psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F41	3.44	Yes	Yes	1	0	5
2	L:L:?1	R:R:Y98	5.96	Yes	Yes	1	0	5
3	L:L:?1	R:R:Y119	17.22	Yes	No	0	0	5
4	L:L:?1	R:R:Y123	5.3	Yes	Yes	1	0	7
5	L:L:?1	R:R:Y127	4.64	Yes	Yes	1	0	5
6	L:L:?1	R:R:L165	5.47	Yes	No	0	0	4
7	L:L:?1	R:R:I166	5.64	Yes	No	1	0	7
8	L:L:?1	R:R:S169	3.39	Yes	No	0	0	5
9	L:L:?1	R:R:S170	11.03	Yes	No	0	0	7
10	L:L:?1	R:R:M201	12.78	Yes	No	0	0	5
11	L:L:?1	R:R:N202	3.88	Yes	Yes	1	0	5
12	L:L:?1	R:R:A205	4.45	Yes	No	1	0	5
13	L:L:?1	R:R:R267	5.49	Yes	Yes	1	0	5
14	L:L:?1	R:R:L291	7.82	Yes	No	0	0	5
15	R:R:E34	R:R:H284	3.69	No	Yes	0	4	4
16	R:R:H284	R:R:N35	7.65	Yes	No	0	4	5
17	R:R:F36	R:R:K37	7.44	No	No	0	6	4
18	R:R:F36	R:R:Y97	3.09	No	No	1	6	5
19	R:R:F36	R:R:Y98	12.38	No	Yes	1	6	5
20	R:R:R38	R:R:V288	9.15	No	No	0	4	5
21	R:R:E39	R:R:F40	11.66	No	No	0	4	5
22	R:R:F41	R:R:Y45	16.5	Yes	No	0	5	8
23	R:R:F41	R:R:Y98	11.35	Yes	Yes	1	5	5
24	R:R:L99	R:R:P42	3.28	No	No	0	4	5
25	R:R:I48	R:R:V44	3.07	Yes	Yes	0	7	5
26	R:R:L91	R:R:Y45	7.03	Yes	No	0	7	8
27	R:R:A296	R:R:I48	3.25	No	Yes	0	5	7
28	R:R:C299	R:R:I48	3.27	No	Yes	0	6	7
29	R:R:F49	R:R:V53	3.93	No	No	0	6	6
30	R:R:F49	R:R:P92	13	No	No	0	6	9
31	R:R:F50	R:R:W51	5.01	No	No	0	5	5
32	R:R:G55	R:R:L54	3.42	No	No	0	7	4
33	R:R:D84	R:R:N56	9.42	Yes	No	5	9	9
34	R:R:N56	R:R:P302	13.03	No	No	5	9	9
35	R:R:L58	R:R:V62	2.98	No	Yes	0	5	7
36	R:R:F63	R:R:S59	6.61	Yes	No	0	6	9
37	R:R:A81	R:R:S59	3.42	No	No	0	8	9
38	R:R:S59	R:R:Y306	11.45	No	No	0	9	6
39	R:R:A81	R:R:I60	3.25	No	Yes	0	8	7
40	R:R:I60	R:R:I82	2.94	Yes	No	0	7	5
41	R:R:L316	R:R:V62	7.45	No	Yes	0	5	7
42	R:R:F63	R:R:N74	6.04	Yes	No	0	6	7
43	R:R:F63	R:R:M77	8.71	Yes	No	0	6	8
44	R:R:F63	R:R:L78	3.65	Yes	No	0	6	5
45	R:R:F312	R:R:F63	5.36	No	Yes	0	8	6
46	R:R:D314	R:R:Y67	4.6	No	No	0	5	5
47	R:R:R315	R:R:Y67	14.4	No	No	0	4	5
48	R:R:S151	R:R:S72	4.89	No	No	0	6	6
49	R:R:V135	R:R:V73	4.81	No	No	2	8	7
50	R:R:N74	R:R:R315	4.82	No	No	0	7	4
51	R:R:F76	R:R:V75	5.24	Yes	Yes	2	7	6
52	R:R:I152	R:R:V75	3.07	No	Yes	2	3	6
53	R:R:A155	R:R:V75	5.09	No	Yes	0	7	6
54	R:R:V75	R:R:W156	13.48	Yes	Yes	2	6	4
55	R:R:F76	R:R:V131	7.87	Yes	No	0	7	6
56	R:R:F128	R:R:N79	14.5	Yes	No	2	8	9
57	R:R:N79	R:R:W156	6.78	No	Yes	2	9	4
58	R:R:C159	R:R:N79	11.02	Yes	No	2	7	9
59	R:R:D84	R:R:L80	4.07	Yes	No	0	9	9
60	R:R:S125	R:R:S83	3.26	No	No	0	9	8
61	R:R:F128	R:R:S83	3.96	Yes	No	0	8	8
62	R:R:D84	R:R:S125	4.42	Yes	No	0	9	9
63	R:R:A298	R:R:D84	6.18	No	Yes	0	8	9
64	R:R:D84	R:R:N301	4.04	Yes	No	0	9	9
65	R:R:D84	R:R:P302	3.22	Yes	No	5	9	9
66	R:R:F87	R:R:L91	7.31	Yes	Yes	0	6	7
67	R:R:F87	R:R:L118	3.65	Yes	No	0	6	6
68	R:R:F87	R:R:N121	6.04	Yes	No	0	6	8
69	R:R:F87	R:R:M122	4.98	Yes	No	0	6	7
70	R:R:R94	R:R:T90	9.06	No	Yes	0	6	7
71	R:R:M114	R:R:T90	3.01	No	Yes	0	5	7
72	R:R:L91	R:R:R94	7.29	Yes	No	0	7	6
73	R:R:F93	R:R:W104	8.02	No	Yes	0	6	8
74	R:R:L118	R:R:R94	19.44	No	No	0	6	6
75	R:R:D96	R:R:N103	12.12	No	No	0	3	4
76	R:R:Y97	R:R:Y98	7.94	No	Yes	1	5	5
77	R:R:W104	R:R:Y97	4.82	Yes	No	0	8	5
78	R:R:N103	R:R:R100	10.85	No	No	0	4	4
79	R:R:G107	R:R:W104	12.67	No	Yes	0	7	8
80	R:R:A110	R:R:W104	3.89	No	Yes	0	5	8
81	R:R:M114	R:R:W104	3.49	No	Yes	0	5	8
82	R:R:D108	R:R:G107	3.35	No	No	0	4	7
83	R:R:L109	R:R:R112	9.72	No	No	0	3	7
84	R:R:I113	R:R:M114	2.92	No	No	0	5	5
85	R:R:L173	R:R:S115	4.5	No	No	0	5	6
86	R:R:V120	R:R:Y116	21.45	No	Yes	6	5	5
87	R:R:M167	R:R:Y116	4.79	No	Yes	6	3	5
88	R:R:I171	R:R:Y116	3.63	No	Yes	0	4	5
89	R:R:L173	R:R:Y116	7.03	No	Yes	0	5	5
90	R:R:L174	R:R:Y116	8.21	No	Yes	0	5	5
91	R:R:L118	R:R:Y119	8.21	No	No	0	6	5
92	R:R:Y119	R:R:Y263	2.98	No	Yes	0	5	7
93	R:R:M167	R:R:V120	3.04	No	No	6	3	5
94	R:R:M122	R:R:Y123	5.99	No	Yes	0	7	7
95	R:R:M122	R:R:Y263	4.79	No	Yes	0	7	7
96	R:R:A205	R:R:Y123	4	No	Yes	1	5	7
97	R:R:H264	R:R:Y123	10.89	Yes	Yes	1	8	7
98	R:R:R267	R:R:Y123	6.17	Yes	Yes	1	5	7
99	R:R:F128	R:R:S124	5.28	Yes	No	2	8	7
100	R:R:S124	R:R:W163	12.36	No	No	2	7	9
101	R:R:I126	R:R:P213	3.39	No	Yes	0	7	9
102	R:R:F260	R:R:I126	8.79	No	No	0	9	7
103	R:R:I166	R:R:Y127	4.84	No	Yes	1	7	5
104	R:R:P213	R:R:Y127	4.17	Yes	Yes	0	9	5
105	R:R:C159	R:R:F128	4.19	Yes	Yes	2	7	8
106	R:R:F128	R:R:I162	8.79	Yes	No	0	8	6
107	R:R:F128	R:R:W163	14.03	Yes	No	2	8	9
108	R:R:F256	R:R:L129	4.87	No	No	0	9	8
109	R:R:L129	R:R:N301	4.12	No	No	0	8	9
110	R:R:L129	R:R:Y305	10.55	No	Yes	0	8	9
111	R:R:P213	R:R:T130	3.5	Yes	No	0	9	7
112	R:R:T130	R:R:T216	4.71	No	No	0	7	6
113	R:R:L132	R:R:Y305	5.86	No	Yes	0	9	9
114	R:R:L217	R:R:S133	3	No	No	3	7	9
115	R:R:C220	R:R:S133	5.16	No	No	0	6	9
116	R:R:S133	R:R:Y221	13.99	No	Yes	3	9	8
117	R:R:L138	R:R:V134	2.98	No	No	0	5	5
118	R:R:C220	R:R:V134	3.42	No	No	0	6	5
119	R:R:R136	R:R:Y221	9.26	No	Yes	3	9	8
120	R:R:R136	R:R:Y305	8.23	No	Yes	3	9	9
121	R:R:F137	R:R:V141	10.49	Yes	Yes	8	8	7
122	R:R:F137	R:R:H142	3.39	Yes	No	8	8	6
123	R:R:C220	R:R:F137	5.59	No	Yes	0	6	8
124	R:R:F137	R:R:I224	5.02	Yes	Yes	0	8	8
125	R:R:M140	R:R:V141	3.04	No	Yes	0	8	7
126	R:R:I224	R:R:M140	2.92	Yes	No	0	8	8
127	R:R:H142	R:R:V141	6.92	No	Yes	8	6	7
128	R:R:V141	R:R:V227	3.21	Yes	No	0	7	5
129	R:R:F144	R:R:P143	4.33	No	No	0	5	8
130	R:R:L147	R:R:R145	6.07	No	No	0	5	5
131	R:R:L146	R:R:V149	4.47	No	No	0	6	4
132	R:R:H148	R:R:V149	5.54	No	No	0	3	4
133	R:R:T150	R:R:V149	3.17	No	No	0	6	4
134	R:R:S154	R:R:T150	6.4	No	No	0	4	6
135	R:R:I152	R:R:S151	3.1	No	No	0	3	6
136	R:R:I152	R:R:W156	8.22	No	Yes	2	3	4
137	R:R:C159	R:R:W156	5.22	Yes	Yes	2	7	4
138	R:R:K197	R:R:Q199	8.14	No	No	0	3	3
139	R:R:K197	R:R:V276	3.04	No	No	0	3	1
140	R:R:N202	R:R:R267	14.46	Yes	Yes	1	5	5
141	R:R:N202	R:R:T268	10.24	Yes	No	0	5	6
142	R:R:L271	R:R:N202	5.49	No	Yes	0	5	5
143	R:R:L206	R:R:T268	4.42	No	No	0	5	6
144	R:R:C210	R:R:L261	4.76	No	Yes	0	8	5
145	R:R:C210	R:R:H264	8.85	No	Yes	0	8	8
146	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
147	R:R:F214	R:R:F215	5.36	Yes	No	0	6	3
148	R:R:F214	R:R:F256	6.43	Yes	No	0	6	9
149	R:R:F214	R:R:F257	5.36	Yes	No	9	6	5
150	R:R:F214	R:R:L261	7.31	Yes	Yes	9	6	5
151	R:R:L217	R:R:Y221	4.69	No	Yes	3	7	8
152	R:R:F256	R:R:L217	7.31	No	No	0	9	7
153	R:R:I224	R:R:Y221	3.63	Yes	Yes	0	8	8
154	R:R:I249	R:R:Y221	7.25	No	Yes	0	7	8
155	R:R:Y221	R:R:Y305	5.96	Yes	Yes	3	8	9
156	R:R:I225	R:R:L246	4.28	No	No	0	5	5
157	R:R:I225	R:R:I249	4.42	No	No	0	5	7
158	R:R:R239	R:R:R243	3.2	No	No	0	3	5
159	R:R:H242	R:R:S241	6.97	No	No	0	7	5
160	R:R:A308	R:R:K244	3.21	No	No	0	6	7
161	R:R:I251	R:R:I255	2.94	No	No	0	5	6
162	R:R:L304	R:R:T252	4.42	No	No	0	7	7
163	R:R:T252	R:R:Y305	4.99	No	Yes	0	7	9
164	R:R:F300	R:R:I255	3.77	No	No	0	7	6
165	R:R:I255	R:R:L304	8.56	No	No	0	6	7
166	R:R:F257	R:R:L261	6.09	No	Yes	9	5	5
167	R:R:C259	R:R:F260	11.17	No	No	7	8	9
168	R:R:C259	R:R:N297	9.45	No	No	7	8	9
169	R:R:F260	R:R:N297	10.87	No	No	7	9	9
170	R:R:H264	R:R:Y263	7.62	Yes	Yes	1	8	7
171	R:R:R267	R:R:Y263	8.23	Yes	Yes	1	5	7
172	R:R:L291	R:R:Y263	11.72	No	Yes	0	5	7
173	R:R:A294	R:R:Y263	6.67	No	Yes	0	8	7
174	R:R:H264	R:R:R267	5.64	Yes	Yes	1	8	5
175	R:R:L266	R:R:V269	2.98	No	No	0	5	5
176	R:R:T273	R:R:V269	4.76	No	No	0	3	5
177	R:R:H270	R:R:W274	15.87	No	Yes	4	4	3
178	R:R:H270	R:R:H284	13.14	No	Yes	4	4	4
179	R:R:H270	R:R:L287	7.71	No	No	0	4	4
180	R:R:T273	R:R:W274	20.62	No	Yes	0	3	3
181	R:R:C279	R:R:W274	22.2	No	Yes	4	1	3
182	R:R:L283	R:R:W274	23.92	No	Yes	0	4	3
183	R:R:H284	R:R:W274	11.64	Yes	Yes	4	4	3
184	R:R:C279	R:R:H284	7.37	No	Yes	4	1	4
185	R:R:K280	R:R:R282	3.71	No	No	0	3	3
186	R:R:A296	R:R:F300	4.16	No	No	0	5	7
187	R:R:N297	R:R:N301	14.98	No	No	0	9	9
188	R:R:P302	R:R:Y306	6.95	No	No	0	9	6
189	R:R:F307	R:R:L303	6.09	No	No	0	7	6
190	R:R:F312	R:R:Y306	21.66	No	No	0	8	6
191	R:R:E310	R:R:K313	4.05	No	No	0	5	8
192	R:R:I195	R:R:K275	2.91	No	No	0	2	1
193	R:R:G209	R:R:Y123	2.9	No	Yes	0	5	7
194	R:R:I60	R:R:L64	2.85	Yes	No	0	7	3
195	R:R:I60	R:R:L85	2.85	Yes	No	0	7	7
196	R:R:I88	R:R:L85	2.85	No	No	0	6	7
197	R:R:L173	R:R:M201	2.83	No	No	0	5	5
198	R:R:Q199	R:R:T272	2.83	No	No	0	3	4
199	R:R:C111	R:R:R112	2.79	No	No	0	9	7
200	R:R:L138	R:R:L147	2.77	No	No	0	5	5
201	R:R:L229	R:R:L246	2.77	No	No	0	4	5
202	R:R:D281	R:R:K280	2.77	No	No	0	2	3
203	R:R:L86	R:R:N121	2.75	No	No	0	6	8
204	R:R:F312	R:R:V62	2.62	No	Yes	0	8	7
205	R:R:F76	R:R:V73	2.62	Yes	No	2	7	7
206	R:R:F76	R:R:V135	2.62	Yes	No	2	7	8
207	R:R:C299	R:R:W51	2.61	No	No	0	6	5
208	R:R:C111	R:R:W104	2.61	No	Yes	0	9	8
209	R:R:D314	R:R:E310	2.6	No	No	0	5	5
210	R:R:R153	R:R:T150	2.59	No	No	0	4	6
211	R:R:V208	R:R:Y127	2.52	No	Yes	0	4	5
212	R:R:K285	R:R:R38	2.48	No	No	0	1	4
213	R:R:F50	R:R:L54	2.44	No	No	0	5	4
214	R:R:F137	R:R:L223	2.44	Yes	Yes	0	8	4
215	R:R:L223	R:R:R226	2.43	Yes	No	0	4	4
216	R:R:I47	R:R:W51	2.35	No	No	0	5	5
217	R:R:L253	R:R:Y221	2.34	No	Yes	0	7	8
218	R:R:F41	R:R:R38	2.14	Yes	No	0	5	4
219	R:R:C299	R:R:G52	1.96	No	No	0	6	8
220	R:R:C159	R:R:G160	1.96	Yes	No	0	7	3
221	R:R:P262	R:R:T290	1.75	No	No	0	9	6
222	R:R:A292	R:R:V44	1.7	No	Yes	0	5	5
223	R:R:A308	R:R:T248	1.68	No	No	0	6	7
224	R:R:L91	R:R:P92	1.64	Yes	No	0	7	9
225	R:R:L261	R:R:P262	1.64	Yes	No	0	5	9
226	R:R:A295	R:R:I48	1.62	No	Yes	0	7	7
227	R:R:A139	R:R:M140	1.61	No	No	0	8	8
228	R:R:S89	R:R:T90	1.6	No	Yes	0	5	7
229	R:R:S117	R:R:T90	1.6	No	Yes	0	5	7
230	R:R:T71	R:R:V73	1.59	No	No	0	7	7
231	R:R:A95	R:R:L46	1.58	No	No	0	6	5
232	R:R:P66	R:R:Q65	1.58	No	No	0	5	5
233	R:R:A245	R:R:L228	1.58	No	No	0	7	8
234	R:R:A286	R:R:L266	1.58	No	No	0	5	5
235	R:R:T248	R:R:T252	1.57	No	No	0	7	7
236	L:L:?1	R:R:L287	1.56	Yes	No	0	0	4
237	R:R:I105	R:R:S102	1.55	No	No	0	4	5
238	R:R:I43	R:R:V44	1.54	No	Yes	0	4	5
239	R:R:I289	R:R:V288	1.54	No	No	0	5	5
240	R:R:H142	R:R:P143	1.53	No	No	0	6	8
241	R:R:I204	R:R:T200	1.52	No	No	0	3	3
242	R:R:I251	R:R:T247	1.52	No	No	0	5	6
243	R:R:N74	R:R:S70	1.49	No	No	0	7	6
244	R:R:I157	R:R:I161	1.47	No	No	0	3	3
245	R:R:I225	R:R:I250	1.47	No	No	0	5	4
246	R:R:I250	R:R:I254	1.47	No	No	0	4	4
247	R:R:L266	R:R:T265	1.47	No	No	0	5	5
248	R:R:L271	R:R:T272	1.47	No	No	0	5	4
249	R:R:A139	R:R:H148	1.46	No	No	0	8	3
250	R:R:I164	R:R:M167	1.46	No	No	0	3	3
251	R:R:F41	R:R:P42	1.44	Yes	No	0	5	5
252	R:R:K68	R:R:K69	1.44	No	No	0	6	6
253	R:R:Q65	R:R:V62	1.43	No	Yes	0	5	7
254	R:R:I219	R:R:L223	1.43	No	Yes	0	3	4
255	R:R:I224	R:R:L228	1.43	Yes	No	0	8	8
256	R:R:I254	R:R:L258	1.43	No	No	0	4	6
257	R:R:L198	R:R:M201	1.41	No	No	0	4	5
258	R:R:K275	R:R:L271	1.41	No	No	0	1	5
259	R:R:A308	R:R:F307	1.39	No	No	0	6	7
260	R:R:L222	R:R:L223	1.38	No	Yes	0	3	4
261	R:R:D281	R:R:N35	1.35	No	No	0	2	5
262	R:R:F214	R:R:S218	1.32	Yes	No	0	6	4
263	R:R:F40	R:R:V44	1.31	No	Yes	0	5	5
264	R:R:R239	R:R:V240	1.31	No	No	0	3	4
265	R:R:H242	R:R:L228	1.29	No	No	0	7	8
266	R:R:H242	R:R:L238	1.29	No	No	0	7	2
267	R:R:T272	R:R:Y203	1.25	No	No	0	4	4
268	R:R:F49	R:R:L46	1.22	No	No	0	6	5
269	R:R:L99	R:R:R100	1.21	No	No	0	4	4
270	R:R:F106	R:R:N103	1.21	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.538	15	1	0
2	R:R:F41	6.974	5	1	5
3	R:R:V44	1.905	4	0	5
4	R:R:I48	2.8025	4	0	7
5	R:R:I60	2.9725	4	0	7
6	R:R:V62	3.62	4	0	7
7	R:R:F63	6.074	5	0	6
8	R:R:V75	6.72	4	2	6
9	R:R:F76	4.5875	4	2	7
10	R:R:D84	5.225	6	5	9
11	R:R:F87	5.495	4	0	6
12	R:R:T90	3.8175	4	0	7
13	R:R:L91	5.8175	4	0	7
14	R:R:Y98	9.4075	4	1	5
15	R:R:W104	5.91667	6	0	8
16	R:R:Y116	9.022	5	6	5
17	R:R:Y123	5.875	6	1	7
18	R:R:Y127	4.0425	4	1	5
19	R:R:F128	8.45833	6	2	8
20	R:R:F137	5.386	5	8	8
21	R:R:V141	5.915	4	8	7
22	R:R:W156	8.425	4	2	4
23	R:R:C159	5.5975	4	2	7
24	R:R:N202	8.5175	4	1	5
25	R:R:P213	3.585	4	0	9
26	R:R:F214	5.156	5	9	6
27	R:R:Y221	6.73143	7	3	8
28	R:R:L223	1.92	4	0	4
29	R:R:I224	3.25	4	0	8
30	R:R:L261	4.95	4	9	5
31	R:R:Y263	7.00167	6	1	7
32	R:R:H264	8.25	4	1	8
33	R:R:R267	7.998	5	1	5
34	R:R:W274	18.85	5	4	3
35	R:R:H284	8.698	5	4	4
36	R:R:Y305	7.118	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L287	40.0961	1.56	Yes	No	0	0	4
2	R:R:H270	R:R:L287	38.1425	7.71	No	No	0	4	4
3	R:R:H270	R:R:H284	16.849	13.14	No	Yes	4	4	4
4	L:L:?1	R:R:Y98	30.6632	5.96	Yes	Yes	1	0	5
5	R:R:Y97	R:R:Y98	25.1185	7.94	No	Yes	1	5	5
6	L:L:?1	R:R:F41	30.9856	3.44	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y123	39.1351	5.3	Yes	Yes	1	0	7
8	R:R:H264	R:R:Y123	44.1613	10.89	Yes	Yes	1	8	7
9	R:R:C210	R:R:H264	100	8.85	No	Yes	0	8	8
10	R:R:C210	R:R:L261	99.9115	4.76	No	Yes	0	8	5
11	R:R:F214	R:R:L261	98.4953	7.31	Yes	Yes	9	6	5
12	R:R:F214	R:R:F256	99.1971	6.43	Yes	No	0	6	9
13	R:R:F256	R:R:L129	46.0707	4.87	No	No	0	9	8
14	R:R:L129	R:R:Y305	77.1828	10.55	No	Yes	0	8	9
15	R:R:T252	R:R:Y305	57.8808	4.99	No	Yes	0	7	9
16	R:R:L304	R:R:T252	45.6281	4.42	No	No	0	7	7
17	R:R:I255	R:R:L304	43.4785	8.56	No	No	0	6	7
18	R:R:F300	R:R:I255	36.916	3.77	No	No	0	7	6
19	R:R:A296	R:R:F300	34.7032	4.16	No	No	0	5	7
20	R:R:A296	R:R:I48	32.4777	3.25	No	Yes	0	5	7
21	R:R:I48	R:R:V44	11.8796	3.07	Yes	Yes	0	7	5
22	L:L:?1	R:R:R267	35.3164	5.49	Yes	Yes	1	0	5
23	R:R:H264	R:R:R267	41.0255	5.64	Yes	Yes	1	8	5
24	L:L:?1	R:R:Y127	57.767	4.64	Yes	Yes	1	0	5
25	R:R:P213	R:R:Y127	59.2337	4.17	Yes	Yes	0	9	5
26	R:R:I126	R:R:P213	60.1947	3.39	No	Yes	0	7	9
27	R:R:F260	R:R:I126	60.4792	8.79	No	No	0	9	7
28	R:R:F260	R:R:N297	60.1062	10.87	No	No	7	9	9
29	R:R:N297	R:R:N301	61.4213	14.98	No	No	0	9	9
30	R:R:L129	R:R:N301	61.1431	4.12	No	No	0	8	9
31	R:R:F41	R:R:P42	14.6741	1.44	Yes	No	0	5	5
32	R:R:L99	R:R:P42	12.259	3.28	No	No	0	4	5
33	R:R:C299	R:R:I48	16.5455	3.27	No	Yes	0	6	7
34	R:R:L91	R:R:P92	11.3738	1.64	Yes	No	0	7	9
35	R:R:C299	R:R:W51	11.8796	2.61	No	No	0	6	5
36	R:R:D84	R:R:N301	89.113	4.04	Yes	No	0	9	9
37	R:R:D84	R:R:P302	51.6786	3.22	Yes	No	5	9	9
38	R:R:P302	R:R:Y306	50.5595	6.95	No	No	0	9	6
39	R:R:F312	R:R:Y306	23.8983	21.66	No	No	0	8	6
40	R:R:S59	R:R:Y306	25.9657	11.45	No	No	0	9	6
41	R:R:F63	R:R:S59	15.7109	6.61	Yes	No	0	6	9
42	R:R:A81	R:R:S59	10.0462	3.42	No	No	0	8	9
43	R:R:F63	R:R:N74	21.7235	6.04	Yes	No	0	6	7
44	R:R:N74	R:R:R315	15.8311	4.82	No	No	0	7	4
45	R:R:R315	R:R:Y67	12.6952	14.4	No	No	0	4	5
46	R:R:F312	R:R:F63	15.2621	5.36	No	Yes	0	8	6
47	R:R:D84	R:R:S125	47.2719	4.42	Yes	No	0	9	9
48	R:R:S125	R:R:S83	45.9189	3.26	No	No	0	9	8
49	R:R:F128	R:R:S83	44.5533	3.96	Yes	No	0	8	8
50	R:R:F128	R:R:N79	18.5876	14.5	Yes	No	2	8	9
51	R:R:N79	R:R:W156	17.0766	6.78	No	Yes	2	9	4
52	R:R:C159	R:R:F128	20.3705	4.19	Yes	Yes	2	7	8
53	R:R:C159	R:R:W156	17.3484	5.22	Yes	Yes	2	7	4
54	R:R:V75	R:R:W156	21.9574	13.48	Yes	Yes	2	6	4
55	R:R:F76	R:R:V75	15.7426	5.24	Yes	Yes	2	7	6
56	R:R:L118	R:R:Y119	10.7922	8.21	No	No	0	6	5
57	R:R:M122	R:R:Y123	11.7026	5.99	No	Yes	0	7	7
58	R:R:F87	R:R:M122	16.8426	4.98	Yes	No	0	6	7
59	R:R:W104	R:R:Y97	22.9626	4.82	Yes	No	0	8	5
60	L:L:?1	R:R:M201	23.4811	12.78	Yes	No	0	0	5
61	R:R:L173	R:R:M201	19.0175	2.83	No	No	0	5	5
62	R:R:L173	R:R:Y116	14.535	7.03	No	Yes	0	5	5
63	R:R:F256	R:R:L217	60.1631	7.31	No	No	0	9	7
64	R:R:L217	R:R:S133	20.4084	3	No	No	3	7	9
65	R:R:C220	R:R:S133	22.5833	5.16	No	No	0	6	9
66	R:R:L217	R:R:Y221	38.623	4.69	No	Yes	3	7	8
67	R:R:C220	R:R:V134	10.1663	3.42	No	No	0	6	5
68	R:R:C220	R:R:F137	11.8543	5.59	No	Yes	0	6	8
69	R:R:I224	R:R:Y221	47.4426	3.63	Yes	Yes	0	8	8
70	R:R:F137	R:R:I224	19.6561	5.02	Yes	Yes	0	8	8
71	R:R:I224	R:R:M140	18.9985	2.92	Yes	No	0	8	8
72	R:R:A139	R:R:M140	14.2062	1.61	No	No	0	8	8
73	R:R:A139	R:R:H148	12.1768	1.46	No	No	0	8	3
74	R:R:H148	R:R:V149	10.3939	5.54	No	No	0	3	4
75	L:L:?1	R:R:N202	10.6278	3.88	Yes	Yes	1	0	5
76	R:R:L271	R:R:N202	13.2705	5.49	No	Yes	0	5	5
77	R:R:I249	R:R:Y221	13.8332	7.25	No	Yes	0	7	8
78	R:R:I225	R:R:I249	12.1135	4.42	No	No	0	5	7
79	R:R:T248	R:R:T252	11.5951	1.57	No	No	0	7	7
80	R:R:H270	R:R:W274	19.2578	15.87	No	Yes	4	4	3
81	R:R:T273	R:R:W274	12.3095	20.62	No	Yes	0	3	3
82	R:R:F137	R:R:L223	12.6636	2.44	Yes	Yes	0	8	4
83	R:R:H264	R:R:Y263	14.9333	7.62	Yes	Yes	1	8	7
84	R:R:Y221	R:R:Y305	28.3619	5.96	Yes	Yes	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F41	3.44	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y98	5.96	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y119	17.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y123	5.3	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y127	4.64	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L165	5.47	1	Yes	No	0	4	0	1
L:L:?1	R:R:I166	5.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:S169	3.39	1	Yes	No	0	5	0	1
L:L:?1	R:R:S170	11.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:M201	12.78	1	Yes	No	0	5	0	1
L:L:?1	R:R:N202	3.88	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:A205	4.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:R267	5.49	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L291	7.82	1	Yes	No	0	5	0	1
R:R:F36	R:R:Y97	3.09	1	No	No	6	5	2	2
R:R:F36	R:R:Y98	12.38	1	No	Yes	6	5	2	1
R:R:F41	R:R:Y45	16.5	1	Yes	No	5	8	1	2
R:R:F41	R:R:Y98	11.35	1	Yes	Yes	5	5	1	1
R:R:Y97	R:R:Y98	7.94	1	No	Yes	5	5	2	1
R:R:L118	R:R:Y119	8.21	0	No	No	6	5	2	1
R:R:Y119	R:R:Y263	2.98	0	No	Yes	5	7	1	2
R:R:M122	R:R:Y123	5.99	0	No	Yes	7	7	2	1
R:R:M122	R:R:Y263	4.79	0	No	Yes	7	7	2	2
R:R:A205	R:R:Y123	4	1	No	Yes	5	7	1	1
R:R:H264	R:R:Y123	10.89	1	Yes	Yes	8	7	2	1
R:R:R267	R:R:Y123	6.17	1	Yes	Yes	5	7	1	1
R:R:I166	R:R:Y127	4.84	1	No	Yes	7	5	1	1
R:R:P213	R:R:Y127	4.17	0	Yes	Yes	9	5	2	1
R:R:N202	R:R:R267	14.46	1	Yes	Yes	5	5	1	1
R:R:N202	R:R:T268	10.24	1	Yes	No	5	6	1	2
R:R:L271	R:R:N202	5.49	0	No	Yes	5	5	2	1
R:R:H264	R:R:Y263	7.62	1	Yes	Yes	8	7	2	2
R:R:R267	R:R:Y263	8.23	1	Yes	Yes	5	7	1	2
R:R:L291	R:R:Y263	11.72	0	No	Yes	5	7	1	2
R:R:H264	R:R:R267	5.64	1	Yes	Yes	8	5	2	1
R:R:H270	R:R:L287	7.71	4	No	No	4	4	2	1
R:R:G209	R:R:Y123	2.9	0	No	Yes	5	7	2	1
R:R:L173	R:R:M201	2.83	0	No	No	5	5	2	1
R:R:V208	R:R:Y127	2.52	0	No	Yes	4	5	2	1
R:R:F41	R:R:R38	2.14	1	Yes	No	5	4	1	2
L:L:?1	R:R:L287	1.56	1	Yes	No	0	4	0	1
R:R:F41	R:R:P42	1.44	1	Yes	No	5	5	1	2
R:R:L198	R:R:M201	1.41	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JH6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	242
Number of Links	270
Number of Hubs	36
Number of Links mediated by Hubs	150
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	42490
Length Of Smallest Path	3
Average Path Length	13.6149
Length of Longest Path	27
Minimum Path Strength	1.29
Average Path Strength	6.16377
Maximum Path Strength	23.06
Minimum Path Correlation	0.7
Average Path Correlation	0.91341
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	42.1948
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.6506
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NS75
Sequence	>9JH6_nogp_Chain_R E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P Y K K S T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G S N W I F G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H P F R L L H V T S I R S A W I L C G I I W I L I M A S S I M L L D K I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K V G L C K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N F K D R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6RZ6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ7	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ8	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2080365	-	-	2.7	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ9	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2770372	-	-	2.73	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	9JH5	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH5 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-		2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-		2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9IXX	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9IXX (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-		3.15	2025-04-02	doi.org/10.1073/pnas.2417148122

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