psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:Y1	6.95	Yes	Yes	2	0	0
2	L:L:Y1	R:R:M153	4.79	Yes	Yes	2	0	7
3	L:L:Y1	R:R:K235	2.39	Yes	Yes	2	0	4
4	L:L:Y1	R:R:V238	10.09	Yes	No	2	0	5
5	L:L:Y1	R:R:V302	5.05	Yes	Yes	2	0	5
6	L:L:P2	R:R:I298	6.77	Yes	Yes	2	0	6
7	L:L:P2	R:R:V302	3.53	Yes	Yes	2	0	5
8	L:L:P2	R:R:W320	6.76	Yes	Yes	2	0	4
9	L:L:P2	R:R:I324	6.77	Yes	Yes	2	0	5
10	L:L:?5	L:L:W3	14.09	No	Yes	0	0	0
11	L:L:W3	R:R:Q126	10.95	Yes	Yes	2	0	6
12	L:L:W3	R:R:N129	3.39	Yes	No	2	0	4
13	L:L:W3	R:R:W135	5.62	Yes	Yes	2	0	8
14	L:L:W3	R:R:V145	4.9	Yes	Yes	2	0	5
15	L:L:W3	R:R:I146	7.05	Yes	Yes	2	0	4
16	L:L:W3	R:R:C219	7.84	Yes	Yes	2	0	9
17	L:L:?5	L:L:F4	12.06	No	Yes	0	0	0
18	L:L:F4	R:R:Y77	11.35	Yes	Yes	2	0	7
19	L:L:F4	R:R:Q126	9.37	Yes	Yes	2	0	6
20	L:L:F4	R:R:Y130	8.25	Yes	Yes	2	0	5
21	L:L:F4	R:R:W320	2	Yes	Yes	2	0	4
22	L:L:F4	R:R:H321	10.18	Yes	Yes	2	0	4
23	L:L:F4	R:R:I324	5.02	Yes	Yes	2	0	5
24	R:R:M67	R:R:T69	3.01	No	No	0	2	4
25	R:R:T314	R:R:T69	4.71	No	No	0	1	4
26	R:R:I71	R:R:M74	2.92	No	Yes	0	5	5
27	R:R:I73	R:R:Y77	3.63	Yes	Yes	2	6	7
28	R:R:I73	R:R:Y130	7.25	Yes	Yes	2	6	5
29	R:R:H321	R:R:I73	15.91	Yes	Yes	2	4	6
30	R:R:M74	R:R:S127	6.13	Yes	No	0	5	6
31	R:R:L131	R:R:M74	8.48	No	Yes	0	4	5
32	R:R:I79	R:R:L76	2.85	No	No	0	4	5
33	R:R:A325	R:R:L76	3.15	No	No	0	6	5
34	R:R:L123	R:R:Y77	2.34	Yes	Yes	2	7	7
35	R:R:S127	R:R:Y77	5.09	No	Yes	0	6	7
36	R:R:H321	R:R:Y77	7.62	Yes	Yes	2	4	7
37	R:R:I324	R:R:Y77	7.25	Yes	Yes	2	5	7
38	R:R:A325	R:R:Y77	2.67	No	Yes	0	6	7
39	R:R:C332	R:R:V80	1.71	No	No	0	8	7
40	R:R:C81	R:R:L85	3.17	Yes	No	0	6	6
41	R:R:C81	R:R:T120	3.38	Yes	No	0	6	5
42	R:R:C81	R:R:L123	6.35	Yes	Yes	2	6	7
43	R:R:C81	R:R:P124	3.77	Yes	No	2	6	8
44	R:R:G84	R:R:V83	1.84	No	No	0	8	5
45	R:R:G84	R:R:N88	1.7	No	Yes	0	8	9
46	R:R:C332	R:R:G84	3.92	No	No	0	8	8
47	R:R:F89	R:R:L85	3.65	No	No	0	4	6
48	R:R:F86	R:R:L90	9.74	No	No	0	5	6
49	R:R:G87	R:R:L90	1.71	No	No	0	8	6
50	R:R:D116	R:R:N88	4.04	Yes	Yes	2	9	9
51	R:R:A117	R:R:N88	4.69	No	Yes	0	7	9
52	R:R:N88	R:R:P335	4.89	Yes	No	2	9	9
53	R:R:A113	R:R:V91	1.7	No	No	0	9	9
54	R:R:A339	R:R:V91	3.39	No	No	11	6	9
55	R:R:F345	R:R:V91	2.62	Yes	No	11	8	9
56	R:R:F110	R:R:M92	4.98	No	No	0	6	7
57	R:R:A113	R:R:M92	3.22	No	No	0	9	7
58	R:R:L114	R:R:M92	5.65	No	No	0	7	7
59	R:R:F345	R:R:V94	7.87	Yes	No	0	8	7
60	R:R:C348	R:R:V94	1.71	Yes	No	0	6	7
61	R:R:I95	R:R:M101	2.92	No	No	12	7	7
62	R:R:I95	R:R:N106	2.83	No	No	0	7	8
63	R:R:F110	R:R:I95	3.77	No	No	12	6	7
64	R:R:R97	R:R:Y98	10.29	No	No	0	5	4
65	R:R:C348	R:R:Y98	2.69	Yes	No	0	6	4
66	R:R:F352	R:R:Y98	10.32	No	No	0	7	4
67	R:R:N106	R:R:T99	5.85	No	No	0	8	6
68	R:R:C348	R:R:T99	5.07	Yes	No	0	6	6
69	R:R:K100	R:R:K102	8.62	No	No	0	6	7
70	R:R:F110	R:R:M101	3.73	No	No	12	6	7
71	R:R:T103	R:R:T105	3.14	No	No	15	7	8
72	R:R:N106	R:R:T103	7.31	No	No	0	8	7
73	R:R:T103	V:V:D69	4.34	No	Yes	15	7	9
74	R:R:A104	R:R:A186	1.79	No	No	0	5	7
75	R:R:T105	V:V:D69	17.34	No	Yes	15	8	9
76	R:R:I107	R:R:K187	7.27	No	No	0	5	2
77	R:R:I107	R:R:N190	4.25	No	No	0	5	7
78	R:R:T162	R:R:Y108	2.5	No	Yes	2	7	7
79	R:R:M163	R:R:Y108	5.99	Yes	Yes	2	9	7
80	R:R:D166	R:R:Y108	13.79	No	Yes	0	8	7
81	R:R:A186	R:R:Y108	4	No	Yes	0	7	7
82	R:R:V189	R:R:Y108	5.05	No	Yes	2	5	7
83	R:R:N190	R:R:Y108	8.14	No	Yes	0	7	7
84	R:R:N111	R:R:T159	8.77	No	No	0	9	8
85	R:R:N111	R:R:N190	10.9	No	No	0	9	7
86	R:R:N111	R:R:W194	14.69	No	Yes	0	9	9
87	R:R:D116	R:R:L112	5.43	Yes	Yes	2	9	9
88	R:R:L112	R:R:S156	3	Yes	No	2	9	9
89	R:R:L112	R:R:M163	5.65	Yes	Yes	2	9	9
90	R:R:L112	R:R:N334	5.49	Yes	Yes	2	9	9
91	R:R:L112	R:R:Y338	4.69	Yes	Yes	2	9	9
92	R:R:L114	R:R:L118	4.15	No	No	0	7	7
93	R:R:L114	R:R:W194	4.56	No	Yes	0	7	9
94	R:R:A115	R:R:T155	3.36	No	Yes	2	8	7
95	R:R:A115	R:R:S156	1.71	No	No	2	8	9
96	R:R:A115	R:R:W194	2.59	No	Yes	2	8	9
97	R:R:D116	R:R:S156	7.36	Yes	No	2	9	9
98	R:R:D116	R:R:S331	10.31	Yes	No	0	9	9
99	R:R:D116	R:R:N334	6.73	Yes	Yes	2	9	9
100	R:R:D116	R:R:P335	4.83	Yes	No	2	9	9
101	R:R:L118	R:R:N152	13.73	No	Yes	0	7	8
102	R:R:T120	R:R:Y328	3.75	No	Yes	0	5	7
103	R:R:S331	R:R:T120	4.8	No	No	0	9	5
104	R:R:Q126	R:R:T122	4.25	Yes	Yes	2	6	6
105	R:R:T122	R:R:V145	3.17	Yes	Yes	2	6	5
106	R:R:I148	R:R:T122	3.04	No	Yes	0	5	6
107	R:R:D149	R:R:T122	2.89	No	Yes	2	5	6
108	R:R:L123	R:R:P124	1.64	Yes	No	2	7	8
109	R:R:L123	R:R:Y328	14.07	Yes	Yes	0	7	7
110	R:R:F125	R:R:W135	6.01	Yes	Yes	2	6	8
111	R:R:F125	R:R:F137	15	Yes	Yes	2	6	6
112	R:R:F125	R:R:L141	2.44	Yes	No	2	6	5
113	R:R:F125	R:R:V145	7.87	Yes	Yes	2	6	5
114	R:R:D149	R:R:Q126	2.61	No	Yes	2	5	6
115	R:R:F137	R:R:V128	2.62	Yes	No	0	6	3
116	R:R:N129	R:R:W135	9.04	No	Yes	2	4	8
117	R:R:T317	R:R:Y130	3.75	No	Yes	2	4	5
118	R:R:H321	R:R:Y130	18.51	Yes	Yes	2	4	5
119	R:R:L131	R:R:M132	4.24	No	No	0	4	4
120	R:R:M132	R:R:P136	1.68	No	No	0	4	3
121	R:R:G133	R:R:T134	1.82	No	Yes	0	2	5
122	R:R:P136	R:R:T134	1.75	No	Yes	0	3	5
123	R:R:S216	R:R:T134	3.2	No	Yes	0	1	5
124	R:R:I217	R:R:T134	3.04	No	Yes	0	4	5
125	R:R:F137	R:R:W135	20.04	Yes	Yes	2	6	8
126	R:R:G138	R:R:W135	2.81	No	Yes	0	7	8
127	R:R:L141	R:R:W135	2.28	No	Yes	2	5	8
128	R:R:C142	R:R:W135	5.22	No	Yes	2	9	8
129	R:R:V145	R:R:W135	4.9	Yes	Yes	2	5	8
130	R:R:C219	R:R:W135	11.75	Yes	Yes	2	9	8
131	R:R:F137	R:R:P136	5.78	Yes	No	0	6	3
132	R:R:F137	R:R:L141	6.09	Yes	No	2	6	5
133	R:R:I140	R:R:N139	7.08	No	No	0	1	3
134	R:R:K143	R:R:N139	9.79	No	No	0	6	3
135	R:R:C142	R:R:T210	1.69	No	No	0	9	4
136	R:R:C142	R:R:C219	7.28	No	Yes	2	9	9
137	R:R:A208	R:R:K143	3.21	No	No	0	5	6
138	R:R:K143	R:R:T209	3	No	No	0	6	5
139	R:R:I146	R:R:Y150	2.42	Yes	No	2	4	4
140	R:R:I146	R:R:V204	3.07	Yes	Yes	2	4	5
141	R:R:A208	R:R:I146	3.25	No	Yes	0	5	4
142	R:R:C219	R:R:I146	3.27	Yes	Yes	2	9	4
143	R:R:M205	R:R:S147	7.67	No	No	0	5	6
144	R:R:I148	R:R:N152	7.08	No	Yes	0	5	8
145	R:R:D149	R:R:Y328	4.6	No	Yes	0	5	7
146	R:R:V204	R:R:Y150	5.05	Yes	No	2	5	4
147	R:R:L234	R:R:Y150	2.34	No	No	0	6	4
148	R:R:T155	R:R:Y151	4.99	Yes	Yes	2	7	5
149	R:R:W194	R:R:Y151	12.54	Yes	Yes	2	9	5
150	R:R:S197	R:R:Y151	6.36	No	Yes	2	8	5
151	R:R:S198	R:R:Y151	3.82	No	Yes	0	4	5
152	R:R:N152	R:R:W194	2.26	Yes	Yes	0	8	9
153	R:R:F154	R:R:M153	6.22	Yes	Yes	2	6	7
154	R:R:I157	R:R:M153	2.92	Yes	Yes	2	7	7
155	R:R:M153	R:R:W295	2.33	Yes	Yes	2	7	8
156	R:R:F154	R:R:S197	3.96	Yes	No	2	6	8
157	R:R:F154	R:R:I200	11.3	Yes	No	0	6	5
158	R:R:F154	R:R:V238	6.55	Yes	No	2	6	5
159	R:R:A242	R:R:F154	4.16	No	Yes	2	5	6
160	R:R:T155	R:R:W194	14.55	Yes	Yes	2	7	9
161	R:R:S197	R:R:T155	4.8	No	Yes	2	8	7
162	R:R:C161	R:R:I157	1.64	Yes	Yes	2	7	7
163	R:R:I157	R:R:P246	3.39	Yes	No	2	7	8
164	R:R:F291	R:R:I157	2.51	Yes	Yes	2	9	7
165	R:R:I157	R:R:W295	7.05	Yes	Yes	2	7	8
166	R:R:F158	R:R:N193	6.04	No	No	0	5	7
167	R:R:F158	R:R:L196	3.65	No	No	0	5	4
168	R:R:M163	R:R:T159	4.52	Yes	No	0	9	8
169	R:R:N193	R:R:T159	4.39	No	No	0	7	8
170	R:R:L160	R:R:M163	2.83	Yes	Yes	2	8	9
171	R:R:F291	R:R:L160	2.44	Yes	Yes	2	9	8
172	R:R:L160	R:R:N334	8.24	Yes	Yes	2	8	9
173	R:R:L160	R:R:Y338	4.69	Yes	Yes	2	8	9
174	R:R:C161	R:R:S164	1.72	Yes	No	0	7	9
175	R:R:C161	R:R:P246	3.77	Yes	No	2	7	8
176	R:R:C161	R:R:I249	1.64	Yes	No	0	7	6
177	R:R:T162	R:R:V189	3.17	No	No	2	7	5
178	R:R:N193	R:R:T162	4.39	No	No	0	7	7
179	R:R:M163	R:R:Y338	5.99	Yes	Yes	2	9	9
180	R:R:I250	R:R:S164	3.1	No	No	0	8	9
181	R:R:C253	R:R:S164	3.44	Yes	No	0	8	9
182	R:R:C253	R:R:V165	3.42	Yes	No	0	8	6
183	R:R:D166	R:R:R181	13.1	No	Yes	0	8	7
184	R:R:R167	R:R:Y254	3.09	Yes	Yes	2	9	9
185	R:R:M257	R:R:R167	2.48	Yes	Yes	2	8	9
186	R:R:R167	R:R:Y338	3.09	Yes	Yes	2	9	9
187	R:R:R167	V:V:L71	4.86	Yes	Yes	0	9	8
188	R:R:I169	R:R:Y168	2.42	No	Yes	0	5	8
189	R:R:C172	R:R:Y168	6.72	No	Yes	0	7	8
190	R:R:H173	R:R:Y168	4.36	No	Yes	0	6	8
191	R:R:C253	R:R:Y168	6.72	Yes	Yes	0	8	8
192	R:R:L256	R:R:Y168	8.21	No	Yes	0	5	8
193	R:R:M257	R:R:Y168	2.39	Yes	Yes	0	8	8
194	R:R:A170	R:R:A177	1.79	No	No	6	8	6
195	R:R:A170	R:R:R181	5.53	No	Yes	6	8	7
196	R:R:A170	V:V:V70	1.7	No	Yes	6	8	7
197	R:R:M257	R:R:V171	6.09	Yes	No	0	8	8
198	R:R:L261	R:R:V171	2.98	No	No	0	8	8
199	R:R:C172	R:R:R260	5.57	No	No	0	7	5
200	R:R:P174	V:V:L243	1.64	No	No	0	8	7
201	R:R:V175	V:V:I241	7.68	No	Yes	0	6	7
202	R:R:V175	V:V:A247	3.39	No	No	0	6	6
203	R:R:A177	R:R:R181	2.77	No	Yes	6	6	7
204	R:R:L178	V:V:R285	2.43	No	Yes	0	4	5
205	R:R:L178	V:V:G286	1.71	No	No	0	4	7
206	R:R:R181	V:V:V70	3.92	Yes	Yes	6	7	7
207	R:R:P183	R:R:T182	3.5	No	No	0	1	7
208	R:R:N185	R:R:T182	5.85	No	No	0	4	7
209	R:R:T182	V:V:R285	6.47	No	Yes	0	7	5
210	R:R:I188	R:R:R184	7.52	No	No	0	3	3
211	R:R:I195	R:R:V191	3.07	No	No	0	4	4
212	R:R:L202	R:R:S198	4.5	No	No	0	4	4
213	R:R:G201	R:R:I200	1.76	No	No	0	6	5
214	R:R:G201	R:R:V204	1.84	No	Yes	0	6	5
215	R:R:L202	R:R:P203	1.64	No	No	0	4	8
216	R:R:F206	R:R:L202	4.87	No	No	0	4	4
217	R:R:M207	R:R:P203	1.68	No	No	0	5	8
218	R:R:L221	R:R:M207	7.07	No	No	0	4	5
219	R:R:T209	R:R:T222	6.28	No	No	0	5	4
220	R:R:K211	R:R:T220	3	No	No	0	1	4
221	R:R:K211	R:R:T222	6.01	No	No	0	1	4
222	R:R:I217	R:R:Y212	2.42	No	No	0	4	3
223	R:R:Q214	R:R:R213	5.84	No	No	0	2	2
224	R:R:R213	R:R:S216	5.27	No	No	0	2	1
225	R:R:D218	R:R:R213	4.76	No	No	0	4	2
226	R:R:G215	R:R:S216	1.86	No	No	0	5	1
227	R:R:E231	R:R:L221	2.65	No	No	0	4	4
228	R:R:F223	R:R:H225	9.05	Yes	No	9	6	2
229	R:R:F223	R:R:T227	5.19	Yes	No	9	6	3
230	R:R:F223	R:R:W230	28.06	Yes	Yes	9	6	1
231	R:R:E231	R:R:F223	4.66	No	Yes	9	4	6
232	R:R:H225	R:R:P226	3.05	No	No	0	2	4
233	R:R:H225	R:R:W230	15.87	No	Yes	9	2	1
234	R:R:E231	R:R:T227	4.23	No	No	9	4	3
235	R:R:N232	R:R:W228	2.26	No	No	0	2	1
236	R:R:W230	R:R:Y229	5.79	Yes	No	0	1	1
237	R:R:K235	R:R:V302	6.07	Yes	Yes	2	4	5
238	R:R:A306	R:R:K235	4.82	No	Yes	0	4	4
239	R:R:F239	R:R:I236	2.51	Yes	No	0	6	4
240	R:R:A242	R:R:V238	1.7	No	No	2	5	5
241	R:R:F239	R:R:F243	7.5	Yes	Yes	2	6	8
242	R:R:F239	R:R:I244	3.77	Yes	No	2	6	4
243	R:R:F239	R:R:H299	5.66	Yes	No	2	6	7
244	R:R:F239	R:R:I303	8.79	Yes	No	0	6	5
245	R:R:F241	R:R:I240	6.28	No	No	0	4	5
246	R:R:I240	R:R:I244	7.36	No	No	0	5	4
247	R:R:F243	R:R:I244	3.77	Yes	No	2	8	4
248	R:R:F243	R:R:T296	6.49	Yes	No	0	8	5
249	R:R:F243	R:R:H299	11.31	Yes	No	2	8	7
250	R:R:M245	R:R:P246	10.06	No	No	0	5	8
251	R:R:I249	R:R:M245	2.92	No	No	0	6	5
252	R:R:C253	R:R:I249	1.64	Yes	No	0	8	6
253	R:R:I250	R:R:Y254	2.42	No	Yes	0	8	9
254	R:R:F291	R:R:I250	2.51	Yes	No	0	9	8
255	R:R:M257	R:R:Y254	2.39	Yes	Yes	2	8	9
256	R:R:V284	R:R:Y254	8.83	No	Yes	0	8	9
257	R:R:V287	R:R:Y254	3.79	No	Yes	2	8	9
258	R:R:V288	R:R:Y254	5.05	No	Yes	0	8	9
259	R:R:Y254	R:R:Y338	2.98	Yes	Yes	2	9	9
260	R:R:G255	R:R:I258	3.53	No	No	17	3	5
261	R:R:G255	R:R:L259	1.71	No	No	17	3	2
262	R:R:I258	R:R:L259	2.85	No	No	17	5	2
263	R:R:R260	R:R:S263	2.64	No	No	16	5	3
264	R:R:R260	V:V:F244	6.41	No	No	16	5	7
265	R:R:L261	R:R:L277	2.77	No	No	0	8	6
266	R:R:I280	R:R:L261	2.85	No	No	0	8	8
267	R:R:S263	V:V:F244	10.57	No	No	16	3	7
268	R:R:E272	R:R:N276	9.2	No	No	0	3	5
269	R:R:K273	R:R:N276	5.6	No	No	0	3	5
270	R:R:K273	R:R:L277	2.82	No	No	0	3	6
271	R:R:R275	R:R:R282	8.53	No	No	0	4	5
272	R:R:E343	R:R:R279	2.33	No	No	0	5	7
273	R:R:I280	V:V:L71	7.14	No	Yes	0	8	8
274	R:R:L285	R:R:T281	2.95	No	No	0	5	6
275	R:R:L341	R:R:M283	2.83	No	No	0	7	8
276	R:R:M283	V:V:L71	2.83	No	Yes	0	8	8
277	R:R:V284	V:V:L71	2.98	No	Yes	0	8	8
278	R:R:V287	R:R:Y338	3.79	No	Yes	2	8	9
279	R:R:C294	R:R:V290	1.71	No	Yes	2	9	7
280	R:R:N330	R:R:V290	2.96	Yes	Yes	2	9	7
281	R:R:L333	R:R:V290	4.47	No	Yes	0	6	7
282	R:R:F291	R:R:W295	11.02	Yes	Yes	2	9	8
283	R:R:F291	R:R:N330	4.83	Yes	Yes	2	9	9
284	R:R:C294	R:R:L326	6.35	No	No	0	9	8
285	R:R:C294	R:R:N330	11.02	No	Yes	2	9	9
286	R:R:I298	R:R:W295	2.35	Yes	Yes	2	6	8
287	R:R:H299	R:R:W295	2.12	No	Yes	2	7	8
288	R:R:N330	R:R:W295	6.78	Yes	Yes	2	9	8
289	R:R:P297	R:R:T296	5.25	No	No	0	9	5
290	R:R:I300	R:R:T296	3.04	No	No	0	6	5
291	R:R:C323	R:R:P297	1.88	No	No	0	6	9
292	R:R:L326	R:R:P297	1.64	No	No	0	8	9
293	R:R:I298	R:R:V302	3.07	Yes	Yes	2	6	5
294	R:R:C323	R:R:I298	3.27	No	Yes	0	6	6
295	R:R:I310	R:R:Y301	4.84	Yes	Yes	2	4	5
296	R:R:Q316	R:R:Y301	9.02	Yes	Yes	2	3	5
297	R:R:S319	R:R:Y301	5.09	No	Yes	0	4	5
298	R:R:W320	R:R:Y301	8.68	Yes	Yes	2	4	5
299	R:R:C323	R:R:Y301	2.69	No	Yes	0	6	5
300	R:R:V302	R:R:W320	2.45	Yes	Yes	2	5	4
301	R:R:I310	R:R:K305	2.91	Yes	No	2	4	3
302	R:R:K305	R:R:Q316	4.07	No	Yes	2	3	3
303	R:R:K305	R:R:W320	5.8	No	Yes	2	3	4
304	R:R:I310	R:R:P311	5.08	Yes	No	0	4	1
305	R:R:I310	R:R:Q316	8.23	Yes	Yes	2	4	3
306	R:R:H321	R:R:T317	2.74	Yes	No	2	4	4
307	R:R:H321	R:R:W320	5.29	Yes	Yes	2	4	4
308	R:R:I324	R:R:W320	2.35	Yes	Yes	2	5	4
309	R:R:I324	R:R:Y328	2.42	Yes	Yes	0	5	7
310	R:R:L326	R:R:T329	4.42	No	No	0	8	5
311	R:R:L333	R:R:T329	2.95	No	No	0	6	5
312	R:R:N330	R:R:N334	10.9	Yes	Yes	2	9	9
313	R:R:L333	R:R:V336	4.47	No	No	0	6	6
314	R:R:N334	R:R:Y338	2.33	Yes	Yes	2	9	9
315	R:R:A339	R:R:F345	6.93	No	Yes	11	6	8
316	R:R:F340	R:R:F345	9.65	No	Yes	0	6	8
317	R:R:K346	R:R:L341	2.82	No	No	0	8	7
318	R:R:D342	R:R:F345	3.58	No	Yes	0	8	8
319	R:R:D342	V:V:D69	5.32	No	Yes	0	8	9
320	R:R:E343	V:V:L68	2.65	No	No	6	5	7
321	R:R:E343	V:V:G72	1.64	No	No	6	5	9
322	R:R:N344	R:R:R347	9.64	No	No	0	7	5
323	R:R:N344	V:V:D69	4.04	No	Yes	0	7	9
324	R:R:C348	R:R:R347	4.18	Yes	No	13	6	5
325	R:R:E351	R:R:R347	5.82	No	No	13	3	5
326	R:R:C348	R:R:E351	3.04	Yes	No	13	6	3
327	R:R:F349	R:R:F352	3.22	No	No	14	6	7
328	R:R:C353	R:R:F349	5.59	No	No	14	5	6
329	R:R:C353	R:R:F352	2.79	No	No	14	5	7
330	R:R:?366	R:R:E365	2.25	Yes	Yes	3	6	3
331	R:R:E365	V:V:P14	9.43	Yes	No	3	3	4
332	R:R:E365	V:V:K160	2.7	Yes	No	0	3	6
333	R:R:E365	V:V:R161	3.49	Yes	Yes	3	3	7
334	R:R:?366	R:R:C367	2.7	Yes	No	3	6	5
335	R:R:?366	R:R:?368	1.93	Yes	Yes	3	6	4
336	R:R:?366	V:V:K11	4.8	Yes	Yes	3	6	9
337	R:R:?366	V:V:R165	12.4	Yes	No	0	6	5
338	R:R:?368	R:R:C367	5.21	Yes	No	3	4	5
339	R:R:?368	R:R:?369	20.53	Yes	Yes	3	4	6
340	R:R:?368	V:V:K11	3.47	Yes	Yes	3	4	9
341	R:R:?369	R:R:A370	2.59	Yes	No	0	6	7
342	R:R:?369	V:V:K11	13.89	Yes	Yes	3	6	9
343	R:R:?369	V:V:R25	11.97	Yes	Yes	3	6	9
344	R:R:?369	V:V:L166	2.27	Yes	No	3	6	8
345	R:R:?369	V:V:K294	8.11	Yes	No	0	6	8
346	R:R:?371	R:R:A370	4.02	Yes	No	0	4	7
347	R:R:?371	R:R:?372	17.02	Yes	Yes	4	4	7
348	R:R:?371	V:V:R7	19.63	Yes	No	4	4	5
349	R:R:?371	V:V:K10	8.39	Yes	No	4	4	9
350	R:R:?372	R:R:?373	28.03	Yes	Yes	4	7	5
351	R:R:?372	V:V:R7	17.56	Yes	No	4	7	5
352	R:R:?372	V:V:V8	3.8	Yes	No	0	7	7
353	R:R:?372	V:V:K10	10.79	Yes	No	4	7	9
354	R:R:?372	V:V:Y21	2.99	Yes	Yes	4	7	8
355	R:R:?372	V:V:K107	9.59	Yes	Yes	4	7	9
356	R:R:?373	R:R:L374	5.89	Yes	Yes	4	5	5
357	R:R:?373	V:V:R7	12.4	Yes	No	4	5	5
358	R:R:?373	V:V:K107	6	Yes	Yes	4	5	9
359	R:R:L374	V:V:T6	7.37	Yes	No	4	5	5
360	R:R:L374	V:V:R103	14.58	Yes	Yes	4	5	5
361	R:R:L374	V:V:L104	2.77	Yes	No	0	5	9
362	R:R:L374	V:V:K107	2.82	Yes	Yes	4	5	9
363	R:R:K376	V:V:T6	7.51	No	No	4	5	5
364	R:R:K376	V:V:R103	2.48	No	Yes	4	5	5
365	V:V:R103	V:V:T6	11.64	Yes	No	4	5	5
366	V:V:G23	V:V:V8	3.68	No	No	0	5	7
367	V:V:F9	V:V:R25	7.48	No	Yes	0	7	9
368	V:V:K10	V:V:Y21	10.75	No	Yes	4	9	8
369	V:V:K11	V:V:L166	11.28	Yes	No	3	9	8
370	V:V:A12	V:V:T19	3.36	No	No	0	5	6
371	V:V:P14	V:V:S13	3.56	No	Yes	3	4	8
372	V:V:N15	V:V:S13	10.43	Yes	Yes	3	9	8
373	V:V:G16	V:V:S13	1.86	No	Yes	3	4	8
374	V:V:L18	V:V:S13	6.01	No	Yes	0	5	8
375	V:V:P14	V:V:R161	2.88	No	Yes	3	4	7
376	V:V:G16	V:V:N15	1.7	No	Yes	3	4	9
377	V:V:K17	V:V:N15	6.99	No	Yes	3	6	9
378	V:V:N15	V:V:Y47	2.33	Yes	Yes	3	9	5
379	V:V:N15	V:V:R161	3.62	Yes	Yes	3	9	7
380	V:V:N15	V:V:N162	10.9	Yes	Yes	3	9	8
381	V:V:D44	V:V:K17	4.15	No	No	3	7	6
382	V:V:K17	V:V:Y47	10.75	No	Yes	3	6	5
383	V:V:C150	V:V:L18	4.76	No	No	0	5	5
384	V:V:T19	V:V:Y21	4.99	No	Yes	4	6	8
385	V:V:L42	V:V:T19	4.42	No	No	4	4	6
386	V:V:V20	V:V:V41	3.21	No	No	0	5	4
387	V:V:F115	V:V:V20	2.62	Yes	No	0	8	5
388	V:V:V164	V:V:V20	4.81	No	No	0	8	5
389	V:V:L42	V:V:Y21	2.34	No	Yes	4	4	8
390	V:V:L104	V:V:Y21	4.69	No	Yes	0	9	8
391	V:V:L108	V:V:Y21	9.38	Yes	Yes	4	7	8
392	V:V:G39	V:V:L22	1.71	No	No	0	8	8
393	V:V:G23	V:V:L100	5.13	No	No	0	5	5
394	V:V:E35	V:V:K24	5.4	Yes	No	0	6	7
395	V:V:L166	V:V:R25	4.86	No	Yes	3	8	9
396	V:V:L293	V:V:R25	19.44	No	Yes	0	6	9
397	V:V:D26	V:V:E169	10.39	No	Yes	0	8	9
398	V:V:E35	V:V:F27	2.33	Yes	No	1	6	7
399	V:V:F27	V:V:V37	11.8	No	Yes	1	7	7
400	V:V:F27	V:V:I168	6.28	No	No	1	7	8
401	V:V:H30	V:V:V28	6.92	No	No	1	5	6
402	V:V:E35	V:V:V28	9.98	Yes	No	1	6	6
403	V:V:V28	V:V:Y173	7.57	No	Yes	1	6	4
404	V:V:D29	V:V:V34	4.38	Yes	No	1	8	6
405	V:V:C125	V:V:D29	4.67	No	Yes	1	5	8
406	V:V:D29	V:V:K170	13.83	Yes	Yes	1	8	9
407	V:V:D29	V:V:Q172	15.66	Yes	Yes	1	8	9
408	V:V:D32	V:V:H30	2.52	No	No	0	4	5
409	V:V:E35	V:V:H30	4.92	Yes	No	1	6	5
410	V:V:I31	V:V:R307	2.51	No	Yes	0	4	3
411	V:V:D32	V:V:L33	6.79	No	No	0	4	2
412	V:V:I119	V:V:V34	7.68	Yes	No	1	5	6
413	V:V:K170	V:V:V34	6.07	Yes	No	1	9	6
414	V:V:P36	V:V:T116	1.75	No	No	0	4	3
415	V:V:E118	V:V:P36	3.14	No	No	0	4	4
416	V:V:L57	V:V:V37	2.98	Yes	Yes	1	6	7
417	V:V:F117	V:V:V37	5.24	Yes	Yes	1	7	7
418	V:V:I119	V:V:V37	3.07	Yes	Yes	1	5	7
419	V:V:I168	V:V:V37	3.07	No	Yes	1	8	7
420	V:V:D38	V:V:T98	8.67	No	No	7	7	7
421	V:V:D38	V:V:L100	2.71	No	No	0	7	5
422	V:V:D38	V:V:Q101	3.92	No	Yes	7	7	9
423	V:V:G39	V:V:Q101	1.64	No	Yes	0	8	9
424	V:V:F115	V:V:G39	6.02	Yes	No	0	8	8
425	V:V:Q101	V:V:V40	2.87	Yes	Yes	7	9	7
426	V:V:L104	V:V:V40	5.96	No	Yes	0	9	7
427	V:V:A112	V:V:V40	1.7	No	Yes	0	8	7
428	V:V:P114	V:V:V40	1.77	Yes	Yes	7	7	7
429	V:V:S86	V:V:V41	3.23	No	No	0	5	4
430	V:V:L108	V:V:L42	6.92	Yes	No	4	7	4
431	V:V:V43	V:V:V53	4.81	No	No	3	5	7
432	V:V:F87	V:V:V43	3.93	Yes	No	3	5	5
433	V:V:V43	V:V:Y113	2.52	No	No	3	5	3
434	V:V:D44	V:V:E46	5.2	No	No	0	7	4
435	V:V:D44	V:V:Y47	5.75	No	Yes	3	7	5
436	V:V:E46	V:V:P45	3.14	No	No	0	4	3
437	V:V:H111	V:V:P45	15.25	No	No	0	6	3
438	V:V:L48	V:V:Y47	3.52	Yes	Yes	3	4	5
439	V:V:R51	V:V:Y47	12.35	No	Yes	3	7	5
440	V:V:R161	V:V:Y47	2.06	Yes	Yes	3	7	5
441	V:V:N162	V:V:Y47	10.47	Yes	Yes	3	8	5
442	V:V:L48	V:V:R51	3.64	Yes	No	3	4	7
443	V:V:F87	V:V:L48	3.65	Yes	Yes	3	5	4
444	V:V:C150	V:V:L48	6.35	No	Yes	0	5	4
445	V:V:R52	V:V:Y54	14.4	No	Yes	3	7	4
446	V:V:Q85	V:V:R52	8.18	Yes	No	3	9	7
447	V:V:P88	V:V:R52	4.32	Yes	No	3	9	7
448	V:V:F87	V:V:V53	3.93	Yes	No	3	5	7
449	V:V:C150	V:V:V53	3.42	No	No	0	5	7
450	V:V:Q85	V:V:Y54	4.51	Yes	Yes	3	9	4
451	V:V:F149	V:V:Y54	6.19	Yes	Yes	3	5	4
452	V:V:L154	V:V:Y54	11.72	No	Yes	0	2	4
453	V:V:S86	V:V:V55	4.85	No	Yes	1	5	6
454	V:V:F115	V:V:V55	15.73	Yes	Yes	1	8	6
455	V:V:F117	V:V:V55	5.24	Yes	Yes	1	7	6
456	V:V:A148	V:V:V55	5.09	No	Yes	0	4	6
457	V:V:T56	V:V:T58	3.14	No	No	0	6	5
458	V:V:K147	V:V:T56	7.51	Yes	No	3	5	6
459	V:V:F149	V:V:T56	5.19	Yes	No	3	5	6
460	V:V:F117	V:V:L57	12.18	Yes	Yes	1	7	6
461	V:V:I119	V:V:L57	2.85	Yes	Yes	1	5	6
462	V:V:L57	V:V:V146	2.98	Yes	No	0	6	5
463	V:V:T58	V:V:V81	6.35	No	No	0	5	4
464	V:V:C59	V:V:L79	6.35	Yes	Yes	1	6	6
465	V:V:C59	V:V:P124	1.88	Yes	Yes	1	6	8
466	V:V:C59	V:V:V142	1.71	Yes	Yes	1	6	9
467	V:V:C59	V:V:Y144	13.44	Yes	Yes	1	6	7
468	V:V:A60	V:V:R76	4.15	No	Yes	0	8	6
469	V:V:A60	V:V:D143	3.09	No	No	0	8	6
470	V:V:F61	V:V:Y63	7.22	Yes	Yes	1	9	8
471	V:V:F61	V:V:L79	6.09	Yes	Yes	1	9	6
472	V:V:F61	V:V:V142	5.24	Yes	Yes	1	9	9
473	V:V:F61	V:V:I241	3.77	Yes	Yes	1	9	7
474	V:V:F61	V:V:L243	2.44	Yes	No	1	9	7
475	V:V:F61	V:V:G316	3.01	Yes	Yes	1	9	8
476	V:V:F61	V:V:I317	2.51	Yes	Yes	1	9	8
477	V:V:R62	V:V:R76	3.2	No	Yes	0	8	6
478	V:V:C140	V:V:R62	4.18	No	No	0	6	8
479	V:V:D143	V:V:R62	2.38	No	No	0	6	8
480	V:V:F75	V:V:Y63	8.25	No	Yes	0	8	8
481	V:V:K77	V:V:Y63	10.75	No	Yes	0	8	8
482	V:V:L243	V:V:Y63	15.24	No	Yes	1	7	8
483	V:V:G64	V:V:R65	3	No	No	0	9	7
484	V:V:C140	V:V:G64	1.96	No	No	0	6	9
485	V:V:D67	V:V:R65	7.15	No	No	0	8	7
486	V:V:R65	V:V:T136	2.59	No	Yes	0	7	2
487	V:V:D67	V:V:E66	12.99	No	No	0	8	8
488	V:V:E66	V:V:T136	11.29	No	Yes	0	8	2
489	V:V:E66	V:V:K138	6.75	No	No	0	8	7
490	V:V:G72	V:V:L68	6.84	No	No	6	9	7
491	V:V:L71	V:V:V70	2.98	Yes	Yes	0	8	7
492	V:V:F75	V:V:L73	7.31	No	No	0	8	6
493	V:V:D78	V:V:R76	10.72	No	Yes	0	7	6
494	V:V:K77	V:V:L79	2.82	No	Yes	0	8	6
495	V:V:D78	V:V:V81	4.38	No	No	0	7	4
496	V:V:L79	V:V:P124	3.28	Yes	Yes	1	6	8
497	V:V:L315	V:V:L79	5.54	No	Yes	1	5	6
498	V:V:G316	V:V:L79	1.71	Yes	Yes	1	8	6
499	V:V:A82	V:V:F80	4.16	No	No	0	4	4
500	V:V:F80	V:V:P120	10.11	No	Yes	1	4	6
501	V:V:F80	V:V:L123	3.65	No	Yes	1	4	6
502	V:V:A82	V:V:F117	2.77	No	Yes	0	4	7
503	V:V:L154	V:V:N83	4.12	No	No	0	2	4
504	V:V:F117	V:V:V84	3.93	Yes	No	0	7	3
505	V:V:P88	V:V:Q85	6.32	Yes	Yes	3	9	9
506	V:V:A90	V:V:Q85	4.55	Yes	Yes	3	1	9
507	V:V:F115	V:V:S86	3.96	Yes	No	1	8	5
508	V:V:F87	V:V:P88	2.89	Yes	Yes	3	5	9
509	V:V:F87	V:V:Y113	14.44	Yes	No	3	5	3
510	V:V:P88	V:V:P89	1.95	Yes	No	0	9	3
511	V:V:P89	V:V:Y113	5.56	No	No	0	3	3
512	V:V:A90	V:V:P91	1.87	Yes	No	3	1	1
513	V:V:A90	V:V:E92	3.02	Yes	No	3	1	2
514	V:V:A90	V:V:D93	3.09	Yes	No	0	1	1
515	V:V:E92	V:V:P91	6.29	No	No	3	2	1
516	V:V:K95	V:V:P96	3.35	No	No	0	1	1
517	V:V:K95	V:V:T116	6.01	No	No	0	1	3
518	V:V:L97	V:V:Q101	5.32	No	Yes	7	3	9
519	V:V:E102	V:V:L97	6.63	No	No	0	6	3
520	V:V:L97	V:V:P114	3.28	No	Yes	7	3	7
521	V:V:Q101	V:V:T98	4.25	Yes	No	7	9	7
522	V:V:E102	V:V:R99	4.65	No	No	0	6	4
523	V:V:R103	V:V:R99	6.4	Yes	No	0	5	4
524	V:V:P114	V:V:Q101	6.32	Yes	Yes	7	7	9
525	V:V:I105	V:V:P114	5.08	No	Yes	0	3	7
526	V:V:K107	V:V:L108	5.64	Yes	Yes	4	9	7
527	V:V:G109	V:V:L108	1.71	No	Yes	0	9	7
528	V:V:A112	V:V:L108	3.15	No	Yes	0	8	7
529	V:V:E110	V:V:G109	1.64	No	No	0	2	9
530	V:V:E110	V:V:H111	16	No	No	0	2	6
531	V:V:F115	V:V:F117	5.36	Yes	Yes	1	8	7
532	V:V:F115	V:V:V146	2.62	Yes	No	0	8	5
533	V:V:I119	V:V:P120	3.39	Yes	Yes	1	5	6
534	V:V:P120	V:V:P121	1.95	Yes	No	0	6	3
535	V:V:L123	V:V:P120	4.93	Yes	Yes	1	6	6
536	V:V:A310	V:V:N122	3.13	No	No	0	3	5
537	V:V:I314	V:V:N122	11.33	No	No	0	4	5
538	V:V:L123	V:V:P124	4.93	Yes	Yes	1	6	8
539	V:V:L123	V:V:Y144	2.34	Yes	Yes	1	6	7
540	V:V:K170	V:V:L123	2.82	Yes	Yes	1	9	6
541	V:V:P124	V:V:V142	3.53	Yes	Yes	1	8	9
542	V:V:P124	V:V:Y144	2.78	Yes	Yes	1	8	7
543	V:V:I314	V:V:P124	1.69	No	Yes	0	4	8
544	V:V:G316	V:V:P124	4.06	Yes	Yes	1	8	8
545	V:V:C125	V:V:Q172	6.1	No	Yes	1	5	9
546	V:V:S126	V:V:Y144	2.54	No	Yes	0	9	7
547	V:V:A288	V:V:V127	1.7	Yes	No	1	9	8
548	V:V:A301	V:V:V127	1.7	No	No	1	9	8
549	V:V:I317	V:V:V127	7.68	Yes	No	1	8	8
550	V:V:L289	V:V:T128	4.42	Yes	No	0	7	6
551	V:V:G291	V:V:T128	5.46	No	No	0	8	6
552	V:V:G286	V:V:L129	1.71	No	No	0	7	7
553	V:V:I317	V:V:L129	4.28	Yes	No	0	8	7
554	V:V:P131	V:V:Q130	3.16	No	Yes	0	5	8
555	V:V:G132	V:V:Q130	1.64	No	Yes	0	5	8
556	V:V:Q130	V:V:R282	2.34	Yes	No	0	8	5
557	V:V:L287	V:V:Q130	7.99	Yes	Yes	0	6	8
558	V:V:L289	V:V:Q130	3.99	Yes	Yes	0	7	8
559	V:V:G132	V:V:P133	4.06	No	No	0	5	3
560	V:V:P133	V:V:R285	7.21	No	Yes	0	3	5
561	V:V:D135	V:V:T136	8.67	No	Yes	0	6	2
562	V:V:D135	V:V:R285	2.38	No	Yes	0	6	5
563	V:V:G137	V:V:T136	1.82	No	Yes	0	5	2
564	V:V:G141	V:V:I317	1.76	No	Yes	0	7	8
565	V:V:G316	V:V:V142	1.84	Yes	Yes	1	8	9
566	V:V:I317	V:V:V142	3.07	Yes	Yes	1	8	9
567	V:V:I168	V:V:Y144	2.42	No	Yes	1	8	7
568	V:V:K170	V:V:Y144	11.94	Yes	Yes	1	9	7
569	V:V:E145	V:V:R165	10.47	No	No	0	7	5
570	V:V:E145	V:V:V167	4.28	No	No	0	7	5
571	V:V:F149	V:V:K147	9.93	Yes	Yes	3	5	5
572	V:V:I158	V:V:K147	4.36	No	Yes	3	3	5
573	V:V:A148	V:V:V164	1.7	No	No	0	4	8
574	V:V:F149	V:V:I158	13.82	Yes	No	3	5	3
575	V:V:A151	V:V:E156	3.02	No	No	0	5	6
576	V:V:E152	V:V:E156	3.81	No	No	0	4	6
577	V:V:E155	V:V:N153	5.26	No	No	0	5	4
578	V:V:E156	V:V:N153	7.89	No	No	0	6	4
579	V:V:H159	V:V:K157	3.93	No	No	0	5	5
580	V:V:H159	V:V:R161	5.64	No	Yes	3	5	7
581	V:V:H159	V:V:N162	5.1	No	Yes	3	5	8
582	V:V:K160	V:V:R165	6.19	No	No	0	6	5
583	V:V:N162	V:V:R161	4.82	Yes	Yes	3	8	7
584	V:V:L293	V:V:V167	2.98	No	No	0	6	5
585	V:V:E169	V:V:V171	2.85	Yes	No	0	9	6
586	V:V:E169	V:V:K292	5.4	Yes	Yes	0	9	5
587	V:V:E169	V:V:L293	10.6	Yes	No	0	9	6
588	V:V:V171	V:V:Y173	3.79	No	Yes	0	6	4
589	V:V:L305	V:V:Q172	6.65	No	Yes	1	5	9
590	V:V:M352	V:V:Q172	2.72	Yes	Yes	1	7	9
591	V:V:H353	V:V:Y173	2.18	Yes	Yes	1	8	4
592	V:V:K355	V:V:Y173	8.36	No	Yes	1	6	4
593	V:V:P356	V:V:Y173	13.91	No	Yes	1	7	4
594	V:V:A174	V:V:P175	1.87	No	Yes	1	8	8
595	V:V:A174	V:V:Y209	5.34	No	No	0	8	5
596	V:V:A174	V:V:M352	3.22	No	Yes	1	8	7
597	V:V:I207	V:V:P175	5.08	No	Yes	0	4	8
598	V:V:L305	V:V:P175	4.93	No	Yes	1	5	8
599	V:V:M352	V:V:P175	1.68	Yes	Yes	1	7	8
600	V:V:E176	V:V:R177	2.33	No	No	0	3	1
601	V:V:G179	V:V:P180	4.06	No	No	1	2	4
602	V:V:E206	V:V:G179	3.27	Yes	No	1	7	2
603	V:V:E206	V:V:P180	4.72	Yes	No	1	7	4
604	V:V:P182	V:V:Q181	3.16	Yes	No	0	8	7
605	V:V:Q181	V:V:S202	2.89	No	No	0	7	6
606	V:V:L203	V:V:P182	11.49	Yes	Yes	1	9	8
607	V:V:E206	V:V:P182	4.72	Yes	Yes	1	7	8
608	V:V:L347	V:V:P182	1.64	Yes	Yes	1	6	8
609	V:V:E200	V:V:T183	2.82	No	No	0	7	4
610	V:V:S202	V:V:T183	3.2	No	No	0	6	4
611	V:V:A184	V:V:V345	5.09	No	Yes	0	5	6
612	V:V:A184	V:V:L347	3.15	No	Yes	0	5	6
613	V:V:E185	V:V:T187	2.82	No	No	0	6	4
614	V:V:E185	V:V:H198	11.08	No	No	8	6	5
615	V:V:E185	V:V:E200	5.07	No	No	8	6	7
616	V:V:T186	V:V:V345	4.76	No	Yes	0	6	6
617	V:V:P196	V:V:T187	3.5	No	No	0	5	4
618	V:V:F190	V:V:R188	4.28	Yes	No	10	9	7
619	V:V:R188	V:V:S341	3.95	No	No	10	7	8
620	V:V:R188	V:V:V343	3.92	No	No	0	7	6
621	V:V:M192	V:V:Q189	5.44	No	No	0	7	5
622	V:V:P196	V:V:Q189	11.05	No	No	0	5	5
623	V:V:F190	V:V:T224	6.49	Yes	No	0	9	8
624	V:V:F190	V:V:K226	18.61	Yes	No	10	9	8
625	V:V:F190	V:V:V329	2.62	Yes	No	10	9	5
626	V:V:F190	V:V:S341	2.64	Yes	No	10	9	8
627	V:V:L191	V:V:S193	4.5	No	No	0	5	8
628	V:V:S193	V:V:T224	3.2	No	No	0	8	8
629	V:V:N225	V:V:S193	2.98	No	No	0	5	8
630	V:V:D194	V:V:K195	2.77	No	No	0	6	7
631	V:V:K195	V:V:P196	5.02	No	No	0	7	5
632	V:V:K195	V:V:N223	4.2	No	No	0	7	6
633	V:V:L197	V:V:N222	4.12	No	No	0	7	9
634	V:V:L197	V:V:V343	4.47	No	No	0	7	6
635	V:V:E200	V:V:H198	3.69	No	No	8	7	5
636	V:V:H198	V:V:T221	4.11	No	No	8	5	5
637	V:V:L199	V:V:L327	4.15	No	Yes	0	7	7
638	V:V:L199	V:V:V345	7.45	No	Yes	0	7	6
639	V:V:A201	V:V:V325	3.39	No	Yes	1	6	7
640	V:V:A201	V:V:V345	1.7	No	Yes	1	6	6
641	V:V:A201	V:V:L347	4.73	No	Yes	1	6	6
642	V:V:N217	V:V:S202	2.98	No	No	0	6	6
643	V:V:L203	V:V:Y208	7.03	Yes	Yes	1	9	7
644	V:V:L203	V:V:V216	4.47	Yes	No	1	9	7
645	V:V:L203	V:V:V323	5.96	Yes	Yes	1	9	5
646	V:V:L203	V:V:L347	6.92	Yes	Yes	1	9	6
647	V:V:F349	V:V:L203	3.65	Yes	Yes	1	8	9
648	V:V:D204	V:V:K205	11.06	No	No	1	6	8
649	V:V:D204	V:V:Y208	12.64	No	Yes	1	6	7
650	V:V:D204	V:V:S215	2.94	No	No	0	6	3
651	V:V:K205	V:V:Y208	13.14	No	Yes	1	8	7
652	V:V:E206	V:V:T350	4.23	Yes	Yes	0	7	5
653	V:V:I207	V:V:T350	4.56	No	Yes	0	4	5
654	V:V:E212	V:V:Y208	2.24	No	Yes	0	7	7
655	V:V:I214	V:V:Y208	15.71	No	Yes	1	7	7
656	V:V:F349	V:V:Y208	8.25	Yes	Yes	1	8	7
657	V:V:E212	V:V:Y209	12.35	No	No	0	7	5
658	V:V:P354	V:V:Y209	22.25	No	No	0	7	5
659	V:V:H210	V:V:N299	12.75	Yes	No	1	9	8
660	V:V:H210	V:V:S302	6.97	Yes	No	0	9	9
661	V:V:H210	V:V:L351	9	Yes	No	1	9	8
662	V:V:H210	V:V:H353	17.91	Yes	Yes	1	9	8
663	V:V:G211	V:V:T275	1.82	No	No	0	8	4
664	V:V:P213	V:V:T273	1.75	No	No	0	4	3
665	V:V:P213	V:V:T275	1.75	No	No	0	4	4
666	V:V:I214	V:V:P276	5.08	No	Yes	1	7	9
667	V:V:F349	V:V:I214	5.02	Yes	No	1	8	7
668	V:V:I233	V:V:V216	4.61	Yes	No	1	5	7
669	V:V:V216	V:V:V323	3.21	No	Yes	1	7	5
670	V:V:N217	V:V:V271	4.43	No	No	0	6	5
671	V:V:V218	V:V:Y272	5.05	No	Yes	0	6	4
672	V:V:V218	V:V:V325	4.81	No	Yes	0	6	7
673	V:V:H219	V:V:T221	2.74	No	No	8	4	5
674	V:V:H219	V:V:T267	4.11	No	No	8	4	5
675	V:V:C269	V:V:H219	8.85	No	No	0	5	4
676	V:V:L327	V:V:V220	7.45	Yes	No	0	7	7
677	V:V:T221	V:V:T267	3.14	No	No	8	5	5
678	V:V:N222	V:V:T224	4.39	No	No	0	9	8
679	V:V:N222	V:V:V262	2.96	No	Yes	0	9	7
680	V:V:K226	V:V:V329	4.55	No	No	10	8	5
681	V:V:K226	V:V:R331	7.43	No	No	0	8	4
682	V:V:P264	V:V:T227	6.99	No	No	0	5	5
683	V:V:V228	V:V:V262	8.02	No	Yes	0	8	7
684	V:V:L327	V:V:V228	5.96	Yes	No	0	7	8
685	V:V:V228	V:V:V329	3.21	No	No	0	8	5
686	V:V:K229	V:V:V328	3.04	No	No	18	8	3
687	V:V:K229	V:V:S330	4.59	No	No	0	8	6
688	V:V:K229	V:V:S340	3.06	No	No	18	8	4
689	V:V:K230	V:V:K232	4.31	No	No	0	7	6
690	V:V:D259	V:V:K230	2.77	No	No	0	3	7
691	V:V:K230	V:V:V328	4.55	No	No	0	7	3
692	V:V:I231	V:V:I233	2.94	Yes	Yes	1	7	5
693	V:V:F268	V:V:I231	2.51	Yes	Yes	1	4	7
694	V:V:I231	V:V:Y272	3.63	Yes	Yes	1	7	4
695	V:V:I231	V:V:L327	7.14	Yes	Yes	0	7	7
696	V:V:E257	V:V:K232	9.45	No	No	0	7	6
697	V:V:K232	V:V:K326	8.62	No	No	0	6	7
698	V:V:I233	V:V:Y272	12.09	Yes	Yes	1	5	4
699	V:V:I233	V:V:L274	7.14	Yes	No	0	5	5
700	V:V:I233	V:V:V325	4.61	Yes	Yes	1	5	7
701	V:V:R236	V:V:S234	2.64	Yes	No	5	5	5
702	V:V:K324	V:V:S234	3.06	Yes	No	5	8	5
703	V:V:A254	V:V:V235	3.39	No	No	0	6	6
704	V:V:L274	V:V:V235	2.98	No	No	0	5	6
705	V:V:F349	V:V:V235	2.62	Yes	No	0	8	6
706	V:V:R236	V:V:Y238	11.32	Yes	Yes	5	5	3
707	V:V:K250	V:V:R236	11.14	No	Yes	5	6	5
708	V:V:K324	V:V:R236	8.66	Yes	Yes	5	8	5
709	V:V:L287	V:V:Q237	9.32	Yes	Yes	0	6	9
710	V:V:A288	V:V:Q237	4.55	Yes	Yes	1	9	9
711	V:V:Q237	V:V:V319	4.3	Yes	Yes	1	9	8
712	V:V:Q237	V:V:Y321	15.78	Yes	Yes	1	9	9
713	V:V:Q248	V:V:Y238	4.51	No	Yes	5	5	3
714	V:V:K250	V:V:Y238	4.78	No	Yes	5	6	3
715	V:V:S320	V:V:Y238	3.82	No	Yes	0	8	3
716	V:V:K322	V:V:Y238	13.14	No	Yes	5	5	3
717	V:V:E346	V:V:Y238	4.49	No	Yes	5	8	3
718	V:V:D240	V:V:Q248	10.44	No	No	0	6	5
719	V:V:D240	V:V:I318	7	No	No	0	6	5
720	V:V:I241	V:V:I317	2.94	Yes	Yes	1	7	8
721	V:V:C242	V:V:T246	6.76	No	No	0	5	6
722	V:V:R312	V:V:T246	5.17	No	No	0	5	6
723	V:V:K250	V:V:Q248	2.71	No	No	5	6	5
724	V:V:C251	V:V:Y249	2.69	Yes	No	0	6	6
725	V:V:G286	V:V:Y249	4.35	No	No	0	7	6
726	V:V:C251	V:V:P252	3.77	Yes	No	0	6	3
727	V:V:C251	V:V:K284	4.85	Yes	No	0	6	7
728	V:V:C251	V:V:L287	3.17	Yes	Yes	0	6	6
729	V:V:P276	V:V:V253	3.53	Yes	No	1	9	8
730	V:V:N281	V:V:V253	4.43	No	No	0	8	8
731	V:V:L300	V:V:V253	4.47	Yes	No	1	9	8
732	V:V:E257	V:V:M255	4.06	No	No	0	7	3
733	V:V:E256	V:V:Y272	5.61	No	Yes	0	4	4
734	V:V:E256	V:V:L274	6.63	No	No	0	4	5
735	V:V:A258	V:V:D260	3.09	No	Yes	1	5	5
736	V:V:A258	V:V:Y272	4	No	Yes	1	5	4
737	V:V:D260	V:V:F268	8.36	Yes	Yes	1	5	4
738	V:V:D260	V:V:K270	5.53	Yes	No	1	5	7
739	V:V:D260	V:V:Y272	5.75	Yes	Yes	1	5	4
740	V:V:F268	V:V:V262	6.55	Yes	Yes	0	4	7
741	V:V:A263	V:V:P264	1.87	No	No	0	3	5
742	V:V:A263	V:V:S266	3.42	No	No	0	3	5
743	V:V:F268	V:V:K270	8.69	Yes	No	1	4	7
744	V:V:F268	V:V:Y272	3.09	Yes	Yes	1	4	4
745	V:V:K270	V:V:Y272	19.11	No	Yes	1	7	4
746	V:V:P276	V:V:T275	3.5	Yes	No	0	9	4
747	V:V:L300	V:V:P276	3.28	Yes	Yes	1	9	9
748	V:V:A279	V:V:F277	2.77	No	No	0	4	3
749	V:V:F277	V:V:N280	12.08	No	No	0	3	4
750	V:V:L278	V:V:L289	2.77	No	Yes	0	7	7
751	V:V:N280	V:V:N281	9.54	No	No	0	4	8
752	V:V:K284	V:V:N281	12.59	No	No	0	7	8
753	V:V:L287	V:V:L300	2.77	Yes	Yes	0	6	9
754	V:V:A288	V:V:A301	1.79	Yes	No	1	9	9
755	V:V:A288	V:V:V319	1.7	Yes	Yes	1	9	8
756	V:V:L289	V:V:T298	5.9	Yes	No	0	7	8
757	V:V:D290	V:V:K292	6.91	No	Yes	0	9	5
758	V:V:D290	V:V:N299	6.73	No	No	1	9	8
759	V:V:D290	V:V:H353	2.52	No	Yes	1	9	8
760	V:V:E296	V:V:K292	2.7	No	Yes	0	7	5
761	V:V:K292	V:V:T298	6.01	Yes	No	0	5	8
762	V:V:H353	V:V:N299	6.38	Yes	No	1	8	8
763	V:V:L300	V:V:Y321	3.52	Yes	Yes	1	9	9
764	V:V:A301	V:V:V319	5.09	No	Yes	1	9	8
765	V:V:S303	V:V:Y321	6.36	No	Yes	0	8	9
766	V:V:S303	V:V:T350	3.2	No	Yes	0	8	5
767	V:V:L306	V:V:T304	4.42	No	No	19	2	9
768	V:V:I318	V:V:T304	7.6	No	No	19	5	9
769	V:V:L305	V:V:M352	7.07	No	Yes	1	5	7
770	V:V:I318	V:V:L306	4.28	No	No	19	5	2
771	V:V:E308	V:V:R307	2.33	No	Yes	0	3	3
772	V:V:G309	V:V:R307	3	No	Yes	0	3	3
773	V:V:A310	V:V:R307	2.77	No	Yes	0	3	3
774	V:V:G316	V:V:L315	1.71	Yes	No	1	8	5
775	V:V:V319	V:V:Y321	5.05	Yes	Yes	1	8	9
776	V:V:F349	V:V:Y321	8.25	Yes	Yes	1	8	9
777	V:V:L351	V:V:Y321	8.21	No	Yes	1	8	9
778	V:V:E346	V:V:K322	8.1	No	No	5	8	5
779	V:V:K322	V:V:P348	5.02	No	No	0	5	9
780	V:V:L347	V:V:V323	4.47	Yes	Yes	1	6	5
781	V:V:F349	V:V:V323	2.62	Yes	Yes	1	8	5
782	V:V:A344	V:V:K324	4.82	No	Yes	0	3	8
783	V:V:E346	V:V:K324	6.75	No	Yes	5	8	8
784	V:V:V325	V:V:V345	3.21	Yes	Yes	1	7	6
785	V:V:D342	V:V:K326	4.15	No	No	0	7	7
786	V:V:A344	V:V:K326	3.21	No	No	0	3	7
787	V:V:S340	V:V:V328	3.23	No	No	18	4	3
788	V:V:A339	V:V:R331	4.15	No	No	0	3	4
789	V:V:G332	V:V:G333	2.11	No	No	0	4	7
790	V:V:D337	V:V:G332	1.68	No	No	0	3	4
791	V:V:L334	V:V:L335	4.15	No	No	0	5	6
792	V:V:D337	V:V:G336	1.68	No	No	0	3	3
793	V:V:A339	V:V:D337	4.63	No	No	0	3	3
794	V:V:L347	V:V:P348	1.64	Yes	No	0	6	9
795	V:V:F349	V:V:L351	2.44	Yes	No	1	8	8
796	V:V:M352	V:V:T350	3.01	Yes	Yes	0	7	5
797	V:V:H353	V:V:P354	3.05	Yes	No	0	8	7
798	V:V:K355	V:V:P356	3.35	No	No	1	6	7
799	R:R:A339	R:R:I109	1.62	No	No	0	6	8
800	R:R:S147	R:R:V204	1.62	No	Yes	0	6	5
801	V:V:A151	V:V:I158	1.62	No	No	0	5	3
802	V:V:A239	V:V:I241	1.62	No	Yes	1	6	7
803	V:V:A239	V:V:I317	1.62	No	Yes	1	6	8
804	V:V:S266	V:V:V262	1.62	No	Yes	0	5	7
805	R:R:A70	R:R:M67	1.61	No	No	0	4	2
806	R:R:V82	R:R:V83	1.6	No	No	0	6	5
807	R:R:S121	R:R:T122	1.6	No	Yes	0	5	6
808	R:R:V286	R:R:V287	1.6	No	No	0	6	8
809	R:R:T69	R:R:V318	1.59	No	No	0	4	1
810	R:R:T251	R:R:V252	1.59	No	No	0	5	4
811	R:R:T317	R:R:V318	1.59	No	No	0	4	1
812	V:V:C242	V:V:L315	1.59	No	No	0	5	5
813	V:V:E35	V:V:P36	1.57	Yes	No	0	6	4
814	V:V:E358	V:V:P356	1.57	No	No	0	1	7
815	R:R:A119	R:R:N152	1.56	No	Yes	0	7	8
816	R:R:I292	R:R:V247	1.54	No	No	0	6	6
817	R:R:I258	R:R:V284	1.54	No	No	0	5	8
818	R:R:I292	R:R:V288	1.54	No	No	0	6	8
819	R:R:I292	R:R:V293	1.54	No	No	0	6	6
820	R:R:M74	R:R:S78	1.53	Yes	No	0	5	4
821	R:R:H173	R:R:P174	1.53	No	No	0	6	8
822	V:V:K147	V:V:S163	1.53	Yes	No	0	5	8
823	R:R:I73	R:R:T72	1.52	Yes	No	0	6	4
824	R:R:M101	R:R:V96	1.52	No	No	0	7	3
825	R:R:L256	R:R:V252	1.49	No	No	0	5	4
826	R:R:L337	R:R:V290	1.49	No	Yes	0	8	7
827	V:V:L68	V:V:V70	1.49	No	Yes	6	7	7
828	R:R:I140	R:R:I144	1.47	No	No	0	1	5
829	R:R:I144	R:R:I148	1.47	No	No	0	5	5
830	R:R:L248	R:R:T251	1.47	No	No	0	3	5
831	R:R:L277	R:R:T281	1.47	No	No	0	6	6
832	R:R:I300	R:R:I304	1.47	No	No	0	6	5
833	R:R:I304	R:R:I310	1.47	No	Yes	0	5	4
834	V:V:D259	V:V:T261	1.45	No	No	0	3	6
835	V:V:P178	V:V:R177	1.44	No	No	0	3	1
836	R:R:I303	R:R:L307	1.43	No	No	0	5	5
837	R:R:I308	R:R:L307	1.43	No	No	0	2	5
838	R:R:I188	R:R:N185	1.42	No	No	0	3	4
839	R:R:Q316	R:R:T313	1.42	Yes	No	0	3	3
840	V:V:I314	V:V:N311	1.42	No	No	0	4	4
841	R:R:G327	R:R:W295	1.41	No	Yes	0	7	8
842	R:R:K235	R:R:N232	1.4	Yes	No	0	4	2
843	R:R:C237	R:R:F241	1.4	No	No	0	5	4
844	R:R:D179	R:R:K176	1.38	No	No	0	5	4
845	R:R:D179	R:R:L178	1.36	No	No	0	5	4
846	V:V:E50	V:V:K49	1.35	No	No	0	3	5
847	R:R:F315	R:R:V318	1.31	No	No	0	2	1
848	V:V:R76	V:V:T74	1.29	Yes	No	0	6	5
849	R:R:E312	R:R:Q316	1.27	No	Yes	0	2	3
850	R:R:F180	R:R:K176	1.24	No	No	0	3	4
851	R:R:K346	R:R:R350	1.24	No	No	0	8	5
852	R:R:F322	R:R:L76	1.22	No	No	0	4	5
853	V:V:F244	V:V:N245	1.21	No	No	0	7	7
854	R:R:D274	R:R:R275	1.19	No	No	0	1	4
855	V:V:E283	V:V:R282	1.16	No	No	0	4	5
856	V:V:E313	V:V:R312	1.16	No	No	0	8	5
857	R:R:L233	R:R:W230	1.14	No	Yes	0	3	1
858	R:R:R275	R:R:R278	1.07	No	No	0	4	5
859	R:R:R279	R:R:R282	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	5.854	5	2	0
2	L:L:P2	6.156	5	2	0
3	L:L:W3	7.69143	7	2	0
4	L:L:F4	8.31857	7	2	0
5	R:R:I73	7.0775	4	2	6
6	R:R:M74	4.765	4	0	5
7	R:R:Y77	5.70714	7	2	7
8	R:R:C81	4.1675	4	2	6
9	R:R:N88	3.83	4	2	9
10	R:R:Y108	6.57833	6	2	7
11	R:R:L112	4.852	5	2	9
12	R:R:D116	6.45	6	2	9
13	R:R:T122	2.99	5	2	6
14	R:R:L123	6.1	4	2	7
15	R:R:F125	7.83	4	2	6
16	R:R:Q126	6.795	4	2	6
17	R:R:Y130	9.44	4	2	5
18	R:R:T134	2.4525	4	0	5
19	R:R:W135	7.51889	9	2	8
20	R:R:F137	9.906	5	2	6
21	R:R:V145	5.21	4	2	5
22	R:R:I146	3.812	5	2	4
23	R:R:Y151	6.9275	4	2	5
24	R:R:N152	6.1575	4	0	8
25	R:R:M153	4.065	4	2	7
26	R:R:F154	6.438	5	2	6
27	R:R:T155	6.925	4	2	7
28	R:R:I157	3.502	5	2	7
29	R:R:L160	4.55	4	2	8
30	R:R:C161	2.1925	4	2	7
31	R:R:M163	4.996	5	2	9
32	R:R:R167	3.38	4	2	9
33	R:R:Y168	5.13667	6	0	8
34	R:R:R181	6.33	4	6	7
35	R:R:W194	8.53167	6	2	9
36	R:R:V204	2.895	4	2	5
37	R:R:C219	7.535	4	2	9
38	R:R:F223	11.74	4	9	6
39	R:R:W230	12.715	4	9	1
40	R:R:K235	3.67	4	2	4
41	R:R:F239	5.646	5	2	6
42	R:R:F243	7.2675	4	2	8
43	R:R:C253	3.805	4	0	8
44	R:R:Y254	4.07857	7	2	9
45	R:R:M257	3.3375	4	2	8
46	R:R:V290	2.6575	4	2	7
47	R:R:F291	4.662	5	2	9
48	R:R:W295	4.72286	7	2	8
49	R:R:I298	3.865	4	2	6
50	R:R:Y301	6.064	5	2	5
51	R:R:V302	4.034	5	2	5
52	R:R:I310	4.506	5	2	4
53	R:R:Q316	4.802	5	2	3
54	R:R:W320	4.76143	7	2	4
55	R:R:H321	10.0417	6	2	4
56	R:R:I324	4.762	5	2	5
57	R:R:Y328	6.21	4	0	7
58	R:R:N330	7.298	5	2	9
59	R:R:N334	6.738	5	2	9
60	R:R:Y338	3.93714	7	2	9
61	R:R:F345	6.13	5	11	8
62	R:R:C348	3.338	5	13	6
63	R:R:E365	4.4675	4	3	3
64	R:R:?366	4.816	5	3	6
65	R:R:?368	7.785	4	3	4
66	R:R:?369	9.89333	6	3	6
67	R:R:?371	12.265	4	4	4
68	R:R:?372	12.8257	7	4	7
69	R:R:?373	13.08	4	4	5
70	R:R:L374	6.686	5	4	5
71	V:V:K11	8.36	4	3	9
72	V:V:S13	5.465	4	3	8
73	V:V:N15	5.995	6	3	9
74	V:V:Y21	5.85667	6	4	8
75	V:V:R25	10.9375	4	3	9
76	V:V:D29	9.635	4	1	8
77	V:V:E35	4.84	5	1	6
78	V:V:V37	5.232	5	1	7
79	V:V:V40	3.075	4	7	7
80	V:V:Y47	6.74714	7	3	5
81	V:V:L48	4.29	4	3	4
82	V:V:Y54	9.205	4	3	4
83	V:V:V55	7.7275	4	1	6
84	V:V:L57	5.2475	4	1	6
85	V:V:C59	5.845	4	1	6
86	V:V:F61	4.32571	7	1	9
87	V:V:Y63	10.365	4	1	8
88	V:V:D69	7.76	4	15	9
89	V:V:V70	2.5225	4	6	7
90	V:V:L71	4.158	5	0	8
91	V:V:R76	4.84	4	0	6
92	V:V:L79	4.29833	6	1	6
93	V:V:Q85	5.89	4	3	9
94	V:V:F87	5.768	5	3	5
95	V:V:P88	3.87	4	3	9
96	V:V:A90	3.1325	4	3	1
97	V:V:Q101	4.05333	6	7	9
98	V:V:R103	8.775	4	4	5
99	V:V:K107	6.0125	4	4	9
100	V:V:L108	5.36	5	4	7
101	V:V:P114	4.1125	4	7	7
102	V:V:F115	6.05167	6	1	8
103	V:V:F117	5.78667	6	1	7
104	V:V:I119	4.2475	4	1	5
105	V:V:P120	5.095	4	1	6
106	V:V:L123	3.734	5	1	6
107	V:V:P124	3.16429	7	1	8
108	V:V:Q130	3.824	5	0	8
109	V:V:T136	6.0925	4	0	2
110	V:V:V142	3.078	5	1	9
111	V:V:Y144	5.91	6	1	7
112	V:V:K147	5.8325	4	3	5
113	V:V:F149	8.7825	4	3	5
114	V:V:R161	3.75167	6	3	7
115	V:V:N162	7.8225	4	3	8
116	V:V:E169	7.31	4	0	9
117	V:V:K170	8.665	4	1	9
118	V:V:Q172	7.7825	4	1	9
119	V:V:Y173	7.162	5	1	4
120	V:V:P175	3.39	4	1	8
121	V:V:P182	5.2525	4	1	8
122	V:V:F190	6.928	5	10	9
123	V:V:L203	6.58667	6	1	9
124	V:V:E206	4.235	4	1	7
125	V:V:Y208	9.835	6	1	7
126	V:V:H210	11.6575	4	1	9
127	V:V:I231	4.055	4	1	7
128	V:V:I233	6.278	5	1	5
129	V:V:R236	8.44	4	5	5
130	V:V:Q237	8.4875	4	1	9
131	V:V:Y238	7.01	6	5	3
132	V:V:I241	4.0025	4	1	7
133	V:V:C251	3.62	4	0	6
134	V:V:D260	5.6825	4	1	5
135	V:V:V262	4.7875	4	0	7
136	V:V:F268	5.84	5	1	4
137	V:V:Y272	7.29125	8	1	4
138	V:V:P276	3.8475	4	1	9
139	V:V:R285	4.6225	4	0	5
140	V:V:L287	5.8125	4	0	6
141	V:V:A288	2.435	4	1	9
142	V:V:L289	4.27	4	0	7
143	V:V:K292	5.255	4	0	5
144	V:V:L300	3.51	4	1	9
145	V:V:R307	2.6525	4	0	3
146	V:V:G316	2.466	5	1	8
147	V:V:I317	3.40857	7	1	8
148	V:V:V319	4.035	4	1	8
149	V:V:Y321	7.86167	6	1	9
150	V:V:V323	4.065	4	1	5
151	V:V:K324	5.8225	4	5	8
152	V:V:V325	4.005	4	1	7
153	V:V:L327	6.175	4	0	7
154	V:V:V345	4.442	5	1	6
155	V:V:L347	3.75833	6	1	6
156	V:V:F349	4.69286	7	1	8
157	V:V:T350	3.75	4	0	5
158	V:V:M352	3.54	5	1	7
159	V:V:H353	6.408	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:Y1	10.952	6.95	Yes	Yes	2	0	0
2	L:L:Y1	R:R:M153	16.5204	4.79	Yes	Yes	2	0	7
3	L:L:?5	L:L:F4	15.6046	12.06	No	Yes	0	0	0
4	L:L:F4	R:R:W320	21.9894	2	Yes	Yes	2	0	4
5	L:L:P2	R:R:W320	14.7324	6.76	Yes	Yes	2	0	4
6	L:L:F4	R:R:I324	10.9629	5.02	Yes	Yes	2	0	5
7	L:L:P2	R:R:I324	17.9105	6.77	Yes	Yes	2	0	5
8	L:L:?5	L:L:W3	14.7375	14.09	No	Yes	0	0	0
9	L:L:F4	R:R:Q126	15.715	9.37	Yes	Yes	2	0	6
10	L:L:W3	R:R:Q126	18.0461	10.95	Yes	Yes	2	0	6
11	L:L:W3	R:R:W135	30.2706	5.62	Yes	Yes	2	0	8
12	R:R:T122	R:R:V145	11.684	3.17	Yes	Yes	2	6	5
13	L:L:P2	R:R:I298	21.9773	6.77	Yes	Yes	2	0	6
14	R:R:I298	R:R:W295	34.1386	2.35	Yes	Yes	2	6	8
15	R:R:T120	R:R:Y328	10.2898	3.75	No	Yes	0	5	7
16	R:R:S331	R:R:T120	11.4691	4.8	No	No	0	9	5
17	R:R:D116	R:R:S331	11.6615	10.31	Yes	No	0	9	9
18	R:R:F291	R:R:W295	19.0417	11.02	Yes	Yes	2	9	8
19	R:R:L112	R:R:S156	10.8052	3	Yes	No	2	9	9
20	R:R:F137	R:R:W135	30.0025	20.04	Yes	Yes	2	6	8
21	R:R:F137	R:R:P136	28.8836	5.78	Yes	No	0	6	3
22	R:R:P136	R:R:T134	28.5774	1.75	No	Yes	0	3	5
23	R:R:S216	R:R:T134	15.8767	3.2	No	Yes	0	1	5
24	R:R:I157	R:R:M153	23.0971	2.92	Yes	Yes	2	7	7
25	R:R:I157	R:R:W295	18.8401	7.05	Yes	Yes	2	7	8
26	R:R:C161	R:R:I157	41.9644	1.64	Yes	Yes	2	7	7
27	R:R:C161	R:R:S164	21.0732	1.72	Yes	No	0	7	9
28	R:R:F291	R:R:I250	20.0511	2.51	Yes	No	0	9	8
29	R:R:I250	R:R:S164	10.0012	3.1	No	No	0	8	9
30	R:R:C161	R:R:I249	21.0729	1.64	Yes	No	0	7	6
31	R:R:C253	R:R:S164	31.0952	3.44	Yes	No	0	8	9
32	R:R:C253	R:R:I249	21.2044	1.64	Yes	No	0	8	6
33	R:R:R167	R:R:Y338	18.078	3.09	Yes	Yes	2	9	9
34	R:R:I250	R:R:Y254	10.1656	2.42	No	Yes	0	8	9
35	R:R:M257	R:R:Y254	28.4084	2.39	Yes	Yes	2	8	9
36	R:R:C253	R:R:Y168	52.3423	6.72	Yes	Yes	0	8	8
37	R:R:M257	R:R:Y168	47.5685	2.39	Yes	Yes	0	8	8
38	R:R:H173	R:R:Y168	99.9822	4.36	No	Yes	0	6	8
39	R:R:H173	R:R:P174	99.9911	1.53	No	No	0	6	8
40	R:R:P174	V:V:L243	100	1.64	No	No	0	8	7
41	V:V:F61	V:V:L243	99.8544	2.44	Yes	No	1	9	7
42	V:V:F61	V:V:I317	44.4698	2.51	Yes	Yes	1	9	8
43	V:V:F61	V:V:L79	21.764	6.09	Yes	Yes	1	9	6
44	V:V:C59	V:V:Y144	18.1573	13.44	Yes	Yes	1	6	7
45	V:V:I168	V:V:Y144	42.8749	2.42	No	Yes	1	8	7
46	V:V:F27	V:V:I168	30.7486	6.28	No	No	1	7	8
47	V:V:E35	V:V:F27	30.7296	2.33	Yes	No	1	6	7
48	V:V:E35	V:V:V28	28.8464	9.98	Yes	No	1	6	6
49	V:V:V28	V:V:Y173	28.7065	7.57	No	Yes	1	6	4
50	V:V:V171	V:V:Y173	29.3368	3.79	No	Yes	0	6	4
51	V:V:E169	V:V:V171	29.1427	2.85	Yes	No	0	9	6
52	V:V:E169	V:V:L293	37.3953	10.6	Yes	No	0	9	6
53	V:V:L293	V:V:R25	23.1485	19.44	No	Yes	0	6	9
54	R:R:?369	V:V:R25	15.525	11.97	Yes	Yes	3	6	9
55	V:V:F61	V:V:V142	21.446	5.24	Yes	Yes	1	9	9
56	V:V:L79	V:V:P124	12.4189	3.28	Yes	Yes	1	6	8
57	V:V:P124	V:V:Y144	27.2597	2.78	Yes	Yes	1	8	7
58	V:V:P124	V:V:V142	12.6211	3.53	Yes	Yes	1	8	9
59	V:V:F61	V:V:G316	12.689	3.01	Yes	Yes	1	9	8
60	V:V:G316	V:V:P124	12.3941	4.06	Yes	Yes	1	8	8
61	V:V:I317	V:V:V127	42.0747	7.68	Yes	No	1	8	8
62	V:V:A288	V:V:V127	30.1104	1.7	Yes	No	1	9	8
63	V:V:A288	V:V:Q237	18.1851	4.55	Yes	Yes	1	9	9
64	R:R:?366	V:V:K11	13.2941	4.8	Yes	Yes	3	6	9
65	V:V:L293	V:V:V167	14.0086	2.98	No	No	0	6	5
66	V:V:E145	V:V:V167	13.7578	4.28	No	No	0	7	5
67	V:V:E145	V:V:R165	13.5101	10.47	No	No	0	7	5
68	R:R:?366	R:R:E365	25.5721	2.25	Yes	Yes	3	6	3
69	R:R:E365	V:V:R161	23.1328	3.49	Yes	Yes	3	3	7
70	V:V:I168	V:V:V37	11.9353	3.07	No	Yes	1	8	7
71	V:V:F117	V:V:V37	11.589	5.24	Yes	Yes	1	7	7
72	V:V:F115	V:V:F117	16.2411	5.36	Yes	Yes	1	8	7
73	V:V:F115	V:V:G39	14.3903	6.02	Yes	No	0	8	8
74	V:V:G39	V:V:Q101	13.7393	1.64	No	Yes	0	8	9
75	V:V:R161	V:V:Y47	14.3242	2.06	Yes	Yes	3	7	5
76	V:V:L48	V:V:Y47	10.3549	3.52	Yes	Yes	3	4	5
77	V:V:A301	V:V:V127	11.9412	1.7	No	No	1	9	8
78	V:V:Q237	V:V:Y321	12.2025	15.78	Yes	Yes	1	9	9
79	V:V:A288	V:V:V319	11.9033	1.7	Yes	Yes	1	9	8
80	V:V:V319	V:V:Y321	23.7533	5.05	Yes	Yes	1	8	9
81	V:V:A301	V:V:V319	11.9186	5.09	No	Yes	1	9	8
82	V:V:F349	V:V:Y321	33.6743	8.25	Yes	Yes	1	8	9
83	V:V:F349	V:V:L203	15.0627	3.65	Yes	Yes	1	8	9
84	V:V:F349	V:V:V323	12.3317	2.62	Yes	Yes	1	8	5
85	V:V:I233	V:V:V216	13.6126	4.61	Yes	No	1	5	7
86	V:V:I231	V:V:I233	11.6317	2.94	Yes	Yes	1	7	5
87	V:V:F268	V:V:V262	11.6484	6.55	Yes	Yes	0	4	7
88	R:R:I298	R:R:V302	10.034	3.07	Yes	Yes	2	6	5
89	R:R:V302	R:R:W320	14.7464	2.45	Yes	Yes	2	5	4
90	R:R:A115	R:R:S156	10.7452	1.71	No	No	2	8	9
91	R:R:L112	R:R:Y338	17.5523	4.69	Yes	Yes	2	9	9
92	R:R:Y254	R:R:Y338	17.9385	2.98	Yes	Yes	2	9	9
93	R:R:M257	R:R:R167	18.8659	2.48	Yes	Yes	2	8	9
94	R:R:M163	R:R:Y338	10.5047	5.99	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:M153	4.79	2	Yes	Yes	0	7	0	1
L:L:Y1	R:R:K235	2.39	2	Yes	Yes	0	4	0	1
L:L:Y1	R:R:V238	10.09	2	Yes	No	0	5	0	1
L:L:Y1	R:R:V302	5.05	2	Yes	Yes	0	5	0	1
L:L:P2	R:R:I298	6.77	2	Yes	Yes	0	6	0	1
L:L:P2	R:R:V302	3.53	2	Yes	Yes	0	5	0	1
L:L:P2	R:R:W320	6.76	2	Yes	Yes	0	4	0	1
L:L:P2	R:R:I324	6.77	2	Yes	Yes	0	5	0	1
L:L:W3	R:R:Q126	10.95	2	Yes	Yes	0	6	0	1
L:L:W3	R:R:N129	3.39	2	Yes	No	0	4	0	1
L:L:W3	R:R:W135	5.62	2	Yes	Yes	0	8	0	1
L:L:W3	R:R:V145	4.9	2	Yes	Yes	0	5	0	1
L:L:W3	R:R:I146	7.05	2	Yes	Yes	0	4	0	1
L:L:W3	R:R:C219	7.84	2	Yes	Yes	0	9	0	1
L:L:F4	R:R:Y77	11.35	2	Yes	Yes	0	7	0	1
L:L:F4	R:R:Q126	9.37	2	Yes	Yes	0	6	0	1
L:L:F4	R:R:Y130	8.25	2	Yes	Yes	0	5	0	1
L:L:F4	R:R:W320	2	2	Yes	Yes	0	4	0	1
L:L:F4	R:R:H321	10.18	2	Yes	Yes	0	4	0	1
L:L:F4	R:R:I324	5.02	2	Yes	Yes	0	5	0	1
R:R:I73	R:R:Y77	3.63	2	Yes	Yes	6	7	2	1
R:R:I73	R:R:Y130	7.25	2	Yes	Yes	6	5	2	1
R:R:H321	R:R:I73	15.91	2	Yes	Yes	4	6	1	2
R:R:L123	R:R:Y77	2.34	2	Yes	Yes	7	7	2	1
R:R:S127	R:R:Y77	5.09	0	No	Yes	6	7	2	1
R:R:H321	R:R:Y77	7.62	2	Yes	Yes	4	7	1	1
R:R:I324	R:R:Y77	7.25	2	Yes	Yes	5	7	1	1
R:R:A325	R:R:Y77	2.67	0	No	Yes	6	7	2	1
R:R:Q126	R:R:T122	4.25	2	Yes	Yes	6	6	1	2
R:R:T122	R:R:V145	3.17	2	Yes	Yes	6	5	2	1
R:R:D149	R:R:T122	2.89	2	No	Yes	5	6	2	2
R:R:L123	R:R:Y328	14.07	2	Yes	Yes	7	7	2	2
R:R:F125	R:R:W135	6.01	2	Yes	Yes	6	8	2	1
R:R:F125	R:R:F137	15	2	Yes	Yes	6	6	2	2
R:R:F125	R:R:L141	2.44	2	Yes	No	6	5	2	2
R:R:F125	R:R:V145	7.87	2	Yes	Yes	6	5	2	1
R:R:D149	R:R:Q126	2.61	2	No	Yes	5	6	2	1
R:R:N129	R:R:W135	9.04	2	No	Yes	4	8	1	1
R:R:T317	R:R:Y130	3.75	2	No	Yes	4	5	2	1
R:R:H321	R:R:Y130	18.51	2	Yes	Yes	4	5	1	1
R:R:F137	R:R:W135	20.04	2	Yes	Yes	6	8	2	1
R:R:G138	R:R:W135	2.81	0	No	Yes	7	8	2	1
R:R:L141	R:R:W135	2.28	2	No	Yes	5	8	2	1
R:R:C142	R:R:W135	5.22	2	No	Yes	9	8	2	1
R:R:V145	R:R:W135	4.9	2	Yes	Yes	5	8	1	1
R:R:C219	R:R:W135	11.75	2	Yes	Yes	9	8	1	1
R:R:F137	R:R:L141	6.09	2	Yes	No	6	5	2	2
R:R:C142	R:R:C219	7.28	2	No	Yes	9	9	2	1
R:R:I146	R:R:Y150	2.42	2	Yes	No	4	4	1	2
R:R:I146	R:R:V204	3.07	2	Yes	Yes	4	5	1	2
R:R:A208	R:R:I146	3.25	0	No	Yes	5	4	2	1
R:R:C219	R:R:I146	3.27	2	Yes	Yes	9	4	1	1
R:R:D149	R:R:Y328	4.6	2	No	Yes	5	7	2	2
R:R:V204	R:R:Y150	5.05	2	Yes	No	5	4	2	2
R:R:F154	R:R:M153	6.22	2	Yes	Yes	6	7	2	1
R:R:I157	R:R:M153	2.92	2	Yes	Yes	7	7	2	1
R:R:M153	R:R:W295	2.33	2	Yes	Yes	7	8	1	2
R:R:F154	R:R:V238	6.55	2	Yes	No	6	5	2	1
R:R:A242	R:R:F154	4.16	2	No	Yes	5	6	2	2
R:R:I157	R:R:W295	7.05	2	Yes	Yes	7	8	2	2
R:R:K235	R:R:V302	6.07	2	Yes	Yes	4	5	1	1
R:R:A306	R:R:K235	4.82	0	No	Yes	4	4	2	1
R:R:A242	R:R:V238	1.7	2	No	No	5	5	2	1
R:R:I298	R:R:W295	2.35	2	Yes	Yes	6	8	1	2
R:R:I298	R:R:V302	3.07	2	Yes	Yes	6	5	1	1
R:R:C323	R:R:I298	3.27	0	No	Yes	6	6	2	1
R:R:W320	R:R:Y301	8.68	2	Yes	Yes	4	5	1	2
R:R:C323	R:R:Y301	2.69	0	No	Yes	6	5	2	2
R:R:V302	R:R:W320	2.45	2	Yes	Yes	5	4	1	1
R:R:K305	R:R:W320	5.8	2	No	Yes	3	4	2	1
R:R:H321	R:R:T317	2.74	2	Yes	No	4	4	1	2
R:R:H321	R:R:W320	5.29	2	Yes	Yes	4	4	1	1
R:R:I324	R:R:W320	2.35	2	Yes	Yes	5	4	1	1
R:R:I324	R:R:Y328	2.42	2	Yes	Yes	5	7	1	2
R:R:K235	R:R:N232	1.4	2	Yes	No	4	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9WSX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.64
Number of Linked Nodes	630
Number of Links	859
Number of Hubs	159
Number of Links mediated by Hubs	558
Number of Communities	19
Number of Nodes involved in Communities	262
Number of Links involved in Communities	412

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	6058971
Length Of Smallest Path	3
Average Path Length	29.8391
Length of Longest Path	45
Minimum Path Strength	1.13
Average Path Strength	4.93173
Maximum Path Strength	22.525
Minimum Path Correlation	0.7
Average Path Correlation	0.9907
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	37.4138
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	61.2058
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • binding • neuropeptide binding • peptide binding • protein binding • G-protein alpha-subunit binding • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • protein domain specific binding • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • G-protein beta-subunit binding • regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • transport • homeostatic process • fluid transport • establishment of localization • water transport • renal water transport • localization • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • trans-synaptic signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • G protein-coupled opioid receptor signaling pathway • multi-multicellular organism process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • negative regulation of cytosolic calcium ion concentration • negative regulation of signaling • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal development • positive regulation of cell development • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • neuropeptide signaling pathway • monosaccharide metabolic process • gluconeogenesis • regulation of primary metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of gluconeogenesis • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • regulation of gluconeogenesis • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • glucose metabolic process • locomotory behavior • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • intracellular signaling cassette • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of localization • regulation of signaling receptor activity • regulation of transmembrane transporter activity • regulation of NMDA receptor activity • regulation of transport • transmembrane transport • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of hormone levels • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • secretion • regulation of gonadotropin secretion • export from cell • hormone transport • eating behavior • feeding behavior • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • adenylate cyclase-inhibiting opioid receptor signaling pathway • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • regulation of nitric oxide metabolic process • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • biological process involved in intraspecies interaction between organisms • social behavior • sensory perception • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • regulation of protein localization • negative regulation of Wnt protein secretion • protein localization to extracellular region • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • establishment of protein localization to extracellular region • regulation of establishment of protein localization • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • negative regulation of protein secretion • protein transport • macromolecule localization • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • sarcoplasm • sarcoplasmic reticulum • axon • mitochondrion • anchoring junction • focal adhesion • cell-substrate junction • GABA-ergic synapse • neuron projection cytoplasm • dendrite cytoplasm • cell leading edge • leading edge membrane • neuron projection membrane • dendrite membrane • cell projection membrane • neuron spine • dendritic spine • spine apparatus • clathrin binding • protein binding • binding • protein-containing complex binding • AP-2 adaptor complex binding • clathrin heavy chain binding • signaling receptor binding • acetylcholine receptor binding • small molecule binding • ion binding • phosphatidylinositol-3,4,5-trisphosphate binding • anion binding • phospholipid binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol binding • molecular adaptor activity • G protein-coupled receptor binding • inositol hexakisphosphate binding • alcohol binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • cellular component organization • positive regulation of endocytosis • cellular component organization or biogenesis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception • nervous system process • clathrin-dependent endocytosis • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • catabolic process • primary metabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • metabolic process • protein metabolic process • macromolecule metabolic process • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of metabolic process • G protein-coupled receptor internalization • pseudopodium • protein-containing complex • plasma membrane protein complex • membrane protein complex • coated membrane • clathrin coat • membrane coat • clathrin-coated pit • clathrin coat of coated pit • cytosol • nucleus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Arrestin/Vps26-like
SCOP2	Family Identifier	• G protein-coupled receptor-like • Arrestin/Vps26-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	SEP
PDB Residues	R:R:?366 R:R:?371 R:R:?372 R:R:?373
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES
PubChem	57689797
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	TPO
PDB Residues	R:R:?368 R:R:?369
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>9WSX_nogp_Chain_R M T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F C V N V I E ?C ??A ?? ?L A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P17870
Sequence	>9WSX_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V E P V D G V V L V D P E Y L K E R R V Y V T L T C A F R Y G R E D L D V L G L T F R K D L F V A N V Q S F P P A P E D K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P C S V T L Q P G P E D T G K A C G V D Y E V K A F C A E N L E E K I H K R N S V R L V I K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I C L F N T A Q Y K C P V A M E E A D D T V A P S S T F C K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G G L L G D L A S S D V A V E L P F T L M H P K P K E E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

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