psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L303	R:R:T28	7.37	No	No	0	4	5
2	R:R:I29	R:R:I83	4.42	Yes	No	0	5	6
3	R:R:I29	R:R:S86	4.64	Yes	No	0	5	4
4	R:R:I29	R:R:I87	7.36	Yes	No	0	5	5
5	R:R:I83	R:R:V32	4.61	No	No	0	6	7
6	R:R:V32	R:R:Y310	6.31	No	Yes	0	7	7
7	R:R:I35	R:R:L311	8.56	No	No	0	7	5
8	R:R:C36	R:R:Y310	4.03	No	Yes	0	6	7
9	R:R:I40	R:R:L72	4.28	Yes	No	0	6	7
10	R:R:D71	R:R:N43	12.12	No	No	4	9	9
11	R:R:L72	R:R:N43	15.1	No	No	0	7	9
12	R:R:N43	R:R:P317	8.15	No	No	4	9	9
13	R:R:F331	R:R:M45	4.98	No	No	0	7	7
14	R:R:N321	R:R:V46	8.87	No	No	5	7	9
15	R:R:F327	R:R:V46	5.24	Yes	No	5	8	9
16	R:R:M51	R:R:V47	4.56	No	No	0	4	7
17	R:R:F327	R:R:V49	9.18	Yes	No	0	8	8
18	R:R:M56	R:R:V50	6.09	Yes	No	0	8	8
19	R:R:V50	R:R:V65	4.81	No	No	0	8	6
20	R:R:M51	R:R:R52	3.72	No	No	0	4	5
21	R:R:M56	R:R:T53	6.02	Yes	No	0	8	6
22	R:R:K333	R:R:T53	9.01	No	No	0	4	6
23	R:R:H55	R:R:K326	3.93	No	No	0	5	6
24	R:R:M56	R:R:N61	15.43	Yes	No	6	8	9
25	R:R:K326	R:R:M56	4.32	No	Yes	6	6	8
26	R:R:F139	R:R:R57	10.69	No	No	0	3	8
27	R:R:P59	R:R:T58	5.25	No	No	0	6	7
28	R:R:N61	R:R:T58	10.24	No	No	0	9	7
29	R:R:E122	R:R:P59	4.72	No	No	0	8	6
30	R:R:F119	R:R:T60	6.49	Yes	No	0	9	9
31	R:R:K326	R:R:N61	6.99	No	No	6	6	9
32	R:R:C62	R:R:F139	4.19	No	No	0	4	3
33	R:R:C62	R:R:I146	4.91	No	No	0	4	7
34	R:R:F119	R:R:Y63	6.19	Yes	Yes	0	9	8
35	R:R:E122	R:R:Y63	13.47	No	Yes	0	8	8
36	R:R:A142	R:R:Y63	5.34	No	Yes	0	7	8
37	R:R:I145	R:R:Y63	10.88	No	Yes	0	6	8
38	R:R:F119	R:R:L64	7.31	Yes	No	0	9	8
39	R:R:L64	R:R:N321	9.61	No	No	0	8	7
40	R:R:S115	R:R:S66	4.89	No	No	0	8	9
41	R:R:I146	R:R:S66	6.19	No	No	0	7	9
42	R:R:S66	R:R:W150	6.18	No	Yes	0	9	9
43	R:R:L67	R:R:S115	6.01	Yes	No	0	9	8
44	R:R:I116	R:R:L67	7.14	No	Yes	0	8	9
45	R:R:L67	R:R:N316	5.49	Yes	No	0	9	9
46	R:R:V69	R:R:W150	3.68	No	Yes	0	7	9
47	R:R:D71	R:R:P317	4.83	No	No	4	9	9
48	R:R:L107	R:R:M73	4.24	No	No	0	5	6
49	R:R:G108	R:R:V74	3.68	No	No	0	7	7
50	R:R:I109	R:R:V74	9.22	Yes	No	0	7	7
51	R:R:L75	R:R:S313	7.51	No	No	0	7	9
52	R:R:A78	R:R:Q105	6.06	No	No	1	7	7
53	R:R:A78	R:R:Y310	4	No	Yes	1	7	7
54	L:L:?3	R:R:A78	4.34	Yes	No	1	0	7
55	R:R:G79	R:R:Y310	4.35	No	Yes	0	7	7
56	R:R:P81	R:R:Y93	4.17	No	Yes	3	5	6
57	R:R:I101	R:R:P81	5.08	No	No	3	5	5
58	R:R:N82	R:R:S86	4.47	No	No	0	6	4
59	R:R:N82	R:R:R306	8.44	No	No	1	6	5
60	R:R:N82	R:R:Y310	5.81	No	Yes	1	6	7
61	R:R:T84	R:R:Y88	3.75	No	No	0	4	5
62	R:R:T84	R:R:Y93	9.99	No	Yes	0	4	6
63	R:R:D85	R:R:W91	8.93	No	Yes	0	4	8
64	R:R:I87	R:R:Y88	6.04	No	No	0	5	5
65	R:R:W91	R:R:Y93	4.82	Yes	Yes	3	8	6
66	R:R:C98	R:R:W91	3.92	No	Yes	0	9	8
67	R:R:I101	R:R:W91	5.87	No	Yes	3	5	8
68	R:R:C179	R:R:W91	15.67	No	Yes	0	9	8
69	R:R:I101	R:R:Y93	4.84	No	Yes	3	5	6
70	R:R:L99	R:R:Y95	11.72	No	No	0	5	3
71	R:R:D165	R:R:Y95	12.64	No	No	0	5	3
72	R:R:C98	R:R:L166	7.94	No	No	0	9	4
73	R:R:L164	R:R:L99	4.15	No	No	0	5	5
74	R:R:T102	R:R:Y106	4.99	No	Yes	1	4	5
75	R:R:L164	R:R:T102	7.37	No	No	0	5	4
76	L:L:H2	R:R:T102	9.58	Yes	No	1	0	4
77	R:R:C157	R:R:Y103	9.41	No	Yes	0	7	6
78	R:R:M158	R:R:Y103	9.58	No	Yes	0	4	6
79	R:R:F161	R:R:Y103	17.54	No	Yes	0	5	6
80	L:L:?3	R:R:Q105	13.45	Yes	No	1	0	7
81	R:R:W160	R:R:Y106	36.66	Yes	Yes	1	5	5
82	R:R:Y106	R:R:Y181	3.97	Yes	Yes	1	5	4
83	R:R:Y106	R:R:Y192	3.97	Yes	Yes	1	5	5
84	L:L:H2	R:R:Y106	7.62	Yes	Yes	1	0	5
85	L:L:?3	R:R:Y106	6.46	Yes	Yes	1	0	5
86	R:R:L107	R:R:S154	4.5	No	No	0	5	4
87	R:R:I109	R:R:W279	4.7	Yes	Yes	1	7	8
88	R:R:I109	R:R:R283	3.76	Yes	Yes	1	7	6
89	L:L:?3	R:R:I109	3.93	Yes	Yes	1	0	7
90	R:R:N110	R:R:T153	4.39	No	No	0	6	8
91	R:R:N110	R:R:Y156	5.81	No	No	2	6	5
92	R:R:F199	R:R:N110	6.04	Yes	No	2	5	6
93	R:R:A111	R:R:W150	3.89	No	Yes	0	7	9
94	R:R:F199	R:R:S113	3.96	Yes	No	0	5	7
95	R:R:F275	R:R:I116	6.28	No	No	0	9	8
96	R:R:I116	R:R:Y320	7.25	No	No	0	8	9
97	R:R:F119	R:R:R123	14.97	Yes	No	0	9	9
98	R:R:T120	R:R:Y211	7.49	No	Yes	0	8	9
99	R:R:C137	R:R:E122	9.12	No	No	0	7	8
100	R:R:R123	R:R:Y211	9.26	No	Yes	0	9	9
101	R:R:R123	R:R:Y320	6.17	No	No	0	9	9
102	R:R:C128	R:R:Y124	6.72	No	Yes	7	7	8
103	R:R:H129	R:R:Y124	10.89	Yes	Yes	7	6	8
104	R:R:L210	R:R:Y124	11.72	No	Yes	0	7	8
105	R:R:I127	R:R:I214	14.72	No	No	0	9	9
106	R:R:C128	R:R:H129	4.42	No	Yes	7	7	6
107	R:R:C128	R:R:I217	4.91	No	No	0	7	6
108	R:R:F135	R:R:I131	3.77	No	No	0	4	7
109	R:R:F135	R:R:Q134	4.68	No	No	0	4	6
110	R:R:L136	R:R:R141	15.79	No	Yes	0	4	5
111	R:R:S140	R:R:T138	4.8	No	No	0	4	8
112	R:R:F139	R:R:K143	14.89	No	No	0	3	4
113	R:R:K144	R:R:R141	3.71	No	Yes	0	3	5
114	R:R:I145	R:R:R141	7.52	No	Yes	0	6	5
115	R:R:I146	R:R:I147	4.42	No	No	0	7	3
116	R:R:M194	R:R:Y156	8.38	No	No	2	5	5
117	R:R:F199	R:R:Y156	14.44	Yes	No	2	5	5
118	R:R:C157	R:R:W160	5.22	No	Yes	0	7	5
119	R:R:W160	R:R:Y192	7.72	Yes	Yes	1	5	5
120	R:R:L163	R:R:Y188	5.86	No	No	0	4	5
121	R:R:I177	R:R:L166	5.71	No	No	0	4	4
122	R:R:I177	R:R:N167	5.66	No	No	0	4	1
123	L:L:H2	R:R:C179	7.37	Yes	No	0	0	9
124	R:R:R185	R:R:Y181	7.2	Yes	Yes	1	2	4
125	R:R:Y181	R:R:Y188	16.88	Yes	No	0	4	5
126	R:R:Y181	R:R:Y192	10.92	Yes	Yes	1	4	5
127	L:L:?1	R:R:Y181	5.02	Yes	Yes	1	0	4
128	L:L:H2	R:R:Y181	5.44	Yes	Yes	1	0	4
129	R:R:I183	R:R:K182	5.82	No	No	0	2	4
130	R:R:I183	R:R:Y187	7.25	No	No	0	2	1
131	R:R:I183	R:R:Y188	4.84	No	No	0	2	5
132	R:R:S184	R:R:Y187	3.82	No	No	0	4	1
133	R:R:R185	R:R:Y192	7.2	Yes	Yes	1	2	5
134	L:L:?1	R:R:R185	11.7	Yes	Yes	1	0	2
135	R:R:P190	R:R:S189	5.34	No	No	0	4	3
136	R:R:V286	R:R:Y192	11.36	No	Yes	1	6	5
137	L:L:?1	R:R:Y192	3.76	Yes	Yes	1	0	5
138	R:R:M194	R:R:V198	4.56	No	No	2	5	5
139	R:R:F199	R:R:M194	3.73	Yes	No	2	5	5
140	R:R:D195	R:R:R283	14.29	No	Yes	0	6	6
141	R:R:F196	R:R:Y200	10.32	No	Yes	0	6	8
142	R:R:F196	R:R:V201	3.93	No	No	0	6	5
143	R:R:F196	R:R:V287	5.24	No	No	0	6	6
144	R:R:F199	R:R:V198	5.24	Yes	No	2	5	5
145	R:R:V198	R:R:V202	4.81	No	No	0	5	5
146	R:R:M280	R:R:Y200	8.38	No	Yes	0	6	8
147	R:R:R283	R:R:Y200	14.4	Yes	Yes	0	6	8
148	R:R:F213	R:R:V209	7.87	No	No	0	5	5
149	R:R:L268	R:R:Y211	12.89	No	Yes	0	8	9
150	R:R:V272	R:R:Y211	5.05	No	Yes	0	8	9
151	R:R:F213	R:R:R216	7.48	No	No	0	5	4
152	R:R:L218	R:R:R261	4.86	No	Yes	0	8	7
153	R:R:F219	R:R:T265	9.08	No	No	0	5	8
154	R:R:K262	R:R:R261	13.61	No	Yes	0	5	7
155	R:R:K266	R:R:M267	7.2	No	No	0	7	9
156	R:R:K266	R:R:V270	6.07	No	No	0	7	7
157	R:R:I319	R:R:V271	7.68	No	No	0	8	8
158	R:R:V271	R:R:Y320	6.31	No	No	0	8	9
159	R:R:F275	R:R:W279	20.04	No	Yes	0	9	8
160	R:R:L278	R:R:N312	10.98	No	No	0	8	9
161	R:R:R283	R:R:W279	8	Yes	Yes	1	6	8
162	R:R:N312	R:R:W279	15.82	No	Yes	0	9	8
163	R:R:M280	R:R:T284	6.02	No	No	0	6	6
164	R:R:V286	R:R:Y282	8.83	No	Yes	1	6	5
165	R:R:C305	R:R:Y282	4.03	No	Yes	0	5	5
166	R:R:I309	R:R:Y282	7.25	No	Yes	1	6	5
167	L:L:?1	R:R:Y282	6.27	Yes	Yes	1	0	5
168	L:L:?3	R:R:Y282	15.08	Yes	Yes	1	0	5
169	R:R:L285	R:R:N289	9.61	No	Yes	0	4	4
170	L:L:?1	R:R:V286	7.97	Yes	No	1	0	6
171	R:R:F296	R:R:N289	4.83	No	Yes	0	1	4
172	L:L:?1	R:R:N289	10.28	Yes	Yes	0	0	4
173	R:R:F291	R:R:S290	3.96	No	No	0	5	4
174	R:R:E298	R:R:F296	10.49	No	No	0	3	1
175	R:R:F296	R:R:F301	7.5	No	No	0	1	4
176	R:R:E298	R:R:W300	4.36	No	No	0	3	2
177	R:R:F301	R:R:W300	4.01	No	No	0	4	2
178	L:L:?1	R:R:L302	5.92	Yes	No	0	0	4
179	R:R:I307	R:R:L303	7.14	No	No	0	5	4
180	R:R:C308	R:R:F304	8.38	No	No	0	7	4
181	R:R:R306	R:R:Y310	7.2	No	Yes	1	5	7
182	L:L:?3	R:R:R306	12.28	Yes	No	1	0	5
183	L:L:?3	R:R:I309	7.87	Yes	No	1	0	6
184	R:R:N312	R:R:N316	8.17	No	No	0	9	9
185	R:R:L322	R:R:V318	4.47	No	No	0	5	7
186	R:R:F327	R:R:N321	8.46	Yes	No	5	8	7
187	R:R:F327	R:R:L322	7.31	Yes	No	0	8	5
188	R:R:K333	R:R:L334	4.23	No	No	0	4	6
189	L:L:?1	L:L:H2	4.13	Yes	Yes	1	0	0
190	L:L:?3	L:L:H2	4.73	Yes	Yes	1	0	0
191	R:R:N221	R:R:R261	3.62	No	Yes	0	7	7
192	R:R:M204	R:R:Y200	3.59	No	Yes	0	6	8
193	R:R:D195	R:R:F199	3.58	No	Yes	0	6	5
194	R:R:P295	R:R:S294	3.56	No	No	0	1	2
195	R:R:P203	R:R:V202	3.53	No	No	0	9	5
196	R:R:L75	R:R:Y310	3.52	No	Yes	0	7	7
197	R:R:L107	R:R:Y103	3.52	No	Yes	0	5	6
198	R:R:I191	R:R:W160	3.52	No	Yes	0	7	5
199	R:R:P203	R:R:T117	3.5	No	No	0	9	7
200	R:R:C114	R:R:T153	3.38	No	No	0	5	8
201	R:R:A207	R:R:T120	3.36	No	No	0	8	8
202	R:R:A215	R:R:T265	3.36	No	No	0	7	8
203	R:R:M280	R:R:P281	3.35	No	No	0	6	9
204	R:R:C137	R:R:I125	3.27	No	No	0	7	4
205	R:R:S189	R:R:S290	3.26	No	No	0	3	4
206	R:R:S290	R:R:V287	3.23	No	No	0	4	6
207	R:R:C100	R:R:L104	3.17	No	No	0	4	4
208	R:R:T208	R:R:V272	3.17	No	No	0	5	8
209	R:R:C308	R:R:L278	3.17	No	No	0	7	8
210	R:R:P295	R:R:Q297	3.16	No	No	0	1	3
211	R:R:F213	R:R:Y124	3.09	No	Yes	0	5	8
212	R:R:I29	R:R:V26	3.07	Yes	No	0	5	5
213	R:R:I40	R:R:V76	3.07	Yes	No	0	6	4
214	R:R:L67	R:R:S112	3	Yes	No	0	9	9
215	R:R:L31	R:R:V27	2.98	No	No	0	4	5
216	R:R:L80	R:R:V76	2.98	No	No	0	8	4
217	R:R:L206	R:R:V202	2.98	No	No	0	6	5
218	R:R:L218	R:R:V264	2.98	No	No	0	8	8
219	R:R:L268	R:R:V264	2.98	No	No	0	8	8
220	R:R:L274	R:R:V270	2.98	No	No	0	6	7
221	R:R:N289	R:R:V288	2.96	Yes	No	0	4	4
222	R:R:L210	R:R:T120	2.95	No	No	0	7	8
223	R:R:I40	R:R:I44	2.94	Yes	No	0	6	5
224	R:R:D71	R:R:S313	2.94	No	No	0	9	9
225	R:R:I121	R:R:I125	2.94	No	No	0	6	4
226	R:R:M267	R:R:M323	2.89	No	No	0	9	8
227	R:R:P295	R:R:R185	2.88	No	Yes	0	1	2
228	R:R:I34	R:R:L38	2.85	No	No	0	4	5
229	R:R:I44	R:R:L48	2.85	No	No	0	5	5
230	R:R:I214	R:R:L218	2.85	No	No	0	9	8
231	R:R:I214	R:R:L268	2.85	No	No	0	9	8
232	R:R:I273	R:R:L277	2.85	No	No	0	5	5
233	R:R:I315	R:R:L274	2.85	No	No	0	6	6
234	R:R:I307	R:R:L311	2.85	No	No	0	5	5
235	R:R:C335	R:R:F331	2.79	No	No	0	6	7
236	R:R:A118	R:R:Y63	2.67	No	Yes	0	7	8
237	R:R:H129	R:R:K132	2.62	Yes	No	0	6	5
238	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
239	R:R:F148	R:R:K144	2.48	No	No	0	3	3
240	R:R:M323	R:R:R328	2.48	No	No	0	8	9
241	R:R:I35	R:R:Y310	2.42	No	Yes	0	7	7
242	R:R:F161	R:R:F162	2.14	No	No	0	5	5
243	R:R:A314	R:R:G39	1.95	No	No	0	8	8
244	R:R:G42	R:R:V41	1.84	No	No	0	8	4
245	R:R:G97	R:R:V96	1.84	No	No	0	5	2
246	R:R:G197	R:R:V201	1.84	No	No	0	4	5
247	R:R:A133	R:R:C137	1.81	No	No	0	7	7
248	R:R:A126	R:R:A133	1.79	No	No	0	8	7
249	R:R:G37	R:R:I40	1.76	No	Yes	0	5	6
250	R:R:G39	R:R:L38	1.71	No	No	0	8	5
251	R:R:G39	R:R:L75	1.71	No	No	0	8	7
252	R:R:C114	R:R:V149	1.71	No	No	0	5	7
253	R:R:A68	R:R:V46	1.7	No	No	0	9	9
254	R:R:A68	R:R:V47	1.7	No	No	0	9	7
255	R:R:A330	R:R:V49	1.7	No	No	0	7	8
256	R:R:D85	R:R:G89	1.68	No	No	0	4	4
257	R:R:A276	R:R:M204	1.61	No	No	0	6	6
258	R:R:T28	R:R:V27	1.59	No	No	0	5	5
259	L:L:H2	R:R:G180	1.59	Yes	No	0	0	3
260	R:R:A77	R:R:L104	1.58	No	No	0	5	4
261	R:R:I177	R:R:S90	1.55	No	No	0	4	5
262	R:R:I205	R:R:V201	1.54	No	No	0	4	5
263	R:R:I205	R:R:V209	1.54	No	No	0	4	5
264	R:R:I319	R:R:V270	1.54	No	No	0	8	7
265	R:R:H129	R:R:P130	1.53	Yes	No	0	6	8
266	R:R:M45	R:R:V41	1.52	No	No	0	7	4
267	R:R:A77	R:R:Q105	1.52	No	No	0	5	7
268	R:R:N167	R:R:S178	1.49	No	No	0	1	4
269	R:R:N186	R:R:S189	1.49	No	No	0	2	3
270	R:R:L292	R:R:V288	1.49	No	No	0	4	4
271	R:R:G97	R:R:Y93	1.45	No	Yes	0	5	6
272	R:R:I83	R:R:L33	1.43	No	No	0	6	3
273	R:R:Q263	R:R:V264	1.43	No	No	0	8	8
274	R:R:K333	R:R:N336	1.4	No	No	0	4	4
275	R:R:R141	R:R:T138	1.29	Yes	No	0	5	8
276	R:R:F148	R:R:F152	1.07	No	No	0	3	3
277	R:R:F219	R:R:R261	1.07	No	Yes	0	5	7
278	R:R:F327	R:R:F331	1.07	Yes	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I29	4.8725	4	0	5
2	R:R:I40	3.0125	4	0	6
3	R:R:M56	7.965	4	6	8
4	R:R:Y63	7.71	5	0	8
5	R:R:L67	5.41	4	0	9
6	R:R:W91	7.842	5	3	8
7	R:R:Y93	5.054	5	3	6
8	R:R:Y103	10.0125	4	0	6
9	R:R:Y106	10.6117	6	1	5
10	R:R:I109	5.4025	4	1	7
11	R:R:F119	8.74	4	0	9
12	R:R:Y124	8.105	4	7	8
13	R:R:H129	4.865	4	7	6
14	R:R:R141	7.0775	4	0	5
15	R:R:W150	4.085	4	0	9
16	R:R:W160	13.28	4	1	5
17	R:R:Y181	8.23833	6	1	4
18	R:R:R185	7.245	4	1	2
19	R:R:Y192	7.48833	6	1	5
20	R:R:F199	6.165	6	2	5
21	R:R:Y200	9.1725	4	0	8
22	R:R:Y211	8.6725	4	0	9
23	R:R:R261	5.79	4	0	7
24	R:R:W279	12.14	4	1	8
25	R:R:Y282	8.292	5	1	5
26	R:R:R283	10.1125	4	1	6
27	R:R:N289	6.92	4	0	4
28	R:R:Y310	4.705	8	1	7
29	R:R:F327	6.252	5	5	8
30	L:L:?1	6.88125	8	1	0
31	L:L:H2	5.78	7	1	0
32	L:L:?3	8.5175	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I35	R:R:Y310	14.3787	2.42	No	Yes	0	7	7
2	R:R:I35	R:R:L311	12.3458	8.56	No	No	0	7	5
3	R:R:I307	R:R:L311	10.3057	2.85	No	No	0	5	5
4	R:R:I40	R:R:L72	12.3458	4.28	Yes	No	0	6	7
5	R:R:L72	R:R:N43	14.3787	15.1	No	No	0	7	9
6	R:R:D71	R:R:N43	16.3755	12.12	No	No	4	9	9
7	R:R:D71	R:R:S313	20.4341	2.94	No	No	0	9	9
8	R:R:L75	R:R:S313	22.4381	7.51	No	No	0	7	9
9	R:R:L75	R:R:Y310	32.3494	3.52	No	Yes	0	7	7
10	R:R:F327	R:R:N321	10.87	8.46	Yes	No	5	8	7
11	R:R:L64	R:R:N321	17.3919	9.61	No	No	0	8	7
12	R:R:F119	R:R:L64	18.3397	7.31	Yes	No	0	9	8
13	R:R:F119	R:R:R123	46.9054	14.97	Yes	No	0	9	9
14	R:R:R123	R:R:Y320	63.6752	6.17	No	No	0	9	9
15	R:R:I116	R:R:Y320	69.0324	7.25	No	No	0	8	9
16	R:R:F275	R:R:I116	73.7963	6.28	No	No	0	9	8
17	R:R:F275	R:R:W279	74.187	20.04	No	Yes	0	9	8
18	R:R:I109	R:R:W279	74.5379	4.7	Yes	Yes	1	7	8
19	L:L:?3	R:R:I109	100	3.93	Yes	Yes	1	0	7
20	L:L:?3	R:R:A78	28.526	4.34	Yes	No	1	0	7
21	R:R:A78	R:R:Y310	28.2727	4	No	Yes	1	7	7
22	L:L:?3	R:R:R306	33.6517	12.28	Yes	No	1	0	5
23	R:R:R306	R:R:Y310	27.6723	7.2	No	Yes	1	5	7
24	R:R:F119	R:R:Y63	30.3201	6.19	Yes	Yes	0	9	8
25	R:R:E122	R:R:Y63	19.5225	13.47	No	Yes	0	8	8
26	R:R:E122	R:R:P59	13.2284	4.72	No	No	0	8	6
27	R:R:P59	R:R:T58	12.1324	5.25	No	No	0	6	7
28	R:R:N61	R:R:T58	11.0219	10.24	No	No	0	9	7
29	R:R:I146	R:R:S66	11.4126	6.19	No	No	0	7	9
30	R:R:S115	R:R:S66	20.7271	4.89	No	No	0	8	9
31	R:R:L67	R:R:S115	22.5683	6.01	Yes	No	0	9	8
32	R:R:I116	R:R:L67	17.0483	7.14	No	Yes	0	8	9
33	R:R:L67	R:R:N316	12.4905	5.49	Yes	No	0	9	9
34	R:R:N312	R:R:N316	12.8812	8.17	No	No	0	9	9
35	R:R:N312	R:R:W279	15.8184	15.82	No	Yes	0	9	8
36	L:L:?3	R:R:Y106	26.4388	6.46	Yes	Yes	1	0	5
37	L:L:?3	L:L:H2	41.2805	4.73	Yes	Yes	1	0	0
38	L:L:H2	R:R:C179	17.439	7.37	Yes	No	0	0	9
39	R:R:C179	R:R:W91	16.6142	15.67	No	Yes	0	9	8
40	L:L:H2	R:R:Y181	10.0995	5.44	Yes	Yes	1	0	4
41	R:R:I109	R:R:R283	25.3102	3.76	Yes	Yes	1	7	6
42	R:R:D195	R:R:R283	16.2163	14.29	No	Yes	0	6	6
43	R:R:D195	R:R:F199	15.095	3.58	No	Yes	0	6	5
44	R:R:R123	R:R:Y211	28.6598	9.26	No	Yes	0	9	9
45	R:R:F196	R:R:V201	10.7397	3.93	No	No	0	6	5
46	R:R:F196	R:R:Y200	17.7609	10.32	No	Yes	0	6	8
47	R:R:R283	R:R:Y200	24.0116	14.4	Yes	Yes	0	6	8
48	R:R:I214	R:R:L268	10.2478	2.85	No	No	0	9	8
49	R:R:L268	R:R:Y211	21.1973	12.89	No	Yes	0	8	9
50	R:R:Y181	R:R:Y188	11.5428	16.88	Yes	No	0	4	5
51	L:L:?3	R:R:Y282	15.1167	15.08	Yes	Yes	1	0	5
52	L:L:?1	R:R:Y282	12.8631	6.27	Yes	Yes	1	0	5
53	L:L:?1	L:L:H2	14.064	4.13	Yes	Yes	1	0	0
54	R:R:L268	R:R:V264	10.0814	2.98	No	No	0	8	8
55	R:R:L218	R:R:R261	13.7783	4.86	No	Yes	0	8	7
56	R:R:V271	R:R:Y320	10.1176	6.31	No	No	0	8	9
57	L:L:?1	R:R:N289	16.8023	10.28	Yes	Yes	0	0	4
58	R:R:P295	R:R:R185	13.7131	2.88	No	Yes	0	1	2
59	R:R:R283	R:R:W279	13.1271	8	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I109	R:R:V74	9.22	1	Yes	No	7	7	1	2
R:R:A78	R:R:Q105	6.06	1	No	No	7	7	1	1
R:R:A78	R:R:Y310	4	1	No	Yes	7	7	1	2
L:L:?3	R:R:A78	4.34	1	Yes	No	0	7	0	1
R:R:N82	R:R:R306	8.44	1	No	No	6	5	2	1
R:R:N82	R:R:Y310	5.81	1	No	Yes	6	7	2	2
R:R:C179	R:R:W91	15.67	0	No	Yes	9	8	1	2
R:R:T102	R:R:Y106	4.99	1	No	Yes	4	5	1	1
R:R:L164	R:R:T102	7.37	0	No	No	5	4	2	1
L:L:H2	R:R:T102	9.58	1	Yes	No	0	4	0	1
L:L:?3	R:R:Q105	13.45	1	Yes	No	0	7	0	1
R:R:W160	R:R:Y106	36.66	1	Yes	Yes	5	5	2	1
R:R:Y106	R:R:Y181	3.97	1	Yes	Yes	5	4	1	1
R:R:Y106	R:R:Y192	3.97	1	Yes	Yes	5	5	1	1
L:L:H2	R:R:Y106	7.62	1	Yes	Yes	0	5	0	1
L:L:?3	R:R:Y106	6.46	1	Yes	Yes	0	5	0	1
R:R:I109	R:R:W279	4.7	1	Yes	Yes	7	8	1	2
R:R:I109	R:R:R283	3.76	1	Yes	Yes	7	6	1	2
L:L:?3	R:R:I109	3.93	1	Yes	Yes	0	7	0	1
R:R:W160	R:R:Y192	7.72	1	Yes	Yes	5	5	2	1
L:L:H2	R:R:C179	7.37	1	Yes	No	0	9	0	1
R:R:R185	R:R:Y181	7.2	1	Yes	Yes	2	4	1	1
R:R:Y181	R:R:Y188	16.88	1	Yes	No	4	5	1	2
R:R:Y181	R:R:Y192	10.92	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:Y181	5.02	1	Yes	Yes	0	4	0	1
L:L:H2	R:R:Y181	5.44	1	Yes	Yes	0	4	0	1
R:R:R185	R:R:Y192	7.2	1	Yes	Yes	2	5	1	1
L:L:?1	R:R:R185	11.7	1	Yes	Yes	0	2	0	1
R:R:V286	R:R:Y192	11.36	1	No	Yes	6	5	1	1
L:L:?1	R:R:Y192	3.76	1	Yes	Yes	0	5	0	1
R:R:R283	R:R:W279	8	1	Yes	Yes	6	8	2	2
R:R:V286	R:R:Y282	8.83	1	No	Yes	6	5	1	1
R:R:C305	R:R:Y282	4.03	0	No	Yes	5	5	2	1
R:R:I309	R:R:Y282	7.25	1	No	Yes	6	5	1	1
L:L:?1	R:R:Y282	6.27	1	Yes	Yes	0	5	0	1
L:L:?3	R:R:Y282	15.08	1	Yes	Yes	0	5	0	1
R:R:L285	R:R:N289	9.61	0	No	Yes	4	4	2	1
L:L:?1	R:R:V286	7.97	1	Yes	No	0	6	0	1
R:R:F296	R:R:N289	4.83	0	No	Yes	1	4	2	1
L:L:?1	R:R:N289	10.28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L302	5.92	1	Yes	No	0	4	0	1
R:R:R306	R:R:Y310	7.2	1	No	Yes	5	7	1	2
L:L:?3	R:R:R306	12.28	1	Yes	No	0	5	0	1
L:L:?3	R:R:I309	7.87	1	Yes	No	0	6	0	1
R:R:N289	R:R:V288	2.96	0	Yes	No	4	4	1	2
R:R:P295	R:R:R185	2.88	0	No	Yes	1	2	2	1
L:L:H2	R:R:G180	1.59	1	Yes	No	0	3	0	1
R:R:A77	R:R:Q105	1.52	0	No	No	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WKD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.68
Number of Linked Nodes	249
Number of Links	278
Number of Hubs	32
Number of Links mediated by Hubs	130
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	49577
Length Of Smallest Path	3
Average Path Length	12.675
Length of Longest Path	27
Minimum Path Strength	1.54
Average Path Strength	7.29135
Maximum Path Strength	20.94
Minimum Path Correlation	0.7
Average Path Correlation	0.916578
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	45.1845
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2766
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	LPD
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	LPD
Name	L-PROLINAMIDE
Synonyms
Identifier
Formula	C5 H10 N2 O
Molecular Weight	114.146
SMILES
PubChem	111306
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34981
Sequence	>7WKD_nogp_Chain_R V V T I L L V L I I C G L G I V G N I M V V L V V M R T K H M R T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G S W V Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H P I K A Q F L C T F S R A K K I I I F V W A F T S L Y C M L W F F L L D L N I S C G Y K I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L S S P F Q E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R A A F R K L C N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW9	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.7	2022-12-28	doi.org/10.1038/s41421-022-00477-0
	7XW9 (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		2.7	2022-12-28	doi.org/10.1038/s41421-022-00477-0
	7WKD	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2022-06-15	doi.org/10.1038/s41422-022-00641-x
	7WKD (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.01	2022-06-15	doi.org/10.1038/s41422-022-00641-x
	7X1T	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1T (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-		3.26	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1U	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.19	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1U (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.19	2022-08-31	doi.org/10.1038/s41422-022-00646-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WKD_nogp.zip

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