Code16C
NameN-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE
SynonymsC16-CERAMIDE; N-PALMITOYL-D-ERYTHRO-SPHINGOSINE; (2S,3R,4E)-2-PALMITOYLAMINOOCTADEC-4-ENE-1,3-DIOL; (2S,3R,4E)-2-PALMITOYLAMINO-1,3-OCTADEC-4-ENEDIOL
Identifier
FormulaC34 H67 N O3
Molecular Weight537.901
SMILES
PubChem5283564
Formal Charge0
Total Atoms105
Total Chiral Atoms2
Total Bonds104
Total Aromatic Bonds0
Networks4
 missing image

This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y62 A Peptide Formylpeptide FPR2-ALX Homo Sapiens C16:0 Ceramide - Gi1/Beta1/Gamma2 3.2 2025-02-05 doi.org/10.1126/science.ado4188

A 2D representation of the interactions of 16C in 8Y62
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:E89 3.49 2 Yes No 0 4 0 1
L:L:?1 R:R:D106 2.38 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L109 2.43 2 Yes No 0 8 0 1
L:L:?1 R:R:F110 5.35 2 Yes Yes 0 7 0 1
L:L:?1 R:R:Y175 5.15 2 Yes Yes 0 3 0 1
L:L:?1 R:R:R190 2.13 2 Yes No 0 5 0 1
L:L:?1 R:R:R201 4.27 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R205 10.67 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F257 3.21 2 Yes Yes 0 7 0 1
R:R:E89 R:R:Y175 24.69 2 No Yes 4 3 1 1
R:R:D106 R:R:F110 8.36 2 Yes Yes 5 7 1 1
R:R:D106 R:R:T157 10.12 2 Yes No 5 7 1 2
R:R:D106 R:R:V160 4.38 2 Yes Yes 5 4 1 2
R:R:L109 R:R:W254 5.69 0 No Yes 8 9 1 2
R:R:F292 R:R:L109 3.65 0 Yes No 7 8 2 1
R:R:F110 R:R:F114 2.14 2 Yes No 7 6 1 2
R:R:F110 R:R:L156 2.44 2 Yes Yes 7 5 1 2
R:R:F110 R:R:R205 2.14 2 Yes Yes 7 5 1 1
R:R:T157 R:R:V160 4.76 2 No Yes 7 4 2 2
R:R:C176 R:R:Y175 5.38 2 Yes Yes 9 3 2 1
R:R:T177 R:R:Y175 6.24 0 No Yes 3 3 2 1
R:R:F178 R:R:F180 3.22 2 Yes Yes 4 6 2 2
R:R:F178 R:R:R201 8.55 2 Yes Yes 4 5 2 1
R:R:F180 R:R:R190 4.28 2 Yes No 6 5 2 1
R:R:G184 R:R:R190 4.5 0 No No 3 5 2 1
R:R:R201 R:R:R205 4.26 2 Yes Yes 5 5 1 1
R:R:Q258 R:R:R205 7.01 2 Yes Yes 8 5 2 1
R:R:A261 R:R:R205 4.15 0 No Yes 5 5 2 1
R:R:F257 R:R:W254 4.01 2 Yes Yes 7 9 1 2
R:R:Q258 R:R:W254 3.29 2 Yes Yes 8 9 2 2
R:R:A291 R:R:W254 2.59 2 No Yes 8 9 2 2
R:R:F257 R:R:S288 2.64 2 Yes No 7 6 1 2
R:R:A291 R:R:F257 5.55 2 No Yes 8 7 2 1
R:R:F292 R:R:S288 2.64 0 Yes No 7 6 2 2
R:R:G202 R:R:R201 1.5 2 No Yes 4 5 2 1
R:R:G202 R:R:R205 1.5 2 No Yes 4 5 2 1
L:L:?1 R:R:V284 1.31 2 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength4.04
Average Nodes In Shell27.00
Average Hubs In Shell15.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JH5 A Lipid Leukotriene CysLT2 Homo Sapiens C16:0 Ceramide - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.76 2025-04-23 doi.org/10.1038/s41586-025-08792-8

A 2D representation of the interactions of 16C in 9JH5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y116 5.15 14 Yes No 0 5 0 1
L:L:?1 R:R:Y123 23.68 14 Yes No 0 7 0 1
L:L:?1 R:R:Y127 10.3 14 Yes Yes 0 5 0 1
L:L:?1 R:R:I166 11.28 14 Yes No 0 7 0 1
L:L:?1 R:R:S170 7.91 14 Yes No 0 7 0 1
L:L:?1 R:R:I195 21.31 14 Yes No 0 2 0 1
L:L:?1 R:R:L198 3.65 14 Yes No 0 4 0 1
L:L:?1 R:R:N202 28.94 14 Yes Yes 0 5 0 1
L:L:?1 R:R:R267 25.61 14 Yes Yes 0 5 0 1
L:L:?1 R:R:H270 15.81 14 Yes No 0 4 0 1
L:L:?1 R:R:L271 17.02 14 Yes Yes 0 5 0 1
L:L:?1 R:R:K275 11.15 14 Yes No 0 1 0 1
R:R:L174 R:R:Y116 7.03 0 No No 5 5 2 1
R:R:S170 R:R:V120 4.85 0 No No 7 5 1 2
R:R:R267 R:R:Y123 4.12 14 Yes No 5 7 1 1
R:R:G209 R:R:Y127 4.35 0 No Yes 5 5 2 1
R:R:P213 R:R:Y127 5.56 0 No Yes 9 5 2 1
R:R:Q199 R:R:Y203 12.4 14 Yes No 3 4 2 2
R:R:L271 R:R:Q199 3.99 14 Yes Yes 5 3 1 2
R:R:N202 R:R:R267 13.26 14 Yes Yes 5 5 1 1
R:R:N202 R:R:T268 4.39 14 Yes No 5 6 1 2
R:R:L271 R:R:N202 13.73 14 Yes Yes 5 5 1 1
R:R:L271 R:R:Y203 22.27 14 Yes No 5 4 1 2
R:R:R267 R:R:Y263 4.12 14 Yes Yes 5 7 1 2
R:R:H270 R:R:W274 25.39 0 No Yes 4 3 1 2
R:R:I126 R:R:Y127 3.63 0 No Yes 7 5 2 1
R:R:L173 R:R:Y116 3.52 0 No No 5 5 2 1
R:R:A196 R:R:L198 3.15 0 No No 1 4 2 1
L:L:?1 R:R:S169 2.64 14 Yes No 0 5 0 1
L:L:?1 R:R:L165 2.43 14 Yes No 0 4 0 1
L:L:?1 R:R:A205 1.38 14 Yes No 0 5 0 1
R:R:E34 R:R:K275 1.35 0 No No 4 1 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub4.00
Average Interaction Strength12.55
Average Nodes In Shell29.00
Average Hubs In Shell8.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.75
Average Number Of Links With An Hub4.50
Average Interaction Strength8.48
Average Nodes In Shell26.50
Average Hubs In Shell10.75
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell28.75

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)