psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C23	R:R:C263	7.28	No	No	0	8	6
2	R:R:F25	R:R:L29	7.31	No	No	0	3	3
3	R:R:F25	R:R:Q172	3.51	No	No	0	3	3
4	R:R:D27	R:R:V28	4.38	No	No	5	3	4
5	R:R:D27	R:R:R267	8.34	No	No	5	3	3
6	R:R:R267	R:R:V28	6.54	No	No	5	3	4
7	R:R:R271	R:R:V28	13.08	No	No	0	2	4
8	R:R:K270	R:R:L29	2.82	No	No	0	4	3
9	R:R:K33	R:R:N30	2.8	Yes	No	0	4	4
10	R:R:I274	R:R:S32	3.1	No	No	0	5	3
11	R:R:K33	R:R:P34	3.35	Yes	No	0	4	3
12	R:R:K33	R:R:L37	4.23	Yes	Yes	6	4	4
13	R:R:K33	R:R:L93	7.05	Yes	No	6	4	6
14	R:R:T36	R:R:Y40	8.74	No	Yes	2	5	7
15	R:R:S278	R:R:T36	3.2	No	No	2	5	5
16	R:R:L37	R:R:M90	2.83	Yes	No	0	4	7
17	R:R:L37	R:R:L93	6.92	Yes	No	6	4	6
18	R:R:F38	R:R:V42	6.55	No	No	0	5	5
19	R:R:M90	R:R:Y40	3.59	No	Yes	0	7	7
20	R:R:S278	R:R:Y40	6.36	No	Yes	2	5	7
21	R:R:F281	R:R:Y40	7.22	Yes	Yes	2	7	7
22	R:R:G41	R:R:M90	3.49	No	No	0	5	7
23	R:R:L86	R:R:V43	2.98	No	No	0	8	7
24	R:R:C282	R:R:V43	3.42	No	No	0	6	7
25	R:R:C285	R:R:V43	5.12	No	No	0	7	7
26	R:R:F44	R:R:V83	5.24	No	No	0	6	6
27	R:R:F44	R:R:L86	3.65	No	No	0	6	8
28	R:R:F44	R:R:P87	10.11	No	No	0	6	9
29	R:R:F46	R:R:L45	3.65	No	No	0	5	5
30	R:R:C285	R:R:G47	3.92	No	No	0	7	8
31	R:R:G50	R:R:I49	3.53	No	No	0	7	4
32	R:R:A76	R:R:N51	3.13	No	Yes	0	8	9
33	R:R:D79	R:R:N51	10.77	Yes	Yes	0	9	9
34	R:R:N51	R:R:P288	9.77	Yes	Yes	0	9	9
35	R:R:F52	R:R:F56	7.5	No	No	0	2	3
36	R:R:L302	R:R:L53	5.54	Yes	No	0	6	6
37	R:R:A76	R:R:V54	3.39	No	Yes	0	8	9
38	R:R:P288	R:R:V54	3.53	Yes	Yes	1	9	9
39	R:R:V292	R:R:V54	9.62	Yes	Yes	1	7	9
40	R:R:F293	R:R:V54	3.93	Yes	Yes	1	7	9
41	R:R:I55	R:R:I73	2.94	No	Yes	4	7	5
42	R:R:A76	R:R:I55	3.25	No	No	0	8	7
43	R:R:F56	R:R:W60	18.04	No	No	7	3	4
44	R:R:F56	R:R:L305	3.65	No	No	7	3	4
45	R:R:E301	R:R:T57	2.82	No	No	0	4	6
46	R:R:L302	R:R:T57	5.9	Yes	No	0	6	6
47	R:R:L305	R:R:T57	4.42	No	No	0	4	6
48	R:R:D69	R:R:I58	4.2	Yes	No	0	8	6
49	R:R:I58	R:R:I73	5.89	No	Yes	4	6	5
50	R:R:R61	R:R:W60	7	No	No	0	5	4
51	R:R:L305	R:R:W60	5.69	No	No	7	4	4
52	R:R:E308	R:R:R61	4.65	No	No	0	4	5
53	R:R:I64	R:R:I73	2.94	No	Yes	0	6	5
54	R:R:I64	R:R:V141	4.61	No	No	0	6	4
55	R:R:D69	R:R:Q65	3.92	Yes	No	0	8	6
56	R:R:C66	R:R:D69	3.11	No	Yes	0	7	8
57	R:R:D128	R:R:S67	8.83	No	No	0	8	6
58	R:R:D69	R:R:F298	5.97	Yes	Yes	0	8	8
59	R:R:N74	R:R:V70	2.96	Yes	Yes	1	9	6
60	R:R:A144	R:R:V70	5.09	No	Yes	0	8	6
61	R:R:C145	R:R:V70	3.42	No	Yes	0	4	6
62	R:R:S148	R:R:V70	3.23	No	Yes	1	7	6
63	R:R:E124	R:R:Y71	15.71	No	Yes	0	6	7
64	R:R:D128	R:R:Y71	9.2	No	Yes	8	8	7
65	R:R:R139	R:R:Y71	8.23	No	Yes	8	7	7
66	R:R:A144	R:R:Y71	4	No	Yes	0	8	7
67	R:R:F72	R:R:I125	5.02	Yes	No	1	8	8
68	R:R:F72	R:R:Y291	5.16	Yes	Yes	1	8	9
69	R:R:F72	R:R:V292	5.24	Yes	Yes	1	8	7
70	R:R:F298	R:R:F72	3.22	Yes	Yes	1	8	8
71	R:R:F121	R:R:N74	16.92	Yes	Yes	1	7	9
72	R:R:N74	R:R:S148	8.94	Yes	No	1	9	7
73	R:R:N74	R:R:W152	5.65	Yes	Yes	1	9	9
74	R:R:D79	R:R:L75	4.07	Yes	Yes	1	9	9
75	R:R:L75	R:R:S118	3	Yes	No	1	9	9
76	R:R:I122	R:R:L75	5.71	Yes	Yes	1	8	9
77	R:R:L75	R:R:N287	9.61	Yes	Yes	1	9	9
78	R:R:D79	R:R:S118	4.42	Yes	No	1	9	9
79	R:R:C284	R:R:D79	4.67	No	Yes	0	8	9
80	R:R:D79	R:R:N287	6.73	Yes	Yes	1	9	9
81	R:R:C110	R:R:L81	4.76	No	No	0	4	6
82	R:R:A114	R:R:L81	4.73	No	No	0	8	6
83	R:R:F111	R:R:F82	6.43	Yes	No	2	7	7
84	R:R:F281	R:R:F82	11.79	Yes	No	2	7	7
85	R:R:C284	R:R:F82	4.19	No	No	0	8	7
86	R:R:T85	R:R:W89	4.85	No	No	2	7	7
87	R:R:L107	R:R:T85	4.42	No	No	2	5	7
88	R:R:L107	R:R:L88	6.92	No	No	0	5	6
89	R:R:L107	R:R:W89	11.39	No	No	2	5	7
90	R:R:Q91	R:R:S98	8.66	No	No	0	4	3
91	R:R:H96	R:R:Y92	9.8	No	No	0	5	6
92	R:R:L99	R:R:Y92	8.21	No	No	0	7	6
93	R:R:C173	R:R:Y92	4.03	No	No	0	9	6
94	R:R:L99	R:R:P103	3.28	No	No	0	7	5
95	R:R:C104	R:R:L99	6.35	No	No	0	9	7
96	R:R:A100	R:R:P103	3.74	No	No	0	8	5
97	R:R:K169	R:R:S101	9.18	No	No	0	3	4
98	R:R:P103	R:R:V102	3.53	No	No	0	5	3
99	R:R:C104	R:R:C173	7.28	No	No	0	9	9
100	R:R:T105	R:R:T167	9.42	No	No	0	8	4
101	R:R:T108	R:R:V166	7.93	No	No	0	6	5
102	R:R:A109	R:R:F163	5.55	No	Yes	0	5	4
103	R:R:F111	R:R:Y112	9.28	Yes	No	2	7	5
104	R:R:F111	R:R:F281	4.29	Yes	Yes	2	7	7
105	R:R:F116	R:R:Y112	3.09	Yes	No	2	7	5
106	R:R:H162	R:R:Y112	16.33	Yes	No	2	4	5
107	R:R:V113	R:R:V156	3.21	No	No	0	5	3
108	R:R:F116	R:R:M115	4.98	Yes	No	0	7	8
109	R:R:M115	R:R:W241	3.49	No	Yes	0	8	8
110	R:R:F116	R:R:I158	10.05	Yes	No	0	7	5
111	R:R:F116	R:R:H162	7.92	Yes	Yes	2	7	4
112	R:R:A117	R:R:W152	7.78	No	Yes	0	7	9
113	R:R:C120	R:R:W151	7.84	No	No	0	5	6
114	R:R:F121	R:R:S148	5.28	Yes	No	1	7	7
115	R:R:F121	R:R:W151	5.01	Yes	No	0	7	6
116	R:R:F121	R:R:W152	9.02	Yes	Yes	1	7	9
117	R:R:H283	R:R:I122	3.98	Yes	Yes	1	9	8
118	R:R:I122	R:R:N287	5.66	Yes	Yes	1	8	9
119	R:R:I122	R:R:Y291	7.25	Yes	Yes	1	8	9
120	R:R:L127	R:R:T123	2.95	No	No	9	6	7
121	R:R:P200	R:R:T123	3.5	No	No	0	9	7
122	R:R:T123	R:R:V203	3.17	No	No	9	7	6
123	R:R:E124	R:R:W151	14.17	No	No	0	6	6
124	R:R:I125	R:R:R129	6.26	No	No	0	8	9
125	R:R:I125	R:R:Y291	7.25	No	Yes	1	8	9
126	R:R:A126	R:R:I204	3.25	No	No	0	9	7
127	R:R:A126	R:R:C207	3.61	No	No	0	9	6
128	R:R:A126	R:R:Y208	6.67	No	Yes	0	9	8
129	R:R:L127	R:R:V203	2.98	No	No	9	6	6
130	R:R:D128	R:R:R139	7.15	No	No	8	8	7
131	R:R:R129	R:R:Y208	6.17	No	Yes	0	9	8
132	R:R:V134	R:R:Y130	8.83	Yes	Yes	3	7	8
133	R:R:Y130	R:R:Y135	5.96	Yes	No	3	8	6
134	R:R:Y130	R:R:Y206	4.96	Yes	No	3	8	3
135	R:R:C207	R:R:Y130	9.41	No	Yes	0	6	8
136	R:R:R210	R:R:Y130	7.2	No	Yes	3	3	8
137	R:R:A132	R:R:Y138	4	No	No	0	7	4
138	R:R:I133	R:R:V134	3.07	No	Yes	0	8	7
139	R:R:I133	R:R:I211	11.77	No	No	0	8	8
140	R:R:V134	R:R:Y135	8.83	Yes	No	3	7	6
141	R:R:I214	R:R:V134	3.07	No	Yes	0	5	7
142	R:R:F147	R:R:R139	14.97	No	No	0	5	7
143	R:R:P140	R:R:Q143	6.32	No	No	0	6	3
144	R:R:F147	R:R:Q143	3.51	No	No	0	5	3
145	R:R:F150	R:R:L146	8.53	No	No	0	2	2
146	R:R:F154	R:R:I157	3.77	No	No	0	4	3
147	R:R:E191	R:R:I158	5.47	No	No	0	2	5
148	R:R:I160	R:R:P161	3.39	No	No	0	5	9
149	R:R:L188	R:R:P161	3.28	No	No	0	5	9
150	R:R:H162	R:R:L188	12.86	Yes	No	0	4	5
151	R:R:E191	R:R:H162	11.08	No	Yes	0	2	4
152	R:R:H162	R:R:L192	6.43	Yes	No	0	4	5
153	R:R:F163	R:R:M164	8.71	Yes	No	0	4	4
154	R:R:V165	R:R:Y177	6.31	No	Yes	10	5	5
155	R:R:L180	R:R:V165	2.98	Yes	No	10	3	5
156	R:R:D176	R:R:K168	11.06	Yes	No	0	4	4
157	R:R:D170	R:R:N171	4.04	No	No	0	1	5
158	R:R:D170	R:R:D176	6.65	No	Yes	0	1	4
159	R:R:M174	R:R:Q172	12.23	No	No	0	4	3
160	R:R:M174	R:R:T175	4.52	No	No	0	4	5
161	R:R:D176	R:R:M174	5.54	Yes	No	0	4	4
162	R:R:T175	R:R:Y177	17.48	No	Yes	0	5	5
163	R:R:L180	R:R:Y177	3.52	Yes	Yes	10	3	5
164	R:R:P185	R:R:Y177	20.86	No	Yes	0	3	5
165	R:R:L188	R:R:Y177	3.52	No	Yes	0	5	5
166	R:R:L180	R:R:Y179	4.69	Yes	No	0	3	1
167	R:R:L180	R:R:Y184	5.86	Yes	No	0	3	4
168	R:R:L255	R:R:P185	3.28	Yes	No	0	4	3
169	R:R:I186	R:R:T252	3.04	Yes	No	0	3	6
170	R:R:I186	R:R:L255	5.71	Yes	Yes	0	3	4
171	R:R:L248	R:R:N189	15.1	No	No	11	5	5
172	R:R:N189	R:R:T252	4.39	No	No	11	5	6
173	R:R:L248	R:R:M193	5.65	No	No	0	5	5
174	R:R:F249	R:R:M193	7.46	No	No	0	5	5
175	R:R:L194	R:R:V198	2.98	No	No	0	4	5
176	R:R:I199	R:R:L194	2.85	No	No	0	5	4
177	R:R:A196	R:R:H245	2.93	No	No	0	6	8
178	R:R:F197	R:R:L242	7.31	No	No	0	9	5
179	R:R:F197	R:R:H245	19.23	No	No	0	9	8
180	R:R:I199	R:R:P200	3.39	No	No	0	5	9
181	R:R:I204	R:R:L201	2.85	No	Yes	1	7	6
182	R:R:L201	R:R:S205	4.5	Yes	No	0	6	5
183	R:R:F237	R:R:L201	7.31	Yes	Yes	1	9	6
184	R:R:I238	R:R:L201	4.28	No	Yes	0	5	6
185	R:R:F237	R:R:I204	5.02	Yes	No	1	9	7
186	R:R:R210	R:R:Y206	13.38	No	No	3	3	3
187	R:R:L230	R:R:Y208	17.58	No	Yes	0	7	8
188	R:R:V233	R:R:Y208	3.79	No	Yes	0	7	8
189	R:R:R213	R:R:Y209	10.29	No	No	0	4	3
190	R:R:I211	R:R:L230	2.85	No	No	0	8	7
191	R:R:S212	R:R:V227	4.85	No	No	0	4	5
192	R:R:S218	R:R:V215	3.23	No	No	0	5	8
193	R:R:I226	R:R:V215	9.22	No	No	0	7	8
194	R:R:H222	R:R:R221	6.77	No	No	0	5	4
195	R:R:R225	R:R:R228	5.33	No	No	0	7	6
196	R:R:R225	R:R:R299	3.2	No	No	0	7	8
197	R:R:I231	R:R:V227	3.07	No	No	0	4	5
198	R:R:V229	R:R:V294	4.81	No	No	0	7	6
199	R:R:I231	R:R:L235	2.85	No	No	0	4	5
200	R:R:L290	R:R:V233	2.98	Yes	No	1	7	7
201	R:R:V233	R:R:Y291	5.05	No	Yes	1	7	9
202	R:R:I238	R:R:V234	3.07	No	No	0	5	8
203	R:R:F240	R:R:V236	3.93	Yes	No	0	7	6
204	R:R:L286	R:R:V236	2.98	No	No	1	7	6
205	R:R:L290	R:R:V236	7.45	Yes	No	1	7	6
206	R:R:F237	R:R:W241	8.02	Yes	Yes	1	9	8
207	R:R:F237	R:R:H283	3.39	Yes	Yes	1	9	9
208	R:R:I238	R:R:L242	2.85	No	No	0	5	5
209	R:R:F240	R:R:I239	6.28	Yes	No	0	7	5
210	R:R:F240	R:R:L279	4.87	Yes	No	0	7	7
211	R:R:H245	R:R:W241	4.23	No	Yes	0	8	8
212	R:R:H283	R:R:W241	13.75	Yes	Yes	1	9	8
213	R:R:L242	R:R:P243	3.28	No	No	0	5	9
214	R:R:P243	R:R:T276	3.5	No	No	0	9	6
215	R:R:L279	R:R:P243	3.28	No	No	0	7	9
216	R:R:E277	R:R:Y244	7.86	No	No	0	6	6
217	R:R:L273	R:R:T247	4.42	No	No	0	5	5
218	R:R:T247	R:R:T276	6.28	No	No	0	5	6
219	R:R:L248	R:R:T252	2.95	No	No	11	5	6
220	R:R:F249	R:R:L253	7.31	No	No	0	5	4
221	R:R:D251	R:R:L269	8.14	No	No	0	5	5
222	R:R:I259	R:R:L253	4.28	No	No	0	1	4
223	R:R:K254	R:R:L255	2.82	No	Yes	0	3	4
224	R:R:K254	R:R:K257	5.75	No	No	0	3	3
225	R:R:K254	R:R:S261	9.18	No	No	0	3	3
226	R:R:L256	R:R:W258	18.22	No	No	0	2	2
227	R:R:E266	R:R:S261	7.19	No	No	0	3	3
228	R:R:E277	R:R:F281	7	No	Yes	0	6	7
229	R:R:H283	R:R:N287	8.93	Yes	Yes	1	9	9
230	R:R:L286	R:R:L290	4.15	No	Yes	1	7	7
231	R:R:N287	R:R:Y291	3.49	Yes	Yes	1	9	9
232	R:R:F293	R:R:P288	2.89	Yes	Yes	1	7	9
233	R:R:L290	R:R:Y291	3.52	Yes	Yes	1	7	9
234	R:R:F293	R:R:V292	5.24	Yes	Yes	1	7	7
235	R:R:F298	R:R:V292	5.24	Yes	Yes	1	8	7
236	R:R:F293	R:R:L302	7.31	Yes	Yes	0	7	6
237	R:R:Q300	R:R:R314	4.67	No	No	0	5	1
238	R:R:L302	R:R:L306	8.3	Yes	No	0	6	6
239	R:R:H303	R:R:L311	6.43	No	Yes	0	4	3
240	R:R:H303	R:R:R314	12.41	No	No	0	4	1
241	R:R:L306	R:R:L311	4.15	No	Yes	13	6	3
242	R:R:P313	R:R:V312	5.3	No	No	0	5	3
243	R:R:C23	R:R:R267	2.79	No	No	0	8	3
244	R:R:C120	R:R:F154	2.79	No	No	0	5	4
245	R:R:C282	R:R:F240	2.79	No	Yes	0	6	7
246	R:R:A159	R:R:F116	2.77	No	Yes	0	7	7
247	R:R:L269	R:R:L273	2.77	No	No	0	5	5
248	R:R:L80	R:R:N51	2.75	No	Yes	0	7	9
249	R:R:D176	R:R:D178	2.66	Yes	No	0	4	6
250	R:R:R271	R:R:S32	2.64	No	No	0	2	3
251	R:R:F265	R:R:S261	2.64	No	No	0	1	3
252	R:R:F265	R:R:S262	2.64	No	No	0	1	6
253	R:R:F46	R:R:V42	2.62	No	No	0	5	5
254	R:R:A78	R:R:W152	2.59	No	Yes	0	8	9
255	R:R:F163	R:R:T108	2.59	Yes	No	0	4	6
256	R:R:R225	R:R:T296	2.59	No	No	0	7	5
257	R:R:F163	R:R:I160	2.51	Yes	No	0	4	5
258	R:R:V113	R:R:W152	2.45	No	Yes	0	5	9
259	R:R:F121	R:R:L75	2.44	Yes	Yes	1	7	9
260	R:R:F237	R:R:L119	2.44	Yes	No	0	9	7
261	R:R:Q65	R:R:R62	2.34	No	No	0	6	5
262	R:R:L127	R:R:Y131	2.34	No	No	0	6	5
263	R:R:F147	R:R:F150	2.14	No	No	0	5	2
264	R:R:G50	R:R:P288	2.03	No	Yes	0	7	9
265	R:R:F111	R:R:W89	2	Yes	No	2	7	7
266	R:R:Y131	R:R:Y135	1.99	No	No	0	5	6
267	R:R:C66	R:R:G68	1.96	No	No	0	7	7
268	R:R:G295	R:R:V294	1.84	No	No	0	8	6
269	R:R:A155	R:R:C120	1.81	No	No	0	7	5
270	R:R:G224	R:R:K223	1.74	No	No	0	6	7
271	R:R:C173	R:R:V166	1.71	No	No	0	9	5
272	R:R:G195	R:R:L194	1.71	No	No	0	3	4
273	R:R:C110	R:R:T85	1.69	No	No	0	4	7
274	R:R:A272	R:R:T247	1.68	No	No	0	4	5
275	R:R:S218	R:R:S220	1.63	No	No	12	5	4
276	R:R:S48	R:R:V83	1.62	No	No	0	5	6
277	R:R:S101	R:R:V102	1.62	No	No	0	4	3
278	R:R:S202	R:R:V198	1.62	No	No	0	3	5
279	R:R:I186	R:R:V190	1.54	Yes	No	0	3	4
280	R:R:I211	R:R:V215	1.54	No	No	0	8	8
281	R:R:K223	R:R:S218	1.53	No	No	12	7	5
282	R:R:K223	R:R:S220	1.53	No	No	12	7	4
283	R:R:I274	R:R:T36	1.52	No	No	0	5	5
284	R:R:I55	R:R:T59	1.52	No	No	4	7	2
285	R:R:I58	R:R:T59	1.52	No	No	4	6	2
286	R:R:I73	R:R:T59	1.52	Yes	No	4	5	2
287	R:R:F298	R:R:G295	1.51	Yes	No	0	8	8
288	R:R:G224	R:R:R228	1.5	No	No	0	6	6
289	R:R:K297	R:R:T296	1.5	No	No	0	7	5
290	R:R:L255	R:R:V182	1.49	Yes	No	0	4	1
291	R:R:L269	R:R:V250	1.49	No	No	0	5	5
292	R:R:L311	R:R:V312	1.49	Yes	No	0	3	3
293	R:R:D95	R:R:S98	1.47	No	No	0	4	3
294	R:R:I149	R:R:I153	1.47	No	No	0	4	3
295	R:R:I153	R:R:I157	1.47	No	No	0	3	3
296	R:R:N30	R:R:T26	1.46	No	No	0	4	4
297	R:R:E264	R:R:S262	1.44	No	No	0	4	6
298	R:R:I186	R:R:L256	1.43	Yes	No	0	3	2
299	R:R:H222	R:R:S220	1.39	No	No	0	5	4
300	R:R:L37	R:R:L94	1.38	Yes	No	0	4	5
301	R:R:L286	R:R:L289	1.38	No	No	0	7	6
302	R:R:A77	R:R:W152	1.3	No	Yes	0	5	9
303	R:R:F163	R:R:T105	1.3	Yes	No	0	4	8
304	R:R:A280	R:R:W241	1.3	No	Yes	0	8	8
305	R:R:H96	R:R:N97	1.28	No	No	0	5	9
306	R:R:S212	R:R:Y209	1.27	No	No	0	4	3
307	R:R:F38	R:R:L39	1.22	No	No	0	5	5
308	R:R:L306	R:R:R310	1.21	No	No	13	6	3
309	R:R:L311	R:R:R310	1.21	Yes	No	13	3	3
310	R:R:M136	R:R:Y138	1.2	No	No	0	4	4
311	R:R:Q31	R:R:R271	1.17	No	No	0	4	2
312	R:R:E308	R:R:F309	1.17	No	No	0	4	4
313	R:R:R137	R:R:Y131	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K33	4.3575	4	6	4
2	R:R:L37	3.84	4	6	4
3	R:R:Y40	6.4775	4	2	7
4	R:R:N51	6.605	4	0	9
5	R:R:V54	5.1175	4	1	9
6	R:R:D69	4.3	4	0	8
7	R:R:V70	3.675	4	1	6
8	R:R:Y71	9.285	4	8	7
9	R:R:F72	4.66	4	1	8
10	R:R:I73	3.3225	4	4	5
11	R:R:N74	8.6175	4	1	9
12	R:R:L75	4.966	5	1	9
13	R:R:D79	6.132	5	1	9
14	R:R:F111	5.5	4	2	7
15	R:R:F116	5.762	5	2	7
16	R:R:F121	7.734	5	1	7
17	R:R:I122	5.65	4	1	8
18	R:R:Y130	7.272	5	3	8
19	R:R:V134	5.95	4	3	7
20	R:R:W152	4.79833	6	1	9
21	R:R:H162	10.924	5	2	4
22	R:R:F163	4.132	5	0	4
23	R:R:D176	6.4775	4	0	4
24	R:R:Y177	10.338	5	10	5
25	R:R:L180	4.2625	4	10	3
26	R:R:I186	2.93	4	0	3
27	R:R:L201	4.735	4	1	6
28	R:R:Y208	8.5525	4	0	8
29	R:R:F237	5.236	5	1	9
30	R:R:F240	4.4675	4	0	7
31	R:R:W241	6.158	5	1	8
32	R:R:L255	3.325	4	0	4
33	R:R:F281	7.575	4	2	7
34	R:R:H283	7.5125	4	1	9
35	R:R:N287	6.884	5	1	9
36	R:R:P288	4.555	4	1	9
37	R:R:L290	4.525	4	1	7
38	R:R:Y291	5.28667	6	1	9
39	R:R:V292	6.335	4	1	7
40	R:R:F293	4.8425	4	1	7
41	R:R:F298	3.985	4	1	8
42	R:R:L302	6.7625	4	0	6
43	R:R:L311	3.32	4	13	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R271	R:R:S32	10.8099	2.64	No	No	0	2	3
2	R:R:I274	R:R:S32	12.3222	3.1	No	No	0	5	3
3	R:R:I274	R:R:T36	13.725	1.52	No	No	0	5	5
4	R:R:T36	R:R:Y40	15.1726	8.74	No	Yes	2	5	7
5	R:R:F281	R:R:Y40	30.9273	7.22	Yes	Yes	2	7	7
6	R:R:F111	R:R:F281	14.2871	4.29	Yes	Yes	2	7	7
7	R:R:F111	R:R:Y112	42.9161	9.28	Yes	No	2	7	5
8	R:R:H162	R:R:Y112	34.8672	16.33	Yes	No	2	4	5
9	R:R:H162	R:R:L188	100	12.86	Yes	No	0	4	5
10	R:R:L188	R:R:Y177	62.6555	3.52	No	Yes	0	5	5
11	R:R:T175	R:R:Y177	20.0229	17.48	No	Yes	0	5	5
12	R:R:M174	R:R:T175	18.242	4.52	No	No	0	4	5
13	R:R:M90	R:R:Y40	13.8295	3.59	No	Yes	0	7	7
14	R:R:L37	R:R:M90	10.8248	2.83	Yes	No	0	4	7
15	R:R:F281	R:R:F82	20.7094	11.79	Yes	No	2	7	7
16	R:R:C284	R:R:F82	51.2238	4.19	No	No	0	8	7
17	R:R:C284	R:R:D79	51.7162	4.67	No	Yes	0	8	9
18	R:R:D79	R:R:N287	23.2116	6.73	Yes	Yes	1	9	9
19	R:R:N287	R:R:Y291	42.4087	3.49	Yes	Yes	1	9	9
20	R:R:L290	R:R:Y291	30.0318	3.52	Yes	Yes	1	7	9
21	R:R:L290	R:R:V236	28.6787	7.45	Yes	No	1	7	6
22	R:R:F240	R:R:V236	27.2162	3.93	Yes	No	0	7	6
23	R:R:C282	R:R:F240	20.59	2.79	No	Yes	0	6	7
24	R:R:C282	R:R:V43	18.3415	3.42	No	No	0	6	7
25	R:R:L86	R:R:V43	11.5362	2.98	No	No	0	8	7
26	R:R:D79	R:R:N51	31.6735	10.77	Yes	Yes	0	9	9
27	R:R:N51	R:R:P288	21.4606	9.77	Yes	Yes	0	9	9
28	R:R:F293	R:R:P288	18.3464	2.89	Yes	Yes	1	7	9
29	R:R:F293	R:R:L302	31.1959	7.31	Yes	Yes	0	7	6
30	R:R:L302	R:R:T57	15.2074	5.9	Yes	No	0	6	6
31	R:R:L305	R:R:T57	11.954	4.42	No	No	0	4	6
32	R:R:F293	R:R:V292	17.7594	5.24	Yes	Yes	1	7	7
33	R:R:F72	R:R:Y291	35.29	5.16	Yes	Yes	1	8	9
34	R:R:F72	R:R:V292	21.5401	5.24	Yes	Yes	1	8	7
35	R:R:F298	R:R:F72	21.1074	3.22	Yes	Yes	1	8	8
36	R:R:D69	R:R:F298	14.8244	5.97	Yes	Yes	0	8	8
37	R:R:D79	R:R:L75	22.8335	4.07	Yes	Yes	1	9	9
38	R:R:F121	R:R:L75	86.0959	2.44	Yes	Yes	1	7	9
39	R:R:F121	R:R:W151	46.463	5.01	Yes	No	0	7	6
40	R:R:E124	R:R:W151	27.5196	14.17	No	No	0	6	6
41	R:R:E124	R:R:Y71	24.8035	15.71	No	Yes	0	6	7
42	R:R:F121	R:R:N74	10.9094	16.92	Yes	Yes	1	7	9
43	R:R:F121	R:R:S148	10.9392	5.28	Yes	No	1	7	7
44	R:R:R139	R:R:Y71	16.7993	8.23	No	Yes	8	7	7
45	R:R:F121	R:R:W152	16.7396	9.02	Yes	Yes	1	7	9
46	R:R:I122	R:R:L75	33.8126	5.71	Yes	Yes	1	8	9
47	R:R:L188	R:R:P161	45.6522	3.28	No	No	0	5	9
48	R:R:I160	R:R:P161	44.0205	3.39	No	No	0	5	9
49	R:R:F163	R:R:I160	42.3789	2.51	Yes	No	0	4	5
50	R:R:F163	R:R:T108	34.0215	2.59	Yes	No	0	4	6
51	R:R:T108	R:R:V166	32.3202	7.93	No	No	0	6	5
52	R:R:C173	R:R:V166	30.6089	1.71	No	No	0	9	5
53	R:R:C173	R:R:Y92	16.2621	4.03	No	No	0	9	6
54	R:R:L99	R:R:Y92	10.9342	8.21	No	No	0	7	6
55	R:R:C104	R:R:C173	12.6505	7.28	No	No	0	9	9
56	R:R:C104	R:R:L99	10.8745	6.35	No	No	0	9	7
57	R:R:L99	R:R:P103	18.1773	3.28	No	No	0	7	5
58	R:R:P103	R:R:V102	10.9342	3.53	No	No	0	5	3
59	R:R:F116	R:R:M115	79.7582	4.98	Yes	No	0	7	8
60	R:R:M115	R:R:W241	80.6338	3.49	No	Yes	0	8	8
61	R:R:C120	R:R:W151	16.9187	7.84	No	No	0	5	6
62	R:R:H283	R:R:N287	44.2294	8.93	Yes	Yes	1	9	9
63	R:R:F237	R:R:H283	21.6496	3.39	Yes	Yes	1	9	9
64	R:R:F237	R:R:I204	29.5891	5.02	Yes	No	1	9	7
65	R:R:A126	R:R:I204	31.564	3.25	No	No	0	9	7
66	R:R:A126	R:R:C207	40.8865	3.61	No	No	0	9	6
67	R:R:C207	R:R:Y130	38.7275	9.41	No	Yes	0	6	8
68	R:R:Y130	R:R:Y135	27.1565	5.96	Yes	No	3	8	6
69	R:R:Y131	R:R:Y135	25.9327	1.99	No	No	0	5	6
70	R:R:L127	R:R:Y131	21.3063	2.34	No	No	0	6	5
71	R:R:F237	R:R:W241	21.3959	8.02	Yes	Yes	1	9	8
72	R:R:V233	R:R:Y291	30.9671	5.05	No	Yes	1	7	9
73	R:R:V233	R:R:Y208	33.6136	3.79	No	Yes	0	7	8
74	R:R:A126	R:R:Y208	29.6189	6.67	No	Yes	0	9	8
75	R:R:L127	R:R:T123	16.6053	2.95	No	No	9	6	7
76	R:R:P200	R:R:T123	14.2921	3.5	No	No	0	9	7
77	R:R:I125	R:R:R129	10.5213	6.26	No	No	0	8	9
78	R:R:L230	R:R:Y208	28.4002	17.58	No	Yes	0	7	8
79	R:R:I211	R:R:L230	26.8879	2.85	No	No	0	8	7
80	R:R:F147	R:R:R139	14.2225	14.97	No	No	0	5	7
81	R:R:C120	R:R:F154	11.3173	2.79	No	No	0	5	4
82	R:R:P185	R:R:Y177	37.2898	20.86	No	Yes	0	3	5
83	R:R:L255	R:R:P185	35.5984	3.28	Yes	No	0	4	3
84	R:R:I186	R:R:L255	20.1174	5.71	Yes	Yes	0	3	4
85	R:R:I186	R:R:T252	12.949	3.04	Yes	No	0	3	6
86	R:R:I199	R:R:P200	11.9341	3.39	No	No	0	5	9
87	R:R:H245	R:R:W241	18.5504	4.23	No	Yes	0	8	8
88	R:R:F197	R:R:H245	15.4064	19.23	No	No	0	9	8
89	R:R:F197	R:R:L242	14.0782	7.31	No	No	0	9	5
90	R:R:F237	R:R:L201	10.6656	7.31	Yes	Yes	1	9	6
91	R:R:I238	R:R:L201	10.2428	4.28	No	Yes	0	5	6
92	R:R:I211	R:R:V215	22.6346	1.54	No	No	0	8	8
93	R:R:S218	R:R:V215	19.2319	3.23	No	No	0	5	8
94	R:R:K223	R:R:S218	12.2028	1.53	No	No	12	7	5
95	R:R:G224	R:R:K223	10.5512	1.74	No	No	0	6	7
96	R:R:F240	R:R:L279	12.551	4.87	Yes	No	0	7	7
97	R:R:L242	R:R:P243	18.3265	3.28	No	No	0	5	9
98	R:R:P243	R:R:T276	16.9187	3.5	No	No	0	9	6
99	R:R:T247	R:R:T276	14.5309	6.28	No	No	0	5	6
100	R:R:K254	R:R:L255	12.949	2.82	No	Yes	0	3	4
101	R:R:L302	R:R:L306	13.6454	8.3	Yes	No	0	6	6
102	R:R:L306	R:R:L311	10.2627	4.15	No	Yes	13	6	3
103	R:R:F116	R:R:H162	68.237	7.92	Yes	Yes	2	7	4
104	R:R:L279	R:R:P243	12.0784	3.28	No	No	0	7	9
105	R:R:H283	R:R:W241	57.6012	13.75	Yes	Yes	1	9	8
106	R:R:H283	R:R:I122	35.6631	3.98	Yes	Yes	1	9	8
107	R:R:I122	R:R:Y291	28.4599	7.25	Yes	Yes	1	8	9
108	R:R:F111	R:R:F82	30.0816	6.43	Yes	No	2	7	7
109	R:R:L75	R:R:N287	33.5787	9.61	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5WB1

PDB Summary
PDB	5WB1
Class	A
SubFamily	Other
Type	Unclassified
SubType	US28
Species	Human Cytomegalovirus (Strain Towne)
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.51
Date	2018-06-13
D.O.I.	10.7554/eLife.35850

Net Summary
I_min	2.8
Number of Linked Nodes	273
Number of Links	313
Number of Hubs	43
Number of Links mediated by Hubs	148
Number of Communities	13
Number of Nodes involved in Communities	75
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	110
Number Of Links MetaPath	109
Number of Shortest Paths	54637
Length Of Smallest Path	3
Average Path Length	13.9627
Length of Longest Path	31
Minimum Path Strength	1.35
Average Path Strength	6.01867
Maximum Path Strength	19.17
Minimum Path Correlation	0.7
Average Path Correlation	0.932414
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.7355
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9217
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cellular process • cell motility • locomotion • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • immune response • immune system process • cellular anatomical structure • membrane • host cell plasma membrane • host cellular component • host cell part • host cell membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P69333
Sequence	>5WB1_Chain_R P C V F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R R R I Q C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D H N S L A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y M R Y R P V K Q A C L F S I F W W I F A V I I A I P H F M V V T K K D N Q C M T D Y D Y L E V S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S Q S R H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K W I S S S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K F R Q E L H C L L A E F R L V P R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKF	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP	chim(NtGi1-G11)/β1/γ2	4	2022-01-26	10.1126/sciadv.abl5442
	7RKF (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP		4	2022-01-26	10.1126/sciadv.abl5442
	7RKN	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.6	2022-01-26	10.1126/sciadv.abl5442
	7RKN (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.6	2022-01-26	10.1126/sciadv.abl5442
	7RKM	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.5	2022-01-26	10.1126/sciadv.abl5442
	7RKM (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.5	2022-01-26	10.1126/sciadv.abl5442
	5WB2	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	CX3CL1.35	-	-	3.5	2018-06-13	10.7554/eLife.35850
	5WB1	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	-	-	-	3.51	2018-06-13	10.7554/eLife.35850
	4XT3	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	3.8	2015-03-04	10.1126/science.aaa5026
	4XT1	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	2.89	2015-03-04	10.1126/science.aaa5026

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5WB1.zip

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