psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C23	R:R:C263	7.28	No	No	0	8	6
2	R:R:C23	R:R:R267	2.79	No	No	0	8	3
3	R:R:F25	R:R:L29	7.31	No	No	0	3	3
4	R:R:F25	R:R:Q172	3.51	No	No	0	3	3
5	R:R:D27	R:R:V28	4.38	No	No	4	3	4
6	R:R:D27	R:R:R267	8.34	No	No	4	3	3
7	R:R:R267	R:R:V28	6.54	No	No	4	3	4
8	R:R:R271	R:R:V28	13.08	No	No	0	2	4
9	R:R:K270	R:R:L29	2.82	No	No	0	4	3
10	R:R:K33	R:R:N30	2.8	Yes	No	0	4	4
11	R:R:I274	R:R:S32	3.1	No	No	0	5	3
12	R:R:K33	R:R:P34	3.35	Yes	No	0	4	3
13	R:R:K33	R:R:L37	4.23	Yes	Yes	5	4	4
14	R:R:K33	R:R:L93	7.05	Yes	No	5	4	6
15	R:R:T36	R:R:Y40	8.74	No	Yes	2	5	7
16	R:R:S278	R:R:T36	3.2	No	No	2	5	5
17	R:R:L37	R:R:M90	2.83	Yes	No	0	4	7
18	R:R:L37	R:R:L93	6.92	Yes	No	5	4	6
19	R:R:F38	R:R:V42	6.55	No	No	0	5	5
20	R:R:M90	R:R:Y40	3.59	No	Yes	0	7	7
21	R:R:S278	R:R:Y40	6.36	No	Yes	2	5	7
22	R:R:F281	R:R:Y40	7.22	Yes	Yes	2	7	7
23	R:R:G41	R:R:M90	3.49	No	No	0	5	7
24	R:R:L86	R:R:V43	2.98	No	No	0	8	7
25	R:R:C282	R:R:V43	3.42	No	No	0	6	7
26	R:R:C285	R:R:V43	5.12	No	No	0	7	7
27	R:R:F44	R:R:V83	5.24	No	No	0	6	6
28	R:R:F44	R:R:L86	3.65	No	No	0	6	8
29	R:R:F44	R:R:P87	10.11	No	No	0	6	9
30	R:R:F46	R:R:L45	3.65	No	No	0	5	5
31	R:R:C285	R:R:G47	3.92	No	No	0	7	8
32	R:R:G50	R:R:I49	3.53	No	No	0	7	4
33	R:R:A76	R:R:N51	3.13	No	Yes	0	8	9
34	R:R:D79	R:R:N51	10.77	Yes	Yes	0	9	9
35	R:R:N51	R:R:P288	9.77	Yes	Yes	0	9	9
36	R:R:F52	R:R:F56	7.5	No	No	0	2	3
37	R:R:L302	R:R:L53	5.54	Yes	No	0	6	6
38	R:R:A76	R:R:V54	3.39	No	Yes	0	8	9
39	R:R:P288	R:R:V54	3.53	Yes	Yes	1	9	9
40	R:R:V292	R:R:V54	9.62	Yes	Yes	1	7	9
41	R:R:F293	R:R:V54	3.93	Yes	Yes	1	7	9
42	R:R:I55	R:R:I73	2.94	No	Yes	1	7	5
43	R:R:A76	R:R:I55	3.25	No	No	0	8	7
44	R:R:F56	R:R:W60	18.04	No	No	6	3	4
45	R:R:F56	R:R:L305	3.65	No	No	6	3	4
46	R:R:E301	R:R:T57	2.82	No	No	0	4	6
47	R:R:L302	R:R:T57	5.9	Yes	No	0	6	6
48	R:R:L305	R:R:T57	4.42	No	No	0	4	6
49	R:R:I58	R:R:R62	7.52	Yes	Yes	1	6	5
50	R:R:D69	R:R:I58	4.2	Yes	Yes	1	8	6
51	R:R:I58	R:R:I73	5.89	Yes	Yes	1	6	5
52	R:R:R61	R:R:W60	3	No	No	0	5	4
53	R:R:L305	R:R:W60	5.69	No	No	6	4	4
54	R:R:Q65	R:R:R62	3.5	No	Yes	0	6	5
55	R:R:D69	R:R:R62	3.57	Yes	Yes	1	8	5
56	R:R:E301	R:R:R62	9.3	No	Yes	0	4	5
57	R:R:I64	R:R:I73	2.94	No	Yes	0	6	5
58	R:R:I64	R:R:V141	4.61	No	No	0	6	4
59	R:R:C66	R:R:D69	3.11	No	Yes	0	7	8
60	R:R:D128	R:R:S67	8.83	No	No	0	8	6
61	R:R:D69	R:R:F298	5.97	Yes	Yes	1	8	8
62	R:R:N74	R:R:V70	2.96	Yes	Yes	1	9	6
63	R:R:A144	R:R:V70	5.09	No	Yes	0	8	6
64	R:R:C145	R:R:V70	3.42	No	Yes	0	4	6
65	R:R:S148	R:R:V70	3.23	No	Yes	1	7	6
66	R:R:E124	R:R:Y71	15.71	No	No	0	6	7
67	R:R:D128	R:R:Y71	9.2	No	No	0	8	7
68	R:R:A144	R:R:Y71	4	No	No	0	8	7
69	R:R:F72	R:R:I125	5.02	Yes	No	1	8	8
70	R:R:F72	R:R:Y291	5.16	Yes	Yes	1	8	9
71	R:R:F72	R:R:V292	5.24	Yes	Yes	1	8	7
72	R:R:F298	R:R:F72	3.22	Yes	Yes	1	8	8
73	R:R:F121	R:R:N74	16.92	Yes	Yes	1	7	9
74	R:R:N74	R:R:S148	8.94	Yes	No	1	9	7
75	R:R:N74	R:R:W152	5.65	Yes	Yes	1	9	9
76	R:R:D79	R:R:L75	4.07	Yes	Yes	1	9	9
77	R:R:L75	R:R:S118	3	Yes	No	1	9	9
78	R:R:I122	R:R:L75	5.71	Yes	Yes	1	8	9
79	R:R:L75	R:R:N287	9.61	Yes	Yes	1	9	9
80	R:R:D79	R:R:S118	4.42	Yes	No	1	9	9
81	R:R:C284	R:R:D79	4.67	No	Yes	0	8	9
82	R:R:D79	R:R:N287	6.73	Yes	Yes	1	9	9
83	R:R:C110	R:R:L81	4.76	No	No	0	4	6
84	R:R:A114	R:R:L81	4.73	No	No	0	8	6
85	R:R:F111	R:R:F82	6.43	Yes	No	2	7	7
86	R:R:F281	R:R:F82	11.79	Yes	No	2	7	7
87	R:R:C284	R:R:F82	4.19	No	No	0	8	7
88	R:R:T85	R:R:W89	4.85	No	No	2	7	7
89	R:R:L107	R:R:T85	4.42	No	No	2	5	7
90	R:R:L107	R:R:L88	6.92	No	No	0	5	6
91	R:R:L107	R:R:W89	11.39	No	No	2	5	7
92	R:R:Q91	R:R:S98	10.11	No	No	0	4	3
93	R:R:H96	R:R:Y92	9.8	No	No	0	5	6
94	R:R:L99	R:R:Y92	8.21	No	No	0	7	6
95	R:R:C173	R:R:Y92	4.03	No	No	0	9	6
96	R:R:D95	R:R:N97	5.39	No	No	0	4	9
97	R:R:L99	R:R:P103	3.28	No	No	0	7	5
98	R:R:C104	R:R:L99	6.35	No	No	0	9	7
99	R:R:A100	R:R:P103	3.74	No	No	0	8	5
100	R:R:K169	R:R:S101	9.18	No	No	0	3	4
101	R:R:P103	R:R:V102	3.53	No	No	0	5	3
102	R:R:C104	R:R:C173	7.28	No	No	0	9	9
103	R:R:T105	R:R:T167	9.42	No	No	0	8	4
104	R:R:T108	R:R:V166	7.93	No	No	0	6	5
105	R:R:A109	R:R:F163	5.55	No	Yes	0	5	4
106	R:R:F111	R:R:Y112	9.28	Yes	No	2	7	5
107	R:R:F111	R:R:F281	4.29	Yes	Yes	2	7	7
108	R:R:F116	R:R:Y112	3.09	Yes	No	2	7	5
109	R:R:H162	R:R:Y112	16.33	Yes	No	2	4	5
110	R:R:V113	R:R:V156	3.21	No	No	0	5	3
111	R:R:F116	R:R:M115	4.98	Yes	No	0	7	8
112	R:R:M115	R:R:W241	3.49	No	Yes	0	8	8
113	R:R:F116	R:R:I158	10.05	Yes	No	0	7	5
114	R:R:F116	R:R:H162	7.92	Yes	Yes	2	7	4
115	R:R:A117	R:R:W152	7.78	No	Yes	0	7	9
116	R:R:C120	R:R:W151	7.84	No	No	0	5	6
117	R:R:C120	R:R:F154	2.79	No	No	0	5	4
118	R:R:F121	R:R:S148	5.28	Yes	No	1	7	7
119	R:R:F121	R:R:W151	5.01	Yes	No	0	7	6
120	R:R:F121	R:R:W152	9.02	Yes	Yes	1	7	9
121	R:R:H283	R:R:I122	3.98	Yes	Yes	1	9	8
122	R:R:I122	R:R:N287	5.66	Yes	Yes	1	8	9
123	R:R:I122	R:R:Y291	7.25	Yes	Yes	1	8	9
124	R:R:L127	R:R:T123	2.95	No	No	7	6	7
125	R:R:P200	R:R:T123	3.5	No	No	0	9	7
126	R:R:T123	R:R:V203	3.17	No	No	7	7	6
127	R:R:E124	R:R:W151	14.17	No	No	0	6	6
128	R:R:I125	R:R:R129	6.26	No	No	0	8	9
129	R:R:I125	R:R:Y291	7.25	No	Yes	1	8	9
130	R:R:A126	R:R:I204	3.25	No	No	0	9	7
131	R:R:A126	R:R:C207	3.61	No	No	0	9	6
132	R:R:A126	R:R:Y208	6.67	No	Yes	0	9	8
133	R:R:L127	R:R:V203	2.98	No	No	7	6	6
134	R:R:R129	R:R:Y208	6.17	No	Yes	0	9	8
135	R:R:V134	R:R:Y130	8.83	Yes	Yes	3	7	8
136	R:R:Y130	R:R:Y135	5.96	Yes	No	3	8	6
137	R:R:Y130	R:R:Y206	4.96	Yes	No	3	8	3
138	R:R:C207	R:R:Y130	9.41	No	Yes	0	6	8
139	R:R:R210	R:R:Y130	7.2	No	Yes	3	3	8
140	R:R:A132	R:R:Y138	4	No	No	0	7	4
141	R:R:I133	R:R:V134	3.07	No	Yes	0	8	7
142	R:R:I133	R:R:I211	11.77	No	No	0	8	8
143	R:R:V134	R:R:Y135	8.83	Yes	No	3	7	6
144	R:R:I214	R:R:V134	3.07	No	Yes	0	5	7
145	R:R:P140	R:R:R139	4.32	No	No	8	6	7
146	R:R:Q143	R:R:R139	3.5	No	No	8	3	7
147	R:R:P140	R:R:Q143	6.32	No	No	8	6	3
148	R:R:F147	R:R:Q143	3.51	No	No	0	5	3
149	R:R:F150	R:R:L146	8.53	No	No	0	2	2
150	R:R:F154	R:R:I157	3.77	No	No	0	4	3
151	R:R:E191	R:R:I158	5.47	No	No	0	2	5
152	R:R:I160	R:R:P161	3.39	No	No	0	5	9
153	R:R:L188	R:R:P161	3.28	No	No	0	5	9
154	R:R:H162	R:R:L188	12.86	Yes	No	0	4	5
155	R:R:E191	R:R:H162	11.08	No	Yes	0	2	4
156	R:R:H162	R:R:L192	6.43	Yes	No	0	4	5
157	R:R:F163	R:R:M164	8.71	Yes	No	0	4	4
158	R:R:V165	R:R:Y177	6.31	No	Yes	9	5	5
159	R:R:L180	R:R:V165	2.98	Yes	No	9	3	5
160	R:R:D170	R:R:K168	11.06	No	No	10	1	4
161	R:R:D176	R:R:K168	16.59	Yes	No	10	4	4
162	R:R:D170	R:R:N171	4.04	No	No	0	1	5
163	R:R:D170	R:R:D176	6.65	No	Yes	10	1	4
164	R:R:M174	R:R:Q172	12.23	No	No	0	4	3
165	R:R:M174	R:R:T175	4.52	No	No	0	4	5
166	R:R:D176	R:R:M174	5.54	Yes	No	0	4	4
167	R:R:T175	R:R:Y177	17.48	No	Yes	0	5	5
168	R:R:L180	R:R:Y177	3.52	Yes	Yes	9	3	5
169	R:R:P185	R:R:Y177	20.86	No	Yes	0	3	5
170	R:R:L188	R:R:Y177	3.52	No	Yes	0	5	5
171	R:R:L180	R:R:Y179	4.69	Yes	No	0	3	1
172	R:R:L180	R:R:Y184	5.86	Yes	No	0	3	4
173	R:R:L255	R:R:P185	3.28	No	No	0	4	3
174	R:R:I186	R:R:T252	3.04	Yes	No	0	3	6
175	R:R:I186	R:R:L255	5.71	Yes	No	0	3	4
176	R:R:L248	R:R:N189	15.1	No	No	11	5	5
177	R:R:N189	R:R:T252	4.39	No	No	11	5	6
178	R:R:L248	R:R:M193	5.65	No	No	0	5	5
179	R:R:F249	R:R:M193	7.46	No	No	0	5	5
180	R:R:L194	R:R:V198	2.98	No	No	0	4	5
181	R:R:I199	R:R:L194	2.85	No	No	0	5	4
182	R:R:A196	R:R:H245	2.93	No	No	0	6	8
183	R:R:F197	R:R:L242	7.31	No	No	0	9	5
184	R:R:F197	R:R:H245	19.23	No	No	0	9	8
185	R:R:I199	R:R:P200	3.39	No	No	0	5	9
186	R:R:I204	R:R:L201	2.85	No	Yes	1	7	6
187	R:R:L201	R:R:S205	4.5	Yes	No	0	6	5
188	R:R:F237	R:R:L201	7.31	Yes	Yes	1	9	6
189	R:R:I238	R:R:L201	4.28	No	Yes	0	5	6
190	R:R:F237	R:R:I204	5.02	Yes	No	1	9	7
191	R:R:R210	R:R:Y206	13.38	No	No	3	3	3
192	R:R:L230	R:R:Y208	17.58	No	Yes	0	7	8
193	R:R:V233	R:R:Y208	3.79	No	Yes	0	7	8
194	R:R:R213	R:R:Y209	10.29	No	No	0	4	3
195	R:R:I211	R:R:L230	2.85	No	No	0	8	7
196	R:R:S212	R:R:V227	4.85	No	No	0	4	5
197	R:R:S218	R:R:V215	3.23	No	No	0	5	8
198	R:R:I226	R:R:V215	9.22	No	No	0	7	8
199	R:R:H222	R:R:R221	6.77	No	No	0	5	4
200	R:R:R225	R:R:R228	5.33	No	No	0	7	6
201	R:R:R225	R:R:R299	3.2	No	No	0	7	8
202	R:R:I231	R:R:V227	3.07	No	No	0	4	5
203	R:R:V229	R:R:V294	4.81	No	No	0	7	6
204	R:R:I231	R:R:L235	2.85	No	No	0	4	5
205	R:R:L290	R:R:V233	2.98	Yes	No	1	7	7
206	R:R:V233	R:R:Y291	5.05	No	Yes	1	7	9
207	R:R:I238	R:R:V234	3.07	No	No	0	5	8
208	R:R:F240	R:R:V236	3.93	Yes	No	0	7	6
209	R:R:L286	R:R:V236	2.98	No	No	1	7	6
210	R:R:L290	R:R:V236	7.45	Yes	No	1	7	6
211	R:R:F237	R:R:W241	8.02	Yes	Yes	1	9	8
212	R:R:F237	R:R:H283	3.39	Yes	Yes	1	9	9
213	R:R:I238	R:R:L242	2.85	No	No	0	5	5
214	R:R:F240	R:R:I239	6.28	Yes	No	0	7	5
215	R:R:F240	R:R:L279	4.87	Yes	No	0	7	7
216	R:R:C282	R:R:F240	2.79	No	Yes	0	6	7
217	R:R:H245	R:R:W241	4.23	No	Yes	0	8	8
218	R:R:H283	R:R:W241	13.75	Yes	Yes	1	9	8
219	R:R:L242	R:R:P243	3.28	No	No	0	5	9
220	R:R:P243	R:R:T276	3.5	No	No	0	9	6
221	R:R:L279	R:R:P243	3.28	No	No	0	7	9
222	R:R:E277	R:R:Y244	7.86	No	No	0	6	6
223	R:R:L273	R:R:T247	4.42	No	No	0	5	5
224	R:R:T247	R:R:T276	6.28	No	No	0	5	6
225	R:R:L248	R:R:T252	2.95	No	No	11	5	6
226	R:R:F249	R:R:L253	7.31	No	No	0	5	4
227	R:R:D251	R:R:K254	5.53	No	No	0	5	3
228	R:R:D251	R:R:L269	8.14	No	No	0	5	5
229	R:R:I259	R:R:L253	4.28	No	No	0	1	4
230	R:R:K254	R:R:S261	7.65	No	No	13	3	3
231	R:R:E266	R:R:K254	8.1	No	No	13	3	3
232	R:R:L256	R:R:W258	18.22	No	No	0	2	2
233	R:R:E266	R:R:S261	7.19	No	No	13	3	3
234	R:R:E277	R:R:F281	7	No	Yes	0	6	7
235	R:R:H283	R:R:N287	8.93	Yes	Yes	1	9	9
236	R:R:L286	R:R:L290	4.15	No	Yes	1	7	7
237	R:R:N287	R:R:Y291	3.49	Yes	Yes	1	9	9
238	R:R:F293	R:R:P288	2.89	Yes	Yes	1	7	9
239	R:R:L290	R:R:Y291	3.52	Yes	Yes	1	7	9
240	R:R:F293	R:R:V292	5.24	Yes	Yes	1	7	7
241	R:R:F298	R:R:V292	5.24	Yes	Yes	1	8	7
242	R:R:F293	R:R:L302	7.31	Yes	Yes	0	7	6
243	R:R:K297	R:R:T296	3	No	No	0	7	5
244	R:R:K297	R:R:Q300	9.49	No	No	0	7	5
245	R:R:Q300	R:R:R314	4.67	No	No	0	5	1
246	R:R:L302	R:R:L306	8.3	Yes	No	0	6	6
247	R:R:H303	R:R:L311	6.43	No	Yes	0	4	3
248	R:R:H303	R:R:R314	12.41	No	No	0	4	1
249	R:R:L306	R:R:L311	4.15	No	Yes	14	6	3
250	R:R:P313	R:R:V312	5.3	No	No	0	5	3
251	R:R:A159	R:R:F116	2.77	No	Yes	0	7	7
252	R:R:L269	R:R:L273	2.77	No	No	0	5	5
253	R:R:L80	R:R:N51	2.75	No	Yes	0	7	9
254	R:R:D176	R:R:D178	2.66	Yes	No	0	4	6
255	R:R:R271	R:R:S32	2.64	No	No	0	2	3
256	R:R:F265	R:R:S261	2.64	No	No	0	1	3
257	R:R:F265	R:R:S262	2.64	No	No	0	1	6
258	R:R:F46	R:R:V42	2.62	No	No	0	5	5
259	R:R:A78	R:R:W152	2.59	No	Yes	0	8	9
260	R:R:F163	R:R:T108	2.59	Yes	No	0	4	6
261	R:R:R225	R:R:T296	2.59	No	No	0	7	5
262	R:R:F163	R:R:I160	2.51	Yes	No	0	4	5
263	R:R:V113	R:R:W152	2.45	No	Yes	0	5	9
264	R:R:F121	R:R:L75	2.44	Yes	Yes	1	7	9
265	R:R:F237	R:R:L119	2.44	Yes	No	0	9	7
266	R:R:D128	R:R:R139	2.38	No	No	0	8	7
267	R:R:L127	R:R:Y131	2.34	No	No	0	6	5
268	R:R:F147	R:R:F150	2.14	No	No	0	5	2
269	R:R:F309	R:R:R310	2.14	No	No	0	4	3
270	R:R:G50	R:R:P288	2.03	No	Yes	0	7	9
271	R:R:F111	R:R:W89	2	Yes	No	2	7	7
272	R:R:Y131	R:R:Y135	1.99	No	No	0	5	6
273	R:R:C66	R:R:G68	1.96	No	No	0	7	7
274	R:R:G295	R:R:V294	1.84	No	No	0	8	6
275	R:R:A155	R:R:C120	1.81	No	No	0	7	5
276	R:R:G224	R:R:K223	1.74	No	No	0	6	7
277	R:R:C173	R:R:V166	1.71	No	No	0	9	5
278	R:R:G195	R:R:L194	1.71	No	No	0	3	4
279	R:R:C110	R:R:T85	1.69	No	No	0	4	7
280	R:R:A272	R:R:T247	1.68	No	No	0	4	5
281	R:R:S218	R:R:S220	1.63	No	No	12	5	4
282	R:R:S48	R:R:V83	1.62	No	No	0	5	6
283	R:R:S101	R:R:V102	1.62	No	No	0	4	3
284	R:R:C145	R:R:K142	1.62	No	No	0	4	3
285	R:R:S202	R:R:V198	1.62	No	No	0	3	5
286	R:R:I186	R:R:V190	1.54	Yes	No	0	3	4
287	R:R:I211	R:R:V215	1.54	No	No	0	8	8
288	R:R:K223	R:R:S218	1.53	No	No	12	7	5
289	R:R:K223	R:R:S220	1.53	No	No	12	7	4
290	R:R:I274	R:R:T36	1.52	No	No	0	5	5
291	R:R:I55	R:R:T59	1.52	No	No	1	7	2
292	R:R:I58	R:R:T59	1.52	Yes	No	1	6	2
293	R:R:I73	R:R:T59	1.52	Yes	No	1	5	2
294	R:R:F298	R:R:G295	1.51	Yes	No	0	8	8
295	R:R:N97	R:R:S98	1.49	No	No	0	9	3
296	R:R:L255	R:R:V182	1.49	No	No	0	4	1
297	R:R:L269	R:R:V250	1.49	No	No	0	5	5
298	R:R:L311	R:R:V312	1.49	Yes	No	0	3	3
299	R:R:I149	R:R:I153	1.47	No	No	0	4	3
300	R:R:I153	R:R:I157	1.47	No	No	0	3	3
301	R:R:N30	R:R:T26	1.46	No	No	0	4	4
302	R:R:E264	R:R:S262	1.44	No	No	0	4	6
303	R:R:I186	R:R:L256	1.43	Yes	No	0	3	2
304	R:R:H222	R:R:S220	1.39	No	No	0	5	4
305	R:R:L37	R:R:L94	1.38	Yes	No	0	4	5
306	R:R:L286	R:R:L289	1.38	No	No	0	7	6
307	R:R:A77	R:R:W152	1.3	No	Yes	0	5	9
308	R:R:F163	R:R:T105	1.3	Yes	No	0	4	8
309	R:R:A280	R:R:W241	1.3	No	Yes	0	8	8
310	R:R:S212	R:R:Y209	1.27	No	No	0	4	3
311	R:R:F38	R:R:L39	1.22	No	No	0	5	5
312	R:R:L306	R:R:R310	1.21	No	No	14	6	3
313	R:R:L311	R:R:R310	1.21	Yes	No	14	3	3
314	R:R:M136	R:R:Y138	1.2	No	No	0	4	4
315	R:R:Q31	R:R:R271	1.17	No	No	0	4	2
316	R:R:E308	R:R:F309	1.17	No	No	0	4	4
317	R:R:R137	R:R:Y131	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K33	4.3575	4	5	4
2	R:R:L37	3.84	4	5	4
3	R:R:Y40	6.4775	4	2	7
4	R:R:N51	6.605	4	0	9
5	R:R:V54	5.1175	4	1	9
6	R:R:I58	4.7825	4	1	6
7	R:R:R62	5.9725	4	1	5
8	R:R:D69	4.2125	4	1	8
9	R:R:V70	3.675	4	1	6
10	R:R:F72	4.66	4	1	8
11	R:R:I73	3.3225	4	1	5
12	R:R:N74	8.6175	4	1	9
13	R:R:L75	4.966	5	1	9
14	R:R:D79	6.132	5	1	9
15	R:R:F111	5.5	4	2	7
16	R:R:F116	5.762	5	2	7
17	R:R:F121	7.734	5	1	7
18	R:R:I122	5.65	4	1	8
19	R:R:Y130	7.272	5	3	8
20	R:R:V134	5.95	4	3	7
21	R:R:W152	4.79833	6	1	9
22	R:R:H162	10.924	5	2	4
23	R:R:F163	4.132	5	0	4
24	R:R:D176	7.86	4	10	4
25	R:R:Y177	10.338	5	9	5
26	R:R:L180	4.2625	4	9	3
27	R:R:I186	2.93	4	0	3
28	R:R:L201	4.735	4	1	6
29	R:R:Y208	8.5525	4	0	8
30	R:R:F237	5.236	5	1	9
31	R:R:F240	4.4675	4	0	7
32	R:R:W241	6.158	5	1	8
33	R:R:F281	7.575	4	2	7
34	R:R:H283	7.5125	4	1	9
35	R:R:N287	6.884	5	1	9
36	R:R:P288	4.555	4	1	9
37	R:R:L290	4.525	4	1	7
38	R:R:Y291	5.28667	6	1	9
39	R:R:V292	6.335	4	1	7
40	R:R:F293	4.8425	4	1	7
41	R:R:F298	3.985	4	1	8
42	R:R:L302	6.7625	4	0	6
43	R:R:L311	3.32	4	14	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R271	R:R:S32	11.7493	2.64	No	No	0	2	3
2	R:R:I274	R:R:S32	13.3935	3.1	No	No	0	5	3
3	R:R:I274	R:R:T36	14.9255	1.52	No	No	0	5	5
4	R:R:T36	R:R:Y40	16.5003	8.74	No	Yes	2	5	7
5	R:R:F281	R:R:Y40	33.6412	7.22	Yes	Yes	2	7	7
6	R:R:F111	R:R:F281	15.075	4.29	Yes	Yes	2	7	7
7	R:R:F111	R:R:Y112	44.9955	9.28	Yes	No	2	7	5
8	R:R:H162	R:R:Y112	35.1359	16.33	Yes	No	2	4	5
9	R:R:H162	R:R:L188	98.0729	12.86	Yes	No	0	4	5
10	R:R:L188	R:R:Y177	56.5686	3.52	No	Yes	0	5	5
11	R:R:T175	R:R:Y177	21.8491	17.48	No	Yes	0	5	5
12	R:R:M174	R:R:T175	19.906	4.52	No	No	0	4	5
13	R:R:M90	R:R:Y40	15.0323	3.59	No	Yes	0	7	7
14	R:R:L37	R:R:M90	11.7653	2.83	Yes	No	0	4	7
15	R:R:F281	R:R:F82	22.9969	11.79	Yes	No	2	7	7
16	R:R:C284	R:R:F82	55.4263	4.19	No	No	0	8	7
17	R:R:C284	R:R:D79	56.1256	4.67	No	Yes	0	8	9
18	R:R:D79	R:R:N287	25.2496	6.73	Yes	Yes	1	9	9
19	R:R:N287	R:R:Y291	45.4279	3.49	Yes	Yes	1	9	9
20	R:R:L290	R:R:Y291	36.5451	3.52	Yes	Yes	1	7	9
21	R:R:L290	R:R:V236	35.1252	7.45	Yes	No	1	7	6
22	R:R:F240	R:R:V236	33.7159	3.93	Yes	No	0	7	6
23	R:R:C282	R:R:F240	21.4221	2.79	No	Yes	0	6	7
24	R:R:C282	R:R:V43	19.084	3.42	No	No	0	6	7
25	R:R:L86	R:R:V43	12.0056	2.98	No	No	0	8	7
26	R:R:D79	R:R:N51	38.0985	10.77	Yes	Yes	0	9	9
27	R:R:N51	R:R:P288	26.4346	9.77	Yes	Yes	0	9	9
28	R:R:F293	R:R:P288	23.0823	2.89	Yes	Yes	1	7	9
29	R:R:F293	R:R:L302	39.5025	7.31	Yes	Yes	0	7	6
30	R:R:L302	R:R:T57	12.2137	5.9	Yes	No	0	6	6
31	R:R:F293	R:R:V292	21.4007	5.24	Yes	Yes	1	7	7
32	R:R:F72	R:R:Y291	41.1413	5.16	Yes	Yes	1	8	9
33	R:R:F72	R:R:V292	25.4951	5.24	Yes	Yes	1	8	7
34	R:R:F298	R:R:F72	23.4292	3.22	Yes	Yes	1	8	8
35	R:R:D69	R:R:F298	16.7085	5.97	Yes	Yes	1	8	8
36	R:R:D79	R:R:L75	25.4631	4.07	Yes	Yes	1	9	9
37	R:R:F121	R:R:L75	100	2.44	Yes	Yes	1	7	9
38	R:R:F121	R:R:W151	50.9422	5.01	Yes	No	0	7	6
39	R:R:E124	R:R:W151	30.2034	14.17	No	No	0	6	6
40	R:R:E124	R:R:Y71	27.246	15.71	No	No	0	6	7
41	R:R:D128	R:R:Y71	24.7157	9.2	No	No	0	8	7
42	R:R:F121	R:R:N74	14.8828	16.92	Yes	Yes	1	7	9
43	R:R:N74	R:R:V70	12.3792	2.96	Yes	Yes	1	9	6
44	R:R:F121	R:R:S148	14.9149	5.28	Yes	No	1	7	7
45	R:R:S148	R:R:V70	11.9628	3.23	No	Yes	1	7	6
46	R:R:C145	R:R:V70	12.1443	3.42	No	Yes	0	4	6
47	R:R:F121	R:R:W152	18.2512	9.02	Yes	Yes	1	7	9
48	R:R:I122	R:R:L75	39.6893	5.71	Yes	Yes	1	8	9
49	R:R:L188	R:R:P161	48.0382	3.28	No	No	0	5	9
50	R:R:I160	R:R:P161	46.2446	3.39	No	No	0	5	9
51	R:R:F163	R:R:I160	44.4403	2.51	Yes	No	0	4	5
52	R:R:F163	R:R:T108	35.2586	2.59	Yes	No	0	4	6
53	R:R:T108	R:R:V166	33.3903	7.93	No	No	0	6	5
54	R:R:C173	R:R:V166	31.5112	1.71	No	No	0	9	5
55	R:R:C173	R:R:Y92	15.8063	4.03	No	No	0	9	6
56	R:R:L99	R:R:Y92	11.9201	8.21	No	No	0	7	6
57	R:R:C104	R:R:C173	13.8312	7.28	No	No	0	9	9
58	R:R:C104	R:R:L99	11.8881	6.35	No	No	0	9	7
59	R:R:L99	R:R:P103	19.8527	3.28	No	No	0	7	5
60	R:R:P103	R:R:V102	11.9415	3.53	No	No	0	5	3
61	R:R:F116	R:R:Y112	10.1158	3.09	Yes	No	2	7	5
62	R:R:F116	R:R:M115	80.6011	4.98	Yes	No	0	7	8
63	R:R:M115	R:R:W241	81.6847	3.49	No	Yes	0	8	8
64	R:R:C120	R:R:W151	18.5074	7.84	No	No	0	5	6
65	R:R:C120	R:R:F154	12.3792	2.79	No	No	0	5	4
66	R:R:H283	R:R:N287	50.1735	8.93	Yes	Yes	1	9	9
67	R:R:F237	R:R:H283	27.2994	3.39	Yes	Yes	1	9	9
68	R:R:F237	R:R:I204	28.7194	5.02	Yes	No	1	9	7
69	R:R:A126	R:R:I204	31.5112	3.25	No	No	0	9	7
70	R:R:A126	R:R:C207	45.3852	3.61	No	No	0	9	6
71	R:R:C207	R:R:Y130	42.983	9.41	No	Yes	0	6	8
72	R:R:Y130	R:R:Y135	30.166	5.96	Yes	No	3	8	6
73	R:R:Y131	R:R:Y135	28.4738	1.99	No	No	0	5	6
74	R:R:L127	R:R:Y131	23.3919	2.34	No	No	0	6	5
75	R:R:F237	R:R:W241	19.2441	8.02	Yes	Yes	1	9	8
76	R:R:V233	R:R:Y291	30.5824	5.05	No	Yes	1	7	9
77	R:R:V233	R:R:Y208	33.2141	3.79	No	Yes	0	7	8
78	R:R:A126	R:R:Y208	30.5877	6.67	No	Yes	0	9	8
79	R:R:L127	R:R:T123	18.2299	2.95	No	No	7	6	7
80	R:R:P200	R:R:T123	15.6889	3.5	No	No	0	9	7
81	R:R:I125	R:R:R129	10.9806	6.26	No	No	0	8	9
82	R:R:L230	R:R:Y208	23.0129	17.58	No	Yes	0	7	8
83	R:R:I211	R:R:L230	21.2673	2.85	No	No	0	8	7
84	R:R:D128	R:R:R139	18.6035	2.38	No	No	0	8	7
85	R:R:Q143	R:R:R139	12.4219	3.5	No	No	8	3	7
86	R:R:D176	R:R:M174	10.1372	5.54	Yes	No	0	4	4
87	R:R:P185	R:R:Y177	27.6197	20.86	No	Yes	0	3	5
88	R:R:L255	R:R:P185	25.698	3.28	No	No	0	4	3
89	R:R:I186	R:R:L255	21.9399	5.71	Yes	No	0	3	4
90	R:R:I186	R:R:T252	14.1195	3.04	Yes	No	0	3	6
91	R:R:L248	R:R:T252	10.1105	2.95	No	No	11	5	6
92	R:R:I199	R:R:P200	13.0999	3.39	No	No	0	5	9
93	R:R:I199	R:R:L194	10.5002	2.85	No	No	0	5	4
94	R:R:H245	R:R:W241	25.3136	4.23	No	Yes	0	8	8
95	R:R:F197	R:R:H245	21.9506	19.23	No	No	0	9	8
96	R:R:F197	R:R:L242	20.5039	7.31	No	No	0	9	5
97	R:R:F237	R:R:L201	14.744	7.31	Yes	Yes	1	9	6
98	R:R:I238	R:R:L201	15.0163	4.28	No	Yes	0	5	6
99	R:R:I211	R:R:V215	15.8384	1.54	No	No	0	8	8
100	R:R:S218	R:R:V215	11.9415	3.23	No	No	0	5	8
101	R:R:L302	R:R:L306	26.9685	8.3	Yes	No	0	6	6
102	R:R:L306	R:R:L311	19.81	4.15	No	Yes	14	6	3
103	R:R:H303	R:R:L311	14.6373	6.43	No	Yes	0	4	3
104	R:R:H303	R:R:R314	12.833	12.41	No	No	0	4	1
105	R:R:Q300	R:R:R314	11.0127	4.67	No	No	0	5	1
106	R:R:F240	R:R:L279	18.5662	4.87	Yes	No	0	7	7
107	R:R:L242	R:R:P243	29.0877	3.28	No	No	0	5	9
108	R:R:P243	R:R:T276	33.6518	3.5	No	No	0	9	6
109	R:R:T247	R:R:T276	31.1269	6.28	No	No	0	5	6
110	R:R:L273	R:R:T247	26.0449	4.42	No	No	0	5	5
111	R:R:L269	R:R:L273	23.488	2.77	No	No	0	5	5
112	R:R:D251	R:R:L269	18.3313	8.14	No	No	0	5	5
113	R:R:D251	R:R:K254	15.7476	5.53	No	No	0	5	3
114	R:R:K254	R:R:S261	10.5215	7.65	No	No	13	3	3
115	R:R:F116	R:R:H162	66.6951	7.92	Yes	Yes	2	7	4
116	R:R:L279	R:R:P243	18.027	3.28	No	No	0	7	9
117	R:R:H283	R:R:W241	62.0242	13.75	Yes	Yes	1	9	8
118	R:R:H283	R:R:I122	39.8868	3.98	Yes	Yes	1	9	8
119	R:R:I122	R:R:Y291	31.2497	7.25	Yes	Yes	1	8	9
120	R:R:F111	R:R:F82	31.8262	6.43	Yes	No	2	7	7
121	R:R:L75	R:R:N287	39.4438	9.61	Yes	Yes	1	9	9
122	R:R:R129	R:R:Y208	10.0144	6.17	No	Yes	0	9	8
123	R:R:I238	R:R:L242	11.5144	2.85	No	No	0	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5WB1

PDB Summary
PDB	5WB1
Class	A
SubFamily	Other
Type	Unclassified
SubType	US28
Species	Human cytomegalovirus (strain Towne)
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.51
Date	2018-06-13
D.O.I.	10.7554/eLife.35850

Net Summary
I_min	2.79
Number of Linked Nodes	273
Number of Links	317
Number of Hubs	43
Number of Links mediated by Hubs	145
Number of Communities	14
Number of Nodes involved in Communities	83
Number of Links involved in Communities	105

Path Summary
Number Of Nodes in MetaPath	124
Number Of Links MetaPath	123
Number of Shortest Paths	56067
Length Of Smallest Path	3
Average Path Length	14.1738
Length of Longest Path	32
Minimum Path Strength	1.35
Average Path Strength	5.93598
Maximum Path Strength	19.17
Minimum Path Correlation	0.7
Average Path Correlation	0.933478
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	50.5649
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.7731
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P69333
Sequence	>5WB1_Chain_R P C V F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R R R I Q C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D H N S L A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y M R Y R P V K Q A C L F S I F W W I F A V I I A I P H F M V V T K K D N Q C M T D Y D Y L E V S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S Q S R H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K W I S S S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K F R Q E L H C L L A E F R L V P R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4XT1	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	2.89	2015-03-04	10.1126/science.aaa5026
	4XT3	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	3.8	2015-03-04	10.1126/science.aaa5026
	5WB1	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	-	-	-	3.51	2018-06-13	10.7554/eLife.35850
	5WB2	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	CX3CL1.35	-	-	3.5	2018-06-13	10.7554/eLife.35850
	7RKF	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP	chim(NtGi1-G11)/&β;1/&γ;2	4	2022-01-26	10.1126/sciadv.abl5442
	7RKM	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/&β;1/&γ;2	3.5	2022-01-26	10.1126/sciadv.abl5442
	7RKN	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/&β;1/&γ;2	3.6	2022-01-26	10.1126/sciadv.abl5442

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5WB1.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.