psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E259	R:R:G2	3.27	No	No	0	4	4
2	R:R:F9	R:R:I5	5.02	No	No	0	4	4
3	R:R:K6	R:R:T10	6.01	No	No	0	4	5
4	R:R:K6	R:R:N260	8.39	No	No	0	4	5
5	R:R:I263	R:R:K6	11.63	No	No	0	4	4
6	R:R:F9	R:R:L264	8.53	No	No	0	4	4
7	R:R:T10	R:R:W66	3.64	No	Yes	0	5	4
8	R:R:F11	R:R:V15	7.87	No	No	0	5	5
9	R:R:L13	R:R:W66	5.69	Yes	Yes	0	4	4
10	R:R:I263	R:R:L13	4.28	No	Yes	0	4	4
11	R:R:L13	R:R:M270	4.24	Yes	No	0	4	4
12	R:R:I14	R:R:W66	5.87	No	Yes	0	4	4
13	R:R:E16	R:R:V267	7.13	No	No	0	8	4
14	R:R:A271	R:R:E16	4.53	No	No	0	6	8
15	R:R:F17	R:R:I18	3.77	Yes	No	0	5	6
16	R:R:F17	R:R:N21	12.08	Yes	No	2	5	6
17	R:R:F17	R:R:W60	9.02	Yes	No	2	5	3
18	R:R:F17	R:R:F63	38.58	Yes	No	2	5	4
19	R:R:I19	R:R:S274	6.19	No	No	0	5	7
20	R:R:N21	R:R:W60	13.56	No	No	2	6	3
21	R:R:N24	R:R:R55	6.03	No	Yes	0	9	9
22	R:R:I56	R:R:N24	5.66	No	No	0	6	9
23	R:R:N24	R:R:S277	10.43	No	No	0	9	9
24	R:R:F26	R:R:S291	5.28	No	No	0	8	5
25	R:R:F26	R:R:V294	7.87	No	No	0	8	5
26	R:R:A52	R:R:I27	3.25	No	No	0	8	9
27	R:R:I27	R:R:I281	4.42	No	No	0	9	9
28	R:R:I27	R:R:L287	4.28	No	No	0	9	9
29	R:R:I33	R:R:L29	5.71	No	No	0	4	5
30	R:R:A290	R:R:V30	5.09	No	No	0	5	8
31	R:R:D45	R:R:N31	4.04	Yes	No	3	8	8
32	R:R:N31	R:R:T49	5.85	No	No	0	8	6
33	R:R:K286	R:R:N31	5.6	Yes	No	3	8	8
34	R:R:D34	R:R:R39	8.34	No	No	0	6	6
35	R:R:D34	R:R:K286	9.68	No	Yes	0	6	8
36	R:R:V36	R:R:W35	3.68	No	No	0	5	5
37	R:R:I41	R:R:W35	3.52	No	No	0	6	5
38	R:R:K37	R:R:R39	4.95	No	No	0	6	6
39	R:R:D45	R:R:I41	7	Yes	No	0	8	6
40	R:R:I41	R:R:R46	8.77	No	No	0	6	5
41	R:R:S42	R:R:V44	3.23	No	No	0	8	6
42	R:R:D45	R:R:S42	8.83	Yes	No	0	8	8
43	R:R:F106	R:R:S43	6.61	Yes	No	0	7	6
44	R:R:F106	R:R:V44	6.55	Yes	No	0	7	6
45	R:R:V44	R:R:Y107	3.79	No	No	0	6	9
46	R:R:D45	R:R:K286	4.15	Yes	Yes	3	8	8
47	R:R:I47	R:R:L103	5.71	No	No	0	9	9
48	R:R:L103	R:R:L48	4.15	No	No	0	9	8
49	R:R:L280	R:R:L48	8.3	No	No	0	9	8
50	R:R:L51	R:R:R55	13.36	No	Yes	0	9	9
51	R:R:L51	R:R:L99	5.54	No	No	0	9	5
52	R:R:S54	R:R:S96	6.52	No	No	0	9	7
53	R:R:R55	R:R:Y272	10.29	Yes	Yes	1	9	5
54	R:R:P273	R:R:R55	7.21	No	Yes	1	8	9
55	R:R:H276	R:R:R55	12.41	Yes	Yes	1	9	9
56	R:R:I56	R:R:W60	4.7	No	No	0	6	3
57	R:R:L58	R:R:W89	6.83	No	Yes	1	4	4
58	R:R:I92	R:R:L58	5.71	No	No	0	4	4
59	R:R:L58	R:R:N93	8.24	No	Yes	1	4	8
60	R:R:M270	R:R:V59	9.13	No	No	0	4	7
61	R:R:L61	R:R:L85	4.15	No	No	0	4	2
62	R:R:L61	R:R:W89	4.56	No	Yes	0	4	4
63	R:R:I62	R:R:W89	3.52	No	Yes	1	4	4
64	R:R:I62	R:R:M270	5.83	No	No	0	4	4
65	L:L:?2	R:R:I62	4.27	Yes	No	1	0	4
66	R:R:F63	R:R:W66	6.01	No	Yes	2	4	4
67	R:R:C67	R:R:F63	5.59	Yes	No	2	4	4
68	R:R:Q266	R:R:S65	4.33	No	No	0	3	4
69	L:L:?2	R:R:S65	5.99	Yes	No	0	0	4
70	R:R:C67	R:R:W66	3.92	Yes	Yes	2	4	4
71	R:R:V70	R:R:W66	9.81	No	Yes	0	4	4
72	R:R:Q266	R:R:W66	5.48	No	Yes	0	3	4
73	R:R:C67	R:R:F71	5.59	Yes	No	0	4	4
74	R:R:F76	R:R:V68	3.93	Yes	No	0	3	3
75	R:R:F76	R:R:S69	9.25	Yes	No	0	3	4
76	R:R:A74	R:R:F72	4.16	No	No	0	2	4
77	R:R:F72	R:R:L75	8.53	No	No	0	4	2
78	R:R:L75	R:R:T78	4.42	No	No	0	2	4
79	R:R:F76	R:R:M81	6.22	Yes	No	0	3	3
80	L:L:?2	R:R:F76	6.07	Yes	Yes	0	0	3
81	R:R:M81	R:R:T78	4.52	No	No	0	3	4
82	R:R:E79	R:R:I156	9.56	No	No	0	2	3
83	L:L:?2	R:R:F82	15.79	Yes	No	0	0	2
84	R:R:I152	R:R:R83	12.53	Yes	No	4	3	3
85	R:R:N153	R:R:R83	6.03	No	No	4	3	3
86	L:L:?2	R:R:L85	5.52	Yes	No	0	0	2
87	R:R:I145	R:R:N87	4.25	No	No	0	6	4
88	R:R:N149	R:R:N87	10.9	No	No	0	4	4
89	R:R:T90	R:R:W89	6.06	Yes	Yes	1	5	4
90	R:R:N93	R:R:W89	12.43	Yes	Yes	1	8	4
91	R:R:S183	R:R:W89	4.94	No	Yes	1	7	4
92	L:L:?2	R:R:W89	31.8	Yes	Yes	1	0	4
93	R:R:N144	R:R:T90	4.39	No	Yes	1	5	5
94	R:R:I145	R:R:T90	4.56	No	Yes	0	6	5
95	R:R:I148	R:R:T90	4.56	Yes	Yes	1	4	5
96	R:R:N93	R:R:V97	4.43	Yes	No	1	8	5
97	R:R:I187	R:R:N93	7.08	No	Yes	1	5	8
98	R:R:H94	R:R:W98	10.58	No	Yes	5	5	9
99	R:R:H94	R:R:T137	4.11	No	No	5	5	8
100	R:R:H94	R:R:L141	12.86	No	No	0	5	8
101	R:R:I187	R:R:V97	4.61	No	No	1	5	5
102	R:R:P190	R:R:V97	3.53	No	No	0	9	5
103	R:R:T101	R:R:W98	7.28	No	Yes	0	8	9
104	R:R:L133	R:R:W98	5.69	No	Yes	0	7	9
105	R:R:T137	R:R:W98	20.62	No	Yes	5	8	9
106	R:R:P190	R:R:W98	24.32	No	Yes	0	9	9
107	R:R:L193	R:R:T101	4.42	No	No	0	5	8
108	R:R:L103	R:R:Y107	11.72	No	No	0	9	9
109	R:R:G104	W:W:?1	6.38	No	Yes	0	8	0
110	R:R:M197	R:R:T105	4.52	No	No	0	8	7
111	R:R:F106	R:R:K110	11.17	Yes	No	0	7	9
112	R:R:F106	R:R:V126	3.93	Yes	No	0	7	7
113	R:R:Y107	W:W:?1	13.12	No	Yes	0	9	0
114	R:R:F108	R:R:L109	3.65	Yes	No	0	8	7
115	R:R:F108	R:R:F119	7.5	Yes	Yes	0	8	9
116	R:R:F108	R:R:M197	3.73	Yes	No	0	8	8
117	R:R:F108	R:R:L200	7.31	Yes	No	0	8	7
118	R:R:L109	R:R:V129	4.47	No	No	0	7	6
119	R:R:I111	R:R:L201	5.71	No	No	0	9	9
120	R:R:A112	R:R:S204	3.42	No	Yes	0	8	9
121	R:R:F114	R:R:F119	19.29	No	Yes	0	8	9
122	R:R:F114	R:R:F203	4.29	No	No	0	8	5
123	R:R:F114	R:R:S204	3.96	No	Yes	0	8	9
124	R:R:I118	R:R:N116	12.74	No	No	0	4	8
125	R:R:F119	R:R:N116	3.62	Yes	No	0	9	8
126	R:R:F119	R:R:K123	6.2	Yes	No	0	9	9
127	R:R:L122	R:R:Y121	3.52	No	No	0	8	5
128	R:R:R125	R:R:Y121	10.29	No	No	6	8	5
129	R:R:K128	R:R:Y121	5.97	No	No	6	6	5
130	R:R:L122	R:R:V129	5.96	No	No	0	8	6
131	R:R:K128	R:R:R125	9.9	No	No	6	6	8
132	R:R:K127	R:R:L131	4.23	No	No	0	7	6
133	R:R:F142	R:R:S138	3.96	No	No	0	3	6
134	R:R:F140	R:R:F186	7.5	No	No	0	3	4
135	R:R:F186	R:R:L143	6.09	No	No	0	4	3
136	R:R:I148	R:R:N144	4.25	Yes	No	1	4	5
137	R:R:F186	R:R:N144	26.58	No	No	0	4	5
138	R:R:H151	R:R:L147	6.43	Yes	No	0	2	4
139	R:R:I148	R:R:I179	8.83	Yes	No	1	4	3
140	R:R:H151	R:R:L178	7.71	Yes	No	0	2	3
141	R:R:H151	R:R:T182	9.58	Yes	No	0	2	6
142	R:R:I152	R:R:N153	4.25	Yes	No	4	3	3
143	R:R:I156	R:R:S155	4.64	No	No	0	3	3
144	R:R:F175	R:R:S155	7.93	No	No	0	2	3
145	R:R:F172	R:R:Y159	6.19	No	No	0	3	1
146	R:R:N162	R:R:R161	3.62	No	No	0	9	2
147	R:R:E258	R:R:T173	7.06	No	No	0	4	3
148	R:R:E258	R:R:R174	6.98	No	No	0	4	2
149	L:L:?2	R:R:S176	4.49	Yes	No	0	0	4
150	R:R:V180	R:R:V251	4.81	No	Yes	0	3	3
151	L:L:?2	R:R:V180	10.4	Yes	No	0	0	3
152	R:R:F248	R:R:L181	6.09	Yes	No	7	4	2
153	R:R:L181	R:R:V251	7.45	No	Yes	0	2	3
154	R:R:L181	R:R:W252	6.83	No	No	7	2	3
155	L:L:?2	R:R:S183	4.49	Yes	No	1	0	7
156	R:R:F248	R:R:T184	6.49	Yes	No	0	4	5
157	L:L:?2	R:R:T184	10.29	Yes	No	0	0	5
158	R:R:F248	R:R:V185	3.93	Yes	No	0	4	6
159	L:L:?2	R:R:I187	11.39	Yes	No	1	0	5
160	R:R:F188	R:R:S244	9.25	No	No	0	3	5
161	R:R:I189	R:R:P190	5.08	No	No	0	6	9
162	R:R:F191	R:R:F237	8.57	No	Yes	0	7	6
163	R:R:F191	R:R:Y240	12.38	No	Yes	0	7	8
164	R:R:F237	R:R:S194	5.28	Yes	No	1	6	8
165	R:R:S194	W:W:?1	5.6	No	Yes	1	8	0
166	R:R:F237	R:R:L195	13.4	Yes	No	0	6	7
167	R:R:F198	R:R:I202	10.05	Yes	No	0	7	8
168	R:R:F198	R:R:V233	7.87	Yes	No	1	7	7
169	R:R:F198	R:R:I234	3.77	Yes	No	0	7	5
170	R:R:F198	W:W:?1	17.41	Yes	Yes	1	7	0
171	R:R:L201	W:W:?1	6.88	No	Yes	0	9	0
172	R:R:F203	R:R:W206	4.01	No	No	0	5	4
173	R:R:F203	R:R:K207	6.2	No	No	0	5	7
174	R:R:K210	R:R:W206	11.6	No	No	0	6	4
175	R:R:H208	R:R:M212	10.51	No	No	0	9	9
176	R:R:H214	R:R:T215	4.11	No	No	0	5	6
177	R:R:T215	R:R:V216	4.76	No	No	0	6	7
178	R:R:K231	R:R:R228	4.95	No	No	0	7	5
179	R:R:G229	R:R:S232	3.71	No	No	0	9	7
180	R:R:L282	R:R:S232	4.5	No	No	0	6	7
181	R:R:V233	W:W:?1	16.67	No	Yes	1	7	0
182	R:R:F236	R:R:Y240	5.16	Yes	Yes	1	9	8
183	R:R:F236	R:R:Y272	4.13	Yes	Yes	1	9	5
184	R:R:F236	R:R:H276	10.18	Yes	Yes	1	9	9
185	R:R:F236	R:R:V279	5.24	Yes	No	0	9	7
186	R:R:F237	W:W:?1	6.06	Yes	Yes	1	6	0
187	R:R:S244	R:R:Y240	3.82	No	Yes	0	5	8
188	R:R:Y240	R:R:Y272	16.88	Yes	Yes	1	8	5
189	L:L:?2	R:R:Y240	3.51	Yes	Yes	1	0	8
190	R:R:F247	R:R:V251	5.24	No	Yes	0	3	3
191	R:R:F247	R:R:L264	7.31	No	No	0	3	4
192	R:R:F247	R:R:M268	19.9	No	No	0	3	5
193	R:R:F248	R:R:W252	6.01	Yes	No	7	4	3
194	R:R:E255	R:R:E258	3.81	No	No	0	2	4
195	R:R:E259	R:R:N260	6.57	No	No	0	4	5
196	R:R:I262	R:R:Q266	6.86	No	No	0	1	3
197	L:L:?2	R:R:I262	7.12	Yes	No	0	0	1
198	L:L:?2	R:R:S265	8.98	Yes	No	0	0	4
199	L:L:?2	R:R:M268	8.46	Yes	No	0	0	5
200	L:L:?2	R:R:G269	5.12	Yes	No	0	0	4
201	R:R:P273	R:R:Y272	5.56	No	Yes	1	8	5
202	R:R:H276	R:R:Y272	15.24	Yes	Yes	1	9	5
203	R:R:C275	R:R:S274	3.44	No	No	0	4	7
204	R:R:H276	W:W:?1	13.59	Yes	Yes	1	9	0
205	R:R:L282	R:R:R288	4.86	No	No	0	6	8
206	R:R:K286	R:R:N284	4.2	Yes	No	0	8	9
207	R:R:L287	R:R:N284	9.61	No	No	0	9	9
208	R:R:V294	R:R:W297	3.68	No	No	0	5	3
209	R:R:L298	R:R:W297	5.69	No	No	0	5	3
210	R:R:V12	R:R:V267	3.21	No	No	0	6	4
211	R:R:A50	R:R:L99	3.15	No	No	0	6	5
212	R:R:A100	R:R:L51	3.15	No	No	0	8	9
213	R:R:I92	R:R:S57	3.1	No	No	0	4	3
214	R:R:I5	R:R:V4	3.07	No	No	0	4	4
215	R:R:I202	R:R:V230	3.07	No	No	0	8	7
216	R:R:M205	R:R:S204	3.07	No	Yes	0	9	9
217	R:R:I148	R:R:T86	3.04	Yes	No	1	4	3
218	R:R:I179	R:R:T86	3.04	No	No	1	3	3
219	R:R:M212	R:R:T215	3.01	No	No	0	9	6
220	R:R:K80	R:R:T78	3	No	No	0	3	4
221	R:R:L201	R:R:S204	3	No	Yes	0	9	9
222	R:R:L257	R:R:S250	3	No	No	0	1	3
223	R:R:L257	R:R:S254	3	No	No	0	1	2
224	R:R:L13	R:R:V267	2.98	Yes	No	0	4	4
225	R:R:L287	R:R:V30	2.98	No	No	0	9	8
226	R:R:I88	R:R:M84	2.92	No	No	0	3	3
227	R:R:I33	R:R:K37	2.91	No	No	0	4	6
228	R:R:I18	R:R:L22	2.85	No	No	0	6	4
229	R:R:I88	R:R:L61	2.85	No	No	0	3	4
230	R:R:I249	R:R:L245	2.85	No	No	0	4	4
231	R:R:I152	R:R:N149	2.83	Yes	No	0	3	4
232	R:R:C275	R:R:F236	2.79	No	Yes	0	4	9
233	R:R:L143	R:R:L147	2.77	No	No	0	3	4
234	R:R:A241	R:R:F191	2.77	No	No	0	6	7
235	R:R:L195	R:R:L199	2.77	No	No	0	7	4
236	R:R:K285	R:R:Q289	2.71	No	No	0	6	7
237	R:R:R55	R:R:S96	2.64	Yes	No	0	9	7
238	R:R:F26	R:R:V30	2.62	No	No	0	8	8
239	R:R:F95	R:R:V91	2.62	No	No	0	6	6
240	R:R:H227	R:R:K231	2.62	No	No	0	9	7
241	R:R:F243	R:R:I242	2.51	No	No	0	7	5
242	R:R:F95	R:R:L141	2.44	No	No	0	6	8
243	R:R:L296	R:R:R299	2.43	No	No	0	3	7
244	R:R:L120	R:R:W124	2.28	No	No	0	7	4
245	R:R:H227	R:R:R209	2.26	No	No	0	9	6
246	R:R:G283	W:W:?1	2.13	No	Yes	0	7	0
247	R:R:G2	R:R:G3	2.11	No	No	0	4	4
248	R:R:G229	R:R:G283	2.11	No	No	0	9	7
249	R:R:C67	R:R:G64	1.96	Yes	No	0	4	3
250	R:R:G20	R:R:S274	1.86	No	No	0	9	7
251	R:R:G23	R:R:S277	1.86	No	No	0	7	9
252	R:R:G102	R:R:V130	1.84	No	No	0	5	7
253	R:R:G102	R:R:T105	1.82	No	No	0	5	7
254	R:R:G158	R:R:N157	1.7	No	No	0	2	1
255	R:R:C278	R:R:I19	1.64	No	No	0	5	5
256	R:R:S7	R:R:V4	1.62	No	No	0	3	4
257	R:R:S177	R:R:V251	1.62	No	Yes	0	3	3
258	R:R:V136	R:R:V139	1.6	No	No	0	6	4
259	R:R:I8	R:R:S7	1.55	No	No	0	6	3
260	R:R:I152	R:R:S155	1.55	Yes	No	0	3	3
261	R:R:I19	R:R:V15	1.54	No	No	0	5	5
262	R:R:K40	R:R:S42	1.53	No	No	0	6	8
263	R:R:K128	R:R:V132	1.52	No	No	0	6	3
264	R:R:I249	R:R:T253	1.52	No	No	0	4	4
265	R:R:G158	R:R:R161	1.5	No	No	0	2	2
266	R:R:L261	R:R:S176	1.5	No	No	0	1	4
267	R:R:L261	R:R:S177	1.5	No	No	0	1	3
268	R:R:G229	R:R:R228	1.5	No	No	0	9	5
269	R:R:L261	R:R:S265	1.5	No	No	0	1	4
270	R:R:L295	R:R:S291	1.5	No	No	0	7	5
271	R:R:N113	R:R:S204	1.49	No	Yes	0	8	9
272	R:R:L133	R:R:V136	1.49	No	No	0	7	6
273	R:R:L239	R:R:T235	1.47	No	No	0	7	7
274	R:R:A226	R:R:H227	1.46	No	No	0	8	9
275	R:R:F72	R:R:P73	1.44	No	No	0	4	4
276	R:R:I242	R:R:L238	1.43	No	No	0	5	5
277	R:R:I242	R:R:L239	1.43	No	No	0	5	7
278	R:R:I156	R:R:N157	1.42	No	No	0	3	1
279	R:R:L134	R:R:L99	1.38	No	No	0	8	5
280	R:R:L257	R:R:L264	1.38	No	No	0	1	4
281	R:R:K217	R:R:Q213	1.36	No	No	0	5	6
282	R:R:H151	R:R:I150	1.33	Yes	No	0	2	3
283	R:R:H208	R:R:K211	1.31	No	No	0	9	5
284	R:R:F248	R:R:I249	1.26	Yes	No	0	4	4
285	R:R:F119	R:R:L120	1.22	Yes	No	0	9	7
286	R:R:F142	R:R:L141	1.22	No	No	0	3	8
287	R:R:F172	R:R:F175	1.07	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L13	4.2975	4	0	4
2	R:R:F17	15.8625	4	2	5
3	R:R:D45	6.005	4	3	8
4	R:R:R55	8.65667	6	1	9
5	R:R:W66	5.77429	7	2	4
6	R:R:C67	4.265	4	2	4
7	R:R:F76	6.3675	4	0	3
8	R:R:W89	10.02	7	1	4
9	R:R:T90	4.8925	4	1	5
10	R:R:N93	8.045	4	1	8
11	R:R:W98	13.698	5	5	9
12	R:R:F106	7.065	4	0	7
13	R:R:F108	5.5475	4	0	8
14	R:R:F119	7.566	5	0	9
15	R:R:I148	5.17	4	1	4
16	R:R:H151	6.2625	4	0	2
17	R:R:I152	5.29	4	4	3
18	R:R:F198	9.775	4	1	7
19	R:R:S204	2.988	5	0	9
20	R:R:F236	5.5	5	1	9
21	R:R:F237	8.3275	4	1	6
22	R:R:Y240	8.35	5	1	8
23	R:R:F248	4.756	5	7	4
24	R:R:V251	4.78	4	0	3
25	R:R:Y272	10.42	5	1	5
26	R:R:H276	12.855	4	1	9
27	R:R:K286	5.9075	4	3	8
28	W:W:?1	9.76	9	1	0
29	L:L:?2	8.98063	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K6	R:R:N260	10.9826	8.39	No	No	0	4	5
2	R:R:T10	R:R:W66	10.7906	3.64	No	Yes	0	5	4
3	R:R:Q266	R:R:W66	24.692	5.48	No	Yes	0	3	4
4	R:R:Q266	R:R:S65	13.216	4.33	No	No	0	3	4
5	L:L:?2	R:R:S65	14.0083	5.99	Yes	No	0	0	4
6	L:L:?2	R:R:M268	11.1673	8.46	Yes	No	0	0	5
7	R:R:F247	R:R:M268	10.2389	19.9	No	No	0	3	5
8	R:R:I262	R:R:Q266	13.216	6.86	No	No	0	1	3
9	L:L:?2	R:R:I262	14.0083	7.12	Yes	No	0	0	1
10	R:R:L13	R:R:M270	12.0446	4.24	Yes	No	0	4	4
11	R:R:I62	R:R:M270	13.8917	5.83	No	No	0	4	4
12	L:L:?2	R:R:I62	11.7165	4.27	Yes	No	1	0	4
13	L:L:?2	R:R:Y240	100	3.51	Yes	Yes	1	0	8
14	R:R:F236	R:R:Y240	33.7449	5.16	Yes	Yes	1	9	8
15	R:R:Y240	R:R:Y272	35.293	16.88	Yes	Yes	1	8	5
16	R:R:F191	R:R:Y240	32.4641	12.38	No	Yes	0	7	8
17	R:R:F191	R:R:F237	32.0023	8.57	No	Yes	0	7	6
18	R:R:F237	W:W:?1	31.2927	6.06	Yes	Yes	1	6	0
19	R:R:Y107	W:W:?1	48.1445	13.12	No	Yes	0	9	0
20	R:R:V44	R:R:Y107	42.1197	3.79	No	No	0	6	9
21	R:R:S42	R:R:V44	36.2189	3.23	No	No	0	8	6
22	R:R:D45	R:R:S42	33.7303	8.83	Yes	No	0	8	8
23	R:R:D45	R:R:K286	24.7722	4.15	Yes	Yes	3	8	8
24	R:R:K286	R:R:N284	17.2066	4.2	Yes	No	0	8	9
25	R:R:L287	R:R:N284	15.8918	9.61	No	No	0	9	9
26	R:R:L287	R:R:V30	10.5889	2.98	No	No	0	9	8
27	R:R:F236	R:R:H276	32.7168	10.18	Yes	Yes	1	9	9
28	R:R:H276	W:W:?1	67.322	13.59	Yes	Yes	1	9	0
29	R:R:H276	R:R:Y272	30.7993	15.24	Yes	Yes	1	9	5
30	L:L:?2	R:R:F76	10.5062	6.07	Yes	Yes	0	0	3
31	R:R:T90	R:R:W89	29.4578	6.06	Yes	Yes	1	5	4
32	R:R:I145	R:R:T90	16.757	4.56	No	Yes	0	6	5
33	R:R:I145	R:R:N87	15.746	4.25	No	No	0	6	4
34	R:R:N149	R:R:N87	14.7301	10.9	No	No	0	4	4
35	R:R:I152	R:R:N149	13.7094	2.83	Yes	No	0	3	4
36	R:R:I152	R:R:S155	10.618	1.55	Yes	No	0	3	3
37	L:L:?2	R:R:I187	16.9563	11.39	Yes	No	1	0	5
38	R:R:I187	R:R:V97	15.1238	4.61	No	No	1	5	5
39	R:R:P190	R:R:V97	16.1105	3.53	No	No	0	9	5
40	R:R:P190	R:R:W98	14.0253	24.32	No	Yes	0	9	9
41	R:R:L201	W:W:?1	38.6833	6.88	No	Yes	0	9	0
42	R:R:L201	R:R:S204	36.2141	3	No	Yes	0	9	9
43	R:R:F114	R:R:S204	31.3389	3.96	No	Yes	0	8	9
44	R:R:F114	R:R:F119	25.11	19.29	No	Yes	0	8	9
45	R:R:F108	R:R:F119	17.3184	7.5	Yes	Yes	0	8	9
46	R:R:G283	W:W:?1	13.3691	2.13	No	Yes	0	7	0
47	R:R:G229	R:R:G283	12.0519	2.11	No	No	0	9	7
48	L:L:?2	R:R:W89	32.5103	31.8	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L58	R:R:W89	6.83	1	No	Yes	4	4	2	1
R:R:L58	R:R:N93	8.24	1	No	Yes	4	8	2	2
R:R:L61	R:R:L85	4.15	0	No	No	4	2	2	1
R:R:L61	R:R:W89	4.56	0	No	Yes	4	4	2	1
R:R:I62	R:R:W89	3.52	1	No	Yes	4	4	1	1
R:R:I62	R:R:M270	5.83	1	No	No	4	4	1	2
L:L:?2	R:R:I62	4.27	1	Yes	No	0	4	0	1
R:R:Q266	R:R:S65	4.33	0	No	No	3	4	2	1
L:L:?2	R:R:S65	5.99	1	Yes	No	0	4	0	1
R:R:F76	R:R:V68	3.93	0	Yes	No	3	3	1	2
R:R:F76	R:R:S69	9.25	0	Yes	No	3	4	1	2
R:R:F76	R:R:M81	6.22	0	Yes	No	3	3	1	2
L:L:?2	R:R:F76	6.07	1	Yes	Yes	0	3	0	1
L:L:?2	R:R:F82	15.79	1	Yes	No	0	2	0	1
L:L:?2	R:R:L85	5.52	1	Yes	No	0	2	0	1
R:R:T90	R:R:W89	6.06	1	Yes	Yes	5	4	2	1
R:R:N93	R:R:W89	12.43	1	Yes	Yes	8	4	2	1
R:R:S183	R:R:W89	4.94	1	No	Yes	7	4	1	1
L:L:?2	R:R:W89	31.8	1	Yes	Yes	0	4	0	1
R:R:N93	R:R:V97	4.43	1	Yes	No	8	5	2	2
R:R:I187	R:R:N93	7.08	1	No	Yes	5	8	1	2
R:R:I187	R:R:V97	4.61	1	No	No	5	5	1	2
L:L:?2	R:R:S176	4.49	1	Yes	No	0	4	0	1
R:R:V180	R:R:V251	4.81	0	No	Yes	3	3	1	2
L:L:?2	R:R:V180	10.4	1	Yes	No	0	3	0	1
L:L:?2	R:R:S183	4.49	1	Yes	No	0	7	0	1
R:R:F248	R:R:T184	6.49	7	Yes	No	4	5	2	1
L:L:?2	R:R:T184	10.29	1	Yes	No	0	5	0	1
L:L:?2	R:R:I187	11.39	1	Yes	No	0	5	0	1
R:R:F191	R:R:Y240	12.38	0	No	Yes	7	8	2	1
R:R:F236	R:R:Y240	5.16	1	Yes	Yes	9	8	2	1
R:R:F236	R:R:Y272	4.13	1	Yes	Yes	9	5	2	2
R:R:S244	R:R:Y240	3.82	0	No	Yes	5	8	2	1
R:R:Y240	R:R:Y272	16.88	1	Yes	Yes	8	5	1	2
L:L:?2	R:R:Y240	3.51	1	Yes	Yes	0	8	0	1
R:R:F247	R:R:V251	5.24	0	No	Yes	3	3	2	2
R:R:F247	R:R:M268	19.9	0	No	No	3	5	2	1
R:R:I262	R:R:Q266	6.86	0	No	No	1	3	1	2
L:L:?2	R:R:I262	7.12	1	Yes	No	0	1	0	1
L:L:?2	R:R:S265	8.98	1	Yes	No	0	4	0	1
L:L:?2	R:R:M268	8.46	1	Yes	No	0	5	0	1
L:L:?2	R:R:G269	5.12	1	Yes	No	0	4	0	1
R:R:L261	R:R:S176	1.5	0	No	No	1	4	2	1
R:R:L261	R:R:S265	1.5	0	No	No	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V44	R:R:Y107	3.79	0	No	No	6	9	2	1
R:R:R55	R:R:Y272	10.29	1	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	12.41	1	Yes	Yes	9	9	1	2
R:R:L103	R:R:Y107	11.72	0	No	No	9	9	2	1
R:R:G104	W:W:?1	6.38	0	No	Yes	8	0	1	0
R:R:Y107	W:W:?1	13.12	0	No	Yes	9	0	1	0
R:R:I111	R:R:L201	5.71	0	No	No	9	9	2	1
R:R:F191	R:R:F237	8.57	0	No	Yes	7	6	2	1
R:R:F237	R:R:S194	5.28	1	Yes	No	6	8	1	1
R:R:S194	W:W:?1	5.6	1	No	Yes	8	0	1	0
R:R:F237	R:R:L195	13.4	1	Yes	No	6	7	1	2
R:R:F198	R:R:I202	10.05	1	Yes	No	7	8	1	2
R:R:F198	R:R:V233	7.87	1	Yes	No	7	7	1	1
R:R:F198	R:R:I234	3.77	1	Yes	No	7	5	1	2
R:R:F198	W:W:?1	17.41	1	Yes	Yes	7	0	1	0
R:R:L201	W:W:?1	6.88	0	No	Yes	9	0	1	0
R:R:V233	W:W:?1	16.67	1	No	Yes	7	0	1	0
R:R:F236	R:R:Y272	4.13	1	Yes	Yes	9	5	2	2
R:R:F236	R:R:H276	10.18	1	Yes	Yes	9	9	2	1
R:R:F237	W:W:?1	6.06	1	Yes	Yes	6	0	1	0
R:R:H276	R:R:Y272	15.24	1	Yes	Yes	9	5	1	2
R:R:H276	W:W:?1	13.59	1	Yes	Yes	9	0	1	0
R:R:L201	R:R:S204	3	0	No	Yes	9	9	1	2
R:R:G283	W:W:?1	2.13	0	No	Yes	7	0	1	0
R:R:G229	R:R:G283	2.11	0	No	No	9	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XQO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	265
Number of Links	287
Number of Hubs	29
Number of Links mediated by Hubs	128
Number of Communities	7
Number of Nodes involved in Communities	45
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	49
Number Of Links MetaPath	48
Number of Shortest Paths	60662
Length Of Smallest Path	3
Average Path Length	12.8041
Length of Longest Path	29
Minimum Path Strength	1.39
Average Path Strength	7.7598
Maximum Path Strength	25.33
Minimum Path Correlation	0.7
Average Path Correlation	0.924599
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	46.0384
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.7382
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • metal ion binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • exo-alpha-sialidase activity • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • bitter taste receptor activity • G protein-coupled receptor activity • carbohydrate metabolic process • catabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • primary metabolic process • metabolic process • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GOQ
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	GOQ
Name	8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid
Synonyms
Identifier
Formula	C17 H11 N O7
Molecular Weight	341.272
SMILES
PubChem	2236
Formal Charge	0
Total Atoms	36
Total Chiral Atoms	0
Total Bonds	39
Total Aromatic Bonds	16


Code	CLR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8XQO_nogp_Chain_R G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G Y R R N F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V K A H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	10.1038/s41467-024-54157-6
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol	Gi1/β1/γ1	2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol		2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	10.1038/s41586-024-07569-9

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