psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C181	R:R:C200	7.28	No	No	0	9	9
2	R:R:S188	R:R:V184	6.46	No	No	0	1	4
3	R:R:G185	R:R:T186	3.64	No	No	0	4	3
4	R:R:A469	R:R:N187	4.69	No	No	0	4	4
5	R:R:I192	R:R:S188	10.84	No	No	0	4	1
6	R:R:D189	R:R:W193	4.47	No	No	0	4	3
7	R:R:Q190	R:R:Y191	6.76	No	No	0	3	3
8	R:R:K203	R:R:W193	9.28	No	No	0	5	3
9	R:R:A287	R:R:V194	5.09	No	No	0	2	5
10	R:R:L198	R:R:R196	7.29	No	Yes	0	3	4
11	R:R:R196	R:R:V201	20.92	Yes	No	0	4	6
12	R:R:E286	R:R:R196	9.3	No	Yes	0	2	4
13	R:R:Q294	R:R:R196	4.67	No	Yes	0	6	4
14	R:R:E295	R:R:R196	3.49	No	Yes	0	7	4
15	R:R:L198	R:R:S197	4.5	No	No	0	3	4
16	R:R:V201	R:R:V291	6.41	No	No	0	6	4
17	R:R:G209	R:R:L202	5.13	No	No	0	6	4
18	R:R:L202	R:R:L210	4.15	No	No	0	4	4
19	R:R:E289	R:R:K203	9.45	No	No	0	3	5
20	R:R:C204	R:R:S281	3.44	No	No	0	8	7
21	R:R:C204	R:R:C282	7.28	No	Yes	0	8	9
22	R:R:R213	R:R:Y206	7.2	No	Yes	0	1	4
23	R:R:D220	R:R:Y206	6.9	No	Yes	1	6	4
24	R:R:R277	R:R:Y206	14.4	Yes	Yes	1	6	4
25	R:R:E278	R:R:Y206	6.73	No	Yes	0	5	4
26	R:R:D207	R:R:R213	15.48	No	No	0	4	1
27	R:R:E372	R:R:G209	4.91	Yes	No	0	6	6
28	R:R:E372	R:R:L210	5.3	Yes	No	0	6	4
29	R:R:E372	R:R:Y211	10.1	Yes	Yes	0	6	7
30	R:R:L373	R:R:Y211	21.1	No	Yes	0	8	7
31	R:R:D471	R:R:Y211	6.9	No	Yes	0	1	7
32	R:R:N473	R:R:Y211	3.49	No	Yes	0	5	7
33	R:R:S212	R:R:S214	4.89	No	No	0	4	3
34	R:R:A215	R:R:S212	3.42	No	No	7	6	4
35	R:R:D471	R:R:S212	8.83	No	No	7	1	4
36	R:R:E217	R:R:R213	9.3	No	No	0	3	1
37	R:R:A215	R:R:D471	6.18	No	No	7	6	1
38	R:R:K216	R:R:R277	13.61	No	Yes	0	6	6
39	R:R:E372	R:R:K216	8.1	Yes	No	0	6	6
40	R:R:F218	R:R:W222	7.02	No	Yes	2	5	8
41	R:R:F218	R:R:M474	4.98	No	No	0	5	4
42	R:R:F218	R:R:M478	4.98	No	No	2	5	6
43	R:R:M223	R:R:T219	4.52	No	No	0	6	5
44	R:R:L373	R:R:T219	8.84	No	No	0	8	5
45	R:R:M478	R:R:T219	7.53	No	No	0	6	5
46	R:R:D220	R:R:R272	5.96	No	Yes	1	6	8
47	R:R:D220	R:R:R277	5.96	No	Yes	1	6	6
48	R:R:W222	R:R:W226	19.68	Yes	Yes	2	8	5
49	R:R:M478	R:R:W222	15.12	No	Yes	2	6	8
50	R:R:I481	R:R:W222	5.87	No	Yes	0	7	8
51	R:R:F482	R:R:W222	5.01	Yes	Yes	2	7	8
52	R:R:M223	R:R:Y269	7.18	No	Yes	0	6	6
53	R:R:M223	R:R:R272	3.72	No	Yes	0	6	8
54	R:R:V225	R:R:W226	12.26	No	Yes	0	4	5
55	R:R:F482	R:R:W226	17.04	Yes	Yes	2	7	5
56	R:R:I489	R:R:W226	4.7	No	Yes	0	8	5
57	R:R:A227	R:R:Y269	4	No	Yes	0	7	6
58	R:R:I489	R:R:L229	4.28	No	No	0	8	5
59	R:R:C230	R:R:S266	5.16	No	No	0	7	8
60	R:R:C230	R:R:L485	4.76	No	No	0	7	8
61	R:R:F231	R:R:N263	10.87	Yes	No	0	4	5
62	R:R:F231	R:R:S266	5.28	Yes	No	0	4	8
63	R:R:F231	R:R:I267	5.02	Yes	No	0	4	4
64	R:R:F231	R:R:I270	3.77	Yes	No	0	4	5
65	R:R:S233	R:R:S491	4.89	No	Yes	0	8	8
66	R:R:N263	R:R:T234	8.77	No	No	0	5	8
67	R:R:S491	R:R:T234	4.8	Yes	No	0	8	8
68	R:R:F236	R:R:T240	5.19	Yes	Yes	3	5	9
69	R:R:F236	R:R:I495	7.54	Yes	Yes	3	5	7
70	R:R:F236	R:R:W504	7.02	Yes	Yes	3	5	9
71	R:R:S259	R:R:T237	7.99	No	No	3	8	8
72	R:R:S491	R:R:T237	6.4	Yes	No	3	8	8
73	R:R:I495	R:R:T237	6.08	Yes	No	3	7	8
74	R:R:M260	R:R:V238	7.61	No	No	0	4	6
75	R:R:L239	R:R:W504	3.42	No	Yes	0	5	9
76	R:R:I495	R:R:T240	4.56	Yes	Yes	3	7	9
77	R:R:T240	R:R:T500	4.71	Yes	No	3	9	8
78	R:R:T240	R:R:W504	9.7	Yes	Yes	3	9	9
79	R:R:F241	R:R:L242	3.65	Yes	No	0	8	5
80	R:R:F241	R:R:S245	5.28	Yes	No	0	8	6
81	R:R:F241	R:R:F248	6.43	Yes	No	8	8	8
82	R:R:F241	R:R:R253	10.69	Yes	No	0	8	9
83	R:R:F241	R:R:I256	13.82	Yes	No	8	8	7
84	R:R:I243	R:R:W504	10.57	No	Yes	0	6	9
85	R:R:F507	R:R:I243	10.05	No	No	0	5	6
86	R:R:D244	R:R:S246	5.89	No	No	0	8	4
87	R:R:D244	R:R:R247	7.15	No	No	0	8	9
88	R:R:K499	R:R:R247	22.28	No	No	0	9	9
89	R:R:E252	R:R:F248	4.66	No	No	0	9	8
90	R:R:F248	R:R:I256	8.79	No	No	8	8	7
91	R:R:P251	R:R:S249	7.13	No	No	9	9	6
92	R:R:E252	R:R:S249	8.62	No	No	0	9	6
93	R:R:H337	R:R:S249	5.58	No	No	9	6	6
94	R:R:R253	R:R:Y250	17.49	No	No	0	9	9
95	R:R:E341	R:R:Y250	22.45	No	No	0	7	9
96	R:R:S344	R:R:Y250	5.09	No	No	0	8	9
97	R:R:H337	R:R:P251	18.3	No	No	9	6	9
98	R:R:I340	R:R:P251	6.77	No	No	0	9	9
99	R:R:E252	R:R:L433	9.28	No	No	0	9	8
100	R:R:L323	R:R:P254	8.21	Yes	No	0	9	8
101	R:R:I255	R:R:L323	7.14	No	Yes	10	8	9
102	R:R:F440	R:R:I255	13.82	No	No	10	9	8
103	R:R:F257	R:R:W319	24.05	No	Yes	6	7	9
104	R:R:F257	R:R:H348	11.31	No	No	6	7	9
105	R:R:L258	R:R:Y262	5.86	No	Yes	0	7	8
106	R:R:S259	R:R:S491	4.89	No	Yes	3	8	8
107	R:R:C261	R:R:F312	4.19	No	No	0	8	8
108	R:R:C261	R:R:S316	3.44	No	No	0	8	8
109	R:R:S316	R:R:Y262	7.63	No	Yes	0	8	8
110	R:R:V487	R:R:Y262	11.36	No	Yes	0	8	8
111	R:R:G488	R:R:Y262	7.24	No	Yes	0	9	8
112	R:R:F312	R:R:I264	17.58	No	No	0	8	5
113	R:R:Y265	R:R:Y269	9.93	Yes	Yes	1	7	6
114	R:R:L309	R:R:Y265	8.21	Yes	Yes	1	6	7
115	R:R:S484	R:R:Y265	3.82	No	Yes	0	6	7
116	R:R:L485	R:R:Y265	3.52	No	Yes	1	8	7
117	R:R:A268	R:R:L308	4.73	No	No	0	6	5
118	R:R:L376	R:R:Y269	5.86	Yes	Yes	1	7	6
119	R:R:I481	R:R:Y269	3.63	No	Yes	0	7	6
120	R:R:L485	R:R:Y269	5.86	No	Yes	1	8	6
121	R:R:L273	R:R:R272	3.64	No	Yes	0	5	8
122	R:R:R272	R:R:R277	13.86	Yes	Yes	1	8	6
123	R:R:L376	R:R:R272	3.64	Yes	Yes	1	7	8
124	R:R:I280	R:R:V275	6.14	No	No	0	6	4
125	R:R:G375	R:R:R277	4.5	No	Yes	0	9	6
126	R:R:C282	R:R:E278	4.56	Yes	No	0	9	5
127	R:R:I280	R:R:I305	5.89	No	Yes	0	6	7
128	R:R:G375	R:R:S281	3.71	No	No	0	9	7
129	R:R:C282	R:R:P290	3.77	Yes	No	0	9	3
130	R:R:D283	R:R:E286	9.09	No	No	0	4	2
131	R:R:F284	R:R:P290	10.11	No	No	0	1	3
132	R:R:L292	R:R:Q382	3.99	No	No	0	5	5
133	R:R:I293	R:R:N299	4.25	No	No	0	6	7
134	R:R:Q294	R:R:Q382	5.12	No	No	0	6	5
135	R:R:E295	R:R:K298	9.45	No	No	0	7	5
136	R:R:L297	R:R:R366	8.5	Yes	No	0	6	6
137	R:R:L297	R:R:V368	5.96	Yes	No	0	6	8
138	R:R:K298	R:R:R366	8.66	No	No	0	5	6
139	R:R:C302	R:R:N299	4.72	No	No	0	9	7
140	R:R:C302	R:R:C377	7.28	No	No	0	9	9
141	R:R:F306	R:R:L307	6.09	Yes	No	0	9	7
142	R:R:F306	R:R:Y310	7.22	Yes	Yes	4	9	9
143	R:R:F306	R:R:I362	7.54	Yes	Yes	4	9	6
144	R:R:F306	R:R:V368	14.42	Yes	No	0	9	8
145	R:R:L309	R:R:L376	5.54	Yes	Yes	1	6	7
146	R:R:L309	R:R:Y378	3.52	Yes	Yes	0	6	6
147	R:R:M314	R:R:Y310	13.17	No	Yes	4	8	9
148	R:R:K358	R:R:Y310	11.94	No	Yes	4	7	9
149	R:R:T359	R:R:Y310	4.99	No	Yes	0	8	9
150	R:R:I362	R:R:Y310	8.46	Yes	Yes	4	6	9
151	R:R:Y310	R:R:Y378	7.94	Yes	Yes	0	9	6
152	R:R:F390	R:R:Y310	5.16	Yes	Yes	4	8	9
153	R:R:F311	R:R:F312	10.72	Yes	No	0	9	8
154	R:R:F311	R:R:W352	4.01	Yes	Yes	0	9	9
155	R:R:F311	R:R:P355	4.33	Yes	No	0	9	9
156	R:R:K358	R:R:M314	8.64	No	No	4	7	8
157	R:R:L395	R:R:M314	5.65	No	No	0	7	8
158	R:R:I318	R:R:I354	5.89	No	No	11	5	4
159	R:R:I318	R:R:P355	3.39	No	No	11	5	9
160	R:R:I318	R:R:Y398	8.46	No	No	0	5	6
161	R:R:I322	R:R:W319	7.05	No	Yes	0	7	9
162	R:R:H348	R:R:W319	9.52	No	Yes	6	9	9
163	R:R:A351	R:R:W319	11.67	No	Yes	0	9	9
164	R:R:W319	R:R:W352	9.37	Yes	Yes	6	9	9
165	R:R:V321	R:R:W320	3.68	No	Yes	0	9	9
166	R:R:T324	R:R:W320	7.28	Yes	Yes	12	8	9
167	R:R:L399	R:R:W320	3.42	No	Yes	0	8	9
168	R:R:G402	R:R:W320	5.63	No	Yes	12	9	9
169	R:R:W320	R:R:Y444	34.73	Yes	No	0	9	8
170	R:R:T445	R:R:W320	3.64	No	Yes	0	7	9
171	R:R:F347	R:R:I322	15.07	No	No	0	8	7
172	R:R:F440	R:R:L323	3.65	No	Yes	10	9	9
173	R:R:L323	R:R:S441	4.5	Yes	No	0	9	8
174	R:R:G402	R:R:T324	5.46	No	Yes	12	9	8
175	R:R:F405	R:R:T324	5.19	No	Yes	0	8	8
176	R:R:I406	R:R:T324	6.08	No	Yes	0	8	8
177	R:R:L325	R:R:L329	6.92	No	No	0	6	8
178	R:R:F347	R:R:L325	3.65	No	No	0	8	6
179	R:R:F405	R:R:L325	10.96	No	No	0	8	6
180	R:R:F347	R:R:T326	3.89	No	No	0	8	8
181	R:R:A331	R:R:W327	7.78	No	Yes	0	8	9
182	R:R:G409	R:R:W327	4.22	No	Yes	0	9	9
183	R:R:M434	R:R:W327	6.98	Yes	Yes	0	8	9
184	R:R:I437	R:R:W327	4.7	No	Yes	0	8	9
185	R:R:G438	R:R:W327	5.63	No	Yes	0	8	9
186	R:R:F328	R:R:L329	3.65	No	No	0	7	8
187	R:R:F328	R:R:L333	8.53	No	No	0	7	6
188	R:R:A408	R:R:F328	5.55	No	No	0	5	7
189	R:R:L329	R:R:W335	19.36	No	Yes	0	8	8
190	R:R:L333	R:R:W335	3.42	No	Yes	0	6	8
191	R:R:A339	R:R:W335	5.19	No	Yes	0	8	8
192	R:R:I340	R:R:W335	3.52	No	Yes	0	9	8
193	R:R:H343	R:R:W335	7.41	No	Yes	0	6	8
194	R:R:E431	R:R:H337	7.39	No	No	0	8	6
195	R:R:H348	R:R:W352	8.46	No	Yes	6	9	9
196	R:R:I354	R:R:P355	3.39	No	No	11	4	9
197	R:R:K358	R:R:Y398	7.17	No	No	0	7	6
198	R:R:F390	R:R:V361	3.93	Yes	No	0	8	4
199	R:R:I362	R:R:V379	7.68	Yes	No	0	6	8
200	R:R:F390	R:R:I362	12.56	Yes	Yes	4	8	6
201	R:R:L367	R:R:M365	4.24	No	No	0	6	5
202	R:R:A386	R:R:L367	6.3	No	No	0	5	6
203	R:R:F390	R:R:L367	3.65	Yes	No	0	8	6
204	R:R:D369	R:R:N381	9.42	No	No	0	8	7
205	R:R:D369	R:R:Q382	13.05	No	No	0	8	5
206	R:R:D371	R:R:T374	7.23	No	No	0	9	8
207	R:R:D371	R:R:N381	10.77	No	No	0	9	7
208	R:R:L376	R:R:T374	8.84	Yes	No	0	7	8
209	R:R:V379	R:R:Y378	5.05	No	Yes	0	8	6
210	R:R:N381	R:R:Y378	3.49	No	Yes	0	7	6
211	R:R:V391	R:R:Y378	8.83	No	Yes	0	7	6
212	R:R:G380	R:R:L387	3.42	No	Yes	0	9	8
213	R:R:D385	R:R:N383	4.04	No	No	0	2	6
214	R:R:A386	R:R:N383	6.25	No	No	0	5	6
215	R:R:I459	R:R:L384	4.28	No	No	0	6	2
216	R:R:L384	R:R:W462	19.36	No	Yes	0	2	7
217	R:R:L387	R:R:V391	4.47	Yes	No	5	8	7
218	R:R:L387	R:R:Y455	4.69	Yes	Yes	5	8	4
219	R:R:E458	R:R:L387	3.98	Yes	Yes	5	9	8
220	R:R:L387	R:R:W462	3.42	Yes	Yes	5	8	7
221	R:R:I459	R:R:T388	6.08	No	No	0	6	6
222	R:R:V391	R:R:Y455	5.05	No	Yes	5	7	4
223	R:R:V392	R:R:Y455	3.79	No	Yes	0	6	4
224	R:R:I459	R:R:V392	4.61	No	No	0	6	6
225	R:R:P394	R:R:Y398	4.17	No	No	0	9	6
226	R:R:F396	R:R:V400	6.55	No	No	0	2	3
227	R:R:F405	R:R:I401	3.77	No	No	0	8	4
228	R:R:F414	R:R:R417	5.34	No	No	0	5	8
229	R:R:L430	R:R:V435	4.47	Yes	No	0	8	6
230	R:R:E431	R:R:L433	9.28	No	No	0	8	8
231	R:R:E431	R:R:M434	4.06	No	Yes	0	8	8
232	R:R:R432	R:R:V435	6.54	No	No	0	7	6
233	R:R:I437	R:R:L433	7.14	No	No	0	8	8
234	R:R:K436	R:R:W494	4.64	No	No	0	9	9
235	R:R:L443	R:R:V439	4.47	No	No	0	8	5
236	R:R:V439	R:R:W494	3.68	No	No	0	5	9
237	R:R:F440	R:R:W494	18.04	No	No	0	9	9
238	R:R:V487	R:R:Y444	6.31	No	No	0	8	8
239	R:R:P447	R:R:V446	3.53	No	No	0	8	6
240	R:R:I450	R:R:L479	4.28	No	No	2	4	6
241	R:R:I450	R:R:M483	11.66	No	Yes	2	4	9
242	R:R:C454	R:R:V476	3.42	No	No	0	6	6
243	R:R:C454	R:R:K480	6.47	No	Yes	0	6	8
244	R:R:K480	R:R:Y455	19.11	Yes	Yes	0	8	4
245	R:R:F456	R:R:S460	7.93	No	No	0	4	3
246	R:R:N461	R:R:Y457	8.14	No	No	0	5	8
247	R:R:F465	R:R:Y457	4.13	Yes	No	0	8	8
248	R:R:E458	R:R:W462	5.45	Yes	Yes	5	9	7
249	R:R:E458	R:R:F465	19.82	Yes	Yes	0	9	8
250	R:R:E458	R:R:K480	6.75	Yes	Yes	0	9	8
251	R:R:L464	R:R:N461	4.12	No	No	0	1	5
252	R:R:R466	R:R:W462	11	No	Yes	0	4	7
253	R:R:L464	R:R:S468	4.5	No	No	0	1	4
254	R:R:L464	R:R:N473	4.12	No	No	0	1	5
255	R:R:F465	R:R:N473	26.58	Yes	No	0	8	5
256	R:R:E477	R:R:F465	3.5	No	Yes	0	6	8
257	R:R:R466	R:R:Y467	20.58	No	No	0	4	1
258	R:R:D470	R:R:S468	4.42	No	No	0	2	4
259	R:R:D470	R:R:S472	10.31	No	No	0	2	8
260	R:R:E477	R:R:K480	8.1	No	Yes	0	6	8
261	R:R:L479	R:R:M483	4.24	No	Yes	2	6	9
262	R:R:F482	R:R:M483	4.98	Yes	Yes	2	7	9
263	R:R:F482	R:R:L486	4.87	Yes	No	0	7	5
264	R:R:G492	R:R:S491	3.71	No	Yes	0	7	8
265	R:R:I495	R:R:T500	4.56	Yes	No	3	7	8
266	R:R:L501	R:R:Q505	10.65	No	No	0	3	5
267	R:R:N509	R:R:R510	3.62	No	No	0	3	7
268	R:R:N513	R:R:R510	4.82	No	No	0	3	7
269	R:R:N513	R:R:V512	4.43	No	No	0	3	2
270	R:R:M483	R:R:P447	3.35	Yes	No	0	9	8
271	R:R:C200	R:R:K195	3.23	No	No	0	9	5
272	R:R:S484	R:R:V451	3.23	No	No	0	6	7
273	R:R:A330	R:R:M434	3.22	No	Yes	0	8	8
274	R:R:V194	R:R:V291	3.21	No	No	0	5	4
275	R:R:S441	R:R:T324	3.2	No	Yes	0	8	8
276	R:R:A469	R:R:L210	3.15	No	No	0	4	4
277	R:R:A268	R:R:L309	3.15	No	Yes	0	6	6
278	R:R:E289	R:R:P290	3.14	No	No	0	3	3
279	R:R:C181	R:R:D189	3.11	No	No	0	9	4
280	R:R:I305	R:R:V271	3.07	Yes	No	0	7	4
281	R:R:I406	R:R:V442	3.07	No	No	0	8	5
282	R:R:I243	R:R:T503	3.04	No	No	0	6	7
283	R:R:I401	R:R:T397	3.04	No	No	0	4	4
284	R:R:F236	R:R:W496	3.01	Yes	No	0	5	6
285	R:R:M493	R:R:T490	3.01	No	No	0	6	7
286	R:R:L395	R:R:S317	3	No	No	0	7	6
287	R:R:L242	R:R:V238	2.98	No	No	0	5	6
288	R:R:L404	R:R:V400	2.98	No	No	0	4	3
289	R:R:N461	R:R:S460	2.98	No	No	0	5	3
290	R:R:C181	R:R:H182	2.95	No	No	0	9	4
291	R:R:L399	R:R:T403	2.95	No	No	0	8	5
292	R:R:L486	R:R:T490	2.95	No	No	0	5	7
293	R:R:A498	R:R:H502	2.93	No	No	0	4	4
294	R:R:G313	R:R:Y265	2.9	No	Yes	0	5	7
295	R:R:I192	R:R:L202	2.85	No	No	0	4	4
296	R:R:I304	R:R:L308	2.85	No	No	0	5	5
297	R:R:I305	R:R:L309	2.85	Yes	Yes	1	7	6
298	R:R:I305	R:R:L376	2.85	Yes	Yes	1	7	7
299	R:R:I452	R:R:L399	2.85	No	No	0	6	8
300	R:R:L430	R:R:M434	2.83	Yes	Yes	0	8	8
301	R:R:D283	R:R:I293	2.8	No	No	0	4	6
302	R:R:H182	R:R:S183	2.79	No	No	0	4	2
303	R:R:L297	R:R:L363	2.77	Yes	No	0	6	8
304	R:R:L307	R:R:L363	2.77	No	No	0	7	8
305	R:R:L413	R:R:L430	2.77	No	Yes	14	8	8
306	R:R:A208	R:R:Y191	2.67	No	No	0	4	3
307	R:R:A448	R:R:Y444	2.67	No	No	0	8	8
308	R:R:H343	R:R:M342	2.63	No	No	0	6	5
309	R:R:R279	R:R:V275	2.62	No	No	0	3	4
310	R:R:R247	R:R:T503	2.59	No	No	0	9	7
311	R:R:A315	R:R:W352	2.59	No	Yes	0	9	9
312	R:R:F396	R:R:I452	2.51	No	No	0	2	6
313	R:R:N187	R:R:Y191	2.33	No	No	0	4	3
314	R:R:L410	R:R:W327	2.28	No	Yes	0	7	9
315	R:R:G332	R:R:G409	2.11	No	No	13	7	9
316	R:R:C282	R:R:G205	1.96	Yes	No	0	9	3
317	R:R:C302	R:R:G296	1.96	No	No	0	9	6
318	R:R:A412	R:R:G332	1.95	No	No	13	7	7
319	R:R:A412	R:R:G409	1.95	No	No	13	7	9
320	R:R:A393	R:R:P394	1.87	No	No	0	4	9
321	R:R:G185	R:R:V184	1.84	No	No	0	4	4
322	R:R:G276	R:R:V275	1.84	No	No	0	6	4
323	R:R:G301	R:R:T300	1.82	No	No	0	4	5
324	R:R:G389	R:R:T388	1.82	No	No	0	1	6
325	R:R:A370	R:R:C377	1.81	No	No	0	8	9
326	R:R:G301	R:R:I280	1.76	No	No	0	4	6
327	R:R:E338	R:R:G336	1.64	No	No	0	9	7
328	R:R:A350	R:R:I354	1.62	No	No	0	5	4
329	R:R:S497	R:R:T500	1.6	No	No	0	9	8
330	R:R:A224	R:R:L273	1.58	No	No	0	4	5
331	R:R:A303	R:R:L297	1.58	No	Yes	0	8	6
332	R:R:A235	R:R:N263	1.56	No	No	0	5	5
333	R:R:I221	R:R:V225	1.54	No	No	0	1	4
334	R:R:I270	R:R:T274	1.52	No	No	0	5	3
335	R:R:I450	R:R:T449	1.52	No	No	0	4	5
336	R:R:I360	R:R:I364	1.47	No	No	0	7	7
337	R:R:I416	R:R:K334	1.45	No	No	0	8	8
338	R:R:K334	R:R:L413	1.41	No	No	14	8	8
339	R:R:K334	R:R:L430	1.41	No	Yes	14	8	8
340	R:R:K195	R:R:N199	1.4	No	No	0	5	5
341	R:R:A356	R:R:F311	1.39	No	Yes	0	8	9
342	R:R:H502	R:R:K506	1.31	No	No	0	4	3
343	R:R:D283	R:R:E285	1.3	No	No	0	4	4
344	R:R:H502	R:R:Q505	1.24	No	No	0	4	5
345	R:R:F414	R:R:L410	1.22	No	No	0	5	7
346	R:R:F507	R:R:L511	1.22	No	No	0	5	3
347	R:R:N509	R:R:Y508	1.16	No	No	0	3	3
348	R:R:H343	R:R:Y346	1.09	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R196	9.134	5	0	4
2	R:R:Y206	8.8075	4	1	4
3	R:R:Y211	10.3975	4	0	7
4	R:R:W222	10.54	5	2	8
5	R:R:W226	13.42	4	2	5
6	R:R:F231	6.235	4	0	4
7	R:R:F236	5.69	4	3	5
8	R:R:T240	6.04	4	3	9
9	R:R:F241	7.974	5	8	8
10	R:R:Y262	8.0225	4	0	8
11	R:R:Y265	5.676	5	1	7
12	R:R:Y269	6.07667	6	1	6
13	R:R:R272	6.164	5	1	8
14	R:R:R277	10.466	5	1	6
15	R:R:C282	4.3925	4	0	9
16	R:R:L297	4.7025	4	0	6
17	R:R:I305	3.665	4	1	7
18	R:R:F306	8.8175	4	4	9
19	R:R:L309	4.654	5	1	6
20	R:R:Y310	8.41143	7	4	9
21	R:R:F311	5.1125	4	0	9
22	R:R:W319	12.332	5	6	9
23	R:R:W320	9.73	6	12	9
24	R:R:L323	5.875	4	10	9
25	R:R:T324	5.442	5	12	8
26	R:R:W327	5.265	6	0	9
27	R:R:W335	7.78	5	0	8
28	R:R:W352	6.1075	4	6	9
29	R:R:I362	9.06	4	4	6
30	R:R:E372	7.1025	4	0	6
31	R:R:L376	5.346	5	1	7
32	R:R:Y378	5.766	5	0	6
33	R:R:L387	3.996	5	5	8
34	R:R:F390	6.325	4	4	8
35	R:R:L430	2.87	4	14	8
36	R:R:M434	4.2725	4	0	8
37	R:R:Y455	8.16	4	5	4
38	R:R:E458	9	4	5	9
39	R:R:W462	9.8075	4	5	7
40	R:R:F465	13.5075	4	0	8
41	R:R:K480	10.1075	4	0	8
42	R:R:F482	7.975	4	2	7
43	R:R:M483	6.0575	4	2	9
44	R:R:S491	4.938	5	3	8
45	R:R:I495	5.685	4	3	7
46	R:R:W504	7.6775	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C181	R:R:D189	15.7529	3.11	No	No	0	9	4
2	R:R:D189	R:R:W193	18.3556	4.47	No	No	0	4	3
3	R:R:K203	R:R:W193	20.9516	9.28	No	No	0	5	3
4	R:R:E289	R:R:K203	23.541	9.45	No	No	0	3	5
5	R:R:E289	R:R:P290	26.1237	3.14	No	No	0	3	3
6	R:R:C282	R:R:P290	31.269	3.77	Yes	No	0	9	3
7	R:R:C282	R:R:E278	36.2708	4.56	Yes	No	0	9	5
8	R:R:E278	R:R:Y206	38.8068	6.73	No	Yes	0	5	4
9	R:R:R277	R:R:Y206	26.0202	14.4	Yes	Yes	1	6	4
10	R:R:K216	R:R:R277	24.839	13.61	No	Yes	0	6	6
11	R:R:E372	R:R:K216	23.8647	8.1	Yes	No	0	6	6
12	R:R:I192	R:R:L202	14.4116	2.85	No	No	0	4	4
13	R:R:I192	R:R:S188	11.5419	10.84	No	No	0	4	1
14	R:R:E372	R:R:L210	16.9508	5.3	Yes	No	0	6	4
15	R:R:Q294	R:R:R196	24.3952	4.67	No	Yes	0	6	4
16	R:R:Q294	R:R:Q382	25.7866	5.12	No	No	0	6	5
17	R:R:D369	R:R:Q382	28.4961	13.05	No	No	0	8	5
18	R:R:D369	R:R:N381	29.8942	9.42	No	No	0	8	7
19	R:R:L376	R:R:R272	61.637	3.64	Yes	Yes	1	7	8
20	R:R:D220	R:R:R272	23.9414	5.96	No	Yes	1	6	8
21	R:R:D220	R:R:Y206	22.8036	6.9	No	Yes	1	6	4
22	R:R:N381	R:R:Y378	25.0392	3.49	No	Yes	0	7	6
23	R:R:L309	R:R:Y378	100	3.52	Yes	Yes	0	6	6
24	R:R:L309	R:R:L376	55.7843	5.54	Yes	Yes	1	6	7
25	R:R:R272	R:R:R277	48.5168	13.86	Yes	Yes	1	8	6
26	R:R:E286	R:R:R196	13.6908	9.3	No	Yes	0	2	4
27	R:R:E372	R:R:Y211	10.2439	10.1	Yes	Yes	0	6	7
28	R:R:M223	R:R:R272	19.8071	3.72	No	Yes	0	6	8
29	R:R:M223	R:R:T219	15.9765	4.52	No	No	0	6	5
30	R:R:L373	R:R:T219	12.3528	8.84	No	No	0	8	5
31	R:R:L373	R:R:Y211	10.4708	21.1	No	Yes	0	8	7
32	R:R:N473	R:R:Y211	11.3417	3.49	No	Yes	0	5	7
33	R:R:M223	R:R:Y269	24.5387	7.18	No	Yes	0	6	6
34	R:R:I481	R:R:Y269	33.5146	3.63	No	Yes	0	7	6
35	R:R:I481	R:R:W222	31.7128	5.87	No	Yes	0	7	8
36	R:R:L376	R:R:Y269	32.5136	5.86	Yes	Yes	1	7	6
37	R:R:W222	R:R:W226	10.3073	19.68	Yes	Yes	2	8	5
38	R:R:F482	R:R:W222	20.618	5.01	Yes	Yes	2	7	8
39	R:R:L485	R:R:Y269	27.8588	5.86	No	Yes	1	8	6
40	R:R:C230	R:R:L485	51.8903	4.76	No	No	0	7	8
41	R:R:C230	R:R:S266	50.7091	5.16	No	No	0	7	8
42	R:R:F231	R:R:S266	49.5212	5.28	Yes	No	0	4	8
43	R:R:F231	R:R:N263	44.7029	10.87	Yes	No	0	4	5
44	R:R:N263	R:R:T234	42.2537	8.77	No	No	0	5	8
45	R:R:S491	R:R:T234	41.0191	4.8	Yes	No	0	8	8
46	R:R:S491	R:R:T237	35.9238	6.4	Yes	No	3	8	8
47	R:R:I495	R:R:T237	34.7292	6.08	Yes	No	3	7	8
48	R:R:F236	R:R:I495	16.1267	7.54	Yes	Yes	3	5	7
49	R:R:I495	R:R:T240	14.7552	4.56	Yes	Yes	3	7	9
50	R:R:F236	R:R:W504	13.4472	7.02	Yes	Yes	3	5	9
51	R:R:T240	R:R:W504	13.5674	9.7	Yes	Yes	3	9	9
52	R:R:Y310	R:R:Y378	99.6096	7.94	Yes	Yes	0	9	6
53	R:R:K358	R:R:Y310	90.4168	11.94	No	Yes	4	7	9
54	R:R:K358	R:R:Y398	90.9406	7.17	No	No	0	7	6
55	R:R:I318	R:R:Y398	89.369	8.46	No	No	0	5	6
56	R:R:I318	R:R:P355	87.0333	3.39	No	No	11	5	9
57	R:R:F311	R:R:P355	87.1133	4.33	Yes	No	0	9	9
58	R:R:F311	R:R:W352	68.5608	4.01	Yes	Yes	0	9	9
59	R:R:W319	R:R:W352	65.3375	9.37	Yes	Yes	6	9	9
60	R:R:I322	R:R:W319	63.569	7.05	No	Yes	0	7	9
61	R:R:F347	R:R:I322	62.8816	15.07	No	No	0	8	7
62	R:R:F347	R:R:L325	61.5202	3.65	No	No	0	8	6
63	R:R:L325	R:R:L329	50.4955	6.92	No	No	0	6	8
64	R:R:L329	R:R:W335	46.6983	19.36	No	Yes	0	8	8
65	R:R:I340	R:R:W335	41.3194	3.52	No	Yes	0	9	8
66	R:R:I340	R:R:P251	40.3484	6.77	No	No	0	9	9
67	R:R:P251	R:R:S249	16.4603	7.13	No	No	9	9	6
68	R:R:E252	R:R:S249	15.476	8.62	No	No	0	9	6
69	R:R:E252	R:R:F248	12.93	4.66	No	No	0	9	8
70	R:R:F241	R:R:F248	10.6243	6.43	Yes	No	8	8	8
71	R:R:I243	R:R:W504	21.6857	10.57	No	Yes	0	6	9
72	R:R:I243	R:R:T503	13.5907	3.04	No	No	0	6	7
73	R:R:R247	R:R:T503	10.8512	2.59	No	No	0	9	7
74	R:R:H337	R:R:P251	22.907	18.3	No	No	9	6	9
75	R:R:E431	R:R:H337	21.9227	7.39	No	No	0	8	6
76	R:R:F405	R:R:L325	20.5546	10.96	No	No	0	8	6
77	R:R:F405	R:R:T324	17.5314	5.19	No	Yes	0	8	8
78	R:R:S441	R:R:T324	10.6443	3.2	No	Yes	0	8	8
79	R:R:F311	R:R:F312	18.9162	10.72	Yes	No	0	9	8
80	R:R:C261	R:R:F312	16.8875	4.19	No	No	0	8	8
81	R:R:C261	R:R:S316	15.8831	3.44	No	No	0	8	8
82	R:R:S316	R:R:Y262	15.199	7.63	No	Yes	0	8	8
83	R:R:V487	R:R:Y262	13.1469	11.36	No	Yes	0	8	8
84	R:R:Y265	R:R:Y269	17.2311	9.93	Yes	Yes	1	7	6
85	R:R:L309	R:R:Y265	42.6908	8.21	Yes	Yes	1	6	7
86	R:R:D283	R:R:E286	12.1959	9.09	No	No	0	4	2
87	R:R:V487	R:R:Y444	12.4562	6.31	No	No	0	8	8
88	R:R:W320	R:R:Y444	11.1081	34.73	Yes	No	0	9	8
89	R:R:M434	R:R:W327	10.2005	6.98	Yes	Yes	0	8	9
90	R:R:E431	R:R:M434	19.043	4.06	No	Yes	0	8	8
91	R:R:V391	R:R:Y378	25.0192	8.83	No	Yes	0	7	6
92	R:R:L387	R:R:V391	15.2758	4.47	Yes	No	5	8	7
93	R:R:F465	R:R:N473	10.5476	26.58	Yes	No	0	8	5
94	R:R:E458	R:R:F465	11.8789	19.82	Yes	Yes	0	9	8
95	R:R:F482	R:R:M483	12.5496	4.98	Yes	Yes	2	7	9
96	R:R:L485	R:R:Y265	25.2027	3.52	No	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6BD4

PDB Summary
PDB	6BD4
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD4
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.4
Date	2018-08-22
D.O.I.	10.1038/s41586-018-0447-x

Net Summary
I_min	3.39
Number of Linked Nodes	308
Number of Links	348
Number of Hubs	46
Number of Links mediated by Hubs	169
Number of Communities	14
Number of Nodes involved in Communities	65
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	68721
Length Of Smallest Path	3
Average Path Length	17.0093
Length of Longest Path	41
Minimum Path Strength	1.275
Average Path Strength	7.14414
Maximum Path Strength	23.2
Minimum Path Correlation	0.7
Average Path Correlation	0.936172
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	48.1057
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3512
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9ULV1
Sequence	>6BD4_Chain_R C H S V G T N S D Q Y I W V K R S L N C V L K C G Y D A G L Y S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D S S R F S Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G R E R I S C D F E E A A E P V L I Q E G L K N T G C A I I F L L L Y F F G M A S S I W W V I L T L T W F L A A G L K W G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R L V D A D E L T G L C Y V G N Q N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N D K L E R L M V K I G V F S V L Y T V P A T I V I A C Y F Y E I S N W A L F R Y S A D D S N M A V E M L K I F M S L L V G I T S G M W I W S A K T L H T W Q K F Y N R L V N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI

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