psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I61	R:R:L112	5.71	No	No	0	7	6
2	R:R:I61	R:R:W367	8.22	No	Yes	0	7	7
3	R:R:M108	R:R:V64	3.04	Yes	No	0	8	7
4	R:R:V371	R:R:V64	3.21	No	No	0	5	7
5	R:R:I65	R:R:M108	5.83	No	Yes	0	6	8
6	R:R:I65	R:R:P109	3.39	No	No	0	6	9
7	R:R:I66	R:R:P67	3.39	No	No	0	4	4
8	R:R:N72	R:R:T68	2.92	Yes	No	0	9	8
9	R:R:G374	R:R:T68	3.64	No	No	0	7	8
10	R:R:I69	R:R:L101	2.85	No	No	0	7	7
11	R:R:I69	R:R:L105	2.85	No	No	0	7	5
12	R:R:D100	R:R:N72	4.04	Yes	Yes	0	9	9
13	R:R:L101	R:R:N72	6.87	No	Yes	0	7	9
14	R:R:N72	R:R:P377	9.77	Yes	No	0	9	9
15	R:R:L101	R:R:T73	2.95	No	No	0	7	4
16	R:R:F391	R:R:L74	6.09	No	No	0	7	7
17	R:R:I395	R:R:L74	4.28	Yes	No	0	6	7
18	R:R:T381	R:R:V75	4.76	No	No	0	7	9
19	R:R:I76	R:R:M94	2.92	No	No	0	7	7
20	R:R:I395	R:R:L77	4.28	Yes	No	0	6	4
21	R:R:M94	R:R:V79	6.09	No	No	0	7	8
22	R:R:I395	R:R:L81	5.71	Yes	No	0	6	4
23	R:R:A390	R:R:E82	6.03	No	No	0	7	7
24	R:R:K83	R:R:Q86	4.07	No	No	0	7	8
25	R:R:L85	R:R:T386	5.9	No	No	0	8	7
26	R:R:F387	R:R:L85	14.61	Yes	No	0	9	8
27	R:R:N90	R:R:Y87	15.12	No	No	0	9	7
28	R:R:A88	R:R:N167	4.69	No	No	0	6	7
29	R:R:F387	R:R:N90	6.04	Yes	No	0	9	9
30	R:R:R169	R:R:Y91	13.38	Yes	No	0	4	5
31	R:R:F92	R:R:H145	5.66	No	Yes	0	8	8
32	R:R:F92	R:R:K175	3.72	No	No	0	8	6
33	R:R:H145	R:R:S95	8.37	Yes	No	2	8	9
34	R:R:I176	R:R:S95	9.29	No	No	2	7	9
35	R:R:S95	R:R:W180	6.18	No	Yes	2	9	9
36	R:R:D100	R:R:L96	4.07	Yes	No	0	9	9
37	R:R:H145	R:R:L96	9	Yes	No	0	8	9
38	R:R:D100	R:R:S142	5.89	Yes	No	0	9	9
39	R:R:D100	R:R:S373	8.83	Yes	No	0	9	9
40	R:R:D100	R:R:N376	8.08	Yes	No	0	9	9
41	R:R:F106	R:R:L102	3.65	No	No	0	5	7
42	R:R:F138	R:R:L102	9.74	Yes	No	0	6	7
43	R:R:F138	R:R:V103	3.93	Yes	No	0	6	7
44	R:R:S373	R:R:V103	6.46	No	No	0	9	7
45	R:R:G104	R:R:M108	3.49	No	Yes	0	6	8
46	R:R:F106	R:R:L105	6.09	No	No	0	5	5
47	R:R:V107	R:R:W131	6.13	No	No	0	7	6
48	R:R:D135	R:R:V107	2.92	Yes	No	1	8	7
49	R:R:V107	R:R:Y370	3.79	No	Yes	1	7	8
50	R:R:M108	R:R:W367	3.49	Yes	Yes	1	8	7
51	R:R:M108	R:R:Y370	4.79	Yes	Yes	1	8	8
52	R:R:I110	R:R:W131	7.05	No	No	0	5	6
53	R:R:A111	R:R:W367	3.89	No	Yes	0	7	7
54	R:R:I115	R:R:W367	3.52	No	Yes	0	5	7
55	R:R:F117	R:R:M116	3.73	No	No	0	3	5
56	R:R:E118	R:R:M120	5.41	No	No	0	4	3
57	R:R:M120	R:R:N204	15.43	No	No	0	3	3
58	R:R:P122	R:R:W121	5.4	No	Yes	3	3	7
59	R:R:L123	R:R:W121	4.56	Yes	Yes	3	6	7
60	R:R:C128	R:R:W121	5.22	No	Yes	3	9	7
61	R:R:W121	R:R:W131	4.69	Yes	No	0	7	6
62	R:R:C207	R:R:W121	10.45	No	Yes	3	9	7
63	R:R:L123	R:R:P122	3.28	Yes	No	3	6	3
64	R:R:L123	R:R:P124	4.93	Yes	No	0	6	7
65	R:R:L127	R:R:P124	4.93	No	No	0	5	7
66	R:R:I205	R:R:L125	2.85	No	No	0	2	4
67	R:R:L127	R:R:V126	2.98	No	No	0	5	3
68	R:R:C128	R:R:P129	3.77	No	No	0	9	7
69	R:R:C128	R:R:C207	7.28	No	No	3	9	9
70	R:R:L132	R:R:V190	4.47	No	No	0	5	6
71	R:R:I195	R:R:L132	2.85	No	No	0	5	5
72	R:R:L132	R:R:L209	5.54	No	No	0	5	5
73	R:R:F133	R:R:P191	13	No	No	0	6	7
74	R:R:F138	R:R:L134	3.65	Yes	No	0	6	5
75	R:R:D135	R:R:S139	4.42	Yes	No	1	8	7
76	R:R:D135	R:R:Y370	10.34	Yes	Yes	1	8	8
77	L:L:?1	R:R:D135	18.04	Yes	Yes	1	0	8
78	R:R:A187	R:R:V136	3.39	No	No	0	8	7
79	L:L:?1	R:R:V136	15.14	Yes	No	0	0	7
80	R:R:F138	R:R:L137	3.65	Yes	No	0	6	6
81	R:R:L137	R:R:S183	3	No	No	0	6	8
82	R:R:I184	R:R:L137	2.85	No	No	0	4	6
83	L:L:?1	R:R:S139	5.87	Yes	No	1	0	7
84	R:R:S183	R:R:T140	6.4	No	No	0	8	7
85	R:R:I186	R:R:T140	3.04	No	No	0	6	7
86	R:R:A225	R:R:T140	3.36	No	No	0	7	7
87	R:R:A141	R:R:H145	2.93	No	Yes	2	8	8
88	R:R:A141	R:R:W180	3.89	No	Yes	2	8	9
89	R:R:A141	R:R:S183	3.42	No	No	0	8	8
90	R:R:I143	R:R:P229	3.39	No	No	0	8	9
91	R:R:F333	R:R:I143	3.77	No	No	0	9	8
92	R:R:I182	R:R:W144	10.57	No	No	0	5	6
93	R:R:P229	R:R:W144	8.11	No	No	0	9	6
94	R:R:H145	R:R:V179	5.54	Yes	No	0	8	7
95	R:R:H145	R:R:W180	4.23	Yes	Yes	2	8	9
96	R:R:L146	R:R:N376	4.12	No	No	0	9	9
97	R:R:L146	R:R:Y380	8.21	No	Yes	0	9	9
98	R:R:C147	R:R:I232	3.27	No	No	0	7	8
99	R:R:C147	R:R:M233	4.86	No	No	0	7	8
100	R:R:I149	R:R:R153	6.26	No	No	4	9	9
101	R:R:I149	R:R:Y380	3.63	No	Yes	4	9	9
102	R:R:S150	R:R:T236	4.8	No	No	0	9	6
103	R:R:D152	R:R:K175	12.44	No	No	0	9	6
104	R:R:L326	R:R:R153	4.86	No	No	0	8	9
105	R:R:R153	R:R:Y380	6.17	No	Yes	4	9	9
106	R:R:K158	R:R:Y154	7.17	No	No	0	7	8
107	R:R:T240	R:R:Y154	6.24	No	No	0	9	8
108	R:R:I157	R:R:L244	7.14	No	No	0	9	8
109	R:R:K159	R:R:Q162	6.78	No	No	0	6	5
110	R:R:I161	R:R:Q162	6.86	No	No	0	7	5
111	R:R:I161	R:R:Q165	4.12	No	No	0	7	5
112	R:R:Q162	R:R:Y166	3.38	No	No	0	5	5
113	R:R:I176	R:R:W180	3.52	No	Yes	2	7	9
114	R:R:I182	R:R:I186	2.94	No	No	0	5	6
115	R:R:I188	R:R:P189	5.08	No	No	0	4	8
116	R:R:P191	R:R:V190	3.53	No	No	0	7	6
117	R:R:F217	R:R:V190	3.93	No	No	0	7	6
118	R:R:K193	R:R:R213	3.71	No	Yes	0	4	3
119	R:R:E196	R:R:R213	11.63	No	Yes	0	5	3
120	R:R:P202	R:R:T197	8.74	No	No	0	3	4
121	R:R:D198	R:R:V199	5.84	No	No	0	4	3
122	R:R:N201	R:R:V199	2.96	Yes	No	0	2	3
123	R:R:D200	R:R:N201	10.77	No	Yes	0	4	2
124	R:R:N204	R:R:T206	4.39	No	No	0	3	4
125	R:R:F214	R:R:L209	12.18	No	No	0	5	5
126	R:R:R213	R:R:T210	3.88	Yes	No	0	3	5
127	R:R:K211	R:R:L347	4.23	Yes	No	0	5	4
128	R:R:F214	R:R:R213	4.28	No	Yes	0	5	3
129	R:R:F217	R:R:G221	3.01	No	No	0	7	6
130	L:L:?1	R:R:F217	2.86	Yes	No	0	0	7
131	R:R:M218	R:R:N344	7.01	No	No	0	6	6
132	R:R:M218	R:R:V348	3.04	No	No	0	6	5
133	R:R:F220	R:R:L219	8.53	No	No	0	4	5
134	R:R:F341	R:R:S222	3.96	Yes	No	0	7	7
135	R:R:I345	R:R:S222	3.1	No	No	0	6	7
136	R:R:F227	R:R:L223	3.65	No	No	0	6	4
137	R:R:F226	R:R:F227	9.65	Yes	No	0	8	6
138	R:R:F226	R:R:L230	3.65	Yes	No	0	8	6
139	R:R:F226	R:R:F333	3.22	Yes	No	0	8	9
140	R:R:F226	R:R:W337	3.01	Yes	No	1	8	8
141	R:R:C338	R:R:F226	4.19	No	Yes	0	6	8
142	R:R:F226	R:R:F341	18.22	Yes	Yes	1	8	7
143	R:R:P229	R:R:T228	5.25	No	No	0	9	5
144	R:R:L230	R:R:L334	4.15	No	No	0	6	5
145	R:R:I232	R:R:T236	3.04	No	No	0	8	6
146	R:R:F330	R:R:M233	3.73	No	No	0	8	8
147	R:R:F333	R:R:M233	8.71	No	No	0	9	8
148	R:R:L239	R:R:V235	2.98	No	No	0	6	4
149	R:R:F238	R:R:Y237	8.25	No	Yes	0	3	9
150	R:R:I241	R:R:Y237	12.09	No	Yes	0	5	9
151	R:R:G327	R:R:Y237	4.35	No	Yes	0	5	9
152	R:R:F330	R:R:Y237	5.16	No	Yes	0	8	9
153	R:R:I241	R:R:Q245	4.12	No	No	0	5	6
154	R:R:E319	R:R:L244	5.3	No	No	0	8	8
155	R:R:E319	R:R:K246	9.45	No	No	0	8	6
156	R:R:K247	R:R:S317	7.65	No	No	0	7	4
157	R:R:E319	R:R:K247	4.05	No	No	0	8	7
158	R:R:I316	R:R:Q320	4.12	No	No	0	4	6
159	R:R:I316	R:R:K324	5.82	No	No	0	4	7
160	R:R:Q320	R:R:S317	7.22	No	No	0	6	4
161	R:R:N318	R:R:R321	10.85	No	No	0	7	8
162	R:R:Q320	R:R:S323	2.89	No	No	0	6	7
163	R:R:F383	R:R:V325	15.73	No	No	0	7	8
164	R:R:V329	R:R:V379	3.21	No	No	0	8	8
165	R:R:V329	R:R:Y380	5.05	No	Yes	0	8	9
166	R:R:F331	R:R:L335	3.65	No	No	0	6	5
167	R:R:C338	R:R:L334	4.76	No	No	0	6	5
168	R:R:I368	R:R:M336	2.92	No	No	0	8	8
169	R:R:M336	R:R:S372	4.6	No	No	0	8	9
170	R:R:F341	R:R:W337	8.02	Yes	No	1	7	8
171	R:R:G369	R:R:W337	8.44	No	No	0	7	8
172	R:R:F365	R:R:P339	7.22	No	No	0	5	9
173	R:R:F340	R:R:F341	5.36	Yes	Yes	1	7	7
174	R:R:F340	R:R:L362	4.87	Yes	No	0	7	5
175	R:R:F340	R:R:V366	3.93	Yes	No	1	7	6
176	L:L:?1	R:R:F340	15.23	Yes	Yes	1	0	7
177	R:R:L362	R:R:T343	7.37	No	No	0	5	5
178	R:R:L349	R:R:V348	2.98	No	No	0	5	5
179	R:R:C350	R:R:S352	3.44	No	No	0	5	4
180	R:R:C350	R:R:C353	7.28	No	No	6	5	4
181	R:R:N354	R:R:T356	5.85	No	No	0	4	2
182	R:R:N354	R:R:T357	5.85	No	No	0	4	5
183	R:R:V366	R:R:Y370	6.31	No	Yes	1	6	8
184	L:L:?1	R:R:V366	4.66	Yes	No	1	0	6
185	R:R:W367	R:R:Y370	3.86	Yes	Yes	1	7	8
186	R:R:N376	R:R:S372	4.47	No	No	0	9	9
187	R:R:V375	R:R:V379	3.21	No	No	5	6	8
188	R:R:L378	R:R:P377	3.28	No	No	0	6	9
189	R:R:L382	R:R:T381	2.95	No	No	0	6	7
190	R:R:F387	R:R:T381	9.08	Yes	No	0	9	7
191	R:R:N384	R:R:T386	5.85	No	No	0	9	7
192	R:R:K385	R:R:R388	6.19	No	No	0	5	9
193	R:R:A78	R:R:F387	2.77	No	Yes	0	8	9
194	R:R:A78	R:R:F391	2.77	No	No	0	8	7
195	R:R:A148	R:R:F92	2.77	No	No	0	7	8
196	R:R:D351	R:R:K211	2.77	No	Yes	0	3	5
197	R:R:L219	R:R:L349	2.77	No	No	0	5	5
198	R:R:L347	R:R:L358	2.77	No	No	0	4	4
199	R:R:L378	R:R:L382	2.77	No	No	0	6	6
200	R:R:L93	R:R:N90	2.75	No	No	0	8	9
201	R:R:E82	R:R:I395	2.73	No	Yes	0	7	6
202	R:R:N201	R:R:N203	2.72	Yes	No	0	2	4
203	R:R:K211	R:R:Q355	2.71	Yes	No	0	5	3
204	R:R:E363	R:R:M360	2.71	No	No	0	5	2
205	R:R:E212	R:R:K211	2.7	No	Yes	0	5	5
206	R:R:F387	R:R:V79	2.62	Yes	No	0	9	8
207	R:R:A58	R:R:W56	2.59	No	No	0	6	4
208	R:R:A99	R:R:W180	2.59	No	Yes	0	8	9
209	R:R:F365	R:R:T343	2.59	No	No	0	5	5
210	R:R:F238	R:R:I234	2.51	No	No	0	3	5
211	R:R:I316	R:R:R321	2.51	No	No	0	4	8
212	R:R:T89	R:R:Y87	2.5	No	No	0	8	7
213	R:R:T114	R:R:W121	2.43	No	Yes	0	5	7
214	R:R:L382	R:R:R388	2.43	No	No	0	6	9
215	R:R:Q86	R:R:Y91	2.25	No	No	0	8	5
216	L:L:?1	R:R:N344	2.15	Yes	No	0	0	6
217	R:R:F173	R:R:R169	2.14	No	Yes	0	4	4
218	R:R:G70	R:R:G71	2.11	No	No	0	4	8
219	R:R:G70	R:R:T73	1.82	No	No	0	4	4
220	R:R:A156	R:R:A163	1.79	No	No	0	8	8
221	R:R:G185	R:R:I184	1.76	No	No	0	5	4
222	R:R:C147	R:R:V151	1.71	No	No	0	7	6
223	R:R:A97	R:R:V75	1.7	No	No	0	9	9
224	R:R:I205	R:R:P202	1.69	No	No	0	2	3
225	R:R:C350	R:R:T346	1.69	No	No	6	5	5
226	R:R:C353	R:R:T346	1.69	No	No	6	4	5
227	R:R:K159	R:R:P160	1.67	No	No	0	6	8
228	R:R:C338	R:R:I342	1.64	No	No	0	6	6
229	R:R:N201	R:R:P202	1.63	Yes	No	0	2	3
230	R:R:A163	R:R:I155	1.62	No	No	0	8	5
231	R:R:A243	R:R:I157	1.62	No	No	0	6	9
232	R:R:A224	R:R:I186	1.62	No	No	0	4	6
233	R:R:A58	R:R:M116	1.61	No	No	0	6	5
234	R:R:A119	R:R:M120	1.61	No	No	0	3	3
235	R:R:A243	R:R:K158	1.61	No	No	0	6	7
236	R:R:T210	R:R:V208	1.59	No	No	0	5	3
237	R:R:C353	R:R:L358	1.59	No	No	0	4	4
238	R:R:A322	R:R:L244	1.58	No	No	0	8	8
239	R:R:I76	R:R:S80	1.55	No	No	0	7	4
240	R:R:I182	R:R:V178	1.54	No	No	0	5	3
241	R:R:I174	R:R:T177	1.52	No	No	0	4	3
242	R:R:I342	R:R:T346	1.52	No	No	0	6	5
243	R:R:K84	R:R:T386	1.5	No	No	0	6	7
244	R:R:L332	R:R:V375	1.49	No	No	5	5	6
245	R:R:L332	R:R:V379	1.49	No	No	5	5	8
246	R:R:I184	R:R:I188	1.47	No	No	0	4	4
247	R:R:I195	R:R:I205	1.47	No	No	0	5	2
248	R:R:L326	R:R:T240	1.47	No	No	0	8	9
249	R:R:N167	R:R:T89	1.46	No	No	0	7	8
250	R:R:N167	R:R:T171	1.46	No	No	0	7	7
251	R:R:K158	R:R:K159	1.44	No	No	0	7	6
252	R:R:I61	R:R:L62	1.43	No	No	0	7	3
253	R:R:A130	R:R:F133	1.39	No	No	0	4	6
254	R:R:A88	R:R:R169	1.38	No	Yes	0	6	4
255	R:R:L113	R:R:L123	1.38	No	Yes	0	5	6
256	R:R:L358	R:R:L361	1.38	No	No	0	4	5
257	R:R:N203	R:R:N204	1.36	No	No	0	4	3
258	R:R:A172	R:R:Y91	1.33	No	No	0	7	5
259	R:R:L347	R:R:Q359	1.33	No	No	0	4	2
260	R:R:R169	R:R:S168	1.32	Yes	No	0	4	8
261	R:R:F117	R:R:L113	1.22	No	No	0	3	5
262	R:R:L239	R:R:Y154	1.17	No	No	0	6	8
263	R:R:R393	R:R:Y394	1.03	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N72	5.9	4	0	9
2	R:R:D100	6.182	5	0	9
3	R:R:M108	4.128	5	1	8
4	R:R:W121	5.45833	6	3	7
5	R:R:L123	3.5375	4	3	6
6	R:R:D135	8.93	4	1	8
7	R:R:F138	5.2425	4	0	6
8	R:R:H145	5.955	6	2	8
9	R:R:R169	4.555	4	0	4
10	R:R:W180	4.082	5	2	9
11	R:R:N201	4.52	4	0	2
12	R:R:K211	3.1025	4	0	5
13	R:R:R213	5.875	4	0	3
14	R:R:F226	6.99	6	1	8
15	R:R:Y237	7.4625	4	0	9
16	R:R:F340	7.3475	4	1	7
17	R:R:F341	8.89	4	1	7
18	R:R:W367	4.596	5	1	7
19	R:R:Y370	5.818	5	1	8
20	R:R:Y380	5.765	4	4	9
21	R:R:F387	7.024	5	0	9
22	R:R:I395	4.25	4	0	6
23	L:L:?1	9.13571	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V366	R:R:Y370	34.2485	6.31	No	Yes	1	6	8
2	R:R:F340	R:R:V366	32.2001	3.93	Yes	No	1	7	6
3	R:R:F340	R:R:F341	93.1454	5.36	Yes	Yes	1	7	7
4	R:R:F226	R:R:F341	93.1209	18.22	Yes	Yes	1	8	7
5	R:R:F226	R:R:F333	99.5903	3.22	Yes	No	0	8	9
6	R:R:F333	R:R:I143	100	3.77	No	No	0	9	8
7	R:R:I143	R:R:P229	99.9266	3.39	No	No	0	8	9
8	R:R:P229	R:R:W144	99.7432	8.11	No	No	0	9	6
9	R:R:I182	R:R:W144	99.6331	10.57	No	No	0	5	6
10	R:R:I182	R:R:I186	99.3763	2.94	No	No	0	5	6
11	R:R:I186	R:R:T140	99.0706	3.04	No	No	0	6	7
12	R:R:S183	R:R:T140	98.7159	6.4	No	No	0	8	7
13	R:R:A141	R:R:S183	87.7339	3.42	No	No	0	8	8
14	R:R:A141	R:R:H145	83.5637	2.93	No	Yes	2	8	8
15	R:R:H145	R:R:L96	83.2273	9	Yes	No	0	8	9
16	R:R:D100	R:R:L96	82.8177	4.07	Yes	No	0	9	9
17	R:R:D100	R:R:N72	59.0253	4.04	Yes	Yes	0	9	9
18	R:R:L137	R:R:S183	12.26	3	No	No	0	6	8
19	R:R:F138	R:R:L137	10.4256	3.65	Yes	No	0	6	6
20	R:R:N72	R:R:P377	51.8589	9.77	Yes	No	0	9	9
21	R:R:A78	R:R:F391	10.7374	2.77	No	No	0	8	7
22	R:R:A78	R:R:F387	12.2233	2.77	No	Yes	0	8	9
23	R:R:F387	R:R:T381	42.644	9.08	Yes	No	0	9	7
24	R:R:L382	R:R:T381	46.2028	2.95	No	No	0	6	7
25	R:R:L378	R:R:L382	49.6331	2.77	No	No	0	6	6
26	R:R:L378	R:R:P377	50.7521	3.28	No	No	0	6	9
27	R:R:F387	R:R:N90	20.6188	6.04	Yes	No	0	9	9
28	R:R:N90	R:R:Y87	17.91	15.12	No	No	0	9	7
29	R:R:T89	R:R:Y87	16.473	2.5	No	No	0	8	7
30	R:R:N167	R:R:T89	15.0177	1.46	No	No	0	7	8
31	R:R:A88	R:R:N167	12.2172	4.69	No	No	0	6	7
32	R:R:A88	R:R:R169	10.7374	1.38	No	Yes	0	6	4
33	R:R:D100	R:R:N376	50.7643	8.08	Yes	No	0	9	9
34	R:R:V107	R:R:Y370	19.671	3.79	No	Yes	1	7	8
35	R:R:V107	R:R:W131	39.8924	6.13	No	No	0	7	6
36	R:R:L113	R:R:L123	12.0704	1.38	No	Yes	0	5	6
37	R:R:L123	R:R:W121	21.6033	4.56	Yes	Yes	3	6	7
38	R:R:W121	R:R:W131	35.4837	4.69	Yes	No	0	7	6
39	R:R:N201	R:R:P202	14.7915	1.63	Yes	No	0	2	3
40	R:R:I205	R:R:P202	17.6043	1.69	No	No	0	2	3
41	R:R:I195	R:R:I205	20.3375	1.47	No	No	0	5	2
42	R:R:I195	R:R:L132	21.536	2.85	No	No	0	5	5
43	R:R:L132	R:R:V190	31.7537	4.47	No	No	0	5	6
44	R:R:F217	R:R:V190	36.6271	3.93	No	No	0	7	6
45	L:L:?1	R:R:F217	38.9079	2.86	Yes	No	0	0	7
46	L:L:?1	R:R:D135	26.4339	18.04	Yes	Yes	1	0	8
47	R:R:L146	R:R:N376	46.215	4.12	No	No	0	9	9
48	R:R:L146	R:R:Y380	45.0165	8.21	No	Yes	0	9	9
49	R:R:F333	R:R:M233	19.1452	8.71	No	No	0	9	8
50	R:R:R153	R:R:Y380	37.5749	6.17	No	Yes	4	9	9
51	R:R:L326	R:R:R153	36.6027	4.86	No	No	0	8	9
52	R:R:L326	R:R:T240	35.4714	1.47	No	No	0	8	9
53	R:R:T240	R:R:Y154	34.1996	6.24	No	No	0	9	8
54	R:R:K158	R:R:Y154	30.2923	7.17	No	No	0	7	8
55	R:R:A243	R:R:I157	19.3347	1.62	No	No	0	6	9
56	R:R:A243	R:R:K158	20.7472	1.61	No	No	0	6	7
57	R:R:I157	R:R:L244	17.91	7.14	No	No	0	9	8
58	R:R:L132	R:R:L209	10.2727	5.54	No	No	0	5	5
59	R:R:C338	R:R:F226	21.9457	4.19	No	Yes	0	6	8
60	R:R:C338	R:R:I342	19.243	1.64	No	No	0	6	6
61	R:R:I342	R:R:T346	17.8244	1.52	No	No	0	6	5
62	R:R:C353	R:R:T346	13.3851	1.69	No	No	6	4	5
63	R:R:C353	R:R:L358	12.0276	1.59	No	No	0	4	4
64	R:R:F330	R:R:M233	10.6824	3.73	No	No	0	8	8
65	R:R:E319	R:R:L244	15.1584	5.3	No	No	0	8	8
66	R:R:E319	R:R:K247	12.2111	4.05	No	No	0	8	7
67	R:R:K247	R:R:S317	10.7313	7.65	No	No	0	7	4
68	L:L:?1	R:R:F340	58.7379	15.23	Yes	Yes	1	0	7
69	R:R:D135	R:R:V107	22.496	2.92	Yes	No	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D135	R:R:V107	2.92	1	Yes	No	8	7	1	2
R:R:V107	R:R:Y370	3.79	1	No	Yes	7	8	2	2
R:R:D135	R:R:S139	4.42	1	Yes	No	8	7	1	1
R:R:D135	R:R:Y370	10.34	1	Yes	Yes	8	8	1	2
L:L:?1	R:R:D135	18.04	1	Yes	Yes	0	8	0	1
R:R:A187	R:R:V136	3.39	0	No	No	8	7	2	1
L:L:?1	R:R:V136	15.14	1	Yes	No	0	7	0	1
L:L:?1	R:R:S139	5.87	1	Yes	No	0	7	0	1
R:R:F217	R:R:V190	3.93	0	No	No	7	6	1	2
R:R:F217	R:R:G221	3.01	0	No	No	7	6	1	2
L:L:?1	R:R:F217	2.86	1	Yes	No	0	7	0	1
R:R:M218	R:R:N344	7.01	0	No	No	6	6	2	1
R:R:F340	R:R:F341	5.36	1	Yes	Yes	7	7	1	2
R:R:F340	R:R:L362	4.87	1	Yes	No	7	5	1	2
R:R:F340	R:R:V366	3.93	1	Yes	No	7	6	1	1
L:L:?1	R:R:F340	15.23	1	Yes	Yes	0	7	0	1
R:R:V366	R:R:Y370	6.31	1	No	Yes	6	8	1	2
L:L:?1	R:R:V366	4.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:N344	2.15	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7SRR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	255
Number of Links	263
Number of Hubs	23
Number of Links mediated by Hubs	96
Number of Communities	6
Number of Nodes involved in Communities	31
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	31485
Length Of Smallest Path	3
Average Path Length	18.4435
Length of Longest Path	45
Minimum Path Strength	1.3
Average Path Strength	5.54714
Maximum Path Strength	16.635
Minimum Path Correlation	0.7
Average Path Correlation	0.930535
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	51.9415
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	27.1343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • Gq/11-coupled serotonin receptor activity • protein binding • G-protein alpha-subunit binding • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • cellular process • positive regulation of signaling • intestine smooth muscle contraction • multicellular organismal process • gastro-intestinal system smooth muscle contraction • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • developmental process • neural crest cell differentiation • cellular developmental process • animal organ development • mesenchyme development • tissue development • stem cell differentiation • cell differentiation • anatomical structure development • mesenchymal cell differentiation • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of lipid metabolic process • glycerophospholipid metabolic process • lipid biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • phospholipid metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • positive regulation of lipid metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • regulation of phosphatidylinositol biosynthetic process • regulation of biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • primary metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • biosynthetic process • positive regulation of lipid biosynthetic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • metabolic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • calcium-mediated signaling • stem cell development • neural crest cell development • cell development • mesenchymal cell migration • ameboidal-type cell migration • cell migration • cell motility • neural crest cell migration • positive regulation of cell division • cell division • regulation of cell division • regulation of behavior • behavior • regulation of multicellular organismal process • multicellular organism development • anatomical structure morphogenesis • embryonic morphogenesis • embryo development • heart development • heart morphogenesis • circulatory system development • animal organ morphogenesis • system development • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • regulation of localization • cellular localization • transport • monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • calcium ion transport • metal ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • localization • monoatomic ion transport • monoatomic cation transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • muscle hypertrophy • cardiac muscle hypertrophy • striated muscle hypertrophy • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of endothelial cell proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure
Gene Ontology	Cellular Component	• protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyl-(+)-lysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41595
Sequence	>7SRR_nogp_Chain_R W A A L L I L M V I I P T I G G N T L V I L A V S L E K K L Q Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F E A M W P L P L V L C P A W L F L D V L F S T A S I W H L C A I S V D R Y I A I K K P I Q A N Q Y N S R A T A F I K I T V V W L I S I G I A I P V P I K G I E T D V D N P N N I T C V L T K E R F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C D S C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F R D A F G R Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5TVN	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	-	2.9	2017-02-01	doi.org/10.1016/j.cell.2016.12.033
	7SRQ	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	-	2.7	2022-09-21	doi.org/10.1016/j.neuron.2022.08.006
	7SRR	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2022-09-21	doi.org/10.1016/j.neuron.2022.08.006
	7SRR (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-		2.9	2022-09-21	doi.org/10.1016/j.neuron.2022.08.006
	7SRS	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	Arrestin2	3.3	2022-09-21	doi.org/10.1016/j.neuron.2022.08.006
	6DRX	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Lisuride	-	-	3.1	2018-08-29	doi.org/10.1038/s41594-018-0116-7
	6DRY	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Methylergonovine	-	-	2.92	2018-08-29	doi.org/10.1038/s41594-018-0116-7
	6DRZ	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Methysergide	-	-	3.1	2018-08-29	doi.org/10.1038/s41594-018-0116-7
	6DS0	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ly266097	-	-	3.19	2018-08-29	doi.org/10.1038/s41594-018-0116-7
	5TUD	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	3	2017-07-26	doi.org/10.1073/pnas.1700891114
	4IB4	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	2.7	2013-03-13	doi.org/10.1126/science.1232808
	4NC3	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	2.8	2013-12-18	doi.org/10.1126/science.1244142
	9JGK	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Balovaptan	-	-	3.6	2025-07-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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