psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M82	2.69	Yes	No	1	0	5
2	L:L:?1	R:R:V85	3.79	Yes	No	1	0	7
3	L:L:?1	R:R:T86	3.75	Yes	No	1	0	5
4	L:L:?1	R:R:A89	4	Yes	No	0	0	6
5	L:L:?1	R:R:V93	1.89	Yes	No	1	0	7
6	L:L:?1	R:R:L94	1.76	Yes	No	0	0	5
7	L:L:?1	R:R:F157	18.57	Yes	Yes	1	0	4
8	L:L:?1	R:R:L169	3.52	Yes	No	0	0	6
9	L:L:?1	R:R:F174	7.74	Yes	Yes	1	0	8
10	L:L:?1	R:R:W238	13.02	Yes	Yes	1	0	8
11	L:L:?1	R:R:F241	9.29	Yes	No	1	0	6
12	L:L:?1	R:R:R262	6.17	Yes	No	0	0	3
13	L:L:?1	R:R:W265	16.64	Yes	No	0	0	3
14	R:R:F7	R:R:I10	5.02	No	No	0	5	4
15	R:R:F7	R:R:L266	3.65	No	No	0	5	5
16	R:R:I10	R:R:V9	1.54	No	No	0	4	5
17	R:R:I58	R:R:L11	2.85	No	No	0	7	6
18	R:R:L11	R:R:L62	2.77	No	No	0	6	6
19	R:R:A12	R:R:L62	3.15	No	No	0	4	6
20	R:R:S16	R:R:V13	3.23	No	No	4	4	4
21	R:R:L17	R:R:V13	1.49	No	No	4	4	4
22	R:R:L14	R:R:V269	1.49	No	No	0	5	6
23	R:R:A15	R:R:I58	3.25	No	No	0	6	7
24	R:R:A15	R:R:S59	1.71	No	No	0	6	7
25	R:R:L17	R:R:S16	1.5	No	No	4	4	4
26	R:R:I18	R:R:N22	4.25	Yes	Yes	2	8	9
27	R:R:G55	R:R:I18	1.76	No	Yes	0	8	8
28	R:R:I18	R:R:S272	10.84	Yes	No	2	8	9
29	R:R:I18	R:R:L273	2.85	Yes	No	0	8	5
30	R:R:G55	R:R:I19	3.53	No	No	0	8	6
31	R:R:I19	R:R:S59	1.55	No	No	0	6	7
32	R:R:P276	R:R:T21	1.75	Yes	No	0	9	8
33	R:R:D51	R:R:N22	6.73	Yes	Yes	2	9	9
34	R:R:N22	R:R:S272	4.47	Yes	No	2	9	9
35	R:R:N22	R:R:P276	4.89	Yes	Yes	0	9	9
36	R:R:V25	R:R:V29	1.6	No	Yes	0	9	8
37	R:R:P276	R:R:V25	1.77	Yes	No	0	9	9
38	R:R:A280	R:R:V25	1.7	No	No	0	8	9
39	R:R:A26	R:R:L45	1.58	No	No	0	7	6
40	R:R:A26	R:R:A48	1.79	No	No	0	7	9
41	R:R:A28	R:R:L290	3.15	No	No	0	7	5
42	R:R:L41	R:R:V29	1.49	Yes	Yes	0	9	8
43	R:R:T44	R:R:V29	3.17	No	Yes	0	7	8
44	R:R:L45	R:R:V29	1.49	No	Yes	0	6	8
45	R:R:L30	R:R:L45	4.15	No	No	0	3	6
46	R:R:L31	R:R:Q289	7.99	No	No	0	5	7
47	R:R:K35	R:R:L32	2.82	No	Yes	0	6	7
48	R:R:L32	R:R:V286	1.49	Yes	No	0	7	9
49	R:R:L32	R:R:Q289	3.99	Yes	No	0	7	7
50	R:R:I33	R:R:L41	4.28	No	Yes	0	7	9
51	R:R:M117	R:R:V39	1.52	No	No	0	7	5
52	R:R:A122	R:R:V39	1.7	No	No	0	6	5
53	R:R:C42	R:R:I126	1.64	No	No	0	4	7
54	R:R:F43	R:R:L98	6.09	No	No	0	8	7
55	R:R:D102	R:R:F43	5.97	No	No	0	9	8
56	R:R:F43	R:R:I126	5.02	No	No	0	8	7
57	R:R:N46	R:R:T95	2.92	No	No	0	9	8
58	R:R:N46	R:R:W130	4.52	No	No	0	9	9
59	R:R:D51	R:R:L47	5.43	Yes	Yes	2	9	9
60	R:R:L47	R:R:T95	4.42	Yes	No	0	9	8
61	R:R:L47	R:R:V96	1.49	Yes	No	0	9	9
62	R:R:L47	R:R:N275	5.49	Yes	No	2	9	9
63	R:R:L53	R:R:V49	1.49	No	No	0	8	6
64	R:R:A50	R:R:S92	1.71	No	No	0	8	9
65	R:R:D51	R:R:S92	2.94	Yes	No	0	9	9
66	R:R:D51	R:R:S272	5.89	Yes	No	2	9	9
67	R:R:D51	R:R:N275	6.73	Yes	No	2	9	9
68	R:R:L53	R:R:S88	3	No	No	0	8	6
69	R:R:I54	R:R:S88	1.55	No	No	0	8	6
70	R:R:I54	R:R:S92	1.55	No	No	0	8	9
71	R:R:A57	R:R:F84	2.77	No	No	0	4	3
72	R:R:I58	R:R:W265	2.35	No	No	0	7	3
73	R:R:L62	R:R:S59	1.5	No	No	0	6	7
74	R:R:G60	R:R:L61	1.71	No	No	0	7	5
75	R:R:D64	R:R:L61	4.07	No	No	0	4	5
76	R:R:D64	R:R:R81	4.76	No	No	0	4	6
77	R:R:C155	R:R:D64	1.56	No	No	0	9	4
78	R:R:Q74	R:R:T73	2.83	No	No	0	7	5
79	R:R:C78	R:R:T73	1.69	No	No	6	9	5
80	R:R:C155	R:R:T73	1.69	No	No	6	9	5
81	R:R:L77	R:R:Q74	19.96	No	No	0	4	7
82	R:R:K75	R:R:T76	7.51	No	No	0	3	2
83	R:R:C155	R:R:C78	7.28	No	No	6	9	9
84	R:R:C78	R:R:V160	1.71	No	Yes	0	9	5
85	R:R:S79	R:R:V160	4.85	No	Yes	0	4	5
86	R:R:F157	R:R:M82	7.46	Yes	No	1	4	5
87	R:R:M82	R:R:V160	3.04	No	Yes	0	5	5
88	R:R:A83	R:R:F138	4.16	No	Yes	0	6	4
89	R:R:A83	R:R:L141	1.58	No	No	0	6	6
90	R:R:F84	R:R:S88	5.28	No	No	0	3	6
91	R:R:T86	R:R:V85	1.59	No	No	1	5	7
92	R:R:G137	R:R:S87	1.86	No	No	0	7	5
93	R:R:F138	R:R:S87	2.64	Yes	No	0	4	5
94	R:R:A91	R:R:L129	1.58	No	No	0	7	6
95	R:R:A91	R:R:W130	3.89	No	No	5	7	9
96	R:R:A91	R:R:S133	3.42	No	No	5	7	8
97	R:R:V93	R:R:W238	2.45	No	Yes	1	7	8
98	R:R:L129	R:R:L94	2.77	No	No	0	6	5
99	R:R:L129	R:R:T95	2.95	No	No	0	6	8
100	R:R:F234	R:R:V96	3.93	No	No	0	9	9
101	R:R:F181	R:R:M97	2.49	Yes	No	0	8	7
102	R:R:I99	R:R:R103	2.51	No	No	0	9	9
103	R:R:F181	R:R:T100	9.08	Yes	No	7	8	8
104	R:R:F184	R:R:T100	3.89	Yes	No	0	6	8
105	R:R:T100	R:R:Y185	4.99	No	Yes	7	8	9
106	R:R:F101	R:R:L105	6.09	No	No	0	5	5
107	R:R:F101	R:R:F184	6.43	No	Yes	0	5	6
108	R:R:D102	R:R:Y113	5.75	No	No	0	9	9
109	R:R:R103	R:R:Y185	4.12	No	Yes	0	9	9
110	R:R:K108	R:R:Y104	4.78	No	Yes	8	6	8
111	R:R:F184	R:R:Y104	11.35	Yes	Yes	0	6	8
112	R:R:D187	R:R:Y104	5.75	No	Yes	8	5	8
113	R:R:M188	R:R:Y104	2.39	No	Yes	0	9	8
114	R:R:A106	R:R:Y113	4	No	No	0	9	9
115	R:R:I107	R:R:I191	2.94	No	No	0	8	6
116	R:R:D187	R:R:K108	6.91	No	No	8	5	6
117	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
118	R:R:M117	R:R:Y113	8.38	No	No	0	7	9
119	R:R:M117	R:R:V121	3.04	No	No	0	7	6
120	R:R:G119	R:R:S118	1.86	No	No	0	1	8
121	R:R:S118	R:R:V121	1.62	No	No	0	8	6
122	R:R:A122	R:R:G123	1.95	No	No	0	6	1
123	R:R:A127	R:R:G128	1.95	No	No	0	3	3
124	R:R:S133	R:R:W130	3.71	No	No	5	8	9
125	R:R:I136	R:R:V132	1.54	No	No	0	6	3
126	R:R:F138	R:R:Y134	10.32	Yes	No	0	4	4
127	R:R:L135	R:R:L139	4.15	No	No	0	3	4
128	R:R:G137	R:R:I136	3.53	No	No	0	7	6
129	R:R:L139	R:R:P140	1.64	No	Yes	0	4	5
130	R:R:I143	R:R:P140	1.69	Yes	Yes	3	4	5
131	R:R:F146	R:R:P140	2.89	No	Yes	3	2	5
132	R:R:F165	R:R:P140	5.78	No	Yes	3	6	5
133	R:R:G142	R:R:Q147	1.64	No	No	0	5	1
134	R:R:I143	R:R:P144	5.08	Yes	No	3	4	2
135	R:R:I143	R:R:M145	4.37	Yes	No	3	4	3
136	R:R:F146	R:R:I143	7.54	No	Yes	3	2	4
137	R:R:M145	R:R:P144	3.35	No	No	3	3	2
138	R:R:F146	R:R:F165	7.5	No	No	3	2	6
139	R:R:Q148	R:R:T149	5.67	No	No	0	4	1
140	R:R:H162	R:R:Q148	11.13	No	No	9	5	4
141	R:R:P163	R:R:Q148	1.58	No	No	9	3	4
142	R:R:G153	R:R:K152	1.74	No	No	0	3	1
143	R:R:F157	R:R:F158	2.14	Yes	No	0	4	3
144	R:R:F157	R:R:F161	5.36	Yes	No	0	4	4
145	R:R:F158	R:R:Y257	4.13	No	No	0	3	4
146	R:R:F161	R:R:V160	3.93	No	Yes	0	4	5
147	R:R:H162	R:R:P163	10.68	No	No	9	5	3
148	R:R:H162	R:R:H164	13.14	No	No	0	5	2
149	R:R:P163	R:R:Q248	3.16	No	Yes	0	3	3
150	R:R:H164	R:R:V249	4.15	No	No	0	2	4
151	R:R:G245	R:R:V166	1.84	No	No	0	6	6
152	R:R:I246	R:R:L167	5.71	No	No	0	5	5
153	R:R:C171	R:R:S170	1.72	No	No	0	4	6
154	R:R:L242	R:R:S170	6.01	No	No	0	6	6
155	R:R:I246	R:R:S170	3.1	No	No	0	5	6
156	R:R:C171	R:R:V172	1.71	No	No	0	4	4
157	R:R:G173	R:R:V172	3.68	No	No	0	6	4
158	R:R:G173	R:R:P176	2.03	No	No	0	6	5
159	R:R:F174	R:R:F175	2.14	Yes	No	0	8	5
160	R:R:F174	R:R:W238	2	Yes	Yes	1	8	8
161	R:R:F174	R:R:L242	4.87	Yes	No	0	8	6
162	R:R:A235	R:R:M178	1.61	No	No	0	6	5
163	R:R:F184	R:R:L180	2.44	Yes	No	0	6	5
164	R:R:F181	R:R:Y185	6.19	Yes	Yes	7	8	9
165	R:R:F181	R:R:I231	2.51	Yes	No	0	8	7
166	R:R:F181	R:R:F234	8.57	Yes	No	0	8	9
167	R:R:C186	R:R:V182	1.71	No	No	0	3	5
168	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
169	R:R:M188	R:R:Y185	5.99	No	Yes	0	9	9
170	R:R:L230	R:R:Y185	5.86	No	Yes	0	8	9
171	R:R:D187	R:R:K190	2.77	No	No	0	5	3
172	R:R:L189	R:R:S193	1.5	No	No	0	7	6
173	R:R:A223	R:R:L189	1.58	No	No	0	8	7
174	R:R:I191	R:R:M194	2.92	No	No	0	6	4
175	R:R:H195	R:R:I191	2.65	No	No	0	8	6
176	R:R:Q197	R:R:R200	4.67	No	No	0	5	4
177	R:R:F221	R:R:K222	2.48	No	No	0	4	8
178	R:R:A223	R:R:F221	2.77	No	No	0	8	4
179	R:R:A223	R:R:L224	1.58	No	No	0	8	7
180	R:R:T226	R:R:W282	2.43	No	No	0	8	7
181	R:R:I231	R:R:V227	1.54	No	No	0	7	8
182	R:R:I278	R:R:V229	3.07	Yes	No	0	8	7
183	R:R:G232	R:R:I231	1.76	No	No	0	5	7
184	R:R:G232	R:R:L236	1.71	No	No	0	5	4
185	R:R:N271	R:R:S233	1.49	No	No	0	9	7
186	R:R:I278	R:R:S233	3.1	Yes	No	0	8	7
187	R:R:S237	R:R:W238	3.71	No	Yes	1	7	8
188	R:R:N271	R:R:S237	8.94	No	No	1	9	7
189	R:R:F241	R:R:W238	5.01	No	Yes	1	6	8
190	R:R:G268	R:R:W238	9.85	No	Yes	0	7	8
191	R:R:N271	R:R:W238	2.26	No	Yes	1	9	8
192	R:R:P240	R:R:T239	3.5	No	No	0	9	4
193	R:R:L264	R:R:P240	1.64	No	No	0	4	9
194	R:R:L267	R:R:P240	1.64	No	No	0	7	9
195	R:R:E261	R:R:F241	5.83	No	No	0	4	6
196	R:R:I243	R:R:T244	4.56	No	Yes	0	5	4
197	R:R:G245	R:R:T244	1.82	No	Yes	0	6	4
198	R:R:E261	R:R:T244	4.23	No	Yes	0	4	4
199	R:R:L264	R:R:T244	2.95	No	Yes	0	4	4
200	R:R:G245	R:R:Q248	1.64	No	Yes	0	6	3
201	R:R:C251	R:R:V247	1.71	No	No	0	4	4
202	R:R:L256	R:R:Q248	7.99	No	Yes	0	5	3
203	R:R:Q248	R:R:Y257	5.64	Yes	No	0	3	4
204	R:R:C251	R:R:C254	7.28	No	No	0	4	4
205	R:R:C254	R:R:L256	1.59	No	No	0	4	5
206	R:R:L260	R:R:V259	1.49	No	No	0	4	1
207	R:R:V259	R:R:Y263	2.52	No	No	0	1	4
208	R:R:E261	R:R:R262	4.65	No	No	0	4	3
209	R:R:V269	R:R:W265	3.68	No	No	0	6	3
210	R:R:G268	R:R:L267	1.71	No	No	0	7	7
211	R:R:N275	R:R:P276	1.63	No	Yes	0	9	9
212	R:R:L277	R:R:Y281	2.34	No	No	0	6	5
213	R:R:I278	R:R:Y279	8.46	Yes	No	0	8	9
214	R:R:I278	R:R:W282	2.35	Yes	No	0	8	7
215	R:R:R287	R:R:Y281	7.2	No	No	0	8	5
216	R:R:Q283	R:R:V286	4.3	No	No	0	8	9
217	R:R:K284	R:R:R287	7.43	No	No	0	5	8
218	R:R:K284	R:R:L288	7.05	No	No	0	5	4
219	R:R:M293	R:R:Q289	4.08	No	No	0	5	7
220	R:R:D102	R:R:S40	1.47	No	No	0	9	8
221	R:R:L169	R:R:T168	1.47	No	No	0	6	4
222	R:R:N22	R:R:T52	1.46	Yes	No	0	9	6
223	R:R:F161	R:R:P140	1.44	No	Yes	0	4	5
224	R:R:Q197	R:R:S196	1.44	No	No	0	5	5
225	R:R:I136	R:R:L169	1.43	No	No	0	6	6
226	R:R:I126	R:R:N46	1.42	No	No	0	7	9
227	R:R:Q74	R:R:T76	1.42	No	No	0	7	2
228	R:R:L14	R:R:L266	1.38	No	No	0	5	5
229	R:R:L17	R:R:L273	1.38	No	No	0	4	5
230	R:R:L24	R:R:L290	1.38	No	No	0	8	5
231	R:R:L32	R:R:L41	1.38	Yes	Yes	0	7	9
232	R:R:L256	R:R:L260	1.38	No	No	0	5	4
233	R:R:L274	R:R:L277	1.38	No	No	0	5	6
234	R:R:L41	R:R:N36	1.37	Yes	No	0	9	9
235	R:R:L105	R:R:Q109	1.33	No	No	0	5	5
236	R:R:F120	R:R:S118	1.32	No	No	0	3	8
237	R:R:H292	R:R:M293	1.31	No	No	0	5	5
238	R:R:H255	R:R:L258	1.29	No	No	0	2	1
239	R:R:F138	R:R:L80	1.22	Yes	No	0	4	5
240	R:R:Q109	R:R:R112	1.17	No	No	0	5	5
241	L:L:?1	R:R:A90	1	Yes	No	0	0	7
242	R:R:R287	R:R:W282	1	No	No	0	8	7
243	L:L:?1	R:R:S156	0.95	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.31867	15	1	0
2	R:R:I18	4.925	4	2	8
3	R:R:N22	4.36	5	2	9
4	R:R:V29	1.9375	4	0	8
5	R:R:L32	2.42	4	0	7
6	R:R:L41	2.13	4	0	9
7	R:R:L47	4.2075	4	2	9
8	R:R:D51	5.544	5	2	9
9	R:R:Y104	6.0675	4	8	8
10	R:R:F138	4.585	4	0	4
11	R:R:P140	2.688	5	3	5
12	R:R:I143	4.67	4	3	4
13	R:R:F157	8.3825	4	1	4
14	R:R:V160	3.3825	4	0	5
15	R:R:F174	4.1875	4	1	8
16	R:R:F181	5.768	5	7	8
17	R:R:F184	5.894	5	0	6
18	R:R:Y185	5.43	5	7	9
19	R:R:W238	5.47143	7	1	8
20	R:R:T244	3.39	4	0	4
21	R:R:Q248	4.6075	4	0	3
22	R:R:P276	2.51	4	0	9
23	R:R:I278	4.245	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W265	26.5835	16.64	Yes	No	0	0	3
2	R:R:V269	R:R:W265	11.5034	3.68	No	No	0	6	3
3	R:R:I58	R:R:W265	15.4434	2.35	No	No	0	7	3
4	L:L:?1	R:R:L94	100	1.76	Yes	No	0	0	5
5	R:R:L129	R:R:L94	99.9814	2.77	No	No	0	6	5
6	R:R:L129	R:R:T95	98.0626	2.95	No	No	0	6	8
7	R:R:L47	R:R:T95	93.6475	4.42	Yes	No	0	9	8
8	R:R:D51	R:R:L47	37.4162	5.43	Yes	Yes	2	9	9
9	R:R:D51	R:R:N22	15.7787	6.73	Yes	Yes	2	9	9
10	R:R:I18	R:R:N22	13.8227	4.25	Yes	Yes	2	8	9
11	R:R:I18	R:R:L273	17.6509	2.85	Yes	No	0	8	5
12	R:R:L17	R:R:L273	13.2638	1.38	No	No	0	4	5
13	R:R:D51	R:R:S272	12.4069	5.89	Yes	No	2	9	9
14	R:R:I18	R:R:S272	10.9817	10.84	Yes	No	2	8	9
15	R:R:A15	R:R:I58	10.4881	3.25	No	No	0	6	7
16	R:R:A15	R:R:S59	10.0503	1.71	No	No	0	6	7
17	R:R:I19	R:R:S59	12.7981	1.55	No	No	0	6	7
18	R:R:G55	R:R:I19	13.18	3.53	No	No	0	8	6
19	R:R:G55	R:R:I18	13.5898	1.76	No	Yes	0	8	8
20	R:R:L47	R:R:N275	33.411	5.49	Yes	No	2	9	9
21	R:R:N275	R:R:P276	33.9605	1.63	No	Yes	0	9	9
22	R:R:P276	R:R:V25	35.3856	1.77	Yes	No	0	9	9
23	R:R:V25	R:R:V29	31.9765	1.6	No	Yes	0	9	8
24	R:R:L41	R:R:V29	21.3022	1.49	Yes	Yes	0	9	8
25	R:R:L32	R:R:L41	15.7135	1.38	Yes	Yes	0	7	9
26	R:R:N46	R:R:T95	32.8335	2.92	No	No	0	9	8
27	R:R:I126	R:R:N46	30.095	1.42	No	No	0	7	9
28	R:R:F43	R:R:I126	26.5928	5.02	No	No	0	8	7
29	R:R:D102	R:R:F43	23.016	5.97	No	No	0	9	8
30	R:R:D102	R:R:Y113	19.3648	5.75	No	No	0	9	9
31	R:R:M117	R:R:Y113	15.639	8.38	No	No	0	7	9
32	R:R:L47	R:R:V96	53.642	1.49	Yes	No	0	9	9
33	R:R:D51	R:R:S92	17.5671	2.94	Yes	No	0	9	9
34	R:R:I54	R:R:S92	13.2638	1.55	No	No	0	8	9
35	R:R:I54	R:R:S88	11.0842	1.55	No	No	0	8	6
36	L:L:?1	R:R:M82	23.1837	2.69	Yes	No	1	0	5
37	R:R:M82	R:R:V160	24.171	3.04	No	Yes	0	5	5
38	R:R:C78	R:R:V160	23.4538	1.71	No	Yes	0	9	5
39	R:R:C155	R:R:C78	10.7023	7.28	No	No	6	9	9
40	R:R:C78	R:R:T73	10.7023	1.69	No	No	6	9	5
41	L:L:?1	R:R:L169	21.0041	3.52	Yes	No	0	0	6
42	R:R:I136	R:R:L169	17.446	1.43	No	No	0	6	6
43	R:R:G137	R:R:I136	13.8133	3.53	No	No	0	7	6
44	R:R:G137	R:R:S87	11.8946	1.86	No	No	0	7	5
45	R:R:F234	R:R:V96	52.1237	3.93	No	No	0	9	9
46	R:R:F181	R:R:F234	50.5868	8.57	Yes	No	0	8	9
47	R:R:F181	R:R:Y185	16.7567	6.19	Yes	Yes	7	8	9
48	R:R:F181	R:R:T100	24.2083	9.08	Yes	No	7	8	8
49	R:R:F184	R:R:T100	22.7552	3.89	Yes	No	0	6	8
50	L:L:?1	R:R:F157	40.3968	18.57	Yes	Yes	1	0	4
51	R:R:F157	R:R:F161	18.6382	5.36	Yes	No	0	4	4
52	R:R:F161	R:R:P140	15.639	1.44	No	Yes	0	4	5
53	R:R:F157	R:R:F158	30.4303	2.14	Yes	No	0	4	3
54	R:R:F158	R:R:Y257	28.7165	4.13	No	No	0	3	4
55	R:R:Q248	R:R:Y257	27.0399	5.64	Yes	No	0	3	4
56	R:R:P163	R:R:Q248	13.2358	3.16	No	Yes	0	3	3
57	L:L:?1	R:R:F241	10.7023	9.29	Yes	No	1	0	6
58	R:R:E261	R:R:F241	13.0123	5.83	No	No	0	4	6
59	R:R:E261	R:R:T244	19.3927	4.23	No	Yes	0	4	4
60	R:R:G245	R:R:T244	10.1434	1.82	No	Yes	0	6	4
61	L:L:?1	R:R:R262	10.9445	6.17	Yes	No	0	0	3
62	L:L:?1	R:R:F174	17.5764	7.74	Yes	Yes	1	0	8
63	R:R:F174	R:R:L242	16.3841	4.87	Yes	No	0	8	6
64	R:R:L242	R:R:S170	14.4001	6.01	No	No	0	6	6
65	L:L:?1	R:R:W238	30.5048	13.02	Yes	Yes	1	0	8
66	R:R:N271	R:R:W238	25.7917	2.26	No	Yes	1	9	8
67	R:R:N271	R:R:S233	24.022	1.49	No	No	0	9	7
68	R:R:I278	R:R:S233	22.1125	3.1	Yes	No	0	8	7
69	R:R:I278	R:R:W282	16.2724	2.35	Yes	No	0	8	7
70	R:R:L256	R:R:Q248	15.3782	7.99	No	Yes	0	5	3
71	R:R:R287	R:R:W282	12.3975	1	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M82	2.69	1	Yes	No	0	5	0	1
L:L:?1	R:R:V85	3.79	1	Yes	No	0	7	0	1
L:L:?1	R:R:T86	3.75	1	Yes	No	0	5	0	1
L:L:?1	R:R:A89	4	1	Yes	No	0	6	0	1
L:L:?1	R:R:V93	1.89	1	Yes	No	0	7	0	1
L:L:?1	R:R:L94	1.76	1	Yes	No	0	5	0	1
L:L:?1	R:R:F157	18.57	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L169	3.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:F174	7.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W238	13.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F241	9.29	1	Yes	No	0	6	0	1
L:L:?1	R:R:R262	6.17	1	Yes	No	0	3	0	1
L:L:?1	R:R:W265	16.64	1	Yes	No	0	3	0	1
R:R:I58	R:R:W265	2.35	0	No	No	7	3	2	1
R:R:F157	R:R:M82	7.46	1	Yes	No	4	5	1	1
R:R:M82	R:R:V160	3.04	1	No	Yes	5	5	1	2
R:R:T86	R:R:V85	1.59	1	No	No	5	7	1	1
R:R:V93	R:R:W238	2.45	1	No	Yes	7	8	1	1
R:R:L129	R:R:L94	2.77	0	No	No	6	5	2	1
R:R:F157	R:R:F158	2.14	1	Yes	No	4	3	1	2
R:R:F157	R:R:F161	5.36	1	Yes	No	4	4	1	2
R:R:F161	R:R:V160	3.93	0	No	Yes	4	5	2	2
R:R:F174	R:R:F175	2.14	1	Yes	No	8	5	1	2
R:R:F174	R:R:W238	2	1	Yes	Yes	8	8	1	1
R:R:F174	R:R:L242	4.87	1	Yes	No	8	6	1	2
R:R:S237	R:R:W238	3.71	1	No	Yes	7	8	2	1
R:R:N271	R:R:S237	8.94	1	No	No	9	7	2	2
R:R:F241	R:R:W238	5.01	1	No	Yes	6	8	1	1
R:R:G268	R:R:W238	9.85	0	No	Yes	7	8	2	1
R:R:N271	R:R:W238	2.26	1	No	Yes	9	8	2	1
R:R:E261	R:R:F241	5.83	0	No	No	4	6	2	1
R:R:E261	R:R:R262	4.65	0	No	No	4	3	2	1
R:R:V269	R:R:W265	3.68	0	No	No	6	3	2	1
R:R:L169	R:R:T168	1.47	0	No	No	6	4	1	2
R:R:I136	R:R:L169	1.43	0	No	No	6	6	2	1
L:L:?1	R:R:A90	1	1	Yes	No	0	7	0	1
L:L:?1	R:R:S156	0.95	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L79_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.49
Number of Linked Nodes	227
Number of Links	243
Number of Hubs	23
Number of Links mediated by Hubs	99
Number of Communities	9
Number of Nodes involved in Communities	41
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	23702
Length Of Smallest Path	3
Average Path Length	11.5388
Length of Longest Path	23
Minimum Path Strength	1.25
Average Path Strength	4.22106
Maximum Path Strength	13.8133
Minimum Path Correlation	0.7
Average Path Correlation	0.944258
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	65.9353
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.0184
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8WL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8WL
Name	N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
Synonyms	AR231453
Identifier
Formula	C21 H24 F N7 O5 S
Molecular Weight	505.523
SMILES
PubChem	24939268
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>9L79_nogp_Chain_R F S F G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Q E C H L Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-		2.82	2024-06-19	To be published
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	9L79	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-12-31	To be published
	9L79 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.98	2025-12-31	To be published
	9L80	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir	chim(NtGi1-Gs)/β1/γ2	3.33	2025-12-31	To be published
	9L80 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir		3.33	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9L79_nogp.zip

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