psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y116	5.15	Yes	No	0	0	5
2	L:L:?1	R:R:Y123	23.68	Yes	No	1	0	7
3	L:L:?1	R:R:Y127	10.3	Yes	Yes	1	0	5
4	L:L:?1	R:R:I166	11.28	Yes	No	0	0	7
5	L:L:?1	R:R:S170	7.91	Yes	No	0	0	7
6	L:L:?1	R:R:I195	21.31	Yes	No	0	0	2
7	L:L:?1	R:R:L198	3.65	Yes	No	0	0	4
8	L:L:?1	R:R:N202	28.94	Yes	Yes	1	0	5
9	L:L:?1	R:R:R267	25.61	Yes	Yes	1	0	5
10	L:L:?1	R:R:H270	15.81	Yes	No	0	0	4
11	L:L:?1	R:R:L271	17.02	Yes	Yes	1	0	5
12	L:L:?1	R:R:K275	11.15	Yes	No	0	0	1
13	R:R:N35	R:R:W274	4.52	No	Yes	3	5	3
14	R:R:C279	R:R:N35	6.3	No	No	3	1	5
15	R:R:H284	R:R:N35	12.75	Yes	No	3	4	5
16	R:R:F40	R:R:R38	16.03	No	No	0	5	4
17	R:R:K285	R:R:R38	7.43	No	No	0	1	4
18	R:R:E39	R:R:Y98	14.59	No	No	0	4	5
19	R:R:P42	R:R:Y45	4.17	No	Yes	0	5	8
20	R:R:A95	R:R:Y45	4	No	Yes	0	6	8
21	R:R:Y45	R:R:Y98	7.94	Yes	No	0	8	5
22	R:R:L291	R:R:Y45	3.52	No	Yes	0	5	8
23	R:R:F50	R:R:L46	12.18	No	No	0	5	5
24	R:R:A295	R:R:I48	4.87	No	Yes	0	7	7
25	R:R:F49	R:R:F50	6.43	No	No	0	6	5
26	R:R:F49	R:R:P92	8.67	No	No	0	6	9
27	R:R:C299	R:R:W51	3.92	No	No	0	6	5
28	R:R:G55	R:R:P302	4.06	No	No	0	7	9
29	R:R:I60	R:R:N56	4.25	No	Yes	0	7	9
30	R:R:A81	R:R:N56	4.69	No	Yes	0	8	9
31	R:R:D84	R:R:N56	5.39	No	Yes	0	9	9
32	R:R:L85	R:R:N56	4.12	No	Yes	0	7	9
33	R:R:G57	R:R:I60	3.53	No	No	0	3	7
34	R:R:L316	R:R:L58	6.92	No	No	0	5	5
35	R:R:F63	R:R:S59	3.96	Yes	No	2	6	9
36	R:R:S59	R:R:Y306	10.17	No	Yes	2	9	6
37	R:R:F312	R:R:S59	5.28	Yes	No	2	8	9
38	R:R:F312	R:R:V62	5.24	Yes	No	0	8	7
39	R:R:L316	R:R:V62	4.47	No	No	0	5	7
40	R:R:F63	R:R:N74	6.04	Yes	Yes	2	6	7
41	R:R:F63	R:R:M77	8.71	Yes	No	0	6	8
42	R:R:F312	R:R:F63	7.5	Yes	Yes	2	8	6
43	R:R:Q65	R:R:Y67	7.89	No	No	0	5	5
44	R:R:R315	R:R:Y67	10.29	Yes	No	0	4	5
45	R:R:K69	R:R:N74	12.59	No	Yes	2	6	7
46	R:R:K69	R:R:S151	6.12	No	No	0	6	6
47	R:R:K69	R:R:R315	3.71	No	Yes	2	6	4
48	R:R:N311	R:R:S70	8.94	No	No	0	6	6
49	R:R:S72	R:R:T71	3.2	No	No	0	6	7
50	R:R:T71	R:R:V73	3.17	No	No	0	7	7
51	R:R:A155	R:R:S72	3.42	No	No	0	7	6
52	R:R:N74	R:R:V73	4.43	Yes	No	0	7	7
53	R:R:N74	R:R:R315	8.44	Yes	Yes	2	7	4
54	R:R:A155	R:R:V75	5.09	No	No	0	7	6
55	R:R:V75	R:R:W156	15.94	No	Yes	0	6	4
56	R:R:F76	R:R:V131	3.93	No	No	0	7	6
57	R:R:F76	R:R:V135	3.93	No	No	0	7	8
58	R:R:F76	R:R:L158	3.65	No	No	0	7	5
59	R:R:L132	R:R:M77	4.24	No	No	0	9	8
60	R:R:M77	R:R:Y306	4.79	No	Yes	0	8	6
61	R:R:L78	R:R:W156	3.42	No	Yes	0	5	4
62	R:R:F128	R:R:N79	14.5	Yes	No	0	8	9
63	R:R:N79	R:R:W156	4.52	No	Yes	4	9	4
64	R:R:C159	R:R:N79	11.02	No	No	4	7	9
65	R:R:F128	R:R:L80	3.65	Yes	No	0	8	9
66	R:R:L80	R:R:N301	5.49	No	No	0	9	9
67	R:R:I82	R:R:W163	4.7	No	No	0	5	9
68	R:R:N121	R:R:S83	5.96	No	No	0	8	8
69	R:R:S125	R:R:S83	4.89	No	No	0	9	8
70	R:R:A298	R:R:D84	4.63	No	No	0	8	9
71	R:R:D84	R:R:N301	4.04	No	No	0	9	9
72	R:R:L86	R:R:N121	5.49	No	No	0	6	8
73	R:R:F87	R:R:N121	3.62	No	No	0	6	8
74	R:R:I88	R:R:L91	5.71	No	No	0	6	7
75	R:R:R94	R:R:T90	9.06	No	No	0	6	7
76	R:R:L118	R:R:T90	4.42	No	No	0	6	7
77	R:R:L91	R:R:P92	4.93	No	No	0	7	9
78	R:R:M114	R:R:R94	4.96	No	No	0	5	6
79	R:R:R94	R:R:Y119	14.4	No	No	0	6	5
80	R:R:D96	R:R:R100	4.76	No	No	5	3	4
81	R:R:D96	R:R:N103	13.46	No	No	5	3	4
82	R:R:W104	R:R:Y97	4.82	Yes	No	0	8	5
83	R:R:N103	R:R:R100	12.05	No	No	5	4	4
84	R:R:D108	R:R:W104	3.35	No	Yes	0	4	8
85	R:R:C111	R:R:W104	13.06	No	Yes	0	9	8
86	R:R:M114	R:R:W104	3.49	No	Yes	0	5	8
87	R:R:F106	R:R:G107	4.52	No	No	0	5	7
88	R:R:D108	R:R:G107	3.35	No	No	0	4	7
89	R:R:A110	R:R:D108	4.63	No	No	0	5	4
90	R:R:L109	R:R:R112	8.5	No	No	0	3	7
91	R:R:S115	R:R:Y193	10.17	No	Yes	0	6	3
92	R:R:L173	R:R:Y116	3.52	No	No	0	5	5
93	R:R:L174	R:R:Y116	7.03	No	No	0	5	5
94	R:R:L174	R:R:S117	4.5	No	No	0	5	5
95	R:R:M167	R:R:V120	4.56	No	No	0	3	5
96	R:R:S170	R:R:V120	4.85	No	No	0	7	5
97	R:R:M122	R:R:Y123	3.59	No	No	0	7	7
98	R:R:M122	R:R:Y263	4.79	No	Yes	0	7	7
99	R:R:R267	R:R:Y123	4.12	Yes	No	1	5	7
100	R:R:F128	R:R:S124	5.28	Yes	No	0	8	7
101	R:R:I126	R:R:Y127	3.63	No	Yes	1	7	5
102	R:R:I126	R:R:P213	3.39	No	Yes	1	7	9
103	R:R:F260	R:R:I126	11.3	Yes	No	0	9	7
104	R:R:G209	R:R:Y127	4.35	No	Yes	0	5	5
105	R:R:P213	R:R:Y127	5.56	Yes	Yes	1	9	5
106	R:R:F128	R:R:I162	6.28	Yes	No	0	8	6
107	R:R:F128	R:R:W163	11.02	Yes	No	0	8	9
108	R:R:L129	R:R:Y305	4.69	No	Yes	0	8	9
109	R:R:S133	R:R:T130	3.2	No	No	0	9	7
110	R:R:P213	R:R:T130	5.25	Yes	No	0	9	7
111	R:R:L132	R:R:Y305	5.86	No	Yes	0	9	9
112	R:R:L217	R:R:S133	7.51	No	No	6	7	9
113	R:R:S133	R:R:Y221	6.36	No	Yes	6	9	8
114	R:R:C220	R:R:V134	3.42	No	No	0	6	5
115	R:R:R136	R:R:Y221	6.17	No	Yes	0	9	8
116	R:R:R136	R:R:Y305	9.26	No	Yes	0	9	9
117	R:R:F137	R:R:L138	3.65	Yes	No	0	8	5
118	R:R:F137	R:R:V141	10.49	Yes	No	0	8	7
119	R:R:C220	R:R:F137	6.98	No	Yes	0	6	8
120	R:R:F137	R:R:L223	7.31	Yes	No	0	8	4
121	R:R:F137	R:R:I224	3.77	Yes	Yes	0	8	8
122	R:R:A139	R:R:M140	3.22	No	No	0	8	8
123	R:R:A139	R:R:H148	4.39	No	No	0	8	3
124	R:R:I224	R:R:M140	4.37	Yes	No	0	8	8
125	R:R:V141	R:R:V227	4.81	No	No	0	7	5
126	R:R:T150	R:R:V149	9.52	No	No	0	6	4
127	R:R:S154	R:R:T150	9.59	No	No	0	4	6
128	R:R:I152	R:R:R153	12.53	No	No	0	3	4
129	R:R:I157	R:R:R153	5.01	No	No	0	3	4
130	R:R:C159	R:R:W156	7.84	No	Yes	4	7	4
131	R:R:L173	R:R:M201	4.24	No	No	0	5	5
132	R:R:D175	R:R:Y193	4.6	No	Yes	0	5	3
133	R:R:A196	R:R:D175	4.63	No	No	0	1	5
134	R:R:K194	R:R:Y193	3.58	No	Yes	0	3	3
135	R:R:K197	R:R:Q199	6.78	No	Yes	0	3	3
136	R:R:Q199	R:R:Y203	12.4	Yes	No	1	3	4
137	R:R:L271	R:R:Q199	3.99	Yes	Yes	1	5	3
138	R:R:N202	R:R:R267	13.26	Yes	Yes	1	5	5
139	R:R:N202	R:R:T268	4.39	Yes	No	0	5	6
140	R:R:L271	R:R:N202	13.73	Yes	Yes	1	5	5
141	R:R:L271	R:R:Y203	22.27	Yes	No	1	5	4
142	R:R:T272	R:R:Y203	4.99	No	No	0	4	4
143	R:R:C210	R:R:L206	9.52	No	Yes	1	8	5
144	R:R:L206	R:R:L211	5.54	Yes	No	0	5	4
145	R:R:H264	R:R:L206	3.86	Yes	Yes	1	8	5
146	R:R:L206	R:R:T268	5.9	Yes	No	0	5	6
147	R:R:G209	R:R:V208	3.68	No	No	0	5	4
148	R:R:C210	R:R:H264	11.79	No	Yes	1	8	8
149	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
150	R:R:F214	R:R:F256	4.29	Yes	No	0	6	9
151	R:R:F214	R:R:F257	6.43	Yes	No	0	6	5
152	R:R:F214	R:R:L261	6.09	Yes	No	0	6	5
153	R:R:L217	R:R:Y221	5.86	No	Yes	6	7	8
154	R:R:F256	R:R:L217	3.65	No	No	0	9	7
155	R:R:I249	R:R:Y221	3.63	No	Yes	0	7	8
156	R:R:T252	R:R:Y221	3.75	No	Yes	0	7	8
157	R:R:I225	R:R:L246	4.28	No	No	0	5	5
158	R:R:H242	R:R:L228	9	No	No	0	7	8
159	R:R:R239	R:R:R243	9.6	No	No	0	3	5
160	R:R:H242	R:R:S241	6.97	No	No	0	7	5
161	R:R:T252	R:R:Y305	4.99	No	Yes	0	7	9
162	R:R:I255	R:R:L304	7.14	No	No	0	6	7
163	R:R:F256	R:R:F260	7.5	No	Yes	0	9	9
164	R:R:L258	R:R:L293	4.15	No	Yes	0	6	7
165	R:R:C259	R:R:F260	4.19	No	Yes	0	8	9
166	R:R:C259	R:R:L293	3.17	No	Yes	0	8	7
167	R:R:F260	R:R:N297	3.62	Yes	No	0	9	9
168	R:R:P262	R:R:T290	3.5	No	No	0	9	6
169	R:R:H264	R:R:Y263	3.27	Yes	Yes	1	8	7
170	R:R:R267	R:R:Y263	4.12	Yes	Yes	1	5	7
171	R:R:T290	R:R:Y263	14.98	No	Yes	0	6	7
172	R:R:L291	R:R:Y263	3.52	No	Yes	0	5	7
173	R:R:A294	R:R:Y263	4	No	Yes	0	8	7
174	R:R:H264	R:R:R267	3.39	Yes	Yes	1	8	5
175	R:R:T273	R:R:V269	3.17	No	No	0	3	5
176	R:R:H270	R:R:W274	25.39	No	Yes	0	4	3
177	R:R:T272	R:R:T273	6.28	No	No	0	4	3
178	R:R:T273	R:R:W274	7.28	No	Yes	0	3	3
179	R:R:C279	R:R:W274	11.75	No	Yes	3	1	3
180	R:R:L283	R:R:W274	11.39	No	Yes	0	4	3
181	R:R:H284	R:R:W274	3.17	Yes	Yes	3	4	3
182	R:R:D281	R:R:K280	8.3	No	No	0	2	3
183	R:R:K280	R:R:R282	16.09	No	No	0	3	3
184	R:R:K280	R:R:L283	4.23	No	No	0	3	4
185	R:R:D281	R:R:K285	8.3	No	No	0	2	1
186	R:R:H284	R:R:L287	10.29	Yes	No	0	4	4
187	R:R:L291	R:R:V288	10.43	No	No	0	5	5
188	R:R:N297	R:R:N301	10.9	No	No	0	9	9
189	R:R:F300	R:R:L303	3.65	No	No	0	7	6
190	R:R:L303	R:R:L304	4.15	No	No	0	6	7
191	R:R:F312	R:R:Y306	18.57	Yes	Yes	2	8	6
192	R:R:F307	R:R:K313	6.2	No	No	0	7	8
193	R:R:F312	R:R:K313	4.96	Yes	No	0	8	8
194	R:R:P66	R:R:Q65	3.16	No	No	0	5	5
195	R:R:A196	R:R:L198	3.15	No	No	0	1	4
196	R:R:A245	R:R:L228	3.15	No	No	0	7	8
197	R:R:A296	R:R:L293	3.15	No	Yes	0	5	7
198	R:R:T130	R:R:T216	3.14	No	No	0	7	6
199	R:R:T265	R:R:T268	3.14	No	No	0	5	6
200	R:R:I105	R:R:S102	3.1	No	No	0	4	5
201	R:R:I219	R:R:S218	3.1	No	No	0	3	4
202	R:R:R112	R:R:Y193	3.09	No	Yes	0	7	3
203	R:R:M114	R:R:S115	3.07	No	No	0	5	6
204	R:R:L86	R:R:S89	3	No	No	0	6	5
205	R:R:L146	R:R:V149	2.98	No	No	0	6	4
206	R:R:I43	R:R:I47	2.94	No	No	0	4	5
207	R:R:I224	R:R:I249	2.94	Yes	No	0	8	7
208	R:R:I225	R:R:I249	2.94	No	No	0	5	7
209	R:R:I250	R:R:I254	2.94	No	No	0	4	4
210	R:R:I251	R:R:I255	2.94	No	No	0	5	6
211	R:R:F144	R:R:P143	2.89	No	No	0	5	8
212	R:R:I171	R:R:L174	2.85	No	No	0	4	5
213	R:R:I219	R:R:L223	2.85	No	No	0	3	4
214	R:R:I224	R:R:L228	2.85	Yes	No	0	8	8
215	R:R:I250	R:R:L246	2.85	No	No	0	4	5
216	R:R:I289	R:R:L293	2.85	No	Yes	0	5	7
217	R:R:P302	R:R:Y306	2.78	No	Yes	0	9	6
218	R:R:H142	R:R:V141	2.77	No	No	0	6	7
219	R:R:L229	R:R:L246	2.77	No	No	0	4	5
220	R:R:A296	R:R:F300	2.77	No	No	0	5	7
221	R:R:N311	R:R:N74	2.72	No	Yes	0	6	7
222	L:L:?1	R:R:S169	2.64	Yes	No	0	0	5
223	R:R:R153	R:R:S154	2.64	No	No	0	4	4
224	R:R:H242	R:R:L238	2.57	No	No	0	7	2
225	R:R:F87	R:R:M122	2.49	No	No	0	6	7
226	L:L:?1	R:R:L165	2.43	Yes	No	0	0	4
227	R:R:L99	R:R:R100	2.43	No	No	0	4	4
228	R:R:L147	R:R:R145	2.43	No	No	0	5	5
229	R:R:L64	R:R:Y61	2.34	No	No	0	3	4
230	R:R:L253	R:R:Y221	2.34	No	Yes	0	7	8
231	R:R:F36	R:R:H284	2.26	No	Yes	0	6	4
232	R:R:F214	R:R:F215	2.14	Yes	No	0	6	3
233	R:R:F93	R:R:W104	2	No	Yes	0	6	8
234	R:R:C159	R:R:G160	1.96	No	No	0	7	3
235	R:R:G237	R:R:S241	1.86	No	No	0	4	5
236	R:R:G160	R:R:I164	1.76	No	No	0	3	3
237	R:R:A292	R:R:V44	1.7	No	No	0	5	5
238	R:R:I43	R:R:P42	1.69	No	No	0	4	5
239	R:R:A308	R:R:T248	1.68	No	No	0	6	7
240	R:R:C299	R:R:I48	1.64	No	Yes	0	6	7
241	R:R:A296	R:R:I48	1.62	No	Yes	0	5	7
242	R:R:A298	R:R:I88	1.62	No	No	0	8	6
243	R:R:A110	R:R:I113	1.62	No	No	0	5	5
244	R:R:S72	R:R:T150	1.6	No	No	0	6	6
245	R:R:V135	R:R:V73	1.6	No	No	0	8	7
246	R:R:A286	R:R:L266	1.58	No	No	0	5	5
247	R:R:T248	R:R:T252	1.57	No	No	0	7	7
248	R:R:I48	R:R:V44	1.54	Yes	No	0	7	5
249	R:R:H142	R:R:P143	1.53	No	No	0	6	8
250	R:R:I204	R:R:T200	1.52	No	No	0	3	3
251	R:R:I251	R:R:T247	1.52	No	No	0	5	6
252	R:R:L54	R:R:V53	1.49	No	No	0	4	6
253	R:R:I157	R:R:I161	1.47	No	No	0	3	3
254	R:R:L266	R:R:T265	1.47	No	No	0	5	5
255	R:R:I225	R:R:L222	1.43	No	No	0	5	3
256	R:R:Q199	R:R:T200	1.42	Yes	No	0	3	3
257	R:R:L173	R:R:M172	1.41	No	No	0	5	8
258	L:L:?1	R:R:A205	1.38	Yes	No	0	0	5
259	R:R:L138	R:R:L147	1.38	No	No	0	5	5
260	R:R:E34	R:R:K275	1.35	No	No	0	4	1
261	R:R:R239	R:R:V240	1.31	No	No	0	3	4
262	R:R:D314	R:R:R315	1.19	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.5507	15	1	0
2	R:R:Y45	4.9075	4	0	8
3	R:R:I48	2.4175	4	0	7
4	R:R:N56	4.6125	4	0	9
5	R:R:F63	6.5525	4	2	6
6	R:R:N74	6.844	5	2	7
7	R:R:W104	5.344	5	0	8
8	R:R:Y127	5.96	4	1	5
9	R:R:F128	8.146	5	0	8
10	R:R:F137	6.44	5	0	8
11	R:R:W156	7.93	4	4	4
12	R:R:Y193	5.36	4	0	3
13	R:R:Q199	6.1475	4	1	3
14	R:R:N202	15.08	4	1	5
15	R:R:L206	6.205	4	1	5
16	R:R:P213	4.37	4	1	9
17	R:R:F214	4.7375	4	0	6
18	R:R:Y221	4.685	6	6	8
19	R:R:I224	3.4825	4	0	8
20	R:R:F260	6.6525	4	0	9
21	R:R:Y263	5.78	6	1	7
22	R:R:H264	5.5775	4	1	8
23	R:R:R267	10.1	5	1	5
24	R:R:L271	14.2525	4	1	5
25	R:R:W274	10.5833	6	3	3
26	R:R:H284	7.1175	4	3	4
27	R:R:L293	3.33	4	0	7
28	R:R:Y305	6.2	4	0	9
29	R:R:Y306	9.0775	4	2	6
30	R:R:F312	8.31	5	2	8
31	R:R:R315	5.9075	4	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H270	23.4497	15.81	Yes	No	0	0	4
2	R:R:H270	R:R:W274	22.2629	25.39	No	Yes	0	4	3
3	R:R:L283	R:R:W274	11.0704	11.39	No	Yes	0	4	3
4	L:L:?1	R:R:R267	24.9506	25.61	Yes	Yes	1	0	5
5	R:R:R267	R:R:Y263	19.3077	4.12	Yes	Yes	1	5	7
6	R:R:L291	R:R:Y263	13.9616	3.52	No	Yes	0	5	7
7	R:R:L291	R:R:Y45	11.018	3.52	No	Yes	0	5	8
8	L:L:?1	R:R:Y127	100	10.3	Yes	Yes	1	0	5
9	R:R:I126	R:R:Y127	36.3176	3.63	No	Yes	1	7	5
10	R:R:F260	R:R:I126	38.0105	11.3	Yes	No	0	9	7
11	R:R:F260	R:R:N297	38.8133	3.62	Yes	No	0	9	9
12	R:R:N297	R:R:N301	37.7254	10.9	No	No	0	9	9
13	R:R:D84	R:R:N301	18.9761	4.04	No	No	0	9	9
14	R:R:A298	R:R:D84	10.4596	4.63	No	No	0	8	9
15	R:R:C259	R:R:F260	25.9046	4.19	No	Yes	0	8	9
16	R:R:C259	R:R:L293	24.4735	3.17	No	Yes	0	8	7
17	R:R:A296	R:R:L293	20.1105	3.15	No	Yes	0	5	7
18	R:R:P213	R:R:Y127	65.4508	5.56	Yes	Yes	1	9	5
19	R:R:P213	R:R:T130	66.8703	5.25	Yes	No	0	9	7
20	R:R:S133	R:R:T130	66.7423	3.2	No	No	0	9	7
21	R:R:S133	R:R:Y221	66.2536	6.36	No	Yes	6	9	8
22	R:R:R136	R:R:Y221	39.9186	6.17	No	Yes	0	9	8
23	R:R:R136	R:R:Y305	39.2088	9.26	No	Yes	0	9	9
24	R:R:L132	R:R:Y305	75.3985	5.86	No	Yes	0	9	9
25	R:R:L132	R:R:M77	73.5486	4.24	No	No	0	9	8
26	R:R:M77	R:R:Y306	21.5009	4.79	No	Yes	0	8	6
27	R:R:T252	R:R:Y221	41.9255	3.75	No	Yes	0	7	8
28	R:R:T252	R:R:Y305	39.6626	4.99	No	Yes	0	7	9
29	R:R:F63	R:R:M77	51.8674	8.71	Yes	No	0	6	8
30	R:R:F312	R:R:F63	14.3921	7.5	Yes	Yes	2	8	6
31	R:R:F312	R:R:V62	13.5195	5.24	Yes	No	0	8	7
32	R:R:F312	R:R:Y306	13.4846	18.57	Yes	Yes	2	8	6
33	R:R:F63	R:R:N74	38.6446	6.04	Yes	Yes	2	6	7
34	R:R:N74	R:R:R315	11.5358	8.44	Yes	Yes	2	7	4
35	R:R:L80	R:R:N301	23.7173	5.49	No	No	0	9	9
36	R:R:F128	R:R:L80	22.8505	3.65	Yes	No	0	8	9
37	R:R:F128	R:R:N79	19.0401	14.5	Yes	No	0	8	9
38	R:R:N79	R:R:W156	14.8691	4.52	No	Yes	4	9	4
39	R:R:V75	R:R:W156	14.2583	15.94	No	Yes	0	6	4
40	R:R:A155	R:R:V75	13.4555	5.09	No	No	0	7	6
41	R:R:A155	R:R:S72	13.2286	3.42	No	No	0	7	6
42	R:R:S72	R:R:T71	11.2042	3.2	No	No	0	6	7
43	R:R:N74	R:R:V73	20.9308	4.43	Yes	No	0	7	7
44	R:R:T71	R:R:V73	12.1931	3.17	No	No	0	7	7
45	L:L:?1	R:R:Y123	11.6987	23.68	Yes	No	1	0	7
46	R:R:M122	R:R:Y123	10.6981	3.59	No	No	0	7	7
47	R:R:F87	R:R:M122	10.0814	2.49	No	No	0	6	7
48	L:L:?1	R:R:L198	31.7045	3.65	Yes	No	0	0	4
49	R:R:A196	R:R:L198	30.5817	3.15	No	No	0	1	4
50	R:R:A196	R:R:D175	29.1507	4.63	No	No	0	1	5
51	R:R:D175	R:R:Y193	27.9988	4.6	No	Yes	0	5	3
52	R:R:S115	R:R:Y193	22.4724	10.17	No	Yes	0	6	3
53	R:R:M114	R:R:S115	21.0064	3.07	No	No	0	5	6
54	R:R:M114	R:R:W104	14.0081	3.49	No	Yes	0	5	8
55	L:L:?1	R:R:Y116	10.9075	5.15	Yes	No	0	0	5
56	R:R:I249	R:R:Y221	45.957	3.63	No	Yes	0	7	8
57	R:R:I224	R:R:I249	36.5561	2.94	Yes	No	0	8	7
58	R:R:F137	R:R:I224	22.5538	3.77	Yes	Yes	0	8	8
59	R:R:S72	R:R:T150	12.3095	1.6	No	No	0	6	6
60	L:L:?1	R:R:L271	10.349	17.02	Yes	Yes	1	0	5
61	R:R:F256	R:R:F260	28.0803	7.5	No	Yes	0	9	9
62	R:R:F256	R:R:L217	26.8063	3.65	No	No	0	9	7
63	R:R:L217	R:R:Y221	26.4689	5.86	No	Yes	6	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y116	5.15	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y123	23.68	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y127	10.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I166	11.28	1	Yes	No	0	7	0	1
L:L:?1	R:R:S170	7.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:I195	21.31	1	Yes	No	0	2	0	1
L:L:?1	R:R:L198	3.65	1	Yes	No	0	4	0	1
L:L:?1	R:R:N202	28.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R267	25.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H270	15.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:L271	17.02	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:K275	11.15	1	Yes	No	0	1	0	1
R:R:L173	R:R:Y116	3.52	0	No	No	5	5	2	1
R:R:L174	R:R:Y116	7.03	0	No	No	5	5	2	1
R:R:S170	R:R:V120	4.85	0	No	No	7	5	1	2
R:R:M122	R:R:Y123	3.59	0	No	No	7	7	2	1
R:R:M122	R:R:Y263	4.79	0	No	Yes	7	7	2	2
R:R:R267	R:R:Y123	4.12	1	Yes	No	5	7	1	1
R:R:I126	R:R:Y127	3.63	1	No	Yes	7	5	2	1
R:R:I126	R:R:P213	3.39	1	No	Yes	7	9	2	2
R:R:G209	R:R:Y127	4.35	0	No	Yes	5	5	2	1
R:R:P213	R:R:Y127	5.56	1	Yes	Yes	9	5	2	1
R:R:Q199	R:R:Y203	12.4	1	Yes	No	3	4	2	2
R:R:L271	R:R:Q199	3.99	1	Yes	Yes	5	3	1	2
R:R:N202	R:R:R267	13.26	1	Yes	Yes	5	5	1	1
R:R:N202	R:R:T268	4.39	1	Yes	No	5	6	1	2
R:R:L271	R:R:N202	13.73	1	Yes	Yes	5	5	1	1
R:R:L271	R:R:Y203	22.27	1	Yes	No	5	4	1	2
R:R:H264	R:R:Y263	3.27	1	Yes	Yes	8	7	2	2
R:R:R267	R:R:Y263	4.12	1	Yes	Yes	5	7	1	2
R:R:H264	R:R:R267	3.39	1	Yes	Yes	8	5	2	1
R:R:H270	R:R:W274	25.39	0	No	Yes	4	3	1	2
R:R:A196	R:R:L198	3.15	0	No	No	1	4	2	1
L:L:?1	R:R:S169	2.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:L165	2.43	1	Yes	No	0	4	0	1
L:L:?1	R:R:A205	1.38	1	Yes	No	0	5	0	1
R:R:E34	R:R:K275	1.35	0	No	No	4	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JH5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	246
Number of Links	262
Number of Hubs	31
Number of Links mediated by Hubs	129
Number of Communities	6
Number of Nodes involved in Communities	34
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	35102
Length Of Smallest Path	3
Average Path Length	12.8532
Length of Longest Path	28
Minimum Path Strength	1.47
Average Path Strength	6.46817
Maximum Path Strength	26.31
Minimum Path Correlation	0.7
Average Path Correlation	0.909197
Maximum Path Correlation	0.98
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	40.4808
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.3488
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	16C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	16C
Name	N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE
Synonyms	C16-CERAMIDE; N-PALMITOYL-D-ERYTHRO-SPHINGOSINE; (2S,3R,4E)-2-PALMITOYLAMINOOCTADEC-4-ENE-1,3-DIOL; (2S,3R,4E)-2-PALMITOYLAMINO-1,3-OCTADEC-4-ENEDIOL
Identifier
Formula	C34 H67 N O3
Molecular Weight	537.901
SMILES
PubChem	5283564
Formal Charge	0
Total Atoms	105
Total Chiral Atoms	2
Total Bonds	104
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NS75
Sequence	>9JH5_nogp_Chain_R E N F K R E F P I V Y L I I F F W G V L G N G L S I Y V F L Q P Y K K S T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G S N W I F G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H P F R L L H V T S I R S A W I L C G I I W I L I M A S S I M L L D Y K I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K V G L C K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N F K D R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6RZ6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ7	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2570366	-	-	2.43	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ8	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2080365	-	-	2.7	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	6RZ9	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	ONO-2770372	-	-	2.73	2019-12-11	doi.org/10.1038/s41467-019-13348-2
	9JH5	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH5 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C16:0 Ceramide	-		2.76	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9JH6 (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	C20:0 Ceramide	-		2.89	2025-04-23	doi.org/10.1038/s41586-025-08792-8
	9IXX	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.15	2025-04-02	doi.org/10.1073/pnas.2417148122
	9IXX (No Gprot)	A	Lipid	Leukotriene	CysLT₂	Homo sapiens	LTD4	-		3.15	2025-04-02	doi.org/10.1073/pnas.2417148122

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