| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T6J | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | - | CDPPB | - | 3.5 | 2023-10-11 | 10.1101/2023.08.29.555158 |
|
A 2D representation of the interactions of YKU in 8T6J
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:G628 | S:S:S654 | 3.71 | 0 | No | No | 6 | 7 | 2 | 1 | | S:S:G628 | S:S:V806 | 1.84 | 0 | No | No | 6 | 8 | 2 | 1 | | S:S:A810 | S:S:Y629 | 5.34 | 0 | No | Yes | 7 | 8 | 1 | 2 | | S:S:G652 | S:S:P655 | 4.06 | 0 | No | Yes | 5 | 8 | 2 | 1 | | S:S:P655 | S:S:S654 | 3.56 | 25 | Yes | No | 8 | 7 | 1 | 1 | | S:S:S654 | X:X:?1 | 5.64 | 25 | No | Yes | 7 | 0 | 1 | 0 | | S:S:N747 | S:S:P655 | 6.52 | 0 | No | Yes | 7 | 8 | 2 | 1 | | S:S:P655 | X:X:?1 | 13.57 | 25 | Yes | Yes | 8 | 0 | 1 | 0 | | S:S:S658 | S:S:Y659 | 2.54 | 0 | No | Yes | 6 | 7 | 2 | 1 | | S:S:L750 | S:S:Y659 | 2.34 | 0 | No | Yes | 9 | 7 | 2 | 1 | | S:S:I751 | S:S:Y659 | 4.84 | 25 | No | Yes | 8 | 7 | 1 | 1 | | S:S:Y659 | X:X:?1 | 2.64 | 25 | Yes | Yes | 7 | 0 | 1 | 0 | | S:S:L744 | X:X:?1 | 8.32 | 0 | No | Yes | 8 | 0 | 1 | 0 | | S:S:G748 | S:S:I751 | 1.76 | 25 | No | No | 5 | 8 | 1 | 1 | | S:S:G748 | X:X:?1 | 5.14 | 25 | No | Yes | 5 | 0 | 1 | 0 | | S:S:I751 | X:X:?1 | 4.29 | 25 | No | Yes | 8 | 0 | 1 | 0 | | S:S:L752 | X:X:?1 | 2.08 | 0 | No | Yes | 3 | 0 | 1 | 0 | | S:S:S805 | X:X:?1 | 5.64 | 0 | No | Yes | 8 | 0 | 1 | 0 | | S:S:V806 | X:X:?1 | 5.6 | 0 | No | Yes | 8 | 0 | 1 | 0 | | S:S:S809 | X:X:?1 | 13.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | | S:S:A810 | X:X:?1 | 3.55 | 0 | No | Yes | 7 | 0 | 1 | 0 | | S:S:G745 | S:S:L744 | 1.71 | 0 | No | No | 5 | 8 | 2 | 1 | | S:S:A813 | X:X:?1 | 1.18 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 12.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 5.93 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of YKU in 8T6J
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G628 | R:R:S654 | 3.71 | 0 | No | No | 6 | 7 | 2 | 1 | | R:R:G628 | R:R:V806 | 1.84 | 0 | No | No | 6 | 8 | 2 | 1 | | R:R:A810 | R:R:Y629 | 4 | 0 | No | Yes | 7 | 8 | 1 | 2 | | R:R:G652 | R:R:P655 | 4.06 | 0 | No | Yes | 5 | 8 | 2 | 1 | | R:R:P655 | R:R:S654 | 3.56 | 14 | Yes | No | 8 | 7 | 1 | 1 | | R:R:S654 | W:W:?1 | 5.64 | 14 | No | Yes | 7 | 0 | 1 | 0 | | R:R:N747 | R:R:P655 | 6.52 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:P655 | W:W:?1 | 12.34 | 14 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:S658 | R:R:Y659 | 3.82 | 0 | No | Yes | 6 | 7 | 2 | 1 | | R:R:L750 | R:R:Y659 | 2.34 | 0 | No | Yes | 9 | 7 | 2 | 1 | | R:R:I751 | R:R:Y659 | 6.04 | 14 | No | Yes | 8 | 7 | 1 | 1 | | R:R:Y659 | W:W:?1 | 1.76 | 14 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:L744 | W:W:?1 | 8.32 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:G748 | R:R:I751 | 1.76 | 14 | No | No | 5 | 8 | 1 | 1 | | R:R:G748 | W:W:?1 | 5.14 | 14 | No | Yes | 5 | 0 | 1 | 0 | | R:R:I751 | W:W:?1 | 4.29 | 14 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L752 | R:R:T755 | 2.95 | 14 | No | No | 3 | 8 | 1 | 2 | | R:R:F756 | R:R:L752 | 2.44 | 14 | No | No | 4 | 3 | 2 | 1 | | R:R:L752 | W:W:?1 | 2.08 | 14 | No | Yes | 3 | 0 | 1 | 0 | | R:R:F756 | R:R:T755 | 3.89 | 14 | No | No | 4 | 8 | 2 | 2 | | R:R:S805 | W:W:?1 | 5.64 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:V806 | W:W:?1 | 5.6 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:S809 | W:W:?1 | 13.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:A810 | W:W:?1 | 2.37 | 0 | No | Yes | 7 | 0 | 1 | 0 | | R:R:G745 | R:R:L744 | 1.71 | 0 | No | No | 5 | 8 | 2 | 1 | | R:R:A813 | W:W:?1 | 1.18 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 12.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 5.66 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8TAO | C | Aminoacid | Metabotropic Glutamate | mGlu5; mGlu5 | Homo Sapiens | Quisqualate | CDPPB | - | 2.9 | 2023-10-11 | 10.1101/2023.08.29.555158 |
|
A 2D representation of the interactions of YKU in 8TAO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:I625 | S:S:T594 | 4.56 | 4 | Yes | No | 8 | 7 | 1 | 2 | | S:S:L814 | S:S:T594 | 4.42 | 4 | Yes | No | 8 | 7 | 2 | 2 | | S:S:I625 | S:S:Y629 | 3.63 | 4 | Yes | Yes | 8 | 8 | 1 | 2 | | S:S:A810 | S:S:I625 | 3.25 | 4 | No | Yes | 7 | 8 | 1 | 1 | | S:S:I625 | S:S:L814 | 17.13 | 4 | Yes | Yes | 8 | 8 | 1 | 2 | | S:S:I625 | X:X:?1 | 3.22 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | S:S:A810 | S:S:Y629 | 6.67 | 4 | No | Yes | 7 | 8 | 1 | 2 | | S:S:L814 | S:S:Y629 | 4.69 | 4 | Yes | Yes | 8 | 8 | 2 | 2 | | S:S:P655 | S:S:S654 | 3.56 | 0 | No | No | 8 | 7 | 1 | 2 | | S:S:P655 | X:X:?1 | 19.74 | 0 | No | Yes | 8 | 0 | 1 | 0 | | S:S:T781 | S:S:Y659 | 6.24 | 4 | No | No | 9 | 7 | 1 | 1 | | S:S:Y659 | X:X:?1 | 4.4 | 4 | No | Yes | 7 | 0 | 1 | 0 | | S:S:L744 | S:S:W785 | 4.56 | 4 | No | Yes | 8 | 8 | 1 | 1 | | S:S:L744 | X:X:?1 | 7.28 | 4 | No | Yes | 8 | 0 | 1 | 0 | | S:S:N747 | X:X:?1 | 3.09 | 0 | No | Yes | 7 | 0 | 1 | 0 | | S:S:I751 | S:S:M778 | 5.83 | 0 | Yes | No | 8 | 9 | 1 | 2 | | S:S:I751 | X:X:?1 | 8.58 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | | S:S:T781 | X:X:?1 | 8.86 | 4 | No | Yes | 9 | 0 | 1 | 0 | | S:S:I784 | S:S:S809 | 4.64 | 0 | No | No | 8 | 9 | 2 | 1 | | S:S:F788 | S:S:W785 | 8.02 | 4 | Yes | Yes | 9 | 8 | 1 | 1 | | S:S:V789 | S:S:W785 | 11.03 | 4 | No | Yes | 7 | 8 | 2 | 1 | | S:S:W785 | S:S:Y792 | 2.89 | 4 | Yes | Yes | 8 | 8 | 1 | 2 | | S:S:W785 | X:X:?1 | 25.67 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | S:S:F788 | S:S:Y792 | 23.73 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | | S:S:F788 | S:S:T801 | 3.89 | 4 | Yes | No | 9 | 8 | 1 | 2 | | S:S:F788 | S:S:S805 | 5.28 | 4 | Yes | No | 9 | 8 | 1 | 1 | | S:S:F788 | X:X:?1 | 7.32 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | | S:S:V789 | S:S:Y792 | 3.79 | 4 | No | Yes | 7 | 8 | 2 | 2 | | S:S:S805 | X:X:?1 | 6.77 | 4 | No | Yes | 8 | 0 | 1 | 0 | | S:S:V806 | X:X:?1 | 6.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | | S:S:S809 | X:X:?1 | 15.79 | 0 | No | Yes | 9 | 0 | 1 | 0 | | S:S:A810 | X:X:?1 | 3.55 | 4 | No | Yes | 7 | 0 | 1 | 0 | | S:S:F788 | S:S:M802 | 2.49 | 4 | Yes | No | 9 | 8 | 1 | 2 | | S:S:L750 | S:S:Y659 | 2.34 | 0 | No | No | 9 | 7 | 2 | 1 | | S:S:G748 | S:S:I751 | 1.76 | 0 | No | Yes | 5 | 8 | 2 | 1 | | S:S:I751 | S:S:L752 | 1.43 | 0 | Yes | No | 8 | 3 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 13.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 9.31 | | Average Nodes In Shell | 27.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 36.00 | | Average Links Mediated by Hubs In Shell | 32.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
