psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	5.5	No	Yes	1	0	0
2	L:L:?1	R:R:W89	6.09	No	Yes	1	0	7
3	L:L:?1	R:R:V166	3.19	No	No	0	0	5
4	L:L:G4	L:L:H2	3.18	No	Yes	1	0	0
5	L:L:H2	L:L:V5	8.3	Yes	No	1	0	0
6	L:L:H2	R:R:Y40	4.36	Yes	Yes	0	0	7
7	L:L:H2	R:R:W89	4.23	Yes	Yes	1	0	7
8	L:L:H2	R:R:F111	10.18	Yes	Yes	1	0	7
9	L:L:H2	R:R:E277	11.08	Yes	Yes	1	0	6
10	L:L:H3	R:R:N189	5.1	No	No	1	0	5
11	L:L:H3	R:R:L248	3.86	No	Yes	1	0	5
12	L:L:H3	R:R:L273	11.57	No	No	1	0	5
13	L:L:G4	R:R:I274	5.29	No	No	0	0	5
14	L:L:G4	R:R:E277	3.27	No	Yes	1	0	6
15	L:L:V5	R:R:W89	9.81	No	Yes	1	0	7
16	L:L:T6	R:R:L29	2.95	No	No	0	0	3
17	L:L:T6	R:R:K270	9.01	No	No	0	0	4
18	L:L:K7	L:L:S33	4.59	No	No	0	0	0
19	L:L:K7	R:R:Y92	3.58	No	No	0	0	6
20	L:L:C8	L:L:I10	3.27	No	Yes	6	0	0
21	L:L:C34	L:L:C8	7.28	No	No	6	0	0
22	L:L:N9	L:L:Q31	6.6	Yes	No	0	0	0
23	L:L:N9	R:R:V24	2.96	Yes	No	8	0	2
24	L:L:N9	R:R:F25	3.62	Yes	No	0	0	3
25	L:L:N9	R:R:T26	2.92	Yes	No	8	0	4
26	L:L:I10	L:L:N30	9.91	Yes	No	0	0	0
27	L:L:C34	L:L:I10	3.27	No	Yes	6	0	0
28	L:L:I10	L:L:I40	2.94	Yes	Yes	6	0	0
29	L:L:T11	R:R:C23	6.76	No	No	0	0	8
30	L:L:C12	L:L:C50	7.28	No	No	0	0	0
31	L:L:K14	R:R:D19	2.77	Yes	No	5	0	4
32	L:L:K14	R:R:A20	4.82	Yes	No	5	0	4
33	L:L:D52	L:L:M15	8.32	No	No	0	0	0
34	L:L:F49	L:L:T16	3.89	Yes	No	5	0	0
35	L:L:T16	R:R:E18	11.29	No	Yes	5	0	3
36	L:L:S17	R:R:E18	2.87	No	Yes	0	0	3
37	L:L:I19	L:L:P20	3.39	Yes	No	0	0	0
38	L:L:I19	L:L:L24	5.71	Yes	No	0	0	0
39	L:L:I19	R:R:Y16	4.84	Yes	No	5	0	5
40	L:L:I19	R:R:E18	5.47	Yes	Yes	5	0	3
41	L:L:V21	L:L:W57	6.13	No	Yes	0	0	0
42	L:L:L23	L:L:T43	2.95	No	Yes	0	0	0
43	L:L:L24	L:L:L41	6.92	No	No	0	0	0
44	L:L:L24	L:L:T43	2.95	No	Yes	0	0	0
45	L:L:I25	L:L:R44	20.04	No	No	0	0	0
46	L:L:E42	L:L:H26	8.62	No	No	0	0	0
47	L:L:H26	L:L:L65	6.43	No	No	0	0	0
48	L:L:I39	L:L:Y27	4.84	No	Yes	0	0	0
49	L:L:V58	L:L:Y27	8.83	No	Yes	0	0	0
50	L:L:N30	L:L:Q29	3.96	No	No	0	0	0
51	L:L:Q29	L:L:R37	11.68	No	No	0	0	0
52	L:L:A38	L:L:N30	3.13	No	No	0	0	0
53	L:L:A32	L:L:R37	2.77	No	No	0	0	0
54	L:L:S33	R:R:Q172	7.22	No	Yes	0	0	3
55	L:L:K36	R:R:D178	6.91	No	No	0	0	6
56	L:L:I39	L:L:P53	5.08	No	No	0	0	0
57	L:L:I40	L:L:L48	4.28	Yes	No	0	0	0
58	L:L:C50	L:L:I40	3.27	No	Yes	6	0	0
59	L:L:I40	R:R:P22	5.08	Yes	Yes	6	0	3
60	L:L:Q45	L:L:T43	4.25	No	Yes	9	0	0
61	L:L:R47	L:L:T43	3.88	No	Yes	9	0	0
62	L:L:Q45	L:L:R44	3.5	No	No	0	0	0
63	L:L:Q45	L:L:R47	9.35	No	No	9	0	0
64	L:L:H46	L:L:L48	3.86	No	No	0	0	0
65	L:L:F49	R:R:E18	4.66	Yes	Yes	5	0	3
66	L:L:F49	R:R:T21	5.19	Yes	No	0	0	3
67	L:L:C50	R:R:P22	3.77	No	Yes	6	0	3
68	L:L:D52	L:L:P53	11.27	No	No	0	0	0
69	L:L:D52	L:L:K54	6.91	No	No	0	0	0
70	L:L:E55	L:L:K54	14.85	No	No	0	0	0
71	L:L:E55	L:L:W57	17.45	No	Yes	0	0	0
72	L:L:Q56	L:L:W57	6.57	No	Yes	0	0	0
73	L:L:K59	L:L:Q56	2.71	No	No	0	0	0
74	L:L:D60	L:L:Q63	11.75	No	No	0	0	0
75	L:L:A61	L:L:H64	2.93	No	No	0	0	0
76	L:L:M62	L:L:Q63	2.72	No	No	0	0	0
77	L:L:D66	L:L:M62	6.93	No	No	0	0	0
78	R:R:D15	R:R:Y16	9.2	No	No	0	4	5
79	R:R:E18	R:R:Y16	5.61	Yes	No	5	3	5
80	R:R:A20	R:R:D19	3.09	No	No	5	4	4
81	R:R:P22	R:R:T21	5.25	Yes	No	0	3	3
82	R:R:C23	R:R:C263	7.28	No	No	0	8	6
83	R:R:T26	R:R:V24	6.35	No	No	8	4	2
84	R:R:D27	R:R:V28	5.84	No	No	0	3	4
85	R:R:L29	R:R:S32	3	No	No	0	3	3
86	R:R:K33	R:R:N30	6.99	No	No	0	4	4
87	R:R:I274	R:R:S32	4.64	No	No	0	5	3
88	R:R:K33	R:R:L93	2.82	No	No	0	4	6
89	R:R:T36	R:R:Y40	8.74	No	Yes	0	5	7
90	R:R:I274	R:R:T36	4.56	No	No	0	5	5
91	R:R:S278	R:R:T36	3.2	No	No	0	5	5
92	R:R:L37	R:R:L93	5.54	No	No	0	4	6
93	R:R:L37	R:R:L94	5.54	No	No	0	4	5
94	R:R:F38	R:R:V42	7.87	No	No	0	5	5
95	R:R:L39	R:R:S278	4.5	No	No	0	5	5
96	R:R:L86	R:R:Y40	5.86	No	Yes	0	8	7
97	R:R:M90	R:R:Y40	3.59	No	Yes	0	7	7
98	R:R:F281	R:R:Y40	6.19	Yes	Yes	0	7	7
99	R:R:L86	R:R:V43	2.98	No	No	0	8	7
100	R:R:F44	R:R:S48	3.96	No	No	0	6	5
101	R:R:F44	R:R:P87	18.78	No	No	0	6	9
102	R:R:F46	R:R:L45	4.87	No	No	0	5	5
103	R:R:C285	R:R:F46	5.59	No	No	0	7	5
104	R:R:G47	R:R:V83	3.68	No	No	0	8	6
105	R:R:N51	R:R:V54	2.96	Yes	Yes	0	9	9
106	R:R:D79	R:R:N51	4.04	Yes	Yes	0	9	9
107	R:R:L80	R:R:N51	2.75	No	Yes	0	7	9
108	R:R:N51	R:R:P288	6.52	Yes	No	0	9	9
109	R:R:F52	R:R:F56	13.93	No	No	0	2	3
110	R:R:V292	R:R:V54	4.81	Yes	Yes	3	7	9
111	R:R:F293	R:R:V54	3.93	Yes	Yes	3	7	9
112	R:R:E301	R:R:T57	4.23	No	No	0	4	6
113	R:R:L302	R:R:T57	4.42	No	No	0	6	6
114	R:R:I58	R:R:R62	5.01	Yes	Yes	3	6	5
115	R:R:D69	R:R:I58	11.2	Yes	Yes	3	8	6
116	R:R:I58	R:R:I73	2.94	Yes	No	0	6	5
117	R:R:F298	R:R:I58	5.02	Yes	Yes	3	8	6
118	R:R:I73	R:R:T59	3.04	No	No	0	5	2
119	R:R:R61	R:R:W60	14.99	No	No	0	5	4
120	R:R:L305	R:R:W60	3.42	No	No	0	4	4
121	R:R:E301	R:R:R61	3.49	No	No	0	4	5
122	R:R:Q65	R:R:R62	5.84	No	Yes	3	6	5
123	R:R:D69	R:R:R62	5.96	Yes	Yes	3	8	5
124	R:R:F298	R:R:R62	5.34	Yes	Yes	3	8	5
125	R:R:I64	R:R:V70	3.07	No	Yes	0	6	6
126	R:R:I64	R:R:I73	5.89	No	No	0	6	5
127	R:R:C66	R:R:Q65	6.1	No	No	3	7	6
128	R:R:D69	R:R:Q65	3.92	Yes	No	3	8	6
129	R:R:C66	R:R:S67	3.44	No	No	0	7	6
130	R:R:C66	R:R:D69	4.67	No	Yes	3	7	8
131	R:R:G68	R:R:S67	3.71	No	No	0	7	6
132	R:R:D128	R:R:S67	5.89	Yes	No	0	8	6
133	R:R:A144	R:R:V70	5.09	No	Yes	0	8	6
134	R:R:C145	R:R:V70	3.42	No	Yes	0	4	6
135	R:R:E124	R:R:Y71	17.96	Yes	Yes	0	6	7
136	R:R:I125	R:R:Y71	3.63	Yes	Yes	0	8	7
137	R:R:D128	R:R:Y71	10.34	Yes	Yes	0	8	7
138	R:R:A144	R:R:Y71	4	No	Yes	0	8	7
139	R:R:F72	R:R:I125	6.28	No	Yes	0	8	8
140	R:R:F72	R:R:V292	6.55	No	Yes	0	8	7
141	R:R:F121	R:R:N74	10.87	Yes	No	7	7	9
142	R:R:N74	R:R:S148	8.94	No	No	7	9	7
143	R:R:N74	R:R:W152	4.52	No	Yes	7	9	9
144	R:R:D79	R:R:L75	5.43	Yes	No	2	9	9
145	R:R:I122	R:R:L75	2.85	No	No	2	8	9
146	R:R:L75	R:R:N287	6.87	No	Yes	2	9	9
147	R:R:D79	R:R:S118	4.42	Yes	No	0	9	9
148	R:R:C284	R:R:D79	3.11	No	Yes	0	8	9
149	R:R:D79	R:R:N287	6.73	Yes	Yes	2	9	9
150	R:R:F111	R:R:F82	7.5	Yes	Yes	1	7	7
151	R:R:F281	R:R:F82	13.93	Yes	Yes	1	7	7
152	R:R:C284	R:R:F82	5.59	No	Yes	0	8	7
153	R:R:L86	R:R:T85	2.95	No	Yes	0	8	7
154	R:R:L107	R:R:T85	2.95	Yes	Yes	0	5	7
155	R:R:F111	R:R:T85	10.38	Yes	Yes	0	7	7
156	R:R:L107	R:R:L88	4.15	Yes	No	0	5	6
157	R:R:W89	R:R:Y92	3.86	Yes	No	0	7	6
158	R:R:L107	R:R:W89	13.67	Yes	Yes	0	5	7
159	R:R:F111	R:R:W89	4.01	Yes	Yes	1	7	7
160	R:R:H96	R:R:L99	3.86	No	No	0	5	7
161	R:R:N97	R:R:S98	4.47	No	No	0	9	3
162	R:R:N171	R:R:N97	4.09	No	No	0	5	9
163	R:R:L99	R:R:S98	3	No	No	0	7	3
164	R:R:P103	R:R:V102	5.3	No	No	0	5	3
165	R:R:L107	R:R:V102	2.98	Yes	No	0	5	3
166	R:R:C104	R:R:K168	6.47	No	No	10	9	4
167	R:R:C104	R:R:C173	7.28	No	No	10	9	9
168	R:R:T108	R:R:Y112	4.99	No	Yes	0	6	5
169	R:R:A109	R:R:F163	6.93	No	No	0	5	4
170	R:R:F111	R:R:Y112	3.09	Yes	Yes	1	7	5
171	R:R:F111	R:R:F281	6.43	Yes	Yes	1	7	7
172	R:R:F116	R:R:Y112	3.09	Yes	Yes	1	7	5
173	R:R:H162	R:R:Y112	18.51	Yes	Yes	1	4	5
174	R:R:L119	R:R:M115	2.83	No	No	0	7	8
175	R:R:F116	R:R:I158	6.28	Yes	Yes	0	7	5
176	R:R:A159	R:R:F116	2.77	No	Yes	0	7	7
177	R:R:F116	R:R:H162	3.39	Yes	Yes	1	7	4
178	R:R:A117	R:R:F121	2.77	No	Yes	7	7	7
179	R:R:A117	R:R:W152	6.48	No	Yes	7	7	9
180	R:R:A196	R:R:L119	3.15	No	No	0	6	7
181	R:R:L119	R:R:W241	3.42	No	Yes	0	7	8
182	R:R:C120	R:R:W151	9.14	No	Yes	0	5	6
183	R:R:F121	R:R:S148	6.61	Yes	No	7	7	7
184	R:R:F121	R:R:W151	7.02	Yes	Yes	0	7	6
185	R:R:F121	R:R:W152	10.02	Yes	Yes	7	7	9
186	R:R:I122	R:R:N287	4.25	No	Yes	2	8	9
187	R:R:I122	R:R:Y291	7.25	No	Yes	2	8	9
188	R:R:L127	R:R:T123	2.95	No	No	11	6	7
189	R:R:P200	R:R:T123	3.5	No	No	0	9	7
190	R:R:T123	R:R:V203	4.76	No	No	11	7	6
191	R:R:E124	R:R:R139	3.49	Yes	Yes	0	6	7
192	R:R:E124	R:R:W151	15.27	Yes	Yes	0	6	6
193	R:R:I125	R:R:R129	6.26	Yes	No	2	8	9
194	R:R:I125	R:R:Y291	6.04	Yes	Yes	2	8	9
195	R:R:A126	R:R:I204	3.25	No	No	0	9	7
196	R:R:A126	R:R:Y208	6.67	No	Yes	0	9	8
197	R:R:L127	R:R:V203	2.98	No	No	11	6	6
198	R:R:D128	R:R:R139	7.15	Yes	Yes	0	8	7
199	R:R:R129	R:R:Y208	5.14	No	Yes	2	9	8
200	R:R:R129	R:R:Y291	8.23	No	Yes	2	9	9
201	R:R:Y130	R:R:Y131	2.98	Yes	No	4	8	5
202	R:R:V134	R:R:Y130	11.36	No	Yes	4	7	8
203	R:R:Y130	R:R:Y135	5.96	Yes	No	4	8	6
204	R:R:Y130	R:R:Y206	4.96	Yes	No	4	8	3
205	R:R:C207	R:R:Y130	9.41	No	Yes	0	6	8
206	R:R:R210	R:R:Y130	9.26	No	Yes	4	3	8
207	R:R:Y131	R:R:Y135	3.97	No	No	4	5	6
208	R:R:R139	R:R:Y131	11.32	Yes	No	4	7	5
209	R:R:I133	R:R:I211	10.3	No	Yes	0	8	8
210	R:R:V134	R:R:Y135	10.09	No	No	4	7	6
211	R:R:I214	R:R:V134	4.61	No	No	0	5	7
212	R:R:R137	R:R:R139	10.66	No	Yes	0	4	7
213	R:R:Q143	R:R:R139	5.84	No	Yes	4	3	7
214	R:R:F147	R:R:R139	6.41	No	Yes	4	5	7
215	R:R:P140	R:R:Q143	14.21	No	No	0	6	3
216	R:R:F147	R:R:Q143	14.05	No	No	4	5	3
217	R:R:F150	R:R:W151	4.01	No	Yes	0	2	6
218	R:R:F154	R:R:W151	7.02	No	Yes	0	4	6
219	R:R:F154	R:R:I158	6.28	No	Yes	0	4	5
220	R:R:E191	R:R:I158	5.47	No	Yes	0	2	5
221	R:R:A159	R:R:F163	2.77	No	No	0	7	4
222	R:R:I160	R:R:P161	3.39	No	Yes	0	5	9
223	R:R:F163	R:R:I160	6.28	No	No	0	4	5
224	R:R:I160	R:R:M164	5.83	No	No	0	5	4
225	R:R:H162	R:R:P161	6.1	Yes	Yes	0	4	9
226	R:R:P161	R:R:Y184	2.78	Yes	Yes	0	9	4
227	R:R:E191	R:R:P161	3.14	No	Yes	0	2	9
228	R:R:H162	R:R:L188	10.29	Yes	No	0	4	5
229	R:R:H162	R:R:L192	5.14	Yes	No	1	4	5
230	R:R:T175	R:R:V165	3.17	No	No	0	5	5
231	R:R:V165	R:R:Y184	3.79	No	Yes	0	5	4
232	R:R:M174	R:R:T167	3.01	No	No	0	4	4
233	R:R:C173	R:R:K168	3.23	No	No	10	9	4
234	R:R:D170	R:R:K169	5.53	No	No	0	1	3
235	R:R:K169	R:R:Q172	8.14	No	Yes	0	3	3
236	R:R:D170	R:R:N171	12.12	No	No	0	1	5
237	R:R:N171	R:R:Q172	6.6	No	Yes	0	5	3
238	R:R:D176	R:R:M174	5.54	No	No	0	4	4
239	R:R:T175	R:R:Y177	11.24	No	No	0	5	5
240	R:R:D176	R:R:Y179	5.75	No	No	0	4	1
241	R:R:P185	R:R:Y177	20.86	No	No	0	3	5
242	R:R:L180	R:R:Y179	3.52	No	No	0	3	1
243	R:R:E181	R:R:Y184	3.37	No	Yes	0	1	4
244	R:R:P185	R:R:Y184	4.17	No	Yes	0	3	4
245	R:R:I186	R:R:L255	5.71	No	No	0	3	4
246	R:R:I186	R:R:L256	4.28	No	No	0	3	2
247	R:R:L248	R:R:N189	2.75	Yes	No	1	5	5
248	R:R:D251	R:R:N189	2.69	Yes	No	1	5	5
249	R:R:L192	R:R:Y244	4.69	No	Yes	1	5	6
250	R:R:L192	R:R:L248	2.77	No	Yes	1	5	5
251	R:R:H245	R:R:M193	3.94	Yes	No	0	8	5
252	R:R:M193	R:R:T252	3.01	No	No	0	5	6
253	R:R:I199	R:R:L194	7.14	No	No	0	5	4
254	R:R:A196	R:R:H245	2.93	No	Yes	0	6	8
255	R:R:F197	R:R:L201	3.65	No	No	0	9	6
256	R:R:F197	R:R:L242	3.65	No	No	0	9	5
257	R:R:F197	R:R:H245	19.23	No	Yes	0	9	8
258	R:R:I199	R:R:S202	3.1	No	No	0	5	3
259	R:R:I204	R:R:L201	2.85	No	No	12	7	6
260	R:R:F237	R:R:L201	7.31	No	No	12	9	6
261	R:R:F237	R:R:I204	6.28	No	No	12	9	7
262	R:R:R210	R:R:Y206	11.32	No	No	4	3	3
263	R:R:I211	R:R:Y208	3.63	Yes	Yes	2	8	8
264	R:R:L230	R:R:Y208	12.89	No	Yes	2	7	8
265	R:R:V233	R:R:Y208	3.79	No	Yes	2	7	8
266	R:R:Y208	R:R:Y291	4.96	Yes	Yes	2	8	9
267	R:R:R213	R:R:Y209	6.17	No	No	0	4	3
268	R:R:I211	R:R:L230	4.28	Yes	No	2	8	7
269	R:R:S212	R:R:V227	3.23	No	No	0	4	5
270	R:R:I226	R:R:V215	4.61	No	No	0	7	8
271	R:R:H222	R:R:R221	12.41	No	No	0	5	4
272	R:R:H222	R:R:R225	6.77	No	No	0	5	7
273	R:R:R225	R:R:R228	4.26	No	No	0	7	6
274	R:R:V229	R:R:V294	4.81	No	No	0	7	6
275	R:R:I231	R:R:L235	2.85	No	No	0	4	5
276	R:R:L290	R:R:V233	4.47	No	No	2	7	7
277	R:R:V233	R:R:Y291	8.83	No	Yes	2	7	9
278	R:R:I238	R:R:V234	3.07	No	No	0	5	8
279	R:R:I239	R:R:L235	2.85	No	No	0	5	5
280	R:R:H283	R:R:V236	2.77	No	No	0	9	6
281	R:R:L286	R:R:V236	2.98	No	No	2	7	6
282	R:R:L290	R:R:V236	5.96	No	No	2	7	6
283	R:R:F237	R:R:W241	6.01	No	Yes	0	9	8
284	R:R:I238	R:R:L242	2.85	No	No	0	5	5
285	R:R:F240	R:R:I239	3.77	Yes	No	0	7	5
286	R:R:C282	R:R:F240	4.19	No	Yes	0	6	7
287	R:R:F240	R:R:H283	5.66	Yes	No	0	7	9
288	R:R:H245	R:R:W241	6.35	Yes	Yes	0	8	8
289	R:R:A280	R:R:W241	5.19	No	Yes	0	8	8
290	R:R:H283	R:R:W241	17.98	No	Yes	0	9	8
291	R:R:L242	R:R:L246	2.77	No	No	0	5	6
292	R:R:P243	R:R:T276	5.25	No	No	0	9	6
293	R:R:H245	R:R:Y244	7.62	Yes	Yes	0	8	6
294	R:R:L248	R:R:Y244	8.21	Yes	Yes	1	5	6
295	R:R:T276	R:R:Y244	4.99	No	Yes	0	6	6
296	R:R:E277	R:R:Y244	15.71	Yes	Yes	1	6	6
297	R:R:A280	R:R:Y244	4	No	Yes	0	8	6
298	R:R:L273	R:R:T247	4.42	No	No	0	5	5
299	R:R:T247	R:R:T276	6.28	No	No	0	5	6
300	R:R:L248	R:R:L273	2.77	Yes	No	1	5	5
301	R:R:D251	R:R:K254	4.15	Yes	No	1	5	3
302	R:R:D251	R:R:L255	2.71	Yes	No	1	5	4
303	R:R:D251	R:R:L269	2.71	Yes	No	0	5	5
304	R:R:L253	R:R:W258	5.69	No	No	0	4	2
305	R:R:K254	R:R:L255	4.23	No	No	1	3	4
306	R:R:F265	R:R:K254	3.72	No	No	0	1	3
307	R:R:L256	R:R:W258	13.67	No	No	0	2	2
308	R:R:F265	R:R:S261	5.28	No	No	0	1	3
309	R:R:C263	R:R:E266	3.04	No	No	0	6	3
310	R:R:E264	R:R:R267	8.14	No	No	0	4	3
311	R:R:F265	R:R:L269	3.65	No	No	0	1	5
312	R:R:R267	R:R:S268	5.27	No	No	0	3	3
313	R:R:E277	R:R:F281	5.83	Yes	Yes	1	6	7
314	R:R:L286	R:R:L290	4.15	No	No	2	7	7
315	R:R:N287	R:R:P288	4.89	Yes	No	0	9	9
316	R:R:F293	R:R:V292	3.93	Yes	Yes	3	7	7
317	R:R:F298	R:R:V292	9.18	Yes	Yes	3	8	7
318	R:R:R299	R:R:T296	5.17	No	No	0	8	5
319	R:R:Q300	R:R:T296	5.67	No	No	0	5	5
320	L:L:A61	L:L:Y27	2.67	No	Yes	0	0	0
321	R:R:A132	R:R:Y138	2.67	No	No	0	7	4
322	R:R:D176	R:R:D178	2.66	No	No	0	4	6
323	R:R:E124	R:R:L127	2.65	Yes	No	0	6	6
324	R:R:F44	R:R:V83	2.62	No	No	0	6	6
325	L:L:T11	R:R:F25	2.59	No	No	0	0	3
326	R:R:A78	R:R:W152	2.59	No	Yes	0	8	9
327	R:R:H96	R:R:L94	2.57	No	No	0	5	5
328	L:L:Q31	R:R:Q172	2.56	No	Yes	0	0	3
329	R:R:F46	R:R:I49	2.51	No	No	0	5	4
330	R:R:F154	R:R:I157	2.51	No	No	0	4	3
331	L:L:E42	L:L:H46	2.46	No	No	0	0	0
332	R:R:V113	R:R:W152	2.45	No	Yes	0	5	9
333	R:R:F240	R:R:L279	2.44	Yes	No	0	7	7
334	R:R:F293	R:R:L302	2.44	Yes	No	0	7	6
335	L:L:F49	R:R:D17	2.39	Yes	No	0	0	5
336	R:R:M136	R:R:Y138	2.39	No	No	0	4	4
337	L:L:L65	L:L:Y27	2.34	No	Yes	0	0	0
338	L:L:K18	L:L:W57	2.32	No	Yes	0	0	0
339	R:R:C285	R:R:G47	1.96	No	No	0	7	8
340	R:R:G224	R:R:V227	1.84	No	No	0	6	5
341	R:R:G295	R:R:V294	1.84	No	No	0	8	6
342	R:R:C282	R:R:C285	1.82	No	No	0	6	7
343	R:R:A117	R:R:A155	1.79	No	No	0	7	7
344	R:R:G195	R:R:I158	1.76	No	Yes	0	3	5
345	L:L:T11	R:R:P22	1.75	No	Yes	0	0	3
346	L:L:G35	R:R:M174	1.75	No	No	0	0	4
347	R:R:G41	R:R:M90	1.75	No	No	0	5	7
348	R:R:G224	R:R:K223	1.74	No	No	0	6	7
349	R:R:C263	R:R:S262	1.72	No	No	0	6	6
350	R:R:C173	R:R:V166	1.71	No	No	0	9	5
351	R:R:G195	R:R:L194	1.71	No	No	0	3	4
352	R:R:A76	R:R:V54	1.7	No	Yes	0	8	9
353	R:R:C110	R:R:T85	1.69	No	Yes	0	4	7
354	R:R:K33	R:R:P34	1.67	No	No	0	4	3
355	R:R:S218	R:R:S220	1.63	No	No	0	5	4
356	R:R:A76	R:R:I55	1.62	No	No	0	8	7
357	R:R:V42	R:R:V43	1.6	No	No	0	5	7
358	R:R:V141	R:R:V70	1.6	No	Yes	0	4	6
359	R:R:V113	R:R:V156	1.6	No	No	0	5	3
360	R:R:V215	R:R:V227	1.6	No	No	0	8	5
361	R:R:T252	R:R:V190	1.59	No	No	0	6	4
362	L:L:A51	L:L:L41	1.58	No	No	0	0	0
363	R:R:A114	R:R:L81	1.58	No	No	0	8	6
364	R:R:A307	R:R:L306	1.58	No	No	0	3	6
365	R:R:I211	R:R:S212	1.55	Yes	No	0	8	4
366	R:R:A132	R:R:D128	1.54	No	Yes	0	7	8
367	L:L:K14	L:L:S13	1.53	Yes	No	0	0	0
368	R:R:K223	R:R:S220	1.53	No	No	0	7	4
369	R:R:K257	R:R:S260	1.53	No	No	0	3	3
370	R:R:F298	R:R:G295	1.51	Yes	No	0	8	8
371	R:R:K297	R:R:T296	1.5	No	No	0	7	5
372	R:R:L39	R:R:V35	1.49	No	No	0	5	5
373	R:R:L180	R:R:V165	1.49	No	No	0	3	5
374	R:R:L194	R:R:V198	1.49	No	No	0	4	5
375	R:R:L269	R:R:V250	1.49	No	No	0	5	5
376	R:R:L106	R:R:T105	1.47	No	No	0	4	8
377	R:R:I149	R:R:I153	1.47	No	No	0	4	3
378	R:R:I153	R:R:I157	1.47	No	No	0	3	3
379	R:R:A100	R:R:H96	1.46	No	No	0	8	5
380	R:R:E181	R:R:S183	1.44	No	No	0	1	1
381	R:R:A114	R:R:F82	1.39	No	Yes	0	8	7
382	L:L:D60	L:L:K59	1.38	No	No	0	0	0
383	R:R:L302	R:R:L53	1.38	No	No	0	6	6
384	L:L:K14	R:R:E18	1.35	Yes	Yes	5	0	3
385	R:R:R267	R:R:V28	1.31	No	No	0	3	4
386	R:R:R271	R:R:V28	1.31	No	No	0	2	4
387	R:R:F249	R:R:V250	1.31	No	No	0	5	5
388	R:R:F56	R:R:I55	1.26	No	No	0	3	7
389	R:R:F298	R:R:K297	1.24	Yes	No	0	8	7
390	R:R:F293	R:R:L289	1.22	Yes	No	0	7	6
391	L:L:Q68	L:L:R67	1.17	No	No	0	0	0
392	R:R:I259	R:R:W258	1.17	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H2	6.69	7	1	0
2	L:L:N9	4.025	4	8	0
3	L:L:I10	4.8475	4	6	0
4	L:L:K14	2.6175	4	5	0
5	L:L:I19	4.8525	4	5	0
6	L:L:Y27	4.67	4	0	0
7	L:L:I40	3.8925	4	6	0
8	L:L:T43	3.5075	4	9	0
9	L:L:F49	4.0325	4	5	0
10	L:L:W57	8.1175	4	0	0
11	R:R:E18	5.20833	6	5	3
12	R:R:P22	3.9625	4	6	3
13	R:R:Y40	5.748	5	0	7
14	R:R:N51	4.0675	4	0	9
15	R:R:V54	3.35	4	3	9
16	R:R:I58	6.0425	4	3	6
17	R:R:R62	5.5375	4	3	5
18	R:R:D69	6.4375	4	3	8
19	R:R:V70	3.295	4	0	6
20	R:R:Y71	8.9825	4	0	7
21	R:R:D79	4.746	5	2	9
22	R:R:F82	7.1025	4	1	7
23	R:R:T85	4.4925	4	0	7
24	R:R:W89	6.945	6	1	7
25	R:R:L107	5.9375	4	0	5
26	R:R:F111	6.93167	6	1	7
27	R:R:Y112	7.42	4	1	5
28	R:R:F116	3.8825	4	1	7
29	R:R:F121	7.458	5	7	7
30	R:R:E124	9.8425	4	0	6
31	R:R:I125	5.5525	4	2	8
32	R:R:D128	6.23	4	0	8
33	R:R:Y130	7.32167	6	4	8
34	R:R:R139	7.47833	6	4	7
35	R:R:W151	8.492	5	0	6
36	R:R:W152	5.212	5	7	9
37	R:R:I158	4.9475	4	0	5
38	R:R:P161	3.8525	4	0	9
39	R:R:H162	8.686	5	1	4
40	R:R:Q172	6.13	4	0	3
41	R:R:Y184	3.5275	4	0	4
42	R:R:Y208	6.18	6	2	8
43	R:R:I211	4.94	4	2	8
44	R:R:F240	4.015	4	0	7
45	R:R:W241	7.79	5	0	8
46	R:R:Y244	7.53667	6	1	6
47	R:R:H245	8.014	5	0	8
48	R:R:L248	4.072	5	1	5
49	R:R:D251	3.065	4	1	5
50	R:R:E277	8.9725	4	1	6
51	R:R:F281	8.095	4	1	7
52	R:R:N287	5.685	4	2	9
53	R:R:Y291	7.062	5	2	9
54	R:R:V292	6.1175	4	3	7
55	R:R:F293	2.88	4	3	7
56	R:R:F298	4.458	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H2	R:R:Y40	10.0855	4.36	Yes	Yes	0	0	7
2	L:L:H2	R:R:F111	11.3824	10.18	Yes	Yes	1	0	7
3	R:R:F111	R:R:W89	65.9755	4.01	Yes	Yes	1	7	7
4	L:L:H2	R:R:E277	39.7696	11.08	Yes	Yes	1	0	6
5	R:R:E277	R:R:Y244	55.7711	15.71	Yes	Yes	1	6	6
6	R:R:L248	R:R:Y244	22.3003	8.21	Yes	Yes	1	5	6
7	R:R:L248	R:R:N189	25.0873	2.75	Yes	No	1	5	5
8	R:R:W89	R:R:Y92	100	3.86	Yes	No	0	7	6
9	L:L:K7	R:R:Y92	99.1862	3.58	No	No	0	0	6
10	L:L:K7	L:L:S33	98.3649	4.59	No	No	0	0	0
11	L:L:S33	R:R:Q172	97.5362	7.22	No	Yes	0	0	3
12	L:L:Q31	R:R:Q172	83.2664	2.56	No	Yes	0	0	3
13	L:L:N9	L:L:Q31	82.3114	6.6	Yes	No	0	0	0
14	L:L:N9	R:R:F25	79.4017	3.62	Yes	No	0	0	3
15	L:L:T11	R:R:F25	78.4169	2.59	No	No	0	0	3
16	L:L:T11	R:R:P22	73.3816	1.75	No	Yes	0	0	3
17	L:L:I40	R:R:P22	44.0059	5.08	Yes	Yes	6	0	3
18	L:L:I10	L:L:I40	11.4641	2.94	Yes	Yes	6	0	0
19	R:R:P22	R:R:T21	31.6462	5.25	Yes	No	0	3	3
20	L:L:F49	R:R:T21	30.3493	5.19	Yes	No	0	0	3
21	L:L:F49	R:R:E18	26.3434	4.66	Yes	Yes	5	0	3
22	L:L:I40	L:L:L48	32.9952	4.28	Yes	No	0	0	0
23	L:L:H46	L:L:L48	31.7057	3.86	No	No	0	0	0
24	L:L:E42	L:L:H46	30.4088	2.46	No	No	0	0	0
25	L:L:E42	L:L:H26	29.1044	8.62	No	No	0	0	0
26	L:L:H26	L:L:L65	27.7926	6.43	No	No	0	0	0
27	L:L:L65	L:L:Y27	26.4734	2.34	No	Yes	0	0	0
28	L:L:I39	L:L:Y27	21.1185	4.84	No	Yes	0	0	0
29	L:L:I39	L:L:P53	19.7659	5.08	No	No	0	0	0
30	L:L:D52	L:L:P53	18.4021	11.27	No	No	0	0	0
31	L:L:I19	R:R:E18	15.5072	5.47	Yes	Yes	5	0	3
32	L:L:I19	L:L:L24	12.8131	5.71	Yes	No	0	0	0
33	L:L:D52	L:L:K54	15.6522	6.91	No	No	0	0	0
34	L:L:E55	L:L:K54	14.2661	14.85	No	No	0	0	0
35	L:L:E55	L:L:W57	12.8725	17.45	No	Yes	0	0	0
36	R:R:F111	R:R:Y112	52.2854	3.09	Yes	Yes	1	7	5
37	R:R:H162	R:R:Y112	15.3177	18.51	Yes	Yes	1	4	5
38	R:R:H162	R:R:P161	22.9803	6.1	Yes	Yes	0	4	9
39	R:R:P161	R:R:Y184	24.5782	2.78	Yes	Yes	0	9	4
40	R:R:V165	R:R:Y184	16.5292	3.79	No	Yes	0	5	4
41	R:R:L180	R:R:V165	13.3148	1.49	No	No	0	3	5
42	R:R:L180	R:R:Y179	11.676	3.52	No	No	0	3	1
43	R:R:D176	R:R:Y179	10.0297	5.75	No	No	0	4	1
44	R:R:N171	R:R:Q172	18.3501	6.6	No	Yes	0	5	3
45	R:R:N171	R:R:N97	15.6522	4.09	No	No	0	5	9
46	R:R:N97	R:R:S98	14.2661	4.47	No	No	0	9	3
47	R:R:L99	R:R:S98	12.8725	3	No	No	0	7	3
48	R:R:H96	R:R:L99	11.4716	3.86	No	No	0	5	7
49	R:R:F281	R:R:Y40	10.9959	6.19	Yes	Yes	0	7	7
50	R:R:E277	R:R:F281	13.0137	5.83	Yes	Yes	1	6	7
51	R:R:H245	R:R:Y244	39.3831	7.62	Yes	Yes	0	8	6
52	R:R:H245	R:R:W241	26.087	6.35	Yes	Yes	0	8	8
53	R:R:H283	R:R:W241	33.311	17.98	No	Yes	0	9	8
54	R:R:F240	R:R:H283	31.3787	5.66	Yes	No	0	7	9
55	R:R:C282	R:R:F240	21.1037	4.19	No	Yes	0	6	7
56	R:R:C282	R:R:C285	19.0264	1.82	No	No	0	6	7
57	R:R:C285	R:R:G47	10.6429	1.96	No	No	0	7	8
58	R:R:A280	R:R:Y244	23.9651	4	No	Yes	0	8	6
59	R:R:A280	R:R:W241	23.4931	5.19	No	Yes	0	8	8
60	R:R:F111	R:R:F82	41.6648	7.5	Yes	Yes	1	7	7
61	R:R:C284	R:R:F82	52.4229	5.59	No	Yes	0	8	7
62	R:R:C284	R:R:D79	52.0513	3.11	No	Yes	0	8	9
63	R:R:D79	R:R:N51	29.7213	4.04	Yes	Yes	0	9	9
64	R:R:N51	R:R:V54	27.6663	2.96	Yes	Yes	0	9	9
65	R:R:D79	R:R:N287	12.5009	6.73	Yes	Yes	2	9	9
66	R:R:V292	R:R:V54	19.0896	4.81	Yes	Yes	3	7	9
67	R:R:F293	R:R:L302	10.3716	2.44	Yes	No	0	7	6
68	R:R:F298	R:R:V292	24.3515	9.18	Yes	Yes	3	8	7
69	R:R:F116	R:R:Y112	36.7633	3.09	Yes	Yes	1	7	5
70	R:R:F116	R:R:I158	46.3545	6.28	Yes	Yes	0	7	5
71	R:R:F154	R:R:I158	50.7618	6.28	No	Yes	0	4	5
72	R:R:F154	R:R:W151	48.8443	7.02	No	Yes	0	4	6
73	R:R:E124	R:R:W151	45.1877	15.27	Yes	Yes	0	6	6
74	R:R:E124	R:R:Y71	31.0479	17.96	Yes	Yes	0	6	7
75	R:R:D128	R:R:Y71	18.3575	10.34	Yes	Yes	0	8	7
76	R:R:D128	R:R:S67	11.832	5.89	Yes	No	0	8	6
77	R:R:E124	R:R:R139	26.1018	3.49	Yes	Yes	0	6	7
78	R:R:D128	R:R:R139	15.4552	7.15	Yes	Yes	0	8	7
79	R:R:D79	R:R:L75	11.6945	5.43	Yes	No	2	9	9
80	R:R:I122	R:R:L75	11.1966	2.85	No	No	2	8	9
81	R:R:I122	R:R:Y291	22.0476	7.25	No	Yes	2	8	9
82	R:R:I125	R:R:Y291	26.1761	6.04	Yes	Yes	2	8	9
83	R:R:I122	R:R:N287	11.9361	4.25	No	Yes	2	8	9
84	R:R:F72	R:R:V292	18.2572	6.55	No	Yes	0	8	7
85	R:R:F121	R:R:W151	12.4712	7.02	Yes	Yes	0	7	6
86	R:R:F111	R:R:T85	10.0818	10.38	Yes	Yes	0	7	7
87	R:R:F197	R:R:H245	11.8135	19.23	No	Yes	0	9	8
88	R:R:F197	R:R:L201	10.55	3.65	No	No	0	9	6
89	R:R:I204	R:R:L201	10.5574	2.85	No	No	12	7	6
90	R:R:A126	R:R:I204	23.5043	3.25	No	No	0	9	7
91	R:R:F237	R:R:W241	15.3995	6.01	No	Yes	0	9	8
92	R:R:F237	R:R:I204	14.4593	6.28	No	No	12	9	7
93	R:R:Y208	R:R:Y291	25.2471	4.96	Yes	Yes	2	8	9
94	R:R:A126	R:R:Y208	22.1739	6.67	No	Yes	0	9	8
95	R:R:R139	R:R:Y131	18.874	11.32	Yes	No	4	7	5
96	R:R:Y130	R:R:Y131	11.3452	2.98	Yes	No	4	8	5
97	R:R:I211	R:R:Y208	28.3501	3.63	Yes	Yes	2	8	8
98	R:R:L192	R:R:Y244	16.6035	4.69	No	Yes	1	5	6
99	R:R:D251	R:R:N189	23.7421	2.69	Yes	No	1	5	5
100	R:R:V233	R:R:Y291	12.0438	8.83	No	Yes	2	7	9
101	R:R:H283	R:R:V236	15.236	2.77	No	No	0	9	6
102	R:R:L290	R:R:V236	12.4786	5.96	No	No	2	7	6
103	R:R:L290	R:R:V233	12.0141	4.47	No	No	2	7	7
104	R:R:I211	R:R:S212	22.7685	1.55	Yes	No	0	8	4
105	R:R:S212	R:R:V227	19.948	3.23	No	No	0	4	5
106	R:R:G224	R:R:V227	11.4418	1.84	No	No	0	6	5
107	L:L:H2	R:R:W89	37.5845	4.23	Yes	Yes	1	0	7
108	R:R:H162	R:R:L192	23.9688	5.14	Yes	No	1	4	5
109	R:R:F281	R:R:F82	12.9506	13.93	Yes	Yes	1	7	7
110	R:R:R129	R:R:Y208	12.3411	5.14	No	Yes	2	9	8
111	R:R:I125	R:R:Y71	33.3854	3.63	Yes	Yes	0	8	7
112	R:R:F116	R:R:H162	12.0847	3.39	Yes	Yes	1	7	4
113	R:R:I125	R:R:R129	12.2891	6.26	Yes	No	2	8	9
114	R:R:F72	R:R:I125	18.9521	6.28	No	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W89	6.09	1	No	Yes	0	7	0	1
L:L:?1	R:R:V166	3.19	1	No	No	0	5	0	1
L:L:H2	R:R:Y40	4.36	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:W89	4.23	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:F111	10.18	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:E277	11.08	1	Yes	Yes	0	6	0	1
L:L:H3	R:R:N189	5.1	1	No	No	0	5	0	1
L:L:H3	R:R:L248	3.86	1	No	Yes	0	5	0	1
L:L:H3	R:R:L273	11.57	1	No	No	0	5	0	1
L:L:G4	R:R:I274	5.29	1	No	No	0	5	0	1
L:L:G4	R:R:E277	3.27	1	No	Yes	0	6	0	1
L:L:V5	R:R:W89	9.81	1	No	Yes	0	7	0	1
L:L:T6	R:R:L29	2.95	0	No	No	0	3	0	1
L:L:T6	R:R:K270	9.01	0	No	No	0	4	0	1
L:L:K7	R:R:Y92	3.58	0	No	No	0	6	0	1
L:L:N9	R:R:V24	2.96	8	Yes	No	0	2	0	1
L:L:N9	R:R:F25	3.62	8	Yes	No	0	3	0	1
L:L:N9	R:R:T26	2.92	8	Yes	No	0	4	0	1
L:L:T11	R:R:C23	6.76	0	No	No	0	8	0	1
L:L:K14	R:R:D19	2.77	5	Yes	No	0	4	0	1
L:L:K14	R:R:A20	4.82	5	Yes	No	0	4	0	1
L:L:T16	R:R:E18	11.29	5	No	Yes	0	3	0	1
L:L:S17	R:R:E18	2.87	0	No	Yes	0	3	0	1
L:L:I19	R:R:Y16	4.84	5	Yes	No	0	5	0	1
L:L:I19	R:R:E18	5.47	5	Yes	Yes	0	3	0	1
L:L:S33	R:R:Q172	7.22	0	No	Yes	0	3	0	1
L:L:K36	R:R:D178	6.91	0	No	No	0	6	0	1
L:L:I40	R:R:P22	5.08	6	Yes	Yes	0	3	0	1
L:L:F49	R:R:E18	4.66	5	Yes	Yes	0	3	0	1
L:L:F49	R:R:T21	5.19	5	Yes	No	0	3	0	1
L:L:C50	R:R:P22	3.77	6	No	Yes	0	3	0	1
R:R:D15	R:R:Y16	9.2	0	No	No	4	5	2	1
R:R:E18	R:R:Y16	5.61	5	Yes	No	3	5	1	1
R:R:A20	R:R:D19	3.09	5	No	No	4	4	1	1
R:R:P22	R:R:T21	5.25	6	Yes	No	3	3	1	1
R:R:C23	R:R:C263	7.28	0	No	No	8	6	1	2
R:R:T26	R:R:V24	6.35	8	No	No	4	2	1	1
R:R:L29	R:R:S32	3	0	No	No	3	3	1	2
R:R:I274	R:R:S32	4.64	0	No	No	5	3	1	2
R:R:T36	R:R:Y40	8.74	0	No	Yes	5	7	2	1
R:R:I274	R:R:T36	4.56	0	No	No	5	5	1	2
R:R:L86	R:R:Y40	5.86	0	No	Yes	8	7	2	1
R:R:M90	R:R:Y40	3.59	0	No	Yes	7	7	2	1
R:R:F281	R:R:Y40	6.19	1	Yes	Yes	7	7	2	1
R:R:F111	R:R:F82	7.5	1	Yes	Yes	7	7	1	2
R:R:F281	R:R:F82	13.93	1	Yes	Yes	7	7	2	2
R:R:L86	R:R:T85	2.95	0	No	Yes	8	7	2	2
R:R:L107	R:R:T85	2.95	0	Yes	Yes	5	7	2	2
R:R:F111	R:R:T85	10.38	1	Yes	Yes	7	7	1	2
R:R:W89	R:R:Y92	3.86	1	Yes	No	7	6	1	1
R:R:L107	R:R:W89	13.67	0	Yes	Yes	5	7	2	1
R:R:F111	R:R:W89	4.01	1	Yes	Yes	7	7	1	1
R:R:F111	R:R:Y112	3.09	1	Yes	Yes	7	5	1	2
R:R:F111	R:R:F281	6.43	1	Yes	Yes	7	7	1	2
R:R:M174	R:R:T167	3.01	0	No	No	4	4	1	2
R:R:K169	R:R:Q172	8.14	0	No	Yes	3	3	2	1
R:R:N171	R:R:Q172	6.6	0	No	Yes	5	3	2	1
R:R:D176	R:R:M174	5.54	0	No	No	4	4	2	1
R:R:L248	R:R:N189	2.75	1	Yes	No	5	5	1	1
R:R:D251	R:R:N189	2.69	1	Yes	No	5	5	2	1
R:R:L192	R:R:Y244	4.69	1	No	Yes	5	6	2	2
R:R:L192	R:R:L248	2.77	1	No	Yes	5	5	2	1
R:R:L248	R:R:Y244	8.21	1	Yes	Yes	5	6	1	2
R:R:E277	R:R:Y244	15.71	1	Yes	Yes	6	6	1	2
R:R:L273	R:R:T247	4.42	1	No	No	5	5	1	2
R:R:L248	R:R:L273	2.77	1	Yes	No	5	5	1	1
R:R:E277	R:R:F281	5.83	1	Yes	Yes	6	7	1	2
R:R:D176	R:R:D178	2.66	0	No	No	4	6	2	1
L:L:T11	R:R:F25	2.59	0	No	No	0	3	0	1
L:L:Q31	R:R:Q172	2.56	0	No	Yes	0	3	0	1
L:L:F49	R:R:D17	2.39	5	Yes	No	0	5	0	1
L:L:T11	R:R:P22	1.75	0	No	Yes	0	3	0	1
L:L:G35	R:R:M174	1.75	0	No	No	0	4	0	1
R:R:C173	R:R:V166	1.71	10	No	No	9	5	2	1
L:L:K14	R:R:E18	1.35	5	Yes	Yes	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RKN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	338
Number of Links	392
Number of Hubs	56
Number of Links mediated by Hubs	200
Number of Communities	12
Number of Nodes involved in Communities	87
Number of Links involved in Communities	116

Path Summary
Number Of Nodes in MetaPath	115
Number Of Links MetaPath	114
Number of Shortest Paths	78578
Length Of Smallest Path	3
Average Path Length	14.8978
Length of Longest Path	44
Minimum Path Strength	1.31
Average Path Strength	5.61136
Maximum Path Strength	16.615
Minimum Path Correlation	0.7
Average Path Correlation	0.950385
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	60.7483
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.176
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • CX3C chemokine receptor binding • signaling receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • CCR chemokine receptor binding • molecular function activator activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • CXCR1 chemokine receptor binding • interleukin-8 receptor binding • CXCR chemokine receptor binding • cell adhesion molecule binding • integrin binding • chemoattractant activity • cell surface receptor signaling pathway • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • regulation of multicellular organismal development • regulation of developmental process • cellular developmental process • cell development • regulation of neurogenesis • regulation of cell differentiation • nervous system development • regulation of cell development • regulation of nervous system development • neurogenesis • cell differentiation • regulation of multicellular organismal process • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • positive regulation of locomotion • regulation of cell motility • regulation of microglial cell migration • glial cell migration • macrophage migration • regulation of glial cell migration • positive regulation of cell migration • regulation of macrophage migration • gliogenesis • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • positive regulation of microglial cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • cell motility • positive regulation of immune system process • locomotion • positive regulation of cellular process • positive regulation of macrophage migration • regulation of leukocyte migration • microglial cell migration • positive regulation of leukocyte migration • leukocyte migration • positive regulation of glial cell migration • immune system process • regulation of locomotion • mononuclear cell migration • cellular component organization • cellular component biogenesis • cellular component assembly • protein-containing complex organization • protein-containing complex assembly • integrin activation • cellular component organization or biogenesis • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • developmental maturation • generation of neurons • neuron differentiation • neuron remodeling • anatomical structure maturation • neuron development • neuron maturation • cell maturation • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • response to ischemia • cell chemotaxis • chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • taxis • granulocyte chemotaxis • leukocyte chemotaxis • positive chemotaxis • leukocyte migration involved in inflammatory response • autocrine signaling • regulation of neuron projection development • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • neuron projection development • positive regulation of neuron projection development • positive regulation of cell projection organization • plasma membrane bounded cell projection organization • regulation of cell projection organization • regulation of plasma membrane bounded cell projection organization • signal transduction in absence of ligand • cell death • extrinsic apoptotic signaling pathway • apoptotic signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • apoptotic process • programmed cell death • negative regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • eosinophil chemotaxis • eosinophil migration • lymphocyte chemotaxis • lymphocyte migration • wound healing • blood vessel morphogenesis • tube development • angiogenesis involved in wound healing • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • response to wounding • blood vessel development • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • cell activation • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • glial cell activation • neuroinflammatory response • cellular homeostasis • neuron cellular homeostasis • homeostatic process • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • regulation of intracellular signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of signaling • regulation of programmed cell death • negative regulation of cell communication • negative regulation of signal transduction in absence of ligand • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • negative regulation of response to stimulus • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of signal transduction • regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of apoptotic signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • immune response • regulation of macrophage activation • negative regulation of inflammatory response • regulation of leukocyte activation • regulation of cell activation • regulation of neuroinflammatory response • negative regulation of microglial cell activation • negative regulation of cell activation • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of microglial cell activation • negative regulation of neuroinflammatory response • negative regulation of leukocyte activation • negative regulation of macrophage activation • regulation of transforming growth factor beta production • transforming growth factor beta1 production • regulation of transforming growth factor beta1 production • positive regulation of transforming growth factor beta1 production • transforming growth factor beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of transforming growth factor beta production • positive regulation of cytokine production • response to chemokine • cellular response to chemokine • chemokine-mediated signaling pathway • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of lipopolysaccharide-mediated signaling pathway • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • cellular response to lipopolysaccharide • response to biotic stimulus • lipopolysaccharide-mediated signaling pathway • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to other organism • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to molecule of bacterial origin • negative regulation of interleukin-1 alpha production • regulation of interleukin-1 alpha production • interleukin-1 alpha production • cellular component disassembly • cell junction organization • cell junction disassembly • synapse pruning • synapse organization • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • regulation of actin filament organization • actin cytoskeleton organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of cellular component biogenesis • regulation of organelle organization • organelle organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • leukocyte adhesive activation • cellular extravasation • regulation of vasculature development • positive regulation of developmental process • regulation of anatomical structure morphogenesis • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • humoral immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • regulation of calcium-independent cell-cell adhesion • positive regulation of cell-cell adhesion • calcium-independent cell-cell adhesion • cell-cell adhesion • regulation of cell-cell adhesion • positive regulation of calcium-independent cell-cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • macrophage chemotaxis • regulation of synaptic plasticity • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of biological quality • microglial cell proliferation • leukocyte proliferation • macrophage proliferation • glial cell proliferation • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of neuron migration • regulation of neuron migration • neuron migration • glutamate receptor signaling pathway • negative regulation of glutamate receptor signaling pathway • regulation of glutamate receptor signaling pathway • neuron apoptotic process • negative regulation of neuron apoptotic process • hippocampal neuron apoptotic process • regulation of hippocampal neuron apoptotic process • negative regulation of hippocampal neuron apoptotic process • regulation of neuron apoptotic process • neuroblast proliferation • positive regulation of nervous system development • regulation of neuroblast proliferation • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • neural precursor cell proliferation • perinuclear region of cytoplasm • somatodendritic compartment • cell body • neuronal cell body • cell surface • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • positive regulation of cytosolic calcium ion concentration • calcium-mediated signaling • symbiont-mediated perturbation of host cellular process • symbiont-mediated perturbation of host process • symbiont-mediated transformation of host cell • modulation of process of another organism • biological process involved in interaction with host • biological process involved in symbiotic interaction • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P69332
Sequence	>7RKN_nogp_Chain_R D Y D E D A T P C V F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R R R I Q C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D H N S L A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y M R Y R P V K Q A C L F S I F W W I F A V I I A I P H F M V V T K K D N Q C M T D Y D Y L E V S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S Q S R H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K W I S S S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K F R Q E L H C L L A E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKF	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP	chim(NtGi1-G11)/β1/γ2	4	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKF (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	GDP		4	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKM	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.5	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKM (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.5	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKN	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-	Gi1/β1/γ2	3.6	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKN (No Gprot)	A	Other	Unclassified	US28	Human betaherpesvirus 5	Fractalkine	-		3.6	2022-01-26	doi.org/10.1126/sciadv.abl5442
	4XT1	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	2.89	2015-03-04	doi.org/10.1126/science.aaa5026
	4XT3	A	Other	Unclassified	US28	Human cytomegalovirus (strain ad169)	Fractalkine	-	-	3.8	2015-03-04	doi.org/10.1126/science.aaa5026
	5WB1	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	-	-	-	3.51	2018-06-13	doi.org/10.7554/eLife.35850
	5WB2	A	Other	Unclassified	US28	Human cytomegalovirus (strain towne)	CX3CL1.35	-	-	3.5	2018-06-13	doi.org/10.7554/eLife.35850

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Download 7RKN_nogp.zip

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