psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A567	R:R:Q571	3.03	No	No	0	3	6
2	R:R:P569	R:R:S568	3.56	Yes	No	0	4	8
3	R:R:Q571	R:R:S568	4.33	No	No	0	6	8
4	R:R:I581	R:R:P569	5.08	No	Yes	0	5	4
5	R:R:P569	R:R:V584	3.53	Yes	No	0	4	5
6	R:R:P569	R:R:V729	3.53	Yes	Yes	0	4	7
7	R:R:R574	R:R:V570	6.54	No	No	0	6	4
8	R:R:Q571	R:R:W575	13.14	No	No	0	6	5
9	R:R:W575	R:R:Y572	6.75	No	Yes	0	5	6
10	R:R:D577	R:R:Y572	3.45	Yes	Yes	1	7	6
11	R:R:P580	R:R:Y572	5.56	Yes	Yes	1	7	6
12	R:R:E728	R:R:Y572	6.73	No	Yes	0	5	6
13	R:R:V729	R:R:Y572	15.14	Yes	Yes	1	7	6
14	R:R:I581	R:R:L573	4.28	No	No	0	5	7
15	R:R:D577	R:R:P578	4.83	Yes	No	0	7	3
16	R:R:A579	R:R:D577	4.63	No	Yes	0	6	7
17	R:R:D577	R:R:P580	6.44	Yes	Yes	1	7	7
18	R:R:A579	R:R:I800	3.25	No	No	0	6	8
19	R:R:P580	R:R:V729	3.53	Yes	Yes	1	7	7
20	R:R:P580	R:R:Y730	5.56	Yes	Yes	1	7	6
21	R:R:L589	R:R:V585	2.98	No	No	0	3	3
22	R:R:F586	R:R:Y629	3.09	No	Yes	4	3	8
23	R:R:F586	R:R:S807	6.61	No	No	4	3	8
24	R:R:F586	R:R:T811	6.49	No	No	4	3	6
25	R:R:A587	R:R:T632	5.03	No	No	0	7	7
26	R:R:A587	R:R:F633	4.16	No	Yes	0	7	6
27	R:R:G590	R:R:Y629	10.14	No	Yes	0	6	8
28	R:R:L591	R:R:L630	5.54	No	No	0	6	6
29	R:R:F633	R:R:L591	3.65	Yes	No	0	6	6
30	R:R:L622	R:R:T594	2.95	No	No	0	9	7
31	R:R:I625	R:R:T594	3.04	Yes	No	0	8	7
32	R:R:L595	R:R:V599	2.98	No	No	0	3	3
33	R:R:F596	R:R:V600	3.93	No	Yes	0	2	5
34	R:R:F601	R:R:V597	3.93	Yes	Yes	2	8	6
35	R:R:L814	R:R:V597	4.47	No	Yes	2	8	6
36	R:R:F818	R:R:V597	3.93	Yes	Yes	2	8	6
37	R:R:V597	R:R:V822	4.81	Yes	Yes	2	6	7
38	R:R:I602	R:R:T598	3.04	No	No	0	4	4
39	R:R:L622	R:R:T598	8.84	No	No	0	9	4
40	R:R:I603	R:R:V599	3.07	No	No	0	3	3
41	R:R:V600	R:R:V822	6.41	Yes	Yes	2	5	7
42	R:R:I825	R:R:V600	3.07	No	Yes	0	8	5
43	R:R:L826	R:R:V600	5.96	No	Yes	2	6	5
44	R:R:F601	R:R:V610	3.93	Yes	No	0	8	9
45	R:R:F601	R:R:F818	6.43	Yes	Yes	2	8	8
46	R:R:F601	R:R:K821	4.96	Yes	Yes	2	8	9
47	R:R:F601	R:R:V822	3.93	Yes	Yes	2	8	7
48	R:R:I602	R:R:Y619	4.84	No	No	0	4	5
49	R:R:I603	R:R:Y604	7.25	No	Yes	0	3	5
50	R:R:T607	R:R:Y604	6.24	Yes	Yes	0	9	5
51	R:R:I825	R:R:Y604	9.67	No	Yes	0	8	5
52	R:R:L826	R:R:Y604	3.52	No	Yes	0	6	5
53	R:R:D606	R:R:R605	5.96	No	No	0	4	5
54	R:R:R605	R:R:R615	4.26	No	No	0	5	8
55	R:R:D606	R:R:K611	8.3	No	No	0	4	7
56	R:R:T607	R:R:V609	3.17	Yes	Yes	2	9	6
57	R:R:T607	R:R:V610	3.17	Yes	No	0	9	9
58	R:R:N832	R:R:T607	8.77	No	Yes	2	9	9
59	R:R:N832	R:R:P608	6.52	No	No	0	9	7
60	R:R:F768	R:R:V609	6.55	No	Yes	0	9	6
61	R:R:K821	R:R:V609	3.04	Yes	Yes	2	9	6
62	R:R:I825	R:R:V609	3.07	No	Yes	0	8	6
63	R:R:N832	R:R:V609	8.87	No	Yes	2	9	6
64	R:R:K611	R:R:R615	12.38	No	No	0	7	8
65	R:R:N767	R:R:S612	5.96	No	No	0	8	9
66	R:R:K665	R:R:S613	4.59	No	Yes	2	9	9
67	R:R:N767	R:R:S613	2.98	No	Yes	2	8	9
68	R:R:E770	R:R:S613	8.62	Yes	Yes	2	9	9
69	R:R:K821	R:R:S613	3.06	Yes	Yes	2	9	9
70	R:R:L617	R:R:S614	7.51	Yes	No	5	8	9
71	R:R:Q693	R:R:S614	5.78	Yes	No	5	8	9
72	R:R:E616	R:R:L694	5.3	No	No	0	7	5
73	R:R:A661	R:R:L617	4.73	No	Yes	0	7	8
74	R:R:L617	R:R:T664	2.95	Yes	No	5	8	6
75	R:R:L617	R:R:Q693	5.32	Yes	Yes	5	8	8
76	R:R:A661	R:R:I620	3.25	No	No	0	7	6
77	R:R:I621	R:R:I625	2.94	Yes	Yes	0	8	8
78	R:R:I621	R:R:S658	3.1	Yes	No	0	8	6
79	R:R:A661	R:R:I621	3.25	No	Yes	0	7	8
80	R:R:F818	R:R:I621	3.77	Yes	Yes	0	8	8
81	R:R:F818	R:R:L622	9.74	Yes	No	0	8	9
82	R:R:G624	R:R:M657	3.49	No	No	0	8	5
83	R:R:A810	R:R:I625	3.25	No	Yes	0	7	8
84	R:R:I625	R:R:L814	7.14	Yes	No	0	8	8
85	R:R:C626	R:R:L630	3.17	No	No	0	4	6
86	R:R:G650	R:R:L627	5.13	No	No	0	5	5
87	R:R:L627	R:R:S654	4.5	No	No	0	5	7
88	R:R:L627	R:R:M657	4.24	No	No	0	5	5
89	R:R:G628	R:R:S654	3.71	No	No	0	6	7
90	R:R:S807	R:R:Y629	5.09	No	Yes	4	8	8
91	R:R:A810	R:R:Y629	5.34	No	Yes	0	7	8
92	R:R:T811	R:R:Y629	7.49	No	Yes	4	6	8
93	R:R:C631	R:R:I651	3.27	No	No	0	7	7
94	R:R:I636	R:R:T632	3.04	No	No	1	8	7
95	R:R:C803	R:R:T632	5.07	No	No	1	7	7
96	R:R:?634	R:R:F633	3.12	Yes	Yes	0	5	6
97	R:R:?634	R:R:L635	3.54	Yes	No	1	5	7
98	R:R:?634	R:R:A637	4.03	Yes	No	1	5	8
99	R:R:?634	R:R:Y643	7	Yes	Yes	1	5	7
100	R:R:?634	R:R:L646	3.54	Yes	No	0	5	5
101	R:R:?634	R:R:Q647	9.08	Yes	Yes	1	5	8
102	R:R:L635	R:R:Q647	10.65	No	Yes	1	7	8
103	R:R:C803	R:R:L635	6.35	No	No	1	7	7
104	R:R:I636	R:R:V729	3.07	No	Yes	1	8	7
105	R:R:C803	R:R:I636	3.27	No	No	1	7	8
106	R:R:A637	R:R:Y643	5.34	No	Yes	1	8	7
107	R:R:I642	R:R:K640	4.36	No	No	1	4	5
108	R:R:K640	R:R:Y643	4.78	No	Yes	1	5	7
109	R:R:Q641	R:R:Y645	9.02	No	No	0	3	4
110	R:R:D718	R:R:Q641	5.22	No	No	0	3	3
111	R:R:I642	R:R:Y643	3.63	No	Yes	1	4	7
112	R:R:C644	R:R:L731	4.76	No	No	0	9	6
113	R:R:C644	R:R:C733	7.28	No	No	0	9	9
114	R:R:F712	R:R:Y645	13.41	Yes	No	6	6	4
115	R:R:P717	R:R:Y645	22.25	Yes	No	6	8	4
116	R:R:L731	R:R:Q647	3.99	No	Yes	0	6	8
117	R:R:C733	R:R:Q647	6.1	No	Yes	0	9	8
118	R:R:F712	R:R:R648	13.9	Yes	No	6	6	8
119	R:R:P717	R:R:R648	12.97	Yes	No	6	8	8
120	R:R:R648	R:R:T735	9.06	No	No	0	8	6
121	R:R:F712	R:R:I649	5.02	Yes	No	0	6	5
122	R:R:I651	R:R:M802	2.92	No	Yes	0	7	8
123	R:R:G652	R:R:Q704	3.29	No	Yes	0	5	9
124	R:R:I701	R:R:L653	2.85	No	No	0	7	6
125	R:R:L653	R:R:L705	4.15	No	No	0	6	4
126	R:R:P655	R:R:S654	3.56	Yes	No	0	8	7
127	R:R:P655	R:R:Y659	4.17	Yes	Yes	3	8	7
128	R:R:N747	R:R:P655	13.03	No	Yes	3	7	8
129	R:R:P655	R:R:W785	5.4	Yes	Yes	3	8	8
130	R:R:A656	R:R:Q704	3.03	No	Yes	0	8	9
131	R:R:I701	R:R:M657	5.83	No	No	0	7	5
132	R:R:S658	R:R:Y659	3.82	No	Yes	0	6	7
133	R:R:I751	R:R:Y659	8.46	Yes	Yes	3	8	7
134	R:R:T781	R:R:Y659	7.49	Yes	Yes	3	9	7
135	R:R:S809	R:R:Y659	3.82	No	Yes	0	9	7
136	R:R:L700	R:R:S660	6.01	No	Yes	0	4	9
137	R:R:I701	R:R:S660	3.1	No	Yes	0	7	9
138	R:R:L750	R:R:S660	3	No	Yes	0	9	9
139	R:R:C754	R:R:L662	4.76	No	No	0	8	6
140	R:R:L662	R:R:M817	4.24	No	No	0	6	8
141	R:R:T666	R:R:V663	3.17	No	No	0	9	7
142	R:R:C754	R:R:V663	3.42	No	No	0	8	7
143	R:R:Q693	R:R:T664	4.25	Yes	No	5	8	6
144	R:R:I696	R:R:T664	3.04	No	No	0	7	6
145	R:R:E770	R:R:K665	5.4	Yes	No	2	9	9
146	R:R:T666	R:R:Y757	4.99	No	No	0	9	7
147	R:R:R671	R:R:Y667	15.43	Yes	No	0	7	5
148	R:R:Y667	R:R:Y757	8.94	No	No	0	5	7
149	R:R:M688	R:R:R668	9.93	No	No	0	5	8
150	R:R:Q693	R:R:R668	8.18	Yes	No	0	8	8
151	R:R:M688	R:R:R671	6.2	No	Yes	0	5	7
152	R:R:I672	R:R:M675	2.92	No	No	0	9	7
153	R:R:I672	R:R:M688	2.92	No	No	0	9	5
154	R:R:L673	R:R:S676	4.5	No	No	0	9	7
155	R:R:K677	R:R:L673	5.64	No	No	0	5	9
156	R:R:?691	R:R:S689	3.84	Yes	No	0	3	7
157	R:R:A692	R:R:S689	3.42	No	No	0	7	7
158	R:R:?691	R:R:L694	3.54	Yes	No	0	3	5
159	R:R:?691	R:R:V695	3.81	Yes	No	0	3	4
160	R:R:I699	R:R:V695	3.07	No	No	0	3	4
161	R:R:C702	R:R:F698	8.38	No	No	0	3	3
162	R:R:L700	R:R:Y746	3.52	No	Yes	0	4	8
163	R:R:I703	R:R:Y746	12.09	No	Yes	0	4	8
164	R:R:I708	R:R:Q704	4.12	No	Yes	0	6	9
165	R:R:P743	R:R:Q704	6.32	No	Yes	0	7	9
166	R:R:Q704	R:R:Y746	7.89	Yes	Yes	0	9	8
167	R:R:N747	R:R:Q704	5.28	No	Yes	0	7	9
168	R:R:L705	R:R:V709	2.98	No	No	0	4	3
169	R:R:F712	R:R:I708	5.02	Yes	No	0	6	6
170	R:R:F712	R:R:P717	5.78	Yes	Yes	6	6	8
171	R:R:E715	R:R:T736	5.64	No	No	0	5	8
172	R:R:E715	R:R:L738	3.98	No	No	0	5	2
173	R:R:D718	R:R:N734	5.39	No	No	0	3	5
174	R:R:I719	R:R:L731	4.28	Yes	No	0	6	6
175	R:R:I719	R:R:I732	2.94	Yes	No	8	6	6
176	R:R:E728	R:R:Y730	10.1	No	Yes	0	5	6
177	R:R:V729	R:R:Y730	7.57	Yes	Yes	1	7	6
178	R:R:I799	R:R:Y730	6.04	No	Yes	0	7	6
179	R:R:I800	R:R:Y730	6.04	No	Yes	0	8	6
180	R:R:F793	R:R:N737	6.04	Yes	No	0	6	3
181	R:R:K798	R:R:N737	4.2	No	No	0	6	3
182	R:R:L744	R:R:W785	7.97	No	Yes	0	8	8
183	R:R:F788	R:R:L744	7.31	Yes	No	0	9	8
184	R:R:L750	R:R:Y746	10.55	No	Yes	0	9	8
185	R:R:N747	R:R:W785	5.65	No	Yes	3	7	8
186	R:R:G748	R:R:I751	5.29	No	Yes	0	5	8
187	R:R:I751	R:R:M778	4.37	Yes	Yes	3	8	9
188	R:R:I751	R:R:T781	4.56	Yes	Yes	3	8	9
189	R:R:I751	R:R:W785	10.57	Yes	Yes	3	8	8
190	R:R:C754	R:R:M778	8.1	No	Yes	0	8	9
191	R:R:M778	R:R:T755	7.53	Yes	No	0	9	8
192	R:R:C782	R:R:T755	5.07	No	No	0	6	8
193	R:R:F756	R:R:K760	3.72	No	No	0	4	7
194	R:R:F759	R:R:R762	19.24	No	No	0	8	9
195	R:R:F759	R:R:Y779	5.16	No	No	0	8	9
196	R:R:T761	R:R:V764	3.17	No	Yes	0	8	8
197	R:R:N763	R:R:R762	8.44	No	No	0	7	9
198	R:R:P765	R:R:V764	3.53	No	Yes	0	9	8
199	R:R:N769	R:R:P765	4.89	No	No	0	9	9
200	R:R:E770	R:R:N767	9.2	Yes	No	2	9	8
201	R:R:K772	R:R:N769	5.6	No	No	0	9	9
202	R:R:E770	R:R:I774	5.47	Yes	No	0	9	9
203	R:R:E770	R:R:K821	6.75	Yes	Yes	2	9	9
204	R:R:K772	R:R:Y773	11.94	No	No	0	9	5
205	R:R:P820	R:R:Y773	5.56	No	No	0	9	5
206	R:R:F776	R:R:T780	3.89	No	No	0	8	8
207	R:R:T777	R:R:T780	3.14	Yes	No	0	9	8
208	R:R:C816	R:R:T777	6.76	No	Yes	0	5	9
209	R:R:M817	R:R:T777	6.02	No	Yes	0	8	9
210	R:R:M778	R:R:T781	4.52	Yes	Yes	3	9	9
211	R:R:F788	R:R:Y792	13.41	Yes	Yes	7	9	8
212	R:R:F788	R:R:M802	3.73	Yes	Yes	7	9	8
213	R:R:F788	R:R:S805	6.61	Yes	No	0	9	8
214	R:R:P790	R:R:V789	3.53	No	No	0	9	7
215	R:R:F793	R:R:Y792	6.19	Yes	Yes	0	6	8
216	R:R:K798	R:R:Y792	16.72	No	Yes	0	6	8
217	R:R:T801	R:R:Y792	4.99	No	Yes	0	8	8
218	R:R:M802	R:R:Y792	5.99	Yes	Yes	7	8	8
219	R:R:S795	R:R:T801	4.8	No	No	0	8	8
220	R:R:F804	R:R:I800	6.28	No	No	0	7	8
221	R:R:M802	R:R:V806	3.04	Yes	No	0	8	8
222	R:R:F818	R:R:L814	3.65	Yes	No	2	8	8
223	R:R:G815	R:R:V819	3.68	No	No	0	2	4
224	R:R:F818	R:R:M817	6.22	Yes	No	0	8	8
225	R:R:P820	R:R:V819	3.53	No	No	0	9	4
226	R:R:L826	R:R:V822	2.98	No	Yes	2	6	7
227	R:R:A827	R:R:Y823	4	No	No	0	4	8
228	R:R:A827	R:R:K828	3.21	No	No	0	4	6
229	R:R:K828	R:R:R831	4.95	No	No	0	6	5
230	R:R:L711	R:R:M714	2.83	No	No	0	7	3
231	R:R:C588	R:R:F633	2.79	No	Yes	0	3	6
232	R:R:C618	R:R:F818	2.79	No	Yes	0	9	8
233	R:R:A583	R:R:F804	2.77	No	No	0	8	7
234	R:R:I707	R:R:Q704	2.74	No	Yes	0	7	9
235	R:R:?691	R:R:A690	2.69	Yes	No	0	3	6
236	R:R:A753	R:R:Y757	2.67	No	No	0	4	7
237	R:R:A775	R:R:Y779	2.67	No	No	0	9	9
238	R:R:F793	R:R:V741	2.62	Yes	No	0	6	6
239	R:R:F793	R:R:V789	2.62	Yes	No	0	6	7
240	R:R:S795	R:R:Y797	2.54	No	No	0	8	5
241	R:R:V740	R:R:Y792	2.52	No	Yes	0	8	8
242	R:R:I602	R:R:R605	2.51	No	No	0	4	5
243	R:R:T755	R:R:Y779	2.5	No	No	0	8	9
244	R:R:F759	R:R:K760	2.48	No	No	0	8	7
245	R:R:I784	R:R:W785	2.35	No	Yes	0	8	8
246	R:R:L591	R:R:Y629	2.34	No	Yes	0	6	8
247	R:R:N796	R:R:Y797	2.33	No	No	0	5	5
248	R:R:A593	R:R:G590	1.95	No	No	0	4	6
249	R:R:P716	R:R:P717	1.95	No	Yes	0	8	8
250	R:R:A742	R:R:P743	1.87	No	No	0	4	7
251	R:R:G706	R:R:V709	1.84	No	No	0	4	3
252	R:R:A758	R:R:A775	1.79	No	No	0	9	9
253	R:R:A697	R:R:S660	1.71	No	Yes	0	7	9
254	R:R:G739	R:R:L711	1.71	No	No	0	7	7
255	R:R:G739	R:R:L738	1.71	No	No	0	7	2
256	R:R:G745	R:R:L744	1.71	No	No	0	5	8
257	R:R:A766	R:R:V764	1.7	No	Yes	0	7	8
258	R:R:A771	R:R:V764	1.7	No	Yes	0	9	8
259	R:R:I719	R:R:P639	1.69	Yes	No	0	6	9
260	R:R:A669	R:R:T761	1.68	No	No	0	9	8
261	R:R:A670	R:R:T761	1.68	No	No	0	6	8
262	R:R:A813	R:R:T777	1.68	No	Yes	0	7	9
263	R:R:K638	R:R:P639	1.67	No	No	0	5	9
264	R:R:K828	R:R:P829	1.67	No	No	0	6	8
265	R:R:L711	R:R:P743	1.64	No	No	0	7	7
266	R:R:S568	R:R:V570	1.62	No	No	0	8	4
267	R:R:A787	R:R:I791	1.62	No	No	0	7	7
268	R:R:T781	R:R:V812	1.59	Yes	No	0	9	7
269	R:R:I713	R:R:V709	1.54	No	No	0	3	3
270	R:R:L673	R:R:V764	1.49	No	Yes	0	9	8
271	R:R:I732	R:R:M720	1.46	No	No	0	6	4
272	R:R:I620	R:R:L694	1.43	No	No	0	6	5
273	R:R:I784	R:R:L808	1.43	No	No	0	8	6
274	R:R:A582	R:R:F804	1.39	No	No	0	3	7
275	R:R:A670	R:R:R671	1.38	No	Yes	0	6	7
276	R:R:A674	R:R:R671	1.38	No	Yes	0	5	7
277	R:R:H721	R:R:I719	1.33	No	Yes	8	2	6
278	R:R:H721	R:R:I732	1.33	No	No	8	2	6
279	R:R:F698	R:R:I699	1.26	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P569	3.925	4	0	4
2	R:R:Y572	7.526	5	1	6
3	R:R:D577	4.8375	4	1	7
4	R:R:P580	5.2725	4	1	7
5	R:R:V597	4.285	4	2	6
6	R:R:V600	4.8425	4	2	5
7	R:R:F601	4.636	5	2	8
8	R:R:Y604	6.67	4	0	5
9	R:R:T607	5.3375	4	2	9
10	R:R:V609	4.94	5	2	6
11	R:R:S613	4.8125	4	2	9
12	R:R:L617	5.1275	4	5	8
13	R:R:I621	3.265	4	0	8
14	R:R:I625	4.0925	4	0	8
15	R:R:Y629	5.58167	6	4	8
16	R:R:F633	3.43	4	0	6
17	R:R:?634	5.05167	6	1	5
18	R:R:Y643	5.1875	4	1	7
19	R:R:Q647	7.455	4	1	8
20	R:R:P655	6.54	4	3	8
21	R:R:Y659	5.552	5	3	7
22	R:R:S660	3.455	4	0	9
23	R:R:R671	6.0975	4	0	7
24	R:R:?691	3.47	4	0	3
25	R:R:Q693	5.8825	4	5	8
26	R:R:Q704	4.66714	7	0	9
27	R:R:F712	8.626	5	6	6
28	R:R:P717	10.7375	4	6	8
29	R:R:I719	2.56	4	8	6
30	R:R:V729	6.568	5	1	7
31	R:R:Y730	7.062	5	1	6
32	R:R:Y746	8.5125	4	0	8
33	R:R:I751	6.65	5	3	8
34	R:R:V764	2.318	5	0	8
35	R:R:E770	7.088	5	2	9
36	R:R:T777	4.4	4	0	9
37	R:R:M778	6.13	4	3	9
38	R:R:T781	4.54	4	3	9
39	R:R:W785	6.388	5	3	8
40	R:R:F788	7.765	4	7	9
41	R:R:Y792	8.30333	6	7	8
42	R:R:F793	4.3675	4	0	6
43	R:R:M802	3.92	4	7	8
44	R:R:F818	5.21857	7	2	8
45	R:R:K821	4.4525	4	2	9
46	R:R:V822	4.5325	4	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P569	R:R:V729	16.4206	3.53	Yes	Yes	0	4	7
2	R:R:V729	R:R:Y730	14.2403	7.57	Yes	Yes	1	7	6
3	R:R:V729	R:R:Y572	14.1949	15.14	Yes	Yes	1	7	6
4	R:R:I636	R:R:V729	51.8567	3.07	No	Yes	1	8	7
5	R:R:I636	R:R:T632	50.0965	3.04	No	No	1	8	7
6	R:R:A587	R:R:T632	53.1967	5.03	No	No	0	7	7
7	R:R:A587	R:R:F633	54.7013	4.16	No	Yes	0	7	6
8	R:R:F633	R:R:L591	87.6561	3.65	Yes	No	0	6	6
9	R:R:L591	R:R:Y629	91.4944	2.34	No	Yes	0	6	8
10	R:R:A810	R:R:Y629	98.819	5.34	No	Yes	0	7	8
11	R:R:A810	R:R:I625	100	3.25	No	Yes	0	7	8
12	R:R:I625	R:R:L814	24.3811	7.14	Yes	No	0	8	8
13	R:R:L814	R:R:V597	11.0379	4.47	No	Yes	2	8	6
14	R:R:V597	R:R:V822	12.6164	4.81	Yes	Yes	2	6	7
15	R:R:L826	R:R:V822	12.1962	2.98	No	Yes	2	6	7
16	R:R:I603	R:R:Y604	10.913	7.25	No	Yes	0	3	5
17	R:R:I621	R:R:I625	75.6473	2.94	Yes	Yes	0	8	8
18	R:R:F818	R:R:I621	59.4481	3.77	Yes	Yes	0	8	8
19	R:R:F601	R:R:F818	47.5414	6.43	Yes	Yes	2	8	8
20	R:R:F818	R:R:L814	13.4283	3.65	Yes	No	2	8	8
21	R:R:L622	R:R:T598	12.7129	8.84	No	No	0	9	4
22	R:R:I602	R:R:T598	11.1628	3.04	No	No	0	4	4
23	R:R:F601	R:R:V610	12.7867	3.93	Yes	No	0	8	9
24	R:R:F601	R:R:K821	31.3252	4.96	Yes	Yes	2	8	9
25	R:R:T607	R:R:V610	10.6178	3.17	Yes	No	0	9	9
26	R:R:K821	R:R:V609	10.5723	3.04	Yes	Yes	2	9	6
27	R:R:E770	R:R:K821	11.407	6.75	Yes	Yes	2	9	9
28	R:R:A661	R:R:I621	44.9637	3.25	No	Yes	0	7	8
29	R:R:A661	R:R:L617	29.4288	4.73	No	Yes	0	7	8
30	R:R:L617	R:R:Q693	23.4726	5.32	Yes	Yes	5	8	8
31	R:R:A661	R:R:I620	18.0445	3.25	No	No	0	7	6
32	R:R:I620	R:R:L694	16.4604	1.43	No	No	0	6	5
33	R:R:I621	R:R:S658	97.7459	3.1	Yes	No	0	8	6
34	R:R:S658	R:R:Y659	97.5415	3.82	No	Yes	0	6	7
35	R:R:P655	R:R:Y659	68.442	4.17	Yes	Yes	3	8	7
36	R:R:P655	R:R:S654	23.8871	3.56	Yes	No	0	8	7
37	R:R:L627	R:R:S654	20.1965	4.5	No	No	0	5	7
38	R:R:L627	R:R:M657	16.5285	4.24	No	No	0	5	5
39	R:R:P655	R:R:W785	24.5969	5.4	Yes	Yes	3	8	8
40	R:R:L744	R:R:W785	46.5365	7.97	No	Yes	0	8	8
41	R:R:F788	R:R:L744	42.2893	7.31	Yes	No	0	9	8
42	R:R:I751	R:R:Y659	30.3486	8.46	Yes	Yes	3	8	7
43	R:R:I751	R:R:W785	37.8265	10.57	Yes	Yes	3	8	8
44	R:R:N747	R:R:P655	29.4402	13.03	No	Yes	3	7	8
45	R:R:N747	R:R:Q704	41.0459	5.28	No	Yes	0	7	9
46	R:R:I708	R:R:Q704	16.8578	4.12	No	Yes	0	6	9
47	R:R:F712	R:R:I708	15.3816	5.02	Yes	No	0	6	6
48	R:R:L731	R:R:Q647	14.8138	3.99	No	Yes	0	6	8
49	R:R:I701	R:R:M657	13.3602	5.83	No	No	0	7	5
50	R:R:I701	R:R:L653	10.6405	2.85	No	No	0	7	6
51	R:R:T781	R:R:Y659	10.7427	7.49	Yes	Yes	3	9	7
52	R:R:Q704	R:R:Y746	13.6214	7.89	Yes	Yes	0	9	8
53	R:R:F818	R:R:M817	19.4697	6.22	Yes	No	0	8	8
54	R:R:L662	R:R:M817	13.8826	4.24	No	No	0	6	8
55	R:R:C754	R:R:L662	13.4681	4.76	No	No	0	8	6
56	R:R:C754	R:R:V663	21.5194	3.42	No	No	0	8	7
57	R:R:T666	R:R:V663	19.8217	3.17	No	No	0	9	7
58	R:R:T666	R:R:Y757	18.141	4.99	No	No	0	9	7
59	R:R:Q693	R:R:R668	22.5585	8.18	Yes	No	0	8	8
60	R:R:M688	R:R:R668	21.2298	9.93	No	No	0	5	8
61	R:R:M688	R:R:R671	18.0559	6.2	No	Yes	0	5	7
62	R:R:R671	R:R:Y667	14.5866	15.43	Yes	No	0	7	5
63	R:R:A670	R:R:R671	26.34	1.38	No	Yes	0	6	7
64	R:R:A670	R:R:T761	24.7786	1.68	No	No	0	6	8
65	R:R:T761	R:R:V764	21.6216	3.17	No	Yes	0	8	8
66	R:R:?691	R:R:L694	13.258	3.54	Yes	No	0	3	5
67	R:R:P743	R:R:Q704	12.395	6.32	No	Yes	0	7	9
68	R:R:I719	R:R:L731	11.2367	4.28	Yes	No	0	6	6
69	R:R:F788	R:R:Y792	29.0711	13.41	Yes	Yes	7	9	8
70	R:R:F793	R:R:Y792	11.5717	6.19	Yes	Yes	0	6	8
71	R:R:I751	R:R:M778	25.4599	4.37	Yes	Yes	3	8	9
72	R:R:M778	R:R:T755	20.9459	7.53	Yes	No	0	9	8
73	R:R:T755	R:R:Y779	16.8465	2.5	No	No	0	8	9
74	R:R:F759	R:R:Y779	10.6121	5.16	No	No	0	8	9
75	R:R:P765	R:R:V764	11.8783	3.53	No	Yes	0	9	8
76	R:R:N769	R:R:P765	10.2146	4.89	No	No	0	9	9
77	R:R:M817	R:R:T777	10.1295	6.02	No	Yes	0	8	9
78	R:R:?634	R:R:F633	30.6666	3.12	Yes	Yes	0	5	6
79	R:R:?634	R:R:Q647	18.141	9.08	Yes	Yes	1	5	8
80	R:R:F818	R:R:L622	11.2196	9.74	Yes	No	0	8	9
81	R:R:F818	R:R:V597	10.1011	3.93	Yes	Yes	2	8	6
82	R:R:Y667	R:R:Y757	15.0182	8.94	No	No	0	5	7
83	R:R:C754	R:R:M778	22.8878	8.1	No	Yes	0	8	9
84	R:R:N747	R:R:W785	12.7129	5.65	No	Yes	3	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9HC3

PDB Summary
PDB	9HC3
Class	C
SubFamily	Aminoacid
Type	Metabotropic Glutamate
SubType	mGlu5
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.9
Date	2025-06-25
D.O.I.	doi.org/10.1002/pro.70104

Net Summary
I_min	2.85
Number of Linked Nodes	239
Number of Links	279
Number of Hubs	46
Number of Links mediated by Hubs	166
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	42616
Length Of Smallest Path	3
Average Path Length	13.2904
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	5.01623
Maximum Path Strength	17.61
Minimum Path Correlation	0.7
Average Path Correlation	0.937353
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.8018
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.6166
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein tyrosine kinase activator activity • enzyme regulator activity • kinase activator activity • enzyme activator activity • molecular function activator activity • molecular function regulator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • glutamate receptor activity • G protein-coupled glutamate receptor activity • molecular transducer activity • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein binding • binding • A2A adenosine receptor binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration • neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential • protein tyrosine kinase binding • kinase binding • enzyme binding • protein kinase binding • identical protein binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • system process • learning • learning or memory • nervous system process • cognition • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • cellular component organization • cell junction organization • synapse organization • cellular component organization or biogenesis • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • regulation of metabolic process • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of long-term neuronal synaptic plasticity • regulation of developmental process • cellular developmental process • modulation of chemical synaptic transmission • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of long-term neuronal synaptic plasticity • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of biological quality • system development • regulation of neuronal synaptic plasticity • regulation of synaptic plasticity • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • regulation of trans-synaptic signaling • positive regulation of multicellular organismal process • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • glial cell projection • cell projection • plasma membrane bounded cell projection • astrocyte projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • cytoplasm • glutamatergic synapse • dendritic shaft • neuron spine • dendritic spine • Schaffer collateral - CA1 synapse • cell body • neuronal cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YCM
PDB Residues	R:R:?634 R:R:?691
Environment Details	Open EMBL-EBI Page
Code	YCM
Name	Cysteine-S-acetamide
Synonyms	CYSTEINE-S-ACETAMIDE
Identifier
Formula	C5 H10 N2 O3 S
Molecular Weight	178.209
SMILES
PubChem	36688842
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41594
Sequence	>9HC3_Chain_R P V Q Y L R W G D P P I A A V V F A C L G L L A T L F V T V V F I I Y R D T P V V K S S S R E L C Y I I L A G I C L G Y L C T F L I A K P K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T R A R I L A S K K K I M S A A Q L V I A F I L I C I Q L G I I V A L F I M E P P D I M H E V Y L I C N T T N L G V V P L G Y N G L L I L C T F Y A F K T R N V P A N F N E A K Y I A F T M Y T T C I I W L A F V P I Y F G S N Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R N V R A S A ?Y A M ?A A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X0B	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.1	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0C	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.2	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0D	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.5	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0F	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	VU0424465	-	3.3	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	6FFI	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	MMPEP	-	2.2	2018-03-07	doi.org/10.1021/acs.jmedchem.7b01722
	4OO9	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	Mavoglurant	-	2.6	2014-07-02	doi.org/10.1038/nature13396
	5CGC	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	HTL14242	-	3.1	2015-08-12	doi.org/10.1021/acs.jmedchem.5b00892
	5CGD	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	HTL14242	-	2.6	2015-08-12	doi.org/10.1021/acs.jmedchem.5b00892
	6FFH	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	Fenobam	-	2.65	2018-03-07	doi.org/10.1021/acs.jmedchem.7b01722
	8T6J	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	-	CDPPB	-	3.5	2023-10-11	doi.org/10.1101/2023.08.29.555158
	8TAO	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	CDPPB	-	2.9	2023-10-11	doi.org/10.1101/2023.08.29.555158
	7P2L	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	4YI	-	2.54	2021-09-08	doi.org/10.1016/j.celrep.2021.109648
	9HC0	C	Aminoacid	Metabotropic Glutamate	mGlu₅	Homo sapiens	-	4YI	-	2.33	2025-06-25	doi.org/10.1002/pro.70104
	7FD8	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.8	2021-09-08	doi.org/10.1016/j.celrep.2021.109648
	7FD9	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	LY341495	-	-	4	2021-09-08	doi.org/10.1016/j.celrep.2021.109648
	6N51	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	4	2019-01-23	doi.org/10.1038/s41586-019-0881-4
	6N52	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	-	-	-	4	2019-01-23	doi.org/10.1038/s41586-019-0881-4
	8T7H	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.3	2023-10-11	doi.org/10.1101/2023.08.29.555158
	8T8M	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3	2023-10-11	doi.org/10.1101/2023.08.29.555158
	8X0E	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3.4	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0G	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	3	2024-11-06	doi.org/10.1038/s41467-024-55439-9
	8X0H	C	Aminoacid	Metabotropic Glutamate	mGlu5; mGlu5	Homo sapiens	Quisqualate	-	-	4.1	2024-11-06	doi.org/10.1038/s41467-024-55439-9

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