Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M31 4.15333625
2R:R:F41 11.432528
3R:R:H44 5.134517
4R:R:K51 9.124343
5R:R:R55 20.49254122
6R:R:E62 9.2825413
7R:R:I66 6.2575416
8R:R:Q67 5.8425417
9R:R:R68 23.7775424
10R:R:E70 7.282517
11R:R:M72 4.246528
12R:R:L76 3.176527
13R:R:L85 5.76167626
14R:R:L86 4.396529
15R:R:I89 4.54286725
16R:R:E94 9.2356125
17R:R:I95 4.715407
18R:R:R96 13.975124
19R:R:C99 6.1725417
20R:R:H101 3.446504
21R:R:I110 3.8685185
22R:R:F112 6.9054126
23R:R:D115 6.84754125
24R:R:K141 10.17336124
25R:R:I143 4.054126
26R:R:P149 3.59506
27R:R:F165 7.7025187
28R:R:P168 3.4075429
29R:R:Y172 10.936527
30R:R:M177 4.3125405
31R:R:L179 5.4365148
32R:R:F185 4.625146
33R:R:F188 8.485148
34R:R:M189 3.4225406
35R:R:R190 7.0065149
36R:R:P193 4.4785198
37R:R:Q198 8.6656199
38R:R:R208 7.6554215
39R:R:Y213 6.77649
40R:R:T219 3.2245285
41R:R:Y223 5.7165197
42R:R:Y246 8.1375405
43R:R:L261 4.1875405
44R:R:H267 11.0175443
45R:R:F277 7.6507
46R:R:F299 5.18547
47R:R:L302 4.3775407
48R:R:D305 5.4965198
49R:R:W307 8.463336207
50R:R:V313 3.81754204
51R:R:T314 4.9954203
52R:R:W336 10.044245
53R:R:F337 8.255417
54R:R:Y341 6.718516
55R:R:L344 4.4825414
56R:R:P346 9.825416
57R:R:N349 9.2275414
58R:R:N352 6.67857717
59R:R:W354 9.08833615
60R:R:F355 7.8825414
61R:R:W359 7.68857717
62R:R:F363 8.225417
63R:R:L367 12.24412
64R:R:F370 9.958512
65R:R:H391 7.325414
66R:R:D394 3.615405
67R:R:Y405 4.9354247
68R:R:M407 4.515405
69R:R:M414 5.754525
70R:R:L418 3.695423
71R:R:C419 4.85423
72R:R:L425 4.48423
73R:R:M429 5.292523
74R:R:K436 5.655427
75R:R:L437 4.455427
76R:R:L441 3.63426
77R:R:F446 7.355408
78R:R:I454 4.9775407
79R:R:F456 3.1775409
80R:R:Y466 6.4454199
81R:R:N470 4.19408
82R:R:F471 7.815206
83R:R:Y481 5.8154204
84R:R:W487 6.26833606
85R:R:L492 5.45754215
86R:R:M494 6.47754216
87R:R:V528 3.7725446
88R:R:C530 4.9525449
89R:R:N540 4.454228
90R:R:E541 5.774387
91R:R:Y542 7.6754407
92R:R:C552 5.27254229
93R:R:V600 4.774445
94R:R:F601 2.8475408
95R:R:V609 4.875486
96R:R:L617 5.1575488
97R:R:Y629 5.583336428
98R:R:L635 6.7354107
99R:R:Y643 6.9725107
100R:R:Q647 6.4565108
101R:R:I651 6.474107
102R:R:Y659 5.0175407
103R:R:Q704 5.4925409
104R:R:I708 4.4154106
105R:R:F712 11.44754106
106R:R:V729 5.6954417
107R:R:Y730 5.9825306
108R:R:C733 5.87754109
109R:R:Y746 8.4575408
110R:R:N747 6.48254257
111R:R:I751 4.3145258
112R:R:V764 2.9225408
113R:R:N767 9.4425488
114R:R:E770 9.684589
115R:R:Y773 7.8375485
116R:R:W785 7.355258
117R:R:Y792 6.698508
118R:R:M802 5.664108
119R:R:C803 4.53407
120R:R:M817 5.7575488
121R:R:K821 4.7575489
122R:R:I824 3.5975488
123R:R:I825 4.9054448
124R:R:K828 2.6875406
125S:S:M31 4.15333655
126S:S:F41 11.432558
127S:S:H44 5.134537
128S:S:K51 5.1075403
129S:S:R55 20.49254132
130S:S:I66 6.2575436
131S:S:R68 23.7775454
132S:S:E70 7.282537
133S:S:M72 4.246558
134S:S:L76 3.176557
135S:S:I79 4.0225459
136S:S:L85 6.04406
137S:S:L86 4.344559
138S:S:I89 3.87167655
139S:S:L91 3.8475459
140S:S:E94 9.486676135
141S:S:I95 4.715407
142S:S:R96 13.975134
143S:S:C99 6.6437
144S:S:H101 3.446504
145S:S:I110 3.8685185
146S:S:F112 6.61254136
147S:S:D115 6.15754135
148S:S:K141 11.096134
149S:S:I143 4.074136
150S:S:P149 3.59506
151S:S:F165 7.9465187
152S:S:P168 3.40754179
153S:S:Y172 10.936557
154S:S:M177 4.3125405
155S:S:L179 5.4365158
156S:S:F185 4.625156
157S:S:F188 8.485158
158S:S:M189 3.4225406
159S:S:R190 7.0065159
160S:S:P193 4.4785168
161S:S:D195 9.80254168
162S:S:Q198 8.866169
163S:S:R208 7.6554235
164S:S:Y213 6.95167669
165S:S:T219 3.5754315
166S:S:E220 6.375407
167S:S:Y223 6.998336167
168S:S:Y246 6.645405
169S:S:I248 4.89754316
170S:S:L261 3.9625405
171S:S:H267 11.29463
172S:S:R272 8.5925405
173S:S:F277 10.5665167
174S:S:R292 6.6675403
175S:S:F299 7.13567
176S:S:L302 4.3775407
177S:S:D305 6.4854168
178S:S:W307 8.463336117
179S:S:V313 3.81754114
180S:S:F337 8.255437
181S:S:Y341 6.718536
182S:S:L344 4.4825434
183S:S:R345 4.798534
184S:S:P346 10.1875436
185S:S:N349 9.2275434
186S:S:N352 6.67857737
187S:S:W354 10.252535
188S:S:F355 7.8825434
189S:S:W359 8.68167637
190S:S:F363 8.225437
191S:S:F370 9.144502
192S:S:Y377 9.244471
193S:S:H391 7.325434
194S:S:D394 3.615405
195S:S:Y405 4.9354267
196S:S:M407 4.515405
197S:S:M414 5.7545175
198S:S:L418 3.6954173
199S:S:C419 4.854173
200S:S:M429 5.5745173
201S:S:K436 5.6554177
202S:S:L437 4.4554177
203S:S:L441 3.634176
204S:S:F446 7.355408
205S:S:I454 4.9775407
206S:S:F456 3.1775409
207S:S:Y466 6.4454169
208S:S:N470 4.19408
209S:S:F471 8.2165116
210S:S:K472 3.88406
211S:S:F479 9.0565113
212S:S:Y481 5.8154114
213S:S:W487 6.26833606
214S:S:L492 5.45754235
215S:S:M494 6.47754236
216S:S:I520 3.29254496
217S:S:V522 5.755405
218S:S:C530 4.746569
219S:S:E541 6.4454507
220S:S:Y542 6.514527
221S:S:P558 3.265408
222S:S:V600 6.25325
223S:S:V609 4.4975496
224S:S:Y629 5.583336558
225S:S:L635 5.9577
226S:S:Y643 7.198577
227S:S:Q647 7.9325478
228S:S:R648 5.32578
229S:S:Y659 5.0175407
230S:S:Q704 5.4925409
231S:S:I708 4.415476
232S:S:F712 10.665476
233S:S:V729 5.6954547
234S:S:Y730 5.78754336
235S:S:C733 5.1125479
236S:S:Y746 8.4575408
237S:S:N747 6.48254277
238S:S:I751 4.3145278
239S:S:V764 2.9225408
240S:S:N767 9.0925498
241S:S:E770 9.684599
242S:S:Y773 7.54495
243S:S:W785 7.355278
244S:S:Y792 6.698508
245S:S:C803 4.1325407
246S:S:L814 3.25754568
247S:S:M817 5.7575498
248S:S:F818 4.8075408
249S:S:K821 3.765499
250S:S:I825 5.264328
251S:S:K828 2.6875406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:V499 R:R:W500 81.052312.26NoNo077
2R:R:N470 R:R:V499 81.22135.91YesNo087
3R:R:N470 R:R:V484 86.68882.96YesNo088
4R:R:M494 R:R:V484 86.81023.04YesNo2168
5R:R:L492 R:R:M494 86.84535.65YesYes2156
6R:R:L492 R:R:W487 91.46056.83YesYes056
7R:R:W487 R:R:Y466 92.45777.72YesYes069
8R:R:P193 R:R:Y466 98.83346.95YesYes1989
9R:R:L329 R:R:P193 99.85433.28NoYes058
10R:R:F399 R:R:L329 1008.53NoNo075
11R:R:F399 R:R:K396 25.36673.72NoNo074
12R:R:K396 R:R:S173 22.14.59NoNo045
13R:R:S173 R:R:Y172 22.20965.09NoYes057
14R:R:F399 R:R:V192 79.71746.55NoNo077
15R:R:R190 R:R:V192 79.86173.92YesNo097
16R:R:F188 R:R:R190 81.45796.41YesYes1489
17R:R:F188 R:R:L179 82.588710.96YesYes1488
18R:R:F185 R:R:L179 83.10794.87YesYes1468
19R:R:F185 R:R:N160 84.42863.62YesNo065
20R:R:N160 S:S:L164 84.60755.49NoNo055
21R:R:L106 S:S:L164 27.06824.15NoNo1855
22R:R:L106 R:R:L161 27.23622.77NoNo055
23R:R:F165 R:R:L161 38.71123.65YesNo075
24R:R:F165 R:R:L164 50.13733.65YesNo1875
25R:R:L164 S:S:N160 76.97494.12NoNo055
26S:S:F185 S:S:N160 76.78793.62YesNo065
27S:S:F185 S:S:L179 75.48044.87YesYes1568
28S:S:F188 S:S:L179 74.953610.96YesYes1588
29S:S:F188 S:S:R190 73.82416.41YesYes1589
30S:S:R190 S:S:V192 72.23083.92YesNo097
31S:S:F399 S:S:V192 72.08646.55NoNo077
32S:S:F399 S:S:L329 90.33678.53NoNo075
33S:S:L329 S:S:P193 90.18243.28NoYes058
34S:S:P193 S:S:Y466 89.12366.95YesYes1689
35S:S:W487 S:S:Y466 87.17257.72YesYes069
36S:S:L492 S:S:W487 85.73896.83YesYes056
37S:S:L492 S:S:R208 73.05463.64YesYes2355
38S:S:R208 S:S:Y209 72.74245.14YesNo2358
39S:S:W211 S:S:Y209 72.603817.36NoNo098
40S:S:F165 S:S:L164 57.743.65YesNo1875
41S:S:F165 S:S:L161 42.4884.87YesNo075
42S:S:L106 S:S:L161 27.20432.77NoNo055
43R:R:L164 S:S:L106 27.04194.15NoNo1855
44R:R:G148 R:R:Y172 18.7872.9NoYes087
45R:R:G148 R:R:P149 18.83424.06NoYes086
46R:R:L40 R:R:P149 18.50694.93NoYes066
47R:R:F112 R:R:L40 18.54343.65YesNo066
48R:R:F112 R:R:R96 17.61579.62YesYes1264
49R:R:E111 R:R:R96 29.980312.79NoYes034
50R:R:E111 S:S:R114 29.96110.47NoNo037
51R:R:R114 S:S:R114 29.95153.2NoNo077
52R:R:R114 S:S:E111 29.96149.3NoNo073
53S:S:E111 S:S:R96 29.98112.79NoYes034
54R:R:R55 R:R:V104 29.915924.84YesNo023
55R:R:I110 S:S:F165 15.84096.28YesYes1857
56R:R:I110 S:S:L117 29.52052.85YesNo054
57R:R:E107 S:S:L117 29.36619.28NoNo054
58R:R:E107 R:R:R55 27.777122.1NoYes1252
59R:R:N352 R:R:W354 14.494321.47YesYes175
60R:R:M31 R:R:P32 10.43643.35YesNo053
61R:R:H30 R:R:P32 10.47814.58NoNo043
62R:R:E94 R:R:K141 11.351414.85YesYes1254
63R:R:V43 R:R:W354 26.655812.26NoYes155
64R:R:H44 R:R:V43 13.56365.54YesNo175
65R:R:D97 R:R:V43 13.295213.15NoNo195
66R:R:C99 R:R:H44 13.5012.95YesYes177
67R:R:C99 R:R:D97 13.35339.34YesNo179
68R:R:C99 R:R:V104 27.17295.12YesNo073
69R:R:I110 S:S:I110 33.19662.94YesYes1855
70S:S:I110 S:S:L161 15.53732.85YesNo055
71R:R:L117 S:S:I110 37.17042.85NoYes045
72R:R:L117 S:S:E107 37.02399.28NoNo045
73R:R:I506 R:R:W500 80.37467.05NoNo047
74R:R:I506 R:R:R272 80.204711.27NoNo045
75R:R:E298 R:R:R272 79.864312.79NoNo035
76R:R:E298 R:R:F299 79.27873.5NoYes437
77R:R:F299 R:R:L264 75.36893.65YesNo477
78R:R:L264 R:R:S215 74.98346.01NoNo478
79R:R:H267 R:R:S215 74.84188.37YesNo438
80R:R:H267 R:R:Y213 74.279119.6YesYes439
81R:R:C511 R:R:Y213 72.22725.38NoYes499
82R:R:F355 R:R:P346 11.52747.22YesYes146
83R:R:C511 R:R:S512 71.8381.72NoNo498
84R:R:S512 R:R:W532 71.92037.41NoNo488
85R:R:W532 R:R:Y547 71.103911.58NoNo483
86R:R:E546 R:R:Y547 71.02026.73NoNo073
87R:R:E546 R:R:K521 70.47782.7NoNo078
88R:R:K521 R:R:V543 69.38799.11NoNo087
89R:R:L562 R:R:V543 69.20565.96NoNo067
90R:R:L562 R:R:P558 67.18733.28NoNo068
91R:R:C552 R:R:P558 65.33225.65YesNo098
92R:R:C552 R:R:N540 64.7724.72YesYes2298
93R:R:N540 R:R:W557 63.83432.26YesNo087
94R:R:I568 R:R:W557 63.26954.7NoNo087
95R:R:I568 R:R:V729 62.89199.22NoYes087
96R:R:H721 R:R:V729 61.86244.15NoYes4127
97R:R:H721 R:R:V570 61.75476.92NoNo024
98R:R:L731 R:R:V570 61.564413.41NoNo064
99R:R:L731 R:R:P639 61.18349.85NoNo069
100R:R:P639 R:R:Y643 60.03589.74NoYes097
101R:R:Q647 R:R:Y643 58.99629.02YesYes1087
102R:R:L635 R:R:Q647 58.68817.99YesYes1078
103R:R:L635 R:R:M802 10.72838.48YesYes1078
104R:R:C803 R:R:L635 11.05584.76YesYes077
105R:R:I651 R:R:L635 38.66685.71YesYes1077
106R:R:C631 R:R:I651 35.14623.27NoYes077
107R:R:C631 R:R:G628 34.7193.92NoNo076
108R:R:G628 R:R:S654 34.2913.71NoNo067
109R:R:P655 R:R:S654 34.07673.56NoNo087
110R:R:P655 R:R:W785 33.86235.4NoYes088
111R:R:I751 R:R:W785 28.17083.52YesYes2588
112R:R:I751 R:R:M778 27.34162.92YesNo2589
113R:R:C754 R:R:M778 27.32751.62NoNo089
114R:R:C754 R:R:V663 27.10723.42NoNo087
115R:R:T664 R:R:V663 26.4451.59NoNo067
116R:R:A697 R:R:T664 25.11555.03NoNo076
117R:R:A661 R:R:A697 24.89331.79NoNo077
118R:R:A661 R:R:L617 15.82893.15NoYes078
119R:R:K665 R:R:L617 14.00582.82NoYes898
120R:R:E770 R:R:K665 13.78429.45YesNo899
121R:R:K821 R:R:Y773 10.3195.97YesYes895
122S:S:E107 S:S:R55 35.397622.1NoYes1352
123S:S:R55 S:S:V104 38.226524.84YesNo023
124S:S:C99 S:S:V104 35.12236.83YesNo073
125S:S:C99 S:S:H44 17.46332.95YesYes377
126S:S:H44 S:S:V43 17.47895.54YesNo375
127S:S:V43 S:S:W354 34.489212.26NoYes355
128S:S:C99 S:S:D97 17.30879.34YesNo379
129S:S:D97 S:S:V43 17.235413.15NoNo395
130S:S:F112 S:S:R96 18.56549.62YesYes1364
131S:S:F112 S:S:L40 19.42773.65YesNo066
132S:S:L40 S:S:P149 19.38674.93NoYes066
133S:S:G148 S:S:P149 19.81774.06NoYes086
134S:S:G148 S:S:Y172 19.76642.9NoYes087
135S:S:N352 S:S:W354 19.633221.47YesYes375
136S:S:F399 S:S:K396 23.45523.72NoNo074
137S:S:I66 S:S:W354 14.11775.87YesYes365
138S:S:F355 S:S:N352 12.47553.62YesYes347
139S:S:S173 S:S:Y172 20.94395.09NoYes057
140S:S:V273 S:S:W211 71.91078.58NoNo089
141S:S:S509 S:S:V273 71.56993.23NoNo098
142S:S:R272 S:S:S509 71.23523.95YesNo059
143S:S:E298 S:S:R272 72.273511.63NoYes035
144S:S:E298 S:S:F299 71.67983.5NoYes637
145S:S:F299 S:S:L264 64.91247.31YesNo677
146S:S:L264 S:S:S215 64.51596.01NoNo678
147S:S:H267 S:S:S215 64.36118.37YesNo638
148S:S:H267 S:S:Y213 63.779320.69YesYes639
149S:S:C530 S:S:Y213 62.61214.03YesYes699
150S:S:F355 S:S:P346 21.23357.22YesYes346
151S:S:F370 S:S:P346 10.48911.56YesYes026
152S:S:C530 S:S:W532 61.92433.92YesNo098
153S:S:V522 S:S:W532 61.5519.81YesNo058
154S:S:K521 S:S:V522 58.34673.04NoYes085
155S:S:K521 S:S:V543 56.88497.59NoNo087
156S:S:L562 S:S:V543 56.69355.96NoNo067
157S:S:L562 S:S:P558 56.43593.28NoYes068
158S:S:P558 S:S:W557 53.72841.35YesNo087
159S:S:I568 S:S:W557 53.53354.7NoNo087
160S:S:I568 S:S:V729 53.14339.22NoYes087
161S:S:H721 S:S:V729 52.09564.15NoYes5427
162S:S:H721 S:S:V570 51.96796.92NoNo024
163S:S:L731 S:S:V570 51.771413.41NoNo064
164S:S:L731 S:S:P639 51.18059.85NoNo069
165S:S:P639 S:S:Y643 48.99929.74NoYes097
166S:S:Q647 S:S:Y643 44.641710.15YesYes787
167S:S:L635 S:S:Q647 41.46511.98YesYes778
168S:S:C803 S:S:L635 23.78433.17YesYes077
169S:S:C803 S:S:T632 21.78748.45YesNo077
170S:S:S807 S:S:T632 21.34163.2NoNo087
171S:S:F586 S:S:S807 21.11845.28NoNo038
172S:S:F586 S:S:T811 20.671410.38NoNo036
173S:S:T811 S:S:Y629 20.44766.24NoYes068
174S:S:T594 S:S:Y629 16.61362.5NoYes078
175S:S:L622 S:S:T594 16.38634.42NoNo097
176S:S:F601 S:S:L622 16.15892.44NoNo089
177S:S:F601 S:S:V597 15.24712.62NoNo086
178S:S:L814 S:S:V597 15.01872.98YesNo086
179S:S:F818 S:S:L814 14.10313.65YesYes088
180S:S:F818 S:S:M817 11.09166.22YesYes088
181S:S:I651 S:S:L635 11.41854.28NoYes777
182S:S:C631 S:S:I651 11.33793.27NoNo077
183S:S:C631 S:S:G628 10.87433.92NoNo076
184S:S:G628 S:S:S654 10.413.71NoNo067
185S:S:P655 S:S:S654 10.17753.56NoNo087
186R:R:H30 R:R:K141 10.523110.48NoYes044
187R:R:E94 R:R:R96 11.436416.28YesYes1254
188S:S:K396 S:S:S173 20.82024.59NoNo045
189R:R:I110 R:R:L161 11.74332.85YesNo055
190R:R:F165 S:S:I110 12.05276.28YesYes1875
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 6N52
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu5; mGlu5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 4
Date 2019-01-23
D.O.I. 10.1038/s41586-019-0881-4
Net Summary
Imin 2.73
Number of Linked Nodes 1453
Number of Links 1712
Number of Hubs 251
Number of Links mediated by Hubs 904
Number of Communities 57
Number of Nodes involved in Communities 437
Number of Links involved in Communities 598
Path Summary
Number Of Nodes in MetaPath 191
Number Of Links MetaPath 190
Number of Shortest Paths 2189852
Length Of Smallest Path 3
Average Path Length 49.8856
Length of Longest Path 137
Minimum Path Strength 1.25
Average Path Strength 6.83174
Maximum Path Strength 28.99
Minimum Path Correlation 0.7
Average Path Correlation 0.996895
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 59.8234
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3917
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein tyrosine kinase activator activity   • enzyme regulator activity   • catalytic activity, acting on a protein   • molecular function activator activity   • kinase activity   • protein kinase activity   • transferase activity   • protein kinase regulator activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • kinase activator activity   • enzyme activator activity   • protein tyrosine kinase activity   • molecular function regulator activity   • catalytic activity   • protein kinase activator activity   • kinase regulator activity   • glutamate receptor activity   • G protein-coupled glutamate receptor activity   • molecular transducer activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • protein binding   • binding   • A2A adenosine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • adenosine receptor binding   • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration   • neurotransmitter receptor activity   • postsynaptic neurotransmitter receptor activity   • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential   • protein tyrosine kinase binding   • kinase binding   • enzyme binding   • protein kinase binding   • identical protein binding   • behavior   • multicellular organismal process   • locomotory behavior   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus
Gene OntologyBiological Process• behavior   • multicellular organismal process   • locomotory behavior   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • regulation of cell communication   • cellular process   • positive regulation of signaling   • system process   • learning   • learning or memory   • nervous system process   • cognition   • negative adaptation of signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • desensitization of G protein-coupled receptor signaling pathway   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • negative regulation of response to stimulus   • negative regulation of signal transduction   • adaptation of signaling pathway   • G protein-coupled receptor signaling pathway   • cellular component organization   • cell junction organization   • synapse organization   • cellular component organization or biogenesis   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • primary metabolic process   • regulation of macromolecule metabolic process   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of gene expression   • biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • regulation of DNA-templated transcription   • macromolecule metabolic process   • regulation of metabolic process   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • cell-cell signaling   • chemical synaptic transmission   • cell surface receptor signaling pathway   • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of nervous system development   • regulation of long-term neuronal synaptic plasticity   • regulation of developmental process   • cellular developmental process   • modulation of chemical synaptic transmission   • cell development   • regulation of cell differentiation   • regulation of neurogenesis   • regulation of cell development   • regulation of nervous system development   • positive regulation of developmental process   • multicellular organism development   • neurogenesis   • positive regulation of cell differentiation   • cell differentiation   • anatomical structure development   • positive regulation of long-term neuronal synaptic plasticity   • positive regulation of neurogenesis   • regulation of multicellular organismal process   • regulation of biological quality   • system development   • regulation of neuronal synaptic plasticity   • regulation of synaptic plasticity   • developmental process   • regulation of multicellular organismal development   • positive regulation of cell development   • nervous system development   • regulation of trans-synaptic signaling   • positive regulation of multicellular organismal process   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • cellular response to nitrogen compound   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to amyloid-beta   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to amyloid-beta   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction
Gene OntologyCellular Component• postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction   • postsynaptic membrane   • asymmetric synapse   • plasma membrane region   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • intracellular anatomical structure   • cytoplasm   • glutamatergic synapse   • dendritic shaft   • neuron spine   • dendritic spine   • Schaffer collateral - CA1 synapse   • cell body   • neuronal cell body
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • G protein-coupled receptor-like
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41594
Sequence
>6N52_Chain_R
RVVAHMPGD IIIGALFSV HHQPTVDKV HERKCGAVR EQYGIQRVE 
AMLHTLERI NSDPTLLPN ITLGCEIRD SCWHSAVAL EQSIEFIRD 
SLISSEESF RSKKPIVGV IGPGSSSVA IQVQNLLQL FNIPQIAYS 
ATSMDLSDK TLFKYFMRV VPSDAQQAR AMVDIVKRY NWTYVSAVH 
TEGNYGESG MEAFKDMSA KEGICIAHS YKIYSNAGE QSFDKLLKK 
LTSHLPKAR VVACFCEGM TVRGLLMAM RRLGLAGEF LLLGSDGWA 
DRYDVTDGY QREAVGGIT IKLQSPDVK WFDDYYLKL RPETNHRNP 
WFQEFWQHR FQCRLEGFP QENSKYNKT CNSSLTLKT HHVQDSKMG 
FVINAIYSM AYGLHNMQM SLCPGYAGL CDAMKPIDG RKLLESLMK 
TNFTGVSGD TILFDENGD SPGRYEIMN FKEMGKDYF DYINVGSWD 
NGELKMDDD EVWSKKSNI IRSVCSEPC EKGQIKVIR KGEVSCCWT 
CTPCKENEY VFDEYTCKA CQLGSWPTD DLTGCDLIP VQYLRWGDP 
EPIAAVVFA CLGLLATLF VTVVFIIYR DTPVVKSSS RELCYIILA 
GICLGYLCT FCLIAKPKQ IYCYLQRIG IGLSPAMSY SALVTKTNR 
IACAQLVIA FILICIQLG IIVALFIME PPDIMHDYP SIREVYLIC 
NTTNLGVVT PLGYNGLLI LSCTFYAFK TRNVPANFN EAKYIAFTM 
YTTCIIWLA FVPIYFGSN YKIITMCFS VSLSATVAL GCMFVPKVY 
IILAKPERN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41594
Sequence
>6N52_Chain_S
RVVAHMPGD IIIGALFSV HHQPTVDKV HERKCGAVR EQYGIQRVE 
AMLHTLERI NSDPTLLPN ITLGCEIRD SCWHSAVAL EQSIEFIRD 
SLISSEESF RSKKPIVGV IGPGSSSVA IQVQNLLQL FNIPQIAYS 
ATSMDLSDK TLFKYFMRV VPSDAQQAR AMVDIVKRY NWTYVSAVH 
TEGNYGESG MEAFKDMSA KEGICIAHS YKIYSNAGE QSFDKLLKK 
LTSHLPKAR VVACFCEGM TVRGLLMAM RRLGLAGEF LLLGSDGWA 
DRYDVTDGY QREAVGGIT IKLQSPDVK WFDDYYLKL RPETNHRNP 
WFQEFWQHR FQCRLEGFP QENSKYNKT CNSSLTLKT HHVQDSKMG 
FVINAIYSM AYGLHNMQM SLCPGYAGL CDAMKPIDG RKLLESLMK 
TNFTGVSGD TILFDENGD SPGRYEIMN FKEMGKDYF DYINVGSWD 
NGELKMDDD EVWSKKSNI IRSVCSEPC EKGQIKVIR KGEVSCCWT 
CTPCKENEY VFDEYTCKA CQLGSWPTD DLTGCDLIP VQYLRWGDP 
EPIAAVVFA CLGLLATLF VTVVFIIYR DTPVVKSSS RELCYIILA 
GICLGYLCT FCLIAKPKQ IYCYLQRIG IGLSPAMSY SALVTKTNR 
IACAQLVIA FILICIQLG IIVALFIME PPDIMHDYP SIREVYLIC 
NTTNLGVVT PLGYNGLLI LSCTFYAFK TRNVPANFN EAKYIAFTM 
YTTCIIWLA FVPIYFGSN YKIITMCFS VSLSATVAL GCMFVPKVY 
IILAKPERN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X0HCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--4.12024-11-06doi.org/10.1038/s41467-024-55439-9
8X0GCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--32024-11-06doi.org/10.1038/s41467-024-55439-9
8X0FCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.32024-11-06doi.org/10.1038/s41467-024-55439-9
8X0ECAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.42024-11-06doi.org/10.1038/s41467-024-55439-9
8X0DCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.52024-11-06doi.org/10.1038/s41467-024-55439-9
8X0CCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.22024-11-06doi.org/10.1038/s41467-024-55439-9
8X0BCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.12024-11-06doi.org/10.1038/s41467-024-55439-9
8TAOCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateCDPPB-2.92023-10-1110.1101/2023.08.29.555158
8T8MCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--32023-10-1110.1101/2023.08.29.555158
8T7HCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.32023-10-1110.1101/2023.08.29.555158
8T6JCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiens-CDPPB-3.52023-10-1110.1101/2023.08.29.555158
7P2LCAminoacidMetabotropic GlutamatemGlu5Homo sapiens-4YI-2.542021-09-0810.1016/j.celrep.2021.109648
7FD9CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensLY341495--42021-09-0810.1016/j.celrep.2021.109648
7FD8CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.82021-09-0810.1016/j.celrep.2021.109648
6N52CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiens---42019-01-2310.1038/s41586-019-0881-4
6N51CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--42019-01-2310.1038/s41586-019-0881-4
6FFICAminoacidMetabotropic GlutamatemGlu5Homo sapiens-MMPEP-2.22018-03-0710.1021/acs.jmedchem.7b01722
6FFHCAminoacidMetabotropic GlutamatemGlu5Homo sapiens-Fenobam-2.652018-03-0710.1021/acs.jmedchem.7b01722
5CGDCAminoacidMetabotropic GlutamatemGlu5Homo sapiens-HTL14242-2.62015-08-1210.1021/acs.jmedchem.5b00892
5CGCCAminoacidMetabotropic GlutamatemGlu5Homo sapiens-HTL14242-3.12015-08-1210.1021/acs.jmedchem.5b00892
4OO9CAminoacidMetabotropic GlutamatemGlu5Homo sapiens-Mavoglurant-2.62014-07-0210.1038/nature13396




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6N52.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.