psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C181	R:R:C200	7.28	No	No	0	9	9
2	R:R:S188	R:R:V184	6.46	No	No	0	1	4
3	R:R:G185	R:R:T186	3.64	No	No	0	4	3
4	R:R:A469	R:R:N187	4.69	No	No	0	4	4
5	R:R:I192	R:R:S188	10.84	No	No	0	4	1
6	R:R:Q190	R:R:Y191	6.76	No	No	0	3	3
7	R:R:K203	R:R:W193	10.44	No	No	0	5	3
8	R:R:A287	R:R:V194	5.09	No	No	0	2	5
9	R:R:L198	R:R:R196	10.93	No	Yes	0	3	4
10	R:R:R196	R:R:V201	10.46	Yes	No	0	4	6
11	R:R:E286	R:R:R196	24.42	No	Yes	0	2	4
12	R:R:E295	R:R:R196	10.47	No	Yes	0	7	4
13	R:R:L198	R:R:S197	4.5	No	No	0	3	4
14	R:R:V201	R:R:V291	6.41	No	No	0	6	4
15	R:R:G209	R:R:L202	5.13	No	No	0	6	4
16	R:R:L202	R:R:L210	4.15	No	No	0	4	4
17	R:R:E289	R:R:K203	9.45	No	No	0	3	5
18	R:R:C204	R:R:S281	3.44	No	No	0	8	7
19	R:R:C204	R:R:C282	7.28	No	Yes	0	8	9
20	R:R:R213	R:R:Y206	7.2	No	Yes	0	1	4
21	R:R:D220	R:R:Y206	6.9	No	Yes	1	6	4
22	R:R:R277	R:R:Y206	14.4	Yes	Yes	1	6	4
23	R:R:E278	R:R:Y206	6.73	No	Yes	0	5	4
24	R:R:D207	R:R:R213	15.48	No	No	0	4	1
25	R:R:E372	R:R:G209	4.91	Yes	No	0	6	6
26	R:R:E372	R:R:L210	5.3	Yes	No	0	6	4
27	R:R:E372	R:R:Y211	10.1	Yes	Yes	0	6	7
28	R:R:L373	R:R:Y211	21.1	No	Yes	0	8	7
29	R:R:D471	R:R:Y211	6.9	No	Yes	0	1	7
30	R:R:N473	R:R:Y211	3.49	No	Yes	0	5	7
31	R:R:S212	R:R:S214	4.89	No	No	0	4	3
32	R:R:A215	R:R:S212	3.42	No	No	7	6	4
33	R:R:D471	R:R:S212	8.83	No	No	7	1	4
34	R:R:E217	R:R:R213	9.3	No	No	0	3	1
35	R:R:A215	R:R:D471	6.18	No	No	7	6	1
36	R:R:K216	R:R:R277	13.61	No	Yes	0	6	6
37	R:R:E372	R:R:K216	8.1	Yes	No	0	6	6
38	R:R:F218	R:R:W222	7.02	No	Yes	2	5	8
39	R:R:F218	R:R:M474	4.98	No	No	0	5	4
40	R:R:F218	R:R:M478	4.98	No	No	2	5	6
41	R:R:M223	R:R:T219	4.52	No	No	0	6	5
42	R:R:L373	R:R:T219	8.84	No	No	0	8	5
43	R:R:M478	R:R:T219	7.53	No	No	0	6	5
44	R:R:D220	R:R:R272	5.96	No	Yes	1	6	8
45	R:R:D220	R:R:R277	5.96	No	Yes	1	6	6
46	R:R:W222	R:R:W226	19.68	Yes	Yes	2	8	5
47	R:R:M478	R:R:W222	15.12	No	Yes	2	6	8
48	R:R:I481	R:R:W222	5.87	No	Yes	0	7	8
49	R:R:F482	R:R:W222	5.01	Yes	Yes	2	7	8
50	R:R:M223	R:R:Y269	7.18	No	Yes	0	6	6
51	R:R:M223	R:R:R272	3.72	No	Yes	0	6	8
52	R:R:V225	R:R:W226	12.26	No	Yes	0	4	5
53	R:R:F482	R:R:W226	17.04	Yes	Yes	2	7	5
54	R:R:I489	R:R:W226	4.7	No	Yes	0	8	5
55	R:R:A227	R:R:Y269	4	No	Yes	0	7	6
56	R:R:I489	R:R:L229	4.28	No	No	0	8	5
57	R:R:C230	R:R:S266	5.16	No	No	0	7	8
58	R:R:C230	R:R:L485	4.76	No	No	0	7	8
59	R:R:F231	R:R:N263	10.87	Yes	No	0	4	5
60	R:R:F231	R:R:S266	5.28	Yes	No	0	4	8
61	R:R:F231	R:R:I267	5.02	Yes	No	0	4	4
62	R:R:F231	R:R:I270	3.77	Yes	No	0	4	5
63	R:R:S233	R:R:S491	4.89	No	Yes	0	8	8
64	R:R:N263	R:R:T234	8.77	No	No	0	5	8
65	R:R:S491	R:R:T234	4.8	Yes	No	0	8	8
66	R:R:F236	R:R:T240	5.19	Yes	Yes	3	5	9
67	R:R:F236	R:R:I495	7.54	Yes	Yes	3	5	7
68	R:R:F236	R:R:W504	7.02	Yes	Yes	3	5	9
69	R:R:S259	R:R:T237	7.99	No	No	3	8	8
70	R:R:S491	R:R:T237	6.4	Yes	No	3	8	8
71	R:R:I495	R:R:T237	6.08	Yes	No	3	7	8
72	R:R:M260	R:R:V238	7.61	No	No	0	4	6
73	R:R:L239	R:R:W504	3.42	No	Yes	0	5	9
74	R:R:I495	R:R:T240	4.56	Yes	Yes	3	7	9
75	R:R:T240	R:R:T500	4.71	Yes	No	3	9	8
76	R:R:T240	R:R:W504	9.7	Yes	Yes	3	9	9
77	R:R:F241	R:R:L242	3.65	Yes	No	0	8	5
78	R:R:F241	R:R:S245	5.28	Yes	No	0	8	6
79	R:R:F241	R:R:F248	6.43	Yes	No	8	8	8
80	R:R:F241	R:R:R253	10.69	Yes	No	0	8	9
81	R:R:F241	R:R:I256	13.82	Yes	No	8	8	7
82	R:R:I243	R:R:W504	10.57	No	Yes	0	6	9
83	R:R:F507	R:R:I243	10.05	No	No	0	5	6
84	R:R:D244	R:R:S246	5.89	No	No	0	8	4
85	R:R:D244	R:R:R247	7.15	No	No	0	8	9
86	R:R:K499	R:R:R247	22.28	No	No	0	9	9
87	R:R:E252	R:R:F248	4.66	No	No	0	9	8
88	R:R:F248	R:R:I256	8.79	No	No	8	8	7
89	R:R:P251	R:R:S249	7.13	No	No	9	9	6
90	R:R:E252	R:R:S249	8.62	No	No	0	9	6
91	R:R:H337	R:R:S249	5.58	No	No	9	6	6
92	R:R:R253	R:R:Y250	17.49	No	No	0	9	9
93	R:R:E341	R:R:Y250	22.45	No	No	0	7	9
94	R:R:S344	R:R:Y250	5.09	No	No	0	8	9
95	R:R:H337	R:R:P251	18.3	No	No	9	6	9
96	R:R:I340	R:R:P251	6.77	No	No	0	9	9
97	R:R:E252	R:R:L433	9.28	No	No	0	9	8
98	R:R:L323	R:R:P254	8.21	Yes	No	0	9	8
99	R:R:I255	R:R:L323	7.14	No	Yes	10	8	9
100	R:R:F440	R:R:I255	13.82	No	No	10	9	8
101	R:R:F257	R:R:W319	24.05	No	Yes	6	7	9
102	R:R:F257	R:R:H348	11.31	No	No	6	7	9
103	R:R:L258	R:R:Y262	5.86	No	Yes	0	7	8
104	R:R:S259	R:R:S491	4.89	No	Yes	3	8	8
105	R:R:C261	R:R:F312	4.19	No	No	0	8	8
106	R:R:C261	R:R:S316	3.44	No	No	0	8	8
107	R:R:S316	R:R:Y262	7.63	No	Yes	0	8	8
108	R:R:V487	R:R:Y262	11.36	No	Yes	0	8	8
109	R:R:G488	R:R:Y262	7.24	No	Yes	0	9	8
110	R:R:F312	R:R:I264	17.58	No	No	0	8	5
111	R:R:Y265	R:R:Y269	9.93	Yes	Yes	1	7	6
112	R:R:L309	R:R:Y265	8.21	Yes	Yes	1	6	7
113	R:R:S484	R:R:Y265	3.82	No	Yes	0	6	7
114	R:R:L485	R:R:Y265	3.52	No	Yes	1	8	7
115	R:R:A268	R:R:L308	4.73	No	No	0	6	5
116	R:R:L376	R:R:Y269	5.86	Yes	Yes	1	7	6
117	R:R:I481	R:R:Y269	3.63	No	Yes	0	7	6
118	R:R:L485	R:R:Y269	5.86	No	Yes	1	8	6
119	R:R:L273	R:R:R272	3.64	No	Yes	0	5	8
120	R:R:R272	R:R:R277	13.86	Yes	Yes	1	8	6
121	R:R:L376	R:R:R272	3.64	Yes	Yes	1	7	8
122	R:R:I280	R:R:V275	6.14	No	No	0	6	4
123	R:R:G375	R:R:R277	4.5	No	Yes	0	9	6
124	R:R:C282	R:R:E278	4.56	Yes	No	0	9	5
125	R:R:I280	R:R:I305	5.89	No	Yes	0	6	7
126	R:R:G375	R:R:S281	3.71	No	No	0	9	7
127	R:R:C282	R:R:P290	3.77	Yes	No	0	9	3
128	R:R:D283	R:R:E286	9.09	No	No	0	4	2
129	R:R:F284	R:R:P290	10.11	No	No	0	1	3
130	R:R:L292	R:R:Q382	3.99	No	No	0	5	5
131	R:R:I293	R:R:N299	4.25	No	No	0	6	7
132	R:R:Q294	R:R:Q382	5.12	No	No	0	6	5
133	R:R:E295	R:R:K298	9.45	No	No	0	7	5
134	R:R:L297	R:R:R366	8.5	Yes	No	0	6	6
135	R:R:L297	R:R:V368	5.96	Yes	No	0	6	8
136	R:R:K298	R:R:R366	8.66	No	No	0	5	6
137	R:R:C302	R:R:N299	4.72	No	No	0	9	7
138	R:R:C302	R:R:C377	7.28	No	No	0	9	9
139	R:R:F306	R:R:L307	6.09	Yes	No	0	9	7
140	R:R:F306	R:R:Y310	7.22	Yes	Yes	4	9	9
141	R:R:F306	R:R:I362	7.54	Yes	Yes	4	9	6
142	R:R:F306	R:R:V368	14.42	Yes	No	0	9	8
143	R:R:L309	R:R:L376	5.54	Yes	Yes	1	6	7
144	R:R:L309	R:R:Y378	3.52	Yes	Yes	0	6	6
145	R:R:M314	R:R:Y310	13.17	No	Yes	4	8	9
146	R:R:K358	R:R:Y310	11.94	No	Yes	4	7	9
147	R:R:T359	R:R:Y310	4.99	No	Yes	0	8	9
148	R:R:I362	R:R:Y310	8.46	Yes	Yes	4	6	9
149	R:R:Y310	R:R:Y378	7.94	Yes	Yes	0	9	6
150	R:R:F390	R:R:Y310	5.16	Yes	Yes	4	8	9
151	R:R:F311	R:R:F312	10.72	Yes	No	0	9	8
152	R:R:F311	R:R:W352	4.01	Yes	Yes	0	9	9
153	R:R:F311	R:R:P355	4.33	Yes	No	0	9	9
154	R:R:K358	R:R:M314	8.64	No	No	4	7	8
155	R:R:L395	R:R:M314	5.65	No	No	0	7	8
156	R:R:I318	R:R:I354	5.89	No	No	11	5	4
157	R:R:I318	R:R:P355	3.39	No	No	11	5	9
158	R:R:I318	R:R:Y398	8.46	No	No	0	5	6
159	R:R:I322	R:R:W319	7.05	No	Yes	0	7	9
160	R:R:H348	R:R:W319	9.52	No	Yes	6	9	9
161	R:R:A351	R:R:W319	11.67	No	Yes	0	9	9
162	R:R:W319	R:R:W352	9.37	Yes	Yes	6	9	9
163	R:R:V321	R:R:W320	3.68	No	Yes	0	9	9
164	R:R:T324	R:R:W320	7.28	Yes	Yes	12	8	9
165	R:R:L399	R:R:W320	3.42	No	Yes	0	8	9
166	R:R:G402	R:R:W320	5.63	No	Yes	12	9	9
167	R:R:W320	R:R:Y444	34.73	Yes	No	0	9	8
168	R:R:T445	R:R:W320	3.64	No	Yes	0	7	9
169	R:R:F347	R:R:I322	15.07	No	No	0	8	7
170	R:R:F440	R:R:L323	3.65	No	Yes	10	9	9
171	R:R:L323	R:R:S441	4.5	Yes	No	0	9	8
172	R:R:G402	R:R:T324	5.46	No	Yes	12	9	8
173	R:R:F405	R:R:T324	5.19	No	Yes	0	8	8
174	R:R:I406	R:R:T324	6.08	No	Yes	0	8	8
175	R:R:L325	R:R:L329	6.92	No	No	0	6	8
176	R:R:F347	R:R:L325	3.65	No	No	0	8	6
177	R:R:F405	R:R:L325	10.96	No	No	0	8	6
178	R:R:F347	R:R:T326	3.89	No	No	0	8	8
179	R:R:A331	R:R:W327	7.78	No	Yes	0	8	9
180	R:R:G409	R:R:W327	4.22	No	Yes	0	9	9
181	R:R:M434	R:R:W327	6.98	Yes	Yes	0	8	9
182	R:R:I437	R:R:W327	4.7	No	Yes	0	8	9
183	R:R:G438	R:R:W327	5.63	No	Yes	0	8	9
184	R:R:F328	R:R:L329	3.65	No	No	0	7	8
185	R:R:F328	R:R:L333	8.53	No	No	0	7	6
186	R:R:A408	R:R:F328	5.55	No	No	0	5	7
187	R:R:L329	R:R:W335	19.36	No	Yes	0	8	8
188	R:R:L333	R:R:W335	3.42	No	Yes	0	6	8
189	R:R:A339	R:R:W335	5.19	No	Yes	0	8	8
190	R:R:I340	R:R:W335	3.52	No	Yes	0	9	8
191	R:R:H343	R:R:W335	7.41	No	Yes	0	6	8
192	R:R:E431	R:R:H337	7.39	No	No	0	8	6
193	R:R:H348	R:R:W352	8.46	No	Yes	6	9	9
194	R:R:I354	R:R:P355	3.39	No	No	11	4	9
195	R:R:K358	R:R:Y398	7.17	No	No	0	7	6
196	R:R:F390	R:R:V361	3.93	Yes	No	0	8	4
197	R:R:I362	R:R:V379	7.68	Yes	No	0	6	8
198	R:R:F390	R:R:I362	12.56	Yes	Yes	4	8	6
199	R:R:L367	R:R:M365	4.24	No	No	0	6	5
200	R:R:A386	R:R:L367	6.3	No	No	0	5	6
201	R:R:F390	R:R:L367	3.65	Yes	No	0	8	6
202	R:R:D369	R:R:N381	9.42	No	No	0	8	7
203	R:R:D369	R:R:Q382	13.05	No	No	0	8	5
204	R:R:D371	R:R:T374	7.23	No	No	0	9	8
205	R:R:D371	R:R:N381	10.77	No	No	0	9	7
206	R:R:L376	R:R:T374	8.84	Yes	No	0	7	8
207	R:R:V379	R:R:Y378	5.05	No	Yes	0	8	6
208	R:R:N381	R:R:Y378	3.49	No	Yes	0	7	6
209	R:R:V391	R:R:Y378	8.83	No	Yes	0	7	6
210	R:R:G380	R:R:L387	3.42	No	Yes	0	9	8
211	R:R:D385	R:R:N383	4.04	No	No	0	2	6
212	R:R:A386	R:R:N383	6.25	No	No	0	5	6
213	R:R:I459	R:R:L384	4.28	No	No	0	6	2
214	R:R:L384	R:R:W462	19.36	No	Yes	0	2	7
215	R:R:L387	R:R:V391	4.47	Yes	No	5	8	7
216	R:R:L387	R:R:Y455	4.69	Yes	Yes	5	8	4
217	R:R:E458	R:R:L387	3.98	Yes	Yes	5	9	8
218	R:R:L387	R:R:W462	3.42	Yes	Yes	5	8	7
219	R:R:I459	R:R:T388	6.08	No	No	0	6	6
220	R:R:V391	R:R:Y455	5.05	No	Yes	5	7	4
221	R:R:V392	R:R:Y455	3.79	No	Yes	0	6	4
222	R:R:I459	R:R:V392	4.61	No	No	0	6	6
223	R:R:P394	R:R:Y398	4.17	No	No	0	9	6
224	R:R:F396	R:R:V400	6.55	No	No	0	2	3
225	R:R:F405	R:R:I401	3.77	No	No	0	8	4
226	R:R:F414	R:R:R417	5.34	No	No	0	5	8
227	R:R:L430	R:R:V435	4.47	Yes	No	0	8	6
228	R:R:E431	R:R:L433	9.28	No	No	0	8	8
229	R:R:E431	R:R:M434	4.06	No	Yes	0	8	8
230	R:R:R432	R:R:V435	6.54	No	No	0	7	6
231	R:R:I437	R:R:L433	7.14	No	No	0	8	8
232	R:R:K436	R:R:W494	4.64	No	No	0	9	9
233	R:R:L443	R:R:V439	4.47	No	No	0	8	5
234	R:R:V439	R:R:W494	3.68	No	No	0	5	9
235	R:R:F440	R:R:W494	18.04	No	No	0	9	9
236	R:R:V487	R:R:Y444	6.31	No	No	0	8	8
237	R:R:P447	R:R:V446	3.53	No	No	0	8	6
238	R:R:I450	R:R:L479	4.28	No	No	2	4	6
239	R:R:I450	R:R:M483	11.66	No	Yes	2	4	9
240	R:R:C454	R:R:V476	3.42	No	No	0	6	6
241	R:R:C454	R:R:K480	6.47	No	Yes	0	6	8
242	R:R:K480	R:R:Y455	19.11	Yes	Yes	0	8	4
243	R:R:F456	R:R:S460	7.93	No	No	0	4	3
244	R:R:N461	R:R:Y457	8.14	No	No	0	5	8
245	R:R:F465	R:R:Y457	4.13	Yes	No	0	8	8
246	R:R:E458	R:R:W462	5.45	Yes	Yes	5	9	7
247	R:R:E458	R:R:F465	19.82	Yes	Yes	0	9	8
248	R:R:E458	R:R:K480	6.75	Yes	Yes	0	9	8
249	R:R:L464	R:R:N461	4.12	No	No	0	1	5
250	R:R:R466	R:R:W462	11	No	Yes	0	4	7
251	R:R:L464	R:R:S468	4.5	No	No	0	1	4
252	R:R:L464	R:R:N473	4.12	No	No	0	1	5
253	R:R:F465	R:R:N473	26.58	Yes	No	0	8	5
254	R:R:E477	R:R:F465	3.5	No	Yes	0	6	8
255	R:R:R466	R:R:Y467	20.58	No	No	0	4	1
256	R:R:D470	R:R:S468	4.42	No	No	0	2	4
257	R:R:D470	R:R:S472	10.31	No	No	0	2	8
258	R:R:E477	R:R:K480	8.1	No	Yes	0	6	8
259	R:R:L479	R:R:M483	4.24	No	Yes	2	6	9
260	R:R:F482	R:R:M483	4.98	Yes	Yes	2	7	9
261	R:R:F482	R:R:L486	4.87	Yes	No	0	7	5
262	R:R:G492	R:R:S491	3.71	No	Yes	0	7	8
263	R:R:I495	R:R:T500	4.56	Yes	No	3	7	8
264	R:R:L501	R:R:Q505	10.65	No	No	0	3	5
265	R:R:N509	R:R:R510	3.62	No	No	0	3	7
266	R:R:N513	R:R:R510	4.82	No	No	0	3	7
267	R:R:N513	R:R:V512	4.43	No	No	0	3	2
268	R:R:M483	R:R:P447	3.35	Yes	No	0	9	8
269	R:R:C200	R:R:K195	3.23	No	No	0	9	5
270	R:R:S484	R:R:V451	3.23	No	No	0	6	7
271	R:R:A330	R:R:M434	3.22	No	Yes	0	8	8
272	R:R:V194	R:R:V291	3.21	No	No	0	5	4
273	R:R:S441	R:R:T324	3.2	No	Yes	0	8	8
274	R:R:A469	R:R:L210	3.15	No	No	0	4	4
275	R:R:A268	R:R:L309	3.15	No	Yes	0	6	6
276	R:R:E289	R:R:P290	3.14	No	No	0	3	3
277	R:R:I305	R:R:V271	3.07	Yes	No	0	7	4
278	R:R:I406	R:R:V442	3.07	No	No	0	8	5
279	R:R:I243	R:R:T503	3.04	No	No	0	6	7
280	R:R:I401	R:R:T397	3.04	No	No	0	4	4
281	R:R:F236	R:R:W496	3.01	Yes	No	0	5	6
282	R:R:M493	R:R:T490	3.01	No	No	0	6	7
283	R:R:L395	R:R:S317	3	No	No	0	7	6
284	R:R:L242	R:R:V238	2.98	No	No	0	5	6
285	R:R:L404	R:R:V400	2.98	No	No	0	4	3
286	R:R:N461	R:R:S460	2.98	No	No	0	5	3
287	R:R:C181	R:R:H182	2.95	No	No	0	9	4
288	R:R:L399	R:R:T403	2.95	No	No	0	8	5
289	R:R:L486	R:R:T490	2.95	No	No	0	5	7
290	R:R:A498	R:R:H502	2.93	No	No	0	4	4
291	R:R:G313	R:R:Y265	2.9	No	Yes	0	5	7
292	R:R:I192	R:R:L202	2.85	No	No	0	4	4
293	R:R:I304	R:R:L308	2.85	No	No	0	5	5
294	R:R:I305	R:R:L309	2.85	Yes	Yes	1	7	6
295	R:R:I305	R:R:L376	2.85	Yes	Yes	1	7	7
296	R:R:I452	R:R:L399	2.85	No	No	0	6	8
297	R:R:L430	R:R:M434	2.83	Yes	Yes	0	8	8
298	R:R:D283	R:R:I293	2.8	No	No	0	4	6
299	R:R:H182	R:R:S183	2.79	No	No	0	4	2
300	R:R:L297	R:R:L363	2.77	Yes	No	0	6	8
301	R:R:L307	R:R:L363	2.77	No	No	0	7	8
302	R:R:L413	R:R:L430	2.77	No	Yes	14	8	8
303	R:R:A208	R:R:Y191	2.67	No	No	0	4	3
304	R:R:A448	R:R:Y444	2.67	No	No	0	8	8
305	R:R:H343	R:R:M342	2.63	No	No	0	6	5
306	R:R:R279	R:R:V275	2.62	No	No	0	3	4
307	R:R:D189	R:R:Q190	2.61	No	No	0	4	3
308	R:R:R247	R:R:T503	2.59	No	No	0	9	7
309	R:R:A315	R:R:W352	2.59	No	Yes	0	9	9
310	R:R:F396	R:R:I452	2.51	No	No	0	2	6
311	R:R:N187	R:R:Y191	2.33	No	No	0	4	3
312	R:R:L410	R:R:W327	2.28	No	Yes	0	7	9
313	R:R:G332	R:R:G409	2.11	No	No	13	7	9
314	R:R:C282	R:R:G205	1.96	Yes	No	0	9	3
315	R:R:C302	R:R:G296	1.96	No	No	0	9	6
316	R:R:A412	R:R:G332	1.95	No	No	13	7	7
317	R:R:A412	R:R:G409	1.95	No	No	13	7	9
318	R:R:A393	R:R:P394	1.87	No	No	0	4	9
319	R:R:G185	R:R:V184	1.84	No	No	0	4	4
320	R:R:G276	R:R:V275	1.84	No	No	0	6	4
321	R:R:G301	R:R:T300	1.82	No	No	0	4	5
322	R:R:G389	R:R:T388	1.82	No	No	0	1	6
323	R:R:A370	R:R:C377	1.81	No	No	0	8	9
324	R:R:G301	R:R:I280	1.76	No	No	0	4	6
325	R:R:C181	R:R:S188	1.72	No	No	0	9	1
326	R:R:E338	R:R:G336	1.64	No	No	0	9	7
327	R:R:A350	R:R:I354	1.62	No	No	0	5	4
328	R:R:S497	R:R:T500	1.6	No	No	0	9	8
329	R:R:A224	R:R:L273	1.58	No	No	0	4	5
330	R:R:A303	R:R:L297	1.58	No	Yes	0	8	6
331	R:R:A235	R:R:N263	1.56	No	No	0	5	5
332	R:R:I221	R:R:V225	1.54	No	No	0	1	4
333	R:R:I270	R:R:T274	1.52	No	No	0	5	3
334	R:R:I450	R:R:T449	1.52	No	No	0	4	5
335	R:R:I360	R:R:I364	1.47	No	No	0	7	7
336	R:R:I416	R:R:K334	1.45	No	No	0	8	8
337	R:R:K334	R:R:L413	1.41	No	No	14	8	8
338	R:R:K334	R:R:L430	1.41	No	Yes	14	8	8
339	R:R:K195	R:R:N199	1.4	No	No	0	5	5
340	R:R:A356	R:R:F311	1.39	No	Yes	0	8	9
341	R:R:D244	R:R:K506	1.38	No	No	0	8	3
342	R:R:D283	R:R:E285	1.3	No	No	0	4	4
343	R:R:H502	R:R:Q505	1.24	No	No	0	4	5
344	R:R:F414	R:R:L410	1.22	No	No	0	5	7
345	R:R:F507	R:R:L511	1.22	No	No	0	5	3
346	R:R:N509	R:R:Y508	1.16	No	No	0	3	3
347	R:R:H343	R:R:Y346	1.09	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R196	14.07	4	0	4
2	R:R:Y206	8.8075	4	1	4
3	R:R:Y211	10.3975	4	0	7
4	R:R:W222	10.54	5	2	8
5	R:R:W226	13.42	4	2	5
6	R:R:F231	6.235	4	0	4
7	R:R:F236	5.69	4	3	5
8	R:R:T240	6.04	4	3	9
9	R:R:F241	7.974	5	8	8
10	R:R:Y262	8.0225	4	0	8
11	R:R:Y265	5.676	5	1	7
12	R:R:Y269	6.07667	6	1	6
13	R:R:R272	6.164	5	1	8
14	R:R:R277	10.466	5	1	6
15	R:R:C282	4.3925	4	0	9
16	R:R:L297	4.7025	4	0	6
17	R:R:I305	3.665	4	1	7
18	R:R:F306	8.8175	4	4	9
19	R:R:L309	4.654	5	1	6
20	R:R:Y310	8.41143	7	4	9
21	R:R:F311	5.1125	4	0	9
22	R:R:W319	12.332	5	6	9
23	R:R:W320	9.73	6	12	9
24	R:R:L323	5.875	4	10	9
25	R:R:T324	5.442	5	12	8
26	R:R:W327	5.265	6	0	9
27	R:R:W335	7.78	5	0	8
28	R:R:W352	6.1075	4	6	9
29	R:R:I362	9.06	4	4	6
30	R:R:E372	7.1025	4	0	6
31	R:R:L376	5.346	5	1	7
32	R:R:Y378	5.766	5	0	6
33	R:R:L387	3.996	5	5	8
34	R:R:F390	6.325	4	4	8
35	R:R:L430	2.87	4	14	8
36	R:R:M434	4.2725	4	0	8
37	R:R:Y455	8.16	4	5	4
38	R:R:E458	9	4	5	9
39	R:R:W462	9.8075	4	5	7
40	R:R:F465	13.5075	4	0	8
41	R:R:K480	10.1075	4	0	8
42	R:R:F482	7.975	4	2	7
43	R:R:M483	6.0575	4	2	9
44	R:R:S491	4.938	5	3	8
45	R:R:I495	5.685	4	3	7
46	R:R:W504	7.6775	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C181	R:R:S188	15.6888	1.72	No	No	0	9	1
2	R:R:L202	R:R:L210	15.6292	4.15	No	No	0	4	4
3	R:R:I192	R:R:L202	28.5929	2.85	No	No	0	4	4
4	R:R:I192	R:R:S188	26.0246	10.84	No	No	0	4	1
5	R:R:G209	R:R:L202	15.4066	5.13	No	No	0	6	4
6	R:R:E372	R:R:G209	16.5825	4.91	Yes	No	0	6	6
7	R:R:E372	R:R:K216	32.6915	8.1	Yes	No	0	6	6
8	R:R:K216	R:R:R277	33.5037	13.61	No	Yes	0	6	6
9	R:R:R277	R:R:Y206	15.4536	14.4	Yes	Yes	1	6	4
10	R:R:E278	R:R:Y206	19.132	6.73	No	Yes	0	5	4
11	R:R:C282	R:R:E278	16.7675	4.56	Yes	No	0	9	5
12	R:R:C282	R:R:P290	12.0386	3.77	Yes	No	0	9	3
13	R:R:E372	R:R:L210	24.2686	5.3	Yes	No	0	6	4
14	R:R:E295	R:R:R196	17.8306	10.47	No	Yes	0	7	4
15	R:R:E295	R:R:K298	18.9031	9.45	No	No	0	7	5
16	R:R:K298	R:R:R366	19.9661	8.66	No	No	0	5	6
17	R:R:L297	R:R:R366	21.0229	8.5	Yes	No	0	6	6
18	R:R:L297	R:R:V368	22.9891	5.96	Yes	No	0	6	8
19	R:R:F306	R:R:V368	24.0208	14.42	Yes	No	0	9	8
20	R:R:F306	R:R:Y310	26.5264	7.22	Yes	Yes	4	9	9
21	R:R:Y310	R:R:Y378	100	7.94	Yes	Yes	0	9	6
22	R:R:L309	R:R:Y378	93.976	3.52	Yes	Yes	0	6	6
23	R:R:L309	R:R:L376	51.3312	5.54	Yes	Yes	1	6	7
24	R:R:L376	R:R:R272	52.5322	3.64	Yes	Yes	1	7	8
25	R:R:R272	R:R:R277	47.5901	13.86	Yes	Yes	1	8	6
26	R:R:E286	R:R:R196	10.2982	24.42	No	Yes	0	2	4
27	R:R:E372	R:R:Y211	13.7038	10.1	Yes	Yes	0	6	7
28	R:R:L373	R:R:Y211	13.0139	21.1	No	Yes	0	8	7
29	R:R:N473	R:R:Y211	11.6247	3.49	No	Yes	0	5	7
30	R:R:L373	R:R:T219	14.6195	8.84	No	No	0	8	5
31	R:R:M223	R:R:T219	16.0902	4.52	No	No	0	6	5
32	R:R:M223	R:R:R272	17.0372	3.72	No	Yes	0	6	8
33	R:R:M223	R:R:Y269	24.6919	7.18	No	Yes	0	6	6
34	R:R:I481	R:R:Y269	29.1856	3.63	No	Yes	0	7	6
35	R:R:L376	R:R:Y269	28.7999	5.86	Yes	Yes	1	7	6
36	R:R:I481	R:R:W222	27.5455	5.87	No	Yes	0	7	8
37	R:R:F482	R:R:W222	17.9968	5.01	Yes	Yes	2	7	8
38	R:R:L485	R:R:Y269	28.9567	5.86	No	Yes	1	8	6
39	R:R:C230	R:R:L485	52.6796	4.76	No	No	0	7	8
40	R:R:C230	R:R:S266	51.5413	5.16	No	No	0	7	8
41	R:R:F231	R:R:S266	50.3967	5.28	Yes	No	0	4	8
42	R:R:F231	R:R:N263	45.7556	10.87	Yes	No	0	4	5
43	R:R:N263	R:R:T234	43.3974	8.77	No	No	0	5	8
44	R:R:S491	R:R:T234	42.2089	4.8	Yes	No	0	8	8
45	R:R:S491	R:R:T237	37.3013	6.4	Yes	No	3	8	8
46	R:R:I495	R:R:T237	36.1567	6.08	Yes	No	3	7	8
47	R:R:F236	R:R:I495	16.8836	7.54	Yes	Yes	3	5	7
48	R:R:I495	R:R:T240	15.5602	4.56	Yes	Yes	3	7	9
49	R:R:F236	R:R:W504	14.3027	7.02	Yes	Yes	3	5	9
50	R:R:T240	R:R:W504	14.4188	9.7	Yes	Yes	3	9	9
51	R:R:K358	R:R:Y310	85.3021	11.94	No	Yes	4	7	9
52	R:R:K358	R:R:Y398	85.7913	7.17	No	No	0	7	6
53	R:R:I318	R:R:Y398	84.3049	8.46	No	No	0	5	6
54	R:R:I318	R:R:P355	82.1004	3.39	No	No	11	5	9
55	R:R:F311	R:R:P355	82.1725	4.33	Yes	No	0	9	9
56	R:R:F311	R:R:W352	64.6681	4.01	Yes	Yes	0	9	9
57	R:R:W319	R:R:W352	61.6263	9.37	Yes	Yes	6	9	9
58	R:R:I322	R:R:W319	59.9548	7.05	No	Yes	0	7	9
59	R:R:F347	R:R:I322	59.3057	15.07	No	No	0	8	7
60	R:R:F347	R:R:L325	58.02	3.65	No	No	0	8	6
61	R:R:L325	R:R:L329	47.6058	6.92	No	No	0	6	8
62	R:R:L329	R:R:W335	44.0246	19.36	No	Yes	0	8	8
63	R:R:I340	R:R:W335	38.9507	3.52	No	Yes	0	9	8
64	R:R:I340	R:R:P251	38.0351	6.77	No	No	0	9	9
65	R:R:P251	R:R:S249	15.5163	7.13	No	No	9	9	6
66	R:R:E252	R:R:S249	14.5881	8.62	No	No	0	9	6
67	R:R:E252	R:R:F248	12.186	4.66	No	No	0	9	8
68	R:R:F241	R:R:F248	10.0129	6.43	Yes	No	8	8	8
69	R:R:I243	R:R:W504	23.5818	10.57	No	Yes	0	6	9
70	R:R:I243	R:R:T503	15.7766	3.04	No	No	0	6	7
71	R:R:R247	R:R:T503	13.1331	2.59	No	No	0	9	7
72	R:R:H337	R:R:P251	21.5937	18.3	No	No	9	6	9
73	R:R:E431	R:R:H337	20.6654	7.39	No	No	0	8	6
74	R:R:F405	R:R:L325	19.3672	10.96	No	No	0	8	6
75	R:R:F405	R:R:T324	16.5167	5.19	No	Yes	0	8	8
76	R:R:S441	R:R:T324	10.0317	3.2	No	Yes	0	8	8
77	R:R:F311	R:R:F312	17.84	10.72	Yes	No	0	9	8
78	R:R:C261	R:R:F312	15.9271	4.19	No	No	0	8	8
79	R:R:C261	R:R:S316	14.9801	3.44	No	No	0	8	8
80	R:R:S316	R:R:Y262	14.3341	7.63	No	Yes	0	8	8
81	R:R:V487	R:R:Y262	12.3961	11.36	No	Yes	0	8	8
82	R:R:Y265	R:R:Y269	16.3316	9.93	Yes	Yes	1	7	6
83	R:R:L309	R:R:Y265	41.2493	8.21	Yes	Yes	1	6	7
84	R:R:V487	R:R:Y444	11.7439	6.31	No	No	0	8	8
85	R:R:W320	R:R:Y444	10.4707	34.73	Yes	No	0	9	8
86	R:R:E431	R:R:M434	17.9498	4.06	No	Yes	0	8	8
87	R:R:F465	R:R:N473	10.6777	26.58	Yes	No	0	8	5
88	R:R:E458	R:R:F465	11.7345	19.82	Yes	Yes	0	9	8
89	R:R:L387	R:R:V391	14.1898	4.47	Yes	No	5	8	7
90	R:R:F482	R:R:M483	10.9662	4.98	Yes	Yes	2	7	9
91	R:R:D220	R:R:R272	14.0738	5.96	No	Yes	1	6	8
92	R:R:D220	R:R:Y206	13.0233	6.9	No	Yes	1	6	4
93	R:R:V391	R:R:Y378	22.9734	8.83	No	Yes	0	7	6
94	R:R:L485	R:R:Y265	24.8518	3.52	No	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6BD4

PDB Summary
PDB	6BD4
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD4
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.4
Date	2018-08-22
D.O.I.	doi.org/10.1038/s41586-018-0447-x

Net Summary
I_min	3.39
Number of Linked Nodes	308
Number of Links	347
Number of Hubs	46
Number of Links mediated by Hubs	168
Number of Communities	14
Number of Nodes involved in Communities	65
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	68091
Length Of Smallest Path	3
Average Path Length	17.1378
Length of Longest Path	41
Minimum Path Strength	1.75
Average Path Strength	7.26027
Maximum Path Strength	23.2
Minimum Path Correlation	0.7
Average Path Correlation	0.936696
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	49.1053
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1012
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • binding • metal ion binding • small molecule binding • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • amide binding • amyloid-beta binding • peptide binding • protein-containing complex binding • ubiquitin protein ligase binding • protein binding • ubiquitin-like protein ligase binding • enzyme binding • Wnt-protein binding • G protein-coupled receptor activity • PDZ domain binding • protein domain specific binding • protein heterodimerization activity • protein dimerization activity • cytokine receptor activity • immune receptor activity • cytokine binding • identical protein binding • protein homodimerization activity • catabolic process • hydrocarbon catabolic process • metabolic process • cellular process • alkane catabolic process • hydrocarbon metabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation
Gene Ontology	Biological Process	• catabolic process • hydrocarbon catabolic process • metabolic process • cellular process • alkane catabolic process • hydrocarbon metabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • signal transduction • Wnt signaling pathway • cell population proliferation • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • response to chemical • cellular response to lipid • multicellular organismal process • system process • sensory perception • nervous system process • sensory perception of sound • sensory perception of mechanical stimulus • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • regulation of cellular component organization • positive regulation of cellular component organization • regulation of developmental process • cellular developmental process • regulation of neuron projection arborization • cell projection organization • plasma membrane bounded cell projection morphogenesis • positive regulation of biological process • cell development • neuron projection development • cell morphogenesis • regulation of cell morphogenesis • cellular component organization • positive regulation of developmental process • neurogenesis • multicellular organism development • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • anatomical structure development • positive regulation of cell projection organization • cellular component organization or biogenesis • regulation of anatomical structure morphogenesis • positive regulation of cellular process • system development • developmental process • plasma membrane bounded cell projection organization • regulation of cell projection organization • positive regulation of neuron projection arborization • nervous system development • generation of neurons • anatomical structure morphogenesis • neuron projection arborization • neuron development • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • sensory organ development • blood vessel morphogenesis • tube development • retina vasculature development in camera-type eye • eye development • animal organ development • retina development in camera-type eye • visual system development • retina vasculature morphogenesis in camera-type eye • vasculature development • circulatory system development • tube morphogenesis • camera-type eye development • retinal blood vessel morphogenesis • sensory system development • blood vessel development • establishment of blood-brain barrier • central nervous system development • angiogenesis • anatomical structure formation involved in morphogenesis • head development • cerebellum vasculature development • brain development • cerebellum development • metencephalon development • cerebellum vasculature morphogenesis • hindbrain development • non-canonical Wnt signaling pathway • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • Norrin signaling pathway • cellular process involved in reproduction in multicellular organism • localization • development of primary sexual characteristics • reproductive structure development • regulation of biological quality • gonad development • luteinization • regulation of hormone levels • lipid transport • establishment of localization • endocrine hormone secretion • lipid export from cell • ovulation cycle process • transport • reproductive process • steroid hormone secretion • sex differentiation • development of primary female sexual characteristics • hormone secretion • developmental process involved in reproduction • progesterone secretion • ovulation cycle • secretion by cell • signal release • rhythmic process • reproductive system development • secretion • female gonad development • multicellular organismal reproductive process • lipid localization • export from cell • cell-cell signaling • female sex differentiation • endocrine process • macromolecule localization • hormone transport • cellular response to growth factor stimulus • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • regulation of vascular endothelial growth factor receptor signaling pathway • cellular response to endogenous stimulus • enzyme-linked receptor protein signaling pathway • regulation of signaling • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • vascular endothelial growth factor receptor signaling pathway • regulation of response to stimulus • regulation of cell communication • response to growth factor • vasculogenesis • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • extracellular matrix-cell signaling • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of biological process • negative regulation of cell adhesion • negative regulation of cellular process • negative regulation of cell-substrate adhesion • Wnt signaling pathway, calcium modulating pathway • behavior • locomotory behavior • locomotion involved in locomotory behavior • positive regulation of nervous system development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of dendrite morphogenesis • positive regulation of cell development • positive regulation of cell morphogenesis • regulation of dendrite development • positive regulation of multicellular organismal process • regulation of neuron projection development • regulation of nervous system development • positive regulation of cell differentiation • dendrite development • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of dendrite morphogenesis • dendrite morphogenesis • cell morphogenesis involved in neuron differentiation • regulation of plasma membrane bounded cell projection organization • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle
Gene Ontology	Cellular Component	• cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • glutamatergic synapse • cilium • cell surface • cell periphery • plasma membrane • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen
SCOP2	Domain Identifier	• Rubredoxin-like
SCOP2	Family Identifier	• Rubredoxin-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9ULV1
Sequence	>6BD4_Chain_R C H S V G T N S D Q Y I W V K R S L N C V L K C G Y D A G L Y S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D S S R F S Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G R E R I S C D F E E A A E P V L I Q E G L K N T G C A I I F L L L Y F F G M A S S I W W V I L T L T W F L A A G L K W G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R L V D A D E L T G L C Y V G N Q N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N D K L E R L M V K I G V F S V L Y T V P A T I V I A C Y F Y E I S N W A L F R Y S A D D S N M A V E M L K I F M S L L V G I T S G M W I W S A K T L H T W Q K F Y N R L V N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WM9	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	DVL-2	3.53	2024-09-11	doi.org/10.1038/s41467-024-52174-z
	8WMA	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	DVL-2	3.47	2024-09-11	doi.org/10.1038/s41467-024-52174-z

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