Code5MV
NameMK-0893
SynonymsMK-0893
Identifier
FormulaC32 H27 Cl2 N3 O4
Molecular Weight588.48
SMILES
PubChem11570626
Formal Charge0
Total Atoms68
Total Chiral Atoms1
Total Bonds72
Total Aromatic Bonds28
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5EE7 B1 Peptide Glucagon Glucagon Homo Sapiens - MK0893 - 2.5 2016-04-20 doi.org/10.1038/nature17414

A 2D representation of the interactions of 5MV in 5EE7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L333 R:R:M338 5.65 2 No Yes 7 5 2 2
R:R:F345 R:R:L333 4.87 2 Yes No 7 7 1 2
R:R:F345 R:R:M338 4.98 2 Yes Yes 7 5 1 2
R:R:F345 R:R:H340 4.53 2 Yes No 7 5 1 2
R:R:R346 R:R:Y343 5.14 2 Yes Yes 8 7 1 2
R:R:E406 R:R:Y343 4.49 2 No Yes 9 7 2 2
R:R:F345 R:R:K349 4.96 2 Yes No 7 9 1 1
R:R:F345 W:W:?1 4.35 2 Yes Yes 7 0 1 0
R:R:K405 R:R:R346 11.14 0 No Yes 6 8 2 1
R:R:E406 R:R:R346 10.47 2 No Yes 9 8 2 1
R:R:R346 W:W:?1 9.93 2 Yes Yes 8 0 1 0
R:R:K349 W:W:?1 18.72 2 No Yes 9 0 1 0
R:R:L399 R:R:S350 7.51 0 No No 8 9 2 1
R:R:S350 R:R:Y400 6.36 0 No Yes 9 8 1 2
R:R:S350 W:W:?1 6.13 0 No Yes 9 0 1 0
R:R:T353 W:W:?1 9.03 0 No Yes 8 0 1 0
R:R:L403 W:W:?1 5.65 0 No Yes 5 0 1 0
R:R:E406 R:R:N404 10.52 2 No No 9 9 2 1
R:R:N404 R:R:V407 8.87 0 No Yes 9 9 1 2
R:R:N404 W:W:?1 4.91 0 No Yes 9 0 1 0
R:R:L403 R:R:Q408 1.33 0 No No 5 7 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.39
Average Nodes In Shell18.00
Average Hubs In Shell7.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.39
Average Nodes In Shell18.00
Average Hubs In Shell7.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell18.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)