psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E467	L:L:S418	2.87	No	No	0	0	0
2	L:L:G468	L:L:V419	3.68	No	No	0	0	0
3	L:L:F469	L:L:V419	2.62	Yes	No	0	0	0
4	L:L:A424	L:L:D422	3.09	No	No	0	0	0
5	L:L:D422	L:L:S425	4.42	No	No	0	0	0
6	L:L:A424	L:L:K428	3.21	No	No	0	0	0
7	L:L:V426	L:L:Y478	8.83	No	Yes	0	0	0
8	L:L:L487	L:L:T427	10.32	No	No	0	0	0
9	L:L:L437	L:L:M430	5.65	Yes	No	1	0	0
10	L:L:M430	L:L:W461	9.31	No	Yes	1	0	0
11	L:L:F505	L:L:M430	3.73	No	No	1	0	0
12	L:L:A432	L:L:P433	1.87	No	No	0	0	0
13	L:L:E434	L:L:P433	4.72	No	No	0	0	0
14	L:L:G436	L:L:S435	3.71	No	No	1	0	0
15	L:L:S435	L:L:W461	8.65	No	Yes	1	0	0
16	L:L:G436	L:L:W461	4.22	No	Yes	1	0	0
17	L:L:F453	L:L:L437	17.05	Yes	Yes	1	0	0
18	L:L:F505	L:L:L437	2.44	No	Yes	1	0	0
19	L:L:E438	L:L:R440	22.1	No	No	0	0	0
20	L:L:N451	L:L:V439	4.43	No	No	0	0	0
21	L:L:D441	L:L:T448	4.34	No	No	0	0	0
22	L:L:L454	L:L:R442	4.86	No	Yes	6	0	0
23	L:L:R442	L:L:Y502	13.38	Yes	Yes	6	0	0
24	L:L:R442	R:R:H337	3.39	Yes	No	6	0	6
25	L:L:R442	R:R:E338	5.82	Yes	No	6	0	9
26	L:L:L445	L:L:W444	5.69	No	Yes	0	0	0
27	L:L:W444	L:L:Y502	2.89	Yes	Yes	0	0	0
28	L:L:W444	R:R:K334	3.48	Yes	No	0	0	8
29	L:L:L445	R:R:L430	2.77	No	No	0	0	8
30	L:L:K446	R:R:K429	4.31	No	No	0	0	8
31	L:L:I449	L:L:P450	3.39	No	No	0	0	0
32	L:L:A452	L:L:I449	3.25	No	No	0	0	0
33	L:L:I449	L:L:Y502	2.42	No	Yes	0	0	0
34	L:L:F453	L:L:V458	2.62	Yes	No	0	0	0
35	L:L:F453	L:L:I488	7.54	Yes	No	1	0	0
36	L:L:F453	L:L:F505	15	Yes	No	1	0	0
37	L:L:D457	L:L:L454	8.14	No	No	0	0	0
38	L:L:L454	L:L:Y502	3.52	No	Yes	6	0	0
39	L:L:G455	L:L:V458	3.68	No	No	0	0	0
40	L:L:G455	L:L:Y503	2.9	No	Yes	0	0	0
41	L:L:E499	L:L:S456	4.31	No	No	0	0	0
42	L:L:L462	L:L:V458	2.98	No	No	0	0	0
43	L:L:D460	L:L:V459	2.92	No	Yes	0	0	0
44	L:L:F497	L:L:V459	2.62	Yes	Yes	1	0	0
45	L:L:E499	L:L:V459	7.13	No	Yes	1	0	0
46	L:L:L462	L:L:W461	2.28	No	Yes	0	0	0
47	L:L:H465	L:L:W461	16.93	No	Yes	0	0	0
48	L:L:L462	L:L:Y478	3.52	No	Yes	0	0	0
49	L:L:H464	L:L:Y463	6.53	No	No	0	0	0
50	L:L:E471	L:L:Y463	2.24	No	No	0	0	0
51	L:L:F469	L:L:V466	17.04	Yes	No	0	0	0
52	L:L:E467	L:L:G468	3.27	No	No	0	0	0
53	L:L:F469	L:L:P470	4.33	Yes	No	0	0	0
54	L:L:F469	L:L:Y478	11.35	Yes	Yes	0	0	0
55	L:L:P470	L:L:R473	4.32	No	No	12	0	0
56	L:L:E474	L:L:P470	17.29	No	No	12	0	0
57	L:L:E471	L:L:R473	6.98	No	No	0	0	0
58	L:L:E474	L:L:R473	16.28	No	No	12	0	0
59	L:L:E474	L:L:R476	3.49	No	No	0	0	0
60	L:L:K477	L:L:R476	7.43	No	No	0	0	0
61	L:L:L482	L:L:Y478	4.69	No	Yes	0	0	0
62	L:L:A479	L:L:F497	5.55	No	Yes	0	0	0
63	L:L:G481	L:L:S480	1.86	No	No	0	0	0
64	L:L:F497	L:L:S480	2.64	Yes	No	0	0	0
65	L:L:G481	L:L:K484	5.23	No	No	0	0	0
66	L:L:L482	L:L:L487	4.15	No	No	0	0	0
67	L:L:I488	L:L:L483	2.85	No	No	1	0	0
68	L:L:F497	L:L:L483	6.09	Yes	No	1	0	0
69	L:L:L483	L:L:Y503	5.86	No	Yes	1	0	0
70	L:L:A485	L:L:L487	3.15	No	No	0	0	0
71	L:L:I488	L:L:Y503	8.46	No	Yes	1	0	0
72	L:L:R489	L:L:V504	3.92	No	No	0	0	0
73	L:L:H490	L:L:V492	5.54	Yes	No	0	0	0
74	L:L:H490	L:L:K494	14.41	Yes	No	1	0	0
75	L:L:C501	L:L:H490	4.42	No	Yes	1	0	0
76	L:L:H490	L:L:Y503	7.62	Yes	Yes	1	0	0
77	L:L:C501	L:L:K494	4.85	No	No	1	0	0
78	L:L:I495	L:L:T496	3.04	No	No	0	0	0
79	L:L:E499	L:L:F497	2.33	No	Yes	1	0	0
80	L:L:F497	L:L:Y503	9.28	Yes	Yes	1	0	0
81	L:L:Q500	L:L:S498	7.22	No	No	0	0	0
82	L:L:Q500	R:R:W335	2.19	No	Yes	13	0	8
83	L:L:Q500	R:R:A339	3.03	No	No	13	0	8
84	L:L:C501	L:L:Y503	5.38	No	Yes	1	0	0
85	L:L:Y502	R:R:G336	5.79	Yes	No	0	0	7
86	L:L:Y502	R:R:H337	2.18	Yes	No	6	0	6
87	L:L:Y502	R:R:E338	3.37	Yes	No	6	0	9
88	R:R:Q190	R:R:Y191	7.89	Yes	No	7	3	3
89	R:R:L202	R:R:Q190	11.98	Yes	Yes	7	4	3
90	R:R:K203	R:R:Q190	6.78	No	Yes	0	5	3
91	R:R:G209	R:R:Q190	6.58	No	Yes	0	6	3
92	R:R:L210	R:R:Q190	10.65	Yes	Yes	7	4	3
93	R:R:C200	R:R:Y191	4.03	No	No	0	9	3
94	R:R:L202	R:R:Y191	3.52	Yes	No	7	4	3
95	R:R:I192	R:R:V201	4.61	Yes	Yes	8	4	6
96	R:R:A287	R:R:I192	3.25	No	Yes	0	2	4
97	R:R:E289	R:R:I192	4.1	No	Yes	0	3	4
98	R:R:I192	R:R:V291	7.68	Yes	Yes	8	4	4
99	R:R:L198	R:R:W193	6.83	No	No	0	3	3
100	R:R:C200	R:R:W193	2.61	No	No	0	9	3
101	R:R:S197	R:R:V194	3.23	No	Yes	0	4	5
102	R:R:E286	R:R:V194	12.84	No	Yes	8	2	5
103	R:R:V194	R:R:V291	3.21	Yes	Yes	8	5	4
104	R:R:E295	R:R:R196	5.82	No	No	0	7	4
105	R:R:N199	R:R:V201	5.91	No	Yes	0	5	6
106	R:R:V201	R:R:V291	8.02	Yes	Yes	8	6	4
107	R:R:Q294	R:R:V201	5.73	No	Yes	0	6	6
108	R:R:L202	R:R:L210	2.77	Yes	Yes	7	4	4
109	R:R:E372	R:R:L202	5.3	No	Yes	7	6	4
110	R:R:A208	R:R:K203	3.21	No	No	0	4	5
111	R:R:C204	R:R:C282	7.28	No	No	0	8	9
112	R:R:A208	R:R:G205	1.95	No	No	0	4	3
113	R:R:C282	R:R:G205	1.96	No	No	0	9	3
114	R:R:K216	R:R:Y206	2.39	No	Yes	3	6	4
115	R:R:D220	R:R:Y206	5.75	No	Yes	3	6	4
116	R:R:R277	R:R:Y206	6.17	Yes	Yes	3	6	4
117	R:R:E278	R:R:Y206	4.49	No	Yes	3	5	4
118	R:R:D207	R:R:R213	15.48	No	No	0	4	1
119	R:R:A208	R:R:G209	1.95	No	No	0	4	6
120	R:R:L210	R:R:Y211	2.34	Yes	Yes	0	4	7
121	R:R:E372	R:R:L210	7.95	No	Yes	7	6	4
122	R:R:K216	R:R:Y211	3.58	No	Yes	0	6	7
123	R:R:L373	R:R:Y211	8.21	No	Yes	0	8	7
124	R:R:A469	R:R:Y211	2.67	No	Yes	0	4	7
125	R:R:N473	R:R:Y211	2.33	No	Yes	0	5	7
126	R:R:S212	R:R:S214	4.89	No	No	0	4	3
127	R:R:K216	R:R:R277	7.43	No	Yes	3	6	6
128	R:R:F218	R:R:I221	2.51	No	No	0	5	1
129	R:R:F218	R:R:W222	5.01	No	Yes	0	5	8
130	R:R:F218	R:R:M474	4.98	No	No	0	5	4
131	R:R:D220	R:R:R272	10.72	No	Yes	3	6	8
132	R:R:D220	R:R:R277	4.76	No	Yes	3	6	6
133	R:R:I221	R:R:V225	3.07	No	No	0	1	4
134	R:R:W222	R:R:W226	21.56	Yes	No	14	8	5
135	R:R:M478	R:R:W222	19.78	No	Yes	0	6	8
136	R:R:F482	R:R:W222	2	No	Yes	14	7	8
137	R:R:M223	R:R:Y269	4.79	Yes	No	0	6	6
138	R:R:M223	R:R:R272	3.72	Yes	Yes	3	6	8
139	R:R:M223	R:R:T374	3.01	Yes	Yes	3	6	8
140	R:R:L376	R:R:M223	2.83	No	Yes	3	7	6
141	R:R:F482	R:R:W226	18.04	No	No	14	7	5
142	R:R:I489	R:R:W226	2.35	No	No	0	8	5
143	R:R:A227	R:R:Y269	2.67	No	No	0	7	6
144	R:R:C230	R:R:S266	3.44	Yes	No	0	7	8
145	R:R:C230	R:R:L485	3.17	Yes	No	0	7	8
146	R:R:C230	R:R:G488	1.96	Yes	No	0	7	9
147	R:R:F231	R:R:N263	7.25	Yes	Yes	15	4	5
148	R:R:F231	R:R:S266	5.28	Yes	No	0	4	8
149	R:R:F231	R:R:I267	3.77	Yes	No	15	4	4
150	R:R:S259	R:R:T234	4.8	No	No	0	8	8
151	R:R:N263	R:R:T234	4.39	Yes	No	0	5	8
152	R:R:S491	R:R:T234	3.2	No	No	0	8	8
153	R:R:F236	R:R:T240	7.78	Yes	Yes	5	5	9
154	R:R:F236	R:R:I495	2.51	Yes	Yes	5	5	7
155	R:R:F236	R:R:T500	2.59	Yes	No	5	5	8
156	R:R:F236	R:R:W504	14.03	Yes	Yes	5	5	9
157	R:R:T237	R:R:T240	3.14	No	Yes	5	8	9
158	R:R:S259	R:R:T237	7.99	No	No	0	8	8
159	R:R:I495	R:R:T237	7.6	Yes	No	5	7	8
160	R:R:S259	R:R:V238	4.85	No	No	0	8	6
161	R:R:L239	R:R:W504	4.56	No	Yes	0	5	9
162	R:R:I495	R:R:T240	3.04	Yes	Yes	5	7	9
163	R:R:T240	R:R:W504	6.06	Yes	Yes	5	9	9
164	R:R:F241	R:R:S245	3.96	No	No	0	8	6
165	R:R:F241	R:R:I256	18.84	No	No	0	8	7
166	R:R:I243	R:R:W504	3.52	No	Yes	0	6	9
167	R:R:D244	R:R:S246	5.89	No	No	0	8	4
168	R:R:F248	R:R:R247	2.14	No	No	0	8	9
169	R:R:K499	R:R:R247	9.9	No	No	0	9	9
170	R:R:F248	R:R:I256	3.77	No	No	0	8	7
171	R:R:R253	R:R:Y250	4.12	No	Yes	2	9	9
172	R:R:P254	R:R:Y250	2.78	Yes	Yes	2	8	9
173	R:R:T326	R:R:Y250	3.75	Yes	Yes	2	8	9
174	R:R:I340	R:R:Y250	6.04	No	Yes	2	9	9
175	R:R:F347	R:R:Y250	8.25	Yes	Yes	2	8	9
176	R:R:P251	R:R:T326	3.5	No	Yes	2	9	8
177	R:R:P251	R:R:W327	8.11	No	Yes	2	9	9
178	R:R:A330	R:R:P251	1.87	No	No	2	8	9
179	R:R:E252	R:R:W494	2.18	No	Yes	0	9	9
180	R:R:P254	R:R:R253	2.88	Yes	No	2	8	9
181	R:R:F257	R:R:R253	3.21	No	No	2	7	9
182	R:R:P254	R:R:W319	5.4	Yes	Yes	2	8	9
183	R:R:L323	R:R:P254	6.57	No	Yes	0	9	8
184	R:R:I255	R:R:L323	4.28	No	No	0	8	9
185	R:R:I255	R:R:W494	17.62	No	Yes	0	8	9
186	R:R:F257	R:R:W319	14.03	No	Yes	2	7	9
187	R:R:F257	R:R:H348	5.66	No	No	2	7	9
188	R:R:L258	R:R:S316	3	No	No	0	7	8
189	R:R:C261	R:R:F312	4.19	No	No	0	8	8
190	R:R:Y262	R:R:Y265	2.98	No	Yes	0	8	7
191	R:R:S316	R:R:Y262	10.17	No	No	0	8	8
192	R:R:V487	R:R:Y262	7.57	Yes	No	0	8	8
193	R:R:I267	R:R:N263	2.83	No	Yes	15	4	5
194	R:R:F312	R:R:I264	20.09	No	No	0	8	5
195	R:R:Y265	R:R:Y269	9.93	Yes	No	0	7	6
196	R:R:L309	R:R:Y265	5.86	Yes	Yes	0	6	7
197	R:R:S484	R:R:Y265	5.09	No	Yes	0	6	7
198	R:R:A268	R:R:L308	3.15	No	No	0	6	5
199	R:R:A268	R:R:L309	3.15	No	Yes	0	6	6
200	R:R:L273	R:R:R272	8.5	No	Yes	0	5	8
201	R:R:R272	R:R:R277	9.6	Yes	Yes	3	8	6
202	R:R:R279	R:R:V275	9.15	No	Yes	0	3	4
203	R:R:I280	R:R:V275	7.68	No	Yes	0	6	4
204	R:R:E278	R:R:R277	2.33	No	Yes	3	5	6
205	R:R:I280	R:R:I305	2.94	No	No	0	6	7
206	R:R:G375	R:R:S281	3.71	No	No	0	9	7
207	R:R:C282	R:R:P290	3.77	No	No	0	9	3
208	R:R:E286	R:R:V291	11.41	No	Yes	8	2	4
209	R:R:A288	R:R:E289	4.53	No	No	0	2	3
210	R:R:L292	R:R:Q294	2.66	No	No	0	5	6
211	R:R:A370	R:R:L292	4.73	No	No	0	8	5
212	R:R:C302	R:R:G296	1.96	No	No	0	9	6
213	R:R:L297	R:R:L363	4.15	Yes	No	0	6	8
214	R:R:L297	R:R:R366	8.5	Yes	No	0	6	6
215	R:R:L297	R:R:V368	4.47	Yes	No	0	6	8
216	R:R:N299	R:R:T300	2.92	No	No	0	7	5
217	R:R:I304	R:R:T300	3.04	No	No	0	5	5
218	R:R:C302	R:R:C377	7.28	No	No	0	9	9
219	R:R:I304	R:R:L308	2.85	No	No	0	5	5
220	R:R:I305	R:R:L309	2.85	No	Yes	0	7	6
221	R:R:F306	R:R:I362	6.28	No	No	0	9	6
222	R:R:F306	R:R:L363	3.65	No	No	0	9	8
223	R:R:F306	R:R:V368	9.18	No	No	0	9	8
224	R:R:L309	R:R:Y378	4.69	Yes	Yes	0	6	6
225	R:R:M314	R:R:Y310	3.59	No	Yes	0	8	9
226	R:R:I362	R:R:Y310	7.25	No	Yes	9	6	9
227	R:R:Y310	R:R:Y378	3.97	Yes	Yes	9	9	6
228	R:R:V379	R:R:Y310	2.52	No	Yes	9	8	9
229	R:R:F390	R:R:Y310	5.16	No	Yes	9	8	9
230	R:R:F311	R:R:F312	5.36	No	No	0	9	8
231	R:R:F311	R:R:W352	3.01	No	Yes	0	9	9
232	R:R:F311	R:R:P355	2.89	No	No	0	9	9
233	R:R:G313	R:R:S316	1.86	No	No	0	5	8
234	R:R:L395	R:R:M314	2.83	No	No	0	7	8
235	R:R:A315	R:R:W352	2.59	No	Yes	0	9	9
236	R:R:S317	R:R:Y398	6.36	No	Yes	0	6	6
237	R:R:S317	R:R:Y444	2.54	No	Yes	0	6	8
238	R:R:I318	R:R:I354	4.42	No	No	0	5	4
239	R:R:I318	R:R:Y398	7.25	No	Yes	0	5	6
240	R:R:H348	R:R:W319	6.35	No	Yes	2	9	9
241	R:R:A351	R:R:W319	6.48	No	Yes	0	9	9
242	R:R:W319	R:R:W352	6.56	Yes	Yes	2	9	9
243	R:R:T324	R:R:W320	7.28	Yes	Yes	10	8	9
244	R:R:G402	R:R:W320	4.22	No	Yes	10	9	9
245	R:R:F440	R:R:W320	6.01	Yes	Yes	10	9	9
246	R:R:W320	R:R:Y444	27.01	Yes	Yes	10	9	8
247	R:R:V321	R:R:Y398	3.79	No	Yes	0	9	6
248	R:R:F347	R:R:I322	3.77	Yes	No	0	8	7
249	R:R:L323	R:R:W327	4.56	No	Yes	0	9	9
250	R:R:G402	R:R:T324	5.46	No	Yes	10	9	8
251	R:R:F405	R:R:T324	2.59	Yes	Yes	0	8	8
252	R:R:I406	R:R:T324	4.56	No	Yes	0	8	8
253	R:R:F405	R:R:L325	3.65	Yes	No	0	8	6
254	R:R:I340	R:R:T326	3.04	No	Yes	2	9	8
255	R:R:F347	R:R:T326	2.59	Yes	Yes	2	8	8
256	R:R:A330	R:R:W327	2.59	No	Yes	2	8	9
257	R:R:L433	R:R:W327	5.69	No	Yes	2	8	9
258	R:R:I437	R:R:W327	10.57	Yes	Yes	2	8	9
259	R:R:F328	R:R:G332	3.01	Yes	No	0	7	7
260	R:R:F328	R:R:L333	3.65	Yes	No	0	7	6
261	R:R:F328	R:R:F405	5.36	Yes	Yes	0	7	8
262	R:R:L329	R:R:W335	7.97	No	Yes	0	8	8
263	R:R:A331	R:R:G332	1.95	No	No	0	8	7
264	R:R:A331	R:R:L413	3.15	No	No	0	8	8
265	R:R:A412	R:R:G332	1.95	No	No	0	7	7
266	R:R:L333	R:R:W335	3.42	No	Yes	0	6	8
267	R:R:I416	R:R:K334	5.82	No	No	0	8	8
268	R:R:A339	R:R:W335	6.48	No	Yes	13	8	8
269	R:R:E338	R:R:H337	19.69	No	No	6	9	6
270	R:R:F347	R:R:I340	2.51	Yes	No	2	8	9
271	R:R:H343	R:R:M342	3.94	No	No	0	6	5
272	R:R:H348	R:R:W352	7.41	No	Yes	2	9	9
273	R:R:I354	R:R:P355	3.39	No	No	0	4	9
274	R:R:I354	R:R:K358	4.36	No	No	0	4	7
275	R:R:F390	R:R:I362	6.28	No	No	9	8	6
276	R:R:L367	R:R:M365	7.07	No	No	0	6	5
277	R:R:D369	R:R:Q382	9.14	No	No	0	8	5
278	R:R:D371	R:R:T374	10.12	No	Yes	0	9	8
279	R:R:E477	R:R:L373	2.65	No	No	0	6	8
280	R:R:L376	R:R:T374	4.42	No	Yes	3	7	8
281	R:R:V379	R:R:Y378	3.79	No	Yes	9	8	6
282	R:R:N381	R:R:Y378	4.65	No	Yes	0	7	6
283	R:R:G380	R:R:V379	1.84	No	No	0	9	8
284	R:R:A386	R:R:G380	1.95	No	No	0	5	9
285	R:R:D385	R:R:N383	4.04	No	No	0	2	6
286	R:R:A386	R:R:N383	4.69	No	No	0	5	6
287	R:R:L384	R:R:W462	23.92	No	No	0	2	7
288	R:R:L387	R:R:V391	4.47	No	No	11	8	7
289	R:R:L387	R:R:Y455	3.52	No	Yes	11	8	4
290	R:R:L387	R:R:W462	2.28	No	No	0	8	7
291	R:R:V391	R:R:Y455	6.31	No	Yes	11	7	4
292	R:R:A393	R:R:P394	1.87	No	No	0	4	9
293	R:R:P394	R:R:Y398	5.56	No	Yes	0	9	6
294	R:R:F396	R:R:V400	7.87	No	No	0	2	3
295	R:R:L404	R:R:V400	2.98	No	No	0	4	3
296	R:R:F405	R:R:I401	2.51	Yes	No	0	8	4
297	R:R:I406	R:R:I437	2.94	No	Yes	0	8	8
298	R:R:A408	R:R:G409	1.95	No	No	0	5	9
299	R:R:L410	R:R:L413	2.77	No	No	0	7	8
300	R:R:L413	R:R:M434	2.83	No	No	0	8	8
301	R:R:Q421	R:R:R417	3.5	No	Yes	16	6	8
302	R:R:R417	R:R:T427	11.64	Yes	No	16	8	6
303	R:R:L430	R:R:R417	4.86	No	Yes	0	8	8
304	R:R:E431	R:R:R417	10.47	No	Yes	0	8	8
305	R:R:Q421	R:R:T427	2.83	No	No	16	6	6
306	R:R:K426	R:R:T425	7.51	No	No	0	7	5
307	R:R:D428	R:R:K429	4.15	No	No	0	4	8
308	R:R:D428	R:R:R432	7.15	No	No	0	4	7
309	R:R:L430	R:R:M434	7.07	No	No	0	8	8
310	R:R:E431	R:R:M434	2.71	No	No	0	8	8
311	R:R:I437	R:R:L433	2.85	Yes	No	2	8	8
312	R:R:K436	R:R:W494	5.8	No	Yes	0	9	9
313	R:R:G438	R:R:S441	3.71	No	No	0	8	8
314	R:R:M493	R:R:V439	3.04	No	No	0	6	5
315	R:R:F440	R:R:Y444	2.06	Yes	Yes	10	9	8
316	R:R:F440	R:R:M493	3.73	Yes	No	0	9	6
317	R:R:F440	R:R:W494	5.01	Yes	Yes	0	9	9
318	R:R:L443	R:R:T490	11.79	No	No	0	8	7
319	R:R:V487	R:R:Y444	2.52	Yes	Yes	0	8	8
320	R:R:P447	R:R:V446	3.53	No	No	0	8	6
321	R:R:P447	R:R:V487	3.53	No	Yes	0	8	8
322	R:R:I450	R:R:M483	8.75	No	No	0	4	9
323	R:R:V451	R:R:Y455	2.52	No	Yes	11	7	4
324	R:R:K480	R:R:V451	4.55	No	No	11	8	7
325	R:R:F456	R:R:I452	3.77	No	Yes	0	4	6
326	R:R:C454	R:R:K480	3.23	No	No	0	6	8
327	R:R:K480	R:R:Y455	21.5	No	Yes	11	8	4
328	R:R:N461	R:R:Y457	8.14	Yes	No	4	5	8
329	R:R:F465	R:R:Y457	6.19	Yes	No	4	8	8
330	R:R:V476	R:R:Y457	5.05	No	No	4	6	8
331	R:R:E458	R:R:F465	18.66	No	Yes	4	9	8
332	R:R:E458	R:R:R466	5.82	No	Yes	4	9	4
333	R:R:E458	R:R:E477	3.81	No	No	0	9	6
334	R:R:N461	R:R:S460	2.98	Yes	No	0	5	3
335	R:R:L464	R:R:N461	5.49	Yes	Yes	4	1	5
336	R:R:F465	R:R:N461	2.42	Yes	Yes	4	8	5
337	R:R:R466	R:R:W462	11	Yes	No	0	4	7
338	R:R:F465	R:R:L464	7.31	Yes	Yes	4	8	1
339	R:R:L464	R:R:N473	4.12	Yes	No	4	1	5
340	R:R:F465	R:R:R466	5.34	Yes	Yes	4	8	4
341	R:R:F465	R:R:N473	20.54	Yes	No	4	8	5
342	R:R:F465	R:R:V476	7.87	Yes	No	4	8	6
343	R:R:R466	R:R:Y467	2.06	Yes	No	0	4	1
344	R:R:M474	R:R:M478	2.89	No	No	0	4	6
345	R:R:L479	R:R:M483	5.65	No	No	0	6	9
346	R:R:F482	R:R:L486	2.44	No	No	0	7	5
347	R:R:G488	R:R:V487	1.84	No	Yes	0	9	8
348	R:R:G488	R:R:S491	3.71	No	No	0	9	8
349	R:R:G492	R:R:S491	1.86	No	No	0	7	8
350	R:R:G492	R:R:W496	5.63	No	No	0	7	6
351	R:R:I495	R:R:W496	5.87	Yes	No	0	7	6
352	R:R:K499	R:R:S497	4.59	No	No	0	9	9
353	R:R:S497	R:R:T500	3.2	No	No	0	9	8
354	R:R:A498	R:R:H502	2.93	No	No	0	4	4
355	R:R:T500	R:R:W504	2.43	No	Yes	5	8	9
356	R:R:W504	R:R:Y508	7.72	Yes	No	0	9	3
357	R:R:N509	R:R:Q505	13.2	No	No	0	3	5
358	R:R:K506	R:R:R510	18.56	No	No	0	3	7
359	R:R:F507	R:R:Y508	4.13	No	No	0	5	3
360	R:R:F507	R:R:L511	3.65	No	No	0	5	3
361	R:R:G301	R:R:T300	1.82	No	No	0	4	5
362	R:R:G375	R:R:T374	1.82	No	Yes	0	9	8
363	R:R:G389	R:R:T388	1.82	No	No	0	1	6
364	R:R:A370	R:R:C377	1.81	No	No	0	8	9
365	R:R:G296	R:R:I293	1.76	No	No	0	6	6
366	R:R:G438	R:R:I437	1.76	No	Yes	0	8	8
367	L:L:A432	L:L:S435	1.71	No	No	0	0	0
368	R:R:A215	R:R:S212	1.71	No	No	0	6	4
369	R:R:C377	R:R:V368	1.71	No	No	0	9	8
370	L:L:A452	L:L:V504	1.7	No	No	0	0	0
371	L:L:A475	L:L:V459	1.7	No	Yes	0	0	0
372	L:L:D507	L:L:G506	1.68	No	No	0	0	0
373	R:R:C230	R:R:I489	1.64	Yes	No	0	7	8
374	R:R:S344	R:R:S345	1.63	No	No	0	8	6
375	R:R:S441	R:R:V442	1.62	No	No	0	8	5
376	R:R:S472	R:R:V476	1.62	No	No	0	8	6
377	L:L:D441	L:L:P450	1.61	No	No	0	0	0
378	R:R:A215	R:R:M474	1.61	No	No	0	6	4
379	L:L:S425	L:L:T421	1.6	No	No	0	0	0
380	R:R:V271	R:R:V275	1.6	No	Yes	0	4	4
381	R:R:V357	R:R:V361	1.6	No	No	0	4	4
382	R:R:V435	R:R:V439	1.6	No	No	0	6	5
383	L:L:T421	L:L:V426	1.59	No	No	0	0	0
384	L:L:T491	L:L:V492	1.59	No	No	0	0	0
385	R:R:T274	R:R:V275	1.59	No	Yes	0	3	4
386	R:R:C454	R:R:L479	1.59	No	No	0	6	6
387	R:R:A224	R:R:L273	1.58	No	No	0	4	5
388	R:R:A303	R:R:L297	1.58	No	Yes	0	8	6
389	R:R:T219	R:R:T374	1.57	No	Yes	0	5	8
390	R:R:A235	R:R:N263	1.56	No	Yes	0	5	5
391	R:R:A370	R:R:D369	1.54	No	No	0	8	8
392	R:R:I459	R:R:V392	1.54	No	No	0	6	6
393	L:L:V492	R:R:K334	1.52	No	No	0	0	8
394	R:R:M260	R:R:V238	1.52	No	No	0	4	6
395	R:R:I243	R:R:T503	1.52	No	No	0	6	7
396	R:R:I481	R:R:T374	1.52	No	Yes	0	7	8
397	R:R:I401	R:R:T397	1.52	No	No	0	4	4
398	R:R:I452	R:R:T449	1.52	Yes	No	0	6	5
399	L:L:M443	L:L:T448	1.51	No	No	0	0	0
400	R:R:F328	R:R:G409	1.51	Yes	No	0	7	9
401	L:L:T448	R:R:K429	1.5	No	No	0	0	8
402	L:L:G506	L:L:R489	1.5	No	No	0	0	0
403	L:L:K494	L:L:T496	1.5	No	No	0	0	0
404	R:R:L464	R:R:S468	1.5	Yes	No	0	1	4
405	L:L:L437	L:L:V439	1.49	Yes	No	0	0	0
406	R:R:L229	R:R:V225	1.49	No	No	0	5	4
407	R:R:L242	R:R:V238	1.49	No	No	0	5	6
408	R:R:L307	R:R:T359	1.47	No	No	0	7	8
409	R:R:L363	R:R:T359	1.47	No	No	0	8	8
410	R:R:I360	R:R:I364	1.47	No	No	0	7	7
411	R:R:L399	R:R:T403	1.47	No	No	0	8	5
412	R:R:L399	R:R:T445	1.47	No	No	0	8	7
413	R:R:L399	R:R:T449	1.47	No	No	0	8	5
414	R:R:D470	R:R:S468	1.47	No	No	0	2	4
415	R:R:L486	R:R:T490	1.47	No	No	0	5	7
416	L:L:I447	R:R:L420	1.43	No	No	0	0	6
417	R:R:I452	R:R:L395	1.43	Yes	No	0	6	7
418	R:R:K415	R:R:N419	1.4	No	No	0	7	5
419	R:R:K422	R:R:N419	1.4	No	No	0	4	5
420	L:L:H420	L:L:S418	1.39	No	No	0	0	0
421	R:R:L367	R:R:N383	1.37	No	No	0	6	6
422	R:R:D470	R:R:D471	1.33	No	No	0	2	1
423	R:R:R196	R:R:V194	1.31	No	Yes	0	4	5
424	R:R:F390	R:R:V361	1.31	No	No	0	8	4
425	R:R:S344	R:R:Y250	1.27	No	Yes	0	8	9
426	R:R:F231	R:R:I232	1.26	Yes	No	0	4	3
427	R:R:F396	R:R:I452	1.26	No	Yes	0	2	6
428	R:R:S233	R:R:W496	1.24	No	No	0	8	6
429	L:L:N493	L:L:R489	1.21	No	No	0	0	0
430	L:L:I447	L:L:W444	1.17	No	Yes	0	0	0
431	R:R:D207	R:R:Y206	1.15	No	Yes	0	4	4
432	R:R:Q505	R:R:Y508	1.13	No	No	0	5	3
433	R:R:E341	R:R:Y250	1.12	No	Yes	0	7	9
434	R:R:H343	R:R:Y346	1.09	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L437	6.6575	4	1	0
2	L:L:R442	6.8625	4	6	0
3	L:L:W444	3.3075	4	0	0
4	L:L:F453	10.5525	4	1	0
5	L:L:V459	3.5925	4	1	0
6	L:L:W461	8.278	5	1	0
7	L:L:F469	8.835	4	0	0
8	L:L:Y478	7.0975	4	0	0
9	L:L:H490	7.9975	4	1	0
10	L:L:F497	4.75167	6	1	0
11	L:L:Y502	4.79286	7	6	0
12	L:L:Y503	6.58333	6	1	0
13	R:R:Q190	8.776	5	7	3
14	R:R:I192	4.91	4	8	4
15	R:R:V194	5.1475	4	8	5
16	R:R:V201	6.0675	4	8	6
17	R:R:L202	5.8925	4	7	4
18	R:R:Y206	3.99	5	3	4
19	R:R:L210	5.9275	4	7	4
20	R:R:Y211	3.826	5	0	7
21	R:R:W222	12.0875	4	14	8
22	R:R:M223	3.5875	4	3	6
23	R:R:C230	2.5525	4	0	7
24	R:R:F231	4.39	4	15	4
25	R:R:F236	6.7275	4	5	5
26	R:R:T240	5.005	4	5	9
27	R:R:Y250	3.90429	7	2	9
28	R:R:P254	4.4075	4	2	8
29	R:R:N263	4.0075	4	15	5
30	R:R:Y265	5.965	4	0	7
31	R:R:R272	8.135	4	3	8
32	R:R:V275	5.005	4	0	4
33	R:R:R277	6.058	5	3	6
34	R:R:V291	7.58	4	8	4
35	R:R:L297	4.675	4	0	6
36	R:R:L309	4.1375	4	0	6
37	R:R:Y310	4.498	5	9	9
38	R:R:W319	7.764	5	2	9
39	R:R:W320	11.13	4	10	9
40	R:R:T324	4.9725	4	10	8
41	R:R:T326	3.22	4	2	8
42	R:R:W327	6.304	5	2	9
43	R:R:F328	3.3825	4	0	7
44	R:R:W335	5.015	4	13	8
45	R:R:F347	4.28	4	2	8
46	R:R:W352	4.8925	4	2	9
47	R:R:T374	3.74333	6	3	8
48	R:R:Y378	4.275	4	9	6
49	R:R:Y398	5.74	4	0	6
50	R:R:F405	3.5275	4	0	8
51	R:R:R417	7.6175	4	16	8
52	R:R:I437	4.53	4	2	8
53	R:R:F440	4.2025	4	10	9
54	R:R:Y444	8.5325	4	10	8
55	R:R:I452	1.995	4	0	6
56	R:R:Y455	8.4625	4	11	4
57	R:R:N461	4.7575	4	4	5
58	R:R:L464	4.605	4	4	1
59	R:R:F465	9.76143	7	4	8
60	R:R:R466	6.055	4	4	4
61	R:R:V487	3.865	4	0	8
62	R:R:W494	7.6525	4	0	9
63	R:R:I495	4.755	4	5	7
64	R:R:W504	6.38667	6	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F469	L:L:Y478	14.4902	11.35	Yes	Yes	0	0	0
2	L:L:L462	L:L:Y478	24.4358	3.52	No	Yes	0	0	0
3	L:L:L462	L:L:V458	30.8388	2.98	No	No	0	0	0
4	L:L:I449	L:L:Y502	14.2397	2.42	No	Yes	0	0	0
5	L:L:W444	L:L:Y502	20.5186	2.89	Yes	Yes	0	0	0
6	L:L:W444	R:R:K334	53.8885	3.48	Yes	No	0	0	8
7	L:L:V492	R:R:K334	52.5168	1.52	No	No	0	0	8
8	L:L:H490	L:L:V492	51.1522	5.54	Yes	No	0	0	0
9	L:L:H490	L:L:Y503	47.4903	7.62	Yes	Yes	1	0	0
10	L:L:G455	L:L:Y503	31.9171	2.9	No	Yes	0	0	0
11	L:L:G455	L:L:V458	31.1608	3.68	No	No	0	0	0
12	L:L:L445	L:L:W444	69.2757	5.69	No	Yes	0	0	0
13	L:L:L445	R:R:L430	69.8292	2.77	No	No	0	0	8
14	R:R:L430	R:R:M434	71.7615	7.07	No	No	0	8	8
15	R:R:L413	R:R:M434	75.0728	2.83	No	No	0	8	8
16	R:R:A331	R:R:L413	76.089	3.15	No	No	0	8	8
17	R:R:A331	R:R:G332	76.59	1.95	No	No	0	8	7
18	R:R:F328	R:R:G332	77.5777	3.01	Yes	No	0	7	7
19	R:R:F328	R:R:F405	81.7859	5.36	Yes	Yes	0	7	8
20	R:R:F405	R:R:T324	83.5321	2.59	Yes	Yes	0	8	8
21	R:R:T324	R:R:W320	79.677	7.28	Yes	Yes	10	8	9
22	R:R:W320	R:R:Y444	78.2242	27.01	Yes	Yes	10	9	8
23	R:R:V487	R:R:Y444	100	2.52	Yes	Yes	0	8	8
24	R:R:V487	R:R:Y262	95.725	7.57	Yes	No	0	8	8
25	R:R:Y262	R:R:Y265	94.6944	2.98	No	Yes	0	8	7
26	R:R:Y265	R:R:Y269	63.1328	9.93	Yes	No	0	7	6
27	R:R:M223	R:R:Y269	61.9018	4.79	Yes	No	0	6	6
28	R:R:M223	R:R:R272	56.7871	3.72	Yes	Yes	3	6	8
29	R:R:R272	R:R:R277	51.4695	9.6	Yes	Yes	3	8	6
30	R:R:K216	R:R:R277	47.7265	7.43	No	Yes	3	6	6
31	R:R:K216	R:R:Y211	47.6907	3.58	No	Yes	0	6	7
32	R:R:L210	R:R:Y211	22.2697	2.34	Yes	Yes	0	4	7
33	R:R:L210	R:R:Q190	15.8452	10.65	Yes	Yes	7	4	3
34	R:R:L309	R:R:Y265	57.3954	5.86	Yes	Yes	0	6	7
35	R:R:L309	R:R:Y378	48.5162	4.69	Yes	Yes	0	6	6
36	R:R:Y310	R:R:Y378	41.1064	3.97	Yes	Yes	9	9	6
37	R:R:I362	R:R:Y310	29.7557	7.25	No	Yes	9	6	9
38	R:R:F306	R:R:I362	29.1593	6.28	No	No	0	9	6
39	R:R:F306	R:R:V368	22.9973	9.18	No	No	0	9	8
40	R:R:C377	R:R:V368	19.6861	1.71	No	No	0	9	8
41	R:R:A370	R:R:C377	16.0981	1.81	No	No	0	8	9
42	R:R:A370	R:R:L292	13.357	4.73	No	No	0	8	5
43	R:R:L292	R:R:Q294	12.4338	2.66	No	No	0	5	6
44	R:R:Q294	R:R:V201	11.5058	5.73	No	Yes	0	6	6
45	R:R:N473	R:R:Y211	24.7006	2.33	No	Yes	0	5	7
46	R:R:G488	R:R:V487	63.066	1.84	No	Yes	0	9	8
47	R:R:C230	R:R:G488	23.4434	1.96	Yes	No	0	7	9
48	R:R:C230	R:R:I489	18.7485	1.64	Yes	No	0	7	8
49	R:R:I489	R:R:W226	17.8563	2.35	No	No	0	8	5
50	R:R:W222	R:R:W226	13.19	21.56	Yes	No	14	8	5
51	R:R:G488	R:R:S491	44.2173	3.71	No	No	0	9	8
52	R:R:S491	R:R:T234	16.153	3.2	No	No	0	8	8
53	R:R:S259	R:R:T234	13.5383	4.8	No	No	0	8	8
54	R:R:G492	R:R:S491	27.4369	1.86	No	No	0	7	8
55	R:R:G492	R:R:W496	26.6306	5.63	No	No	0	7	6
56	R:R:I495	R:R:W496	25.0417	5.87	Yes	No	0	7	6
57	R:R:F236	R:R:I495	15.8309	2.51	Yes	Yes	5	5	7
58	R:R:S259	R:R:T237	10.418	7.99	No	No	0	8	8
59	R:R:T240	R:R:W504	15.9884	6.06	Yes	Yes	5	9	9
60	R:R:I406	R:R:T324	15.9478	4.56	No	Yes	0	8	8
61	R:R:I406	R:R:I437	15.1391	2.94	No	Yes	0	8	8
62	R:R:I437	R:R:W327	11.0501	10.57	Yes	Yes	2	8	9
63	R:R:L323	R:R:P254	15.5852	6.57	No	Yes	0	9	8
64	R:R:F440	R:R:W494	16.5728	5.01	Yes	Yes	0	9	9
65	R:R:I255	R:R:W494	14.1395	17.62	No	Yes	0	8	9
66	R:R:S317	R:R:Y444	12.8394	2.54	No	Yes	0	6	8
67	R:R:S317	R:R:Y398	11.94	6.36	No	Yes	0	6	6
68	R:R:M314	R:R:Y310	10.573	3.59	No	Yes	0	8	9
69	R:R:F465	R:R:N473	18.3358	20.54	Yes	No	4	8	5
70	R:R:F465	R:R:R466	12.2167	5.34	Yes	Yes	4	8	4
71	R:R:R466	R:R:W462	10.4681	11	Yes	No	0	4	7
72	R:R:W504	R:R:Y508	13.2497	7.72	Yes	No	0	9	3
73	R:R:F440	R:R:Y444	17.4364	2.06	Yes	Yes	10	9	8
74	R:R:I255	R:R:L323	13.3308	4.28	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R442	R:R:H337	3.39	6	Yes	No	0	6	0	1
L:L:R442	R:R:E338	5.82	6	Yes	No	0	9	0	1
L:L:W444	R:R:K334	3.48	0	Yes	No	0	8	0	1
L:L:L445	R:R:L430	2.77	0	No	No	0	8	0	1
L:L:K446	R:R:K429	4.31	0	No	No	0	8	0	1
L:L:Q500	R:R:W335	2.19	13	No	Yes	0	8	0	1
L:L:Q500	R:R:A339	3.03	13	No	No	0	8	0	1
L:L:Y502	R:R:G336	5.79	6	Yes	No	0	7	0	1
L:L:Y502	R:R:H337	2.18	6	Yes	No	0	6	0	1
L:L:Y502	R:R:E338	3.37	6	Yes	No	0	9	0	1
R:R:L329	R:R:W335	7.97	0	No	Yes	8	8	2	1
R:R:L333	R:R:W335	3.42	0	No	Yes	6	8	2	1
R:R:I416	R:R:K334	5.82	0	No	No	8	8	2	1
R:R:A339	R:R:W335	6.48	13	No	Yes	8	8	1	1
R:R:E338	R:R:H337	19.69	6	No	No	9	6	1	1
R:R:L430	R:R:R417	4.86	0	No	Yes	8	8	1	2
R:R:D428	R:R:K429	4.15	0	No	No	4	8	2	1
R:R:L430	R:R:M434	7.07	0	No	No	8	8	1	2
L:L:V492	R:R:K334	1.52	0	No	No	0	8	0	1
L:L:T448	R:R:K429	1.5	0	No	No	0	8	0	1
L:L:I447	R:R:L420	1.43	0	No	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
62.50	Single	8WM9	DVL-2	8WM9-FZD₄-DVL-2
6.25	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
6.25	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
4.17	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.57	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
3.23	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	8WMA
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD4
Species	Homo Sapiens
Ligand	DVL-2
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.47
Date	2024-09-11
D.O.I.	doi.org/10.1038/s41467-024-52174-z

Net Summary
I_min	1.84
Number of Linked Nodes	382
Number of Links	434
Number of Hubs	64
Number of Links mediated by Hubs	234
Number of Communities	16
Number of Nodes involved in Communities	99
Number of Links involved in Communities	134

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	84182
Length Of Smallest Path	3
Average Path Length	18.7861
Length of Longest Path	46
Minimum Path Strength	1.195
Average Path Strength	5.26157
Maximum Path Strength	20.67
Minimum Path Correlation	0.7
Average Path Correlation	0.954148
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	54.921
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.7174
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • amide binding • amyloid-beta binding • binding • peptide binding • protein-containing complex binding • ubiquitin protein ligase binding • protein binding • ubiquitin-like protein ligase binding • enzyme binding • Wnt-protein binding • G protein-coupled receptor activity • PDZ domain binding • protein domain specific binding • protein heterodimerization activity • protein dimerization activity • cytokine receptor activity • immune receptor activity • cytokine binding • identical protein binding • protein homodimerization activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • cell population proliferation • cell adhesion
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • cell population proliferation • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • positive regulation of DNA-binding transcription factor activity • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • positive regulation of molecular function • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of molecular function • regulation of gene expression • biosynthetic process • regulation of DNA-binding transcription factor activity • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • response to chemical • cellular response to lipid • multicellular organismal process • system process • sensory perception • nervous system process • sensory perception of sound • sensory perception of mechanical stimulus • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • regulation of cellular component organization • positive regulation of cellular component organization • regulation of developmental process • cellular developmental process • regulation of neuron projection arborization • cell projection organization • plasma membrane bounded cell projection morphogenesis • positive regulation of biological process • cell development • neuron projection development • cell morphogenesis • regulation of cell morphogenesis • cellular component organization • positive regulation of developmental process • neurogenesis • multicellular organism development • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • anatomical structure development • positive regulation of cell projection organization • cellular component organization or biogenesis • regulation of anatomical structure morphogenesis • positive regulation of cellular process • system development • developmental process • plasma membrane bounded cell projection organization • regulation of cell projection organization • positive regulation of neuron projection arborization • nervous system development • generation of neurons • anatomical structure morphogenesis • neuron projection arborization • neuron development • sensory organ development • blood vessel morphogenesis • tube development • retina vasculature development in camera-type eye • eye development • animal organ development • retina development in camera-type eye • visual system development • retina vasculature morphogenesis in camera-type eye • vasculature development • circulatory system development • tube morphogenesis • camera-type eye development • retinal blood vessel morphogenesis • sensory system development • blood vessel development • establishment of blood-brain barrier • central nervous system development • angiogenesis • anatomical structure formation involved in morphogenesis • head development • cerebellum vasculature development • brain development • cerebellum development • metencephalon development • cerebellum vasculature morphogenesis • hindbrain development • non-canonical Wnt signaling pathway • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • Norrin signaling pathway • cellular process involved in reproduction in multicellular organism • localization • development of primary sexual characteristics • reproductive structure development • regulation of biological quality • gonad development • luteinization • regulation of hormone levels • lipid transport • establishment of localization • endocrine hormone secretion • lipid export from cell • ovulation cycle process • transport • reproductive process • steroid hormone secretion • sex differentiation • development of primary female sexual characteristics • hormone secretion • developmental process involved in reproduction • progesterone secretion • ovulation cycle • secretion by cell • signal release • rhythmic process • reproductive system development • secretion • female gonad development • multicellular organismal reproductive process • lipid localization • export from cell • cell-cell signaling • female sex differentiation • endocrine process • macromolecule localization • hormone transport • cellular response to growth factor stimulus • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • regulation of vascular endothelial growth factor receptor signaling pathway • cellular response to endogenous stimulus • enzyme-linked receptor protein signaling pathway • regulation of signaling • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • vascular endothelial growth factor receptor signaling pathway • regulation of response to stimulus • regulation of cell communication • response to growth factor • vasculogenesis • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • extracellular matrix-cell signaling • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of biological process • negative regulation of cell adhesion • negative regulation of cellular process • negative regulation of cell-substrate adhesion • Wnt signaling pathway, calcium modulating pathway • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of nucleobase-containing compound metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • behavior • locomotory behavior • locomotion involved in locomotory behavior • positive regulation of nervous system development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of dendrite morphogenesis • positive regulation of cell development • positive regulation of cell morphogenesis • regulation of dendrite development • positive regulation of multicellular organismal process • regulation of neuron projection development • regulation of nervous system development • positive regulation of cell differentiation • dendrite development • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of dendrite morphogenesis • dendrite morphogenesis • cell morphogenesis involved in neuron differentiation • regulation of plasma membrane bounded cell projection organization • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle
Gene Ontology	Cellular Component	• cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • glutamatergic synapse • cell surface • cell periphery • plasma membrane • small GTPase binding • protein binding • binding • enzyme binding • GTPase binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • protein-macromolecule adaptor activity • molecular adaptor activity • identical protein binding • protein domain specific binding • kinase binding • protein kinase binding • developmental process • multicellular organism development • multicellular organismal process • segmentation • anatomical structure development • pattern specification process • regionalization • segment specification • heart development • animal organ development • circulatory system development • system development • protein localization • localization • cellular localization • cellular macromolecule localization • macromolecule localization • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • signal transduction • Wnt signaling pathway • positive regulation of DNA-binding transcription factor activity • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • positive regulation of molecular function • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of molecular function • regulation of gene expression • biosynthetic process • regulation of DNA-binding transcription factor activity • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • embryonic epithelial tube formation • chordate embryonic development • tube formation • embryo development • epithelial tube formation • tube morphogenesis • primary neural tube formation • embryo development ending in birth or egg hatching • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • epithelium development • neural tube development • tube development • embryonic morphogenesis • morphogenesis of an epithelium • nervous system development • tissue development • anatomical structure morphogenesis • tissue morphogenesis • neural tube closure • neural tube formation • anatomical structure formation involved in morphogenesis • tube closure • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • Wnt signaling pathway, planar cell polarity pathway • non-canonical Wnt signaling pathway • neural plate development • convergent extension involved in gastrulation • convergent extension involved in organogenesis • morphogenesis of an epithelial sheet • gastrulation • convergent extension involved in neural plate elongation • neural plate elongation • convergent extension • neural plate morphogenesis • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of MAP kinase activity • positive regulation of protein serine/threonine kinase activity • positive regulation of metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • positive regulation of JUN kinase activity • positive regulation of kinase activity • regulation of kinase activity • regulation of protein serine/threonine kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of protein modification process • protein metabolic process • positive regulation of protein kinase activity • positive regulation of transferase activity • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of JUN kinase activity • regulation of phosphorylation • regulation of cellular component organization • positive regulation of cellular component organization • regulation of developmental process • cellular developmental process • regulation of neuron projection arborization • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • regulation of cell morphogenesis • cellular component organization • positive regulation of developmental process • neurogenesis • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • positive regulation of cell projection organization • cellular component organization or biogenesis • regulation of anatomical structure morphogenesis • plasma membrane bounded cell projection organization • regulation of cell projection organization • positive regulation of neuron projection arborization • generation of neurons • neuron projection arborization • neuron development • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • animal organ morphogenesis • embryonic organ development • determination of left/right symmetry • specification of symmetry • embryonic organ morphogenesis • determination of heart left/right asymmetry • left/right pattern formation • regulation of cytoskeleton organization • regulation of actin filament-based process • actin cytoskeleton organization • regulation of organelle organization • organelle organization • regulation of actin cytoskeleton organization • actin filament-based process • cytoskeleton organization • ear morphogenesis • ear development • sensory organ development • sensory organ morphogenesis • inner ear development • cochlea development • inner ear morphogenesis • cochlea morphogenesis • cell population proliferation • regulation of cell population proliferation • outflow tract morphogenesis • apical part of cell • cytosol • inclusion body • aggresome • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • lateral plasma membrane • nuclear body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Winged helix DNA-binding domain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Winged helix DNA-binding domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9ULV1
Sequence	>8WMA_Chain_R S D Q Y I W V K R S L N C V L K C G Y D A G L Y S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D S S R F S Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G R E R I S C E A A E P V L I Q E G L K N T G C A I I F L L L Y F F G M A S S I W W V I L T L T W F L A A G L K W G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R L V D A D E L T G L C Y V G N Q N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N L Q K D G T K T D K L E R L M V K I G V F S V L Y T V P A T I V I A C Y F Y E I S N W A L F R Y S A D D S N M A V E M L K I F M S L L V G I T S G M W I W S A K T L H T W Q K F Y N R L V N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WM9	F	Protein	Frizzled	FZD₄	Homo sapiens	DVL-2	-	-	3.53	2024-09-11	doi.org/10.1038/s41467-024-52174-z
	6BD4	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	-	2.4	2018-08-22	10.1038/s41586-018-0447-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WMA.zip

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