:D170	R:R:K169	15.21	0	No	No	1	3	1	2
R:R:D176	R:R:D178	6.65	0	No	No	4	6	2	1
R:R:L248	R:R:Y244	3.52	0	No	Yes	5	6	2	1
R:R:T276	R:R:Y244	3.75	0	No	Yes	6	6	2	1
R:R:E277	R:R:Y244	6.73	2	Yes	Yes	6	6	1	1
R:R:E277	R:R:F281	9.33	2	Yes	Yes	6	7	1	2
R:R:M174	R:R:Y177	2.39	0	No	No	4	5	1	2
R:R:L107	R:R:W89	2.28	0	No	Yes	5	7	2	1
R:R:P22	R:R:T21	1.75	0	No	No	3	3	1	2
L:L:?1	R:R:C173	1.7	2	Yes	No	0	9	0	1
L:L:C34	R:R:M174	1.62	1	Yes	No	0	4	0	1
R:R:L37	R:R:L93	1.38	0	No	No	4	6	2	1
R:R:A280	R:R:Y244	1.33	0	No	Yes	8	6	2	1
R:R:F25	R:R:K270	1.24	0	Yes	No	3	4	1	2
L:L:N9	R:R:F25	1.21	1	Yes	Yes	0	3	0	1
L:L:H3	R:R:Y244	1.09	0	No	Yes	0	6	0	1
R:R:F25	R:R:R267	1.07	0	Yes	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RKF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	328
Number of Links	336
Number of Hubs	34
Number of Links mediated by Hubs	129
Number of Communities	10
Number of Nodes involved in Communities	37
Number of Links involved in Communities	40

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	35582
Length Of Smallest Path	3
Average Path Length	16.1575
Length of Longest Path	35
Minimum Path Strength	1.14
Average Path Strength	4.85965
Maximum Path Strength	17.655
Minimum Path Correlation	0.86
Average Path Correlation	0.98432
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	16.6667
Average % Of Corr. Nodes	88.277
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.3399
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	GDP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GDP
Name	Guanosine-5'-Diphosphate
Synonyms	Guanosine-5'-Diphosphate
Identifier
Formula	C10 H15 N5 O11 P2
Molecular Weight	443.201
SMILES
PubChem	8977
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	4
Total Bonds	45
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P69332
Sequence	>7RKF_nogp_Chain_R D Y D E D A T P C V F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R R R I Q C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D H N S L A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y M R Y R P V K Q A C L F S I F W W I F A V I I A I P H F M V V T K K D N Q C M T D Y D Y L E V S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S Q S R H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K W I S S S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K F R Q E L H C L L A E F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKF	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP	chim(NtGi1-G11)/β1/γ2	4	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKF (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP		4	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKM	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.5	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKM (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.5	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKN	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.6	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKN (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.6	2022-01-26	doi.org/10.1126/sciadv.abl5442
	4XT1	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	2.89	2015-03-04	doi.org/10.1126/science.aaa5026
	4XT3	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	3.8	2015-03-04	doi.org/10.1126/science.aaa5026
	5WB1	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	-	-	-	3.51	2018-06-13	doi.org/10.7554/eLife.35850
	5WB2	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	CX3CL1.35	-	-	3.5	2018-06-13	doi.org/10.7554/eLife.35850

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7RKF_nogp.zip

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