psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I61	R:R:L112	5.71	No	No	0	7	6
2	R:R:I61	R:R:W367	8.22	No	Yes	0	7	7
3	R:R:M108	R:R:V64	3.04	Yes	No	0	8	7
4	R:R:V371	R:R:V64	3.21	No	No	0	5	7
5	R:R:I65	R:R:M108	5.83	No	Yes	0	6	8
6	R:R:I65	R:R:P109	3.39	No	No	0	6	9
7	R:R:I66	R:R:P67	3.39	No	No	0	4	4
8	R:R:N72	R:R:T68	2.92	Yes	No	0	9	8
9	R:R:G374	R:R:T68	3.64	No	No	0	7	8
10	R:R:I69	R:R:L101	2.85	No	No	0	7	7
11	R:R:I69	R:R:L105	2.85	No	No	0	7	5
12	R:R:D100	R:R:N72	4.04	Yes	Yes	0	9	9
13	R:R:L101	R:R:N72	6.87	No	Yes	0	7	9
14	R:R:N72	R:R:P377	9.77	Yes	No	0	9	9
15	R:R:L101	R:R:T73	2.95	No	No	0	7	4
16	R:R:F391	R:R:L74	6.09	No	No	0	7	7
17	R:R:I395	R:R:L74	4.28	Yes	No	0	6	7
18	R:R:T381	R:R:V75	4.76	No	No	0	7	9
19	R:R:I76	R:R:M94	2.92	No	No	0	7	7
20	R:R:I395	R:R:L77	4.28	Yes	No	0	6	4
21	R:R:M94	R:R:V79	6.09	No	No	0	7	8
22	R:R:I395	R:R:L81	5.71	Yes	No	0	6	4
23	R:R:A390	R:R:E82	6.03	No	No	0	7	7
24	R:R:K83	R:R:Q86	4.07	No	No	0	7	8
25	R:R:L85	R:R:T386	5.9	No	No	0	8	7
26	R:R:F387	R:R:L85	14.61	Yes	No	0	9	8
27	R:R:N90	R:R:Y87	15.12	No	No	0	9	7
28	R:R:A88	R:R:N167	4.69	No	No	0	6	7
29	R:R:F387	R:R:N90	6.04	Yes	No	0	9	9
30	R:R:R169	R:R:Y91	13.38	Yes	No	0	4	5
31	R:R:F92	R:R:H145	5.66	No	Yes	0	8	8
32	R:R:F92	R:R:K175	3.72	No	No	0	8	6
33	R:R:H145	R:R:S95	8.37	Yes	No	2	8	9
34	R:R:I176	R:R:S95	9.29	No	No	2	7	9
35	R:R:S95	R:R:W180	6.18	No	Yes	2	9	9
36	R:R:D100	R:R:L96	4.07	Yes	No	0	9	9
37	R:R:H145	R:R:L96	9	Yes	No	0	8	9
38	R:R:D100	R:R:S142	5.89	Yes	No	0	9	9
39	R:R:D100	R:R:S373	8.83	Yes	No	0	9	9
40	R:R:D100	R:R:N376	8.08	Yes	No	0	9	9
41	R:R:F106	R:R:L102	3.65	No	No	0	5	7
42	R:R:F138	R:R:L102	9.74	Yes	No	0	6	7
43	R:R:F138	R:R:V103	3.93	Yes	No	0	6	7
44	R:R:S373	R:R:V103	6.46	No	No	0	9	7
45	R:R:G104	R:R:M108	3.49	No	Yes	0	6	8
46	R:R:F106	R:R:L105	6.09	No	No	0	5	5
47	R:R:V107	R:R:W131	6.13	No	No	0	7	6
48	R:R:D135	R:R:V107	2.92	Yes	No	1	8	7
49	R:R:V107	R:R:Y370	3.79	No	Yes	1	7	8
50	R:R:M108	R:R:W367	3.49	Yes	Yes	1	8	7
51	R:R:M108	R:R:Y370	4.79	Yes	Yes	1	8	8
52	R:R:I110	R:R:W131	7.05	No	No	0	5	6
53	R:R:A111	R:R:W367	3.89	No	Yes	0	7	7
54	R:R:I115	R:R:W367	3.52	No	Yes	0	5	7
55	R:R:F117	R:R:M116	3.73	No	No	0	3	5
56	R:R:E118	R:R:M120	5.41	No	No	0	4	3
57	R:R:M120	R:R:N204	15.43	No	No	0	3	3
58	R:R:P122	R:R:W121	5.4	No	Yes	3	3	7
59	R:R:L123	R:R:W121	4.56	Yes	Yes	3	6	7
60	R:R:C128	R:R:W121	5.22	No	Yes	3	9	7
61	R:R:W121	R:R:W131	4.69	Yes	No	0	7	6
62	R:R:C207	R:R:W121	10.45	No	Yes	3	9	7
63	R:R:L123	R:R:P122	3.28	Yes	No	3	6	3
64	R:R:L123	R:R:P124	4.93	Yes	No	0	6	7
65	R:R:L127	R:R:P124	4.93	No	No	0	5	7
66	R:R:I205	R:R:L125	2.85	No	No	0	2	4
67	R:R:L127	R:R:V126	2.98	No	No	0	5	3
68	R:R:C128	R:R:P129	3.77	No	No	0	9	7
69	R:R:C128	R:R:C207	7.28	No	No	3	9	9
70	R:R:L132	R:R:V190	4.47	No	No	0	5	6
71	R:R:I195	R:R:L132	2.85	No	No	0	5	5
72	R:R:L132	R:R:L209	5.54	No	No	0	5	5
73	R:R:F133	R:R:P191	13	No	No	0	6	7
74	R:R:F138	R:R:L134	3.65	Yes	No	0	6	5
75	R:R:D135	R:R:S139	4.42	Yes	No	1	8	7
76	R:R:D135	R:R:Y370	10.34	Yes	Yes	1	8	8
77	L:L:?1	R:R:D135	18.04	Yes	Yes	1	0	8
78	R:R:A187	R:R:V136	3.39	No	No	0	8	7
79	L:L:?1	R:R:V136	15.14	Yes	No	0	0	7
80	R:R:F138	R:R:L137	3.65	Yes	No	0	6	6
81	R:R:L137	R:R:S183	3	No	No	0	6	8
82	R:R:I184	R:R:L137	2.85	No	No	0	4	6
83	L:L:?1	R:R:S139	5.87	Yes	No	1	0	7
84	R:R:S183	R:R:T140	6.4	No	No	0	8	7
85	R:R:I186	R:R:T140	3.04	No	No	0	6	7
86	R:R:A225	R:R:T140	3.36	No	No	0	7	7
87	R:R:A141	R:R:H145	2.93	No	Yes	2	8	8
88	R:R:A141	R:R:W180	3.89	No	Yes	2	8	9
89	R:R:A141	R:R:S183	3.42	No	No	0	8	8
90	R:R:I143	R:R:P229	3.39	No	No	0	8	9
91	R:R:F333	R:R:I143	3.77	No	No	0	9	8
92	R:R:I182	R:R:W144	10.57	No	No	0	5	6
93	R:R:P229	R:R:W144	8.11	No	No	0	9	6
94	R:R:H145	R:R:V179	5.54	Yes	No	0	8	7
95	R:R:H145	R:R:W180	4.23	Yes	Yes	2	8	9
96	R:R:L146	R:R:N376	4.12	No	No	0	9	9
97	R:R:L146	R:R:Y380	8.21	No	Yes	0	9	9
98	R:R:C147	R:R:I232	3.27	No	No	0	7	8
99	R:R:C147	R:R:M233	4.86	No	No	0	7	8
100	R:R:I149	R:R:R153	6.26	No	No	4	9	9
101	R:R:I149	R:R:Y380	3.63	No	Yes	4	9	9
102	R:R:S150	R:R:T236	4.8	No	No	0	9	6
103	R:R:D152	R:R:K175	12.44	No	No	0	9	6
104	R:R:L326	R:R:R153	4.86	No	No	0	8	9
105	R:R:R153	R:R:Y380	6.17	No	Yes	4	9	9
106	R:R:K158	R:R:Y154	7.17	No	No	0	7	8
107	R:R:T240	R:R:Y154	6.24	No	No	0	9	8
108	R:R:I157	R:R:L244	7.14	No	No	0	9	8
109	R:R:K159	R:R:Q162	6.78	No	No	0	6	5
110	R:R:I161	R:R:Q162	6.86	No	No	0	7	5
111	R:R:I161	R:R:Q165	4.12	No	No	0	7	5
112	R:R:Q162	R:R:Y166	3.38	No	No	0	5	5
113	R:R:I176	R:R:W180	3.52	No	Yes	2	7	9
114	R:R:I182	R:R:I186	2.94	No	No	0	5	6
115	R:R:I188	R:R:P189	5.08	No	No	0	4	8
116	R:R:P191	R:R:V190	3.53	No	No	0	7	6
117	R:R:F217	R:R:V190	3.93	No	No	0	7	6
118	R:R:K193	R:R:R213	3.71	No	Yes	0	4	3
119	R:R:E196	R:R:R213	11.63	No	Yes	0	5	3
120	R:R:P202	R:R:T197	8.74	No	No	0	3	4
121	R:R:D198	R:R:V199	5.84	No	No	0	4	3
122	R:R:N201	R:R:V199	2.96	Yes	No	0	2	3
123	R:R:D200	R:R:N201	10.77	No	Yes	0	4	2
124	R:R:N204	R:R:T206	4.39	No	No	0	3	4
125	R:R:F214	R:R:L209	12.18	No	No	0	5	5
126	R:R:R213	R:R:T210	3.88	Yes	No	0	3	5
127	R:R:K211	R:R:L347	4.23	Yes	No	0	5	4
128	R:R:F214	R:R:R213	4.28	No	Yes	0	5	3
129	R:R:F217	R:R:G221	3.01	No	No	0	7	6
130	L:L:?1	R:R:F217	2.86	Yes	No	0	0	7
131	R:R:M218	R:R:N344	7.01	No	No	0	6	6
132	R:R:M218	R:R:V348	3.04	No	No	0	6	5
133	R:R:F220	R:R:L219	8.53	No	No	0	4	5
134	R:R:F341	R:R:S222	3.96	Yes	No	0	7	7
135	R:R:I345	R:R:S222	3.1	No	No	0	6	7
136	R:R:F227	R:R:L223	3.65	No	No	0	6	4
137	R:R:F226	R:R:F227	9.65	Yes	No	0	8	6
138	R:R:F226	R:R:L230	3.65	Yes	No	0	8	6
139	R:R:F226	R:R:F333	3.22	Yes	No	0	8	9
140	R:R:F226	R:R:W337	3.01	Yes	No	1	8	8
141	R:R:C338	R:R:F226	4.19	No	Yes	0	6	8
142	R:R:F226	R:R:F341	18.22	Yes	Yes	1	8	7
143	R:R:P229	R:R:T228	5.25	No	No	0	9	5
144	R:R:L230	R:R:L334	4.15	No	No	0	6	5
145	R:R:I232	R:R:T236	3.04	No	No	0	8	6
146	R:R:F330	R:R:M233	3.73	No	No	0	8	8
147	R:R:F333	R:R:M233	8.71	No	No	0	9	8
148	R:R:L239	R:R:V235	2.98	No	No	0	6	4
149	R:R:F238	R:R:Y237	8.25	No	Yes	0	3	9
150	R:R:I241	R:R:Y237	12.09	No	Yes	0	5	9
151	R:R:G327	R:R:Y237	4.35	No	Yes	0	5	9
152	R:R:F330	R:R:Y237	5.16	No	Yes	0	8	9
153	R:R:I241	R:R:Q245	4.12	No	No	0	5	6
154	R:R:E319	R:R:L244	5.3	No	No	0	8	8
155	R:R:E319	R:R:K246	9.45	No	No	0	8	6
156	R:R:K247	R:R:S317	7.65	No	No	0	7	4
157	R:R:E319	R:R:K247	4.05	No	No	0	8	7
158	R:R:I316	R:R:Q320	4.12	No	No	0	4	6
159	R:R:I316	R:R:K324	5.82	No	No	0	4	7
160	R:R:Q320	R:R:S317	7.22	No	No	0	6	4
161	R:R:N318	R:R:R321	10.85	No	No	0	7	8
162	R:R:Q320	R:R:S323	2.89	No	No	0	6	7
163	R:R:F383	R:R:V325	15.73	No	No	0	7	8
164	R:R:V329	R:R:V379	3.21	No	No	0	8	8
165	R:R:V329	R:R:Y380	5.05	No	Yes	0	8	9
166	R:R:F331	R:R:L335	3.65	No	No	0	6	5
167	R:R:C338	R:R:L334	4.76	No	No	0	6	5
168	R:R:I368	R:R:M336	2.92	No	No	0	8	8
169	R:R:M336	R:R:S372	4.6	No	No	0	8	9
170	R:R:F341	R:R:W337	8.02	Yes	No	1	7	8
171	R:R:G369	R:R:W337	8.44	No	No	0	7	8
172	R:R:F365	R:R:P339	7.22	No	No	0	5	9
173	R:R:F340	R:R:F341	5.36	Yes	Yes	1	7	7
174	R:R:F340	R:R:L362	4.87	Yes	No	0	7	5
175	R:R:F340	R:R:V366	3.93	Yes	No	1	7	6
176	L:L:?1	R:R:F340	15.23	Yes	Yes	1	0	7
177	R:R:L362	R:R:T343	7.37	No	No	0	5	5
178	R:R:L349	R:R:V348	2.98	No	No	0	5	5
179	R:R:C350	R:R:S352	3.44	No	No	0	5	4
180	R:R:C350	R:R:C353	7.28	No	No	6	5	4
181	R:R:N354	R:R:T356	5.85	No	No	0	4	2
182	R:R:N354	R:R:T357	5.85	No	No	0	4	5
183	R:R:V366	R:R:Y370	6.31	No	Yes	1	6	8
184	L:L:?1	R:R:V366	4.66	Yes	No	1	0	6
185	R:R:W367	R:R:Y370	3.86	Yes	Yes	1	7	8
186	R:R:N376	R:R:S372	4.47	No	No	0	9	9
187	R:R:V375	R:R:V379	3.21	No	No	5	6	8
188	R:R:L378	R:R:P377	3.28	No	No	0	6	9
189	R:R:L382	R:R:T381	2.95	No	No	0	6	7
190	R:R:F387	R:R:T381	9.08	Yes	No	0	9	7
191	R:R:N384	R:R:T386	5.85	No	No	0	9	7
192	R:R:K385	R:R:R388	6.19	No	No	0	5	9
193	R:R:A78	R:R:F387	2.77	No	Yes	0	8	9
194	R:R:A78	R:R:F391	2.77	No	No	0	8	7
195	R:R:A148	R:R:F92	2.77	No	No	0	7	8
196	R:R:D351	R:R:K211	2.77	No	Yes	0	3	5
197	R:R:L219	R:R:L349	2.77	No	No	0	5	5
198	R:R:L347	R:R:L358	2.77	No	No	0	4	4
199	R:R:L378	R:R:L382	2.77	No	No	0	6	6
200	R:R:L93	R:R:N90	2.75	No	No	0	8	9
201	R:R:E82	R:R:I395	2.73	No	Yes	0	7	6
202	R:R:N201	R:R:N203	2.72	Yes	No	0	2	4
203	R:R:K211	R:R:Q355	2.71	Yes	No	0	5	3
204	R:R:E363	R:R:M360	2.71	No	No	0	5	2
205	R:R:E212	R:R:K211	2.7	No	Yes	0	5	5
206	R:R:F387	R:R:V79	2.62	Yes	No	0	9	8
207	R:R:A58	R:R:W56	2.59	No	No	0	6	4
208	R:R:A99	R:R:W180	2.59	No	Yes	0	8	9
209	R:R:F365	R:R:T343	2.59	No	No	0	5	5
210	R:R:F238	R:R:I234	2.51	No	No	0	3	5
211	R:R:I316	R:R:R321	2.51	No	No	0	4	8
212	R:R:T89	R:R:Y87	2.5	No	No	0	8	7
213	R:R:T114	R:R:W121	2.43	No	Yes	0	5	7
214	R:R:L382	R:R:R388	2.43	No	No	0	6	9
215	R:R:Q86	R:R:Y91	2.25	No	No	0	8	5
216	L:L:?1	R:R:N344	2.15	Yes	No	0	0	6
217	R:R:F173	R:R:R169	2.14	No	Yes	0	4	4
218	R:R:G70	R:R:G71	2.11	No	No	0	4	8
219	R:R:G70	R:R:T73	1.82	No	No	0	4	4
220	R:R:A156	R:R:A163	1.79	No	No	0	8	8
221	R:R:G185	R:R:I184	1.76	No	No	0	5	4
222	R:R:C147	R:R:V151	1.71	No	No	0	7	6
223	R:R:A97	R:R:V75	1.7	No	No	0	9	9
224	R:R:I205	R:R:P202	1.69	No	No	0	2	3
225	R:R:C350	R:R:T346	1.69	No	No	6	5	5
226	R:R:C353	R:R:T346	1.69	No	No	6	4	5
227	R:R:K159	R:R:P160	1.67	No	No	0	6	8
228	R:R:C338	R:R:I342	1.64	No	No	0	6	6
229	R:R:N201	R:R:P202	1.63	Yes	No	0	2	3
230	R:R:A163	R:R:I155	1.62	No	No	0	8	5
231	R:R:A243	R:R:I157	1.62	No	No	0	6	9
232	R:R:A224	R:R:I186	1.62	No	No	0	4	6
233	R:R:A58	R:R:M116	1.61	No	No	0	6	5
234	R:R:A119	R:R:M120	1.61	No	No	0	3	3
235	R:R:A243	R:R:K158	1.61	No	No	0	6	7
236	R:R:T210	R:R:V208	1.59	No	No	0	5	3
237	R:R:C353	R:R:L358	1.59	No	No	0	4	4
238	R:R:A322	R:R:L244	1.58	No	No	0	8	8
239	R:R:I76	R:R:S80	1.55	No	No	0	7	4
240	R:R:I182	R:R:V178	1.54	No	No	0	5	3
241	R:R:I174	R:R:T177	1.52	No	No	0	4	3
242	R:R:I342	R:R:T346	1.52	No	No	0	6	5
243	R:R:K84	R:R:T386	1.5	No	No	0	6	7
244	R:R:L332	R:R:V375	1.49	No	No	5	5	6
245	R:R:L332	R:R:V379	1.49	No	No	5	5	8
246	R:R:I184	R:R:I188	1.47	No	No	0	4	4
247	R:R:I195	R:R:I205	1.47	No	No	0	5	2
248	R:R:L326	R:R:T240	1.47	No	No	0	8	9
249	R:R:N167	R:R:T89	1.46	No	No	0	7	8
250	R:R:N167	R:R:T171	1.46	No	No	0	7	7
251	R:R:K158	R:R:K159	1.44	No	No	0	7	6
252	R:R:I61	R:R:L62	1.43	No	No	0	7	3
253	R:R:A130	R:R:F133	1.39	No	No	0	4	6
254	R:R:A88	R:R:R169	1.38	No	Yes	0	6	4
255	R:R:L113	R:R:L123	1.38	No	Yes	0	5	6
256	R:R:L358	R:R:L361	1.38	No	No	0	4	5
257	R:R:N203	R:R:N204	1.36	No	No	0	4	3
258	R:R:A172	R:R:Y91	1.33	No	No	0	7	5
259	R:R:L347	R:R:Q359	1.33	No	No	0	4	2
260	R:R:R169	R:R:S168	1.32	Yes	No	0	4	8
261	R:R:F117	R:R:L113	1.22	No	No	0	3	5
262	R:R:L239	R:R:Y154	1.17	No	No	0	6	8
263	R:R:R393	R:R:Y394	1.03	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N72	5.9	4	0	9
2	R:R:D100	6.182	5	0	9
3	R:R:M108	4.128	5	1	8
4	R:R:W121	5.45833	6	3	7
5	R:R:L123	3.5375	4	3	6
6	R:R:D135	8.93	4	1	8
7	R:R:F138	5.2425	4	0	6
8	R:R:H145	5.955	6	2	8
9	R:R:R169	4.555	4	0	4
10	R:R:W180	4.082	5	2	9
11	R:R:N201	4.52	4	0	2
12	R:R:K211	3.1025	4	0	5
13	R:R:R213	5.875	4	0	3
14	R:R:F226	6.99	6	1	8
15	R:R:Y237	7.4625	4	0	9
16	R:R:F340	7.3475	4	1	7
17	R:R:F341	8.89	4	1	7
18	R:R:W367	4.596	5	1	7
19	R:R:Y370	5.818	5	1	8
20	R:R:Y380	5.765	4	4	9
21	R:R:F387	7.024	5	0	9
22	R:R:I395	4.25	4	0	6
23	L:L:?1	9.13571	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V366	R:R:Y370	34.2485	6.31	No	Yes	1	6	8
2	R:R:F340	R:R:V366	32.2001	3.93	Yes	No	1	7	6
3	R:R:F340	R:R:F341	93.1454	5.36	Yes	Yes	1	7	7
4	R:R:F226	R:R:F341	93.1209	18.22	Yes	Yes	1	8	7
5	R:R:F226	R:R:F333	99.5903	3.22	Yes	No	0	8	9
6	R:R:F333	R:R:I143	100	3.77	No	No	0	9	8
7	R:R:I143	R:R:P229	99.9266	3.39	No	No	0	8	9
8	R:R:P229	R:R:W144	99.7432	8.11	No	No	0	9	6
9	R:R:I182	R:R:W144	99.6331	10.57	No	No	0	5	6
10	R:R:I182	R:R:I186	99.3763	2.94	No	No	0	5	6
11	R:R:I186	R:R:T140	99.0706	3.04	No	No	0	6	7
12	R:R:S183	R:R:T140	98.7159	6.4	No	No	0	8	7
13	R:R:A141	R:R:S183	87.7339	3.42	No	No	0	8	8
14	R:R:A141	R:R:H145	83.5637	2.93	No	Yes	2	8	8
15	R:R:H145	R:R:L96	83.2273	9	Yes	No	0	8	9
16	R:R:D100	R:R:L96	82.8177	4.07	Yes	No	0	9	9
17	R:R:D100	R:R:N72	59.0253	4.04	Yes	Yes	0	9	9
18	R:R:L137	R:R:S183	12.26	3	No	No	0	6	8
19	R:R:F138	R:R:L137	10.4256	3.65	Yes	No	0	6	6
20	R:R:N72	R:R:P377	51.8589	9.77	Yes	No	0	9	9
21	R:R:A78	R:R:F391	10.7374	2.77	No	No	0	8	7
22	R:R:A78	R:R:F387	12.2233	2.77	No	Yes	0	8	9
23	R:R:F387	R:R:T381	42.644	9.08	Yes	No	0	9	7
24	R:R:L382	R:R:T381	46.2028	2.95	No	No	0	6	7
25	R:R:L378	R:R:L382	49.6331	2.77	No	No	0	6	6
26	R:R:L378	R:R:P377	50.7521	3.28	No	No	0	6	9
27	R:R:F387	R:R:N90	20.6188	6.04	Yes	No	0	9	9
28	R:R:N90	R:R:Y87	17.91	15.12	No	No	0	9	7
29	R:R:T89	R:R:Y87	16.473	2.5	No	No	0	8	7
30	R:R:N167	R:R:T89	15.0177	1.46	No	No	0	7	8
31	R:R:A88	R:R:N167	12.2172	4.69	No	No	0	6	7
32	R:R:A88	R:R:R169	10.7374	1.38	No	Yes	0	6	4
33	R:R:D100	R:R:N376	50.7643	8.08	Yes	No	0	9	9
34	R:R:V107	R:R:Y370	19.671	3.79	No	Yes	1	7	8
35	R:R:V107	R:R:W131	39.8924	6.13	No	No	0	7	6
36	R:R:L113	R:R:L123	12.0704	1.38	No	Yes	0	5	6
37	R:R:L123	R:R:W121	21.6033	4.56	Yes	Yes	3	6	7
38	R:R:W121	R:R:W131	35.4837	4.69	Yes	No	0	7	6
39	R:R:N201	R:R:P202	14.7915	1.63	Yes	No	0	2	3
40	R:R:I205	R:R:P202	17.6043	1.69	No	No	0	2	3
41	R:R:I195	R:R:I205	20.3375	1.47	No	No	0	5	2
42	R:R:I195	R:R:L132	21.536	2.85	No	No	0	5	5
43	R:R:L132	R:R:V190	31.7537	4.47	No	No	0	5	6
44	R:R:F217	R:R:V190	36.6271	3.93	No	No	0	7	6
45	L:L:?1	R:R:F217	38.9079	2.86	Yes	No	0	0	7
46	L:L:?1	R:R:D135	26.4339	18.04	Yes	Yes	1	0	8
47	R:R:L146	R:R:N376	46.215	4.12	No	No	0	9	9
48	R:R:L146	R:R:Y380	45.0165	8.21	No	Yes	0	9	9
49	R:R:F333	R:R:M233	19.1452	8.71	No	No	0	9	8
50	R:R:R153	R:R:Y380	37.5749	6.17	No	Yes	4	9	9
51	R:R:L326	R:R:R153	36.6027	4.86	No	No	0	8	9
52	R:R:L326	R:R:T240	35.4714	1.47	No	No	0	8	9
53	R:R:T240	R:R:Y154	34.1996	6.24	No	No	0	9	8
54	R:R:K158	R:R:Y154	30.2923	7.17	No	No	0	7	8
55	R:R:A243	R:R:I157	19.3347	1.62	No	No	0	6	9
56	R:R:A243	R:R:K158	20.7472	1.61	No	No	0	6	7
57	R:R:I157	R:R:L244	17.91	7.14	No	No	0	9	8
58	R:R:L132	R:R:L209	10.2727	5.54	No	No	0	5	5
59	R:R:C338	R:R:F226	21.9457	4.19	No	Yes	0	6	8
60	R:R:C338	R:R:I342	19.243	1.64	No	No	0	6	6
61	R:R:I342	R:R:T346	17.8244	1.52	No	No	0	6	5
62	R:R:C353	R:R:T346	13.3851	1.69	No	No	6	4	5
63	R:R:C353	R:R:L358	12.0276	1.59	No	No	0	4	4
64	R:R:F330	R:R:M233	10.6824	3.73	No	No	0	8	8
65	R:R:E319	R:R:L244	15.1584	5.3	No	No	0	8	8
66	R:R:E319	R:R:K247	12.2111	4.05	No	No	0	8	7
67	R:R:K247	R:R:S317	10.7313	7.65	No	No	0	7	4
68	L:L:?1	R:R:F340	58.7379	15.23	Yes	Yes	1	0	7
69	R:R:D135	R:R:V107	22.496	2.92	Yes	No	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D135	R:R:V107	2.92	1	Yes	No	8	7	1	2
R:R:V107	R:R:Y370	3.79	1	No	Yes	7	8	2	2
R:R:D135	R:R:S139	4.42	1	Yes	No	8	7	1	1
R:R:D135	R:R:Y370	10.34	1	Yes	Yes	8	8	1	2
L:L:?1	R:R:D135	18.04	1	Yes	Yes	0	8	0	1
R:R:A187	R:R:V136	3.39	0	No	No	8	7	2	1
L:L:?1	R:R:V136	15.14	1	Yes	No	0	7	0	1
L:L:?1	R:R:S139	5.87	1	Yes	No	0	7	0	1
R:R:F217	R:R:V190	3.93	0	No	No	7	6	1	2
R:R:F217	R:R:G221	3.01	0	No	No	7	6	1	2
L:L:?1	R:R:F217	2.86	1	Yes	No	0	7	0	1
R:R:M218	R:R:N344	7.01	0	No	No	6	6	2	1
R:R:F340	R:R:F341	5.36	1	Yes	Yes	7	7	1	2
R:R:F340	R:R:L362	4.87	1	Yes	No	7	5	1	2
R:R:F340	R:R:V366	3.93	1	Yes	No	7	6	1	1
L:L:?1	R:R:F340	15.23	1	Yes	Yes	0	7	0	1
R:R:V366	R:R:Y370	6.31	1	No	Yes	6	8	1	2
L:L:?1	R:R:V366	4.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:N344	2.15	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7SRR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	255
Number of Links	263
Number of Hubs	23
Number of Links mediated by Hubs	96
Number of Communities	6
Number of Nodes involved in Communities	31
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	31485
Length Of Smallest Path	3
Average Path Length	18.4435
Length of Longest Path	45
Minimum Path Strength	1.3
Average Path Strength	5.54714
Maximum Path Strength	16.635
Minimum Path Correlation	0.7
Average Path Correlation	0.930553
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	52.0154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	27.1343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyllysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41595
Sequence	>7SRR_nogp_Chain_R W A A L L I L M V I I P T I G G N T L V I L A V S L E K K L Q Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F E A M W P L P L V L C P A W L F L D V L F S T A S I W H L C A I S V D R Y I A I K K P I Q A N Q Y N S R A T A F I K I T V V W L I S I G I A I P V P I K G I E T D V D N P N N I T C V L T K E R F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C D S C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F R D A F G R Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7SRQ	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	-	2.7	2022-09-21	10.1016/j.neuron.2022.08.006
	7SRS	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	Arrestin2	3.3	2022-09-21	10.1016/j.neuron.2022.08.006
	7SRR	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2022-09-21	10.1016/j.neuron.2022.08.006
	7SRR (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-		2.9	2022-09-21	10.1016/j.neuron.2022.08.006
	6DS0	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ly266097	-	-	3.19	2018-08-29	10.1038/s41594-018-0116-7
	6DRZ	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Methysergide	-	-	3.1	2018-08-29	10.1038/s41594-018-0116-7
	6DRY	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Methylergonovine	-	-	2.92	2018-08-29	10.1038/s41594-018-0116-7
	6DRX	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Lisuride	-	-	3.1	2018-08-29	10.1038/s41594-018-0116-7
	5TUD	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	3	2017-07-26	10.1073/pnas.1700891114
	5TVN	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	LSD	-	-	2.9	2017-02-01	10.1016/j.cell.2016.12.033
	4NC3	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	2.8	2013-12-18	10.1126/science.1244142
	4IB4	A	Amine	5-Hydroxytryptamine	5-HT_2B	Homo sapiens	Ergotamine	-	-	2.7	2013-03-13	10.1126/science.1232808

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SRR_nogp.zip

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