Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M31 4.83615
2R:R:F41 6.086518
3R:R:H44 5.134517
4R:R:K51 7.615353
5R:R:E62 10.435413
6R:R:I66 6.2575416
7R:R:Q67 3.71333617
8R:R:R68 8.68143714
9R:R:E70 7.282517
10R:R:M72 4.246518
11R:R:L76 2.89517
12R:R:I79 4.3725419
13R:R:L85 6.802516
14R:R:L86 4.53333619
15R:R:I89 3.87167615
16R:R:L91 3.8225419
17R:R:E94 8.3545225
18R:R:I95 4.715407
19R:R:R96 14.4365224
20R:R:C99 6.1725417
21R:R:H101 3.446504
22R:R:I110 3.868535
23R:R:F112 5.8145226
24R:R:D115 6.50254225
25R:R:K141 8.005404
26R:R:P149 3.59506
27R:R:L164 3.645435
28R:R:F165 6.83667637
29R:R:P168 3.4075419
30R:R:Q169 5.0875438
31R:R:Y172 8.878517
32R:R:S173 4.335415
33R:R:M177 4.3125405
34R:R:L179 5.436538
35R:R:F185 4.62536
36R:R:F188 8.48538
37R:R:M189 3.4225406
38R:R:R190 7.006539
39R:R:P193 4.478548
40R:R:D195 10.1448
41R:R:Q198 7.885649
42R:R:R208 7.655445
43R:R:Y213 4.16143769
44R:R:E220 6.5475407
45R:R:Y223 6.79714747
46R:R:M228 5.444384
47R:R:F231 2.826676385
48R:R:C241 4.1125469
49R:R:Y246 6.404505
50R:R:L261 4585
51R:R:T265 5.665484
52R:R:H267 5.96463
53R:R:L268 8.745484
54R:R:R272 9.4925485
55R:R:F277 8.60333647
56R:R:T282 6.58754284
57R:R:F299 5.865487
58R:R:L302 4.3775407
59R:R:D305 5.496548
60R:R:W307 8.463336107
61R:R:V313 3.935104
62R:R:T314 3.6854103
63R:R:Y317 5.8625393
64R:R:E320 4.88254394
65R:R:F337 8.255417
66R:R:Y341 6.718516
67R:R:L344 4.4825414
68R:R:R345 5.6875414
69R:R:P346 10.01516
70R:R:N349 9.2275414
71R:R:N352 6.67857717
72R:R:W354 8.00429715
73R:R:F355 7.8825414
74R:R:F358 10.7675416
75R:R:W359 7.39143717
76R:R:H361 7.034293
77R:R:F363 8.225417
78R:R:F370 15.335412
79R:R:K376 9.99754291
80R:R:Y377 18.25254291
81R:R:H391 7.325414
82R:R:Q393 5.4475415
83R:R:D394 5.274515
84R:R:K396 4.0425414
85R:R:Y405 4.9354247
86R:R:M407 4.515405
87R:R:M414 5.754515
88R:R:Q415 5.6375414
89R:R:L418 3.695413
90R:R:C419 4.85413
91R:R:M429 4.86333613
92R:R:K436 5.655417
93R:R:L437 4.455417
94R:R:L441 3.63416
95R:R:F446 6.412508
96R:R:V449 3.155403
97R:R:F456 3.07509
98R:R:Y466 5.69549
99R:R:N470 4.19408
100R:R:F471 5.60254106
101R:R:Y481 6.12754104
102R:R:W487 6.26833646
103R:R:L492 5.4575445
104R:R:M494 6.4775446
105R:R:W500 7.66407
106R:R:C511 5.2125469
107R:R:C515 4.062569
108R:R:I520 4.14466
109R:R:K521 7.7554118
110R:R:V528 6.555466
111R:R:C530 4.5275469
112R:R:C531 4.29469
113R:R:W532 19.0975468
114R:R:T535 3.49754114
115R:R:E541 7.2945117
116R:R:Y542 4.268336147
117R:R:C552 5.62754149
118R:R:S556 7.06754145
119R:R:P558 2.8554148
120R:R:C565 4.97754149
121R:R:T607 2.6575409
122R:R:V609 4.2125456
123R:R:Y629 5.583336438
124R:R:L635 10.854167
125R:R:P639 4.65754159
126R:R:Q647 7.1185168
127R:R:I649 5.494175
128R:R:I651 3.56754167
129R:R:Y659 5.0175407
130R:R:Q704 4.9265179
131R:R:I708 4.4154176
132R:R:H721 4.774152
133R:R:V729 4.895157
134R:R:Y730 7.3365306
135R:R:L731 7.174156
136R:R:Y746 7.35178
137R:R:I751 3.5345468
138R:R:V764 2.885408
139R:R:N767 6.2654258
140R:R:E770 7.70254259
141R:R:W785 6.08408
142R:R:Y792 6.6985168
143R:R:F793 2.674166
144R:R:M802 5.45754168
145R:R:L814 3.634448
146R:R:F818 4.576508
147S:S:M31 4.83625
148S:S:F41 6.086528
149S:S:H44 5.134527
150S:S:K51 7.615483
151S:S:E62 10.435423
152S:S:I66 6.2575426
153S:S:Q67 3.71333627
154S:S:R68 8.53429724
155S:S:E70 7.282527
156S:S:M72 4.246528
157S:S:L76 2.89527
158S:S:I79 4.3725429
159S:S:L85 6.802526
160S:S:L86 4.53333629
161S:S:I89 3.87167625
162S:S:L91 3.8225429
163S:S:E94 8.3545235
164S:S:I95 4.715407
165S:S:R96 14.4365234
166S:S:C99 6.6427
167S:S:H101 3.446504
168S:S:I110 3.868535
169S:S:F112 5.8145236
170S:S:D115 6.50254235
171S:S:K141 8.005404
172S:S:P149 3.59506
173S:S:L164 3.9875435
174S:S:F165 7.04637
175S:S:P168 3.4075429
176S:S:Q169 5.0875438
177S:S:Y172 8.672527
178S:S:S173 4.335425
179S:S:M177 4.3125405
180S:S:L179 5.436538
181S:S:F185 4.62536
182S:S:F188 8.48538
183S:S:M189 3.4225406
184S:S:R190 7.006539
185S:S:P193 4.478558
186S:S:D195 10.1458
187S:S:Q198 7.885659
188S:S:R208 7.655455
189S:S:Y213 4.16143779
190S:S:E220 6.5475407
191S:S:Y223 6.79714757
192S:S:M228 5.444504
193S:S:F231 2.826676505
194S:S:C241 4.1125479
195S:S:Y246 6.404505
196S:S:L261 4595
197S:S:T265 5.665494
198S:S:H267 5.96473
199S:S:L268 8.745494
200S:S:R272 9.4925495
201S:S:F277 8.60333657
202S:S:T282 6.58754314
203S:S:F299 5.865497
204S:S:L302 4.3775407
205S:S:D305 5.496558
206S:S:W307 8.463336127
207S:S:V313 3.935124
208S:S:T314 3.6854123
209S:S:Y317 5.8625513
210S:S:E320 4.88254514
211S:S:F337 8.255427
212S:S:Y341 6.718526
213S:S:L344 4.4825424
214S:S:R345 5.6875424
215S:S:P346 10.01526
216S:S:N349 9.2275424
217S:S:N352 6.67857727
218S:S:W354 8.00429725
219S:S:F355 7.8825424
220S:S:F358 10.7675426
221S:S:W359 7.39143727
222S:S:H361 7.034323
223S:S:F363 8.225427
224S:S:F370 15.335422
225S:S:K376 9.99754321
226S:S:Y377 18.25254321
227S:S:H391 7.325424
228S:S:Q393 5.4475425
229S:S:D394 5.274525
230S:S:K396 4.0425424
231S:S:Y405 4.9354267
232S:S:M407 4.515405
233S:S:M414 5.754525
234S:S:Q415 5.6375424
235S:S:L418 3.695423
236S:S:C419 4.85423
237S:S:M429 4.86333623
238S:S:K436 5.655427
239S:S:L437 4.455427
240S:S:L441 3.63426
241S:S:F446 6.412508
242S:S:V449 3.155403
243S:S:F456 3.07509
244S:S:Y466 5.69559
245S:S:N470 4.19408
246S:S:F471 5.60254126
247S:S:Y481 6.12754124
248S:S:W487 6.26833656
249S:S:L492 5.4575455
250S:S:M494 6.4775456
251S:S:W500 7.66407
252S:S:C511 5.2125479
253S:S:C515 4.062579
254S:S:I520 4.14476
255S:S:K521 7.7554138
256S:S:V528 6.555476
257S:S:C530 4.5275479
258S:S:C531 4.29479
259S:S:W532 19.0975478
260S:S:T535 3.49754134
261S:S:E541 7.2945137
262S:S:Y542 4.268336187
263S:S:C552 5.62754189
264S:S:S556 7.06754185
265S:S:P558 2.8554188
266S:S:C565 4.97754189
267S:S:T607 2.6575409
268S:S:V609 4.2125576
269S:S:Y629 5.583336558
270S:S:L635 10.854207
271S:S:P639 4.65754199
272S:S:Q647 7.1185208
273S:S:I649 5.494215
274S:S:I651 3.56754207
275S:S:Y659 5.0175407
276S:S:Q704 4.9265219
277S:S:I708 4.4154216
278S:S:H721 4.774192
279S:S:V729 4.895197
280S:S:Y730 7.3365336
281S:S:L731 7.174196
282S:S:Y746 7.35218
283S:S:I751 3.5345588
284S:S:V764 2.885408
285S:S:N767 6.2654278
286S:S:E770 7.70254279
287S:S:W785 6.08408
288S:S:Y792 6.6985208
289S:S:F793 2.674206
290S:S:M802 5.45754208
291S:S:L814 3.634568
292S:S:F818 4.576508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F165 R:R:I167 50.72062.51YesNo076
2S:S:F165 S:S:L164 49.43143.65YesYes375
3R:R:F188 R:R:Q169 51.02635.86YesYes388
4R:R:F188 R:R:L179 49.356610.96YesYes388
5R:R:I156 R:R:Q157 24.68322.74NoNo055
6R:R:Q157 S:S:L164 24.692.66NoYes055
7R:R:F185 R:R:N160 24.78153.62YesNo365
8R:R:N160 S:S:L164 24.8235.49NoYes355
9R:R:L162 R:R:Q169 46.31962.66NoYes078
10R:R:F165 R:R:L164 49.43143.65YesYes375
11R:R:L164 S:S:Q157 24.692.66YesNo055
12R:R:L164 S:S:N160 24.8234.12YesNo355
13R:R:Q198 R:R:Y466 76.44836.76YesYes499
14R:R:P193 R:R:Y466 96.59236.95YesYes489
15R:R:L329 R:R:P193 97.23523.28NoYes058
16R:R:F399 R:R:L329 97.33428.53NoNo075
17R:R:F399 R:R:V192 98.85446.55NoNo077
18R:R:R190 R:R:V192 98.94073.92YesNo097
19R:R:F188 R:R:R190 1006.41YesYes389
20R:R:D305 R:R:Q198 75.010313.05YesYes489
21R:R:W487 R:R:Y466 20.84617.72YesYes469
22R:R:L492 R:R:W487 18.38956.83YesYes456
23R:R:L492 R:R:M494 17.87115.65YesYes456
24R:R:A308 R:R:D305 74.94141.54NoYes058
25R:R:A308 R:R:D309 73.77721.54NoNo055
26R:R:D309 R:R:R310 73.67142.38NoNo055
27R:R:D312 R:R:R310 73.565616.68NoNo015
28R:R:D312 R:R:R284 70.74625.96NoNo1012
29R:R:M281 R:R:R284 71.01522.48NoNo022
30R:R:E279 R:R:M281 70.90874.06NoNo042
31R:R:E279 R:R:T282 70.58957.06NoYes044
32R:R:I248 R:R:T282 69.86714.56NoYes2864
33R:R:I248 R:R:L260 69.77965.71NoNo065
34R:R:L260 R:R:Y246 69.67475.86NoYes055
35R:R:H267 R:R:Y246 72.19385.44YesYes035
36R:R:H267 R:R:Y213 74.82715.44YesYes639
37R:R:C511 R:R:Y213 73.33795.38YesYes699
38R:R:I506 R:R:R272 17.37852.51NoYes045
39R:R:I506 R:R:W500 17.43777.05NoYes047
40R:R:V499 R:R:W500 17.166512.26NoYes077
41R:R:N470 R:R:V499 17.22635.91YesNo087
42R:R:N470 R:R:V484 17.88562.96YesNo088
43R:R:M494 R:R:V484 17.88133.04YesNo468
44R:R:D258 R:R:L293 10.584412.21NoNo033
45R:R:F299 R:R:T265 16.1877.78YesYes874
46R:R:C515 R:R:V522 71.88165.12YesNo695
47R:R:V522 R:R:W532 71.944515.94NoYes658
48R:R:S512 R:R:W532 72.9622.47NoYes688
49R:R:C511 R:R:S512 72.96511.72YesNo698
50R:R:C515 R:R:I520 71.26531.64YesYes696
51R:R:L562 R:R:V543 67.54314.47NoNo067
52R:R:K521 R:R:V543 67.665318.21YesNo087
53R:R:K521 R:R:T535 70.46221.5YesYes1184
54R:R:P536 R:R:T535 70.82491.75NoYes034
55R:R:I520 R:R:P536 70.94575.08YesNo063
56R:R:L562 R:R:P558 67.29841.64NoYes068
57R:R:I568 R:R:W557 65.08684.7NoNo087
58R:R:P558 R:R:W557 65.21021.35YesNo087
59R:R:I568 R:R:V729 64.847.68NoYes087
60R:R:H721 R:R:V729 32.16024.15YesYes1527
61R:R:V570 R:R:V729 32.16033.21NoYes1547
62R:R:L731 R:R:V570 32.030313.41YesNo1564
63R:R:H721 R:R:L731 32.04292.57YesYes1526
64R:R:T801 R:R:Y797 11.01284.99NoNo085
65R:R:F788 R:R:T801 12.11292.59NoNo098
66R:R:F788 R:R:Y792 13.21286.19NoYes098
67R:R:M802 R:R:Y792 17.61013.59YesYes1688
68R:R:Q647 R:R:R648 34.95775.84YesNo1688
69R:R:R648 R:R:T735 59.80472.59NoNo086
70R:R:C733 R:R:T735 60.07181.69NoNo096
71R:R:C733 R:R:P639 60.33311.88NoYes1599
72R:R:L731 R:R:P639 63.54039.85YesYes1569
73R:R:I651 R:R:R648 24.57972.51YesNo1678
74R:R:C803 R:R:L635 25.22124.76NoYes077
75R:R:L635 R:R:Q647 25.546117.3YesYes1678
76R:R:F586 R:R:S807 22.19615.28NoNo038
77R:R:S807 R:R:T632 22.47143.2NoNo087
78R:R:C803 R:R:T632 23.02188.45NoNo077
79R:R:F586 R:R:T811 21.645410.38NoNo036
80R:R:T811 R:R:Y629 21.36996.24NoYes068
81R:R:L622 R:R:T594 15.84994.42NoNo097
82R:R:T594 R:R:Y629 16.67922.5NoYes078
83R:R:F818 R:R:L622 15.57333.65YesNo089
84R:R:W785 R:R:Y659 10.3386.75YesYes087
85R:R:P655 R:R:W785 13.68315.4NoYes088
86R:R:P655 R:R:S654 14.23893.56NoNo087
87R:R:G628 R:R:S654 14.51673.71NoNo067
88R:R:C631 R:R:G628 15.07213.92NoNo076
89R:R:C631 R:R:I651 15.62743.27NoYes077
90S:S:F165 S:S:I167 50.72062.51YesNo076
91S:S:I167 S:S:L162 46.42964.28NoNo067
92S:S:L162 S:S:Q169 46.31962.66NoYes078
93S:S:F188 S:S:Q169 51.02635.86YesYes388
94S:S:F188 S:S:R190 1006.41YesYes389
95S:S:R190 S:S:V192 98.94073.92YesNo097
96S:S:F399 S:S:V192 98.85446.55NoNo077
97S:S:F399 S:S:K396 12.68773.72NoYes074
98S:S:I156 S:S:Q157 24.68322.74NoNo055
99S:S:I156 S:S:L179 24.68064.28NoYes358
100S:S:F185 S:S:N160 24.78153.62YesNo365
101S:S:F185 S:S:L179 24.8024.87YesYes368
102S:S:F188 S:S:L179 49.356610.96YesYes388
103S:S:F399 S:S:L329 97.33428.53NoNo075
104S:S:L329 S:S:P193 97.23523.28NoYes058
105S:S:P193 S:S:Y466 96.59236.95YesYes589
106S:S:Q198 S:S:Y466 76.44936.76YesYes599
107S:S:D305 S:S:Q198 75.011313.05YesYes589
108S:S:W487 S:S:Y466 20.84717.72YesYes569
109S:S:L492 S:S:W487 18.39066.83YesYes556
110S:S:L492 S:S:M494 17.87115.65YesYes556
111S:S:A308 S:S:D305 74.94241.54NoYes058
112S:S:A308 S:S:D309 73.77821.54NoNo055
113S:S:D309 S:S:R310 73.67242.38NoNo055
114S:S:D312 S:S:R310 73.566616.68NoNo015
115S:S:D312 S:S:R284 70.74735.96NoNo1212
116S:S:M281 S:S:R284 71.01622.48NoNo022
117S:S:E279 S:S:M281 70.90974.06NoNo042
118S:S:E279 S:S:T282 70.59017.06NoYes044
119S:S:I248 S:S:T282 69.86684.56NoYes3164
120S:S:I248 S:S:L260 69.77875.71NoNo065
121S:S:L260 S:S:Y246 69.67365.86NoYes055
122S:S:H267 S:S:Y246 72.16375.44YesYes035
123S:S:H267 S:S:Y213 74.76725.44YesYes739
124S:S:C511 S:S:Y213 73.27925.38YesYes799
125S:S:M494 S:S:V484 18.393.04YesNo568
126S:S:N470 S:S:V484 18.39422.96YesNo088
127S:S:N470 S:S:V499 17.73345.91YesNo087
128S:S:V499 S:S:W500 17.673312.26NoYes077
129S:S:I506 S:S:W500 17.37227.05NoYes047
130S:S:I506 S:S:R272 17.3132.51NoYes045
131S:S:F299 S:S:T265 16.12197.78YesYes974
132S:S:D258 S:S:L293 10.582412.21NoNo033
133S:S:C511 S:S:S512 72.90681.72YesNo798
134S:S:S512 S:S:W532 72.90382.47NoYes788
135S:S:V522 S:S:W532 71.887115.94NoYes758
136S:S:C515 S:S:V522 71.82435.12YesNo795
137S:S:C515 S:S:I520 71.20851.64YesYes796
138S:S:I520 S:S:P536 70.88935.08YesNo063
139S:S:P536 S:S:T535 70.76861.75NoYes034
140S:S:K521 S:S:T535 70.40621.5YesYes1384
141S:S:K521 S:S:V543 67.611818.21YesNo087
142S:S:L562 S:S:V543 67.48974.47NoNo067
143S:S:L562 S:S:P558 67.24521.64NoYes068
144S:S:P558 S:S:W557 65.15881.35YesNo087
145S:S:I568 S:S:W557 65.03564.7NoNo087
146S:S:I568 S:S:V729 64.7897.68NoYes087
147S:S:H721 S:S:V729 32.13494.15YesYes1927
148S:S:V570 S:S:V729 32.1353.21NoYes1947
149S:S:L731 S:S:V570 32.005113.41YesNo1964
150S:S:H721 S:S:L731 32.01772.57YesYes1926
151S:S:L731 S:S:P639 63.49039.85YesYes1969
152S:S:C733 S:S:P639 60.28561.88NoYes1999
153S:S:C733 S:S:T735 60.02471.69NoNo096
154S:S:R648 S:S:T735 59.75772.59NoNo086
155S:S:Q647 S:S:R648 34.93035.84YesNo2088
156S:S:M802 S:S:Y792 17.59643.59YesYes2088
157S:S:F788 S:S:Y792 13.20256.19NoYes098
158S:S:F788 S:S:T801 12.10342.59NoNo098
159S:S:T801 S:S:Y797 11.00424.99NoNo085
160S:S:I651 S:S:R648 24.56042.51YesNo2078
161S:S:L635 S:S:Q647 25.526217.3YesYes2078
162S:S:C803 S:S:L635 25.20174.76NoYes077
163S:S:C803 S:S:T632 23.0048.45NoNo077
164S:S:S807 S:S:T632 22.4543.2NoNo087
165S:S:F586 S:S:S807 22.17895.28NoNo038
166S:S:F586 S:S:T811 21.628610.38NoNo036
167S:S:T811 S:S:Y629 21.35346.24NoYes068
168S:S:T594 S:S:Y629 16.66642.5NoYes078
169S:S:L622 S:S:T594 15.83764.42NoNo097
170S:S:F818 S:S:L622 15.56133.65YesNo089
171S:S:C631 S:S:I651 15.61533.27NoYes077
172S:S:C631 S:S:G628 15.06063.92NoNo076
173S:S:G628 S:S:S654 14.50553.71NoNo067
174S:S:P655 S:S:S654 14.2283.56NoNo087
175S:S:P655 S:S:W785 13.67265.4NoYes088
176S:S:W785 S:S:Y659 10.33016.75YesYes087
177R:R:I156 R:R:L179 24.68064.28NoYes358
178R:R:F185 R:R:L179 24.8024.87YesYes368
179R:R:I167 R:R:L162 46.42964.28NoNo067
180R:R:F399 R:R:K396 12.68773.72NoYes074
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 6N52
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu5; mGlu5
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 4
Date 2019-01-23
D.O.I. 10.1038/s41586-019-0881-4
Net Summary
Imin 2.48
Number of Linked Nodes 1468
Number of Links 1803
Number of Hubs 292
Number of Links mediated by Hubs 1059
Number of Communities 59
Number of Nodes involved in Communities 526
Number of Links involved in Communities 747
Path Summary
Number Of Nodes in MetaPath 181
Number Of Links MetaPath 180
Number of Shortest Paths 5765211
Length Of Smallest Path 3
Average Path Length 64.5489
Length of Longest Path 136
Minimum Path Strength 1.355
Average Path Strength 5.77668
Maximum Path Strength 33.665
Minimum Path Correlation 0.72
Average Path Correlation 0.998727
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 45.1111
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.5863
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41594
Sequence
>6N52_Chain_R
RVVAHMPGD IIIGALFSV HHQPTVDKV HERKCGAVR EQYGIQRVE 
AMLHTLERI NSDPTLLPN ITLGCEIRD SCWHSAVAL EQSIEFIRD 
SLISSEESF RSKKPIVGV IGPGSSSVA IQVQNLLQL FNIPQIAYS 
ATSMDLSDK TLFKYFMRV VPSDAQQAR AMVDIVKRY NWTYVSAVH 
TEGNYGESG MEAFKDMSA KEGICIAHS YKIYSNAGE QSFDKLLKK 
LTSHLPKAR VVACFCEGM TVRGLLMAM RRLGLAGEF LLLGSDGWA 
DRYDVTDGY QREAVGGIT IKLQSPDVK WFDDYYLKL RPETNHRNP 
WFQEFWQHR FQCRLEGFP QENSKYNKT CNSSLTLKT HHVQDSKMG 
FVINAIYSM AYGLHNMQM SLCPGYAGL CDAMKPIDG RKLLESLMK 
TNFTGVSGD TILFDENGD SPGRYEIMN FKEMGKDYF DYINVGSWD 
NGELKMDDD EVWSKKSNI IRSVCSEPC EKGQIKVIR KGEVSCCWT 
CTPCKENEY VFDEYTCKA CQLGSWPTD DLTGCDLIP VQYLRWGDP 
EPIAAVVFA CLGLLATLF VTVVFIIYR DTPVVKSSS RELCYIILA 
GICLGYLCT FCLIAKPKQ IYCYLQRIG IGLSPAMSY SALVTKTNR 
IACAQLVIA FILICIQLG IIVALFIME PPDIMHDYP SIREVYLIC 
NTTNLGVVT PLGYNGLLI LSCTFYAFK TRNVPANFN EAKYIAFTM 
YTTCIIWLA FVPIYFGSN YKIITMCFS VSLSATVAL GCMFVPKVY 
IILAKPERN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41594
Sequence
>6N52_Chain_S
RVVAHMPGD IIIGALFSV HHQPTVDKV HERKCGAVR EQYGIQRVE 
AMLHTLERI NSDPTLLPN ITLGCEIRD SCWHSAVAL EQSIEFIRD 
SLISSEESF RSKKPIVGV IGPGSSSVA IQVQNLLQL FNIPQIAYS 
ATSMDLSDK TLFKYFMRV VPSDAQQAR AMVDIVKRY NWTYVSAVH 
TEGNYGESG MEAFKDMSA KEGICIAHS YKIYSNAGE QSFDKLLKK 
LTSHLPKAR VVACFCEGM TVRGLLMAM RRLGLAGEF LLLGSDGWA 
DRYDVTDGY QREAVGGIT IKLQSPDVK WFDDYYLKL RPETNHRNP 
WFQEFWQHR FQCRLEGFP QENSKYNKT CNSSLTLKT HHVQDSKMG 
FVINAIYSM AYGLHNMQM SLCPGYAGL CDAMKPIDG RKLLESLMK 
TNFTGVSGD TILFDENGD SPGRYEIMN FKEMGKDYF DYINVGSWD 
NGELKMDDD EVWSKKSNI IRSVCSEPC EKGQIKVIR KGEVSCCWT 
CTPCKENEY VFDEYTCKA CQLGSWPTD DLTGCDLIP VQYLRWGDP 
EPIAAVVFA CLGLLATLF VTVVFIIYR DTPVVKSSS RELCYIILA 
GICLGYLCT FCLIAKPKQ IYCYLQRIG IGLSPAMSY SALVTKTNR 
IACAQLVIA FILICIQLG IIVALFIME PPDIMHDYP SIREVYLIC 
NTTNLGVVT PLGYNGLLI LSCTFYAFK TRNVPANFN EAKYIAFTM 
YTTCIIWLA FVPIYFGSN YKIITMCFS VSLSATVAL GCMFVPKVY 
IILAKPERN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4OO9CAminoacidMetabotropic glutamatemGlu5Homo sapiens-Mavoglurant-2.62014-07-0210.1038/nature13396
5CGCCAminoacidMetabotropic glutamatemGlu5Homo sapiens-HTL14242-3.12015-08-1210.1021/acs.jmedchem.5b00892
5CGDCAminoacidMetabotropic glutamatemGlu5Homo sapiens-HTL14242-2.62015-08-1210.1021/acs.jmedchem.5b00892
6FFHCAminoacidMetabotropic glutamatemGlu5Homo sapiens-Fenobam-2.652018-03-0710.1021/acs.jmedchem.7b01722
6FFICAminoacidMetabotropic glutamatemGlu5Homo sapiens-MMPEP-2.22018-03-0710.1021/acs.jmedchem.7b01722
7P2LCAminoacidMetabotropic glutamatemGlu5Homo sapiens-4YI-2.542021-09-0810.1016/j.celrep.2021.109648
6N51CAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--42019-01-2310.1038/s41586-019-0881-4
6N52CAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiens---42019-01-2310.1038/s41586-019-0881-4
7FD8CAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.82021-09-0810.1016/j.celrep.2021.109648
7FD9CAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensLY341495--42021-09-0810.1016/j.celrep.2021.109648
8T6JCAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiens-CDPPB-3.52023-10-1110.1101/2023.08.29.555158
8T7HCAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.32023-10-1110.1101/2023.08.29.555158
8T8MCAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--32023-10-1110.1101/2023.08.29.555158
8TAOCAminoacidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualateCDPPB-2.92023-10-1110.1101/2023.08.29.555158




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6N52.zip



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