psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F9	R:R:I5	5.02	Yes	Yes	0	4	4
2	R:R:I5	R:R:R256	10.02	Yes	No	0	4	1
3	R:R:I5	R:R:N260	7.08	Yes	No	0	4	5
4	R:R:F9	R:R:I263	5.02	Yes	No	0	4	4
5	R:R:F9	R:R:L264	7.31	Yes	No	0	4	4
6	R:R:T10	R:R:W66	3.64	No	Yes	0	5	4
7	R:R:F11	R:R:V15	5.24	No	No	0	5	5
8	R:R:E16	R:R:V12	4.28	Yes	No	0	8	6
9	R:R:L13	R:R:W66	5.69	No	Yes	2	4	4
10	R:R:L13	R:R:Q266	3.99	No	Yes	2	4	3
11	R:R:L13	R:R:M270	4.24	No	Yes	0	4	4
12	R:R:E16	R:R:M270	4.06	Yes	Yes	0	8	4
13	R:R:A271	R:R:E16	4.53	No	Yes	0	6	8
14	R:R:E16	R:R:S274	4.31	Yes	No	0	8	7
15	R:R:F17	R:R:I18	3.77	Yes	No	0	5	6
16	R:R:F17	R:R:N21	14.5	Yes	No	4	5	6
17	R:R:F17	R:R:W60	10.02	Yes	No	4	5	3
18	R:R:F17	R:R:F63	40.73	Yes	No	0	5	4
19	R:R:F17	R:R:M270	3.73	Yes	Yes	0	5	4
20	R:R:I19	R:R:S274	6.19	No	No	0	5	7
21	R:R:N21	R:R:W60	11.3	No	No	4	6	3
22	R:R:N24	R:R:R55	9.64	No	Yes	0	9	9
23	R:R:I56	R:R:N24	5.66	No	No	0	6	9
24	R:R:N24	R:R:S277	5.96	No	No	0	9	9
25	R:R:F26	R:R:V30	7.87	No	No	0	8	8
26	R:R:F26	R:R:I281	3.77	No	No	0	8	9
27	R:R:A290	R:R:F26	4.16	No	No	0	5	8
28	R:R:A52	R:R:I27	4.87	No	No	0	8	9
29	R:R:I27	R:R:L287	7.14	No	No	0	9	9
30	R:R:D45	R:R:N31	6.73	No	No	0	8	8
31	R:R:N31	R:R:T49	10.24	No	No	0	8	6
32	R:R:C32	R:R:W35	3.92	No	No	0	4	5
33	R:R:D34	R:R:R39	5.96	No	No	0	6	6
34	R:R:D34	R:R:K286	8.3	No	No	0	6	8
35	R:R:V36	R:R:W35	4.9	No	No	0	5	5
36	R:R:K37	R:R:R39	4.95	No	No	0	6	6
37	R:R:D45	R:R:I41	5.6	No	No	0	8	6
38	R:R:I41	R:R:R46	3.76	No	No	0	6	5
39	R:R:S42	R:R:V44	4.85	No	No	0	8	6
40	R:R:D45	R:R:S42	8.83	No	No	0	8	8
41	R:R:F106	R:R:S43	5.28	Yes	No	0	7	6
42	R:R:F106	R:R:V44	5.24	Yes	No	0	7	6
43	R:R:V44	R:R:Y107	3.79	No	No	0	6	9
44	R:R:I47	R:R:L103	5.71	No	No	0	9	9
45	R:R:L280	R:R:L48	4.15	No	No	0	9	8
46	R:R:L48	R:R:N284	5.49	No	No	0	8	9
47	R:R:L51	R:R:R55	15.79	No	Yes	0	9	9
48	R:R:R55	R:R:Y272	7.2	Yes	Yes	1	9	5
49	R:R:P273	R:R:R55	7.21	No	Yes	0	8	9
50	R:R:H276	R:R:R55	12.41	Yes	Yes	1	9	9
51	R:R:I56	R:R:W60	4.7	No	No	0	6	3
52	R:R:I92	R:R:S57	4.64	No	No	0	4	3
53	R:R:I62	R:R:L58	4.28	No	Yes	0	4	4
54	R:R:L58	R:R:W89	4.56	Yes	Yes	3	4	4
55	R:R:L58	R:R:N93	4.12	Yes	Yes	3	4	8
56	R:R:M270	R:R:V59	4.56	Yes	No	0	4	7
57	R:R:L61	R:R:L85	4.15	No	No	0	4	2
58	R:R:I62	R:R:M270	10.2	No	Yes	0	4	4
59	R:R:F63	R:R:W66	5.01	No	Yes	0	4	4
60	R:R:L85	R:R:S65	4.5	No	No	0	2	4
61	R:R:V70	R:R:W66	15.94	No	Yes	2	4	4
62	R:R:F71	R:R:W66	6.01	No	Yes	2	4	4
63	R:R:Q266	R:R:W66	4.38	Yes	Yes	2	3	4
64	R:R:C67	R:R:F71	8.38	No	No	0	4	4
65	R:R:L75	R:R:V68	5.96	No	No	0	2	3
66	R:R:F76	R:R:V68	5.24	Yes	No	0	3	3
67	R:R:F76	R:R:S69	5.28	Yes	No	0	3	4
68	R:R:F71	R:R:V70	7.87	No	No	2	4	4
69	R:R:A74	R:R:F72	4.16	No	No	0	2	4
70	R:R:F72	R:R:L75	3.65	No	No	0	4	2
71	R:R:L75	R:R:M81	8.48	No	No	0	2	3
72	R:R:F76	R:R:M81	3.73	Yes	No	0	3	3
73	R:R:E79	R:R:K80	5.4	No	No	0	2	3
74	R:R:K80	R:R:R83	4.95	No	Yes	0	3	3
75	R:R:F172	R:R:F82	4.29	No	No	0	3	2
76	R:R:N87	R:R:R83	4.82	No	Yes	0	4	3
77	R:R:I152	R:R:R83	12.53	No	Yes	0	3	3
78	R:R:N153	R:R:R83	4.82	No	Yes	0	3	3
79	R:R:T90	R:R:W89	3.64	No	Yes	0	5	4
80	R:R:N93	R:R:W89	16.95	Yes	Yes	3	8	4
81	R:R:S183	R:R:W89	3.71	No	Yes	0	7	4
82	R:R:N144	R:R:T90	7.31	No	No	0	5	5
83	R:R:N93	R:R:V97	4.43	Yes	No	3	8	5
84	R:R:I187	R:R:N93	8.5	No	Yes	3	5	8
85	R:R:H94	R:R:W98	10.58	Yes	Yes	6	5	9
86	R:R:H94	R:R:T137	4.11	Yes	Yes	6	5	8
87	R:R:H94	R:R:L141	14.14	Yes	No	0	5	8
88	R:R:F186	R:R:H94	9.05	No	Yes	0	4	5
89	R:R:I187	R:R:V97	6.14	No	No	3	5	5
90	R:R:T101	R:R:W98	9.7	No	Yes	0	8	9
91	R:R:L133	R:R:W98	7.97	No	Yes	0	7	9
92	R:R:T137	R:R:W98	24.26	Yes	Yes	6	8	9
93	R:R:P190	R:R:W98	16.21	No	Yes	0	9	9
94	R:R:L103	R:R:Y107	12.89	No	No	0	9	9
95	R:R:L103	R:R:L280	4.15	No	No	0	9	9
96	R:R:G104	W:W:?1	8.28	No	Yes	0	8	0
97	R:R:M197	R:R:T105	6.02	No	No	0	8	7
98	R:R:F106	R:R:K110	8.69	Yes	No	5	7	9
99	R:R:F106	R:R:V126	3.93	Yes	No	5	7	7
100	R:R:Y107	W:W:?1	13.25	No	Yes	0	9	0
101	R:R:F108	R:R:L109	4.87	Yes	No	0	8	7
102	R:R:A112	R:R:F108	4.16	No	Yes	0	8	8
103	R:R:F108	R:R:M197	9.95	Yes	No	0	8	8
104	R:R:F108	R:R:L200	6.09	Yes	No	0	8	7
105	R:R:L109	R:R:V126	4.47	No	No	0	7	7
106	R:R:K110	R:R:V126	6.07	No	No	5	9	7
107	R:R:F114	R:R:F119	9.65	No	No	0	8	9
108	R:R:F114	R:R:F203	4.29	No	No	0	8	5
109	R:R:F114	R:R:S204	5.28	No	No	0	8	9
110	R:R:I118	R:R:N116	5.66	No	No	0	4	8
111	R:R:F119	R:R:K123	7.44	No	No	0	9	9
112	R:R:R125	R:R:Y121	7.2	No	No	0	8	5
113	R:R:L122	R:R:V129	7.45	No	No	0	8	6
114	R:R:K128	R:R:R125	3.71	No	No	0	6	8
115	R:R:K127	R:R:L131	5.64	No	No	0	7	6
116	R:R:F140	R:R:T137	3.89	No	Yes	0	3	8
117	R:R:F140	R:R:F186	4.29	No	No	0	3	4
118	R:R:L143	R:R:L147	5.54	No	No	0	3	4
119	R:R:I148	R:R:N144	4.25	No	No	0	4	5
120	R:R:F186	R:R:N144	26.58	No	No	0	4	5
121	R:R:I145	R:R:N149	4.25	No	No	0	6	4
122	R:R:H151	R:R:L147	7.71	Yes	No	0	2	4
123	R:R:I148	R:R:I179	4.42	No	No	0	4	3
124	R:R:H151	R:R:L178	6.43	Yes	No	0	2	3
125	R:R:H151	R:R:T182	8.21	Yes	No	0	2	6
126	R:R:F175	R:R:I152	3.77	Yes	No	0	2	3
127	R:R:F175	R:R:S155	17.18	Yes	No	0	2	3
128	R:R:F172	R:R:F175	4.29	No	Yes	0	3	2
129	R:R:F172	R:R:S176	3.96	No	No	0	3	4
130	R:R:E258	R:R:T173	8.47	No	No	0	4	3
131	R:R:F175	R:R:I179	5.02	Yes	No	0	2	3
132	R:R:L257	R:R:S177	4.5	No	No	0	1	3
133	R:R:F248	R:R:L181	6.09	Yes	No	7	4	2
134	R:R:L181	R:R:V251	7.45	No	Yes	0	2	3
135	R:R:L181	R:R:W252	7.97	No	No	7	2	3
136	R:R:F247	R:R:T184	9.08	Yes	No	0	3	5
137	R:R:F248	R:R:T184	7.78	Yes	No	0	4	5
138	R:R:F248	R:R:V185	3.93	Yes	No	0	4	6
139	R:R:F188	R:R:S244	7.93	No	No	0	3	5
140	R:R:F188	R:R:L245	3.65	No	No	0	3	4
141	R:R:F191	R:R:Y240	12.38	No	Yes	0	7	8
142	R:R:S194	W:W:?1	8.48	No	Yes	0	8	0
143	R:R:L195	R:R:L199	6.92	No	No	0	7	4
144	R:R:F237	R:R:L195	3.65	No	No	0	6	7
145	R:R:F198	R:R:L199	3.65	Yes	No	0	7	4
146	R:R:F198	R:R:I202	6.28	Yes	No	0	7	8
147	R:R:F198	R:R:V233	5.24	Yes	No	0	7	7
148	R:R:F198	R:R:I234	3.77	Yes	No	0	7	5
149	R:R:F198	R:R:F237	13.93	Yes	No	1	7	6
150	R:R:F198	W:W:?1	11.8	Yes	Yes	1	7	0
151	R:R:L201	W:W:?1	6.7	No	Yes	0	9	0
152	R:R:F203	R:R:K207	8.69	No	No	0	5	7
153	R:R:K210	R:R:W206	22.05	No	No	0	6	4
154	R:R:H208	R:R:M212	9.19	No	No	0	9	9
155	R:R:K210	R:R:R209	7.43	No	No	0	6	6
156	R:R:M212	R:R:T215	4.52	No	No	0	9	6
157	R:R:F236	R:R:Y240	11.35	Yes	Yes	1	9	8
158	R:R:F236	R:R:Y272	4.13	Yes	Yes	1	9	5
159	R:R:C275	R:R:F236	4.19	No	Yes	0	4	9
160	R:R:F236	R:R:V279	6.55	Yes	No	0	9	7
161	R:R:F237	W:W:?1	4.92	No	Yes	1	6	0
162	R:R:F243	R:R:L239	8.53	No	No	0	7	7
163	R:R:S244	R:R:Y240	5.09	No	Yes	0	5	8
164	R:R:Y240	R:R:Y272	12.91	Yes	Yes	1	8	5
165	R:R:F243	R:R:I242	6.28	No	No	0	7	5
166	R:R:F247	R:R:V251	3.93	Yes	Yes	0	3	3
167	R:R:F247	R:R:L264	7.31	Yes	No	0	3	4
168	R:R:F247	R:R:M268	17.42	Yes	No	0	3	5
169	R:R:F248	R:R:W252	7.02	Yes	No	7	4	3
170	R:R:S250	R:R:S254	6.52	No	No	0	3	2
171	R:R:L257	R:R:L261	9.69	No	No	0	1	1
172	R:R:E258	R:R:E259	20.3	No	No	0	4	4
173	R:R:I262	R:R:Q266	5.49	No	Yes	0	1	3
174	R:R:I263	R:R:Q266	4.12	No	Yes	0	4	3
175	R:R:H276	R:R:Y272	25.04	Yes	Yes	1	9	5
176	R:R:H276	R:R:L280	10.29	Yes	No	0	9	9
177	R:R:H276	W:W:?1	7.26	Yes	Yes	1	9	0
178	R:R:I281	R:R:L287	5.71	No	No	0	9	9
179	R:R:K286	R:R:N284	4.2	No	No	0	8	9
180	R:R:L287	R:R:N284	12.36	No	No	0	9	9
181	R:R:K285	R:R:R288	3.71	No	No	0	6	8
182	R:R:I41	R:R:W35	3.52	No	No	0	6	5
183	R:R:L122	R:R:Y121	3.52	No	No	0	8	5
184	R:R:G269	R:R:M268	3.49	No	No	0	4	5
185	R:R:K207	R:R:W206	3.48	No	No	0	7	4
186	R:R:L61	R:R:W89	3.42	No	Yes	0	4	4
187	R:R:A112	R:R:S204	3.42	No	No	0	8	9
188	R:R:I189	R:R:P190	3.39	No	No	0	6	9
189	R:R:S54	R:R:S96	3.26	No	No	0	9	7
190	R:R:S96	R:R:V97	3.23	No	No	0	7	5
191	R:R:S177	R:R:V251	3.23	No	Yes	0	3	3
192	R:R:V12	R:R:V267	3.21	No	No	0	6	4
193	R:R:V180	R:R:V251	3.21	No	Yes	0	3	3
194	R:R:T105	R:R:V129	3.17	No	No	0	7	6
195	R:R:A100	R:R:L51	3.15	No	No	0	8	9
196	R:R:I156	R:R:S155	3.1	No	No	0	3	3
197	R:R:I19	R:R:V15	3.07	No	No	0	5	5
198	R:R:I202	R:R:V230	3.07	No	No	0	8	7
199	R:R:I234	R:R:V230	3.07	No	No	0	5	7
200	R:R:K6	R:R:T10	3	No	No	0	4	5
201	R:R:L282	R:R:S232	3	No	No	0	6	7
202	R:R:L239	R:R:T235	2.95	No	No	0	7	7
203	R:R:I92	R:R:L58	2.85	No	Yes	0	4	4
204	R:R:I111	R:R:L201	2.85	No	No	0	9	9
205	R:R:I145	R:R:N87	2.83	No	No	0	6	4
206	R:R:I152	R:R:N149	2.83	No	No	0	3	4
207	R:R:L134	R:R:L99	2.77	No	No	0	8	5
208	R:R:G283	W:W:?1	2.76	No	Yes	0	7	0
209	R:R:E259	R:R:K6	2.7	No	No	0	4	4
210	R:R:F76	R:R:S65	2.64	Yes	No	0	3	4
211	R:R:F247	R:R:S265	2.64	Yes	No	0	3	4
212	R:R:F188	R:R:T192	2.59	No	No	0	3	4
213	R:R:F63	R:R:I14	2.51	No	No	0	4	4
214	R:R:T253	R:R:W252	2.43	No	No	0	4	3
215	R:R:L282	R:R:R288	2.43	No	No	0	6	8
216	R:R:L298	R:R:R299	2.43	No	No	0	5	7
217	R:R:F119	R:R:N116	2.42	No	No	0	9	8
218	R:R:K123	R:R:W124	2.32	No	No	0	9	4
219	R:R:L193	R:R:W98	2.28	No	Yes	0	5	9
220	R:R:F175	R:R:H151	2.26	Yes	Yes	0	2	2
221	R:R:G2	R:R:G3	2.11	No	No	0	4	4
222	R:R:C67	R:R:G64	1.96	No	No	0	4	3
223	R:R:G20	R:R:S274	1.86	No	No	0	9	7
224	R:R:G23	R:R:S277	1.86	No	No	0	7	9
225	R:R:G102	R:R:V130	1.84	No	No	0	5	7
226	R:R:G102	R:R:T105	1.82	No	No	0	5	7
227	R:R:G2	R:R:I5	1.76	No	Yes	0	4	4
228	R:R:G23	R:R:L22	1.71	No	No	0	7	4
229	R:R:G158	R:R:N157	1.7	No	No	0	2	1
230	R:R:A28	R:R:I53	1.62	No	No	0	7	6
231	R:R:T137	R:R:V136	1.59	Yes	No	0	8	6
232	R:R:A50	R:R:L99	1.58	No	No	0	6	5
233	R:R:T86	R:R:T90	1.57	No	No	0	3	5
234	R:R:I8	R:R:S7	1.55	No	No	0	6	3
235	R:R:I56	R:R:S25	1.55	No	No	0	6	5
236	R:R:I281	R:R:S291	1.55	No	No	0	9	5
237	R:R:K40	R:R:S42	1.53	No	No	0	6	8
238	R:R:M205	R:R:S204	1.53	No	No	0	9	9
239	R:R:I53	R:R:T49	1.52	No	No	0	6	6
240	R:R:K128	R:R:V132	1.52	No	No	0	6	3
241	R:R:I249	R:R:T253	1.52	No	No	0	4	4
242	R:R:M81	R:R:T78	1.51	No	No	0	3	4
243	R:R:G229	R:R:R228	1.5	No	No	0	9	5
244	R:R:L141	R:R:V91	1.49	No	No	0	8	6
245	R:R:L131	R:R:V130	1.49	No	No	0	6	7
246	R:R:L295	R:R:V294	1.49	No	No	0	7	5
247	R:R:I88	R:R:M84	1.46	No	No	0	3	3
248	R:R:I33	R:R:K37	1.45	No	No	0	4	6
249	R:R:F72	R:R:P73	1.44	No	No	0	4	4
250	R:R:I33	R:R:L29	1.43	No	No	0	4	5
251	R:R:I47	R:R:L99	1.43	No	No	0	9	5
252	R:R:I88	R:R:L61	1.43	No	No	0	3	4
253	R:R:I234	R:R:L238	1.43	No	No	0	5	5
254	R:R:K123	R:R:L120	1.41	No	No	0	9	7
255	R:R:A146	R:R:F142	1.39	No	No	0	4	3
256	R:R:L295	R:R:L298	1.38	No	No	0	7	5
257	R:R:K285	R:R:Q289	1.36	No	No	0	6	7
258	R:R:H151	R:R:I150	1.33	Yes	No	0	2	3
259	R:R:F142	R:R:V139	1.31	No	No	0	3	4
260	R:R:H208	R:R:M205	1.31	No	No	0	9	9
261	R:R:F9	R:R:I8	1.26	Yes	No	0	4	6
262	R:R:H227	R:R:R228	1.13	No	No	0	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I5	5.97	4	0	4
2	R:R:F9	4.6525	4	0	4
3	R:R:E16	4.295	4	0	8
4	R:R:F17	14.55	5	4	5
5	R:R:R55	10.45	5	1	9
6	R:R:L58	3.9525	4	3	4
7	R:R:W66	6.77833	6	2	4
8	R:R:F76	4.2225	4	0	3
9	R:R:R83	6.78	4	0	3
10	R:R:W89	6.456	5	3	4
11	R:R:N93	8.5	4	3	8
12	R:R:H94	9.47	4	6	5
13	R:R:W98	11.8333	6	6	9
14	R:R:F106	5.785	4	5	7
15	R:R:F108	6.2675	4	0	8
16	R:R:T137	8.4625	4	6	8
17	R:R:H151	5.188	5	0	2
18	R:R:F175	6.504	5	0	2
19	R:R:F198	7.445	6	1	7
20	R:R:F236	6.555	4	1	9
21	R:R:Y240	10.4325	4	1	8
22	R:R:F247	8.076	5	0	3
23	R:R:F248	6.205	4	7	4
24	R:R:V251	4.455	4	0	3
25	R:R:Q266	4.495	4	2	3
26	R:R:M270	5.358	5	0	4
27	R:R:Y272	12.32	4	1	5
28	R:R:H276	13.75	4	1	9
29	W:W:?1	7.93125	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F9	R:R:I263	51.913	5.02	Yes	No	0	4	4
2	R:R:I263	R:R:Q266	53.6052	4.12	No	Yes	0	4	3
3	R:R:Q266	R:R:W66	22.3427	4.38	Yes	Yes	2	3	4
4	R:R:E16	R:R:M270	11.8167	4.06	Yes	Yes	0	8	4
5	R:R:L13	R:R:M270	40.125	4.24	No	Yes	0	4	4
6	R:R:L13	R:R:Q266	34.601	3.99	No	Yes	2	4	3
7	R:R:F17	R:R:F63	28.9394	40.73	Yes	No	0	5	4
8	R:R:F63	R:R:W66	27.1955	5.01	No	Yes	0	4	4
9	R:R:F17	R:R:M270	73.923	3.73	Yes	Yes	0	5	4
10	R:R:F17	R:R:W60	99.6386	10.02	Yes	No	4	5	3
11	R:R:I56	R:R:W60	100	4.7	No	No	0	6	3
12	R:R:I56	R:R:N24	99.4149	5.66	No	No	0	6	9
13	R:R:N24	R:R:R55	98.107	9.64	No	Yes	0	9	9
14	R:R:L287	R:R:N284	11.9027	12.36	No	No	0	9	9
15	R:R:L48	R:R:N284	21.7289	5.49	No	No	0	8	9
16	R:R:L280	R:R:L48	23.0941	4.15	No	No	0	9	8
17	R:R:H276	R:R:L280	24.1668	10.29	Yes	No	0	9	9
18	R:R:H276	R:R:R55	86.9615	12.41	Yes	Yes	1	9	9
19	R:R:D45	R:R:S42	14.8511	8.83	No	No	0	8	8
20	R:R:S42	R:R:V44	17.6849	4.85	No	No	0	8	6
21	R:R:V44	R:R:Y107	62.6628	3.79	No	No	0	6	9
22	R:R:Y107	W:W:?1	57.6722	13.25	No	Yes	0	9	0
23	R:R:H276	W:W:?1	70.5099	7.26	Yes	Yes	1	9	0
24	R:R:F106	R:R:V44	49.1138	5.24	Yes	No	0	7	6
25	R:R:L103	R:R:L280	10.6006	4.15	No	No	0	9	9
26	R:R:I62	R:R:M270	66.6781	10.2	No	Yes	0	4	4
27	R:R:I62	R:R:L58	66.0988	4.28	No	Yes	0	4	4
28	R:R:L58	R:R:W89	59.3185	4.56	Yes	Yes	3	4	4
29	R:R:L61	R:R:W89	22.6467	3.42	No	Yes	0	4	4
30	R:R:L61	R:R:L85	19.1074	4.15	No	No	0	4	2
31	R:R:L85	R:R:S65	17.9774	4.5	No	No	0	2	4
32	R:R:F76	R:R:S65	16.7728	2.64	Yes	No	0	3	4
33	R:R:F175	R:R:I152	10.549	3.77	Yes	No	0	2	3
34	R:R:F175	R:R:I179	24.9355	5.02	Yes	No	0	2	3
35	R:R:I148	R:R:I179	26.0655	4.42	No	No	0	4	3
36	R:R:I148	R:R:N144	27.1841	4.25	No	No	0	4	5
37	R:R:N144	R:R:T90	43.5209	7.31	No	No	0	5	5
38	R:R:T90	R:R:W89	45.3622	3.64	No	Yes	0	5	4
39	R:R:F186	R:R:N144	19.182	26.58	No	No	0	4	5
40	R:R:F186	R:R:H94	14.1456	9.05	No	Yes	0	4	5
41	R:R:F106	R:R:V126	45.5114	3.93	Yes	No	5	7	7
42	R:R:L109	R:R:V126	44.5477	4.47	No	No	0	7	7
43	R:R:F108	R:R:L109	43.3775	4.87	Yes	No	0	8	7
44	R:R:F108	R:R:M197	17.6103	9.95	Yes	No	0	8	8
45	R:R:M197	R:R:T105	16.1992	6.02	No	No	0	8	7
46	R:R:A112	R:R:F108	25.8418	4.16	No	Yes	0	8	8
47	R:R:F114	R:R:S204	17.6734	5.28	No	No	0	8	9
48	R:R:A112	R:R:S204	24.4995	3.42	No	No	0	8	9
49	R:R:F9	R:R:L264	38.0829	7.31	Yes	No	0	4	4
50	R:R:F247	R:R:L264	36.2875	7.31	Yes	No	0	3	4
51	R:R:F247	R:R:V251	17.421	3.93	Yes	Yes	0	3	3
52	R:R:F247	R:R:T184	11.6216	9.08	Yes	No	0	3	5
53	R:R:F198	W:W:?1	11.8798	11.8	Yes	Yes	1	7	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V44	R:R:Y107	3.79	0	No	No	6	9	2	1
R:R:R55	R:R:Y272	7.2	1	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	12.41	1	Yes	Yes	9	9	1	2
R:R:L103	R:R:Y107	12.89	0	No	No	9	9	2	1
R:R:L103	R:R:L280	4.15	0	No	No	9	9	2	2
R:R:G104	W:W:?1	8.28	0	No	Yes	8	0	1	0
R:R:Y107	W:W:?1	13.25	0	No	Yes	9	0	1	0
R:R:S194	W:W:?1	8.48	0	No	Yes	8	0	1	0
R:R:L195	R:R:L199	6.92	0	No	No	7	4	2	2
R:R:F237	R:R:L195	3.65	1	No	No	6	7	1	2
R:R:F198	R:R:L199	3.65	1	Yes	No	7	4	1	2
R:R:F198	R:R:I202	6.28	1	Yes	No	7	8	1	2
R:R:F198	R:R:V233	5.24	1	Yes	No	7	7	1	2
R:R:F198	R:R:I234	3.77	1	Yes	No	7	5	1	2
R:R:F198	R:R:F237	13.93	1	Yes	No	7	6	1	1
R:R:F198	W:W:?1	11.8	1	Yes	Yes	7	0	1	0
R:R:L201	W:W:?1	6.7	0	No	Yes	9	0	1	0
R:R:F237	W:W:?1	4.92	1	No	Yes	6	0	1	0
R:R:H276	R:R:Y272	25.04	1	Yes	Yes	9	5	1	2
R:R:H276	R:R:L280	10.29	1	Yes	No	9	9	1	2
R:R:H276	W:W:?1	7.26	1	Yes	Yes	9	0	1	0
R:R:I111	R:R:L201	2.85	0	No	No	9	9	2	1
R:R:G283	W:W:?1	2.76	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XQR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	251
Number of Links	262
Number of Hubs	29
Number of Links mediated by Hubs	113
Number of Communities	7
Number of Nodes involved in Communities	30
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	31324
Length Of Smallest Path	3
Average Path Length	15.6399
Length of Longest Path	34
Minimum Path Strength	1.315
Average Path Strength	6.78808
Maximum Path Strength	27.615
Minimum Path Correlation	0.7
Average Path Correlation	0.928382
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	45.325
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.3901
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • metal ion binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • exo-alpha-sialidase activity • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • bitter taste receptor activity • G protein-coupled receptor activity • carbohydrate metabolic process • catabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • primary metabolic process • metabolic process • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FLF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	FLF
Name	Flufenamic acid
Synonyms	FLUFENAMIC ACID
Identifier
Formula	C14 H10 F3 N O2
Molecular Weight	281.23
SMILES
PubChem	3371
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8XQR_nogp_Chain_R G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V K T K A H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	10.1038/s41467-024-54157-6
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol	Gi1/β1/γ1	2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol		2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	10.1038/s41586-024-07569-9

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XQR_nogp.zip

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