psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I10	R:R:L266	7.14	No	No	0	4	5
2	R:R:I18	R:R:L14	2.85	No	No	0	8	5
3	R:R:L14	R:R:V269	2.98	No	No	0	5	6
4	R:R:A15	R:R:S59	1.71	No	No	0	6	7
5	R:R:G55	R:R:I18	5.29	No	No	0	8	8
6	R:R:I19	R:R:V56	3.07	No	No	0	6	4
7	R:R:N22	R:R:T21	4.39	Yes	No	0	9	8
8	R:R:L273	R:R:T21	4.42	No	No	0	5	8
9	R:R:D51	R:R:N22	4.04	No	Yes	0	9	9
10	R:R:N22	R:R:P276	8.15	Yes	No	0	9	9
11	R:R:L24	R:R:T23	2.95	No	No	0	8	5
12	R:R:A280	R:R:V25	1.7	No	No	0	8	9
13	R:R:A26	R:R:A48	1.79	No	No	0	7	9
14	R:R:L31	R:R:Q289	9.32	No	Yes	0	5	7
15	R:R:E285	R:R:L32	5.3	No	Yes	0	6	7
16	R:R:L32	R:R:V286	2.98	Yes	No	0	7	9
17	R:R:L32	R:R:Q289	5.32	Yes	Yes	0	7	7
18	R:R:I33	R:R:L41	5.71	No	No	0	7	9
19	R:R:M117	R:R:V39	9.13	No	No	0	7	5
20	R:R:D102	R:R:S40	5.89	No	No	0	9	8
21	R:R:C42	R:R:I126	1.64	No	No	0	4	7
22	R:R:F43	R:R:L98	4.87	Yes	No	0	8	7
23	R:R:F43	R:R:I99	2.51	Yes	No	0	8	9
24	R:R:D102	R:R:F43	2.39	No	Yes	0	9	8
25	R:R:F43	R:R:I126	2.51	Yes	No	0	8	7
26	R:R:N46	R:R:T95	4.39	No	No	3	9	8
27	R:R:L129	R:R:N46	2.75	No	No	3	6	9
28	R:R:N46	R:R:W130	9.04	No	Yes	0	9	9
29	R:R:D51	R:R:L47	2.71	No	Yes	0	9	9
30	R:R:L47	R:R:T95	2.95	Yes	No	0	9	8
31	R:R:L47	R:R:Y279	3.52	Yes	Yes	0	9	9
32	R:R:A50	R:R:A91	1.79	No	No	0	8	7
33	R:R:D51	R:R:S272	8.83	No	No	0	9	9
34	R:R:G55	R:R:I54	3.53	No	Yes	0	8	8
35	R:R:I54	R:R:S88	6.19	Yes	No	0	8	6
36	R:R:G55	R:R:I58	3.53	No	No	0	8	7
37	R:R:A57	R:R:F84	2.77	No	No	0	4	3
38	R:R:A57	R:R:V85	1.7	No	No	0	4	7
39	R:R:G60	R:R:S59	3.71	No	No	0	7	7
40	R:R:D64	R:R:G60	3.35	No	No	0	4	7
41	R:R:L61	R:R:R81	4.86	No	No	0	5	6
42	R:R:D64	R:R:T63	2.89	No	No	0	4	5
43	R:R:L77	R:R:Q65	5.32	No	No	0	4	4
44	R:R:L80	R:R:T76	2.95	No	No	0	5	2
45	R:R:C78	R:R:Y151	4.03	No	Yes	2	9	4
46	R:R:C155	R:R:C78	7.28	No	No	2	9	9
47	R:R:C78	R:R:V160	1.71	No	No	2	9	5
48	R:R:L141	R:R:S79	4.5	No	No	0	6	4
49	R:R:M82	R:R:V160	3.04	No	No	0	5	5
50	R:R:F161	R:R:M82	2.49	No	No	0	4	5
51	R:R:G137	R:R:T86	1.82	No	No	0	7	5
52	R:R:F157	R:R:T86	2.59	No	No	0	4	5
53	R:R:G137	R:R:S87	1.86	No	No	0	7	5
54	R:R:A90	R:R:S133	1.71	No	No	0	7	8
55	R:R:A90	R:R:I136	3.25	No	No	0	7	6
56	R:R:A91	R:R:W130	3.89	No	Yes	0	7	9
57	R:R:A91	R:R:S133	1.71	No	No	0	7	8
58	R:R:F234	R:R:V93	2.62	Yes	No	0	9	7
59	R:R:L129	R:R:T95	2.95	No	No	3	6	8
60	R:R:F234	R:R:V96	3.93	Yes	No	0	9	9
61	R:R:V96	R:R:Y279	2.52	No	Yes	0	9	9
62	R:R:M97	R:R:T100	3.01	No	Yes	1	7	8
63	R:R:F181	R:R:M97	2.49	Yes	No	1	8	7
64	R:R:F181	R:R:T100	2.59	Yes	Yes	1	8	8
65	R:R:F184	R:R:T100	2.59	Yes	Yes	0	6	8
66	R:R:T100	R:R:Y185	4.99	Yes	Yes	1	8	9
67	R:R:F101	R:R:L105	8.53	No	No	0	5	5
68	R:R:F101	R:R:F184	4.29	No	Yes	0	5	6
69	R:R:D102	R:R:Y113	3.45	No	No	0	9	9
70	R:R:R103	R:R:Y185	3.09	No	Yes	0	9	9
71	R:R:R103	R:R:Y279	2.06	No	Yes	0	9	9
72	R:R:K108	R:R:Y104	10.75	No	No	0	6	8
73	R:R:F184	R:R:Y104	5.16	Yes	No	0	6	8
74	R:R:A106	R:R:Y113	5.34	No	No	0	9	9
75	R:R:Q109	R:R:R112	4.67	No	No	0	5	5
76	R:R:M117	R:R:Y113	9.58	No	No	0	7	9
77	R:R:G119	R:R:S118	1.86	No	No	0	1	8
78	R:R:F120	R:R:S118	2.64	No	No	4	3	8
79	R:R:S118	R:R:V121	3.23	No	No	4	8	6
80	R:R:F120	R:R:V121	3.93	No	No	4	3	6
81	R:R:A122	R:R:G123	1.95	No	No	0	6	1
82	R:R:A127	R:R:G128	1.95	No	No	0	3	3
83	R:R:W130	R:R:Y134	5.79	Yes	No	0	9	4
84	R:R:F138	R:R:Y134	2.06	No	No	0	4	4
85	R:R:G137	R:R:P140	4.06	No	No	0	7	5
86	R:R:L139	R:R:P140	1.64	No	No	0	4	5
87	R:R:F165	R:R:P140	10.11	Yes	No	0	6	5
88	R:R:F161	R:R:L141	4.87	No	No	0	4	6
89	R:R:I143	R:R:P144	5.08	No	No	0	4	2
90	R:R:I143	R:R:M145	5.83	No	No	5	4	3
91	R:R:F146	R:R:I143	21.35	Yes	No	5	2	4
92	R:R:P144	R:R:Q147	3.16	No	No	0	2	1
93	R:R:F146	R:R:M145	4.98	Yes	No	5	2	3
94	R:R:F146	R:R:F165	4.29	Yes	Yes	0	2	6
95	R:R:A150	R:R:T149	3.36	No	No	0	2	1
96	R:R:C155	R:R:Y151	2.69	No	Yes	2	9	4
97	R:R:V160	R:R:Y151	8.83	No	Yes	2	5	4
98	R:R:G153	R:R:K152	1.74	No	No	0	3	1
99	R:R:A159	R:R:S156	1.71	No	No	0	4	4
100	R:R:F157	R:R:F241	2.14	No	No	0	4	6
101	R:R:F158	R:R:Q248	18.74	No	No	0	3	3
102	R:R:F158	R:R:W265	3.01	No	No	0	3	3
103	R:R:F161	R:R:F165	4.29	No	Yes	0	4	6
104	R:R:H162	R:R:P163	7.63	No	No	0	5	3
105	R:R:H162	R:R:H164	7.17	No	No	0	5	2
106	R:R:F241	R:R:V166	2.62	No	No	0	6	6
107	R:R:F174	R:R:S170	7.93	No	No	0	8	6
108	R:R:L242	R:R:S170	3	No	No	0	6	6
109	R:R:C171	R:R:V172	1.71	No	No	0	4	4
110	R:R:F174	R:R:W238	33.07	No	Yes	0	8	8
111	R:R:F175	R:R:P176	4.33	No	No	0	5	5
112	R:R:F175	R:R:L179	3.65	No	No	0	5	4
113	R:R:F234	R:R:M178	3.73	Yes	No	1	9	5
114	R:R:M178	R:R:W238	9.31	No	Yes	1	5	8
115	R:R:F181	R:R:Y185	7.22	Yes	Yes	1	8	9
116	R:R:F181	R:R:I231	6.28	Yes	No	0	8	7
117	R:R:F181	R:R:F234	6.43	Yes	Yes	1	8	9
118	R:R:C186	R:R:V182	1.71	No	No	0	3	5
119	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
120	R:R:D187	R:R:F183	3.58	No	No	0	5	3
121	R:R:M188	R:R:Y185	2.39	No	Yes	0	9	9
122	R:R:V227	R:R:Y185	6.31	No	Yes	0	8	9
123	R:R:L230	R:R:Y185	3.52	No	Yes	0	8	9
124	R:R:L189	R:R:L224	4.15	No	No	0	7	7
125	R:R:L189	R:R:V227	4.47	No	No	0	7	8
126	R:R:K190	R:R:M194	4.32	No	No	0	3	4
127	R:R:R200	R:R:S196	6.59	No	No	6	4	5
128	R:R:D220	R:R:S196	8.83	No	No	6	7	5
129	R:R:P218	R:R:R200	5.76	No	No	0	5	4
130	R:R:D220	R:R:R200	5.96	No	No	6	7	4
131	R:R:F221	R:R:P218	5.78	No	No	0	4	5
132	R:R:K222	R:R:T226	4.5	No	No	0	8	8
133	R:R:R225	W:W:?1	1.73	No	Yes	0	6	0
134	R:R:T226	R:R:W282	3.64	No	No	0	8	7
135	R:R:I231	R:R:V227	3.07	No	No	0	7	8
136	R:R:V229	W:W:?1	9.22	No	Yes	0	7	0
137	R:R:L230	R:R:Y279	3.52	No	Yes	0	8	9
138	R:R:L230	R:R:W282	2.28	No	No	0	8	7
139	R:R:G232	W:W:?1	2.44	No	Yes	0	5	0
140	R:R:N271	R:R:S233	4.47	No	No	0	9	7
141	R:R:L274	R:R:S233	3	No	No	0	5	7
142	R:R:I278	R:R:S233	3.1	Yes	No	0	8	7
143	R:R:F234	R:R:W238	9.02	Yes	Yes	1	9	8
144	R:R:S237	R:R:W238	4.94	No	Yes	0	7	8
145	R:R:N271	R:R:S237	2.98	No	No	0	9	7
146	R:R:T239	R:R:W238	4.85	No	Yes	0	4	8
147	R:R:P240	R:R:T239	3.5	No	No	0	9	4
148	R:R:L264	R:R:P240	1.64	No	No	0	4	9
149	R:R:F241	R:R:W265	3.01	No	No	0	6	3
150	R:R:Q248	R:R:T244	4.25	No	No	0	3	4
151	R:R:L264	R:R:T244	4.42	No	No	0	4	4
152	R:R:E261	R:R:Q248	2.55	No	No	0	4	3
153	R:R:R262	R:R:W265	7	No	No	0	3	3
154	R:R:L267	R:R:Y263	3.52	No	No	0	7	4
155	R:R:N271	R:R:N275	4.09	No	No	0	9	9
156	R:R:L274	W:W:?1	1.98	No	Yes	0	5	0
157	R:R:N275	R:R:Y279	5.81	No	Yes	0	9	9
158	R:R:I278	R:R:Y279	8.46	Yes	Yes	0	8	9
159	R:R:I278	R:R:W282	2.35	Yes	No	0	8	7
160	R:R:I278	W:W:?1	2.04	Yes	Yes	0	8	0
161	R:R:R287	R:R:Y281	3.09	No	No	7	8	5
162	R:R:L290	R:R:Y281	2.34	No	No	0	5	5
163	R:R:Y281	R:R:Y291	1.99	No	No	7	5	2
164	R:R:E285	R:R:Q283	7.65	No	No	0	6	8
165	R:R:Q283	R:R:V286	7.16	No	No	0	8	9
166	R:R:K284	R:R:L288	5.64	No	No	0	5	4
167	R:R:R287	R:R:Y291	7.2	No	No	7	8	2
168	R:R:H292	R:R:L288	10.29	No	No	0	5	4
169	R:R:H292	R:R:Y291	2.18	No	No	0	5	2
170	R:R:A294	R:R:L295	3.15	No	No	0	6	3
171	R:R:A89	R:R:I54	1.62	No	Yes	0	6	8
172	R:R:A235	R:R:M178	1.61	No	No	0	6	5
173	R:R:V25	R:R:V29	1.6	No	No	0	9	8
174	R:R:S79	R:R:T76	1.6	No	No	0	4	2
175	R:R:C125	R:R:L98	1.59	No	No	0	6	7
176	R:R:A26	R:R:L45	1.58	No	No	0	7	6
177	R:R:A83	R:R:L141	1.58	No	No	0	6	6
178	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
179	R:R:P163	R:R:Q148	1.58	No	No	0	3	4
180	R:R:A235	R:R:L236	1.58	No	No	0	6	4
181	R:R:C186	R:R:D187	1.56	No	No	0	3	5
182	R:R:I54	R:R:S92	1.55	Yes	No	0	8	9
183	R:R:I33	R:R:V29	1.54	No	No	0	7	8
184	R:R:I58	R:R:V85	1.54	No	No	0	7	7
185	R:R:I136	R:R:V132	1.54	No	No	0	6	3
186	R:R:I246	R:R:V247	1.54	No	No	0	5	4
187	R:R:I19	R:R:T52	1.52	No	No	0	6	6
188	R:R:A28	R:R:Q289	1.52	No	Yes	0	7	7
189	R:R:M117	R:R:V121	1.52	No	No	0	7	6
190	R:R:I243	R:R:T239	1.52	No	No	0	5	4
191	R:R:L53	R:R:S88	1.5	No	No	0	8	6
192	R:R:L94	R:R:S133	1.5	No	No	0	5	8
193	R:R:L17	R:R:V13	1.49	No	No	0	4	4
194	R:R:L31	R:R:V27	1.49	No	No	0	5	5
195	R:R:L61	R:R:V85	1.49	No	No	0	5	7
196	R:R:N22	R:R:T52	1.46	Yes	No	0	9	6
197	R:R:I107	R:R:M188	1.46	No	No	0	8	9
198	R:R:I116	R:R:K115	1.45	No	No	0	5	4
199	R:R:I191	R:R:K190	1.45	No	No	0	6	3
200	R:R:I99	R:R:L47	1.43	No	Yes	0	9	9
201	R:R:S228	W:W:?1	1.43	No	Yes	0	7	0
202	R:R:I18	R:R:N22	1.42	No	Yes	0	8	9
203	R:R:Q283	R:R:T44	1.42	No	No	0	8	7
204	R:R:K35	R:R:L32	1.41	No	Yes	0	6	7
205	R:R:L11	R:R:L14	1.38	No	No	0	6	5
206	R:R:L17	R:R:L273	1.38	No	No	0	4	5
207	R:R:L32	R:R:L41	1.38	Yes	No	0	7	9
208	R:R:L61	R:R:L62	1.38	No	No	0	5	6
209	R:R:L131	R:R:L135	1.38	No	No	0	3	3
210	R:R:L167	R:R:L242	1.38	No	No	0	5	6
211	R:R:L32	R:R:N36	1.37	Yes	No	0	7	9
212	R:R:H164	R:R:T168	1.37	No	No	0	2	4
213	R:R:K108	R:R:Q109	1.36	No	No	0	6	5
214	R:R:K201	R:R:Q197	1.36	No	No	0	5	5
215	R:R:M293	R:R:Q289	1.36	No	Yes	0	5	7
216	R:R:E285	R:R:K284	1.35	No	No	0	6	5
217	R:R:A159	R:R:Y151	1.33	No	Yes	0	4	4
218	R:R:V49	R:R:W130	1.23	No	Yes	0	6	9
219	R:R:F165	R:R:L169	1.22	Yes	No	0	6	6
220	R:R:F184	R:R:L180	1.22	Yes	No	0	6	5
221	R:R:F146	R:R:H162	1.13	Yes	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N22	3.892	5	0	9
2	R:R:L32	2.96	6	0	7
3	R:R:F43	3.07	4	0	8
4	R:R:L47	2.6525	4	0	9
5	R:R:I54	3.2225	4	0	8
6	R:R:T100	3.295	4	1	8
7	R:R:W130	4.9875	4	0	9
8	R:R:F146	7.9375	4	5	2
9	R:R:Y151	4.22	4	2	4
10	R:R:F165	4.9775	4	0	6
11	R:R:F181	5.002	5	1	8
12	R:R:F184	3.724	5	0	6
13	R:R:Y185	4.58667	6	1	9
14	R:R:F234	5.146	5	1	9
15	R:R:W238	12.238	5	1	8
16	R:R:I278	3.9875	4	0	8
17	R:R:Y279	4.315	6	0	9
18	R:R:Q289	4.38	4	0	7
19	W:W:?1	3.14	6	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I18	R:R:N22	38.2067	1.42	No	Yes	0	8	9
2	R:R:D51	R:R:N22	55.3642	4.04	No	Yes	0	9	9
3	R:R:D51	R:R:L47	58.8877	2.71	No	Yes	0	9	9
4	R:R:I99	R:R:L47	36.1688	1.43	No	Yes	0	9	9
5	R:R:F43	R:R:I99	34.1047	2.51	Yes	No	0	8	9
6	R:R:D102	R:R:F43	23.3894	2.39	No	Yes	0	9	8
7	R:R:D102	R:R:Y113	18.9193	3.45	No	No	0	9	9
8	R:R:M117	R:R:Y113	14.3439	9.58	No	No	0	7	9
9	R:R:L47	R:R:T95	31.9616	2.95	Yes	No	0	9	8
10	R:R:N46	R:R:T95	27.544	4.39	No	No	3	9	8
11	R:R:N46	R:R:W130	25.5193	9.04	No	Yes	0	9	9
12	R:R:L47	R:R:Y279	100	3.52	Yes	Yes	0	9	9
13	R:R:A91	R:R:W130	16.6448	3.89	No	Yes	0	7	9
14	R:R:G55	R:R:I18	29.8974	5.29	No	No	0	8	8
15	R:R:G55	R:R:I54	12.0168	3.53	No	Yes	0	8	8
16	R:R:G55	R:R:I58	16.6448	3.53	No	No	0	8	7
17	R:R:I58	R:R:V85	14.3439	1.54	No	No	0	7	7
18	R:R:V96	R:R:Y279	56.6001	2.52	No	Yes	0	9	9
19	R:R:F234	R:R:V96	56.4686	3.93	Yes	No	0	9	9
20	R:R:F234	R:R:W238	70.2735	9.02	Yes	Yes	1	9	8
21	R:R:T239	R:R:W238	78.0174	4.85	No	Yes	0	4	8
22	R:R:P240	R:R:T239	75.5719	3.5	No	No	0	9	4
23	R:R:L264	R:R:P240	74.3098	1.64	No	No	0	4	9
24	R:R:L264	R:R:T244	73.0213	4.42	No	No	0	4	4
25	R:R:Q248	R:R:T244	71.7065	4.25	No	No	0	3	4
26	R:R:F158	R:R:Q248	68.9982	18.74	No	No	0	3	3
27	R:R:F158	R:R:W265	67.5782	3.01	No	No	0	3	3
28	R:R:F241	R:R:W265	64.7121	3.01	No	No	0	6	3
29	R:R:F157	R:R:F241	61.7144	2.14	No	No	0	4	6
30	R:R:F157	R:R:T86	60.2156	2.59	No	No	0	4	5
31	R:R:G137	R:R:T86	58.7562	1.82	No	No	0	7	5
32	R:R:G137	R:R:P140	55.5745	4.06	No	No	0	7	5
33	R:R:F165	R:R:P140	52.2877	10.11	Yes	No	0	6	5
34	R:R:F161	R:R:F165	30.3576	4.29	No	Yes	0	4	6
35	R:R:F161	R:R:L141	11.4252	4.87	No	No	0	4	6
36	R:R:M82	R:R:V160	15.8165	3.04	No	No	0	5	5
37	R:R:F161	R:R:M82	17.9727	2.49	No	No	0	4	5
38	R:R:A91	R:R:S133	12.0168	1.71	No	No	0	7	8
39	R:R:F181	R:R:F234	25.7165	6.43	Yes	Yes	1	8	9
40	R:R:R103	R:R:Y279	25.0723	2.06	No	Yes	0	9	9
41	R:R:R103	R:R:Y185	24.4281	3.09	No	Yes	0	9	9
42	R:R:F181	R:R:Y185	14.1993	7.22	Yes	Yes	1	8	9
43	R:R:L230	R:R:Y279	29.6214	3.52	No	Yes	0	8	9
44	R:R:L230	R:R:Y185	30.4628	3.52	No	Yes	0	8	9
45	R:R:T100	R:R:Y185	31.909	4.99	Yes	Yes	1	8	9
46	R:R:F184	R:R:T100	38.1015	2.59	Yes	Yes	0	6	8
47	R:R:F184	R:R:Y104	15.1722	5.16	Yes	No	0	6	8
48	R:R:K108	R:R:Y104	12.1877	10.75	No	No	0	6	8
49	R:R:F146	R:R:F165	22.2062	4.29	Yes	Yes	0	2	6
50	R:R:F146	R:R:H162	11.4252	1.13	Yes	No	0	2	5
51	R:R:V227	R:R:Y185	11.2806	6.31	No	Yes	0	8	9
52	R:R:F183	R:R:F184	12.1877	5.36	No	Yes	0	3	6
53	R:R:L230	R:R:W282	10.8336	2.28	No	No	0	8	7
54	R:R:I278	R:R:Y279	22.7058	8.46	Yes	Yes	0	8	9
55	R:R:I278	W:W:?1	18.5643	2.04	Yes	Yes	0	8	0
56	R:R:N271	R:R:S237	13.1607	2.98	No	No	0	9	7
57	R:R:F181	R:R:T100	10.8467	2.59	Yes	Yes	1	8	8
58	R:R:N271	R:R:S233	10.9387	4.47	No	No	0	9	7
59	R:R:S237	R:R:W238	13.1738	4.94	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R225	W:W:?1	1.73	No	Yes	6	0	1	0
R:R:V229	W:W:?1	9.22	No	Yes	7	0	1	0
R:R:G232	W:W:?1	2.44	No	Yes	5	0	1	0
R:R:L274	R:R:S233	3	No	No	5	7	1	2
R:R:I278	R:R:S233	3.1	Yes	No	8	7	1	2
R:R:L274	W:W:?1	1.98	No	Yes	5	0	1	0
R:R:I278	R:R:Y279	8.46	Yes	Yes	8	9	1	2
R:R:I278	R:R:W282	2.35	Yes	No	8	7	1	2
R:R:I278	W:W:?1	2.04	Yes	Yes	8	0	1	0
R:R:S228	W:W:?1	1.43	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L80_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.64
Number of Linked Nodes	224
Number of Links	221
Number of Hubs	19
Number of Links mediated by Hubs	78
Number of Communities	7
Number of Nodes involved in Communities	26
Number of Links involved in Communities	29

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	15893
Length Of Smallest Path	3
Average Path Length	13.2037
Length of Longest Path	32
Minimum Path Strength	1.375
Average Path Strength	4.31038
Maximum Path Strength	21.19
Minimum Path Correlation	0.71
Average Path Correlation	0.937117
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	63.046
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.2126
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cation binding • ion binding • phosphatidylcholine binding • phospholipid binding • lipid binding • quaternary ammonium group binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • establishment of protein localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • secretion by cell • signal release • intracellular protein localization • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DR7
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	DR7
Name	Atazanavir
Synonyms	ATAZANAVIR; METHYL [(1S,4S,5S,10S)-4-BENZYL-1,10-DI-TERT-BUTYL-5-HYDROXY-2,9,12-TRIOXO-7-(4-PYRIDIN-2-YLBENZYL)-13-OXA-3,7,8,11-TETRAAZATETRADEC-1-YL]CARBAMATE
Identifier
Formula	C38 H52 N6 O7
Molecular Weight	704.855
SMILES
PubChem	148192
Formal Charge	0
Total Atoms	103
Total Chiral Atoms	4
Total Bonds	105
Total Aromatic Bonds	19


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>9L80_nogp_Chain_R G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M A P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M A L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-		2.82	2024-06-19	To be published
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	9L79	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-12-31	To be published
	9L79 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.98	2025-12-31	To be published
	9L80	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir	chim(NtGi1-Gs)/β1/γ2	3.33	2025-12-31	To be published
	9L80 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir		3.33	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9L80_nogp.zip

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