Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8T6J | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | - | CDPPB | - | 3.5 | 2023-10-11 | 10.1101/2023.08.29.555158 |
![](/psngpcr/ligands/YKU/YKU_8T6J_X_X_1.png)
A 2D representation of the interactions of YKU in 8T6J colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:G628 | S:S:S654 | 3.71 | 0 | No | No | 6 | 7 | 2 | 1 | S:S:G628 | S:S:V806 | 1.84 | 0 | No | No | 6 | 8 | 2 | 1 | S:S:A810 | S:S:Y629 | 5.34 | 0 | No | Yes | 7 | 8 | 1 | 2 | S:S:G652 | S:S:P655 | 4.06 | 0 | No | Yes | 5 | 8 | 2 | 1 | S:S:P655 | S:S:S654 | 3.56 | 2 | Yes | No | 8 | 7 | 1 | 1 | S:S:S654 | X:X:?1 | 4.25 | 2 | No | Yes | 7 | 0 | 1 | 0 | S:S:N747 | S:S:P655 | 6.52 | 0 | No | Yes | 7 | 8 | 2 | 1 | S:S:P655 | X:X:?1 | 10.24 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:P655 | W:W:?1 | 3.72 | 2 | Yes | Yes | 8 | 0 | 1 | 1 | S:S:S658 | S:S:Y659 | 2.54 | 0 | No | Yes | 6 | 7 | 2 | 1 | S:S:L750 | S:S:Y659 | 2.34 | 0 | No | Yes | 9 | 7 | 2 | 1 | S:S:I751 | S:S:Y659 | 4.84 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | S:S:T781 | S:S:Y659 | 3.75 | 2 | No | Yes | 9 | 7 | 2 | 1 | S:S:Y659 | X:X:?1 | 1.99 | 2 | Yes | Yes | 7 | 0 | 1 | 0 | S:S:L744 | X:X:?1 | 6.27 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:G748 | S:S:I751 | 1.76 | 2 | No | Yes | 5 | 8 | 1 | 1 | S:S:G748 | X:X:?1 | 3.88 | 2 | No | Yes | 5 | 0 | 1 | 0 | S:S:I751 | S:S:T781 | 4.56 | 2 | Yes | No | 8 | 9 | 1 | 2 | S:S:I751 | S:S:W785 | 3.52 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | S:S:I751 | X:X:?1 | 3.24 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:S809 | S:S:T781 | 3.2 | 0 | No | No | 9 | 9 | 1 | 2 | S:S:C782 | S:S:W785 | 15.67 | 0 | No | Yes | 6 | 8 | 2 | 1 | S:S:I784 | S:S:S809 | 3.1 | 0 | No | No | 8 | 9 | 2 | 1 | S:S:L786 | S:S:W785 | 31.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | S:S:W785 | X:X:?1 | 28.4 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:W785 | W:W:?1 | 4.52 | 2 | Yes | Yes | 8 | 0 | 1 | 1 | S:S:F788 | S:S:Y792 | 15.47 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:F788 | S:S:T801 | 2.59 | 2 | Yes | No | 9 | 8 | 1 | 2 | S:S:F788 | S:S:M802 | 6.22 | 2 | Yes | No | 9 | 8 | 1 | 2 | S:S:F788 | S:S:S805 | 9.25 | 2 | Yes | No | 9 | 8 | 1 | 1 | S:S:F788 | X:X:?1 | 8.28 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:M802 | S:S:Y792 | 3.59 | 2 | No | Yes | 8 | 8 | 2 | 2 | S:S:S805 | X:X:?1 | 4.25 | 2 | No | Yes | 8 | 0 | 1 | 0 | S:S:V806 | X:X:?1 | 4.22 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:S809 | X:X:?1 | 10.21 | 0 | No | Yes | 9 | 0 | 1 | 0 | S:S:A810 | X:X:?1 | 2.68 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:P655 | R:R:S654 | 3.56 | 2 | Yes | No | 8 | 7 | 2 | 2 | R:R:S654 | W:W:?1 | 4.25 | 2 | No | Yes | 7 | 0 | 2 | 1 | R:R:P655 | W:W:?1 | 9.31 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | R:R:L744 | W:W:?1 | 6.27 | 0 | No | Yes | 8 | 0 | 2 | 1 | R:R:G748 | R:R:I751 | 1.76 | 2 | No | Yes | 5 | 8 | 2 | 2 | R:R:G748 | W:W:?1 | 3.88 | 2 | No | Yes | 5 | 0 | 2 | 1 | R:R:I751 | R:R:W785 | 3.52 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:I751 | W:W:?1 | 3.24 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | R:R:W785 | W:W:?1 | 25.17 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | R:R:F788 | R:R:S805 | 9.25 | 2 | Yes | No | 9 | 8 | 2 | 2 | R:R:F788 | W:W:?1 | 8.28 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | R:R:S805 | W:W:?1 | 4.25 | 2 | No | Yes | 8 | 0 | 2 | 1 | R:R:V806 | W:W:?1 | 4.22 | 0 | No | Yes | 8 | 0 | 2 | 1 | R:R:S809 | W:W:?1 | 10.21 | 0 | No | Yes | 9 | 0 | 2 | 1 | R:R:A810 | W:W:?1 | 1.79 | 0 | No | Yes | 7 | 0 | 2 | 1 | W:W:?1 | X:X:?1 | 22.22 | 2 | Yes | Yes | 0 | 0 | 1 | 0 | S:S:G745 | S:S:L744 | 1.71 | 0 | No | No | 5 | 8 | 2 | 1 | S:S:L752 | X:X:?1 | 1.57 | 2 | No | Yes | 3 | 0 | 1 | 0 | S:S:L752 | W:W:?1 | 1.57 | 2 | No | Yes | 3 | 0 | 1 | 1 | R:R:L752 | W:W:?1 | 1.57 | 0 | No | Yes | 3 | 0 | 2 | 1 | S:S:A813 | X:X:?1 | 0.89 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:A813 | W:W:?1 | 0.89 | 0 | No | Yes | 7 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.51 | Average Nodes In Shell | 43.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 58.00 | Average Links Mediated by Hubs In Shell | 53.00 |
| ![](/psngpcr/ligands/YKU/YKU_8T6J_X_X_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YKU/YKU_8T6J_X_X_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YKU/YKU_8T6J_W_W_1.png)
A 2D representation of the interactions of YKU in 8T6J colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:G652 | S:S:P655 | 4.06 | 0 | No | Yes | 5 | 8 | 2 | 1 | S:S:P655 | S:S:S654 | 3.56 | 2 | Yes | No | 8 | 7 | 1 | 2 | S:S:S654 | X:X:?1 | 4.25 | 2 | No | Yes | 7 | 0 | 2 | 1 | S:S:N747 | S:S:P655 | 6.52 | 0 | No | Yes | 7 | 8 | 2 | 1 | S:S:P655 | X:X:?1 | 10.24 | 2 | Yes | Yes | 8 | 0 | 1 | 1 | S:S:P655 | W:W:?1 | 3.72 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:I751 | S:S:Y659 | 4.84 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:Y659 | X:X:?1 | 1.99 | 2 | Yes | Yes | 7 | 0 | 2 | 1 | S:S:L744 | X:X:?1 | 6.27 | 0 | No | Yes | 8 | 0 | 2 | 1 | S:S:G748 | S:S:I751 | 1.76 | 2 | No | Yes | 5 | 8 | 2 | 2 | S:S:G748 | X:X:?1 | 3.88 | 2 | No | Yes | 5 | 0 | 2 | 1 | S:S:I751 | S:S:W785 | 3.52 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | S:S:I751 | X:X:?1 | 3.24 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | S:S:C782 | S:S:W785 | 15.67 | 0 | No | Yes | 6 | 8 | 2 | 1 | S:S:L786 | S:S:W785 | 31.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | S:S:W785 | X:X:?1 | 28.4 | 2 | Yes | Yes | 8 | 0 | 1 | 1 | S:S:W785 | W:W:?1 | 4.52 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:F788 | S:S:S805 | 9.25 | 2 | Yes | No | 9 | 8 | 2 | 2 | S:S:F788 | X:X:?1 | 8.28 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | S:S:S805 | X:X:?1 | 4.25 | 2 | No | Yes | 8 | 0 | 2 | 1 | S:S:V806 | X:X:?1 | 4.22 | 0 | No | Yes | 8 | 0 | 2 | 1 | S:S:S809 | X:X:?1 | 10.21 | 0 | No | Yes | 9 | 0 | 2 | 1 | S:S:A810 | X:X:?1 | 2.68 | 0 | No | Yes | 7 | 0 | 2 | 1 | R:R:G628 | R:R:S654 | 3.71 | 0 | No | No | 6 | 7 | 2 | 1 | R:R:G628 | R:R:V806 | 1.84 | 0 | No | No | 6 | 8 | 2 | 1 | R:R:A810 | R:R:Y629 | 4 | 0 | No | Yes | 7 | 8 | 1 | 2 | R:R:G652 | R:R:P655 | 4.06 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:P655 | R:R:S654 | 3.56 | 2 | Yes | No | 8 | 7 | 1 | 1 | R:R:S654 | W:W:?1 | 4.25 | 2 | No | Yes | 7 | 0 | 1 | 0 | R:R:N747 | R:R:P655 | 6.52 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:P655 | W:W:?1 | 9.31 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:I751 | R:R:Y659 | 6.04 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:T781 | R:R:Y659 | 3.75 | 2 | Yes | Yes | 9 | 7 | 2 | 2 | R:R:L744 | W:W:?1 | 6.27 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:G748 | R:R:I751 | 1.76 | 2 | No | Yes | 5 | 8 | 1 | 1 | R:R:G748 | W:W:?1 | 3.88 | 2 | No | Yes | 5 | 0 | 1 | 0 | R:R:I751 | R:R:T781 | 4.56 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:I751 | R:R:W785 | 3.52 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | R:R:I751 | W:W:?1 | 3.24 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:L752 | R:R:T755 | 2.95 | 0 | No | No | 3 | 8 | 1 | 2 | R:R:S809 | R:R:T781 | 3.2 | 0 | No | Yes | 9 | 9 | 1 | 2 | R:R:C782 | R:R:W785 | 15.67 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:L786 | R:R:W785 | 31.89 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:W785 | W:W:?1 | 25.17 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:F788 | R:R:Y792 | 15.47 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:F788 | R:R:M802 | 6.22 | 2 | Yes | No | 9 | 8 | 1 | 2 | R:R:F788 | R:R:S805 | 9.25 | 2 | Yes | No | 9 | 8 | 1 | 1 | R:R:F788 | W:W:?1 | 8.28 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:M802 | R:R:Y792 | 3.59 | 2 | No | Yes | 8 | 8 | 2 | 2 | R:R:S805 | W:W:?1 | 4.25 | 2 | No | Yes | 8 | 0 | 1 | 0 | R:R:V806 | W:W:?1 | 4.22 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:S809 | W:W:?1 | 10.21 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:A810 | W:W:?1 | 1.79 | 0 | No | Yes | 7 | 0 | 1 | 0 | W:W:?1 | X:X:?1 | 22.22 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:G745 | R:R:L744 | 1.71 | 0 | No | No | 5 | 8 | 2 | 1 | S:S:L752 | X:X:?1 | 1.57 | 2 | No | Yes | 3 | 0 | 1 | 1 | S:S:L752 | W:W:?1 | 1.57 | 2 | No | Yes | 3 | 0 | 1 | 0 | R:R:L752 | W:W:?1 | 1.57 | 0 | No | Yes | 3 | 0 | 1 | 0 | R:R:I784 | R:R:S805 | 1.55 | 0 | No | No | 8 | 8 | 2 | 1 | R:R:L744 | R:R:V789 | 1.49 | 0 | No | No | 8 | 7 | 1 | 2 | S:S:A813 | X:X:?1 | 0.89 | 0 | No | Yes | 7 | 0 | 2 | 1 | R:R:A813 | W:W:?1 | 0.89 | 0 | No | Yes | 7 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 17.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 6.79 | Average Nodes In Shell | 47.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 62.00 | Average Links Mediated by Hubs In Shell | 56.00 |
| ![](/psngpcr/ligands/YKU/YKU_8T6J_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YKU/YKU_8T6J_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8TAO | C | Aminoacid | Metabotropic glutamate | mGlu5; mGlu5 | Homo sapiens | Quisqualate | CDPPB | - | 2.9 | 2023-10-11 | 10.1101/2023.08.29.555158 |
![](/psngpcr/ligands/YKU/YKU_8TAO_X_X_1.png)
A 2D representation of the interactions of YKU in 8TAO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:I625 | S:S:Y629 | 3.63 | 5 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:I625 | S:S:S658 | 3.1 | 5 | Yes | No | 8 | 6 | 1 | 2 | S:S:I625 | S:S:L814 | 15.7 | 5 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:I625 | X:X:?1 | 2.99 | 5 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:A810 | S:S:Y629 | 6.67 | 0 | No | Yes | 7 | 8 | 1 | 2 | S:S:L814 | S:S:Y629 | 4.69 | 5 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:P655 | S:S:S654 | 3.56 | 0 | No | No | 8 | 7 | 1 | 2 | S:S:P655 | X:X:?1 | 18.36 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:T781 | S:S:Y659 | 6.24 | 5 | No | No | 9 | 7 | 1 | 1 | S:S:Y659 | X:X:?1 | 4.1 | 5 | No | Yes | 7 | 0 | 1 | 0 | S:S:L744 | S:S:W785 | 4.56 | 5 | No | No | 8 | 8 | 1 | 1 | S:S:L744 | X:X:?1 | 6.77 | 5 | No | Yes | 8 | 0 | 1 | 0 | S:S:N747 | X:X:?1 | 2.88 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:I751 | S:S:L752 | 4.28 | 0 | Yes | No | 8 | 3 | 1 | 2 | S:S:I751 | S:S:M778 | 5.83 | 0 | Yes | No | 8 | 9 | 1 | 2 | S:S:I751 | X:X:?1 | 8.97 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:T781 | X:X:?1 | 8.24 | 5 | No | Yes | 9 | 0 | 1 | 0 | S:S:I784 | S:S:S809 | 4.64 | 0 | No | No | 8 | 9 | 2 | 1 | S:S:V789 | S:S:W785 | 11.03 | 0 | No | No | 7 | 8 | 2 | 1 | S:S:W785 | X:X:?1 | 23.87 | 5 | No | Yes | 8 | 0 | 1 | 0 | S:S:F788 | S:S:Y792 | 52.61 | 5 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:F788 | S:S:T801 | 10.38 | 5 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:F788 | S:S:M802 | 6.22 | 5 | Yes | No | 9 | 8 | 1 | 2 | S:S:F788 | S:S:S805 | 9.25 | 5 | Yes | No | 9 | 8 | 1 | 1 | S:S:F788 | X:X:?1 | 4.25 | 5 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:T801 | S:S:Y792 | 14.98 | 5 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:S805 | S:S:Y792 | 6.36 | 5 | No | Yes | 8 | 8 | 1 | 2 | S:S:S805 | X:X:?1 | 6.29 | 5 | No | Yes | 8 | 0 | 1 | 0 | S:S:V806 | X:X:?1 | 6.25 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:S809 | X:X:?1 | 14.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | S:S:A810 | X:X:?1 | 3.3 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:G748 | S:S:I751 | 1.76 | 0 | No | Yes | 5 | 8 | 2 | 1 | S:S:A813 | S:S:I625 | 1.62 | 0 | No | Yes | 7 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.54 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/YKU/YKU_8TAO_X_X_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YKU/YKU_8TAO_X_X_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|