psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F41	5.02	Yes	Yes	1	0	5
2	L:L:?1	R:R:Y98	8.69	Yes	Yes	1	0	5
3	L:L:?1	R:R:Y119	25.1	Yes	No	0	0	5
4	L:L:?1	R:R:Y123	7.72	Yes	Yes	1	0	7
5	L:L:?1	R:R:Y127	6.76	Yes	Yes	1	0	5
6	L:L:?1	R:R:L165	7.98	Yes	No	0	0	4
7	L:L:?1	R:R:I166	8.23	Yes	No	1	0	7
8	L:L:?1	R:R:S169	4.95	Yes	No	0	0	5
9	L:L:?1	R:R:S170	16.08	Yes	No	0	0	7
10	L:L:?1	R:R:L173	3.42	Yes	No	0	0	5
11	L:L:?1	R:R:M201	18.63	Yes	No	0	0	5
12	L:L:?1	R:R:N202	5.65	Yes	Yes	1	0	5
13	L:L:?1	R:R:A205	6.49	Yes	No	1	0	5
14	L:L:?1	R:R:R267	8	Yes	Yes	1	0	5
15	L:L:?1	R:R:L291	11.4	Yes	No	0	0	5
16	R:R:E34	R:R:H284	3.69	No	Yes	0	4	4
17	R:R:H284	R:R:N35	7.65	Yes	No	0	4	5
18	R:R:F36	R:R:K37	7.44	No	No	0	6	4
19	R:R:F36	R:R:Y98	12.38	No	Yes	0	6	5
20	R:R:R38	R:R:V288	9.15	No	No	0	4	5
21	R:R:E39	R:R:F40	11.66	No	No	0	4	5
22	R:R:F41	R:R:Y45	16.5	Yes	No	0	5	8
23	R:R:F41	R:R:Y98	11.35	Yes	Yes	1	5	5
24	R:R:L99	R:R:P42	3.28	No	No	0	4	5
25	R:R:L91	R:R:Y45	7.03	Yes	No	0	7	8
26	R:R:A296	R:R:I48	3.25	No	Yes	0	5	7
27	R:R:C299	R:R:I48	3.27	No	Yes	0	6	7
28	R:R:F49	R:R:V53	3.93	No	No	0	6	6
29	R:R:F49	R:R:P92	13	No	No	0	6	9
30	R:R:F50	R:R:W51	5.01	No	No	0	5	5
31	R:R:G55	R:R:L54	3.42	No	No	0	7	4
32	R:R:D84	R:R:N56	9.42	Yes	No	4	9	9
33	R:R:N56	R:R:P302	13.03	No	No	4	9	9
34	R:R:F63	R:R:S59	6.61	Yes	No	0	6	9
35	R:R:A81	R:R:S59	3.42	No	No	0	8	9
36	R:R:S59	R:R:Y306	11.45	No	No	0	9	6
37	R:R:A81	R:R:I60	3.25	No	Yes	0	8	7
38	R:R:L316	R:R:V62	7.45	No	Yes	0	5	7
39	R:R:F63	R:R:N74	6.04	Yes	No	0	6	7
40	R:R:F63	R:R:M77	8.71	Yes	No	0	6	8
41	R:R:F63	R:R:L78	3.65	Yes	No	0	6	5
42	R:R:F312	R:R:F63	5.36	No	Yes	0	8	6
43	R:R:D314	R:R:Y67	4.6	No	No	0	5	5
44	R:R:R315	R:R:Y67	14.4	No	No	0	4	5
45	R:R:S151	R:R:S72	4.89	No	No	0	6	6
46	R:R:V135	R:R:V73	4.81	No	No	5	8	7
47	R:R:N74	R:R:R315	4.82	No	No	0	7	4
48	R:R:F76	R:R:V75	5.24	Yes	No	0	7	6
49	R:R:A155	R:R:V75	5.09	No	No	0	7	6
50	R:R:V75	R:R:W156	13.48	No	Yes	0	6	4
51	R:R:F76	R:R:V131	7.87	Yes	No	0	7	6
52	R:R:F128	R:R:N79	14.5	Yes	No	2	8	9
53	R:R:N79	R:R:W156	6.78	No	Yes	2	9	4
54	R:R:C159	R:R:N79	11.02	Yes	No	2	7	9
55	R:R:D84	R:R:L80	4.07	Yes	No	0	9	9
56	R:R:S125	R:R:S83	3.26	No	No	0	9	8
57	R:R:F128	R:R:S83	3.96	Yes	No	0	8	8
58	R:R:D84	R:R:S125	4.42	Yes	No	0	9	9
59	R:R:A298	R:R:D84	6.18	No	Yes	0	8	9
60	R:R:D84	R:R:N301	4.04	Yes	No	0	9	9
61	R:R:D84	R:R:P302	3.22	Yes	No	4	9	9
62	R:R:F87	R:R:L91	7.31	Yes	Yes	0	6	7
63	R:R:F87	R:R:L118	3.65	Yes	No	0	6	6
64	R:R:F87	R:R:N121	6.04	Yes	No	0	6	8
65	R:R:F87	R:R:M122	4.98	Yes	No	0	6	7
66	R:R:R94	R:R:T90	9.06	No	No	0	6	7
67	R:R:L91	R:R:R94	7.29	Yes	No	0	7	6
68	R:R:F93	R:R:W104	8.02	No	Yes	0	6	8
69	R:R:L118	R:R:R94	19.44	No	No	0	6	6
70	R:R:D96	R:R:N103	12.12	No	No	0	3	4
71	R:R:Y97	R:R:Y98	7.94	No	Yes	0	5	5
72	R:R:W104	R:R:Y97	4.82	Yes	No	0	8	5
73	R:R:N103	R:R:R100	10.85	No	No	0	4	4
74	R:R:G107	R:R:W104	12.67	No	Yes	0	7	8
75	R:R:A110	R:R:W104	3.89	No	Yes	0	5	8
76	R:R:M114	R:R:W104	3.49	No	Yes	0	5	8
77	R:R:D108	R:R:G107	3.35	No	No	0	4	7
78	R:R:L109	R:R:R112	9.72	No	No	0	3	7
79	R:R:L173	R:R:S115	4.5	No	No	0	5	6
80	R:R:V120	R:R:Y116	21.45	No	Yes	0	5	5
81	R:R:M167	R:R:Y116	4.79	No	Yes	0	3	5
82	R:R:I171	R:R:Y116	3.63	No	Yes	0	4	5
83	R:R:L173	R:R:Y116	7.03	No	Yes	0	5	5
84	R:R:L174	R:R:Y116	8.21	No	Yes	0	5	5
85	R:R:L118	R:R:Y119	8.21	No	No	0	6	5
86	R:R:M122	R:R:Y123	5.99	No	Yes	0	7	7
87	R:R:M122	R:R:Y263	4.79	No	Yes	0	7	7
88	R:R:A205	R:R:Y123	4	No	Yes	1	5	7
89	R:R:H264	R:R:Y123	10.89	Yes	Yes	1	8	7
90	R:R:R267	R:R:Y123	6.17	Yes	Yes	1	5	7
91	R:R:F128	R:R:S124	5.28	Yes	No	2	8	7
92	R:R:S124	R:R:W163	12.36	No	No	2	7	9
93	R:R:I126	R:R:P213	3.39	No	Yes	0	7	9
94	R:R:F260	R:R:I126	8.79	No	No	0	9	7
95	R:R:I166	R:R:Y127	4.84	No	Yes	1	7	5
96	R:R:P213	R:R:Y127	4.17	Yes	Yes	0	9	5
97	R:R:C159	R:R:F128	4.19	Yes	Yes	2	7	8
98	R:R:F128	R:R:I162	8.79	Yes	No	0	8	6
99	R:R:F128	R:R:W163	14.03	Yes	No	2	8	9
100	R:R:F256	R:R:L129	4.87	No	No	0	9	8
101	R:R:L129	R:R:N301	4.12	No	No	0	8	9
102	R:R:L129	R:R:Y305	10.55	No	Yes	0	8	9
103	R:R:P213	R:R:T130	3.5	Yes	No	0	9	7
104	R:R:T130	R:R:T216	4.71	No	No	0	7	6
105	R:R:L132	R:R:Y305	5.86	No	Yes	0	9	9
106	R:R:C220	R:R:S133	5.16	No	No	0	6	9
107	R:R:S133	R:R:Y221	13.99	No	Yes	0	9	8
108	R:R:C220	R:R:V134	3.42	No	No	0	6	5
109	R:R:R136	R:R:Y221	9.26	No	Yes	7	9	8
110	R:R:R136	R:R:Y305	8.23	No	Yes	7	9	9
111	R:R:F137	R:R:V141	10.49	Yes	Yes	8	8	7
112	R:R:F137	R:R:H142	3.39	Yes	No	8	8	6
113	R:R:C220	R:R:F137	5.59	No	Yes	0	6	8
114	R:R:F137	R:R:I224	5.02	Yes	No	0	8	8
115	R:R:H142	R:R:V141	6.92	No	Yes	8	6	7
116	R:R:V141	R:R:V227	3.21	Yes	No	0	7	5
117	R:R:F144	R:R:P143	4.33	No	No	0	5	8
118	R:R:L147	R:R:R145	6.07	No	No	0	5	5
119	R:R:L146	R:R:V149	4.47	No	No	0	6	4
120	R:R:H148	R:R:V149	5.54	No	No	0	3	4
121	R:R:T150	R:R:V149	3.17	No	No	0	6	4
122	R:R:S154	R:R:T150	6.4	No	No	0	4	6
123	R:R:I152	R:R:S151	3.1	No	No	0	3	6
124	R:R:I152	R:R:W156	8.22	No	Yes	0	3	4
125	R:R:C159	R:R:W156	5.22	Yes	Yes	2	7	4
126	R:R:K197	R:R:Q199	8.14	No	No	0	3	3
127	R:R:N202	R:R:R267	14.46	Yes	Yes	1	5	5
128	R:R:N202	R:R:T268	10.24	Yes	No	0	5	6
129	R:R:L271	R:R:N202	5.49	No	Yes	0	5	5
130	R:R:L206	R:R:T268	4.42	No	No	0	5	6
131	R:R:C210	R:R:L261	4.76	No	Yes	0	8	5
132	R:R:C210	R:R:H264	8.85	No	Yes	0	8	8
133	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
134	R:R:F214	R:R:F215	5.36	Yes	No	0	6	3
135	R:R:F214	R:R:F256	6.43	Yes	No	0	6	9
136	R:R:F214	R:R:F257	5.36	Yes	No	9	6	5
137	R:R:F214	R:R:L261	7.31	Yes	Yes	9	6	5
138	R:R:L217	R:R:Y221	4.69	No	Yes	0	7	8
139	R:R:F256	R:R:L217	7.31	No	No	0	9	7
140	R:R:I224	R:R:Y221	3.63	No	Yes	0	8	8
141	R:R:I249	R:R:Y221	7.25	No	Yes	0	7	8
142	R:R:Y221	R:R:Y305	5.96	Yes	Yes	7	8	9
143	R:R:I225	R:R:L246	4.28	No	No	0	5	5
144	R:R:I225	R:R:I249	4.42	No	No	0	5	7
145	R:R:R239	R:R:R243	3.2	No	No	0	3	5
146	R:R:H242	R:R:S241	6.97	No	No	0	7	5
147	R:R:A308	R:R:K244	3.21	No	No	0	6	7
148	R:R:L304	R:R:T252	4.42	No	No	0	7	7
149	R:R:T252	R:R:Y305	4.99	No	Yes	0	7	9
150	R:R:F300	R:R:I255	3.77	No	No	0	7	6
151	R:R:I255	R:R:L304	8.56	No	No	0	6	7
152	R:R:F257	R:R:L261	6.09	No	Yes	9	5	5
153	R:R:C259	R:R:F260	11.17	No	No	6	8	9
154	R:R:C259	R:R:N297	9.45	No	No	6	8	9
155	R:R:F260	R:R:N297	10.87	No	No	6	9	9
156	R:R:H264	R:R:Y263	7.62	Yes	Yes	1	8	7
157	R:R:R267	R:R:Y263	8.23	Yes	Yes	1	5	7
158	R:R:L291	R:R:Y263	11.72	No	Yes	0	5	7
159	R:R:A294	R:R:Y263	6.67	No	Yes	0	8	7
160	R:R:H264	R:R:R267	5.64	Yes	Yes	1	8	5
161	R:R:T273	R:R:V269	4.76	No	No	0	3	5
162	R:R:H270	R:R:W274	15.87	No	Yes	3	4	3
163	R:R:H270	R:R:H284	13.14	No	Yes	3	4	4
164	R:R:H270	R:R:L287	7.71	No	No	0	4	4
165	R:R:T273	R:R:W274	20.62	No	Yes	0	3	3
166	R:R:C279	R:R:W274	22.2	No	Yes	3	1	3
167	R:R:L283	R:R:W274	23.92	No	Yes	0	4	3
168	R:R:H284	R:R:W274	11.64	Yes	Yes	3	4	3
169	R:R:C279	R:R:H284	7.37	No	Yes	3	1	4
170	R:R:K280	R:R:R282	3.71	No	No	0	3	3
171	R:R:A296	R:R:F300	4.16	No	No	0	5	7
172	R:R:N297	R:R:N301	14.98	No	No	0	9	9
173	R:R:P302	R:R:Y306	6.95	No	No	0	9	6
174	R:R:F307	R:R:L303	6.09	No	No	0	7	6
175	R:R:F312	R:R:Y306	21.66	No	No	0	8	6
176	R:R:E310	R:R:K313	4.05	No	No	0	5	8
177	R:R:I48	R:R:V44	3.07	Yes	Yes	0	7	5
178	R:R:M140	R:R:V141	3.04	No	Yes	0	8	7
179	R:R:K197	R:R:V276	3.04	No	No	0	3	1
180	R:R:L58	R:R:V62	2.98	No	Yes	0	5	7
181	R:R:L138	R:R:V134	2.98	No	No	0	5	5
182	R:R:L266	R:R:V269	2.98	No	No	0	5	5
183	R:R:I60	R:R:I82	2.94	Yes	No	0	7	5
184	R:R:I251	R:R:I255	2.94	No	No	0	5	6
185	R:R:I113	R:R:M114	2.92	No	No	0	5	5
186	R:R:I195	R:R:K275	2.91	No	No	0	2	1
187	R:R:G209	R:R:Y123	2.9	No	Yes	0	5	7
188	R:R:I60	R:R:L64	2.85	Yes	No	0	7	3
189	R:R:I60	R:R:L85	2.85	Yes	No	0	7	7
190	R:R:I88	R:R:L85	2.85	No	No	0	6	7
191	R:R:Q199	R:R:T272	2.83	No	No	0	3	4
192	R:R:C111	R:R:R112	2.79	No	No	0	9	7
193	R:R:L138	R:R:L147	2.77	No	No	0	5	5
194	R:R:L229	R:R:L246	2.77	No	No	0	4	5
195	R:R:D281	R:R:K280	2.77	No	No	0	2	3
196	R:R:L86	R:R:N121	2.75	No	No	0	6	8
197	R:R:F312	R:R:V62	2.62	No	Yes	0	8	7
198	R:R:F76	R:R:V73	2.62	Yes	No	5	7	7
199	R:R:F76	R:R:V135	2.62	Yes	No	5	7	8
200	R:R:C299	R:R:W51	2.61	No	No	0	6	5
201	R:R:C111	R:R:W104	2.61	No	Yes	0	9	8
202	R:R:D314	R:R:E310	2.6	No	No	0	5	5
203	R:R:R153	R:R:T150	2.59	No	No	0	4	6
204	R:R:V208	R:R:Y127	2.52	No	Yes	0	4	5
205	R:R:K285	R:R:R38	2.48	No	No	0	1	4
206	R:R:F50	R:R:L54	2.44	No	No	0	5	4
207	R:R:F137	R:R:L223	2.44	Yes	Yes	0	8	4
208	R:R:L223	R:R:R226	2.43	Yes	No	0	4	4
209	R:R:I47	R:R:W51	2.35	No	No	0	5	5
210	R:R:L253	R:R:Y221	2.34	No	Yes	0	7	8
211	L:L:?1	R:R:L287	2.28	Yes	No	0	0	4
212	R:R:F41	R:R:R38	2.14	Yes	No	0	5	4
213	R:R:C299	R:R:G52	1.96	No	No	0	6	8
214	R:R:C159	R:R:G160	1.96	Yes	No	0	7	3
215	R:R:P262	R:R:T290	1.75	No	No	0	9	6
216	R:R:A292	R:R:V44	1.7	No	Yes	0	5	5
217	R:R:A308	R:R:T248	1.68	No	No	0	6	7
218	R:R:L91	R:R:P92	1.64	Yes	No	0	7	9
219	R:R:L261	R:R:P262	1.64	Yes	No	0	5	9
220	R:R:A295	R:R:I48	1.62	No	Yes	0	7	7
221	R:R:A139	R:R:M140	1.61	No	No	0	8	8
222	R:R:S89	R:R:T90	1.6	No	No	0	5	7
223	R:R:S117	R:R:T90	1.6	No	No	0	5	7
224	R:R:T71	R:R:V73	1.59	No	No	0	7	7
225	R:R:A95	R:R:L46	1.58	No	No	0	6	5
226	R:R:P66	R:R:Q65	1.58	No	No	0	5	5
227	R:R:A245	R:R:L228	1.58	No	No	0	7	8
228	R:R:A286	R:R:L266	1.58	No	No	0	5	5
229	R:R:T248	R:R:T252	1.57	No	No	0	7	7
230	R:R:I105	R:R:S102	1.55	No	No	0	4	5
231	R:R:I43	R:R:V44	1.54	No	Yes	0	4	5
232	R:R:I289	R:R:V288	1.54	No	No	0	5	5
233	R:R:H142	R:R:P143	1.53	No	No	0	6	8
234	R:R:I204	R:R:T200	1.52	No	No	0	3	3
235	R:R:I251	R:R:T247	1.52	No	No	0	5	6
236	R:R:N74	R:R:S70	1.49	No	No	0	7	6
237	R:R:I157	R:R:I161	1.47	No	No	0	3	3
238	R:R:I225	R:R:I250	1.47	No	No	0	5	4
239	R:R:I250	R:R:I254	1.47	No	No	0	4	4
240	R:R:L266	R:R:T265	1.47	No	No	0	5	5
241	R:R:L271	R:R:T272	1.47	No	No	0	5	4
242	R:R:A139	R:R:H148	1.46	No	No	0	8	3
243	R:R:I164	R:R:M167	1.46	No	No	0	3	3
244	R:R:F41	R:R:P42	1.44	Yes	No	0	5	5
245	R:R:K68	R:R:K69	1.44	No	No	0	6	6
246	R:R:Q65	R:R:V62	1.43	No	Yes	0	5	7
247	R:R:I219	R:R:L223	1.43	No	Yes	0	3	4
248	R:R:I224	R:R:L228	1.43	No	No	0	8	8
249	R:R:I254	R:R:L258	1.43	No	No	0	4	6
250	R:R:L198	R:R:M201	1.41	No	No	0	4	5
251	R:R:K275	R:R:L271	1.41	No	No	0	1	5
252	R:R:A308	R:R:F307	1.39	No	No	0	6	7
253	R:R:L222	R:R:L223	1.38	No	Yes	0	3	4
254	R:R:D281	R:R:N35	1.35	No	No	0	2	5
255	R:R:F214	R:R:S218	1.32	Yes	No	0	6	4
256	R:R:F40	R:R:V44	1.31	No	Yes	0	5	5
257	R:R:R239	R:R:V240	1.31	No	No	0	3	4
258	R:R:H242	R:R:L228	1.29	No	No	0	7	8
259	R:R:H242	R:R:L238	1.29	No	No	0	7	2
260	R:R:T272	R:R:Y203	1.25	No	No	0	4	4
261	R:R:F49	R:R:L46	1.22	No	No	0	6	5
262	R:R:L99	R:R:R100	1.21	No	No	0	4	4
263	R:R:F106	R:R:N103	1.21	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.15	16	1	0
2	R:R:F41	7.29	5	1	5
3	R:R:V44	1.905	4	0	5
4	R:R:I48	2.8025	4	0	7
5	R:R:I60	2.9725	4	0	7
6	R:R:V62	3.62	4	0	7
7	R:R:F63	6.074	5	0	6
8	R:R:F76	4.5875	4	5	7
9	R:R:D84	5.225	6	4	9
10	R:R:F87	5.495	4	0	6
11	R:R:L91	5.8175	4	0	7
12	R:R:Y98	10.09	4	1	5
13	R:R:W104	5.91667	6	0	8
14	R:R:Y116	9.022	5	0	5
15	R:R:Y123	6.27833	6	1	7
16	R:R:Y127	4.5725	4	1	5
17	R:R:F128	8.45833	6	2	8
18	R:R:F137	5.386	5	8	8
19	R:R:V141	5.915	4	8	7
20	R:R:W156	8.425	4	2	4
21	R:R:C159	5.5975	4	2	7
22	R:R:N202	8.96	4	1	5
23	R:R:P213	3.585	4	0	9
24	R:R:F214	5.156	5	9	6
25	R:R:Y221	6.73143	7	7	8
26	R:R:L223	1.92	4	0	4
27	R:R:L261	4.95	4	9	5
28	R:R:Y263	7.806	5	1	7
29	R:R:H264	8.25	4	1	8
30	R:R:R267	8.5	5	1	5
31	R:R:W274	18.85	5	3	3
32	R:R:H284	8.698	5	3	4
33	R:R:Y305	7.118	5	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L287	37.7894	2.28	Yes	No	0	0	4
2	R:R:H270	R:R:L287	35.9473	7.71	No	No	0	4	4
3	R:R:H270	R:R:H284	15.8821	13.14	No	Yes	3	4	4
4	L:L:?1	R:R:Y98	29.6405	8.69	Yes	Yes	1	0	5
5	L:L:?1	R:R:F41	29.4167	5.02	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y123	38.4227	7.72	Yes	Yes	1	0	7
7	R:R:H264	R:R:Y123	46.8978	10.89	Yes	Yes	1	8	7
8	R:R:C210	R:R:H264	100	8.85	No	Yes	0	8	8
9	R:R:C210	R:R:L261	99.693	4.76	No	Yes	0	8	5
10	R:R:F214	R:R:L261	97.4671	7.31	Yes	Yes	9	6	5
11	R:R:F214	R:R:F256	97.4479	6.43	Yes	No	0	6	9
12	R:R:F256	R:R:L129	47.7101	4.87	No	No	0	9	8
13	R:R:L129	R:R:Y305	82.2758	10.55	No	Yes	0	8	9
14	R:R:T252	R:R:Y305	62.8758	4.99	No	Yes	0	7	9
15	R:R:L304	R:R:T252	49.4883	4.42	No	No	0	7	7
16	R:R:I255	R:R:L304	47.1472	8.56	No	No	0	6	7
17	R:R:F300	R:R:I255	40.009	3.77	No	No	0	7	6
18	R:R:A296	R:R:F300	37.6039	4.16	No	No	0	5	7
19	R:R:A296	R:R:I48	35.1861	3.25	No	Yes	0	5	7
20	R:R:I48	R:R:V44	12.8502	3.07	Yes	Yes	0	7	5
21	L:L:?1	R:R:R267	34.4889	8	Yes	Yes	1	0	5
22	R:R:H264	R:R:R267	39.3309	5.64	Yes	Yes	1	8	5
23	L:L:?1	R:R:Y127	59.3066	6.76	Yes	Yes	1	0	5
24	R:R:P213	R:R:Y127	60.8801	4.17	Yes	Yes	0	9	5
25	R:R:I126	R:R:P213	61.6989	3.39	No	Yes	0	7	9
26	R:R:F260	R:R:I126	61.9483	8.79	No	No	0	9	7
27	R:R:F260	R:R:N297	61.5453	10.87	No	No	6	9	9
28	R:R:N297	R:R:N301	62.7862	14.98	No	No	0	9	9
29	R:R:L129	R:R:N301	58.9676	4.12	No	No	0	8	9
30	R:R:F41	R:R:P42	13.848	1.44	Yes	No	0	5	5
31	R:R:L99	R:R:P42	11.5709	3.28	No	No	0	4	5
32	R:R:C299	R:R:I48	17.9033	3.27	No	Yes	0	6	7
33	R:R:L91	R:R:P92	10.7394	1.64	Yes	No	0	7	9
34	R:R:C299	R:R:W51	12.8502	2.61	No	No	0	6	5
35	R:R:D84	R:R:N301	86.6701	4.04	Yes	No	0	9	9
36	R:R:D84	R:R:P302	50.5629	3.22	Yes	No	4	9	9
37	R:R:P302	R:R:Y306	49.4819	6.95	No	No	0	9	6
38	R:R:S59	R:R:Y306	25.4126	11.45	No	No	0	9	6
39	R:R:F63	R:R:S59	15.3959	6.61	Yes	No	0	6	9
40	R:R:F312	R:R:Y306	23.4105	21.66	No	No	0	8	6
41	R:R:F63	R:R:N74	21.2869	6.04	Yes	No	0	6	7
42	R:R:N74	R:R:R315	15.5047	4.82	No	No	0	7	4
43	R:R:R315	R:R:Y67	12.4344	14.4	No	No	0	4	5
44	R:R:F312	R:R:F63	14.9674	5.36	No	Yes	0	8	6
45	R:R:D84	R:R:S125	46.2646	4.42	Yes	No	0	9	9
46	R:R:S125	R:R:S83	44.9469	3.26	No	No	0	9	8
47	R:R:F128	R:R:S83	43.6165	3.96	Yes	No	0	8	8
48	R:R:F128	R:R:N79	18.2103	14.5	Yes	No	2	8	9
49	R:R:N79	R:R:W156	16.7328	6.78	No	Yes	2	9	4
50	R:R:C159	R:R:F128	19.9501	4.19	Yes	Yes	2	7	8
51	R:R:C159	R:R:W156	16.995	5.22	Yes	Yes	2	7	4
52	R:R:V75	R:R:W156	21.6451	13.48	No	Yes	0	6	4
53	R:R:F76	R:R:V75	15.4279	5.24	Yes	No	0	7	6
54	L:L:?1	R:R:Y119	15.4407	25.1	Yes	No	0	0	5
55	R:R:L118	R:R:Y119	13.3235	8.21	No	No	0	6	5
56	R:R:M122	R:R:Y123	15.8821	5.99	No	Yes	0	7	7
57	R:R:F87	R:R:M122	25.1439	4.98	Yes	No	0	6	7
58	R:R:L118	R:R:R94	12.6775	19.44	No	No	0	6	6
59	R:R:R94	R:R:T90	13.6114	9.06	No	No	0	6	7
60	R:R:Y97	R:R:Y98	25.4254	7.94	No	Yes	0	5	5
61	R:R:W104	R:R:Y97	23.1483	4.82	Yes	No	0	8	5
62	L:L:?1	R:R:L173	17.9481	3.42	Yes	No	0	0	5
63	R:R:L173	R:R:Y116	13.7137	7.03	No	Yes	0	5	5
64	R:R:F256	R:R:L217	50.4477	7.31	No	No	0	9	7
65	R:R:L217	R:R:Y221	49.0917	4.69	No	Yes	0	7	8
66	R:R:S133	R:R:Y221	11.9227	13.99	No	Yes	0	9	8
67	R:R:C220	R:R:S133	10.0102	5.16	No	No	0	6	9
68	R:R:I224	R:R:Y221	47.7933	3.63	No	Yes	0	8	8
69	R:R:F137	R:R:I224	37.0027	5.02	Yes	No	0	8	8
70	R:R:F137	R:R:V141	21.0375	10.49	Yes	Yes	8	8	7
71	R:R:M140	R:R:V141	17.027	3.04	No	Yes	0	8	7
72	R:R:A139	R:R:M140	14.9098	1.61	No	No	0	8	8
73	R:R:A139	R:R:H148	12.7798	1.46	No	No	0	8	3
74	R:R:H148	R:R:V149	10.8993	5.54	No	No	0	3	4
75	L:L:?1	R:R:N202	10.7394	5.65	Yes	Yes	1	0	5
76	R:R:L271	R:R:N202	12.8246	5.49	No	Yes	0	5	5
77	R:R:I249	R:R:Y221	14.8906	7.25	No	Yes	0	7	8
78	R:R:I225	R:R:I249	13.0229	4.42	No	No	0	5	7
79	R:R:I224	R:R:L228	10.3812	1.43	No	No	0	8	8
80	R:R:T248	R:R:T252	12.556	1.57	No	No	0	7	7
81	R:R:A308	R:R:T248	10.0038	1.68	No	No	0	6	7
82	R:R:H270	R:R:W274	18.1527	15.87	No	Yes	3	4	3
83	R:R:T273	R:R:W274	11.6221	20.62	No	Yes	0	3	3
84	R:R:F87	R:R:L91	11.6221	7.31	Yes	Yes	0	6	7
85	R:R:M122	R:R:Y263	12.2745	4.79	No	Yes	0	7	7
86	R:R:H264	R:R:Y263	14.0975	7.62	Yes	Yes	1	8	7
87	R:R:Y221	R:R:Y305	27.3954	5.96	Yes	Yes	7	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F41	5.02	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y98	8.69	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y119	25.1	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y123	7.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y127	6.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L165	7.98	1	Yes	No	0	4	0	1
L:L:?1	R:R:I166	8.23	1	Yes	No	0	7	0	1
L:L:?1	R:R:S169	4.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:S170	16.08	1	Yes	No	0	7	0	1
L:L:?1	R:R:L173	3.42	1	Yes	No	0	5	0	1
L:L:?1	R:R:M201	18.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:N202	5.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:A205	6.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:R267	8	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L291	11.4	1	Yes	No	0	5	0	1
R:R:F36	R:R:Y98	12.38	0	No	Yes	6	5	2	1
R:R:F41	R:R:Y45	16.5	1	Yes	No	5	8	1	2
R:R:F41	R:R:Y98	11.35	1	Yes	Yes	5	5	1	1
R:R:Y97	R:R:Y98	7.94	0	No	Yes	5	5	2	1
R:R:L173	R:R:S115	4.5	0	No	No	5	6	1	2
R:R:L173	R:R:Y116	7.03	0	No	Yes	5	5	1	2
R:R:L118	R:R:Y119	8.21	0	No	No	6	5	2	1
R:R:M122	R:R:Y123	5.99	0	No	Yes	7	7	2	1
R:R:M122	R:R:Y263	4.79	0	No	Yes	7	7	2	2
R:R:A205	R:R:Y123	4	1	No	Yes	5	7	1	1
R:R:H264	R:R:Y123	10.89	1	Yes	Yes	8	7	2	1
R:R:R267	R:R:Y123	6.17	1	Yes	Yes	5	7	1	1
R:R:I166	R:R:Y127	4.84	1	No	Yes	7	5	1	1
R:R:P213	R:R:Y127	4.17	0	Yes	Yes	9	5	2	1
R:R:N202	R:R:R267	14.46	1	Yes	Yes	5	5	1	1
R:R:N202	R:R:T268	10.24	1	Yes	No	5	6	1	2
R:R:L271	R:R:N202	5.49	0	No	Yes	5	5	2	1
R:R:H264	R:R:Y263	7.62	1	Yes	Yes	8	7	2	2
R:R:R267	R:R:Y263	8.23	1	Yes	Yes	5	7	1	2
R:R:L291	R:R:Y263	11.72	0	No	Yes	5	7	1	2
R:R:H264	R:R:R267	5.64	1	Yes	Yes	8	5	2	1
R:R:H270	R:R:L287	7.71	3	No	No	4	4	2	1
R:R:G209	R:R:Y123	2.9	0	No	Yes	5	7	2	1
R:R:V208	R:R:Y127	2.52	0	No	Yes	4	5	2	1
L:L:?1	R:R:L287	2.28	1	Yes	No	0	4	0	1
R:R:F41	R:R:R38	2.14	1	Yes	No	5	4	1	2
R:R:F41	R:R:P42	1.44	1	Yes	No	5	5	1	2
R:R:L198	R:R:M201	1.41	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JH6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	242
Number of Links	263
Number of Hubs	33
Number of Links mediated by Hubs	142
Number of Communities	9
Number of Nodes involved in Communities	39
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	41559
Length Of Smallest Path	3
Average Path Length	13.7783
Length of Longest Path	27
Minimum Path Strength	1.29
Average Path Strength	6.4792
Maximum Path Strength	23.06
Minimum Path Correlation	0.7
Average Path Correlation	0.913566
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	43.0053
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.5069
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NS75
Sequence	>9JH6_nogp_Chain_R E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P Y K K S T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G S N W I F G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H P F R L L H V T S I R S A W I L C G I I W I L I M A S S I M L L D K I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K V G L C K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N F K D R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6RZ6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ7	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ8	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2080365	-	-	2.7	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ9	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2770372	-	-	2.73	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	9IXX	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9IXX (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-		3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9JH5	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH5 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-		2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-		2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JH6_nogp.zip

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