psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K37	5.3	Yes	Yes	1	0	4
2	L:L:?1	R:R:Y119	28.93	Yes	No	0	0	5
3	L:L:?1	R:R:Y123	13.21	Yes	No	0	0	7
4	L:L:?1	R:R:S169	8.86	Yes	No	0	0	5
5	L:L:?1	R:R:L198	7.43	Yes	No	0	0	4
6	L:L:?1	R:R:H284	8.97	Yes	Yes	1	0	4
7	L:L:?1	R:R:L287	5.2	Yes	No	0	0	4
8	R:R:H284	R:R:I33	9.28	Yes	No	0	4	1
9	R:R:E34	R:R:N35	5.26	No	No	3	4	5
10	R:R:E34	R:R:R38	18.61	No	No	3	4	4
11	R:R:N35	R:R:R38	4.82	No	No	3	5	4
12	R:R:F36	R:R:F40	11.79	No	No	0	6	5
13	R:R:F36	R:R:K285	14.89	No	No	0	6	1
14	R:R:F41	R:R:K37	9.93	Yes	Yes	1	5	4
15	R:R:K37	R:R:Y98	5.97	Yes	Yes	1	4	5
16	R:R:H284	R:R:K37	7.86	Yes	Yes	1	4	4
17	R:R:F40	R:R:V44	9.18	No	No	0	5	5
18	R:R:A292	R:R:F40	4.16	No	No	0	5	5
19	R:R:F41	R:R:Y45	18.57	Yes	Yes	0	5	8
20	R:R:F41	R:R:Y98	22.69	Yes	Yes	1	5	5
21	R:R:F41	R:R:V288	6.55	Yes	No	0	5	5
22	R:R:L99	R:R:P42	6.57	No	No	0	4	5
23	R:R:V44	R:R:Y45	3.79	No	Yes	0	5	8
24	R:R:L91	R:R:Y45	11.72	No	Yes	0	7	8
25	R:R:R94	R:R:Y45	8.23	No	Yes	0	6	8
26	R:R:I47	R:R:W51	5.87	No	Yes	0	5	5
27	R:R:F49	R:R:V53	6.55	No	No	0	6	6
28	R:R:F49	R:R:I88	5.02	No	Yes	0	6	6
29	R:R:F49	R:R:P92	14.45	No	No	0	6	9
30	R:R:D84	R:R:N56	4.04	Yes	Yes	0	9	9
31	R:R:L85	R:R:N56	4.12	No	Yes	0	7	9
32	R:R:I88	R:R:N56	4.25	Yes	Yes	0	6	9
33	R:R:L316	R:R:L58	4.15	No	No	0	5	5
34	R:R:L320	R:R:L58	4.15	No	No	0	6	5
35	R:R:F63	R:R:S59	5.28	Yes	No	2	6	9
36	R:R:S59	R:R:Y306	7.63	No	Yes	2	9	6
37	R:R:F307	R:R:S59	3.96	No	No	0	7	9
38	R:R:F312	R:R:V62	7.87	Yes	No	0	8	7
39	R:R:R315	R:R:V62	3.92	Yes	No	0	4	7
40	R:R:L316	R:R:V62	4.47	No	No	0	5	7
41	R:R:F63	R:R:M77	7.46	Yes	No	2	6	8
42	R:R:F63	R:R:Y306	13.41	Yes	Yes	2	6	6
43	R:R:F312	R:R:F63	7.5	Yes	Yes	2	8	6
44	R:R:Q65	R:R:Y67	9.02	Yes	No	4	5	5
45	R:R:Q65	R:R:R315	4.67	Yes	Yes	0	5	4
46	R:R:Q65	R:R:S318	7.22	Yes	No	4	5	4
47	R:R:A319	R:R:Q65	4.55	No	Yes	0	4	5
48	R:R:K68	R:R:Y67	5.97	Yes	No	0	6	5
49	R:R:S318	R:R:Y67	13.99	No	No	4	4	5
50	R:R:K68	R:R:N311	6.99	Yes	No	0	6	6
51	R:R:K68	R:R:R315	7.43	Yes	Yes	0	6	4
52	R:R:N74	R:R:T71	7.31	No	No	0	7	7
53	R:R:F76	R:R:S72	5.28	Yes	No	0	7	6
54	R:R:N74	R:R:V73	4.43	No	No	0	7	7
55	R:R:M77	R:R:V73	4.56	No	No	0	8	7
56	R:R:N74	R:R:R315	4.82	No	Yes	0	7	4
57	R:R:A155	R:R:V75	5.09	No	No	0	7	6
58	R:R:V75	R:R:W156	22.07	No	No	0	6	4
59	R:R:F76	R:R:V131	7.87	Yes	No	0	7	6
60	R:R:F76	R:R:L132	4.87	Yes	No	0	7	9
61	R:R:F76	R:R:V135	3.93	Yes	No	0	7	8
62	R:R:A155	R:R:F76	5.55	No	Yes	0	7	7
63	R:R:M77	R:R:Y306	9.58	No	Yes	2	8	6
64	R:R:I82	R:R:L78	4.28	No	No	0	5	5
65	R:R:C159	R:R:N79	12.6	No	No	0	7	9
66	R:R:N79	R:R:W163	4.52	No	Yes	0	9	9
67	R:R:D84	R:R:L80	8.14	Yes	No	0	9	9
68	R:R:L129	R:R:L80	5.54	No	No	0	8	9
69	R:R:L80	R:R:Y306	7.03	No	Yes	0	9	6
70	R:R:D84	R:R:S83	4.42	Yes	No	0	9	8
71	R:R:F128	R:R:S83	5.28	Yes	No	0	8	8
72	R:R:D84	R:R:S125	5.89	Yes	No	0	9	9
73	R:R:D84	R:R:N301	5.39	Yes	No	0	9	9
74	R:R:L86	R:R:N121	5.49	No	No	0	6	8
75	R:R:F87	R:R:L118	8.53	Yes	No	0	6	6
76	R:R:F87	R:R:N121	4.83	Yes	No	0	6	8
77	R:R:M114	R:R:T90	6.02	No	No	0	5	7
78	R:R:S117	R:R:T90	6.4	No	No	0	5	7
79	R:R:F106	R:R:F93	6.43	Yes	No	0	5	6
80	R:R:F93	R:R:M114	13.68	No	No	0	6	5
81	R:R:L118	R:R:R94	6.07	No	No	0	6	6
82	R:R:L188	R:R:R94	10.93	Yes	No	0	3	6
83	R:R:D96	R:R:R100	5.96	No	No	0	3	4
84	R:R:Y97	R:R:Y98	12.91	Yes	Yes	1	5	5
85	R:R:S102	R:R:Y97	7.63	No	Yes	1	5	5
86	R:R:W104	R:R:Y97	8.68	Yes	Yes	1	8	5
87	R:R:L188	R:R:Y97	5.86	Yes	Yes	1	3	5
88	R:R:E189	R:R:Y97	6.73	No	Yes	1	5	5
89	R:R:L188	R:R:Y98	4.69	Yes	Yes	1	3	5
90	R:R:I105	R:R:R100	3.76	No	No	0	4	4
91	R:R:E189	R:R:S102	5.75	No	No	1	5	5
92	R:R:N103	R:R:V184	5.91	No	No	0	4	1
93	R:R:F106	R:R:W104	11.02	Yes	Yes	0	5	8
94	R:R:A110	R:R:W104	3.89	No	Yes	0	5	8
95	R:R:C111	R:R:W104	6.53	No	Yes	1	9	8
96	R:R:T185	R:R:W104	4.85	No	Yes	0	4	8
97	R:R:C187	R:R:W104	16.98	No	Yes	1	9	8
98	R:R:L188	R:R:W104	4.56	Yes	Yes	1	3	8
99	R:R:F106	R:R:I105	7.54	Yes	No	0	5	4
100	R:R:D108	R:R:R112	17.87	No	No	0	4	7
101	R:R:D108	R:R:S178	8.83	No	No	0	4	5
102	R:R:I113	R:R:L109	4.28	No	No	0	5	3
103	R:R:C111	R:R:C187	7.28	No	No	1	9	9
104	R:R:V120	R:R:Y116	8.83	No	Yes	0	5	5
105	R:R:M167	R:R:Y116	5.99	No	Yes	0	3	5
106	R:R:S170	R:R:Y116	7.63	No	Yes	0	7	5
107	R:R:L174	R:R:Y116	7.03	No	Yes	0	5	5
108	R:R:N121	R:R:S117	5.96	No	No	0	8	5
109	R:R:L118	R:R:Y119	9.38	No	No	0	6	5
110	R:R:Y119	R:R:Y263	3.97	No	Yes	0	5	7
111	R:R:A205	R:R:Y123	5.34	No	No	0	5	7
112	R:R:F128	R:R:S124	10.57	Yes	No	5	8	7
113	R:R:S124	R:R:W163	13.59	No	Yes	5	7	9
114	R:R:F260	R:R:I126	12.56	Yes	No	0	9	7
115	R:R:I166	R:R:Y127	4.84	No	No	0	7	5
116	R:R:F128	R:R:I162	5.02	Yes	No	0	8	6
117	R:R:F128	R:R:W163	11.02	Yes	Yes	5	8	9
118	R:R:L129	R:R:N301	12.36	No	No	0	8	9
119	R:R:L129	R:R:Y305	9.38	No	Yes	0	8	9
120	R:R:T130	R:R:T216	4.71	No	No	0	7	6
121	R:R:L132	R:R:Y305	4.69	No	Yes	0	9	9
122	R:R:L217	R:R:S133	4.5	No	No	0	7	9
123	R:R:S133	R:R:Y221	5.09	No	Yes	0	9	8
124	R:R:R136	R:R:Y221	13.38	No	Yes	6	9	8
125	R:R:R136	R:R:Y305	11.32	No	Yes	6	9	9
126	R:R:F137	R:R:L138	6.09	Yes	No	0	8	5
127	R:R:F137	R:R:V141	13.11	Yes	No	0	8	7
128	R:R:C220	R:R:F137	8.38	No	Yes	0	6	8
129	R:R:F137	R:R:L223	7.31	Yes	No	0	8	4
130	R:R:F137	R:R:I224	3.77	Yes	No	0	8	8
131	R:R:H148	R:R:L138	7.71	No	No	0	3	5
132	R:R:H142	R:R:V141	11.07	No	No	0	6	7
133	R:R:H142	R:R:L146	7.71	No	No	0	6	6
134	R:R:H148	R:R:L146	3.86	No	No	0	3	6
135	R:R:S151	R:R:S154	6.52	No	No	0	6	4
136	R:R:I157	R:R:R153	6.26	No	No	0	3	4
137	R:R:I162	R:R:L158	5.71	No	No	0	6	5
138	R:R:I171	R:R:L174	4.28	No	No	0	4	5
139	R:R:M172	R:R:M201	5.78	No	Yes	0	8	5
140	R:R:D175	R:R:K197	9.68	No	No	0	5	3
141	R:R:E179	R:R:N191	19.72	No	No	7	4	5
142	R:R:E179	R:R:Y193	6.73	No	No	0	4	3
143	R:R:E179	R:R:K194	8.1	No	No	7	4	3
144	R:R:Q180	R:R:T185	5.67	No	No	0	3	4
145	R:R:N181	R:R:V184	4.43	No	No	0	2	1
146	R:R:E189	R:R:S186	4.31	No	No	0	5	3
147	R:R:N191	R:R:S186	4.47	No	No	0	5	3
148	R:R:C187	R:R:L188	7.94	No	Yes	1	9	3
149	R:R:I195	R:R:L190	4.28	Yes	No	8	2	4
150	R:R:L190	R:R:W274	10.25	No	No	8	4	3
151	R:R:K194	R:R:N191	4.2	No	No	7	3	5
152	R:R:I195	R:R:Q199	4.12	Yes	No	0	2	3
153	R:R:I195	R:R:W274	7.05	Yes	No	8	2	3
154	R:R:K197	R:R:M201	4.32	No	Yes	0	3	5
155	R:R:L198	R:R:L271	4.15	No	No	0	4	5
156	R:R:N202	R:R:R267	14.46	No	No	0	5	5
157	R:R:N202	R:R:T268	7.31	No	No	0	5	6
158	R:R:L271	R:R:N202	4.12	No	No	0	5	5
159	R:R:T268	R:R:Y203	4.99	No	No	0	6	4
160	R:R:T272	R:R:Y203	6.24	No	No	0	4	4
161	R:R:L206	R:R:T268	5.9	No	No	0	5	6
162	R:R:G209	R:R:P213	4.06	No	Yes	0	5	9
163	R:R:C210	R:R:L261	4.76	No	No	0	8	5
164	R:R:C210	R:R:H264	17.69	No	No	0	8	8
165	R:R:F214	R:R:S218	7.93	No	No	0	6	4
166	R:R:F214	R:R:F257	6.43	No	No	0	6	5
167	R:R:F214	R:R:L261	17.05	No	No	0	6	5
168	R:R:F256	R:R:L217	7.31	No	No	0	9	7
169	R:R:L253	R:R:Y221	7.03	No	Yes	0	7	8
170	R:R:Y221	R:R:Y305	4.96	Yes	Yes	6	8	9
171	R:R:L223	R:R:R226	4.86	No	No	0	4	4
172	R:R:I225	R:R:I249	7.36	No	No	0	5	7
173	R:R:H242	R:R:L228	3.86	No	No	0	7	8
174	R:R:R239	R:R:S241	3.95	No	No	0	3	5
175	R:R:H242	R:R:R239	24.83	No	No	0	7	3
176	R:R:I250	R:R:L246	4.28	No	No	0	4	5
177	R:R:I251	R:R:L304	4.28	No	No	0	5	7
178	R:R:L304	R:R:T252	5.9	No	No	0	7	7
179	R:R:F300	R:R:I255	3.77	No	No	0	7	6
180	R:R:F256	R:R:F260	10.72	No	Yes	0	9	9
181	R:R:F260	R:R:H264	4.53	Yes	No	0	9	8
182	R:R:F260	R:R:N297	10.87	Yes	No	0	9	9
183	R:R:H264	R:R:Y263	7.62	No	Yes	0	8	7
184	R:R:R267	R:R:Y263	8.23	No	Yes	0	5	7
185	R:R:T290	R:R:Y263	8.74	No	Yes	0	6	7
186	R:R:L291	R:R:Y263	8.21	No	Yes	0	5	7
187	R:R:A286	R:R:L266	4.73	No	No	0	5	5
188	R:R:L266	R:R:T290	7.37	No	No	0	5	6
189	R:R:H270	R:R:W274	5.29	No	No	0	4	3
190	R:R:H270	R:R:L287	5.14	No	No	0	4	4
191	R:R:T272	R:R:T273	6.28	No	No	0	4	3
192	R:R:C279	R:R:H284	5.9	No	Yes	0	1	4
193	R:R:A296	R:R:F300	5.55	No	No	0	5	7
194	R:R:N297	R:R:N301	10.9	No	No	0	9	9
195	R:R:P302	R:R:Y306	4.17	No	Yes	0	9	6
196	R:R:F312	R:R:Y306	7.22	Yes	Yes	2	8	6
197	R:R:F307	R:R:F312	9.65	No	Yes	0	7	8
198	R:R:F215	R:R:L211	3.65	No	No	0	3	4
199	R:R:F257	R:R:L258	3.65	No	No	0	5	6
200	R:R:F307	R:R:L303	3.65	No	No	0	7	6
201	R:R:L283	R:R:R282	3.64	Yes	No	0	4	3
202	R:R:I162	R:R:Y127	3.63	No	No	0	6	5
203	R:R:I249	R:R:Y221	3.63	No	Yes	0	7	8
204	R:R:N103	R:R:R100	3.62	No	No	0	4	4
205	R:R:G52	R:R:I88	3.53	No	Yes	0	8	6
206	R:R:P213	R:R:T130	3.5	Yes	No	0	9	7
207	R:R:G323	R:R:K322	3.49	No	No	0	1	5
208	R:R:I126	R:R:P213	3.39	No	Yes	0	7	9
209	R:R:D108	R:R:G177	3.35	No	No	0	4	5
210	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
211	R:R:C299	R:R:I48	3.27	No	No	0	6	7
212	R:R:A296	R:R:I48	3.25	No	No	0	5	7
213	R:R:A81	R:R:I60	3.25	No	No	0	8	7
214	R:R:A298	R:R:I88	3.25	No	Yes	0	8	6
215	R:R:V141	R:R:V227	3.21	No	No	0	7	5
216	R:R:V207	R:R:V208	3.21	No	No	0	4	4
217	R:R:S178	R:R:T185	3.2	No	No	0	5	4
218	R:R:T150	R:R:V149	3.17	No	No	0	6	4
219	R:R:P66	R:R:Q65	3.16	No	Yes	0	5	5
220	R:R:A245	R:R:L228	3.15	No	No	0	7	8
221	R:R:I48	R:R:V44	3.07	No	No	0	7	5
222	R:R:I166	R:R:V120	3.07	No	No	0	7	5
223	R:R:K194	R:R:S176	3.06	No	No	0	3	4
224	R:R:F50	R:R:W51	3.01	No	Yes	0	5	5
225	R:R:M201	R:R:T200	3.01	Yes	No	0	5	3
226	R:R:L85	R:R:S89	3	No	No	0	7	5
227	R:R:L173	R:R:S115	3	No	No	0	5	6
228	R:R:L138	R:R:V134	2.98	No	No	0	5	5
229	L:L:?1	R:R:L173	2.97	Yes	No	0	0	5
230	R:R:I157	R:R:I161	2.94	No	No	0	3	3
231	R:R:N35	R:R:T32	2.92	No	No	0	5	5
232	R:R:I60	R:R:L64	2.85	No	No	0	7	3
233	R:R:I60	R:R:L85	2.85	No	No	0	7	7
234	R:R:I82	R:R:L86	2.85	No	No	0	5	6
235	R:R:I161	R:R:L165	2.85	No	No	0	3	4
236	R:R:I219	R:R:L223	2.85	No	No	0	3	4
237	R:R:I224	R:R:L228	2.85	No	No	0	8	8
238	R:R:I225	R:R:L229	2.85	No	No	0	5	4
239	R:R:I225	R:R:L246	2.85	No	No	0	5	5
240	R:R:I255	R:R:L304	2.85	No	No	0	6	7
241	R:R:K280	R:R:L283	2.82	No	Yes	0	3	4
242	R:R:G160	R:R:W163	2.81	No	Yes	0	3	9
243	R:R:C259	R:R:F300	2.79	No	No	0	8	7
244	R:R:D314	R:R:K68	2.77	Yes	Yes	0	5	6
245	R:R:A295	R:R:F87	2.77	No	Yes	0	7	6
246	R:R:L206	R:R:L211	2.77	No	No	0	5	4
247	R:R:A294	R:R:F260	2.77	No	Yes	0	8	9
248	R:R:E232	R:R:K230	2.7	No	No	0	3	4
249	R:R:A95	R:R:Y45	2.67	No	Yes	0	6	8
250	R:R:A319	R:R:Y61	2.67	No	No	0	4	4
251	R:R:R239	R:R:V231	2.62	No	No	0	3	5
252	R:R:C299	R:R:W51	2.61	No	Yes	0	6	5
253	R:R:D314	R:R:E310	2.6	Yes	No	0	5	5
254	R:R:H270	R:R:L283	2.57	No	Yes	0	4	4
255	R:R:V208	R:R:Y127	2.52	No	No	0	4	5
256	R:R:F87	R:R:M122	2.49	Yes	No	0	6	7
257	R:R:I224	R:R:Y221	2.42	No	Yes	0	8	8
258	R:R:K322	R:R:Y61	2.39	No	No	0	5	4
259	R:R:L54	R:R:W51	2.28	No	Yes	0	4	5
260	R:R:A308	R:R:G309	1.95	No	No	0	6	8
261	R:R:G101	R:R:S102	1.86	No	No	0	4	5
262	R:R:P262	R:R:T290	1.75	No	No	0	9	6
263	R:R:G55	R:R:N56	1.7	No	Yes	0	7	9
264	R:R:A139	R:R:V149	1.7	No	No	0	8	4
265	R:R:S151	R:R:S72	1.63	No	No	0	6	6
266	R:R:S183	R:R:V184	1.62	No	No	0	5	1
267	R:R:V135	R:R:V149	1.6	No	No	0	8	4
268	R:R:I152	R:R:S70	1.55	No	No	0	3	6
269	R:R:I204	R:R:V208	1.54	No	No	0	3	4
270	R:R:I289	R:R:V288	1.54	No	No	0	5	5
271	R:R:H142	R:R:P143	1.53	No	No	0	6	8
272	L:L:?1	R:R:M201	1.52	Yes	Yes	0	0	5
273	R:R:I249	R:R:T248	1.52	No	No	0	7	7
274	R:R:F106	R:R:G107	1.51	Yes	No	0	5	7
275	R:R:G101	R:R:R38	1.5	No	No	0	4	4
276	R:R:K244	R:R:T247	1.5	No	No	0	7	6
277	R:R:L283	R:R:V269	1.49	Yes	No	0	4	5
278	R:R:I250	R:R:I254	1.47	No	No	0	4	4
279	R:R:I251	R:R:I254	1.47	No	No	0	5	4
280	R:R:I254	R:R:I255	1.47	No	No	0	4	6
281	R:R:L266	R:R:T265	1.47	No	No	0	5	5
282	R:R:F41	R:R:P42	1.44	Yes	No	0	5	5
283	R:R:F144	R:R:P143	1.44	No	No	0	5	8
284	R:R:I164	R:R:L165	1.43	No	No	0	3	4
285	R:R:I195	R:R:L192	1.43	Yes	No	0	2	4
286	R:R:D314	R:R:K313	1.38	Yes	No	0	5	8
287	R:R:D314	R:R:K317	1.38	Yes	No	0	5	4
288	R:R:I152	R:R:R153	1.25	No	No	0	3	4
289	R:R:M140	R:R:R136	1.24	No	No	0	8	9
290	R:R:L146	R:R:R145	1.21	No	No	0	6	5
291	R:R:I164	R:R:W163	1.17	No	Yes	0	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.15444	9	1	0
2	R:R:K37	7.265	4	1	4
3	R:R:F41	11.836	5	1	5
4	R:R:Y45	8.996	5	0	8
5	R:R:W51	3.4425	4	0	5
6	R:R:N56	3.5275	4	0	9
7	R:R:F63	8.4125	4	2	6
8	R:R:Q65	5.724	5	4	5
9	R:R:K68	5.79	4	0	6
10	R:R:F76	5.5	5	0	7
11	R:R:D84	5.576	5	0	9
12	R:R:F87	4.655	4	0	6
13	R:R:I88	4.0125	4	0	6
14	R:R:Y97	8.362	5	1	5
15	R:R:Y98	11.565	4	1	5
16	R:R:W104	8.07286	7	1	8
17	R:R:F106	6.625	4	0	5
18	R:R:Y116	7.37	4	0	5
19	R:R:F128	7.9725	4	5	8
20	R:R:F137	7.732	5	0	8
21	R:R:W163	6.622	5	5	9
22	R:R:L188	6.796	5	1	3
23	R:R:I195	4.22	4	8	2
24	R:R:M201	3.6575	4	0	5
25	R:R:P213	3.5575	4	0	9
26	R:R:Y221	6.085	6	6	8
27	R:R:F260	8.29	5	0	9
28	R:R:Y263	7.354	5	0	7
29	R:R:L283	2.63	4	0	4
30	R:R:H284	8.0025	4	1	4
31	R:R:Y305	7.5875	4	6	9
32	R:R:Y306	8.17333	6	2	6
33	R:R:F312	8.06	4	2	8
34	R:R:D314	2.0325	4	0	5
35	R:R:R315	5.21	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K37	29.5896	5.3	Yes	Yes	1	0	4
2	R:R:K37	R:R:Y98	21.4886	5.97	Yes	Yes	1	4	5
3	R:R:Y97	R:R:Y98	19.4211	12.91	Yes	Yes	1	5	5
4	R:R:S102	R:R:Y97	13.4409	7.63	No	Yes	1	5	5
5	R:R:G101	R:R:S102	11.3779	1.86	No	No	0	4	5
6	R:R:V44	R:R:Y45	19.639	3.79	No	Yes	0	5	8
7	R:R:I48	R:R:V44	15.0594	3.07	No	No	0	7	5
8	L:L:?1	R:R:Y119	40.1183	28.93	Yes	No	0	0	5
9	R:R:Y119	R:R:Y263	91.2232	3.97	No	Yes	0	5	7
10	R:R:H264	R:R:Y263	98.6617	7.62	No	Yes	0	8	7
11	R:R:F260	R:R:H264	100	4.53	Yes	No	0	9	8
12	R:R:F260	R:R:N297	81.5082	10.87	Yes	No	0	9	9
13	R:R:N297	R:R:N301	81.6015	10.9	No	No	0	9	9
14	R:R:D84	R:R:N301	60.4153	5.39	Yes	No	0	9	9
15	R:R:D84	R:R:N56	19.0699	4.04	Yes	Yes	0	9	9
16	R:R:D84	R:R:L80	39.3135	8.14	Yes	No	0	9	9
17	R:R:L80	R:R:Y306	58.3256	7.03	No	Yes	0	9	6
18	R:R:F312	R:R:Y306	41.1409	7.22	Yes	Yes	2	8	6
19	R:R:F312	R:R:V62	36.3167	7.87	Yes	No	0	8	7
20	R:R:L129	R:R:N301	43.6975	12.36	No	No	0	8	9
21	R:R:L129	R:R:L80	43.0528	5.54	No	No	0	8	9
22	R:R:R315	R:R:V62	29.4562	3.92	Yes	No	0	4	7
23	R:R:Q65	R:R:R315	15.0149	4.67	Yes	Yes	0	5	4
24	R:R:K68	R:R:R315	13.1653	7.43	Yes	Yes	0	6	4
25	R:R:L129	R:R:Y305	42.3236	9.38	No	Yes	0	8	9
26	R:R:L132	R:R:Y305	18.234	4.69	No	Yes	0	9	9
27	R:R:F76	R:R:L132	16.909	4.87	Yes	No	0	7	9
28	R:R:L118	R:R:Y119	53.5814	9.38	No	No	0	6	5
29	R:R:F87	R:R:L118	12.2582	8.53	Yes	No	0	6	6
30	R:R:D84	R:R:S83	37.9307	4.42	Yes	No	0	9	8
31	R:R:F128	R:R:S83	36.6413	5.28	Yes	No	0	8	8
32	R:R:F128	R:R:W163	16.1843	11.02	Yes	Yes	5	8	9
33	R:R:F106	R:R:W104	15.6952	11.02	Yes	Yes	0	5	8
34	R:R:L188	R:R:W104	23.1826	4.56	Yes	Yes	1	3	8
35	R:R:F106	R:R:I105	10.7332	7.54	Yes	No	0	5	4
36	R:R:F128	R:R:I162	19.0699	5.02	Yes	No	0	8	6
37	R:R:I162	R:R:Y127	16.2332	3.63	No	No	0	6	5
38	R:R:I166	R:R:Y127	10.4531	4.84	No	No	0	7	5
39	R:R:F256	R:R:F260	21.1729	10.72	No	Yes	0	9	9
40	R:R:F256	R:R:L217	20.297	7.31	No	No	0	9	7
41	R:R:L217	R:R:S133	19.8835	4.5	No	No	0	7	9
42	R:R:S133	R:R:Y221	20.0836	5.09	No	Yes	0	9	8
43	R:R:I224	R:R:Y221	31.8394	2.42	No	Yes	0	8	8
44	R:R:F137	R:R:I224	23.2004	3.77	Yes	No	0	8	8
45	R:R:I164	R:R:W163	10.4531	1.17	No	Yes	0	3	9
46	R:R:E189	R:R:Y97	15.4551	6.73	No	Yes	1	5	5
47	R:R:E189	R:R:S186	13.4987	4.31	No	No	0	5	3
48	R:R:N191	R:R:S186	11.2401	4.47	No	No	0	5	3
49	L:L:?1	R:R:L287	15.1972	5.2	Yes	No	0	0	4
50	R:R:H270	R:R:L287	13.9078	5.14	No	No	0	4	4
51	R:R:R267	R:R:Y263	10.9377	8.23	No	Yes	0	5	7
52	R:R:N202	R:R:T268	11.2	7.31	No	No	0	5	6
53	R:R:I249	R:R:Y221	17.2602	3.63	No	Yes	0	7	8
54	R:R:I225	R:R:I249	14.9349	7.36	No	No	0	5	7
55	R:R:A296	R:R:I48	10.6309	3.25	No	No	0	5	7
56	R:R:A296	R:R:F300	10.5553	5.55	No	No	0	5	7
57	R:R:F300	R:R:I255	10.7865	3.77	No	No	0	7	6
58	R:R:I254	R:R:I255	10.6398	1.47	No	No	0	4	6
59	R:R:I250	R:R:I254	12.6406	1.47	No	No	0	4	4
60	R:R:I225	R:R:L246	13.5299	2.85	No	No	0	5	5
61	R:R:R94	R:R:Y45	17.1802	8.23	No	Yes	0	6	8
62	R:R:L188	R:R:R94	36.2812	10.93	Yes	No	0	3	6
63	R:R:I250	R:R:L246	12.9963	4.28	No	No	0	4	5
64	R:R:L188	R:R:Y97	13.9567	5.86	Yes	Yes	1	3	5
65	R:R:L118	R:R:R94	45.2136	6.07	No	No	0	6	6
66	R:R:Y221	R:R:Y305	27.611	4.96	Yes	Yes	6	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K37	5.3	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y119	28.93	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y123	13.21	1	Yes	No	0	7	0	1
L:L:?1	R:R:S169	8.86	1	Yes	No	0	5	0	1
L:L:?1	R:R:L198	7.43	1	Yes	No	0	4	0	1
L:L:?1	R:R:H284	8.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L287	5.2	1	Yes	No	0	4	0	1
R:R:H284	R:R:I33	9.28	1	Yes	No	4	1	1	2
R:R:F41	R:R:K37	9.93	1	Yes	Yes	5	4	2	1
R:R:K37	R:R:Y98	5.97	1	Yes	Yes	4	5	1	2
R:R:H284	R:R:K37	7.86	1	Yes	Yes	4	4	1	1
R:R:F41	R:R:Y98	22.69	1	Yes	Yes	5	5	2	2
R:R:L118	R:R:Y119	9.38	0	No	No	6	5	2	1
R:R:Y119	R:R:Y263	3.97	0	No	Yes	5	7	1	2
R:R:A205	R:R:Y123	5.34	0	No	No	5	7	2	1
R:R:M172	R:R:M201	5.78	0	No	Yes	8	5	2	1
R:R:K197	R:R:M201	4.32	0	No	Yes	3	5	2	1
R:R:L198	R:R:L271	4.15	0	No	No	4	5	1	2
R:R:H270	R:R:L287	5.14	0	No	No	4	4	2	1
R:R:C279	R:R:H284	5.9	0	No	Yes	1	4	2	1
R:R:M201	R:R:T200	3.01	0	Yes	No	5	3	1	2
R:R:L173	R:R:S115	3	0	No	No	5	6	1	2
L:L:?1	R:R:L173	2.97	1	Yes	No	0	5	0	1
L:L:?1	R:R:M201	1.52	1	Yes	Yes	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IXX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.76
Number of Linked Nodes	268
Number of Links	291
Number of Hubs	35
Number of Links mediated by Hubs	139
Number of Communities	8
Number of Nodes involved in Communities	35
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	46861
Length Of Smallest Path	3
Average Path Length	13.1724
Length of Longest Path	27
Minimum Path Strength	1.3
Average Path Strength	6.81715
Maximum Path Strength	20.63
Minimum Path Correlation	0.7
Average Path Correlation	0.927532
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.1375
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.9095
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LTD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LTD
Name	Leukotriene D4
Synonyms	Leukotriene D4 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine (R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine LTD4
Identifier
Formula	C25 H40 N2 O6 S
Molecular Weight	496.66
SMILES
PubChem	5280878
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	3
Total Bonds	73
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NS75
Sequence	>9IXX_nogp_Chain_R T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P Y K K S T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G S N W I F G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H P F R L L H V T S I R S A W I L C G I I W I L I M A S S I M L L D S G S E Q N G S V T S C L E L N L Y K I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V E V R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K V G L C K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N F K D R L K S A L R K G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6RZ6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ7	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ8	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2080365	-	-	2.7	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ9	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2770372	-	-	2.73	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	9IXX	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9IXX (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-		3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9JH5	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH5 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-		2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-		2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.