psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G191	R:R:S190	3.71	No	No	0	5	6
2	R:R:E194	R:R:Q192	10.19	Yes	No	0	6	4
3	R:R:C193	R:R:R199	12.54	No	No	0	9	4
4	R:R:C193	R:R:C213	7.28	No	No	0	9	9
5	R:R:E194	R:R:L197	6.63	Yes	No	5	6	9
6	R:R:E194	R:R:Q491	10.19	Yes	Yes	5	6	4
7	R:R:P196	R:R:V195	5.3	No	No	0	7	4
8	R:R:P196	R:R:Q491	18.95	No	Yes	0	7	4
9	R:R:C213	R:R:L197	7.94	No	No	0	9	9
10	R:R:L197	R:R:Q491	7.99	No	Yes	5	9	4
11	R:R:T200	R:R:W206	8.49	No	Yes	6	6	4
12	R:R:G214	R:R:T200	5.46	No	No	6	8	6
13	R:R:D298	R:R:T200	7.23	No	No	0	7	6
14	R:R:N202	R:R:P203	4.89	No	No	0	5	4
15	R:R:K204	R:R:N202	16.79	No	No	0	3	5
16	R:R:P203	R:R:W206	14.86	No	Yes	0	4	4
17	R:R:S205	R:R:T300	9.59	No	No	0	7	7
18	R:R:E208	R:R:W206	4.36	No	Yes	0	4	4
19	R:R:G212	R:R:W206	4.22	No	Yes	0	7	4
20	R:R:G214	R:R:W206	5.63	No	Yes	6	8	4
21	R:R:D209	R:R:Y207	10.34	No	Yes	0	4	7
22	R:R:I215	R:R:Y207	3.63	No	Yes	0	5	7
23	R:R:F484	R:R:Y207	7.22	No	Yes	0	6	7
24	R:R:V488	R:R:Y207	10.09	No	Yes	0	6	7
25	R:R:E211	R:R:G212	4.91	No	No	0	5	7
26	R:R:I215	R:R:T300	7.6	No	No	0	5	7
27	R:R:I215	R:R:M301	2.92	No	No	0	5	4
28	R:R:Q216	R:R:Q218	16.64	No	No	0	7	5
29	R:R:P220	R:R:Q216	4.74	No	No	0	8	7
30	R:R:C217	R:R:C295	3.64	No	No	0	9	9
31	R:R:Q218	R:R:R291	8.18	No	No	0	5	5
32	R:R:Q218	R:R:S385	2.89	No	No	0	5	7
33	R:R:D384	R:R:N219	4.04	No	No	8	8	7
34	R:R:N219	R:R:V386	7.39	No	Yes	8	7	5
35	R:R:L221	R:R:P220	3.28	No	No	0	6	8
36	R:R:L221	R:R:P513	8.21	No	No	0	6	8
37	R:R:E226	R:R:F222	4.66	No	No	0	8	6
38	R:R:F222	R:R:V386	2.62	No	Yes	0	6	5
39	R:R:F222	R:R:P513	5.78	No	No	0	6	8
40	R:R:E226	R:R:T223	8.47	No	No	0	8	5
41	R:R:E224	R:R:H227	3.69	No	No	0	4	7
42	R:R:E226	R:R:L515	2.65	No	No	0	8	5
43	R:R:H227	R:R:V386	4.15	No	Yes	0	7	5
44	R:R:D229	R:R:M230	2.77	No	No	9	6	7
45	R:R:D229	R:R:Y233	3.45	No	Yes	9	6	6
46	R:R:M230	R:R:Y233	3.59	No	Yes	9	7	6
47	R:R:H231	R:R:Q284	12.36	No	No	0	7	9
48	R:R:H231	R:R:R290	5.64	No	No	0	7	9
49	R:R:S232	R:R:Y233	3.82	No	Yes	0	4	6
50	R:R:K519	R:R:Y233	17.91	No	Yes	0	7	6
51	R:R:I234	R:R:W281	4.7	No	Yes	0	7	7
52	R:R:I234	R:R:Q284	6.86	No	No	0	7	9
53	R:R:A235	R:R:Q284	3.03	No	No	0	5	9
54	R:R:F237	R:R:F523	5.36	Yes	No	0	4	6
55	R:R:F237	R:R:F526	10.72	Yes	Yes	0	4	9
56	R:R:F526	R:R:G238	4.52	Yes	No	0	9	7
57	R:R:F526	R:R:T241	9.08	Yes	No	0	9	7
58	R:R:C244	R:R:S533	6.89	No	No	0	6	9
59	R:R:N271	R:R:T245	2.92	Yes	No	0	9	8
60	R:R:F275	R:R:T245	9.08	No	No	0	5	8
61	R:R:F247	R:R:W537	3.01	No	No	0	8	8
62	R:R:F247	R:R:W545	10.02	No	No	0	8	9
63	R:R:L249	R:R:T248	5.9	No	Yes	10	6	8
64	R:R:N271	R:R:T248	8.77	Yes	Yes	10	9	8
65	R:R:S533	R:R:T248	3.2	No	Yes	0	9	8
66	R:R:T248	R:R:V536	6.35	Yes	No	0	8	8
67	R:R:F268	R:R:L249	6.09	Yes	No	0	8	6
68	R:R:L249	R:R:N271	4.12	No	Yes	10	6	9
69	R:R:A250	R:R:W545	2.59	No	No	0	6	9
70	R:R:F252	R:R:T251	3.89	No	No	0	9	9
71	R:R:T251	R:R:T541	3.14	No	No	0	9	8
72	R:R:F252	R:R:S259	2.64	No	No	0	9	8
73	R:R:F252	R:R:F268	16.08	No	Yes	0	9	8
74	R:R:D255	R:R:N258	4.04	No	No	0	8	8
75	R:R:D255	R:R:I544	4.2	No	No	0	8	6
76	R:R:N260	R:R:W256	5.65	No	No	0	7	7
77	R:R:F268	R:R:W256	4.01	Yes	No	0	8	7
78	R:R:R261	R:R:S259	13.18	No	No	0	7	8
79	R:R:A264	R:R:R261	4.15	No	No	0	9	7
80	R:R:P263	R:R:Y262	6.95	No	No	0	9	9
81	R:R:T357	R:R:Y262	2.5	No	No	0	6	9
82	R:R:V265	R:R:Y269	2.52	No	Yes	0	8	8
83	R:R:I266	R:R:W331	8.22	No	Yes	0	8	9
84	R:R:I266	R:R:L335	4.28	No	No	0	8	8
85	R:R:L267	R:R:W535	7.97	No	Yes	0	8	9
86	R:R:F268	R:R:Y269	6.19	Yes	Yes	0	8	8
87	R:R:W331	R:R:Y269	20.26	Yes	Yes	11	9	8
88	R:R:H361	R:R:Y269	5.44	No	Yes	11	9	8
89	R:R:N271	R:R:V270	2.96	Yes	No	0	9	8
90	R:R:M532	R:R:V270	6.09	No	No	0	8	8
91	R:R:A327	R:R:C273	3.61	No	No	0	9	9
92	R:R:C273	R:R:W331	2.61	No	Yes	0	9	9
93	R:R:F274	R:R:M525	2.49	No	Yes	0	9	5
94	R:R:F274	R:R:T528	3.89	No	No	0	9	7
95	R:R:F274	R:R:G529	6.02	No	No	0	9	9
96	R:R:F275	R:R:I279	3.77	No	No	0	5	5
97	R:R:I279	R:R:L282	2.85	No	No	0	5	7
98	R:R:V321	R:R:W281	3.68	No	Yes	0	8	7
99	R:R:I389	R:R:W281	17.62	No	Yes	0	9	7
100	R:R:M525	R:R:W281	6.98	Yes	Yes	1	5	7
101	R:R:F526	R:R:W281	4.01	Yes	Yes	1	9	7
102	R:R:A289	R:R:M286	3.22	No	No	0	7	4
103	R:R:D287	R:R:G288	3.35	No	No	13	5	6
104	R:R:D287	R:R:E292	3.9	No	No	13	5	5
105	R:R:E292	R:R:G288	6.55	No	No	13	5	6
106	R:R:C295	R:R:R291	2.79	No	No	0	9	5
107	R:R:D298	R:R:R296	5.96	No	Yes	0	7	6
108	R:R:L303	R:R:R296	3.64	No	Yes	0	3	6
109	R:R:R296	R:R:S308	9.22	Yes	No	0	6	8
110	R:R:E310	R:R:R296	10.47	No	Yes	0	8	6
111	R:R:D382	R:R:M301	2.77	No	No	0	9	4
112	R:R:E310	R:R:R302	15.12	No	No	0	8	6
113	R:R:R302	R:R:S313	5.27	No	No	0	6	7
114	R:R:C314	R:R:R302	6.96	No	No	0	9	6
115	R:R:D382	R:R:L303	2.71	No	No	0	9	3
116	R:R:E305	R:R:P306	7.86	No	No	0	7	5
117	R:R:E305	R:R:Q380	12.74	No	No	0	7	7
118	R:R:S313	R:R:T311	3.2	No	No	0	7	7
119	R:R:C314	R:R:V315	3.42	No	No	0	9	7
120	R:R:I317	R:R:I320	2.94	No	No	0	7	5
121	R:R:I317	R:R:V321	3.07	No	No	0	7	8
122	R:R:F318	R:R:I375	3.77	Yes	No	0	9	7
123	R:R:F318	R:R:V381	3.93	Yes	No	0	9	8
124	R:R:C390	R:R:F318	2.79	No	Yes	0	9	9
125	R:R:F318	R:R:F391	13.93	Yes	No	0	9	8
126	R:R:M326	R:R:Y322	5.99	No	Yes	3	8	9
127	R:R:L371	R:R:Y322	5.86	Yes	Yes	3	8	9
128	R:R:T372	R:R:Y322	2.5	No	Yes	0	9	9
129	R:R:I375	R:R:Y322	7.25	No	Yes	0	7	9
130	R:R:W365	R:R:Y323	4.82	No	No	0	9	8
131	R:R:P368	R:R:Y323	6.95	No	No	0	9	8
132	R:R:L325	R:R:M326	4.24	No	No	0	5	8
133	R:R:L371	R:R:M326	7.07	Yes	No	3	8	8
134	R:R:V329	R:R:V411	4.81	No	No	0	6	5
135	R:R:T364	R:R:V330	6.35	No	No	0	9	6
136	R:R:L367	R:R:V330	2.98	Yes	No	0	5	6
137	R:R:V334	R:R:W331	2.45	No	Yes	0	7	9
138	R:R:H361	R:R:W331	8.46	No	Yes	11	9	9
139	R:R:T364	R:R:W331	18.19	No	Yes	0	9	9
140	R:R:F332	R:R:F455	3.22	No	Yes	12	9	8
141	R:R:F332	R:R:M532	3.73	No	No	12	9	8
142	R:R:T336	R:R:V333	3.17	Yes	No	0	7	9
143	R:R:V333	R:R:V411	8.02	No	No	0	9	5
144	R:R:F360	R:R:V334	6.55	No	No	0	9	7
145	R:R:L335	R:R:W339	20.5	No	No	0	8	9
146	R:R:G415	R:R:T336	5.46	No	Yes	0	8	7
147	R:R:F418	R:R:T336	3.89	Yes	Yes	0	8	7
148	R:R:L419	R:R:T336	2.95	No	Yes	0	7	7
149	R:R:H340	R:R:Y337	4.36	No	Yes	4	7	7
150	R:R:T341	R:R:Y337	3.75	No	Yes	4	6	7
151	R:R:F360	R:R:Y337	4.13	No	Yes	0	9	7
152	R:R:F418	R:R:Y337	6.19	Yes	Yes	4	8	7
153	R:R:F343	R:R:W339	5.01	Yes	No	0	9	9
154	R:R:W339	R:R:W535	8.43	No	Yes	0	9	9
155	R:R:H340	R:R:T341	6.85	No	No	4	7	6
156	R:R:F418	R:R:H340	28.28	Yes	No	4	8	7
157	R:R:F343	R:R:S342	6.61	Yes	No	0	9	8
158	R:R:F343	R:R:L346	6.09	Yes	No	0	9	6
159	R:R:F343	R:R:L426	4.87	Yes	No	0	9	9
160	R:R:G347	R:R:Y350	2.9	No	No	0	7	7
161	R:R:Q351	R:R:Y350	5.64	No	No	0	7	7
162	R:R:L353	R:R:Q351	6.65	No	No	0	8	7
163	R:R:P352	R:R:S354	3.56	No	No	0	7	7
164	R:R:H361	R:R:W365	13.75	No	No	0	9	9
165	R:R:L367	R:R:P368	3.28	Yes	No	0	5	9
166	R:R:L367	R:R:L371	2.77	Yes	Yes	3	5	8
167	R:R:F369	R:R:V373	2.62	No	No	0	7	7
168	R:R:V381	R:R:V392	4.81	No	No	0	8	9
169	R:R:D384	R:R:V386	5.84	No	Yes	8	8	5
170	R:R:D384	R:R:S387	8.83	No	No	0	8	8
171	R:R:G388	R:R:S387	3.71	No	No	0	9	8
172	R:R:I389	R:R:S387	6.19	No	No	0	9	8
173	R:R:F391	R:R:I389	2.51	No	No	0	8	9
174	R:R:F391	W:W:?1	20.1	No	Yes	0	8	0
175	R:R:G393	R:R:V392	3.68	No	No	0	9	9
176	R:R:G393	R:R:R400	3	No	Yes	1	9	9
177	R:R:G393	W:W:?1	4.03	No	Yes	1	9	0
178	R:R:K395	R:R:Y394	16.72	No	No	7	3	5
179	R:R:F484	R:R:Y394	7.22	No	No	7	6	5
180	R:R:F484	R:R:K395	3.72	No	No	7	6	3
181	R:R:N396	R:R:R398	3.62	No	No	14	7	1
182	R:R:N396	R:R:Y399	12.79	No	No	14	7	5
183	R:R:F474	R:R:Y397	3.09	No	No	15	6	3
184	R:R:Q477	R:R:Y397	12.4	No	No	15	6	3
185	R:R:R398	R:R:Y399	9.26	No	No	14	1	5
186	R:R:R400	R:R:V404	5.23	Yes	No	1	9	7
187	R:R:L405	R:R:R400	4.86	No	Yes	1	8	9
188	R:R:H470	R:R:R400	7.9	No	Yes	1	7	9
189	R:R:R400	W:W:?1	9.55	Yes	Yes	1	9	0
190	R:R:L405	R:R:V404	2.98	No	No	1	8	7
191	R:R:F467	R:R:G409	3.01	No	No	0	7	4
192	R:R:I413	R:R:L412	2.85	No	No	0	3	7
193	R:R:L412	R:R:V463	5.96	No	No	0	7	7
194	R:R:F418	R:R:V414	3.93	Yes	No	0	8	5
195	R:R:F418	R:R:Y417	4.13	Yes	No	0	8	5
196	R:R:R421	R:R:Y417	11.32	No	No	0	7	5
197	R:R:I420	R:R:R421	3.76	No	No	0	5	7
198	R:R:L452	R:R:V423	2.98	No	No	0	8	7
199	R:R:I445	R:R:L426	2.85	No	No	0	9	9
200	R:R:L426	R:R:M449	7.07	No	No	0	9	9
201	R:R:F427	R:R:K430	7.44	No	No	0	7	8
202	R:R:F427	R:R:M449	3.73	No	No	0	7	9
203	R:R:H433	R:R:S428	4.18	No	No	0	8	5
204	R:R:I429	R:R:N432	8.5	No	No	0	7	6
205	R:R:N432	R:R:P434	14.66	No	No	0	6	7
206	R:R:L437	R:R:N432	2.75	No	No	0	6	6
207	R:R:H433	R:R:P434	7.63	No	No	0	8	7
208	R:R:L437	R:R:S438	9.01	No	No	0	6	8
209	R:R:A441	R:R:S438	3.42	No	No	0	8	8
210	R:R:K440	R:R:K444	10.06	No	No	0	6	9
211	R:R:A441	R:R:K444	3.21	No	No	0	8	9
212	R:R:I445	R:R:T448	3.04	No	No	0	9	8
213	R:R:R451	R:R:T534	7.76	No	No	0	9	7
214	R:R:R451	R:R:W535	10	No	Yes	0	9	9
215	R:R:A531	R:R:F455	4.16	No	Yes	0	6	8
216	R:R:F455	R:R:M532	4.98	Yes	No	12	8	8
217	R:R:F455	R:R:W535	23.05	Yes	Yes	0	8	9
218	R:R:F460	R:R:L464	7.31	No	No	0	5	4
219	R:R:G461	R:R:L464	5.13	No	No	0	5	4
220	R:R:F462	R:R:G527	4.52	No	No	0	7	5
221	R:R:F462	R:R:T528	2.59	No	No	0	7	7
222	R:R:T466	R:R:V463	3.17	No	No	0	8	7
223	R:R:A524	R:R:I465	3.25	No	No	0	7	5
224	R:R:N521	R:R:T466	11.7	Yes	No	0	8	8
225	R:R:C469	R:R:I520	3.27	No	No	0	7	5
226	R:R:C469	R:R:N521	6.3	No	Yes	0	7	8
227	R:R:H470	R:R:N521	2.55	No	Yes	1	7	8
228	R:R:H470	W:W:?1	4.04	No	Yes	1	7	0
229	R:R:N476	R:R:Y472	5.81	Yes	No	2	6	7
230	R:R:W480	R:R:Y472	2.89	Yes	No	2	9	7
231	R:R:S514	R:R:Y472	6.36	Yes	No	2	7	7
232	R:R:D473	R:R:Q477	11.75	No	No	0	8	6
233	R:R:F474	R:R:Q477	4.68	No	No	15	6	6
234	R:R:E479	R:R:N476	2.63	Yes	Yes	2	2	6
235	R:R:N476	R:R:W480	32.77	Yes	Yes	2	6	9
236	R:R:N476	R:R:N511	5.45	Yes	Yes	2	6	4
237	R:R:E479	R:R:K510	2.7	Yes	No	0	2	4
238	R:R:E479	R:R:N511	14.46	Yes	Yes	2	2	4
239	R:R:S483	R:R:W480	2.47	No	Yes	2	7	9
240	R:R:N511	R:R:W480	9.04	Yes	Yes	2	4	9
241	R:R:P513	R:R:W480	5.4	No	Yes	0	8	9
242	R:R:S514	R:R:W480	4.94	Yes	Yes	2	7	9
243	R:R:I509	R:R:S483	3.1	Yes	No	0	4	7
244	R:R:N511	R:R:S483	2.98	Yes	No	2	4	7
245	R:R:Q491	R:R:V488	4.3	Yes	No	0	4	6
246	R:R:C490	R:R:C507	7.28	No	No	0	9	9
247	R:R:I496	R:R:N493	5.66	No	No	0	4	5
248	R:R:P505	R:R:V494	3.53	No	No	0	5	5
249	R:R:C507	R:R:V494	3.42	No	No	0	9	5
250	R:R:L498	R:R:T495	5.9	No	No	0	3	4
251	R:R:L498	R:R:P505	8.21	No	No	0	3	5
252	R:R:P499	R:R:Q502	11.05	No	No	0	3	4
253	R:R:I504	R:R:P505	3.39	No	No	0	3	5
254	R:R:I509	R:R:R512	2.51	Yes	No	0	4	6
255	R:R:S514	R:R:V517	4.85	Yes	No	0	7	6
256	R:R:L515	R:R:L516	5.54	No	No	0	5	4
257	R:R:N521	W:W:?1	12.95	Yes	Yes	1	8	0
258	R:R:F526	R:R:M525	2.49	Yes	Yes	1	9	5
259	R:R:M525	W:W:?1	11.11	Yes	Yes	1	5	0
260	R:R:G527	R:R:I530	5.29	No	No	0	5	7
261	R:R:A540	R:R:T538	3.36	No	No	0	8	8
262	R:R:T538	R:R:T541	4.71	No	No	0	8	8
263	R:R:I544	R:R:T541	3.04	No	No	0	6	8
264	R:R:R547	R:R:R551	5.33	No	No	0	6	7
265	R:R:R551	R:R:T548	10.35	No	No	0	7	6
266	R:R:F455	R:R:L458	2.44	Yes	No	0	8	6
267	R:R:T251	R:R:W545	2.43	No	No	0	9	9
268	R:R:L552	R:R:R551	2.43	No	No	0	4	7
269	R:R:I509	R:R:Y487	2.42	Yes	No	0	4	4
270	R:R:L353	R:R:Y262	2.34	No	No	0	8	9
271	R:R:E479	R:R:R482	2.33	Yes	No	0	2	3
272	R:R:L522	R:R:W281	2.28	No	Yes	0	7	7
273	R:R:L452	R:R:W535	2.28	No	Yes	0	8	9
274	R:R:D473	R:R:W480	2.23	No	Yes	0	8	9
275	R:R:G415	R:R:G416	2.11	No	No	0	8	5
276	R:R:G435	R:R:P434	2.03	No	No	0	5	7
277	R:R:C273	R:R:G328	1.96	No	No	0	9	8
278	R:R:C295	R:R:G299	1.96	No	No	0	9	4
279	R:R:C390	R:R:G383	1.96	No	No	0	9	8
280	R:R:A324	R:R:G277	1.95	No	No	0	7	6
281	R:R:A401	R:R:G402	1.95	No	No	0	6	5
282	R:R:A406	R:R:G402	1.95	No	No	0	5	5
283	R:R:A459	R:R:G456	1.95	No	No	0	7	7
284	R:R:A338	R:R:P263	1.87	No	No	0	8	9
285	R:R:A406	R:R:P407	1.87	No	No	0	5	9
286	R:R:G355	R:R:S354	1.86	No	No	0	6	7
287	R:R:G214	R:R:V198	1.84	No	No	0	8	6
288	R:R:G277	R:R:V321	1.84	No	No	0	6	8
289	R:R:G383	R:R:V294	1.84	No	No	0	8	8
290	R:R:G242	R:R:T245	1.82	No	No	0	4	8
291	R:R:G347	R:R:T348	1.82	No	No	0	7	7
292	R:R:G422	R:R:T425	1.82	No	No	0	8	7
293	R:R:G280	R:R:I317	1.76	No	No	0	7	7
294	R:R:G409	R:R:L412	1.71	No	No	0	4	7
295	R:R:A324	R:R:V276	1.7	No	No	0	7	5
296	R:R:I266	R:R:P263	1.69	No	No	0	8	9
297	R:R:A225	R:R:T223	1.68	No	No	0	4	5
298	R:R:A254	R:R:T548	1.68	No	No	0	8	6
299	R:R:D298	R:R:G299	1.68	No	No	0	7	4
300	R:R:D382	R:R:G383	1.68	No	No	0	9	8
301	R:R:A524	R:R:T466	1.68	No	No	0	7	8
302	R:R:L498	R:R:P499	1.64	No	No	0	3	3
303	R:R:A289	R:R:I293	1.62	No	No	0	7	8
304	R:R:A492	R:R:I496	1.62	No	No	0	5	4
305	R:R:S278	R:R:T241	1.6	No	No	0	8	7
306	R:R:S358	R:R:T357	1.6	No	No	0	6	6
307	R:R:V370	R:R:V373	1.6	No	No	0	5	7
308	R:R:A345	R:R:L353	1.58	No	No	0	7	8
309	R:R:P503	R:R:Q502	1.58	No	No	0	5	4
310	R:R:C490	R:R:D486	1.56	No	No	0	9	4
311	R:R:C507	R:R:D506	1.56	No	No	0	9	3
312	R:R:I465	R:R:S468	1.55	No	No	0	5	4
313	R:R:I293	R:R:V294	1.54	No	No	0	8	8
314	R:R:I316	R:R:V319	1.54	No	No	0	5	7
315	R:R:I320	R:R:V319	1.54	No	No	0	5	7
316	R:R:I408	R:R:V329	1.54	No	No	0	7	6
317	R:R:I408	R:R:V463	1.54	No	No	0	7	7
318	R:R:K444	R:R:S443	1.53	No	No	0	9	6
319	R:R:A225	R:R:Q228	1.52	No	No	0	4	3
320	R:R:A379	R:R:Q380	1.52	No	No	0	6	7
321	R:R:I544	R:R:T548	1.52	No	No	0	6	6
322	R:R:A492	R:R:E194	1.51	No	Yes	0	5	6
323	R:R:A478	R:R:E481	1.51	No	No	0	3	5
324	R:R:G288	R:R:R290	1.5	No	No	0	6	9
325	R:R:L312	R:R:V315	1.49	No	No	0	7	7
326	R:R:L367	R:R:V370	1.49	Yes	No	3	5	5
327	R:R:L371	R:R:V370	1.49	Yes	No	3	8	5
328	R:R:N396	R:R:V392	1.48	No	No	0	7	9
329	R:R:I429	R:R:I445	1.47	No	No	0	7	9
330	R:R:D209	R:R:V210	1.46	No	No	0	4	5
331	R:R:E518	R:R:S514	1.44	No	Yes	0	7	7
332	R:R:Q380	R:R:V378	1.43	No	No	0	7	5
333	R:R:I454	R:R:L458	1.43	No	No	0	6	6
334	R:R:I465	R:R:L464	1.43	No	No	0	5	4
335	R:R:E305	R:R:T307	1.41	No	No	0	7	6
336	R:R:K430	R:R:N446	1.4	No	No	0	8	7
337	R:R:M449	R:R:N446	1.4	No	No	0	9	7
338	R:R:D486	R:R:I509	1.4	No	Yes	0	4	4
339	R:R:A459	R:R:F332	1.39	No	No	0	7	9
340	R:R:D486	R:R:L489	1.36	No	No	0	4	4
341	R:R:E439	R:R:L436	1.33	No	No	0	5	6
342	R:R:F237	R:R:V240	1.31	Yes	No	0	4	4
343	R:R:T349	R:R:Y350	1.25	No	No	0	6	7
344	R:R:F237	R:R:K519	1.24	Yes	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E194	7.13	4	5	6
2	R:R:W206	7.512	5	6	4
3	R:R:Y207	7.82	4	0	7
4	R:R:Y233	7.1925	4	9	6
5	R:R:F237	4.6575	4	0	4
6	R:R:T248	6.055	4	10	8
7	R:R:F268	8.0925	4	0	8
8	R:R:Y269	8.6025	4	11	8
9	R:R:N271	4.6925	4	10	9
10	R:R:W281	6.545	6	1	7
11	R:R:R296	7.3225	4	0	6
12	R:R:F318	6.105	4	0	9
13	R:R:Y322	5.4	4	3	9
14	R:R:W331	10.0317	6	11	9
15	R:R:T336	3.8675	4	0	7
16	R:R:Y337	4.6075	4	4	7
17	R:R:F343	5.645	4	0	9
18	R:R:L367	2.63	4	3	5
19	R:R:L371	4.2975	4	3	8
20	R:R:V386	5	4	8	5
21	R:R:R400	6.108	5	1	9
22	R:R:F418	9.284	5	4	8
23	R:R:F455	7.57	5	12	8
24	R:R:N476	11.665	4	2	6
25	R:R:E479	5.53	4	2	2
26	R:R:W480	8.53429	7	2	9
27	R:R:Q491	10.3575	4	5	4
28	R:R:I509	2.3575	4	0	4
29	R:R:N511	7.9825	4	2	4
30	R:R:S514	4.3975	4	2	7
31	R:R:N521	8.375	4	1	8
32	R:R:M525	5.7675	4	1	5
33	R:R:F526	6.164	5	1	9
34	R:R:W535	10.346	5	0	9
35	W:W:?1	10.2967	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q491	R:R:V488	17.3775	4.3	Yes	No	0	4	6
2	R:R:V488	R:R:Y207	18.7074	10.09	No	Yes	0	6	7
3	R:R:I215	R:R:Y207	26.8222	3.63	No	Yes	0	5	7
4	R:R:I215	R:R:M301	30.77	2.92	No	No	0	5	4
5	R:R:D382	R:R:M301	32.0905	2.77	No	No	0	9	4
6	R:R:D382	R:R:L303	30.6346	2.71	No	No	0	9	3
7	R:R:L303	R:R:R296	29.7294	3.64	No	Yes	0	3	6
8	R:R:D298	R:R:R296	21.7499	5.96	No	Yes	0	7	6
9	R:R:D298	R:R:T200	14.6477	7.23	No	No	0	7	6
10	R:R:T200	R:R:W206	10.2846	8.49	No	Yes	6	6	4
11	R:R:D298	R:R:G299	11.3299	1.68	No	No	0	7	4
12	R:R:C295	R:R:G299	10.3406	1.96	No	No	0	9	4
13	R:R:D384	R:R:S387	55.6836	8.83	No	No	0	8	8
14	R:R:I389	R:R:S387	57.5502	6.19	No	No	0	9	8
15	R:R:F391	R:R:I389	73.1498	2.51	No	No	0	8	9
16	R:R:F318	R:R:F391	95.7723	13.93	Yes	No	0	9	8
17	R:R:C390	R:R:F318	63.2151	2.79	No	Yes	0	9	9
18	R:R:C390	R:R:G383	62.2445	1.96	No	No	0	9	8
19	R:R:D382	R:R:G383	57.2982	1.68	No	No	0	9	8
20	R:R:D384	R:R:V386	53.5464	5.84	No	Yes	8	8	5
21	R:R:F222	R:R:V386	51.2599	2.62	No	Yes	0	6	5
22	R:R:F222	R:R:P513	45.4783	5.78	No	No	0	6	8
23	R:R:F237	R:R:K519	11.0313	1.24	Yes	No	0	4	7
24	R:R:F237	R:R:F526	17.5408	10.72	Yes	Yes	0	4	9
25	R:R:F526	R:R:W281	13.7144	4.01	Yes	Yes	1	9	7
26	R:R:I389	R:R:W281	34.517	17.62	No	Yes	0	9	7
27	R:R:F526	R:R:M525	12.3705	2.49	Yes	Yes	1	9	5
28	R:R:M525	W:W:?1	22.7252	11.11	Yes	Yes	1	5	0
29	R:R:F391	W:W:?1	43.9104	20.1	No	Yes	0	8	0
30	R:R:I234	R:R:W281	11.1199	4.7	No	Yes	0	7	7
31	R:R:F268	R:R:L249	18.0961	6.09	Yes	No	0	8	6
32	R:R:F268	R:R:Y269	45.273	6.19	Yes	Yes	0	8	8
33	R:R:W331	R:R:Y269	46.7382	20.26	Yes	Yes	11	9	8
34	R:R:T364	R:R:W331	92.3238	18.19	No	Yes	0	9	9
35	R:R:T364	R:R:V330	92.7065	6.35	No	No	0	9	6
36	R:R:L367	R:R:V330	93.1171	2.98	Yes	No	0	5	6
37	R:R:L367	R:R:L371	95.1937	2.77	Yes	Yes	3	5	8
38	R:R:L371	R:R:Y322	97.1769	5.86	Yes	Yes	3	8	9
39	R:R:I375	R:R:Y322	99.6594	7.25	No	Yes	0	7	9
40	R:R:F318	R:R:I375	100	3.77	Yes	No	0	9	7
41	R:R:L249	R:R:N271	11.8245	4.12	No	Yes	10	6	9
42	R:R:F252	R:R:F268	28.7727	16.08	No	Yes	0	9	8
43	R:R:F252	R:R:T251	23.3038	3.89	No	No	0	9	9
44	R:R:T251	R:R:T541	16.3182	3.14	No	No	0	9	8
45	R:R:I544	R:R:T541	11.9785	3.04	No	No	0	6	8
46	R:R:I266	R:R:W331	62.8558	8.22	No	Yes	0	8	9
47	R:R:I266	R:R:P263	17.4428	1.69	No	No	0	8	9
48	R:R:P263	R:R:Y262	14.615	6.95	No	No	0	9	9
49	R:R:I266	R:R:L335	48.7961	4.28	No	No	0	8	8
50	R:R:L335	R:R:W339	47.6808	20.5	No	No	0	8	9
51	R:R:W339	R:R:W535	19.7807	8.43	No	Yes	0	9	9
52	R:R:F455	R:R:W535	12.7625	23.05	Yes	Yes	0	8	9
53	R:R:V321	R:R:W281	12.4685	3.68	No	Yes	0	8	7
54	R:R:E310	R:R:R296	10.3173	10.47	No	Yes	0	8	6
55	R:R:N521	W:W:?1	28.7541	12.95	Yes	Yes	1	8	0
56	R:R:N521	R:R:T466	25.9263	11.7	Yes	No	0	8	8
57	R:R:T466	R:R:V463	20.7	3.17	No	No	0	8	7
58	R:R:I408	R:R:V463	18.9734	1.54	No	No	0	7	7
59	R:R:I408	R:R:V329	18.6188	1.54	No	No	0	7	6
60	R:R:V329	R:R:V411	18.2781	4.81	No	No	0	6	5
61	R:R:V334	R:R:W331	18.8894	2.45	No	Yes	0	7	9
62	R:R:V333	R:R:V411	17.9701	8.02	No	No	0	9	5
63	R:R:T336	R:R:V333	17.6855	3.17	Yes	No	0	7	9
64	R:R:F360	R:R:V334	17.6948	6.55	No	No	0	9	7
65	R:R:F360	R:R:Y337	16.6402	4.13	No	Yes	0	9	7
66	R:R:F418	R:R:Y337	14.9323	6.19	Yes	Yes	4	8	7
67	R:R:F418	R:R:T336	16.5096	3.89	Yes	Yes	0	8	7
68	R:R:F343	R:R:W339	32.3052	5.01	Yes	No	0	9	9
69	R:R:F343	R:R:L426	28.3574	4.87	Yes	No	0	9	9
70	R:R:L353	R:R:Y262	10.294	2.34	No	No	0	8	9
71	R:R:P513	R:R:W480	44.1017	5.4	No	Yes	0	8	9
72	R:R:I445	R:R:L426	20.2566	2.85	No	No	0	9	9
73	R:R:I429	R:R:I445	17.5222	1.47	No	No	0	7	9
74	R:R:I429	R:R:N432	16.1129	8.5	No	No	0	7	6
75	R:R:A524	R:R:T466	11.1666	1.68	No	No	0	7	8
76	R:R:S483	R:R:W480	22.8418	2.47	No	Yes	2	7	9
77	R:R:I509	R:R:S483	21.9459	3.1	Yes	No	0	4	7
78	R:R:C490	R:R:D486	15.343	1.56	No	No	0	9	4
79	R:R:D486	R:R:I509	18.0121	1.4	No	Yes	0	4	4
80	R:R:C490	R:R:C507	13.9944	7.28	No	No	0	9	9
81	R:R:C507	R:R:V494	11.2692	3.42	No	No	0	9	5
82	R:R:L221	R:R:P513	10.0373	8.21	No	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F274	R:R:M525	2.49	0	No	Yes	9	5	2	1
R:R:I389	R:R:W281	17.62	0	No	Yes	9	7	2	2
R:R:M525	R:R:W281	6.98	1	Yes	Yes	5	7	1	2
R:R:F526	R:R:W281	4.01	1	Yes	Yes	9	7	2	2
R:R:F318	R:R:F391	13.93	0	Yes	No	9	8	2	1
R:R:F391	R:R:I389	2.51	0	No	No	8	9	1	2
R:R:F391	W:W:?1	20.1	0	No	Yes	8	0	1	0
R:R:G393	R:R:V392	3.68	1	No	No	9	9	1	2
R:R:G393	R:R:R400	3	1	No	Yes	9	9	1	1
R:R:G393	W:W:?1	4.03	1	No	Yes	9	0	1	0
R:R:R400	R:R:V404	5.23	1	Yes	No	9	7	1	2
R:R:L405	R:R:R400	4.86	1	No	Yes	8	9	2	1
R:R:H470	R:R:R400	7.9	1	No	Yes	7	9	1	1
R:R:R400	W:W:?1	9.55	1	Yes	Yes	9	0	1	0
R:R:L405	R:R:V404	2.98	1	No	No	8	7	2	2
R:R:N521	R:R:T466	11.7	1	Yes	No	8	8	1	2
R:R:C469	R:R:N521	6.3	0	No	Yes	7	8	2	1
R:R:H470	R:R:N521	2.55	1	No	Yes	7	8	1	1
R:R:H470	W:W:?1	4.04	1	No	Yes	7	0	1	0
R:R:N521	W:W:?1	12.95	1	Yes	Yes	8	0	1	0
R:R:F526	R:R:M525	2.49	1	Yes	Yes	9	5	2	1
R:R:M525	W:W:?1	11.11	1	Yes	Yes	5	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OT0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	320
Number of Links	344
Number of Hubs	35
Number of Links mediated by Hubs	133
Number of Communities	15
Number of Nodes involved in Communities	59
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	49797
Length Of Smallest Path	3
Average Path Length	15.7666
Length of Longest Path	40
Minimum Path Strength	1.275
Average Path Strength	6.5249
Maximum Path Strength	19.225
Minimum Path Correlation	0.7
Average Path Correlation	0.950841
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	55.3151
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.316
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • patched binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein kinase regulator activity • cAMP-dependent protein kinase regulator activity • protein kinase inhibitor activity • cAMP-dependent protein kinase inhibitor activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • molecular sequestering activity • protein sequestering activity • sterol binding • oxysterol binding • steroid binding • lipid binding • protein kinase A catalytic subunit binding • protein kinase A binding • kinase binding • enzyme binding • protein kinase binding • response to sterol • response to cholesterol • cellular response to sterol • cellular response to cholesterol • developmental process • cellular developmental process • cell differentiation • cell fate specification • cell fate commitment • neuroblast proliferation • multicellular organismal process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • anatomical structure development • neural precursor cell proliferation • system development • pattern specification process • digestive system development • tube development • midgut development • digestive tract development • regulation of protein stability • protein stabilization • central nervous system development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • mammary gland epithelial cell differentiation • epithelium development • mammary gland development • gland development • animal organ development • tissue development • epithelial cell differentiation • mammary gland epithelium development • epithelial-mesenchymal cell signaling • muscle cell migration • myoblast migration • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • anatomical structure morphogenesis • pancreas morphogenesis • pancreas development • animal organ morphogenesis • apoptotic process • cell death • programmed cell death • regulation of protein modification process • regulation of protein phosphorylation • negative regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • protein metabolic process • protein modification process • phosphorus metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • negative regulation of phosphorylation • cerebellum morphogenesis • cerebellar cortex morphogenesis • head development • hindbrain morphogenesis • brain development • cerebellar cortex development • cerebellum development • metencephalon development • hindbrain development • cellular localization • nucleocytoplasmic transport • nuclear transport • intracellular transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • establishment of localization in cell • protein localization to organelle • protein import into nucleus • intracellular protein transport • epidermis development • molting cycle process • hair cycle • epidermis morphogenesis • morphogenesis of an epithelium • tissue morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • hair follicle morphogenesis • positive regulation of nucleocytoplasmic transport • positive regulation of establishment of protein localization • regulation of protein localization to nucleus • positive regulation of protein transport • regulation of protein import into nucleus • positive regulation of intracellular transport • regulation of intracellular transport • positive regulation of protein localization to nucleus • positive regulation of protein import into nucleus • regulation of nucleocytoplasmic transport • positive regulation of transport • regulation of cellular localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • forebrain development • pallium development • cerebral cortex development • telencephalon development • astrocyte differentiation • cell development • astrocyte activation • glial cell development • astrocyte development • gliogenesis • response to stress • defense response • cell activation • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • brain morphogenesis • forebrain morphogenesis • neural tube development • regionalization • dorsal/ventral pattern formation • dorsal/ventral neural tube patterning • neural tube patterning • endocrine system development • type B pancreatic cell development • epithelial cell development • endocrine pancreas development • enteroendocrine cell differentiation • type B pancreatic cell differentiation • RNA metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • multicellular organism growth • developmental growth • growth • positive regulation of DNA-templated transcription • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • tube morphogenesis • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • epithelial tube morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • heart development • embryonic morphogenesis • determination of heart left/right asymmetry • circulatory system development • left/right pattern formation • regulation of somatic stem cell population maintenance • regulation of developmental process • regulation of stem cell population maintenance • stem cell population maintenance • somatic stem cell population maintenance • regulation of multicellular organismal process • maintenance of cell number • ossification • osteoblast differentiation • cell surface receptor signaling pathway • smoothened signaling pathway • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • cardiac atrium morphogenesis • cardiac chamber morphogenesis • cardiac atrium development • cardiac septum development • cardiac septum morphogenesis • cardiac chamber development • atrial septum morphogenesis • atrial septum development • mesonephric epithelium development • kidney epithelium development • branching morphogenesis of an epithelial tube • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • nephron development • regulation of morphogenesis of a branching structure • regulation of animal organ morphogenesis • positive regulation of multicellular organismal process • mesonephric tubule development • renal tubule morphogenesis • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • renal system development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • renal tubule development • regulation of morphogenesis of an epithelium • regulation of anatomical structure morphogenesis • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • morphogenesis of a branching structure • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • morphogenesis of a branching epithelium • odontogenesis of dentin-containing tooth • odontogenesis • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • ventral midline determination • ventral midline development • central nervous system neuron differentiation • neuron differentiation • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • regulation of smoothened signaling pathway • regulation of response to stimulus • positive regulation of signaling • regulation of cell differentiation • regulation of epithelial cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of epithelial cell differentiation • negative regulation of developmental process • spinal cord dorsal/ventral patterning • spinal cord development • spinal cord patterning • positive regulation of mesenchymal cell proliferation • positive regulation of cell population proliferation • regulation of mesenchymal cell proliferation • regulation of cell population proliferation • mesenchymal cell proliferation • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • diencephalon development • thalamus development • stem cell development • neural crest cell differentiation • neural crest cell development • mesenchyme development • mesenchymal cell migration • stem cell differentiation • ameboidal-type cell migration • mesenchymal cell differentiation • neural crest cell migration • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cell projection morphogenesis • neuron projection morphogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • left/right axis specification • axis specification • regulation of heart morphogenesis • blood vessel morphogenesis • vasculogenesis • vasculature development • blood vessel development • mesenchymal to epithelial transition involved in renal vesicle formation • renal vesicle morphogenesis • metanephric renal vesicle morphogenesis • renal vesicle development • metanephros development • metanephric renal vesicle formation • metanephros morphogenesis • metanephric nephron development • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • mesenchymal to epithelial transition involved in metanephros morphogenesis • epithelial cell differentiation involved in kidney development • mesenchymal to epithelial transition • metanephric nephron morphogenesis • cell differentiation involved in metanephros development • cell differentiation involved in kidney development • anatomical structure formation involved in morphogenesis • renal vesicle formation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of growth • regulation of developmental growth • positive regulation of organ growth • organ growth • positive regulation of growth • regulation of organ growth • positive regulation of developmental growth • regulation of multicellular organism growth • positive regulation of multicellular organism growth • dentate gyrus development • hippocampus development • limbic system development • smooth muscle tissue development • regulation of molecular function • regulation of DNA binding • regulation of binding • negative regulation of binding • negative regulation of molecular function • negative regulation of DNA binding • response to inositol • negative regulation of gene expression • regulation of hair cycle • regulation of hair follicle development • negative regulation of hair follicle development • negative regulation of multicellular organismal process • detection of stimulus • contact inhibition • detection of cell density • detection of biotic stimulus • response to biotic stimulus • lateral mesoderm development • determination of left/right asymmetry in lateral mesoderm • mesoderm development • dopaminergic neuron differentiation • positive regulation of nervous system development • regulation of neuroblast proliferation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • anterior/posterior pattern specification • somite development • ciliary tip • somatodendritic compartment • dendrite • dendritic tree • intracellular vesicle • cytoplasmic vesicle membrane • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • endocytic vesicle • endoplasmic reticulum-Golgi intermediate compartment • centriole • ciliary membrane • plasma membrane region • cell projection membrane • endosome • late endosome • endoplasmic reticulum
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Galpha insert domain-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Galpha insert domain-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CO1
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CO1
Name	17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL
Synonyms	24,25(S)-EPOXYCHOLESTEROL
Identifier
Formula	C27 H44 O2
Molecular Weight	400.637
SMILES
PubChem	3247059
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	9
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99835
Sequence	>6OT0_nogp_Chain_R S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D W R N S N R Y P A V I L F Y V N A C F F V G S I G W L A Q F M D G A R R E I V C R A D G T M R L G E P T S N E T L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A L G T T Y Q P L S G K T S Y F H L L T W S L P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H P G L L S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I G L P T K Q P I P D C E I K N R P S L L V E K I N L F A M F G T G I A M S T W V W T K A T L L I W R R T W C R L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	doi.org/10.1038/ncomms5355
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	doi.org/10.1038/nature18934
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	doi.org/10.1038/s41586-019-1355-4
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBJ (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.88	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBK (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol		3.24	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/β1/γ2	3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBL (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol		3.96	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	doi.org/10.1126/sciadv.abm5563
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE	Gi1/β1/γ2	3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6XBM (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	5LWE		3.14	2020-09-30	doi.org/10.1038/s41589-020-0646-2
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib	-	-	2.45	2013-04-24	doi.org/10.1038/nature12167
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	doi.org/10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	doi.org/10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	doi.org/10.1038/ncomms15383
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	doi.org/10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	ANTA XV	-	-	2.61	2014-07-23	doi.org/10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	doi.org/10.1038/ncomms5355
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	doi.org/10.1038/s41467-022-32125-2

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