psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	16.69	Yes	Yes	0	0	0
2	L:L:Y1	R:R:D149	3.45	Yes	No	0	0	5
3	L:L:Y1	R:R:Y150	4.96	Yes	No	0	0	4
4	L:L:Y1	R:R:M153	7.18	Yes	No	0	0	7
5	L:L:Y1	R:R:V238	5.05	Yes	No	0	0	5
6	L:L:Y1	R:R:H299	7.62	Yes	Yes	0	0	7
7	L:L:Y1	R:R:V302	3.79	Yes	No	0	0	5
8	L:L:?2	L:L:G3	6.96	Yes	No	1	0	0
9	L:L:?2	R:R:I298	5.81	Yes	No	1	0	6
10	L:L:?2	R:R:W320	8.11	Yes	Yes	1	0	4
11	L:L:?2	R:R:I324	8.71	Yes	No	1	0	5
12	L:L:?4	L:L:G3	5.92	Yes	No	1	0	0
13	L:L:G3	R:R:Q126	3.29	No	Yes	1	0	6
14	L:L:?4	L:L:?5	19.37	Yes	No	0	0	0
15	L:L:?4	R:R:Q126	4.61	Yes	Yes	1	0	6
16	L:L:?4	R:R:N129	3.56	Yes	No	0	0	4
17	L:L:?4	R:R:V145	5.16	Yes	No	1	0	5
18	L:L:?4	R:R:I146	16.05	Yes	Yes	1	0	4
19	L:L:?4	R:R:D149	7.05	Yes	No	0	0	5
20	L:L:?5	R:R:T220	3.97	No	No	0	0	4
21	R:R:I71	R:R:S66	4.64	No	No	0	5	7
22	R:R:I73	R:R:Y130	15.71	No	Yes	1	6	5
23	R:R:H321	R:R:I73	15.91	Yes	No	1	4	6
24	R:R:M74	R:R:Y130	3.59	Yes	Yes	0	5	5
25	R:R:L131	R:R:M74	8.48	No	Yes	0	4	5
26	R:R:F322	R:R:L76	3.65	No	No	0	4	5
27	R:R:L123	R:R:Y77	3.52	Yes	Yes	1	7	7
28	R:R:Q126	R:R:Y77	4.51	Yes	Yes	1	6	7
29	R:R:S127	R:R:Y77	5.09	No	Yes	0	6	7
30	R:R:H321	R:R:Y77	11.98	Yes	Yes	1	4	7
31	R:R:I324	R:R:Y77	8.46	No	Yes	1	5	7
32	R:R:T329	R:R:V80	3.17	No	No	0	5	7
33	R:R:C332	R:R:V80	3.42	Yes	No	0	8	7
34	R:R:C81	R:R:L85	3.17	No	No	0	6	6
35	R:R:C81	R:R:L123	4.76	No	Yes	0	6	7
36	R:R:C81	R:R:P124	3.77	No	No	0	6	8
37	R:R:C332	R:R:V83	3.42	Yes	No	0	8	5
38	R:R:G84	R:R:T120	3.64	No	No	0	8	5
39	R:R:C332	R:R:G84	3.92	Yes	No	0	8	8
40	R:R:F89	R:R:L85	3.65	No	No	0	4	6
41	R:R:F86	R:R:L90	10.96	No	No	0	5	6
42	R:R:D116	R:R:N88	6.73	Yes	No	0	9	9
43	R:R:A117	R:R:N88	4.69	No	No	0	7	9
44	R:R:N88	R:R:P335	4.89	No	No	0	9	9
45	R:R:A113	R:R:V91	3.39	No	No	0	9	9
46	R:R:A339	R:R:V91	3.39	No	No	17	6	9
47	R:R:F345	R:R:V91	5.24	Yes	No	17	8	9
48	R:R:F110	R:R:M92	8.71	No	No	0	6	7
49	R:R:R97	R:R:Y93	12.35	No	No	12	5	4
50	R:R:Y93	R:R:Y98	13.9	No	No	12	4	4
51	R:R:F352	R:R:Y93	4.13	No	No	12	7	4
52	R:R:F345	R:R:V94	9.18	Yes	No	0	8	7
53	R:R:I95	R:R:N106	4.25	No	No	0	7	8
54	R:R:F110	R:R:I95	5.02	No	No	0	6	7
55	R:R:F345	R:R:I95	5.02	Yes	No	0	8	7
56	R:R:R97	R:R:Y98	11.32	No	No	12	5	4
57	R:R:F352	R:R:Y98	7.22	No	No	12	7	4
58	R:R:N106	R:R:T99	7.31	No	No	0	8	6
59	R:R:C348	R:R:T99	5.07	No	No	0	6	6
60	R:R:K100	R:R:K102	14.37	No	No	0	6	7
61	R:R:F110	R:R:M101	4.98	No	No	0	6	7
62	R:R:N106	R:R:T103	7.31	No	No	0	8	7
63	R:R:T103	V:V:R65	5.17	No	No	0	7	7
64	R:R:T103	V:V:D69	5.78	No	Yes	0	7	9
65	R:R:R181	R:R:T105	3.88	Yes	No	0	7	8
66	R:R:T105	V:V:D69	7.23	No	Yes	0	8	9
67	R:R:A186	R:R:I107	4.87	No	No	0	7	5
68	R:R:I107	R:R:K187	4.36	No	No	0	5	2
69	R:R:I107	R:R:N190	4.25	No	No	0	5	7
70	R:R:M163	R:R:Y108	3.59	No	Yes	0	9	7
71	R:R:D166	R:R:Y108	6.9	No	Yes	0	8	7
72	R:R:A186	R:R:Y108	5.34	No	Yes	0	7	7
73	R:R:V189	R:R:Y108	8.83	No	Yes	0	5	7
74	R:R:N111	R:R:T159	7.31	No	No	0	9	8
75	R:R:N111	R:R:N190	14.98	No	No	0	9	7
76	R:R:N111	R:R:W194	12.43	No	No	0	9	9
77	R:R:D116	R:R:L112	5.43	Yes	Yes	16	9	9
78	R:R:L112	R:R:T159	5.9	Yes	No	0	9	8
79	R:R:L112	R:R:M163	4.24	Yes	No	0	9	9
80	R:R:L112	R:R:N334	5.49	Yes	No	16	9	9
81	R:R:L114	R:R:L118	5.54	No	No	0	7	7
82	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
83	R:R:D116	R:R:S156	5.89	Yes	No	0	9	9
84	R:R:D116	R:R:S331	11.78	Yes	No	0	9	9
85	R:R:D116	R:R:N334	6.73	Yes	No	16	9	9
86	R:R:L118	R:R:N152	12.36	No	No	0	7	8
87	R:R:S331	R:R:T120	4.8	No	No	0	9	5
88	R:R:Q126	R:R:T122	4.25	Yes	Yes	1	6	6
89	R:R:T122	R:R:Y328	3.75	Yes	Yes	1	6	7
90	R:R:L123	R:R:Q126	3.99	Yes	Yes	1	7	6
91	R:R:L123	R:R:Y328	19.93	Yes	Yes	1	7	7
92	R:R:F125	R:R:W135	4.01	No	Yes	1	6	8
93	R:R:F125	R:R:F137	6.43	No	Yes	1	6	6
94	R:R:F125	R:R:V145	13.11	No	No	1	6	5
95	R:R:Q126	R:R:Y328	10.15	Yes	Yes	1	6	7
96	R:R:L131	R:R:V128	5.96	No	No	0	4	3
97	R:R:N129	R:R:W135	9.04	No	Yes	0	4	8
98	R:R:H321	R:R:Y130	6.53	Yes	Yes	1	4	5
99	R:R:L131	R:R:M132	4.24	No	No	0	4	4
100	R:R:M132	R:R:P136	10.06	No	No	0	4	3
101	R:R:S216	R:R:T134	6.4	No	Yes	0	1	5
102	R:R:I217	R:R:T134	7.6	No	Yes	0	4	5
103	R:R:F137	R:R:W135	16.04	Yes	Yes	1	6	8
104	R:R:C142	R:R:W135	5.22	Yes	Yes	1	9	8
105	R:R:V145	R:R:W135	4.9	No	Yes	1	5	8
106	R:R:C219	R:R:W135	13.06	No	Yes	1	9	8
107	R:R:F137	R:R:P136	10.11	Yes	No	0	6	3
108	R:R:F137	R:R:L141	6.09	Yes	No	0	6	5
109	R:R:G138	R:R:L141	3.42	No	No	0	7	5
110	R:R:I140	R:R:N139	5.66	No	No	0	1	3
111	R:R:K143	R:R:N139	6.99	No	No	0	6	3
112	R:R:C142	R:R:I146	3.27	Yes	Yes	1	9	4
113	R:R:C142	R:R:T210	3.38	Yes	No	0	9	4
114	R:R:C142	R:R:C219	7.28	Yes	No	1	9	9
115	R:R:A208	R:R:I146	6.5	No	Yes	0	5	4
116	R:R:C219	R:R:I146	3.27	No	Yes	1	9	4
117	R:R:M205	R:R:S147	9.2	No	No	0	5	6
118	R:R:I148	R:R:N152	4.25	No	No	0	5	8
119	R:R:D149	R:R:Y328	3.45	No	Yes	0	5	7
120	R:R:V204	R:R:Y150	11.36	No	No	0	5	4
121	R:R:L221	R:R:Y150	3.52	No	No	0	4	4
122	R:R:T155	R:R:Y151	3.75	Yes	No	19	7	5
123	R:R:W194	R:R:Y151	10.61	No	No	19	9	5
124	R:R:S198	R:R:Y151	8.9	No	No	0	4	5
125	R:R:I157	R:R:M153	4.37	No	No	0	7	7
126	R:R:M153	R:R:W295	8.14	No	Yes	0	7	8
127	R:R:F154	R:R:F158	3.22	Yes	No	0	6	5
128	R:R:F154	R:R:I200	12.56	Yes	No	0	6	5
129	R:R:F154	R:R:V238	7.87	Yes	No	0	6	5
130	R:R:A242	R:R:F154	5.55	No	Yes	0	5	6
131	R:R:T155	R:R:W194	14.55	Yes	No	19	7	9
132	R:R:S197	R:R:T155	6.4	No	Yes	0	8	7
133	R:R:I157	R:R:P246	5.08	No	No	0	7	8
134	R:R:F158	R:R:S197	3.96	No	No	0	5	8
135	R:R:L160	R:R:Y338	5.86	No	Yes	0	8	9
136	R:R:C161	R:R:P246	3.77	No	No	0	7	8
137	R:R:C161	R:R:I249	3.27	No	No	0	7	6
138	R:R:T162	R:R:V189	4.76	No	No	18	7	5
139	R:R:N193	R:R:T162	7.31	No	No	18	7	7
140	R:R:M163	R:R:Y338	4.79	No	Yes	0	9	9
141	R:R:I250	R:R:S164	4.64	No	No	0	8	9
142	R:R:C253	R:R:S164	3.44	No	No	0	8	9
143	R:R:S164	R:R:Y254	8.9	No	Yes	0	9	9
144	R:R:C253	R:R:V165	3.42	No	No	0	8	6
145	R:R:D166	R:R:R181	10.72	No	Yes	0	8	7
146	R:R:R167	R:R:Y254	6.17	No	Yes	0	9	9
147	R:R:R167	R:R:Y338	9.26	No	Yes	0	9	9
148	R:R:R167	V:V:L71	6.07	No	Yes	0	9	8
149	R:R:I169	R:R:Y168	3.63	No	Yes	0	5	8
150	R:R:C172	R:R:Y168	6.72	No	Yes	0	7	8
151	R:R:H173	R:R:Y168	6.53	No	Yes	0	6	8
152	R:R:C253	R:R:Y168	5.38	No	Yes	0	8	8
153	R:R:L256	R:R:Y168	7.03	No	Yes	0	5	8
154	R:R:A170	R:R:R181	5.53	No	Yes	0	8	7
155	R:R:M257	R:R:V171	7.61	No	No	0	8	8
156	R:R:C172	R:R:R260	8.36	No	No	0	7	5
157	R:R:P174	V:V:Y63	8.34	No	Yes	0	8	8
158	R:R:V175	V:V:I241	4.61	No	No	0	6	7
159	R:R:F180	R:R:K176	16.13	No	No	0	3	4
160	R:R:R181	V:V:V70	3.92	Yes	No	0	7	7
161	R:R:P183	R:R:T182	3.5	No	No	0	1	7
162	R:R:T182	V:V:R285	7.76	No	No	0	7	5
163	R:R:K187	R:R:P183	3.35	No	No	0	2	1
164	R:R:N185	R:R:R184	3.62	No	No	0	4	3
165	R:R:I188	R:R:R184	6.26	No	No	0	3	3
166	R:R:N193	R:R:V189	4.43	No	No	18	7	5
167	R:R:C192	R:R:L196	3.17	No	No	0	2	4
168	R:R:F206	R:R:L202	3.65	No	No	0	4	4
169	R:R:F223	R:R:M207	19.9	Yes	No	0	6	5
170	R:R:T209	R:R:T222	7.85	No	No	0	5	4
171	R:R:D218	R:R:K211	6.91	No	No	0	4	1
172	R:R:K211	R:R:T220	7.51	No	No	0	1	4
173	R:R:Q214	R:R:R213	5.84	No	No	0	2	2
174	R:R:D218	R:R:R213	7.15	No	No	0	4	2
175	R:R:F223	R:R:H225	9.05	Yes	No	21	6	2
176	R:R:F223	R:R:W230	21.05	Yes	No	21	6	1
177	R:R:E231	R:R:F223	8.16	No	Yes	0	4	6
178	R:R:H225	R:R:W230	23.27	No	No	21	2	1
179	R:R:E231	R:R:T227	4.23	No	No	0	4	3
180	R:R:N232	R:R:W228	7.91	No	No	0	2	1
181	R:R:W230	R:R:Y229	10.61	No	No	0	1	1
182	R:R:L233	R:R:Y229	4.69	No	No	0	3	1
183	R:R:C237	R:R:L233	3.17	No	No	0	5	3
184	R:R:K235	R:R:V302	6.07	No	No	0	4	5
185	R:R:A306	R:R:K235	4.82	No	No	0	4	4
186	R:R:F239	R:R:I236	5.02	Yes	No	0	6	4
187	R:R:F239	R:R:F243	8.57	Yes	Yes	15	6	8
188	R:R:F239	R:R:H299	4.53	Yes	Yes	15	6	7
189	R:R:F239	R:R:I303	7.54	Yes	No	0	6	5
190	R:R:F241	R:R:I240	7.54	No	No	0	4	5
191	R:R:I240	R:R:I244	5.89	No	No	0	5	4
192	R:R:F243	R:R:I244	5.02	Yes	No	0	8	4
193	R:R:F243	R:R:T296	7.78	Yes	No	0	8	5
194	R:R:F243	R:R:H299	13.58	Yes	Yes	15	8	7
195	R:R:F291	R:R:I250	3.77	No	No	0	9	8
196	R:R:M257	R:R:Y254	4.79	No	Yes	0	8	9
197	R:R:V284	R:R:Y254	3.79	No	Yes	0	8	9
198	R:R:V288	R:R:Y254	3.79	No	Yes	0	8	9
199	R:R:R260	V:V:F244	13.9	No	No	0	5	7
200	R:R:K262	R:R:L277	8.46	No	No	8	4	6
201	R:R:K262	R:R:R278	7.43	No	Yes	8	4	5
202	R:R:S263	V:V:F244	5.28	No	No	0	3	7
203	R:R:E272	R:R:N276	9.2	No	No	0	3	5
204	R:R:L277	R:R:R278	3.64	No	Yes	8	6	5
205	R:R:E343	R:R:R279	4.65	Yes	No	0	5	7
206	R:R:L341	R:R:M283	7.07	No	No	0	7	8
207	R:R:M283	V:V:L71	4.24	No	Yes	0	8	8
208	R:R:V287	R:R:Y338	3.79	No	Yes	0	8	9
209	R:R:F291	R:R:W295	6.01	No	Yes	0	9	8
210	R:R:H299	R:R:W295	4.23	Yes	Yes	0	7	8
211	R:R:N330	R:R:W295	7.91	No	Yes	0	9	8
212	R:R:P297	R:R:T296	3.5	No	No	0	9	5
213	R:R:I298	R:R:W320	3.52	No	Yes	1	6	4
214	R:R:C323	R:R:I298	3.27	No	No	0	6	6
215	R:R:K305	R:R:Y301	5.97	Yes	Yes	1	3	5
216	R:R:Q316	R:R:Y301	10.15	Yes	Yes	1	3	5
217	R:R:S319	R:R:Y301	6.36	No	Yes	0	4	5
218	R:R:W320	R:R:Y301	7.72	Yes	Yes	1	4	5
219	R:R:I310	R:R:K305	4.36	Yes	Yes	1	4	3
220	R:R:K305	R:R:Q316	5.42	Yes	Yes	1	3	3
221	R:R:K305	R:R:W320	5.8	Yes	Yes	1	3	4
222	R:R:I310	R:R:P311	5.08	Yes	No	0	4	1
223	R:R:I310	R:R:Q316	10.98	Yes	Yes	1	4	3
224	R:R:H321	R:R:W320	3.17	Yes	Yes	1	4	4
225	R:R:I324	R:R:W320	5.87	No	Yes	1	5	4
226	R:R:F322	R:R:L326	9.74	No	No	0	4	8
227	R:R:L326	R:R:T329	4.42	No	No	0	8	5
228	R:R:N330	R:R:N334	8.17	No	No	0	9	9
229	R:R:A339	R:R:F345	8.32	No	Yes	17	6	8
230	R:R:F340	R:R:F345	11.79	No	Yes	0	6	8
231	R:R:F340	R:R:F349	5.36	No	No	0	6	6
232	R:R:D342	R:R:F345	3.58	No	Yes	0	8	8
233	R:R:E343	V:V:G72	4.91	Yes	No	0	5	9
234	R:R:N344	R:R:R347	9.64	No	No	0	7	5
235	R:R:N344	V:V:D69	8.08	No	Yes	0	7	9
236	R:R:K346	R:R:R350	6.19	No	No	0	8	5
237	R:R:C348	R:R:R347	4.18	No	No	0	6	5
238	R:R:E351	R:R:R347	5.82	No	No	0	3	5
239	R:R:F349	R:R:F352	3.22	No	No	0	6	7
240	R:R:C353	R:R:F349	4.19	No	No	0	5	6
241	R:R:E365	V:V:P14	11	No	No	0	3	4
242	R:R:E365	V:V:K160	10.8	No	No	0	3	6
243	R:R:E365	V:V:R161	3.49	No	No	0	3	7
244	R:R:?366	V:V:K11	6	No	Yes	0	6	9
245	R:R:?366	V:V:R165	7.23	No	No	0	6	5
246	R:R:?368	R:R:C367	5.21	No	No	0	4	5
247	R:R:?368	R:R:?369	20.53	No	Yes	0	4	6
248	R:R:?369	V:V:K11	17.37	Yes	Yes	9	6	9
249	R:R:?369	V:V:R25	13.97	Yes	Yes	9	6	9
250	R:R:?369	V:V:L166	5.68	Yes	Yes	9	6	8
251	R:R:?369	V:V:K294	9.26	Yes	No	9	6	8
252	R:R:?371	R:R:A370	4.02	Yes	No	0	4	7
253	R:R:?371	R:R:?372	17.02	Yes	Yes	3	4	7
254	R:R:?371	V:V:R7	18.6	Yes	No	3	4	5
255	R:R:?371	V:V:K10	4.8	Yes	No	3	4	9
256	R:R:?372	R:R:?373	26.02	Yes	Yes	3	7	5
257	R:R:?372	V:V:R7	16.53	Yes	No	3	7	5
258	R:R:?372	V:V:V8	5.07	Yes	No	0	7	7
259	R:R:?372	V:V:K10	9.59	Yes	No	3	7	9
260	R:R:?372	V:V:K107	9.59	Yes	No	3	7	9
261	R:R:?373	R:R:L374	4.71	Yes	Yes	3	5	5
262	R:R:?373	V:V:R7	12.4	Yes	No	3	5	5
263	R:R:?373	V:V:K107	4.8	Yes	No	3	5	9
264	R:R:L374	V:V:T6	4.42	Yes	No	3	5	5
265	R:R:L374	V:V:R103	13.36	Yes	Yes	3	5	5
266	R:R:L374	V:V:L104	4.15	Yes	Yes	0	5	9
267	R:R:K376	V:V:R103	8.66	No	Yes	0	5	5
268	V:V:R103	V:V:T6	11.64	Yes	No	3	5	5
269	V:V:L104	V:V:V8	7.45	Yes	No	0	9	7
270	V:V:F9	V:V:R25	9.62	No	Yes	0	7	9
271	V:V:K10	V:V:Y21	13.14	No	Yes	0	9	8
272	V:V:K11	V:V:V164	4.55	Yes	No	0	9	8
273	V:V:K11	V:V:L166	7.05	Yes	Yes	9	9	8
274	V:V:A12	V:V:T19	3.36	No	No	0	5	6
275	V:V:P14	V:V:S13	5.34	No	Yes	0	4	8
276	V:V:N15	V:V:S13	5.96	Yes	Yes	0	9	8
277	V:V:K17	V:V:N15	8.39	No	Yes	6	6	9
278	V:V:N15	V:V:Y47	5.81	Yes	Yes	6	9	5
279	V:V:N15	V:V:N162	10.9	Yes	Yes	6	9	8
280	V:V:D44	V:V:K17	11.06	No	No	6	7	6
281	V:V:K17	V:V:Y47	19.11	No	Yes	6	6	5
282	V:V:T19	V:V:Y21	8.74	No	Yes	0	6	8
283	V:V:L42	V:V:T19	4.42	No	No	0	4	6
284	V:V:V164	V:V:V20	3.21	No	No	0	8	5
285	V:V:L104	V:V:Y21	4.69	Yes	Yes	0	9	8
286	V:V:L108	V:V:Y21	12.89	Yes	Yes	0	7	8
287	V:V:G23	V:V:L100	5.13	No	No	0	5	5
288	V:V:F27	V:V:K24	9.93	No	No	0	7	7
289	V:V:E35	V:V:K24	8.1	Yes	No	0	6	7
290	V:V:L166	V:V:R25	4.86	Yes	Yes	9	8	9
291	V:V:L293	V:V:R25	13.36	No	Yes	0	6	9
292	V:V:K294	V:V:R25	3.71	No	Yes	9	8	9
293	V:V:D26	V:V:E169	6.5	No	No	0	8	9
294	V:V:F27	V:V:V37	15.73	No	No	0	7	7
295	V:V:F27	V:V:I168	6.28	No	No	0	7	8
296	V:V:H30	V:V:V28	6.92	No	No	7	5	6
297	V:V:E35	V:V:V28	8.56	Yes	No	7	6	6
298	V:V:V28	V:V:Y173	7.57	No	Yes	7	6	4
299	V:V:D29	V:V:V34	7.3	Yes	No	4	8	6
300	V:V:C125	V:V:D29	4.67	No	Yes	4	5	8
301	V:V:D29	V:V:K170	17.97	Yes	Yes	4	8	9
302	V:V:D29	V:V:Q172	11.75	Yes	No	4	8	9
303	V:V:D32	V:V:H30	3.78	No	No	0	4	5
304	V:V:E35	V:V:H30	6.15	Yes	No	7	6	5
305	V:V:I31	V:V:R307	3.76	No	No	0	4	3
306	V:V:D32	V:V:L33	12.21	No	No	0	4	2
307	V:V:I119	V:V:V34	7.68	No	No	0	5	6
308	V:V:K170	V:V:V34	6.07	Yes	No	4	9	6
309	V:V:D38	V:V:T98	10.12	No	No	10	7	7
310	V:V:D38	V:V:Q101	5.22	No	Yes	10	7	9
311	V:V:F115	V:V:G39	7.53	Yes	No	0	8	8
312	V:V:L104	V:V:V40	7.45	Yes	No	0	9	7
313	V:V:S86	V:V:V41	3.23	No	No	0	5	4
314	V:V:L108	V:V:L42	4.15	Yes	No	0	7	4
315	V:V:V43	V:V:V53	4.81	No	No	0	5	7
316	V:V:D44	V:V:E46	5.2	No	No	0	7	4
317	V:V:D44	V:V:Y47	8.05	No	Yes	6	7	5
318	V:V:E46	V:V:P45	4.72	No	No	0	4	3
319	V:V:H111	V:V:P45	12.2	No	No	0	6	3
320	V:V:L48	V:V:Y47	3.52	Yes	Yes	6	4	5
321	V:V:R51	V:V:Y47	14.4	Yes	Yes	6	7	5
322	V:V:N162	V:V:Y47	10.47	Yes	Yes	6	8	5
323	V:V:L48	V:V:R51	6.07	Yes	Yes	6	4	7
324	V:V:F87	V:V:L48	3.65	Yes	Yes	0	5	4
325	V:V:C150	V:V:L48	4.76	No	Yes	0	5	4
326	V:V:E50	V:V:K49	8.1	No	No	0	3	5
327	V:V:E152	V:V:R51	4.65	No	Yes	0	4	7
328	V:V:N162	V:V:R51	3.62	Yes	Yes	6	8	7
329	V:V:R52	V:V:Y54	11.32	No	Yes	14	7	4
330	V:V:Q85	V:V:R52	5.84	Yes	No	14	9	7
331	V:V:P88	V:V:R52	5.76	No	No	14	9	7
332	V:V:F87	V:V:V53	3.93	Yes	No	0	5	7
333	V:V:C150	V:V:V53	3.42	No	No	0	5	7
334	V:V:Q85	V:V:Y54	4.51	Yes	Yes	14	9	4
335	V:V:F149	V:V:Y54	8.25	Yes	Yes	0	5	4
336	V:V:L154	V:V:Y54	10.55	No	Yes	0	2	4
337	V:V:S86	V:V:V55	4.85	No	Yes	13	5	6
338	V:V:F115	V:V:V55	15.73	Yes	Yes	13	8	6
339	V:V:F117	V:V:V55	5.24	Yes	Yes	13	7	6
340	V:V:F149	V:V:T56	5.19	Yes	Yes	0	5	6
341	V:V:F80	V:V:L57	3.65	Yes	No	0	4	6
342	V:V:F117	V:V:L57	13.4	Yes	No	0	7	6
343	V:V:D78	V:V:T58	7.23	No	No	22	7	5
344	V:V:T58	V:V:V81	7.93	No	No	22	5	4
345	V:V:C59	V:V:L79	6.35	No	Yes	0	6	6
346	V:V:C59	V:V:F80	4.19	No	Yes	0	6	4
347	V:V:C59	V:V:Y144	12.1	No	No	0	6	7
348	V:V:A60	V:V:R76	5.53	No	No	0	8	6
349	V:V:F61	V:V:Y63	4.13	Yes	Yes	20	9	8
350	V:V:F61	V:V:L79	3.65	Yes	Yes	0	9	6
351	V:V:F61	V:V:V142	5.24	Yes	No	0	9	9
352	V:V:F61	V:V:I241	3.77	Yes	No	0	9	7
353	V:V:F61	V:V:L243	3.65	Yes	No	20	9	7
354	V:V:E66	V:V:R62	15.12	No	No	23	8	8
355	V:V:R62	V:V:R76	5.33	No	No	0	8	6
356	V:V:K138	V:V:R62	3.71	Yes	No	23	7	8
357	V:V:F75	V:V:Y63	5.16	No	Yes	0	8	8
358	V:V:K77	V:V:Y63	5.97	No	Yes	0	8	8
359	V:V:L243	V:V:Y63	11.72	No	Yes	20	7	8
360	V:V:D67	V:V:R65	23.82	No	No	0	8	7
361	V:V:R65	V:V:T136	19.41	No	No	0	7	2
362	V:V:E66	V:V:K138	10.8	No	Yes	23	8	7
363	V:V:D67	V:V:D69	11.98	No	Yes	0	8	9
364	V:V:G72	V:V:L68	5.13	No	No	0	9	7
365	V:V:L71	V:V:V70	4.47	Yes	No	0	8	7
366	V:V:F75	V:V:V70	6.55	No	No	0	8	7
367	V:V:F75	V:V:L73	4.87	No	No	0	8	6
368	V:V:D78	V:V:R76	13.1	No	No	0	7	6
369	V:V:K77	V:V:L79	4.23	No	Yes	0	8	6
370	V:V:D78	V:V:V81	4.38	No	No	22	7	4
371	V:V:L79	V:V:P124	3.28	Yes	Yes	0	6	8
372	V:V:L315	V:V:L79	4.15	No	Yes	0	5	6
373	V:V:A82	V:V:F80	4.16	No	Yes	0	4	4
374	V:V:F80	V:V:P120	8.67	Yes	No	4	4	6
375	V:V:F80	V:V:L123	4.87	Yes	Yes	4	4	6
376	V:V:F117	V:V:V84	3.93	Yes	No	0	7	3
377	V:V:P88	V:V:Q85	4.74	No	Yes	14	9	9
378	V:V:F115	V:V:S86	3.96	Yes	No	13	8	5
379	V:V:F87	V:V:P88	4.33	Yes	No	0	5	9
380	V:V:F87	V:V:Y113	13.41	Yes	No	0	5	3
381	V:V:P89	V:V:Y113	5.56	No	No	0	3	3
382	V:V:E92	V:V:P91	7.86	No	No	0	2	1
383	V:V:D93	V:V:K95	4.15	No	No	0	1	1
384	V:V:E118	V:V:K95	8.1	No	No	0	4	1
385	V:V:L97	V:V:Q101	5.32	No	Yes	10	3	9
386	V:V:E102	V:V:L97	6.63	No	No	0	6	3
387	V:V:L97	V:V:P114	3.28	No	No	10	3	7
388	V:V:Q101	V:V:T98	7.09	Yes	No	10	9	7
389	V:V:E102	V:V:R99	6.98	No	No	0	6	4
390	V:V:R103	V:V:R99	7.46	Yes	No	0	5	4
391	V:V:P114	V:V:Q101	7.9	No	Yes	10	7	9
392	V:V:I105	V:V:P114	5.08	No	No	0	3	7
393	V:V:K107	V:V:L108	4.23	No	Yes	0	9	7
394	V:V:A112	V:V:L108	4.73	No	Yes	0	8	7
395	V:V:E110	V:V:H111	9.85	No	No	0	2	6
396	V:V:F115	V:V:F117	5.36	Yes	Yes	13	8	7
397	V:V:E118	V:V:T116	5.64	No	No	0	4	3
398	V:V:I119	V:V:P120	3.39	No	No	0	5	6
399	V:V:L123	V:V:P120	4.93	Yes	No	4	6	6
400	V:V:N122	V:V:R307	6.03	No	No	0	5	3
401	V:V:A310	V:V:N122	4.69	No	No	0	3	5
402	V:V:I314	V:V:N122	4.25	No	No	0	4	5
403	V:V:L123	V:V:P124	3.28	Yes	Yes	0	6	8
404	V:V:K170	V:V:L123	5.64	Yes	Yes	4	9	6
405	V:V:P124	V:V:V142	7.07	Yes	No	0	8	9
406	V:V:G316	V:V:P124	4.06	No	Yes	0	8	8
407	V:V:C125	V:V:K170	3.23	No	Yes	4	5	9
408	V:V:C125	V:V:Q172	6.1	No	No	4	5	9
409	V:V:E169	V:V:S126	5.75	No	No	0	9	9
410	V:V:I317	V:V:V127	7.68	No	No	0	8	8
411	V:V:V127	V:V:V319	3.21	No	Yes	0	8	8
412	V:V:G291	V:V:T128	5.46	No	No	0	8	6
413	V:V:C140	V:V:L129	3.17	No	No	0	6	7
414	V:V:I317	V:V:L129	4.28	No	No	0	8	7
415	V:V:L287	V:V:Q130	7.99	No	No	0	6	8
416	V:V:L289	V:V:Q130	6.65	No	No	0	7	8
417	V:V:D135	V:V:P131	8.05	No	No	0	6	5
418	V:V:G132	V:V:P133	4.06	No	No	0	5	3
419	V:V:D135	V:V:T136	5.78	No	No	0	6	2
420	V:V:G137	V:V:T136	3.64	No	No	0	5	2
421	V:V:A139	V:V:K138	3.21	No	Yes	0	4	7
422	V:V:K170	V:V:Y144	16.72	Yes	No	0	9	7
423	V:V:E145	V:V:R165	13.96	No	No	0	7	5
424	V:V:E145	V:V:V167	7.13	No	No	0	7	5
425	V:V:K147	V:V:S163	9.18	No	No	0	5	8
426	V:V:K147	V:V:R165	13.61	No	No	0	5	5
427	V:V:F149	V:V:I158	13.82	Yes	No	0	5	3
428	V:V:E155	V:V:N153	7.89	No	No	0	5	4
429	V:V:E156	V:V:N153	7.89	No	No	0	6	4
430	V:V:H159	V:V:K157	11.79	No	No	0	5	5
431	V:V:H159	V:V:K160	6.55	No	No	0	5	6
432	V:V:H159	V:V:R161	14.67	No	No	0	5	7
433	V:V:N162	V:V:R161	3.62	Yes	No	0	8	7
434	V:V:E169	V:V:L293	7.95	No	No	0	9	6
435	V:V:V171	V:V:Y173	3.79	No	Yes	0	6	4
436	V:V:L305	V:V:Q172	5.32	No	No	0	5	9
437	V:V:K355	V:V:Y173	7.17	No	Yes	7	6	4
438	V:V:P356	V:V:Y173	15.3	No	Yes	7	7	4
439	V:V:I207	V:V:P175	6.77	No	No	0	4	8
440	V:V:L305	V:V:P175	4.93	No	No	0	5	8
441	V:V:G179	V:V:P180	4.06	No	No	0	2	4
442	V:V:E206	V:V:G179	4.91	No	No	0	7	2
443	V:V:L203	V:V:P182	13.14	Yes	No	0	9	8
444	V:V:S202	V:V:T183	3.2	No	No	0	6	4
445	V:V:A184	V:V:V345	5.09	No	Yes	0	5	6
446	V:V:E185	V:V:H198	13.54	No	Yes	25	6	5
447	V:V:E185	V:V:E200	13.95	No	No	25	6	7
448	V:V:T186	V:V:V345	4.76	No	Yes	0	6	6
449	V:V:P196	V:V:T187	3.5	No	No	0	5	4
450	V:V:H198	V:V:T187	6.85	Yes	No	0	5	4
451	V:V:F190	V:V:R188	7.48	No	No	0	9	7
452	V:V:R188	V:V:S341	3.95	No	No	0	7	8
453	V:V:R188	V:V:V343	6.54	No	No	0	7	6
454	V:V:M192	V:V:Q189	6.8	No	No	0	7	5
455	V:V:P196	V:V:Q189	7.9	No	No	0	5	5
456	V:V:F190	V:V:K226	4.96	No	No	0	9	8
457	V:V:F190	V:V:V329	9.18	No	No	0	9	5
458	V:V:D194	V:V:K195	6.91	No	No	0	6	7
459	V:V:K195	V:V:N223	4.2	No	No	0	7	6
460	V:V:L197	V:V:N222	5.49	No	No	0	7	9
461	V:V:L197	V:V:V343	4.47	No	No	0	7	6
462	V:V:E200	V:V:H198	12.31	No	Yes	25	7	5
463	V:V:H198	V:V:T221	8.21	Yes	No	0	5	5
464	V:V:L199	V:V:L327	8.3	No	No	0	7	7
465	V:V:L199	V:V:V345	7.45	No	Yes	0	7	6
466	V:V:E200	V:V:H219	12.31	No	No	0	7	4
467	V:V:A201	V:V:V325	3.39	No	Yes	0	6	7
468	V:V:A201	V:V:L347	4.73	No	No	0	6	6
469	V:V:L203	V:V:Y208	7.03	Yes	Yes	2	9	7
470	V:V:L203	V:V:V216	4.47	Yes	No	0	9	7
471	V:V:L203	V:V:L347	6.92	Yes	No	0	9	6
472	V:V:F349	V:V:L203	3.65	Yes	Yes	2	8	9
473	V:V:D204	V:V:K205	5.53	No	No	2	6	8
474	V:V:D204	V:V:Y208	12.64	No	Yes	2	6	7
475	V:V:D204	V:V:S215	7.36	No	No	0	6	3
476	V:V:K205	V:V:Y208	13.14	No	Yes	2	8	7
477	V:V:E212	V:V:K205	8.1	Yes	No	2	7	8
478	V:V:E206	V:V:I207	4.1	No	No	24	7	4
479	V:V:E206	V:V:T350	4.23	No	Yes	24	7	5
480	V:V:I207	V:V:T350	6.08	No	Yes	24	4	5
481	V:V:E212	V:V:Y208	4.49	Yes	Yes	2	7	7
482	V:V:I214	V:V:Y208	14.51	No	Yes	2	7	7
483	V:V:F349	V:V:Y208	8.25	Yes	Yes	2	8	7
484	V:V:E212	V:V:Y209	4.49	Yes	No	0	7	5
485	V:V:P354	V:V:Y209	22.25	No	No	0	7	5
486	V:V:H210	V:V:N299	14.03	Yes	No	2	9	8
487	V:V:H210	V:V:S302	6.97	Yes	No	0	9	9
488	V:V:H210	V:V:L351	9	Yes	No	2	9	8
489	V:V:H210	V:V:H353	17.91	Yes	No	2	9	8
490	V:V:E212	V:V:P213	4.72	Yes	No	0	7	4
491	V:V:I214	V:V:P276	5.08	No	No	0	7	9
492	V:V:F349	V:V:I214	5.02	Yes	No	2	8	7
493	V:V:S215	V:V:T273	3.2	No	No	0	3	3
494	V:V:I233	V:V:V216	4.61	Yes	No	0	5	7
495	V:V:V216	V:V:V323	3.21	No	No	0	7	5
496	V:V:C269	V:V:N217	4.72	No	No	0	5	6
497	V:V:N217	V:V:V271	4.43	No	No	0	6	5
498	V:V:V218	V:V:Y272	5.05	No	Yes	0	6	4
499	V:V:V218	V:V:V325	4.81	No	Yes	0	6	7
500	V:V:H219	V:V:T267	4.11	No	No	0	4	5
501	V:V:C269	V:V:H219	5.9	No	No	0	5	4
502	V:V:L327	V:V:V220	7.45	No	No	0	7	7
503	V:V:N222	V:V:T224	4.39	No	No	0	9	8
504	V:V:N222	V:V:V262	5.91	No	Yes	0	9	7
505	V:V:K226	V:V:R331	6.19	No	No	0	8	4
506	V:V:P264	V:V:T227	3.5	No	No	0	5	5
507	V:V:S330	V:V:T227	3.2	No	No	0	6	5
508	V:V:V228	V:V:V262	3.21	No	Yes	0	8	7
509	V:V:V228	V:V:V329	4.81	No	No	0	8	5
510	V:V:K229	V:V:K230	4.31	No	Yes	26	8	7
511	V:V:K229	V:V:S330	4.59	No	No	0	8	6
512	V:V:K230	V:V:K232	5.75	Yes	Yes	0	7	6
513	V:V:E257	V:V:K230	13.5	No	Yes	0	7	7
514	V:V:F268	V:V:I231	3.77	Yes	No	11	4	7
515	V:V:I231	V:V:Y272	4.84	No	Yes	11	7	4
516	V:V:I231	V:V:L327	5.71	No	No	0	7	7
517	V:V:K232	V:V:M255	4.32	Yes	No	0	6	3
518	V:V:K232	V:V:K326	8.62	Yes	No	0	6	7
519	V:V:K232	V:V:V328	4.55	Yes	No	0	6	3
520	V:V:I233	V:V:Y272	9.67	Yes	Yes	0	5	4
521	V:V:I233	V:V:L274	5.71	Yes	No	0	5	5
522	V:V:I233	V:V:V325	6.14	Yes	Yes	0	5	7
523	V:V:R236	V:V:S234	3.95	No	No	5	5	5
524	V:V:K324	V:V:S234	4.59	Yes	No	5	8	5
525	V:V:A254	V:V:V235	3.39	No	No	0	6	6
526	V:V:P276	V:V:V235	7.07	No	No	0	9	6
527	V:V:R236	V:V:Y238	10.29	No	Yes	5	5	3
528	V:V:K324	V:V:R236	7.43	Yes	No	5	8	5
529	V:V:L287	V:V:Q237	5.32	No	Yes	0	6	9
530	V:V:A288	V:V:Q237	4.55	No	Yes	0	9	9
531	V:V:Q237	V:V:V319	4.3	Yes	Yes	2	9	8
532	V:V:Q237	V:V:Y321	13.53	Yes	Yes	2	9	9
533	V:V:Q248	V:V:Y238	4.51	No	Yes	5	5	3
534	V:V:K250	V:V:Y238	7.17	No	Yes	5	6	3
535	V:V:K322	V:V:Y238	13.14	No	Yes	5	5	3
536	V:V:E346	V:V:Y238	3.37	No	Yes	5	8	3
537	V:V:A239	V:V:Y249	4	No	No	0	6	6
538	V:V:D240	V:V:Q248	9.14	No	No	0	6	5
539	V:V:D240	V:V:I318	4.2	No	No	0	6	5
540	V:V:I241	V:V:I317	4.42	No	No	0	7	8
541	V:V:C242	V:V:T246	6.76	No	No	0	5	6
542	V:V:K250	V:V:Q248	6.78	No	No	5	6	5
543	V:V:C251	V:V:Y249	6.72	Yes	No	0	6	6
544	V:V:C251	V:V:P252	3.77	Yes	No	0	6	3
545	V:V:C251	V:V:K284	4.85	Yes	No	0	6	7
546	V:V:C251	V:V:L287	3.17	Yes	No	0	6	6
547	V:V:N281	V:V:V253	4.43	No	No	0	8	8
548	V:V:L300	V:V:V253	4.47	No	No	0	9	8
549	V:V:E257	V:V:M255	4.06	No	No	0	7	3
550	V:V:E256	V:V:Y272	5.61	No	Yes	0	4	4
551	V:V:E256	V:V:L274	7.95	No	No	0	4	5
552	V:V:A258	V:V:Y272	5.34	No	Yes	0	5	4
553	V:V:D260	V:V:F268	10.75	No	Yes	11	5	4
554	V:V:D260	V:V:K270	9.68	No	No	11	5	7
555	V:V:D260	V:V:Y272	3.45	No	Yes	11	5	4
556	V:V:S266	V:V:V262	4.85	No	Yes	0	5	7
557	V:V:F268	V:V:V262	6.55	Yes	Yes	0	4	7
558	V:V:A263	V:V:S266	3.42	No	No	0	3	5
559	V:V:F268	V:V:K270	7.44	Yes	No	11	4	7
560	V:V:F268	V:V:Y272	4.13	Yes	Yes	11	4	4
561	V:V:K270	V:V:Y272	22.69	No	Yes	11	7	4
562	V:V:P276	V:V:T275	3.5	No	No	0	9	4
563	V:V:F277	V:V:N280	15.71	No	No	0	3	4
564	V:V:L278	V:V:R282	7.29	No	No	0	7	5
565	V:V:N280	V:V:N281	9.54	No	No	0	4	8
566	V:V:K284	V:V:N281	6.99	No	No	0	7	8
567	V:V:L289	V:V:T298	5.9	No	No	0	7	8
568	V:V:D290	V:V:K292	4.15	No	No	0	9	5
569	V:V:D290	V:V:N299	8.08	No	No	0	9	8
570	V:V:D290	V:V:S302	5.89	No	No	0	9	9
571	V:V:E296	V:V:K292	6.75	No	No	0	7	5
572	V:V:K292	V:V:T298	10.51	No	No	0	5	8
573	V:V:H353	V:V:N299	8.93	No	No	2	8	8
574	V:V:A301	V:V:V319	5.09	No	Yes	0	9	8
575	V:V:S303	V:V:Y321	3.82	No	Yes	0	8	9
576	V:V:S303	V:V:T350	4.8	No	Yes	0	8	5
577	V:V:I318	V:V:T304	4.56	No	No	0	5	9
578	V:V:T304	V:V:V319	3.17	No	Yes	0	9	8
579	V:V:L305	V:V:M352	7.07	No	No	0	5	7
580	V:V:E313	V:V:N311	7.89	No	No	0	8	4
581	V:V:V319	V:V:Y321	5.05	Yes	Yes	2	8	9
582	V:V:F349	V:V:Y321	9.28	Yes	Yes	2	8	9
583	V:V:L351	V:V:Y321	10.55	No	Yes	2	8	9
584	V:V:E346	V:V:K322	8.1	No	No	5	8	5
585	V:V:K322	V:V:P348	11.71	No	No	0	5	9
586	V:V:L347	V:V:V323	4.47	No	No	0	6	5
587	V:V:A344	V:V:K324	3.21	No	Yes	0	3	8
588	V:V:E346	V:V:K324	8.1	No	Yes	5	8	8
589	V:V:V325	V:V:V345	4.81	Yes	Yes	0	7	6
590	V:V:D342	V:V:K326	19.36	No	No	0	7	7
591	V:V:A344	V:V:K326	4.82	No	No	0	3	7
592	V:V:S340	V:V:V328	3.23	No	No	0	4	3
593	V:V:D342	V:V:V328	4.38	No	No	0	7	3
594	V:V:D337	V:V:R331	4.76	No	No	0	3	4
595	V:V:A339	V:V:R331	4.15	No	No	0	3	4
596	V:V:D337	V:V:G332	3.35	No	No	0	3	4
597	V:V:L334	V:V:L335	4.15	No	No	0	5	6
598	V:V:F349	V:V:L351	3.65	Yes	No	2	8	8
599	V:V:M352	V:V:T350	4.52	No	Yes	0	7	5
600	V:V:K357	V:V:P354	3.35	No	No	0	3	7
601	V:V:K355	V:V:P356	11.71	No	No	7	6	7
602	V:V:P182	V:V:Q181	3.16	No	No	0	8	7
603	R:R:A325	R:R:L76	3.15	No	No	0	6	5
604	R:R:C294	R:R:N330	3.15	No	No	0	9	9
605	R:R:T314	R:R:T69	3.14	No	No	0	1	4
606	V:V:A60	V:V:D143	3.09	No	No	0	8	6
607	V:V:I119	V:V:V37	3.07	No	No	0	5	7
608	V:V:I168	V:V:V146	3.07	No	No	0	8	5
609	R:R:H225	R:R:P226	3.05	No	No	0	2	4
610	R:R:I148	R:R:T122	3.04	No	Yes	0	5	6
611	R:R:I300	R:R:T296	3.04	No	No	0	6	5
612	V:V:A90	V:V:Q85	3.03	No	Yes	0	1	9
613	V:V:A90	V:V:E92	3.02	No	No	0	1	2
614	R:R:F86	R:R:G87	3.01	No	No	0	5	8
615	R:R:M132	R:R:T134	3.01	No	Yes	0	4	5
616	V:V:F61	V:V:G141	3.01	Yes	No	0	9	7
617	V:V:L18	V:V:S13	3	No	Yes	0	5	8
618	V:V:K147	V:V:T56	3	No	Yes	0	5	6
619	V:V:L191	V:V:S193	3	No	No	0	5	8
620	R:R:L261	R:R:V171	2.98	No	No	0	8	8
621	R:R:L234	R:R:V238	2.98	No	No	0	6	5
622	R:R:L337	R:R:V287	2.98	No	No	0	8	8
623	R:R:L337	R:R:V290	2.98	No	No	0	8	7
624	V:V:L18	V:V:V41	2.98	No	No	0	5	4
625	R:R:L76	R:R:T72	2.95	No	No	0	5	4
626	R:R:L277	R:R:T281	2.95	No	No	0	6	6
627	V:V:L68	V:V:T74	2.95	No	No	0	7	5
628	V:V:L306	V:V:T304	2.95	No	No	0	2	9
629	R:R:I300	R:R:I304	2.94	No	No	0	6	5
630	R:R:I304	R:R:I310	2.94	No	Yes	0	5	4
631	V:V:D194	V:V:S193	2.94	No	No	0	6	8
632	V:V:I314	V:V:I318	2.94	No	No	0	4	5
633	R:R:I71	R:R:M74	2.92	No	Yes	0	5	5
634	V:V:N83	V:V:T56	2.92	No	Yes	0	4	6
635	V:V:N223	V:V:T221	2.92	No	No	0	6	5
636	V:V:Q181	V:V:S202	2.89	No	No	0	7	6
637	V:V:P121	V:V:R307	2.88	No	No	0	3	3
638	V:V:P133	V:V:R285	2.88	No	No	0	3	5
639	V:V:P178	V:V:R177	2.88	No	No	0	3	1
640	R:R:I280	R:R:L261	2.85	No	No	0	8	8
641	R:R:I280	V:V:L71	2.85	No	Yes	0	8	8
642	R:R:C237	R:R:F241	2.79	No	No	0	5	4
643	R:R:D179	R:R:K176	2.77	No	No	0	5	4
644	R:R:A177	R:R:R181	2.77	No	Yes	0	6	7
645	V:V:L166	V:V:L22	2.77	Yes	No	0	8	8
646	V:V:L100	V:V:L104	2.77	No	Yes	0	5	9
647	V:V:A151	V:V:F149	2.77	No	Yes	0	5	5
648	V:V:A279	V:V:F277	2.77	No	No	0	4	3
649	R:R:H321	R:R:T317	2.74	Yes	No	0	4	4
650	R:R:E272	R:R:K273	2.7	No	No	0	3	3
651	V:V:E176	V:V:K355	2.7	No	No	0	3	6
652	V:V:A174	V:V:Y209	2.67	No	No	0	8	5
653	R:R:R97	R:R:V96	2.62	No	No	0	5	3
654	R:R:D342	R:R:E343	2.6	No	Yes	0	8	5
655	R:R:?369	R:R:A370	2.59	Yes	No	0	6	7
656	V:V:E152	V:V:E50	2.54	No	No	0	4	3
657	R:R:R260	V:V:N245	2.41	No	No	0	5	7
658	R:R:N276	R:R:R279	2.41	No	No	0	5	7
659	V:V:Q130	V:V:R282	2.34	No	No	0	8	5
660	V:V:E313	V:V:R312	2.33	No	No	0	8	5
661	R:R:R275	R:R:R278	2.13	No	Yes	8	4	5
662	V:V:G332	V:V:G333	2.11	No	No	0	4	7
663	V:V:G332	V:V:G336	2.11	No	No	0	4	3
664	R:R:G87	R:R:P335	2.03	No	No	0	8	9
665	V:V:C140	V:V:G64	1.96	No	No	0	6	9
666	R:R:G215	R:R:S216	1.86	No	No	0	5	1
667	V:V:G16	V:V:S13	1.86	No	Yes	0	4	8
668	R:R:G201	R:R:V204	1.84	No	No	0	6	5
669	R:R:G133	R:R:T134	1.82	No	Yes	0	2	5
670	V:V:G291	V:V:T298	1.82	No	No	0	8	8
671	R:R:A104	R:R:A186	1.79	No	No	0	5	7
672	R:R:G255	R:R:I258	1.76	No	No	0	3	5
673	V:V:P36	V:V:T116	1.75	No	No	0	4	3
674	R:R:L178	V:V:G64	1.71	No	No	0	4	9
675	V:V:G109	V:V:L108	1.71	No	Yes	0	9	7
676	V:V:G286	V:V:L129	1.71	No	No	0	7	7
677	R:R:V175	V:V:A247	1.7	No	No	0	6	6
678	V:V:A148	V:V:V55	1.7	No	Yes	0	4	6
679	R:R:M207	R:R:P203	1.68	No	No	0	5	8
680	R:R:M245	R:R:P246	1.68	No	No	0	5	8
681	V:V:K95	V:V:P96	1.67	No	No	0	1	1
682	R:R:L202	R:R:P203	1.64	No	No	0	4	8
683	V:V:E308	V:V:G309	1.64	No	No	0	3	3
684	R:R:A339	R:R:I109	1.62	No	No	0	6	8
685	V:V:S215	V:V:V271	1.62	No	No	0	3	5
686	R:R:A208	R:R:K143	1.61	No	No	0	5	6
687	R:R:V82	R:R:V83	1.6	No	No	0	6	5
688	R:R:S121	R:R:T122	1.6	No	Yes	0	5	6
689	R:R:T69	R:R:V318	1.59	No	No	0	4	1
690	R:R:T251	R:R:V247	1.59	No	No	0	5	6
691	R:R:T251	R:R:V252	1.59	No	No	0	5	4
692	R:R:T251	R:R:V288	1.59	No	No	0	5	8
693	R:R:T317	R:R:V318	1.59	No	No	0	4	1
694	R:R:C332	R:R:L333	1.59	Yes	No	0	8	6
695	V:V:C242	V:V:L315	1.59	No	No	0	5	5
696	R:R:T220	R:R:T222	1.57	No	No	0	4	4
697	V:V:E35	V:V:P36	1.57	Yes	No	0	6	4
698	V:V:T56	V:V:T58	1.57	Yes	No	0	6	5
699	V:V:E283	V:V:P133	1.57	No	No	0	4	3
700	V:V:E358	V:V:P356	1.57	No	No	0	1	7
701	R:R:A119	R:R:N152	1.56	No	No	0	7	8
702	R:R:A306	R:R:N232	1.56	No	No	0	4	2
703	R:R:I79	R:R:V80	1.54	No	No	0	4	7
704	R:R:I195	R:R:V191	1.54	No	No	0	4	4
705	R:R:I292	R:R:V247	1.54	No	No	0	6	6
706	R:R:I258	R:R:V284	1.54	No	No	0	5	8
707	R:R:I292	R:R:V288	1.54	No	No	0	6	8
708	R:R:I292	R:R:V293	1.54	No	No	0	6	6
709	R:R:M74	R:R:S78	1.53	Yes	No	0	5	4
710	R:R:I308	R:R:T309	1.52	No	No	0	2	2
711	V:V:C242	V:V:E313	1.52	No	No	0	5	8
712	R:R:M67	R:R:T69	1.51	No	No	0	2	4
713	V:V:A151	V:V:E156	1.51	No	No	0	5	6
714	R:R:L285	R:R:V286	1.49	No	No	0	5	6
715	R:R:L337	R:R:V286	1.49	No	No	0	8	6
716	R:R:I140	R:R:I144	1.47	No	No	0	1	5
717	R:R:I144	R:R:I148	1.47	No	No	0	5	5
718	R:R:L285	R:R:T281	1.47	No	No	0	5	6
719	V:V:D240	V:V:S320	1.47	No	No	0	6	8
720	R:R:K143	R:R:M205	1.44	No	No	0	6	5
721	R:R:I195	R:R:L196	1.43	No	No	0	4	4
722	R:R:I258	R:R:L259	1.43	No	No	0	5	2
723	R:R:I303	R:R:L307	1.43	No	No	0	5	5
724	R:R:I308	R:R:L307	1.43	No	No	0	2	5
725	R:R:Q316	R:R:T313	1.42	Yes	No	0	3	3
726	V:V:D259	V:V:K229	1.38	No	No	26	3	8
727	V:V:D259	V:V:K230	1.38	No	Yes	26	3	7
728	R:R:D179	R:R:L178	1.36	No	No	0	5	4
729	R:R:E343	R:R:K346	1.35	Yes	No	0	5	8
730	R:R:A70	R:R:Y130	1.33	No	Yes	0	4	5
731	V:V:H295	V:V:K138	1.31	No	Yes	0	6	7
732	R:R:F315	R:R:T314	1.3	No	No	0	2	1
733	R:R:R184	R:R:T182	1.29	No	No	0	3	7
734	R:R:D274	R:R:R275	1.19	No	No	0	1	4
735	R:R:R275	R:R:R282	1.07	No	No	8	4	5
736	R:R:R278	R:R:R282	1.07	Yes	No	8	5	5
737	R:R:R279	R:R:R282	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	6.96286	7	0	0
2	L:L:?2	9.256	5	1	0
3	L:L:?4	8.81714	7	1	0
4	R:R:M74	4.13	4	0	5
5	R:R:Y77	6.712	5	1	7
6	R:R:Y108	6.165	4	0	7
7	R:R:L112	5.265	4	16	9
8	R:R:D116	7.312	5	16	9
9	R:R:T122	3.16	4	1	6
10	R:R:L123	8.05	4	1	7
11	R:R:Q126	5.13333	6	1	6
12	R:R:Y130	6.79	4	1	5
13	R:R:T134	4.7075	4	0	5
14	R:R:W135	8.71167	6	1	8
15	R:R:F137	9.6675	4	1	6
16	R:R:C142	4.7875	4	1	9
17	R:R:I146	7.2725	4	1	4
18	R:R:F154	7.3	4	0	6
19	R:R:T155	7.015	4	19	7
20	R:R:Y168	5.858	5	0	8
21	R:R:R181	5.364	5	0	7
22	R:R:F223	14.54	4	21	6
23	R:R:F239	6.415	4	15	6
24	R:R:F243	8.7375	4	15	8
25	R:R:Y254	5.488	5	0	9
26	R:R:R278	3.5675	4	8	5
27	R:R:W295	6.5725	4	0	8
28	R:R:H299	7.49	4	15	7
29	R:R:Y301	7.55	4	1	5
30	R:R:K305	5.3875	4	1	3
31	R:R:I310	5.84	4	1	4
32	R:R:Q316	6.9925	4	1	3
33	R:R:W320	5.69833	6	1	4
34	R:R:H321	8.066	5	1	4
35	R:R:Y328	9.32	4	1	7
36	R:R:C332	3.0875	4	0	8
37	R:R:Y338	5.925	4	0	9
38	R:R:E343	3.3775	4	0	5
39	R:R:F345	7.18833	6	17	8
40	R:R:?369	11.5667	6	9	6
41	R:R:?371	11.11	4	3	4
42	R:R:?372	13.97	6	3	7
43	R:R:?373	11.9825	4	3	5
44	R:R:L374	6.66	4	3	5
45	V:V:K11	8.7425	4	9	9
46	V:V:S13	4.04	4	0	8
47	V:V:N15	7.765	4	6	9
48	V:V:Y21	9.865	4	0	8
49	V:V:R25	9.104	5	9	9
50	V:V:D29	10.4225	4	4	8
51	V:V:E35	6.095	4	7	6
52	V:V:Y47	10.2267	6	6	5
53	V:V:L48	4.5	4	6	4
54	V:V:R51	7.185	4	6	7
55	V:V:Y54	8.6575	4	14	4
56	V:V:V55	6.88	4	13	6
57	V:V:T56	3.17	4	0	6
58	V:V:F61	3.90833	6	20	9
59	V:V:Y63	7.064	5	20	8
60	V:V:D69	8.2675	4	0	9
61	V:V:L71	4.4075	4	0	8
62	V:V:L79	4.332	5	0	6
63	V:V:F80	5.108	5	4	4
64	V:V:Q85	4.53	4	14	9
65	V:V:F87	6.33	4	0	5
66	V:V:Q101	6.3825	4	10	9
67	V:V:R103	10.28	4	3	5
68	V:V:L104	5.302	5	0	9
69	V:V:L108	5.542	5	0	7
70	V:V:F115	8.145	4	13	8
71	V:V:F117	6.9825	4	13	7
72	V:V:L123	4.68	4	4	6
73	V:V:P124	4.4225	4	0	8
74	V:V:K138	4.7575	4	23	7
75	V:V:F149	7.5075	4	0	5
76	V:V:N162	7.1525	4	6	8
77	V:V:L166	5.09	4	9	8
78	V:V:K170	9.926	5	4	9
79	V:V:Y173	8.4575	4	7	4
80	V:V:H198	10.2275	4	25	5
81	V:V:L203	7.042	5	2	9
82	V:V:Y208	10.01	6	2	7
83	V:V:H210	11.9775	4	2	9
84	V:V:E212	5.45	4	2	7
85	V:V:K230	6.235	4	26	7
86	V:V:K232	5.81	4	0	6
87	V:V:I233	6.5325	4	0	5
88	V:V:Q237	6.925	4	2	9
89	V:V:Y238	7.696	5	5	3
90	V:V:C251	4.6275	4	0	6
91	V:V:V262	5.13	4	0	7
92	V:V:F268	6.528	5	11	4
93	V:V:Y272	7.5975	8	11	4
94	V:V:V319	4.164	5	2	8
95	V:V:Y321	8.446	5	2	9
96	V:V:K324	5.8325	4	5	8
97	V:V:V325	4.7875	4	0	7
98	V:V:V345	5.5275	4	0	6
99	V:V:F349	5.97	5	2	8
100	V:V:T350	4.9075	4	24	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	18.4027	16.69	Yes	Yes	0	0	0
2	L:L:Y1	R:R:D149	32.6828	3.45	Yes	No	0	0	5
3	L:L:Y1	R:R:M153	28.5312	7.18	Yes	No	0	0	7
4	L:L:Y1	R:R:H299	28.895	7.62	Yes	Yes	0	0	7
5	L:L:?4	R:R:V145	10.7081	5.16	Yes	No	1	0	5
6	L:L:?2	R:R:W320	14.7935	8.11	Yes	Yes	1	0	4
7	R:R:H321	R:R:W320	10.2191	3.17	Yes	Yes	1	4	4
8	R:R:M153	R:R:W295	29.7686	8.14	No	Yes	0	7	8
9	R:R:H299	R:R:W295	35.1885	4.23	Yes	Yes	0	7	8
10	R:R:L112	R:R:M163	18.8885	4.24	Yes	No	0	9	9
11	R:R:M163	R:R:Y108	10.7032	3.59	No	Yes	0	9	7
12	R:R:D166	R:R:Y108	15.318	6.9	No	Yes	0	8	7
13	R:R:D166	R:R:R181	15.4768	10.72	No	Yes	0	8	7
14	R:R:R181	R:R:T105	13.1624	3.88	Yes	No	0	7	8
15	R:R:T105	V:V:D69	12.9107	7.23	No	Yes	0	8	9
16	R:R:T103	V:V:D69	10.0808	5.78	No	Yes	0	7	9
17	R:R:F291	R:R:W295	59.8191	6.01	No	Yes	0	9	8
18	R:R:F291	R:R:I250	59.9858	3.77	No	No	0	9	8
19	R:R:I250	R:R:S164	60.1592	4.64	No	No	0	8	9
20	R:R:S164	R:R:Y254	62.2946	8.9	No	Yes	0	9	9
21	R:R:R167	R:R:Y254	64.5346	6.17	No	Yes	0	9	9
22	R:R:R167	V:V:L71	74.8051	6.07	No	Yes	0	9	8
23	V:V:L71	V:V:V70	75.8482	4.47	Yes	No	0	8	7
24	V:V:F75	V:V:V70	99.7336	6.55	No	No	0	8	7
25	V:V:F75	V:V:Y63	100	5.16	No	Yes	0	8	8
26	V:V:F61	V:V:Y63	58.5458	4.13	Yes	Yes	20	9	8
27	V:V:F61	V:V:I241	29.4967	3.77	Yes	No	0	9	7
28	V:V:I241	V:V:I317	29.1092	4.42	No	No	0	7	8
29	V:V:F61	V:V:L79	56.8572	3.65	Yes	Yes	0	9	6
30	V:V:C59	V:V:L79	92.1611	6.35	No	Yes	0	6	6
31	V:V:C59	V:V:F80	90.2621	4.19	No	Yes	0	6	4
32	V:V:F80	V:V:L57	90.6963	3.65	Yes	No	0	4	6
33	V:V:F117	V:V:L57	90.5923	13.4	Yes	No	0	7	6
34	V:V:F117	V:V:V55	45.1917	5.24	Yes	Yes	13	7	6
35	V:V:S86	V:V:V55	44.9107	4.85	No	Yes	13	5	6
36	V:V:S86	V:V:V41	89.5044	3.23	No	No	0	5	4
37	V:V:L18	V:V:V41	89.187	2.98	No	No	0	5	4
38	V:V:L18	V:V:S13	88.8693	3	No	Yes	0	5	8
39	V:V:K77	V:V:Y63	41.707	5.97	No	Yes	0	8	8
40	V:V:K77	V:V:L79	41.7259	4.23	No	Yes	0	8	6
41	V:V:F115	V:V:F117	45.1917	5.36	Yes	Yes	13	8	7
42	V:V:F115	V:V:S86	44.9107	3.96	Yes	No	13	8	5
43	V:V:N15	V:V:S13	85.4429	5.96	Yes	Yes	0	9	8
44	V:V:N15	V:V:Y47	80.1772	5.81	Yes	Yes	6	9	5
45	V:V:L48	V:V:Y47	77.0656	3.52	Yes	Yes	6	4	5
46	V:V:F87	V:V:L48	76.0282	3.65	Yes	Yes	0	5	4
47	V:V:F87	V:V:P88	74.4164	4.33	Yes	No	0	5	9
48	V:V:P88	V:V:R52	36.5065	5.76	No	No	14	9	7
49	V:V:R52	V:V:Y54	36.1626	11.32	No	Yes	14	7	4
50	V:V:F149	V:V:Y54	70.9614	8.25	Yes	Yes	0	5	4
51	V:V:F149	V:V:T56	66.7371	5.19	Yes	Yes	0	5	6
52	V:V:K147	V:V:T56	57.5555	3	No	Yes	0	5	6
53	V:V:K147	V:V:R165	56.1379	13.61	No	No	0	5	5
54	R:R:?366	V:V:R165	54.0096	7.23	No	No	0	6	5
55	V:V:P88	V:V:Q85	37.5805	4.74	No	Yes	14	9	9
56	V:V:Q85	V:V:Y54	36.2046	4.51	Yes	Yes	14	9	4
57	R:R:?366	V:V:K11	53.2995	6	No	Yes	0	6	9
58	R:R:?369	V:V:K11	45.4064	17.37	Yes	Yes	9	6	9
59	R:R:?369	R:R:A370	38.2915	2.59	Yes	No	0	6	7
60	R:R:?371	R:R:A370	37.5762	4.02	Yes	No	0	4	7
61	R:R:?371	R:R:?372	17.3461	17.02	Yes	Yes	3	4	7
62	R:R:?371	V:V:R7	10.1191	18.6	Yes	No	3	4	5
63	R:R:?373	R:R:L374	17.3632	4.71	Yes	Yes	3	5	5
64	R:R:L374	V:V:R103	14.4883	13.36	Yes	Yes	3	5	5
65	V:V:I119	V:V:P120	10.4399	3.39	No	No	0	5	6
66	V:V:I119	V:V:V37	10.5138	3.07	No	No	0	5	7
67	V:V:F27	V:V:V37	10.0384	15.73	No	No	0	7	7
68	V:V:I317	V:V:V127	27.9404	7.68	No	No	0	8	8
69	V:V:V127	V:V:V319	27.8103	3.21	No	Yes	0	8	8
70	V:V:R103	V:V:R99	11.594	7.46	Yes	No	0	5	4
71	V:V:E102	V:V:R99	10.1457	6.98	No	No	0	6	4
72	V:V:V319	V:V:Y321	16.6709	5.05	Yes	Yes	2	8	9
73	V:V:F349	V:V:Y321	14.8567	9.28	Yes	Yes	2	8	9
74	L:L:?4	R:R:D149	24.8774	7.05	Yes	No	0	0	5
75	R:R:R167	R:R:Y338	10.6878	9.26	No	Yes	0	9	9
76	R:R:R181	V:V:V70	24.3305	3.92	Yes	No	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:D149	3.45	0	Yes	No	0	5	0	1
L:L:Y1	R:R:Y150	4.96	0	Yes	No	0	4	0	1
L:L:Y1	R:R:M153	7.18	0	Yes	No	0	7	0	1
L:L:Y1	R:R:V238	5.05	0	Yes	No	0	5	0	1
L:L:Y1	R:R:H299	7.62	0	Yes	Yes	0	7	0	1
L:L:Y1	R:R:V302	3.79	0	Yes	No	0	5	0	1
L:L:?2	R:R:I298	5.81	1	Yes	No	0	6	0	1
L:L:?2	R:R:W320	8.11	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:I324	8.71	1	Yes	No	0	5	0	1
L:L:G3	R:R:Q126	3.29	1	No	Yes	0	6	0	1
L:L:?4	R:R:Q126	4.61	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N129	3.56	1	Yes	No	0	4	0	1
L:L:?4	R:R:V145	5.16	1	Yes	No	0	5	0	1
L:L:?4	R:R:I146	16.05	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:D149	7.05	1	Yes	No	0	5	0	1
L:L:?5	R:R:T220	3.97	0	No	No	0	4	0	1
R:R:L123	R:R:Y77	3.52	1	Yes	Yes	7	7	2	2
R:R:Q126	R:R:Y77	4.51	1	Yes	Yes	6	7	1	2
R:R:H321	R:R:Y77	11.98	1	Yes	Yes	4	7	2	2
R:R:I324	R:R:Y77	8.46	1	No	Yes	5	7	1	2
R:R:Q126	R:R:T122	4.25	1	Yes	Yes	6	6	1	2
R:R:T122	R:R:Y328	3.75	1	Yes	Yes	6	7	2	2
R:R:L123	R:R:Q126	3.99	1	Yes	Yes	7	6	2	1
R:R:L123	R:R:Y328	19.93	1	Yes	Yes	7	7	2	2
R:R:F125	R:R:W135	4.01	1	No	Yes	6	8	2	2
R:R:F125	R:R:V145	13.11	1	No	No	6	5	2	1
R:R:Q126	R:R:Y328	10.15	1	Yes	Yes	6	7	1	2
R:R:N129	R:R:W135	9.04	0	No	Yes	4	8	1	2
R:R:C142	R:R:W135	5.22	1	Yes	Yes	9	8	2	2
R:R:V145	R:R:W135	4.9	1	No	Yes	5	8	1	2
R:R:C219	R:R:W135	13.06	1	No	Yes	9	8	2	2
R:R:C142	R:R:I146	3.27	1	Yes	Yes	9	4	2	1
R:R:C142	R:R:C219	7.28	1	Yes	No	9	9	2	2
R:R:A208	R:R:I146	6.5	0	No	Yes	5	4	2	1
R:R:C219	R:R:I146	3.27	1	No	Yes	9	4	2	1
R:R:D149	R:R:Y328	3.45	0	No	Yes	5	7	1	2
R:R:V204	R:R:Y150	11.36	0	No	No	5	4	2	1
R:R:L221	R:R:Y150	3.52	0	No	No	4	4	2	1
R:R:I157	R:R:M153	4.37	0	No	No	7	7	2	1
R:R:M153	R:R:W295	8.14	0	No	Yes	7	8	1	2
R:R:F154	R:R:V238	7.87	0	Yes	No	6	5	2	1
R:R:K211	R:R:T220	7.51	0	No	No	1	4	2	1
R:R:K235	R:R:V302	6.07	0	No	No	4	5	2	1
R:R:F239	R:R:F243	8.57	15	Yes	Yes	6	8	2	2
R:R:F239	R:R:H299	4.53	15	Yes	Yes	6	7	2	1
R:R:F243	R:R:H299	13.58	15	Yes	Yes	8	7	2	1
R:R:H299	R:R:W295	4.23	15	Yes	Yes	7	8	1	2
R:R:I298	R:R:W320	3.52	1	No	Yes	6	4	1	1
R:R:C323	R:R:I298	3.27	0	No	No	6	6	2	1
R:R:K305	R:R:Y301	5.97	1	Yes	Yes	3	5	2	2
R:R:W320	R:R:Y301	7.72	1	Yes	Yes	4	5	1	2
R:R:K305	R:R:W320	5.8	1	Yes	Yes	3	4	2	1
R:R:H321	R:R:W320	3.17	1	Yes	Yes	4	4	2	1
R:R:I324	R:R:W320	5.87	1	No	Yes	5	4	1	1
R:R:L234	R:R:V238	2.98	0	No	No	6	5	2	1
R:R:T220	R:R:T222	1.57	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9WSV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	630
Number of Links	737
Number of Hubs	100
Number of Links mediated by Hubs	369
Number of Communities	26
Number of Nodes involved in Communities	145
Number of Links involved in Communities	192

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	998659
Length Of Smallest Path	3
Average Path Length	32.4104
Length of Longest Path	60
Minimum Path Strength	1.07
Average Path Strength	6.05745
Maximum Path Strength	21.615
Minimum Path Correlation	0.7
Average Path Correlation	0.974462
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	40.7604
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.775
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Arrestin/Vps26-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Arrestin/Vps26-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	MEA
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951135
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ETA
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ETA
Name	Ethanolamine
Synonyms	Ethanolamine
Identifier
Formula	C2 H7 N O
Molecular Weight	61.083
SMILES
PubChem	700
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


Code	SEP
PDB Residues	R:R:?366 R:R:?371 R:R:?372 R:R:?373
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES
PubChem	57689797
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	TPO
PDB Residues	R:R:?368 R:R:?369
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>9WSV_nogp_Chain_R P S M T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F C V N V I E ?C ??A ???L A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P17870
Sequence	>9WSV_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V E P V D G V V L V D P E Y L K E R R V Y V T L T C A F R Y G R E D L D V L G L T F R K D L F V A N V Q S F P P A P E D K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P C S V T L Q P G P E D T G K A C G V D Y E V K A F C A E N L E E K I H K R N S V R L V I K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I C L F N T A Q Y K C P V A M E E A D D T V A P S S T F C K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G G L L G D L A S S D V A V E L P F T L M H P K P K E E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

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