psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F91	4.75	Yes	Yes	1	0	8
2	L:L:?1	R:R:M112	6.43	Yes	No	0	0	7
3	L:L:?1	R:R:D115	19.41	Yes	No	1	0	9
4	L:L:?1	R:R:V116	9.68	Yes	No	0	0	9
5	L:L:?1	R:R:C119	5.16	Yes	No	0	0	8
6	L:L:?1	R:R:S196	5.86	Yes	No	0	0	9
7	L:L:?1	R:R:S200	3.9	Yes	No	1	0	8
8	L:L:?1	R:R:F362	14.25	Yes	Yes	1	0	8
9	L:L:?1	R:R:F363	10.29	Yes	Yes	1	0	8
10	L:L:?1	R:R:H366	11.7	Yes	Yes	1	0	7
11	L:L:?1	R:R:T386	3.83	Yes	No	1	0	6
12	L:L:?1	R:R:Y390	12.19	Yes	Yes	1	0	8
13	R:R:Q33	R:R:R380	9.35	No	No	0	3	3
14	R:R:L38	R:R:V96	5.96	No	No	0	8	6
15	R:R:G41	R:R:V92	5.52	No	No	0	7	8
16	R:R:L44	R:R:L88	4.15	No	No	0	7	8
17	R:R:I45	R:R:L88	5.71	No	No	0	7	8
18	R:R:I45	R:R:P89	5.08	No	No	0	7	9
19	R:R:S393	R:R:V48	4.85	No	No	0	9	8
20	R:R:G51	R:R:P397	4.06	No	No	0	9	9
21	R:R:A77	R:R:N52	4.69	No	Yes	0	9	9
22	R:R:D80	R:R:N52	13.46	Yes	Yes	0	9	9
23	R:R:L81	R:R:N52	4.12	No	Yes	0	8	9
24	R:R:N52	R:R:P397	13.03	Yes	No	0	9	9
25	R:R:A77	R:R:V55	5.09	No	No	0	9	9
26	R:R:F411	R:R:S58	6.61	Yes	No	0	8	9
27	R:R:V59	R:R:V74	4.81	No	No	0	8	8
28	R:R:A64	R:R:E62	4.53	No	No	0	7	8
29	R:R:E62	R:R:L65	7.95	No	Yes	0	8	8
30	R:R:A64	R:R:E406	4.53	No	No	0	7	7
31	R:R:E406	R:R:L65	3.98	No	Yes	0	7	8
32	R:R:F407	R:R:L65	13.4	Yes	Yes	0	8	8
33	R:R:L65	R:R:V410	4.47	Yes	No	0	8	8
34	R:R:P68	R:R:T67	3.5	No	No	0	7	8
35	R:R:N70	R:R:T67	8.77	No	No	0	9	8
36	R:R:G147	R:R:P68	4.06	No	No	4	7	7
37	R:R:P68	R:R:Q152	6.32	No	Yes	4	7	8
38	R:R:D132	R:R:T69	4.34	No	No	5	9	8
39	R:R:T69	R:R:Y143	6.24	No	Yes	5	8	8
40	R:R:F407	R:R:N70	7.25	Yes	No	0	8	9
41	R:R:F72	R:R:I129	3.77	Yes	No	0	8	9
42	R:R:D132	R:R:F72	11.94	No	Yes	0	9	8
43	R:R:F72	R:R:L155	7.31	Yes	No	0	8	6
44	R:R:F72	R:R:I156	8.79	Yes	No	0	8	8
45	R:R:I73	R:R:Y400	3.63	No	Yes	0	8	9
46	R:R:N125	R:R:S75	7.45	No	No	0	9	9
47	R:R:I156	R:R:S75	4.64	No	No	0	8	9
48	R:R:S75	R:R:W160	6.18	No	Yes	0	9	9
49	R:R:L76	R:R:N125	5.49	Yes	No	0	9	9
50	R:R:L126	R:R:L76	4.15	Yes	Yes	1	9	9
51	R:R:L76	R:R:N396	10.98	Yes	Yes	1	9	9
52	R:R:L76	R:R:Y400	3.52	Yes	Yes	1	9	9
53	R:R:D80	R:R:S122	4.42	Yes	No	0	9	9
54	R:R:D80	R:R:S393	11.78	Yes	No	0	9	9
55	R:R:D80	R:R:N396	6.73	Yes	Yes	0	9	9
56	R:R:L118	R:R:L82	5.54	No	No	0	7	7
57	R:R:L83	R:R:V87	4.47	No	Yes	0	8	8
58	R:R:L118	R:R:L83	4.15	No	No	0	7	8
59	R:R:L83	R:R:Y390	5.86	No	Yes	0	8	8
60	R:R:L86	R:R:M114	7.07	No	No	0	6	7
61	R:R:L111	R:R:V87	4.47	No	Yes	0	7	8
62	R:R:D115	R:R:V87	5.84	No	Yes	0	9	8
63	R:R:L88	R:R:Y390	8.21	No	Yes	0	8	8
64	R:R:L107	R:R:L90	4.15	Yes	No	0	4	6
65	R:R:L111	R:R:L90	6.92	No	No	0	7	6
66	R:R:E95	R:R:F91	9.33	No	Yes	1	6	8
67	R:R:F91	R:R:T386	6.49	Yes	No	1	8	6
68	R:R:F91	R:R:W387	15.03	Yes	No	1	8	8
69	R:R:F91	R:R:Y390	12.38	Yes	Yes	1	8	8
70	R:R:Q97	R:R:Y93	9.02	No	No	0	6	7
71	R:R:E95	R:R:S383	8.62	No	No	1	6	7
72	R:R:E95	R:R:W387	14.17	No	No	1	6	8
73	R:R:L102	R:R:Q97	9.32	No	No	0	4	6
74	R:R:L103	R:R:W101	7.97	No	Yes	2	6	8
75	R:R:L107	R:R:W101	5.69	Yes	Yes	2	4	8
76	R:R:C108	R:R:W101	6.53	No	Yes	2	9	8
77	R:R:C185	R:R:W101	10.45	No	Yes	2	9	8
78	R:R:L103	R:R:L107	4.15	No	Yes	2	6	4
79	R:R:P105	R:R:S104	3.56	No	No	0	4	7
80	R:R:D109	R:R:R106	11.91	No	No	0	7	4
81	R:R:D176	R:R:R106	10.72	No	No	0	6	4
82	R:R:C108	R:R:C185	7.28	No	No	2	9	9
83	R:R:D109	R:R:N175	8.08	No	No	0	7	6
84	R:R:L187	R:R:M112	5.65	No	No	0	7	7
85	R:R:A113	R:R:L171	4.73	No	No	0	8	8
86	R:R:D115	R:R:Y390	8.05	No	Yes	1	9	8
87	R:R:V116	R:R:Y192	3.79	No	Yes	0	9	8
88	R:R:C119	R:R:W359	3.92	No	Yes	0	8	9
89	R:R:F124	R:R:T120	3.89	Yes	Yes	1	7	8
90	R:R:S163	R:R:T120	6.4	No	Yes	1	8	8
91	R:R:T120	R:R:V166	6.35	Yes	No	1	8	8
92	R:R:S200	R:R:T120	9.59	No	Yes	1	8	8
93	R:R:A121	R:R:W160	5.19	No	Yes	0	8	9
94	R:R:I123	R:R:W359	15.27	No	Yes	0	9	9
95	R:R:F124	R:R:L162	7.31	Yes	No	0	7	6
96	R:R:F124	R:R:S163	3.96	Yes	No	1	7	8
97	R:R:F124	R:R:P204	5.78	Yes	No	0	7	9
98	R:R:N125	R:R:T159	10.24	No	No	0	9	8
99	R:R:L126	R:R:M208	4.24	Yes	Yes	1	9	8
100	R:R:L126	R:R:N396	5.49	Yes	Yes	1	9	9
101	R:R:L126	R:R:Y400	7.03	Yes	Yes	1	9	9
102	R:R:C127	R:R:P204	3.77	No	No	0	8	9
103	R:R:I129	R:R:R133	6.26	No	No	1	9	9
104	R:R:I129	R:R:Y400	8.46	No	Yes	1	9	9
105	R:R:M208	R:R:S130	7.67	Yes	No	1	8	9
106	R:R:S130	R:R:Y212	12.72	No	Yes	1	9	9
107	R:R:L155	R:R:V131	4.47	No	No	0	6	7
108	R:R:D132	R:R:Y143	10.34	No	Yes	5	9	8
109	R:R:R133	R:R:Y212	8.23	No	Yes	1	9	9
110	R:R:R133	R:R:Y400	5.14	No	Yes	1	9	9
111	R:R:A138	R:R:F134	8.32	No	Yes	0	7	8
112	R:R:F134	R:R:L211	3.65	Yes	No	0	8	8
113	R:R:A214	R:R:F134	4.16	No	Yes	0	7	8
114	R:R:F134	R:R:T215	5.19	Yes	No	0	8	9
115	R:R:V135	R:R:Y143	3.79	No	Yes	0	5	8
116	R:R:R151	R:R:V135	6.54	No	No	0	8	5
117	R:R:A136	R:R:Y143	8.01	No	Yes	0	9	8
118	R:R:L219	R:R:V137	4.47	No	No	0	8	8
119	R:R:R142	R:R:V139	7.85	No	No	0	5	6
120	R:R:G147	R:R:Q152	4.93	No	Yes	4	7	8
121	R:R:Q152	R:R:R151	3.5	Yes	No	0	8	8
122	R:R:T159	R:R:W160	6.06	No	Yes	0	8	9
123	R:R:S200	R:R:V166	4.85	No	No	1	8	8
124	R:R:P169	R:R:Y192	8.34	No	Yes	0	8	8
125	R:R:V170	R:R:Y192	3.79	No	Yes	0	8	8
126	R:R:L174	R:R:Y192	4.69	No	Yes	0	6	8
127	R:R:N175	R:R:R180	3.62	No	Yes	0	6	3
128	R:R:P182	R:R:R180	5.76	No	Yes	0	2	3
129	R:R:D181	R:R:P182	6.44	No	No	0	3	2
130	R:R:A183	R:R:D181	4.63	No	No	0	3	3
131	R:R:R186	R:R:V184	3.92	No	No	0	5	4
132	R:R:E188	R:R:R186	13.96	No	No	0	7	5
133	R:R:L187	R:R:Y192	5.86	No	Yes	0	7	8
134	R:R:D189	R:R:D191	5.32	No	No	0	5	5
135	R:R:P373	R:R:R190	12.97	No	No	0	1	6
136	R:R:S196	R:R:Y192	13.99	No	Yes	0	9	8
137	R:R:H366	R:R:V193	12.45	Yes	No	0	7	7
138	R:R:I367	R:R:V194	4.61	No	No	0	7	7
139	R:R:F363	R:R:S197	5.28	Yes	No	0	8	8
140	R:R:H366	R:R:S197	4.18	Yes	No	0	7	8
141	R:R:F201	R:R:F202	9.65	Yes	No	0	9	8
142	R:R:C205	R:R:F201	9.78	No	Yes	1	7	9
143	R:R:F201	R:R:F355	7.5	Yes	Yes	1	9	9
144	R:R:F201	R:R:T360	3.89	Yes	No	0	9	7
145	R:R:F201	R:R:F363	21.43	Yes	Yes	1	9	8
146	R:R:F202	R:R:I367	6.28	No	No	0	8	7
147	R:R:L203	R:R:L207	4.15	No	No	0	7	7
148	R:R:C205	R:R:P206	3.77	No	No	0	7	5
149	R:R:C205	R:R:F355	5.59	No	Yes	1	7	9
150	R:R:M208	R:R:Y212	3.59	Yes	Yes	1	8	9
151	R:R:F355	R:R:M208	8.71	Yes	Yes	1	9	8
152	R:R:L209	R:R:V352	4.47	No	No	0	6	7
153	R:R:L348	R:R:Y212	7.03	No	Yes	0	8	9
154	R:R:V351	R:R:Y212	5.05	No	Yes	0	9	9
155	R:R:V352	R:R:Y212	5.05	No	Yes	0	7	9
156	R:R:R217	R:R:W213	7	No	No	0	6	4
157	R:R:F216	R:R:Q220	9.37	No	No	0	7	7
158	R:R:F216	R:R:M345	9.95	No	No	0	7	8
159	R:R:R217	R:R:R221	8.53	No	No	0	6	5
160	R:R:E223	R:R:W222	5.45	No	No	0	7	7
161	R:R:R226	R:R:W222	4	No	No	0	7	7
162	R:R:M345	R:R:R346	3.72	No	No	0	8	7
163	R:R:F403	R:R:V347	11.8	No	No	0	8	8
164	R:R:F403	R:R:V350	6.55	No	No	0	8	7
165	R:R:V351	R:R:Y400	5.05	No	Yes	0	9	9
166	R:R:F355	R:R:L356	3.65	Yes	No	0	9	7
167	R:R:F355	R:R:W359	4.01	Yes	Yes	1	9	9
168	R:R:C358	R:R:W359	3.92	No	Yes	1	9	9
169	R:R:C358	R:R:N392	9.45	No	No	1	9	9
170	R:R:F363	R:R:W359	5.01	Yes	Yes	1	8	9
171	R:R:G389	R:R:W359	7.04	No	Yes	0	8	9
172	R:R:N392	R:R:W359	15.82	No	Yes	1	9	9
173	R:R:P361	R:R:T360	5.25	No	No	0	9	7
174	R:R:P361	R:R:V385	3.53	No	No	0	9	7
175	R:R:F362	R:R:F363	12.86	Yes	Yes	1	8	8
176	R:R:F362	R:R:H366	14.71	Yes	Yes	1	8	7
177	R:R:F362	R:R:T386	6.49	Yes	No	1	8	6
178	R:R:V365	R:R:V385	6.41	No	No	6	7	7
179	R:R:I367	R:R:L371	4.28	No	No	0	7	4
180	R:R:C372	R:R:C375	7.28	No	No	0	8	7
181	R:R:P378	R:R:V377	3.53	No	No	0	6	5
182	R:R:L381	R:R:P378	6.57	No	No	0	6	6
183	R:R:S383	R:R:W387	3.71	No	No	1	7	8
184	R:R:N392	R:R:N396	12.26	No	Yes	1	9	9
185	R:R:I399	R:R:Y400	3.63	No	Yes	0	9	9
186	R:R:F407	R:R:T401	14.27	Yes	No	3	8	8
187	R:R:F411	R:R:T401	3.89	Yes	No	3	8	8
188	R:R:F403	R:R:V402	5.24	No	No	0	8	6
189	R:R:F407	R:R:N404	7.25	Yes	No	0	8	9
190	R:R:E406	R:R:N409	6.57	No	No	0	7	5
191	R:R:F407	R:R:F411	5.36	Yes	Yes	3	8	8
192	R:R:N409	R:R:R412	6.03	No	No	0	5	5
193	R:R:D189	R:R:Y192	3.45	No	Yes	0	5	8
194	R:R:A79	R:R:S122	3.42	No	No	0	9	9
195	R:R:L219	R:R:W222	3.42	No	No	0	8	7
196	R:R:A84	R:R:V48	3.39	No	No	0	8	8
197	R:R:A113	R:R:V170	3.39	No	No	0	8	8
198	R:R:A167	R:R:V116	3.39	No	No	0	9	9
199	R:R:A370	R:R:V193	3.39	No	No	0	7	7
200	R:R:C375	R:R:T368	3.38	No	No	0	7	7
201	R:R:D176	R:R:G173	3.35	No	No	0	6	6
202	R:R:L203	R:R:P204	3.28	No	No	0	7	9
203	R:R:L388	R:R:P361	3.28	No	No	0	9	9
204	R:R:V377	R:R:V382	3.21	No	No	7	5	4
205	R:R:V398	R:R:V402	3.21	No	No	0	6	6
206	R:R:T215	R:R:V137	3.17	No	No	0	9	8
207	R:R:A84	R:R:L49	3.15	No	No	0	8	7
208	R:R:A128	R:R:L155	3.15	No	No	0	8	6
209	R:R:I45	R:R:V92	3.07	No	No	0	7	8
210	R:R:I399	R:R:V350	3.07	No	No	0	9	7
211	R:R:M114	R:R:V87	3.04	No	Yes	0	7	8
212	R:R:L107	R:R:S104	3	Yes	No	0	4	7
213	R:R:L211	R:R:S130	3	No	No	0	8	9
214	R:R:G179	R:R:R180	3	No	Yes	0	4	3
215	R:R:L381	R:R:V365	2.98	No	No	6	6	7
216	R:R:L381	R:R:V385	2.98	No	No	6	6	7
217	R:R:L388	R:R:V391	2.98	No	No	0	9	6
218	R:R:L395	R:R:V391	2.98	No	No	0	7	6
219	R:R:Q369	R:R:V377	2.87	No	No	7	4	5
220	R:R:Q369	R:R:V382	2.87	No	No	7	4	4
221	R:R:L49	R:R:L85	2.77	No	No	0	7	6
222	R:R:L85	R:R:L86	2.77	No	No	0	6	6
223	R:R:F407	R:R:V59	2.62	Yes	No	0	8	8
224	R:R:F411	R:R:L54	2.44	Yes	No	0	8	8
225	R:R:G40	R:R:G41	2.11	No	No	0	4	7
226	R:R:G98	R:R:G99	2.11	No	No	0	7	6
227	R:R:G147	R:R:G148	2.11	No	No	0	7	8
228	R:R:A37	R:R:G34	1.95	No	No	0	6	5
229	R:R:A50	R:R:G51	1.95	No	No	0	5	9
230	R:R:P378	R:R:P379	1.95	No	No	0	6	3
231	R:R:C372	R:R:P373	1.88	No	No	0	8	1
232	R:R:A168	R:R:P169	1.87	No	No	0	6	8
233	R:R:G99	R:R:S94	1.86	No	No	0	6	7
234	R:R:G40	R:R:V39	1.84	No	No	0	4	5
235	R:R:G218	R:R:V137	1.84	No	No	0	7	8
236	R:R:A77	R:R:C56	1.81	No	No	0	9	8
237	R:R:A374	R:R:C372	1.81	No	No	0	5	8
238	R:R:A394	R:R:A47	1.79	No	No	0	8	5
239	R:R:P140	R:R:V139	1.77	No	No	0	9	6
240	R:R:G40	R:R:L43	1.71	No	No	0	4	4
241	R:R:C199	R:R:V166	1.71	No	No	0	6	8
242	R:R:A37	R:R:V96	1.7	No	No	0	6	6
243	R:R:A394	R:R:V48	1.7	No	No	0	8	8
244	R:R:A138	R:R:V139	1.7	No	No	0	7	6
245	R:R:L348	R:R:P349	1.64	No	No	0	8	7
246	R:R:A354	R:R:I399	1.62	No	No	0	8	9
247	R:R:A164	R:R:M117	1.61	No	No	0	7	8
248	R:R:A167	R:R:M117	1.61	No	No	0	9	8
249	R:R:V92	R:R:V96	1.6	No	No	0	8	6
250	R:R:V194	R:R:V198	1.6	No	No	0	7	6
251	R:R:T61	R:R:V57	1.59	No	No	0	7	6
252	R:R:T368	R:R:V364	1.59	No	No	0	7	7
253	R:R:A100	R:R:L102	1.58	No	No	0	5	4
254	R:R:A344	R:R:L219	1.58	No	No	0	8	8
255	R:R:I156	R:R:S71	1.55	No	No	0	8	6
256	R:R:K343	R:R:V347	1.52	No	No	0	8	8
257	R:R:L81	R:R:S53	1.5	No	No	0	8	6
258	R:R:G218	R:R:R221	1.5	No	No	0	7	5
259	R:R:L38	R:R:V42	1.49	No	No	0	8	6
260	R:R:Q66	R:R:V59	1.43	No	No	0	7	8
261	R:R:A370	R:R:R190	1.38	No	No	0	7	6
262	R:R:L153	R:R:Q152	1.33	No	Yes	0	6	8
263	R:R:R106	R:R:S104	1.32	No	No	0	4	7
264	R:R:R408	R:R:V402	1.31	No	No	0	8	6
265	R:R:A78	R:R:W160	1.3	No	Yes	0	7	9
266	R:R:F216	R:R:L348	1.22	No	No	0	7	8
267	R:R:N144	R:R:R145	1.21	No	No	0	6	6
268	R:R:Q66	R:R:R63	1.17	No	No	0	7	8
269	R:R:Q146	R:R:R142	1.17	No	No	0	5	5
270	R:R:E188	R:R:R180	1.16	No	Yes	0	7	3
271	R:R:R342	R:R:R346	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.95417	12	1	0
2	R:R:N52	8.825	4	0	9
3	R:R:L65	7.45	4	0	8
4	R:R:F72	7.9525	4	0	8
5	R:R:L76	6.035	4	1	9
6	R:R:D80	9.0975	4	0	9
7	R:R:V87	4.455	4	0	8
8	R:R:F91	9.596	5	1	8
9	R:R:W101	7.66	4	2	8
10	R:R:L107	4.2475	4	2	4
11	R:R:T120	6.5575	4	1	8
12	R:R:F124	5.235	4	1	7
13	R:R:L126	5.2275	4	1	9
14	R:R:F134	5.33	4	0	8
15	R:R:Y143	7.095	4	5	8
16	R:R:Q152	4.02	4	4	8
17	R:R:W160	4.6825	4	0	9
18	R:R:R180	3.385	4	0	3
19	R:R:Y192	6.27286	7	0	8
20	R:R:F201	10.45	5	1	9
21	R:R:M208	6.0525	4	1	8
22	R:R:Y212	6.945	6	1	9
23	R:R:F355	5.892	5	1	9
24	R:R:W359	7.85571	7	1	9
25	R:R:F362	12.0775	4	1	8
26	R:R:F363	10.974	5	1	8
27	R:R:H366	10.76	4	1	7
28	R:R:Y390	9.338	5	1	8
29	R:R:N396	8.865	4	1	9
30	R:R:Y400	5.20857	7	1	9
31	R:R:F407	8.35833	6	3	8
32	R:R:F411	4.575	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	28.3624	12.19	Yes	Yes	1	0	8
2	R:R:L88	R:R:Y390	24.4054	8.21	No	Yes	0	8	8
3	R:R:I45	R:R:L88	21.126	5.71	No	No	0	7	8
4	R:R:I45	R:R:V92	17.6507	3.07	No	No	0	7	8
5	L:L:?1	R:R:C119	53.8648	5.16	Yes	No	0	0	8
6	R:R:C119	R:R:W359	54.2542	3.92	No	Yes	0	8	9
7	R:R:N392	R:R:W359	63.8274	15.82	No	Yes	1	9	9
8	R:R:N392	R:R:N396	63.8228	12.26	No	Yes	1	9	9
9	R:R:D80	R:R:N396	16.7519	6.73	Yes	Yes	0	9	9
10	L:L:?1	R:R:F363	84.7437	10.29	Yes	Yes	1	0	8
11	R:R:F363	R:R:W359	68.4504	5.01	Yes	Yes	1	8	9
12	R:R:F355	R:R:W359	60.7186	4.01	Yes	Yes	1	9	9
13	R:R:F355	R:R:M208	98.2232	8.71	Yes	Yes	1	9	8
14	R:R:L126	R:R:M208	43.8445	4.24	Yes	Yes	1	9	8
15	R:R:L126	R:R:Y400	65.1848	7.03	Yes	Yes	1	9	9
16	R:R:I129	R:R:Y400	70.3701	8.46	No	Yes	1	9	9
17	R:R:F72	R:R:I129	100	3.77	Yes	No	0	8	9
18	R:R:D132	R:R:F72	89.1962	11.94	No	Yes	0	9	8
19	R:R:D132	R:R:Y143	83.4025	10.34	No	Yes	5	9	8
20	R:R:V135	R:R:Y143	77.7125	3.79	No	Yes	0	5	8
21	R:R:R151	R:R:V135	74.8202	6.54	No	No	0	8	5
22	R:R:Q152	R:R:R151	72.3728	3.5	Yes	No	0	8	8
23	R:R:P68	R:R:Q152	60.6725	6.32	No	Yes	4	7	8
24	R:R:P68	R:R:T67	57.8655	3.5	No	No	0	7	8
25	R:R:N70	R:R:T67	54.9502	8.77	No	No	0	9	8
26	R:R:F407	R:R:N70	52.0211	7.25	Yes	No	0	8	9
27	R:R:F201	R:R:F363	39.4266	21.43	Yes	Yes	1	9	8
28	R:R:F201	R:R:F355	40.0973	7.5	Yes	Yes	1	9	9
29	R:R:L126	R:R:N396	28.9777	5.49	Yes	Yes	1	9	9
30	R:R:L76	R:R:N396	32.6742	10.98	Yes	Yes	1	9	9
31	R:R:L76	R:R:Y400	26.786	3.52	Yes	Yes	1	9	9
32	R:R:M208	R:R:Y212	40.4568	3.59	Yes	Yes	1	8	9
33	R:R:R133	R:R:Y212	34.0892	8.23	No	Yes	1	9	9
34	R:R:I129	R:R:R133	32.4253	6.26	No	No	1	9	9
35	R:R:F407	R:R:V59	11.9676	2.62	Yes	No	0	8	8
36	R:R:F407	R:R:L65	23.8915	13.4	Yes	Yes	0	8	8
37	R:R:E406	R:R:L65	11.9699	3.98	No	Yes	0	7	8
38	L:L:?1	R:R:D115	39.6317	19.41	Yes	No	1	0	9
39	R:R:D115	R:R:V87	39.5926	5.84	No	Yes	0	9	8
40	R:R:L111	R:R:V87	36.7625	4.47	No	Yes	0	7	8
41	R:R:L111	R:R:L90	35.3037	6.92	No	No	0	7	6
42	R:R:L107	R:R:L90	33.6375	4.15	Yes	No	0	4	6
43	R:R:L107	R:R:S104	25.2627	3	Yes	No	0	4	7
44	R:R:R106	R:R:S104	21.8796	1.32	No	No	0	4	7
45	R:R:D109	R:R:R106	16.9617	11.91	No	No	0	7	4
46	L:L:?1	R:R:V116	20.9324	9.68	Yes	No	0	0	9
47	R:R:V116	R:R:Y192	14.4082	3.79	No	Yes	0	9	8
48	L:L:?1	R:R:S196	16.056	5.86	Yes	No	0	0	9
49	R:R:S196	R:R:Y192	14.5165	13.99	No	Yes	0	9	8
50	L:L:?1	R:R:S200	18.5034	3.9	Yes	No	1	0	8
51	R:R:S200	R:R:T120	13.4748	9.59	No	Yes	1	8	8
52	R:R:F124	R:R:T120	10.147	3.89	Yes	Yes	1	7	8
53	R:R:M208	R:R:S130	18.8514	7.67	Yes	No	1	8	9
54	R:R:L211	R:R:S130	21.0776	3	No	No	0	8	9
55	R:R:F134	R:R:L211	20.0014	3.65	Yes	No	0	8	8
56	R:R:F134	R:R:T215	12.3387	5.19	Yes	No	0	8	9
57	R:R:T215	R:R:V137	11.221	3.17	No	No	0	9	8
58	R:R:D109	R:R:N175	15.2447	8.08	No	No	0	7	6
59	R:R:N175	R:R:R180	13.7168	3.62	No	Yes	0	6	3
60	L:L:?1	R:R:H366	16.8856	11.7	Yes	Yes	1	0	7
61	R:R:H366	R:R:V193	31.3168	12.45	Yes	No	0	7	7
62	R:R:A370	R:R:V193	27.8554	3.39	No	No	0	7	7
63	R:R:A370	R:R:R190	24.3893	1.38	No	No	0	7	6
64	R:R:P373	R:R:R190	20.9186	12.97	No	No	0	1	6
65	R:R:F363	R:R:S197	10.0756	5.28	Yes	No	0	8	8
66	R:R:I399	R:R:Y400	20.0705	3.63	No	Yes	0	9	9
67	R:R:I399	R:R:V350	15.5697	3.07	No	No	0	9	7
68	R:R:F403	R:R:V350	13.6269	6.55	No	No	0	8	7
69	R:R:C372	R:R:P373	17.4433	1.88	No	No	0	8	1
70	R:R:C372	R:R:C375	10.4789	7.28	No	No	0	8	7
71	R:R:F362	R:R:F363	10.7624	12.86	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F91	4.75	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M112	6.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:D115	19.41	1	Yes	No	0	9	0	1
L:L:?1	R:R:V116	9.68	1	Yes	No	0	9	0	1
L:L:?1	R:R:C119	5.16	1	Yes	No	0	8	0	1
L:L:?1	R:R:S196	5.86	1	Yes	No	0	9	0	1
L:L:?1	R:R:S200	3.9	1	Yes	No	0	8	0	1
L:L:?1	R:R:F362	14.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F363	10.29	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H366	11.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T386	3.83	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y390	12.19	1	Yes	Yes	0	8	0	1
R:R:L83	R:R:V87	4.47	0	No	Yes	8	8	2	2
R:R:L83	R:R:Y390	5.86	0	No	Yes	8	8	2	1
R:R:D115	R:R:V87	5.84	1	No	Yes	9	8	1	2
R:R:L88	R:R:Y390	8.21	0	No	Yes	8	8	2	1
R:R:E95	R:R:F91	9.33	1	No	Yes	6	8	2	1
R:R:F91	R:R:T386	6.49	1	Yes	No	8	6	1	1
R:R:F91	R:R:W387	15.03	1	Yes	No	8	8	1	2
R:R:F91	R:R:Y390	12.38	1	Yes	Yes	8	8	1	1
R:R:E95	R:R:W387	14.17	1	No	No	6	8	2	2
R:R:L187	R:R:M112	5.65	0	No	No	7	7	2	1
R:R:D115	R:R:Y390	8.05	1	No	Yes	9	8	1	1
R:R:V116	R:R:Y192	3.79	0	No	Yes	9	8	1	2
R:R:C119	R:R:W359	3.92	0	No	Yes	8	9	1	2
R:R:T120	R:R:V166	6.35	1	Yes	No	8	8	2	2
R:R:S200	R:R:T120	9.59	1	No	Yes	8	8	1	2
R:R:S200	R:R:V166	4.85	1	No	No	8	8	1	2
R:R:L187	R:R:Y192	5.86	0	No	Yes	7	8	2	2
R:R:S196	R:R:Y192	13.99	0	No	Yes	9	8	1	2
R:R:H366	R:R:V193	12.45	1	Yes	No	7	7	1	2
R:R:F363	R:R:S197	5.28	1	Yes	No	8	8	1	2
R:R:H366	R:R:S197	4.18	1	Yes	No	7	8	1	2
R:R:F201	R:R:F363	21.43	1	Yes	Yes	9	8	2	1
R:R:F363	R:R:W359	5.01	1	Yes	Yes	8	9	1	2
R:R:F362	R:R:F363	12.86	1	Yes	Yes	8	8	1	1
R:R:F362	R:R:H366	14.71	1	Yes	Yes	8	7	1	1
R:R:F362	R:R:T386	6.49	1	Yes	No	8	6	1	1
R:R:A167	R:R:V116	3.39	0	No	No	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IRU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	241
Number of Links	271
Number of Hubs	32
Number of Links mediated by Hubs	128
Number of Communities	7
Number of Nodes involved in Communities	51
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	89107
Length Of Smallest Path	3
Average Path Length	16.2148
Length of Longest Path	35
Minimum Path Strength	1.3
Average Path Strength	7.03091
Maximum Path Strength	17.145
Minimum Path Correlation	0.7
Average Path Correlation	0.913835
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	38.8335
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8013
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	R5F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	R5F
Name	Rotigotine
Synonyms	(6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Identifier
Formula	C19 H25 N O S
Molecular Weight	315.473
SMILES
PubChem	59227
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21917
Sequence	>8IRU_nogp_Chain_R G Q G A A A L V G G V L L I G A V L A G N S L V C V S V A T E R A L Q T P T N S F I V S L A A A D L L L A L L V L P L F V Y S E V Q G G A W L L S P R L C D A L M A M D V M L C T A S I F N L C A I S V D R F V A V A V P L R Y N R Q G G S R R Q L L L I G A T W L L S A A V A A P V L C G L N D V R G R D P A V C R L E D R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L Q R W E V A R R R K A M R V L P V V V G A F L L C W T P F F V V H I T Q A L C P A C S V P P R L V S A V T W L G Y V N S A L N P V I Y T V F N A E F R N V F R K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JD4	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu4	Homo sapiens	Glutamate	-	-	2.9	2023-06-21	10.1038/s41422-023-00830-2
	8IRU	A	Amine	Dopamine	D₄	Homo sapiens	Rotigotine	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	3.2	2023-06-07	10.1038/s41422-023-00808-0
	8IRU (No Gprot)	A	Amine	Dopamine	D₄	Homo sapiens	Rotigotine	-		3.2	2023-06-07	10.1038/s41422-023-00808-0
	8ID4	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID4 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	Linoleic acid	-		3.1	2023-03-15	10.1126/science.add6220
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7LD4	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-	Gi2/β1/γ2	3.3	2021-09-08	10.1038/s41586-021-03897-2
	7LD4 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-		3.3	2021-09-08	10.1038/s41586-021-03897-2
	6IQL	A	Amine	Dopamine	D₄	Mus musculus	L745870	-	-	3.5	2019-12-04	10.7554/eLife.48822
	6BD4	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	-	2.4	2018-08-22	10.1038/s41586-018-0447-x
	5WIV	A	Amine	Dopamine	D₄	Homo sapiens	Nemonapride	Na	-	2.14	2017-10-18	10.1126/science.aan5468
	5WIU	A	Amine	Dopamine	D₄	Homo sapiens	Nemonapride	-	-	1.96	2017-10-18	10.1126/science.aan5468
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	10.1016/j.str.2008.05.001

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Download 8IRU_nogp.zip

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