psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C64	R:R:E140	4.56	No	Yes	0	7	5
2	R:R:C64	R:R:P175	5.65	No	No	0	7	5
3	R:R:C178	R:R:C64	7.28	No	No	0	6	7
4	R:R:G65	R:R:R138	7.51	No	No	0	4	4
5	R:R:L91	R:R:R66	7.29	Yes	No	0	5	6
6	R:R:R173	R:R:R66	4.26	No	No	0	4	6
7	R:R:A68	R:R:L91	4.73	No	Yes	0	5	5
8	R:R:C134	R:R:C70	7.28	No	No	9	9	9
9	R:R:E71	R:R:R74	4.65	No	No	0	7	4
10	R:R:L73	R:R:L83	5.54	No	No	0	7	7
11	R:R:G86	R:R:L73	3.42	No	No	0	6	7
12	R:R:Q99	R:R:R74	9.35	No	No	0	9	4
13	R:R:Q99	R:R:Y75	5.64	No	No	0	9	3
14	R:R:E100	R:R:Y75	3.37	No	No	0	4	3
15	R:R:H103	R:R:Y75	13.07	No	No	0	5	3
16	R:R:N76	R:R:V82	4.43	No	No	0	4	4
17	R:R:L83	R:R:N76	4.12	No	No	0	7	4
18	R:R:C127	R:R:C78	7.28	No	No	0	9	9
19	R:R:C78	R:R:I185	4.91	No	Yes	4	9	4
20	R:R:C78	R:R:F187	4.19	No	Yes	4	9	6
21	R:R:L106	R:R:L79	8.3	No	Yes	0	8	5
22	R:R:L79	R:R:V107	4.47	Yes	No	0	5	4
23	R:R:F187	R:R:S81	13.21	Yes	No	0	6	5
24	R:R:L83	R:R:M131	5.65	No	Yes	0	7	5
25	R:R:P84	R:R:Y85	6.95	No	No	0	4	9
26	R:R:N184	R:R:P84	8.15	No	No	4	3	4
27	R:R:I185	R:R:P84	3.39	Yes	No	4	4	4
28	R:R:M131	R:R:Y85	4.79	Yes	No	0	5	9
29	R:R:K133	R:R:Y85	13.14	No	No	0	6	9
30	R:R:M131	R:R:T88	9.03	Yes	No	0	5	9
31	R:R:P132	R:R:T88	3.5	No	No	0	9	9
32	R:R:L91	R:R:S89	4.5	Yes	No	0	5	8
33	R:R:L91	R:R:L92	5.54	Yes	Yes	7	5	8
34	R:R:L91	R:R:V139	7.45	Yes	No	7	5	7
35	R:R:L92	R:R:P132	6.57	Yes	No	7	8	9
36	R:R:L92	R:R:V139	5.96	Yes	No	7	8	7
37	R:R:L92	R:R:R173	7.29	Yes	No	0	8	4
38	R:R:F166	R:R:G94	4.52	Yes	No	0	6	5
39	R:R:D95	R:R:K105	9.68	No	Yes	0	5	4
40	R:R:D95	R:R:F166	10.75	No	Yes	0	5	6
41	R:R:E101	R:R:S96	8.62	No	Yes	0	5	6
42	R:R:A102	R:R:S96	3.42	No	Yes	0	7	6
43	R:R:H103	R:R:V107	6.92	No	No	0	5	4
44	R:R:K105	R:R:L108	5.64	Yes	No	0	4	5
45	R:R:K105	R:R:W109	10.44	Yes	Yes	2	4	7
46	R:R:K105	R:R:Y130	9.55	Yes	Yes	2	4	7
47	R:R:L106	R:R:L126	4.15	No	No	0	8	9
48	R:R:L126	R:R:W109	6.83	No	Yes	2	9	7
49	R:R:W109	R:R:Y130	8.68	Yes	Yes	2	7	7
50	R:R:V157	R:R:W109	7.36	No	Yes	2	6	7
51	R:R:W109	R:R:W163	6.56	Yes	Yes	2	7	8
52	R:R:L167	R:R:W109	4.56	No	Yes	2	7	7
53	R:R:C111	R:R:C496	7.28	No	No	0	5	4
54	R:R:L112	R:R:W119	7.97	No	Yes	0	8	9
55	R:R:R113	R:R:W119	11	No	Yes	0	5	9
56	R:R:Q192	R:R:R113	5.84	No	No	0	4	5
57	R:R:G191	R:R:P116	4.06	No	No	10	5	9
58	R:R:P116	R:R:R199	5.76	No	No	10	9	4
59	R:R:D201	R:R:R117	4.76	No	No	0	5	5
60	R:R:R117	R:R:W206	8	No	Yes	0	5	4
61	R:R:C118	R:R:C154	7.28	No	No	0	9	9
62	R:R:Q123	R:R:W119	36.14	No	Yes	0	8	9
63	R:R:A120	R:R:S190	3.42	No	No	0	4	6
64	R:R:I122	R:R:T150	4.56	No	Yes	0	7	7
65	R:R:C154	R:R:I122	4.91	No	No	0	9	7
66	R:R:F187	R:R:Q123	29.28	Yes	No	0	6	8
67	R:R:P124	R:R:V182	3.53	No	No	0	5	4
68	R:R:F187	R:R:P124	5.78	Yes	No	0	6	5
69	R:R:L126	R:R:Y130	3.52	No	Yes	2	9	7
70	R:R:A128	R:R:V182	3.39	No	No	0	8	4
71	R:R:V129	R:R:Y130	6.31	No	Yes	0	7	7
72	R:R:F166	R:R:Y130	8.25	Yes	Yes	0	6	7
73	R:R:P132	R:R:V139	3.53	No	No	7	9	7
74	R:R:E135	R:R:K133	5.4	No	No	0	6	6
75	R:R:E135	R:R:R138	11.63	No	No	8	6	4
76	R:R:E135	R:R:E140	7.61	No	Yes	8	6	5
77	R:R:E140	R:R:R138	5.82	Yes	No	8	5	4
78	R:R:L141	R:R:P175	4.93	No	No	0	7	5
79	R:R:F174	R:R:P142	10.11	No	No	0	8	8
80	R:R:S143	R:R:T145	4.8	No	No	0	8	6
81	R:R:N180	R:R:S143	7.45	No	No	0	5	8
82	R:R:Q148	R:R:R144	5.84	No	No	0	5	6
83	R:R:C169	R:R:R144	4.18	No	No	0	9	6
84	R:R:E176	R:R:R144	10.47	No	No	0	4	6
85	R:R:L146	R:R:N180	12.36	No	No	0	6	5
86	R:R:C147	R:R:R151	4.18	No	Yes	2	9	5
87	R:R:C147	R:R:C169	7.28	No	No	2	9	9
88	R:R:C147	R:R:F174	4.19	No	No	2	9	8
89	R:R:R151	R:R:T150	3.88	Yes	Yes	0	5	7
90	R:R:R151	R:R:W163	11	Yes	Yes	2	5	8
91	R:R:R151	R:R:R168	6.4	Yes	No	2	5	4
92	R:R:G152	R:R:P153	4.06	No	No	0	4	6
93	R:R:C154	R:R:P153	3.77	No	No	0	9	6
94	R:R:V157	R:R:W163	9.81	No	Yes	2	6	8
95	R:R:E158	R:R:W163	5.45	No	Yes	0	7	8
96	R:R:E160	R:R:R159	4.65	Yes	No	11	4	5
97	R:R:R159	R:R:R485	13.86	No	No	11	5	5
98	R:R:E160	R:R:R485	4.65	Yes	No	11	4	5
99	R:R:E160	R:R:L489	11.93	Yes	No	0	4	4
100	R:R:N493	R:R:R161	9.64	No	No	0	5	5
101	R:R:L167	R:R:W163	4.56	No	Yes	2	7	8
102	R:R:R168	R:R:W163	4	No	Yes	2	4	8
103	R:R:F166	R:R:P164	7.22	Yes	No	0	6	9
104	R:R:F166	R:R:L167	8.53	Yes	No	0	6	7
105	R:R:C169	R:R:F174	6.98	No	No	2	9	8
106	R:R:P171	R:R:T170	5.25	No	No	0	3	6
107	R:R:D172	R:R:T170	5.78	No	No	0	4	6
108	R:R:E181	R:R:T179	7.06	No	No	0	5	4
109	R:R:N180	R:R:Q183	3.96	No	No	0	5	5
110	R:R:I185	R:R:N184	5.66	Yes	No	4	4	3
111	R:R:F187	R:R:I185	3.77	Yes	Yes	4	6	4
112	R:R:N188	R:R:S189	4.47	No	No	0	8	5
113	R:R:G191	R:R:R199	7.51	No	No	10	5	4
114	R:R:C193	R:R:R199	4.18	No	No	0	9	4
115	R:R:C193	R:R:C213	7.28	No	No	0	9	9
116	R:R:E194	R:R:P196	7.86	No	No	0	6	7
117	R:R:E194	R:R:Q491	5.1	No	Yes	0	6	4
118	R:R:E194	R:R:T495	7.06	No	No	0	6	4
119	R:R:P196	R:R:V195	3.53	No	No	0	7	4
120	R:R:L197	R:R:Y207	3.52	No	Yes	0	9	7
121	R:R:C213	R:R:L197	9.52	No	No	0	9	9
122	R:R:T200	R:R:W206	6.06	No	Yes	0	6	4
123	R:R:G214	R:R:T200	3.64	No	No	0	8	6
124	R:R:D298	R:R:T200	5.78	Yes	No	0	7	6
125	R:R:N202	R:R:P203	6.52	Yes	No	0	5	4
126	R:R:K204	R:R:N202	9.79	No	Yes	0	3	5
127	R:R:N202	R:R:S205	7.45	Yes	No	12	5	7
128	R:R:N202	R:R:R296	6.03	Yes	Yes	12	5	6
129	R:R:P203	R:R:W206	4.05	No	Yes	0	4	4
130	R:R:G304	R:R:K204	5.23	No	No	0	5	3
131	R:R:R296	R:R:S205	7.91	Yes	No	12	6	7
132	R:R:G212	R:R:W206	7.04	No	Yes	0	7	4
133	R:R:D209	R:R:Y207	10.34	No	Yes	0	4	7
134	R:R:V210	R:R:Y207	5.05	No	Yes	0	5	7
135	R:R:F484	R:R:Y207	8.25	Yes	Yes	5	6	7
136	R:R:V488	R:R:Y207	5.05	No	Yes	5	6	7
137	R:R:D209	R:R:R485	25.01	No	No	0	4	5
138	R:R:I215	R:R:P220	6.77	No	No	5	5	8
139	R:R:I215	R:R:M301	4.37	No	No	0	5	4
140	R:R:F484	R:R:I215	3.77	Yes	No	5	6	5
141	R:R:P220	R:R:Q216	7.9	No	No	0	8	7
142	R:R:C217	R:R:V294	3.42	No	No	0	9	8
143	R:R:C217	R:R:C295	7.28	No	No	0	9	9
144	R:R:E224	R:R:Q218	10.19	No	No	1	4	5
145	R:R:H227	R:R:Q218	3.71	Yes	No	1	7	5
146	R:R:Q218	R:R:S385	7.22	No	No	1	5	7
147	R:R:F222	R:R:N219	3.62	Yes	No	0	6	7
148	R:R:D384	R:R:N219	8.08	Yes	No	0	8	7
149	R:R:F484	R:R:P220	8.67	Yes	No	5	6	8
150	R:R:F484	R:R:L221	3.65	Yes	No	0	6	6
151	R:R:L221	R:R:P513	6.57	No	No	0	6	8
152	R:R:E226	R:R:F222	7	No	Yes	0	8	6
153	R:R:F222	R:R:H227	3.39	Yes	Yes	1	6	7
154	R:R:F222	R:R:V386	9.18	Yes	No	1	6	5
155	R:R:F222	R:R:P513	8.67	Yes	No	0	6	8
156	R:R:E518	R:R:F222	4.66	Yes	Yes	1	7	6
157	R:R:F222	W:W:?1	4.86	Yes	Yes	1	6	0
158	R:R:R512	R:R:T223	3.88	No	No	0	6	5
159	R:R:E224	R:R:H227	4.92	No	Yes	1	4	7
160	R:R:E224	R:R:Q228	6.37	No	No	0	4	3
161	R:R:E226	R:R:L515	6.63	No	Yes	0	8	5
162	R:R:H227	R:R:H231	4.78	Yes	No	0	7	7
163	R:R:H227	R:R:S385	6.97	Yes	No	1	7	7
164	R:R:H227	R:R:V386	8.3	Yes	No	1	7	5
165	R:R:D229	R:R:L515	4.07	No	Yes	0	6	5
166	R:R:D229	R:R:K519	8.3	No	No	0	6	7
167	R:R:I234	R:R:M230	5.83	No	No	0	7	7
168	R:R:L515	R:R:M230	5.65	Yes	No	0	5	7
169	R:R:H231	R:R:R290	19.18	No	No	0	7	9
170	R:R:F237	R:R:Y233	18.57	No	Yes	0	4	6
171	R:R:K519	R:R:Y233	20.3	No	Yes	0	7	6
172	R:R:L522	R:R:Y233	4.69	No	Yes	0	7	6
173	R:R:I234	R:R:W281	3.52	No	Yes	0	7	7
174	R:R:F285	R:R:I234	3.77	Yes	No	0	8	7
175	R:R:A235	R:R:F285	5.55	No	Yes	0	5	8
176	R:R:F237	R:R:F526	5.36	No	Yes	0	4	9
177	R:R:G238	R:R:L282	5.13	No	No	0	7	7
178	R:R:S278	R:R:T241	6.4	No	No	0	8	7
179	R:R:F526	R:R:T241	7.78	Yes	No	0	9	7
180	R:R:I530	R:R:T241	4.56	Yes	No	0	7	7
181	R:R:G242	R:R:S278	3.71	No	No	0	4	8
182	R:R:C244	R:R:I530	4.91	No	Yes	0	6	7
183	R:R:F275	R:R:T245	9.08	No	No	0	5	8
184	R:R:F275	R:R:L246	4.87	No	No	0	5	6
185	R:R:F247	R:R:T251	7.78	No	No	0	8	9
186	R:R:F247	R:R:W537	6.01	No	No	0	8	8
187	R:R:N271	R:R:T248	11.7	No	No	14	9	8
188	R:R:S533	R:R:T248	7.99	No	No	14	9	8
189	R:R:T248	R:R:V536	7.93	No	No	0	8	8
190	R:R:F268	R:R:L249	3.65	Yes	No	0	8	6
191	R:R:F275	R:R:L249	3.65	No	No	0	5	6
192	R:R:F252	R:R:F268	13.93	No	Yes	0	9	8
193	R:R:N260	R:R:W256	6.78	No	No	0	7	7
194	R:R:F268	R:R:W256	6.01	Yes	No	0	8	7
195	R:R:R261	R:R:S259	3.95	No	No	0	7	8
196	R:R:A264	R:R:R261	8.3	No	No	0	9	7
197	R:R:I266	R:R:Y262	8.46	Yes	Yes	0	8	9
198	R:R:L353	R:R:Y262	3.52	No	Yes	0	8	9
199	R:R:T357	R:R:Y262	14.98	No	Yes	0	6	9
200	R:R:F360	R:R:Y262	6.19	Yes	Yes	0	9	9
201	R:R:H361	R:R:Y262	6.53	Yes	Yes	0	9	9
202	R:R:V265	R:R:Y269	6.31	No	Yes	0	8	8
203	R:R:I266	R:R:W331	7.05	Yes	Yes	0	8	9
204	R:R:I266	R:R:L335	5.71	Yes	No	0	8	8
205	R:R:L267	R:R:W535	9.11	No	Yes	0	8	9
206	R:R:F268	R:R:Y269	6.19	Yes	Yes	0	8	8
207	R:R:W331	R:R:Y269	21.22	Yes	Yes	6	9	8
208	R:R:H361	R:R:Y269	10.89	Yes	Yes	6	9	8
209	R:R:M532	R:R:V270	4.56	Yes	No	0	8	8
210	R:R:N271	R:R:S533	4.47	No	No	14	9	9
211	R:R:A327	R:R:C273	3.61	No	No	0	9	9
212	R:R:F274	R:R:G328	4.52	No	No	0	9	8
213	R:R:F274	R:R:T528	5.19	No	No	0	9	7
214	R:R:F274	R:R:G529	6.02	No	No	0	9	9
215	R:R:A324	R:R:V276	3.39	No	No	0	7	5
216	R:R:G280	R:R:I320	3.53	No	No	0	7	5
217	R:R:V321	R:R:W281	4.9	No	Yes	0	8	7
218	R:R:I389	R:R:W281	5.87	No	Yes	0	9	7
219	R:R:L522	R:R:W281	3.42	No	Yes	0	7	7
220	R:R:M525	R:R:W281	6.98	No	Yes	0	5	7
221	R:R:F526	R:R:W281	6.01	Yes	Yes	0	9	7
222	R:R:F285	R:R:Q284	12.88	Yes	No	13	8	9
223	R:R:Q284	R:R:R290	15.19	No	No	13	9	9
224	R:R:G388	R:R:Q284	4.93	No	No	0	9	9
225	R:R:F285	R:R:R290	5.34	Yes	No	13	8	9
226	R:R:D298	R:R:R296	8.34	Yes	Yes	0	7	6
227	R:R:E310	R:R:R296	10.47	No	Yes	0	8	6
228	R:R:D298	R:R:T300	5.78	Yes	No	0	7	7
229	R:R:E305	R:R:R302	12.79	No	No	0	7	6
230	R:R:R302	R:R:S313	6.59	No	No	0	6	7
231	R:R:D382	R:R:L303	4.07	No	No	0	9	3
232	R:R:C314	R:R:E305	6.08	No	No	0	9	7
233	R:R:P306	R:R:V315	3.53	No	No	0	5	7
234	R:R:L312	R:R:V315	4.47	No	No	0	7	7
235	R:R:C314	R:R:C390	7.28	No	No	0	9	9
236	R:R:I317	R:R:I389	4.42	No	No	0	7	9
237	R:R:F318	R:R:Y322	8.25	Yes	Yes	1	9	9
238	R:R:F318	R:R:I375	5.02	Yes	Yes	1	9	7
239	R:R:F318	R:R:V381	9.18	Yes	No	0	9	8
240	R:R:F318	R:R:V392	3.93	Yes	No	1	9	9
241	R:R:T372	R:R:V319	4.76	No	No	0	9	7
242	R:R:M326	R:R:Y322	4.79	Yes	Yes	1	8	9
243	R:R:L371	R:R:Y322	8.21	No	Yes	1	8	9
244	R:R:T372	R:R:Y322	3.75	No	Yes	0	9	9
245	R:R:I375	R:R:Y322	6.04	Yes	Yes	1	7	9
246	R:R:F391	R:R:Y322	6.19	No	Yes	1	8	9
247	R:R:W365	R:R:Y323	7.72	Yes	No	0	9	8
248	R:R:P368	R:R:Y323	5.56	No	No	0	9	8
249	R:R:F369	R:R:Y323	4.13	No	No	0	7	8
250	R:R:L325	R:R:M525	5.65	No	No	0	5	5
251	R:R:M326	R:R:P368	3.35	Yes	No	0	8	9
252	R:R:L371	R:R:M326	4.24	No	Yes	1	8	8
253	R:R:M326	R:R:P407	6.71	Yes	No	0	8	9
254	R:R:I408	R:R:V329	4.61	No	No	0	7	6
255	R:R:V329	R:R:V411	6.41	No	No	0	6	5
256	R:R:T364	R:R:V330	4.76	No	No	0	9	6
257	R:R:H361	R:R:W331	7.41	Yes	Yes	6	9	9
258	R:R:T364	R:R:W331	26.68	No	Yes	0	9	9
259	R:R:W331	R:R:W365	17.81	Yes	Yes	6	9	9
260	R:R:F332	R:R:T336	3.89	Yes	No	0	9	7
261	R:R:F332	R:R:F455	5.36	Yes	No	16	9	8
262	R:R:F332	R:R:M532	9.95	Yes	Yes	16	9	8
263	R:R:V333	R:R:V411	4.81	No	No	0	9	5
264	R:R:F360	R:R:V334	6.55	Yes	No	0	9	7
265	R:R:L335	R:R:W339	20.5	No	Yes	0	8	9
266	R:R:G415	R:R:T336	3.64	No	No	0	8	7
267	R:R:L419	R:R:T336	4.42	No	No	0	7	7
268	R:R:K356	R:R:Y337	3.58	No	No	15	8	7
269	R:R:F360	R:R:Y337	5.16	Yes	No	15	9	7
270	R:R:F418	R:R:Y337	14.44	No	No	0	8	7
271	R:R:F343	R:R:W339	6.01	No	Yes	3	9	9
272	R:R:L452	R:R:W339	4.56	Yes	Yes	3	8	9
273	R:R:W339	R:R:W535	9.37	Yes	Yes	0	9	9
274	R:R:H340	R:R:K344	5.24	Yes	No	0	7	6
275	R:R:F418	R:R:H340	4.53	No	Yes	0	8	7
276	R:R:H340	R:R:R421	5.64	Yes	No	0	7	7
277	R:R:P352	R:R:T341	6.99	Yes	No	0	7	6
278	R:R:F343	R:R:L426	8.53	No	Yes	3	9	9
279	R:R:F343	R:R:L452	3.65	No	Yes	3	9	8
280	R:R:I429	R:R:L346	4.28	No	No	0	7	6
281	R:R:F360	R:R:K356	9.93	Yes	No	15	9	8
282	R:R:H361	R:R:W365	7.41	Yes	Yes	6	9	9
283	R:R:I375	R:R:V392	4.61	Yes	No	1	7	9
284	R:R:F403	R:R:I375	8.79	No	Yes	0	8	7
285	R:R:Q380	R:R:V378	8.6	No	No	17	7	5
286	R:R:V378	R:R:Y399	3.79	No	Yes	17	5	5
287	R:R:Q380	R:R:Y399	24.8	No	Yes	17	7	5
288	R:R:D382	R:R:Y394	10.34	No	Yes	0	9	5
289	R:R:C390	R:R:G383	3.92	No	No	0	9	8
290	R:R:D384	R:R:V386	4.38	Yes	No	1	8	5
291	R:R:D384	R:R:S387	7.36	Yes	No	1	8	8
292	R:R:D384	R:R:Y394	10.34	Yes	Yes	1	8	5
293	R:R:D384	W:W:?1	9.47	Yes	Yes	1	8	0
294	R:R:S387	W:W:?1	8.98	No	Yes	1	8	0
295	R:R:F391	R:R:Y394	5.16	No	Yes	1	8	5
296	R:R:F391	W:W:?1	4.86	No	Yes	1	8	0
297	R:R:Y394	W:W:?1	18.7	Yes	Yes	1	5	0
298	R:R:N396	R:R:R398	16.87	No	No	0	7	1
299	R:R:N396	R:R:Y399	9.3	No	Yes	0	7	5
300	R:R:F474	R:R:Y397	7.22	Yes	No	0	6	3
301	R:R:F403	R:R:Y399	6.19	No	Yes	0	8	5
302	R:R:R400	W:W:?1	15.75	No	Yes	0	9	0
303	R:R:A401	R:R:F474	4.16	No	Yes	0	6	6
304	R:R:H470	R:R:V404	4.15	Yes	No	0	7	7
305	R:R:F467	R:R:L405	9.74	No	No	0	7	8
306	R:R:H470	R:R:L405	9	Yes	No	0	7	8
307	R:R:F471	R:R:L405	3.65	No	No	0	4	8
308	R:R:I408	W:W:?1	4.27	No	Yes	0	7	0
309	R:R:F460	R:R:L412	4.87	No	No	0	5	7
310	R:R:L412	R:R:V463	16.39	No	No	0	7	7
311	R:R:F418	R:R:Y417	6.19	No	No	0	8	5
312	R:R:R421	R:R:Y417	5.14	No	No	0	7	5
313	R:R:L419	R:R:L452	4.15	No	Yes	0	7	8
314	R:R:G422	R:R:T425	3.64	No	No	0	8	7
315	R:R:L426	R:R:M449	4.24	Yes	No	0	9	9
316	R:R:F427	R:R:M449	8.71	No	No	0	7	9
317	R:R:H433	R:R:P434	9.15	No	No	0	8	7
318	R:R:H433	R:R:L437	6.43	No	No	0	8	6
319	R:R:K440	R:R:K444	4.31	No	No	0	6	9
320	R:R:R451	R:R:W535	12	No	Yes	0	9	9
321	R:R:F455	R:R:M532	4.98	No	Yes	16	8	8
322	R:R:F455	R:R:W535	20.04	No	Yes	0	8	9
323	R:R:F462	R:R:L458	4.87	No	No	0	7	6
324	R:R:F462	R:R:T528	6.49	No	No	0	7	7
325	R:R:F467	R:R:V463	3.93	No	No	0	7	7
326	R:R:H470	R:R:T466	5.48	Yes	No	1	7	8
327	R:R:N521	R:R:T466	4.39	Yes	No	1	8	8
328	R:R:T466	W:W:?1	8.82	No	Yes	1	8	0
329	R:R:C469	R:R:N521	9.45	No	Yes	0	7	8
330	R:R:H470	R:R:N521	7.65	Yes	Yes	1	7	8
331	R:R:H470	W:W:?1	16.67	Yes	Yes	1	7	0
332	R:R:F471	R:R:F474	4.29	No	Yes	0	4	6
333	R:R:N476	R:R:Y472	13.96	No	No	0	6	7
334	R:R:S514	R:R:Y472	5.09	No	No	0	7	7
335	R:R:V517	R:R:Y472	8.83	No	No	0	6	7
336	R:R:N476	R:R:W480	12.43	No	Yes	0	6	9
337	R:R:Q477	R:R:W480	4.38	No	Yes	0	6	9
338	R:R:E481	R:R:Q477	6.37	No	No	0	5	6
339	R:R:N511	R:R:W480	3.39	Yes	Yes	0	4	9
340	R:R:P513	R:R:W480	28.38	No	Yes	0	8	9
341	R:R:D486	R:R:R482	10.72	No	No	0	4	3
342	R:R:N511	R:R:S483	5.96	Yes	No	0	4	7
343	R:R:F484	R:R:V488	6.55	Yes	No	5	6	6
344	R:R:Q491	R:R:Y487	4.51	Yes	No	0	4	4
345	R:R:I509	R:R:Y487	12.09	No	No	0	4	4
346	R:R:C490	R:R:C507	7.28	No	No	0	9	9
347	R:R:I509	R:R:R512	5.01	No	No	0	4	6
348	R:R:K510	R:R:N511	4.2	No	Yes	0	4	4
349	R:R:L516	R:R:S514	4.5	No	No	0	4	7
350	R:R:E518	R:R:L515	5.3	Yes	Yes	0	7	5
351	R:R:E518	R:R:V517	5.7	Yes	No	0	7	6
352	R:R:E518	W:W:?1	15.86	Yes	Yes	1	7	0
353	R:R:N521	W:W:?1	6.85	Yes	Yes	1	8	0
354	R:R:M525	W:W:?1	4.23	No	Yes	0	5	0
355	R:R:G527	R:R:I530	3.53	No	Yes	0	5	7
356	R:R:T534	R:R:W537	7.28	No	No	0	7	8
357	R:R:L125	R:R:P142	3.28	No	No	0	7	8
358	R:R:L376	R:R:P306	3.28	No	No	0	8	5
359	R:R:L367	R:R:P368	3.28	No	No	0	5	9
360	R:R:E158	R:R:G162	3.27	No	No	0	7	3
361	R:R:E211	R:R:W206	3.27	No	Yes	0	5	4
362	R:R:C314	R:R:I293	3.27	No	No	0	9	8
363	R:R:C469	R:R:I520	3.27	No	No	0	7	5
364	R:R:A283	R:R:I317	3.25	No	No	0	5	7
365	R:R:A289	R:R:M286	3.22	No	No	0	7	4
366	R:R:V333	R:R:V414	3.21	No	No	0	9	5
367	R:R:S96	R:R:T90	3.2	Yes	No	0	6	5
368	R:R:R296	R:R:R302	3.2	Yes	No	0	6	6
369	R:R:G435	R:R:H433	3.18	No	No	0	5	8
370	R:R:T150	R:R:V121	3.17	Yes	No	0	7	7
371	R:R:A272	R:R:L249	3.15	No	No	0	4	6
372	R:R:E71	R:R:P72	3.14	No	No	0	7	4
373	R:R:I509	R:R:S483	3.1	No	No	0	4	7
374	R:R:F523	R:R:Y233	3.09	No	Yes	0	6	6
375	R:R:I293	R:R:V294	3.07	No	No	0	8	8
376	R:R:H63	R:R:P175	3.05	No	No	0	3	5
377	R:R:F187	R:R:G80	3.01	Yes	No	0	6	5
378	R:R:F526	R:R:G238	3.01	Yes	No	0	9	7
379	R:R:F467	R:R:G409	3.01	No	No	0	7	4
380	R:R:F462	R:R:G527	3.01	No	No	0	7	5
381	R:R:M532	R:R:T528	3.01	Yes	No	0	8	7
382	R:R:L79	R:R:S110	3	Yes	No	0	5	5
383	R:R:K204	R:R:T307	3	No	No	0	3	6
384	R:R:L303	R:R:S205	3	No	No	0	3	7
385	R:R:L410	R:R:V414	2.98	No	No	0	4	5
386	R:R:L452	R:R:V423	2.98	Yes	No	0	8	7
387	R:R:D95	R:R:S96	2.94	No	Yes	0	5	6
388	R:R:I317	R:R:I320	2.94	No	No	0	7	5
389	R:R:I429	R:R:I445	2.94	No	No	3	7	9
390	R:R:I420	R:R:M424	2.92	No	No	0	5	5
391	R:R:D473	R:R:V517	2.92	No	No	0	8	6
392	R:R:Q351	R:R:S354	2.89	No	No	0	7	7
393	R:R:Q183	R:R:V182	2.87	No	No	0	5	4
394	R:R:E292	R:R:S313	2.87	No	No	0	5	7
395	R:R:E439	R:R:S443	2.87	No	No	0	5	6
396	R:R:Q491	R:R:V494	2.87	Yes	No	0	4	5
397	R:R:E305	R:R:V315	2.85	No	No	0	7	7
398	R:R:E140	R:R:T179	2.82	Yes	No	0	5	4
399	R:R:K395	R:R:L303	2.82	No	No	0	3	3
400	R:R:M449	R:R:N446	2.8	No	No	0	9	7
401	R:R:C295	R:R:R291	2.79	No	No	0	9	5
402	R:R:P263	R:R:Y262	2.78	No	Yes	0	9	9
403	R:R:A93	R:R:F166	2.77	No	Yes	0	5	6
404	R:R:A264	R:R:F252	2.77	No	No	0	9	9
405	R:R:M131	R:R:Q99	2.72	Yes	No	0	5	9
406	R:R:E479	R:R:N511	2.63	No	Yes	0	2	4
407	R:R:F247	R:R:V536	2.62	No	No	0	8	8
408	R:R:F252	R:R:V536	2.62	No	No	0	9	8
409	R:R:C273	R:R:W331	2.61	No	Yes	6	9	9
410	R:R:C273	R:R:W365	2.61	No	Yes	6	9	9
411	R:R:R173	R:R:T170	2.59	No	No	0	4	6
412	R:R:S190	R:R:W119	2.47	No	Yes	0	6	9
413	R:R:G415	R:R:G416	2.11	No	No	0	8	5
414	R:R:C496	R:R:G497	1.96	No	No	0	4	3
415	R:R:A324	R:R:G277	1.95	No	No	0	7	6
416	R:R:A401	R:R:G402	1.95	No	No	0	6	5
417	R:R:A68	R:R:P69	1.87	No	No	0	5	4
418	R:R:A115	R:R:P116	1.87	No	No	0	6	9
419	R:R:A379	R:R:P306	1.87	No	No	0	6	5
420	R:R:A406	R:R:P407	1.87	No	No	0	5	9
421	R:R:G355	R:R:S354	1.86	No	No	0	6	7
422	R:R:G104	R:R:V107	1.84	No	No	0	4	4
423	R:R:G299	R:R:V198	1.84	No	No	0	4	6
424	R:R:G393	R:R:V392	1.84	No	No	0	9	9
425	R:R:G347	R:R:T348	1.82	No	No	0	7	7
426	R:R:A87	R:R:C70	1.81	No	No	9	4	9
427	R:R:A87	R:R:C134	1.81	No	No	9	4	9
428	R:R:G280	R:R:I279	1.76	No	No	0	7	5
429	R:R:C70	R:R:S89	1.72	No	No	0	9	8
430	R:R:G456	R:R:L419	1.71	No	No	0	7	7
431	R:R:A441	R:R:S438	1.71	No	No	0	8	8
432	R:R:G461	R:R:L464	1.71	No	No	0	5	4
433	R:R:A149	R:R:T150	1.68	No	Yes	0	4	7
434	R:R:D287	R:R:G288	1.68	No	No	0	5	6
435	R:R:D298	R:R:G299	1.68	Yes	No	0	7	4
436	R:R:L353	R:R:P352	1.64	No	Yes	0	8	7
437	R:R:C469	R:R:I465	1.64	No	No	0	7	5
438	R:R:A338	R:R:I266	1.62	No	Yes	0	8	8
439	R:R:A289	R:R:I293	1.62	No	No	0	7	8
440	R:R:A524	R:R:I465	1.62	No	No	0	7	5
441	R:R:D137	R:R:P69	1.61	No	No	0	4	4
442	R:R:A442	R:R:K430	1.61	No	No	0	8	8
443	R:R:S313	R:R:T311	1.6	No	No	0	7	7
444	R:R:S358	R:R:T357	1.6	No	No	0	6	6
445	R:R:C496	R:R:L108	1.59	No	No	0	4	5
446	R:R:G422	R:R:H340	1.59	No	Yes	0	8	7
447	R:R:P352	R:R:Q351	1.58	Yes	No	0	7	7
448	R:R:A531	R:R:L458	1.58	No	No	0	6	6
449	R:R:A492	R:R:N114	1.56	No	No	0	5	5
450	R:R:I530	R:R:V240	1.54	Yes	No	0	7	4
451	R:R:K440	R:R:S438	1.53	No	No	0	6	8
452	R:R:C507	R:R:Q491	1.53	No	Yes	0	9	4
453	R:R:A297	R:R:E310	1.51	No	No	0	5	8
454	R:R:F460	R:R:G461	1.51	No	No	0	5	5
455	R:R:L363	R:R:S366	1.5	No	No	0	4	7
456	R:R:L79	R:R:V77	1.49	Yes	No	0	5	5
457	R:R:L367	R:R:V370	1.49	No	No	0	5	5
458	R:R:D229	R:R:S232	1.47	No	No	0	6	4
459	R:R:D255	R:R:S259	1.47	No	No	0	8	8
460	R:R:L426	R:R:T448	1.47	Yes	No	0	9	8
461	R:R:I429	R:R:L426	1.43	No	Yes	3	7	9
462	R:R:I445	R:R:L426	1.43	No	Yes	3	9	9
463	R:R:I445	R:R:L437	1.43	No	No	0	9	6
464	R:R:A459	R:R:F332	1.39	No	Yes	0	7	9
465	R:R:P352	R:R:Y350	1.39	Yes	No	0	7	7
466	R:R:L363	R:R:L367	1.38	No	No	0	4	5
467	R:R:E160	R:R:I156	1.37	Yes	No	0	4	5
468	R:R:D255	R:R:N258	1.35	No	No	0	8	8
469	R:R:T348	R:R:Y350	1.25	No	No	0	7	7
470	R:R:K356	R:R:Y359	1.19	No	No	0	8	7
471	R:R:E447	R:R:R451	1.16	No	No	0	6	9
472	R:R:F474	R:R:F475	1.07	Yes	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L79	4.315	4	0	5
2	R:R:L91	5.902	5	7	5
3	R:R:L92	6.34	4	7	8
4	R:R:S96	4.545	4	0	6
5	R:R:K105	8.8275	4	2	4
6	R:R:W109	7.405	6	2	7
7	R:R:W119	14.395	4	0	9
8	R:R:Y130	7.262	5	2	7
9	R:R:M131	5.5475	4	0	5
10	R:R:E140	5.2025	4	8	5
11	R:R:T150	3.3225	4	0	7
12	R:R:R151	6.365	4	2	5
13	R:R:E160	5.65	4	11	4
14	R:R:W163	6.89667	6	2	8
15	R:R:F166	7.00667	6	0	6
16	R:R:I185	4.4325	4	4	4
17	R:R:F187	9.87333	6	4	6
18	R:R:N202	7.4475	4	12	5
19	R:R:W206	5.684	5	0	4
20	R:R:Y207	6.442	5	5	7
21	R:R:F222	5.91143	7	1	6
22	R:R:H227	5.345	6	1	7
23	R:R:Y233	11.6625	4	0	6
24	R:R:Y262	7.07667	6	0	9
25	R:R:I266	5.71	4	0	8
26	R:R:F268	7.445	4	0	8
27	R:R:Y269	11.1525	4	6	8
28	R:R:W281	5.11667	6	0	7
29	R:R:F285	6.885	4	13	8
30	R:R:R296	7.19	5	12	6
31	R:R:D298	5.395	4	0	7
32	R:R:F318	6.595	4	1	9
33	R:R:Y322	6.205	6	1	9
34	R:R:M326	4.7725	4	1	8
35	R:R:W331	13.7967	6	6	9
36	R:R:F332	5.1475	4	16	9
37	R:R:W339	10.11	4	3	9
38	R:R:H340	4.25	4	0	7
39	R:R:P352	2.9	4	0	7
40	R:R:F360	6.9575	4	15	9
41	R:R:H361	8.06	4	6	9
42	R:R:W365	8.8875	4	6	9
43	R:R:I375	6.115	4	1	7
44	R:R:D384	7.926	5	1	8
45	R:R:Y394	11.135	4	1	5
46	R:R:Y399	11.02	4	17	5
47	R:R:L426	3.42	5	3	9
48	R:R:L452	3.835	4	3	8
49	R:R:H470	8.59	5	1	7
50	R:R:F474	4.185	4	0	6
51	R:R:W480	12.145	4	0	9
52	R:R:F484	6.178	5	5	6
53	R:R:Q491	3.5025	4	0	4
54	R:R:N511	4.045	4	0	4
55	R:R:L515	5.4125	4	0	5
56	R:R:E518	7.88	4	1	7
57	R:R:N521	7.085	4	1	8
58	R:R:F526	5.54	4	0	9
59	R:R:I530	3.635	4	0	7
60	R:R:M532	5.625	4	16	8
61	R:R:W535	12.63	4	0	9
62	W:W:?1	9.94333	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M131	R:R:Y85	16.079	4.79	Yes	No	0	5	9
2	R:R:M131	R:R:T88	13.1225	9.03	Yes	No	0	5	9
3	R:R:P132	R:R:T88	12.7502	3.5	No	No	0	9	9
4	R:R:M131	R:R:Q99	20.8488	2.72	Yes	No	0	5	9
5	R:R:Q99	R:R:Y75	20.7788	5.64	No	No	0	9	3
6	R:R:H103	R:R:Y75	20.6912	13.07	No	No	0	5	3
7	R:R:I185	R:R:P84	10.6653	3.39	Yes	No	4	4	4
8	R:R:P84	R:R:Y85	11.5807	6.95	No	No	0	4	9
9	R:R:H103	R:R:V107	20.6342	6.92	No	No	0	5	4
10	R:R:L79	R:R:V107	20.4941	4.47	Yes	No	0	5	4
11	R:R:L106	R:R:L79	20.1875	8.3	No	Yes	0	8	5
12	R:R:L106	R:R:L126	20.0736	4.15	No	No	0	8	9
13	R:R:L126	R:R:W109	12.3166	6.83	No	Yes	2	9	7
14	R:R:N202	R:R:S205	12.829	7.45	Yes	No	12	5	7
15	R:R:L303	R:R:S205	51.1541	3	No	No	0	3	7
16	R:R:D382	R:R:L303	53.3441	4.07	No	No	0	9	3
17	R:R:D382	R:R:Y394	54.426	10.34	No	Yes	0	9	5
18	R:R:Y394	W:W:?1	27.1692	18.7	Yes	Yes	1	5	0
19	R:R:F222	W:W:?1	61.18	4.86	Yes	Yes	1	6	0
20	R:R:F222	R:R:P513	54.7282	8.67	Yes	No	0	6	8
21	R:R:L221	R:R:P513	30.4454	6.57	No	No	0	6	8
22	R:R:F484	R:R:L221	29.1533	3.65	Yes	No	0	6	6
23	R:R:F484	R:R:Y207	21.1511	8.25	Yes	Yes	5	6	7
24	R:R:L197	R:R:Y207	10.1441	3.52	No	Yes	0	9	7
25	R:R:Q491	R:R:Y487	11.5588	4.51	Yes	No	0	4	4
26	R:R:I509	R:R:Y487	12.9648	12.09	No	No	0	4	4
27	R:R:I509	R:R:S483	17.1302	3.1	No	No	0	4	7
28	R:R:N511	R:R:S483	18.5012	5.96	Yes	No	0	4	7
29	R:R:N511	R:R:W480	22.5614	3.39	Yes	Yes	0	4	9
30	R:R:P513	R:R:W480	27.6291	28.38	No	Yes	0	8	9
31	R:R:R296	R:R:S205	37.2126	7.91	Yes	No	12	6	7
32	R:R:C314	R:R:I293	10.1134	3.27	No	No	0	9	8
33	R:R:C314	R:R:E305	14.3183	6.08	No	No	0	9	7
34	R:R:E305	R:R:R302	22.4914	12.79	No	No	0	7	6
35	R:R:R296	R:R:R302	27.7649	3.2	Yes	No	0	6	6
36	R:R:F222	R:R:H227	11.699	3.39	Yes	Yes	1	6	7
37	R:R:M525	W:W:?1	41.0407	4.23	No	Yes	0	5	0
38	R:R:M525	R:R:W281	39.2887	6.98	No	Yes	0	5	7
39	R:R:F526	R:R:W281	26.8714	6.01	Yes	Yes	0	9	7
40	R:R:F526	R:R:T241	24.055	7.78	Yes	No	0	9	7
41	R:R:I530	R:R:T241	22.0709	4.56	Yes	No	0	7	7
42	R:R:F268	R:R:L249	11.0332	3.65	Yes	No	0	8	6
43	R:R:F268	R:R:Y269	46.923	6.19	Yes	Yes	0	8	8
44	R:R:W331	R:R:Y269	26.8013	21.22	Yes	Yes	6	9	8
45	R:R:W331	R:R:W365	44.6323	17.81	Yes	Yes	6	9	9
46	R:R:W365	R:R:Y323	91.77	7.72	Yes	No	0	9	8
47	R:R:P368	R:R:Y323	92.4883	5.56	No	No	0	9	8
48	R:R:M326	R:R:P368	94.2184	3.35	Yes	No	0	8	9
49	R:R:M326	R:R:Y322	94.7002	4.79	Yes	Yes	1	8	9
50	R:R:F391	R:R:Y322	100	6.19	No	Yes	1	8	9
51	R:R:F391	W:W:?1	72.66	4.86	No	Yes	1	8	0
52	R:R:H361	R:R:Y269	24.1733	10.89	Yes	Yes	6	9	8
53	R:R:H361	R:R:W365	45.2367	7.41	Yes	Yes	6	9	9
54	R:R:F252	R:R:V536	17.5507	2.62	No	No	0	9	8
55	R:R:F252	R:R:F268	30.3491	13.93	No	Yes	0	9	8
56	R:R:A264	R:R:F252	11.0332	2.77	No	No	0	9	9
57	R:R:I266	R:R:W331	27.3313	7.05	Yes	Yes	0	8	9
58	R:R:H361	R:R:Y262	26.6086	6.53	Yes	Yes	0	9	9
59	R:R:L353	R:R:Y262	11.8611	3.52	No	Yes	0	8	9
60	R:R:F360	R:R:Y262	16.9068	6.19	Yes	Yes	0	9	9
61	R:R:I266	R:R:L335	30.4849	5.71	Yes	No	0	8	8
62	R:R:L335	R:R:W339	29.6614	20.5	No	Yes	0	8	9
63	R:R:W339	R:R:W535	13.5211	9.37	Yes	Yes	0	9	9
64	R:R:G527	R:R:I530	20.7831	3.53	No	Yes	0	5	7
65	R:R:F462	R:R:G527	20.3495	3.01	No	No	0	7	5
66	R:R:F462	R:R:T528	19.0881	6.49	No	No	0	7	7
67	R:R:M532	R:R:T528	17.4149	3.01	Yes	No	0	8	7
68	R:R:F455	R:R:M532	11.0946	4.98	No	Yes	16	8	8
69	R:R:F455	R:R:W535	11.7297	20.04	No	Yes	0	8	9
70	R:R:I375	R:R:Y322	12.4524	6.04	Yes	Yes	1	7	9
71	R:R:F360	R:R:Y337	11.7822	5.16	Yes	No	15	9	7
72	R:R:F418	R:R:Y337	10.5777	14.44	No	No	0	8	7
73	R:R:F343	R:R:W339	16.2805	6.01	No	Yes	3	9	9
74	R:R:L353	R:R:P352	10.5777	1.64	No	Yes	0	8	7
75	R:R:F343	R:R:L426	15.5534	8.53	No	Yes	3	9	9
76	R:R:H470	R:R:L405	19.3728	9	Yes	No	0	7	8
77	R:R:H470	W:W:?1	21.5803	16.67	Yes	Yes	1	7	0
78	R:R:E518	W:W:?1	12.1063	15.86	Yes	Yes	1	7	0
79	R:R:F391	R:R:Y394	27.5809	5.16	No	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F222	R:R:N219	3.62	1	Yes	No	6	7	1	2
R:R:D384	R:R:N219	8.08	1	Yes	No	8	7	1	2
R:R:E226	R:R:F222	7	0	No	Yes	8	6	2	1
R:R:F222	R:R:H227	3.39	1	Yes	Yes	6	7	1	2
R:R:F222	R:R:V386	9.18	1	Yes	No	6	5	1	2
R:R:F222	R:R:P513	8.67	1	Yes	No	6	8	1	2
R:R:E518	R:R:F222	4.66	1	Yes	Yes	7	6	1	1
R:R:F222	W:W:?1	4.86	1	Yes	Yes	6	0	1	0
R:R:E226	R:R:L515	6.63	0	No	Yes	8	5	2	2
R:R:H227	R:R:V386	8.3	1	Yes	No	7	5	2	2
R:R:M525	R:R:W281	6.98	0	No	Yes	5	7	1	2
R:R:F391	R:R:Y322	6.19	1	No	Yes	8	9	1	2
R:R:L325	R:R:M525	5.65	0	No	No	5	5	2	1
R:R:I408	R:R:V329	4.61	0	No	No	7	6	1	2
R:R:D382	R:R:Y394	10.34	0	No	Yes	9	5	2	1
R:R:D384	R:R:V386	4.38	1	Yes	No	8	5	1	2
R:R:D384	R:R:S387	7.36	1	Yes	No	8	8	1	1
R:R:D384	R:R:Y394	10.34	1	Yes	Yes	8	5	1	1
R:R:D384	W:W:?1	9.47	1	Yes	Yes	8	0	1	0
R:R:S387	W:W:?1	8.98	1	No	Yes	8	0	1	0
R:R:F391	R:R:Y394	5.16	1	No	Yes	8	5	1	1
R:R:F391	W:W:?1	4.86	1	No	Yes	8	0	1	0
R:R:Y394	W:W:?1	18.7	1	Yes	Yes	5	0	1	0
R:R:R400	W:W:?1	15.75	0	No	Yes	9	0	1	0
R:R:H470	R:R:V404	4.15	1	Yes	No	7	7	1	2
R:R:H470	R:R:L405	9	1	Yes	No	7	8	1	2
R:R:I408	W:W:?1	4.27	0	No	Yes	7	0	1	0
R:R:H470	R:R:T466	5.48	1	Yes	No	7	8	1	1
R:R:N521	R:R:T466	4.39	1	Yes	No	8	8	1	1
R:R:T466	W:W:?1	8.82	1	No	Yes	8	0	1	0
R:R:C469	R:R:N521	9.45	0	No	Yes	7	8	2	1
R:R:H470	R:R:N521	7.65	1	Yes	Yes	7	8	1	1
R:R:H470	W:W:?1	16.67	1	Yes	Yes	7	0	1	0
R:R:E518	R:R:L515	5.3	1	Yes	Yes	7	5	1	2
R:R:E518	R:R:V517	5.7	1	Yes	No	7	6	1	2
R:R:E518	W:W:?1	15.86	1	Yes	Yes	7	0	1	0
R:R:N521	W:W:?1	6.85	1	Yes	Yes	8	0	1	0
R:R:M525	W:W:?1	4.23	0	No	Yes	5	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XBK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	428
Number of Links	472
Number of Hubs	62
Number of Links mediated by Hubs	244
Number of Communities	17
Number of Nodes involved in Communities	88
Number of Links involved in Communities	112

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	60146
Length Of Smallest Path	3
Average Path Length	13.1442
Length of Longest Path	29
Minimum Path Strength	1.32
Average Path Strength	6.97888
Maximum Path Strength	32.71
Minimum Path Correlation	0.7
Average Path Correlation	0.963145
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	73.796
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6729
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6XBK_nogp_Chain_R H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S C L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T C G D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6XBK_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.