psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q9	R:R:S6	8.66	Yes	No	0	4	6
2	R:R:F8	R:R:I268	8.79	No	No	0	4	1
3	R:R:N70	R:R:Q9	7.92	No	Yes	1	3	4
4	R:R:Q9	R:R:Y271	6.76	Yes	Yes	1	4	3
5	R:R:I13	R:R:Y12	3.63	No	Yes	0	5	5
6	R:R:E16	R:R:Y12	17.96	Yes	Yes	1	6	5
7	R:R:N70	R:R:Y12	6.98	No	Yes	1	3	5
8	R:R:Y12	R:R:Y271	5.96	Yes	Yes	1	5	3
9	R:R:I274	R:R:Y12	8.46	Yes	Yes	1	5	5
10	R:R:I13	R:R:I67	11.77	No	No	0	5	6
11	R:R:F275	R:R:I15	12.56	Yes	No	0	5	5
12	R:R:E16	R:R:I63	8.2	Yes	Yes	1	6	6
13	R:R:E16	R:R:I67	4.1	Yes	No	0	6	6
14	R:R:E16	R:R:H278	12.31	Yes	Yes	1	6	7
15	R:R:F275	R:R:I19	3.77	Yes	No	0	5	7
16	R:R:A20	R:R:I63	4.87	No	Yes	0	5	6
17	R:R:S23	R:R:S281	4.89	No	No	0	8	9
18	R:R:A282	R:R:S23	3.42	No	No	0	6	8
19	R:R:P25	R:R:V24	5.3	No	No	0	4	6
20	R:R:V24	R:R:V56	3.21	No	No	0	6	7
21	R:R:D55	R:R:N27	6.73	Yes	No	0	9	9
22	R:R:N27	R:R:P285	11.4	No	No	0	9	9
23	R:R:F299	R:R:L29	4.87	No	No	0	7	7
24	R:R:A52	R:R:V30	3.39	No	No	0	9	9
25	R:R:P285	R:R:V30	3.53	No	No	0	9	9
26	R:R:F295	R:R:V30	7.87	Yes	No	0	9	9
27	R:R:I31	R:R:V49	4.61	No	No	0	7	5
28	R:R:A52	R:R:I31	3.25	No	No	0	9	7
29	R:R:V36	R:R:W32	6.13	No	No	0	5	4
30	R:R:V34	R:R:V49	3.21	No	No	0	8	5
31	R:R:A39	R:R:N37	4.69	No	No	0	6	6
32	R:R:L40	R:R:N37	6.87	No	No	0	8	6
33	R:R:N37	R:R:T298	4.39	No	No	0	6	6
34	R:R:F45	R:R:L40	18.27	Yes	No	0	8	8
35	R:R:K294	R:R:L40	4.23	No	No	0	6	8
36	R:R:D42	R:R:T44	4.34	No	No	0	7	8
37	R:R:D42	R:R:F45	7.17	No	Yes	0	7	8
38	R:R:D42	R:R:K116	4.15	No	No	0	7	4
39	R:R:D104	R:R:T44	8.67	No	No	0	9	8
40	R:R:R108	R:R:T44	6.47	No	No	0	8	8
41	R:R:F45	R:R:I292	6.28	Yes	No	0	8	8
42	R:R:F295	R:R:F45	4.29	Yes	Yes	0	9	8
43	R:R:A124	R:R:C46	3.61	No	No	0	7	4
44	R:R:D104	R:R:F47	7.17	No	Yes	0	9	8
45	R:R:F47	R:R:I128	3.77	Yes	No	0	8	8
46	R:R:I128	R:R:S50	9.29	No	No	0	8	9
47	R:R:D55	R:R:L51	6.79	Yes	Yes	2	9	9
48	R:R:A97	R:R:L51	3.15	No	Yes	0	8	9
49	R:R:L51	R:R:L98	5.54	Yes	No	2	9	8
50	R:R:L51	R:R:N284	10.98	Yes	Yes	2	9	9
51	R:R:A54	R:R:S93	3.42	No	No	0	8	7
52	R:R:D55	R:R:S94	5.89	Yes	No	0	9	9
53	R:R:D55	R:R:S281	4.42	Yes	No	0	9	9
54	R:R:D55	R:R:N284	10.77	Yes	Yes	2	9	9
55	R:R:A57	R:R:L90	3.15	No	No	0	6	7
56	R:R:G59	R:R:V58	3.68	No	No	0	7	8
57	R:R:V58	R:R:V62	6.41	No	No	0	8	6
58	R:R:S281	R:R:V58	8.08	No	No	0	9	8
59	R:R:L61	R:R:L90	5.54	No	No	0	5	7
60	R:R:L90	R:R:V62	4.47	No	No	0	7	6
61	R:R:H278	R:R:V62	4.15	Yes	No	0	7	6
62	R:R:I63	R:R:P64	3.39	Yes	No	0	6	8
63	R:R:H278	R:R:I63	6.63	Yes	Yes	1	7	6
64	R:R:L65	R:R:P86	3.28	No	No	0	5	4
65	R:R:A66	R:R:H278	4.39	No	Yes	0	7	7
66	R:R:L68	R:R:V83	5.96	No	No	0	4	6
67	R:R:N70	R:R:Y271	6.98	No	Yes	1	3	3
68	R:R:G72	R:R:P73	4.06	No	No	0	3	3
69	R:R:G72	R:R:K168	3.49	No	No	0	3	3
70	R:R:P73	R:R:T75	3.5	No	No	0	3	7
71	R:R:T75	R:R:T79	3.14	No	No	0	7	5
72	R:R:E164	R:R:Y76	7.86	No	No	0	3	6
73	R:R:F77	R:R:L81	3.65	Yes	No	3	3	5
74	R:R:F77	R:R:N147	4.83	Yes	Yes	3	3	6
75	R:R:F77	R:R:L149	4.87	Yes	No	3	3	4
76	R:R:F77	R:R:V152	3.93	Yes	No	0	3	1
77	R:R:F77	R:R:V174	6.55	Yes	Yes	3	3	3
78	R:R:H78	R:R:M82	5.25	No	No	0	1	4
79	R:R:C80	R:R:V83	3.42	No	No	0	9	6
80	R:R:C169	R:R:C80	7.28	No	No	3	9	9
81	R:R:C80	R:R:V174	5.12	No	Yes	3	9	3
82	R:R:L81	R:R:N147	6.87	No	Yes	3	5	6
83	R:R:M143	R:R:M82	4.33	No	No	0	5	4
84	R:R:C85	R:R:P86	3.77	No	No	0	6	4
85	R:R:C85	R:R:M143	4.86	No	No	0	6	5
86	L:L:?1	R:R:V87	6.88	Yes	No	0	0	6
87	R:R:L88	R:R:P142	3.28	Yes	Yes	1	4	4
88	R:R:F171	R:R:L88	4.87	Yes	Yes	1	4	4
89	R:R:L88	R:R:Y179	5.86	Yes	Yes	1	4	6
90	L:L:?1	R:R:L88	3.65	Yes	Yes	1	0	4
91	R:R:I89	R:R:S135	3.1	Yes	No	0	5	8
92	R:R:F136	R:R:I89	12.56	No	Yes	0	3	5
93	R:R:G139	R:R:I89	5.29	No	Yes	0	6	5
94	R:R:T91	R:R:W247	3.64	No	Yes	0	6	8
95	L:L:?1	R:R:T91	11.68	Yes	No	0	0	6
96	R:R:I95	R:R:Q92	4.12	Yes	Yes	0	8	6
97	R:R:L96	R:R:Q92	7.99	No	Yes	0	4	6
98	R:R:Q92	R:R:W188	7.67	Yes	Yes	0	6	8
99	R:R:S93	R:R:W132	12.36	No	No	0	7	9
100	R:R:S135	R:R:S93	4.89	No	No	0	8	7
101	R:R:I95	R:R:V189	4.61	Yes	No	2	8	5
102	R:R:I95	R:R:P192	3.39	Yes	No	0	8	8
103	R:R:F243	R:R:I95	6.28	No	Yes	2	9	8
104	R:R:I95	R:R:W247	18.79	Yes	Yes	2	8	8
105	R:R:C131	R:R:L96	3.17	No	No	0	7	4
106	R:R:L98	R:R:N284	6.87	No	Yes	2	8	9
107	R:R:L98	R:R:Y288	4.69	No	Yes	2	8	9
108	R:R:L99	R:R:P192	3.28	No	No	0	7	8
109	R:R:I101	R:R:R105	6.26	No	No	2	9	9
110	R:R:I101	R:R:Y288	6.04	No	Yes	2	9	9
111	R:R:A102	R:R:I199	3.25	No	No	0	9	6
112	R:R:A102	R:R:Y200	4	No	Yes	0	9	9
113	R:R:I199	R:R:V103	3.07	No	No	0	6	6
114	R:R:D104	R:R:Y115	5.75	No	Yes	0	9	7
115	R:R:R105	R:R:Y200	4.12	No	Yes	0	9	9
116	R:R:R105	R:R:Y288	8.23	No	Yes	2	9	9
117	R:R:K110	R:R:Y106	13.14	No	No	0	7	7
118	R:R:E202	R:R:Y106	5.61	No	No	0	4	7
119	R:R:I111	R:R:L107	4.28	No	No	0	6	5
120	R:R:R108	R:R:Y115	25.72	No	Yes	0	8	7
121	R:R:L206	R:R:V109	5.96	No	No	0	5	9
122	R:R:I207	R:R:V109	3.07	No	No	0	8	9
123	R:R:I111	R:R:R114	6.26	No	No	0	6	5
124	R:R:K116	R:R:Y115	8.36	No	Yes	0	4	7
125	R:R:V119	R:R:Y115	7.57	No	Yes	0	7	7
126	R:R:P121	R:R:T120	5.25	No	No	0	3	8
127	R:R:R123	R:R:T120	5.17	No	No	0	5	8
128	R:R:G130	R:R:I133	3.53	No	No	0	1	4
129	R:R:L134	R:R:W188	6.83	No	Yes	0	4	8
130	R:R:F183	R:R:V138	5.24	Yes	No	1	5	5
131	R:R:V138	R:R:W188	13.48	No	Yes	1	5	8
132	R:R:P142	R:R:T141	3.5	Yes	No	1	4	6
133	R:R:T141	R:R:W146	4.85	No	Yes	1	6	6
134	R:R:T141	R:R:Y179	3.75	No	Yes	1	6	6
135	R:R:I175	R:R:P142	5.08	No	Yes	0	3	4
136	R:R:P142	R:R:Y179	12.52	Yes	Yes	1	4	6
137	R:R:G145	R:R:N147	3.39	No	Yes	0	5	6
138	R:R:E178	R:R:W146	3.27	No	Yes	0	3	6
139	R:R:W146	R:R:Y179	7.72	Yes	Yes	1	6	6
140	R:R:F183	R:R:W146	5.01	Yes	Yes	1	5	6
141	R:R:L149	R:R:N147	4.12	No	Yes	3	4	6
142	R:R:A151	R:R:N148	3.13	No	No	0	3	4
143	R:R:E153	R:R:L149	7.95	No	No	0	2	4
144	R:R:P165	R:R:V152	3.53	No	No	0	5	1
145	R:R:S161	R:R:W156	14.83	No	No	0	6	1
146	R:R:P165	R:R:W156	12.16	No	No	0	5	1
147	R:R:V166	R:R:W156	3.68	No	No	0	3	1
148	R:R:E164	R:R:P165	3.14	No	No	0	3	5
149	R:R:C169	R:R:V174	3.42	No	Yes	3	9	3
150	R:R:F171	R:R:I175	11.3	Yes	No	0	4	3
151	L:L:?1	R:R:F171	20.1	Yes	Yes	1	0	4
152	L:L:?1	R:R:E172	7.87	Yes	No	0	0	4
153	R:R:I175	R:R:V174	3.07	No	Yes	0	3	3
154	R:R:E178	R:R:S176	7.19	No	No	0	3	5
155	R:R:M177	R:R:M180	4.33	No	No	0	3	5
156	R:R:M177	R:R:N254	4.21	No	No	0	3	5
157	R:R:M180	R:R:Y179	4.79	No	Yes	0	5	6
158	R:R:F183	R:R:Y179	4.13	Yes	Yes	1	5	6
159	R:R:M180	R:R:N184	7.01	No	No	0	5	5
160	R:R:V181	R:R:Y182	3.79	No	No	4	4	4
161	R:R:L258	R:R:V181	5.96	Yes	No	4	4	4
162	R:R:L258	R:R:Y182	4.69	Yes	No	4	4	4
163	R:R:F259	R:R:Y182	7.22	No	No	4	4	4
164	R:R:F183	R:R:W188	9.02	Yes	Yes	1	5	8
165	R:R:F185	R:R:F186	7.5	Yes	No	0	5	4
166	R:R:F185	R:R:V189	3.93	Yes	No	2	5	5
167	R:R:F185	R:R:L190	4.87	Yes	No	0	5	5
168	R:R:F185	R:R:H251	15.84	Yes	No	2	5	7
169	R:R:V187	R:R:W188	8.58	No	Yes	0	5	8
170	R:R:H251	R:R:V189	12.45	No	No	2	7	5
171	R:R:P191	R:R:P192	5.84	No	No	0	4	8
172	R:R:F243	R:R:L193	7.31	No	No	2	9	6
173	R:R:L193	R:R:L248	4.15	No	No	2	6	7
174	R:R:L240	R:R:V197	4.47	No	No	0	8	5
175	R:R:L236	R:R:Y200	8.21	No	Yes	0	8	9
176	R:R:I239	R:R:Y200	7.25	No	Yes	0	8	9
177	R:R:L240	R:R:Y200	8.21	No	Yes	0	8	9
178	R:R:I207	R:R:V203	3.07	No	No	0	8	9
179	R:R:F204	R:R:R208	3.21	No	No	0	6	5
180	R:R:E229	R:R:F204	5.83	No	No	0	6	6
181	R:R:R208	R:R:Y205	6.17	No	No	0	5	4
182	R:R:I207	R:R:I232	4.42	No	No	0	8	7
183	R:R:N212	R:R:R208	6.03	No	No	0	5	5
184	R:R:K213	R:R:Q210	6.78	No	No	0	3	7
185	R:R:K224	R:R:Y225	9.55	No	No	0	3	3
186	R:R:L230	R:R:Y226	4.69	No	No	0	5	1
187	R:R:K228	R:R:K231	4.31	No	No	0	6	7
188	R:R:R291	R:R:S235	10.54	No	No	0	7	8
189	R:R:L238	R:R:L242	5.54	No	No	0	6	6
190	R:R:I239	R:R:Y288	3.63	No	Yes	0	8	9
191	R:R:F241	R:R:L245	8.53	No	No	0	5	6
192	R:R:L242	R:R:M283	7.07	No	No	0	6	6
193	R:R:F243	R:R:W247	11.02	No	Yes	2	9	8
194	R:R:S246	R:R:W247	3.71	No	Yes	2	8	8
195	R:R:N280	R:R:S246	7.45	No	No	2	9	8
196	R:R:H251	R:R:W247	3.17	No	Yes	2	7	8
197	R:R:T277	R:R:W247	6.06	No	Yes	0	7	8
198	R:R:N280	R:R:W247	6.78	No	Yes	2	9	8
199	R:R:A273	R:R:L250	3.15	No	Yes	0	5	6
200	R:R:I274	R:R:L250	4.28	Yes	Yes	1	5	6
201	R:R:L250	R:R:T277	7.37	Yes	No	0	6	7
202	L:L:?1	R:R:L250	10.96	Yes	Yes	1	0	6
203	R:R:K265	R:R:L253	4.23	Yes	No	0	3	4
204	L:L:?1	R:R:N254	9.07	Yes	No	0	0	5
205	R:R:K265	R:R:T257	7.51	Yes	No	0	3	4
206	R:R:F259	R:R:L258	3.65	No	Yes	4	4	4
207	R:R:C260	R:R:C263	7.28	No	No	0	4	2
208	R:R:K265	R:R:T270	4.5	Yes	No	0	3	4
209	R:R:L269	R:R:P266	9.85	No	No	0	4	4
210	R:R:S267	R:R:Y271	5.09	No	Yes	0	3	3
211	R:R:I268	R:R:I272	4.42	No	No	0	1	3
212	R:R:F275	R:R:I272	7.54	Yes	No	0	5	3
213	R:R:H278	R:R:I274	3.98	Yes	Yes	1	7	5
214	L:L:?1	R:R:I274	6.6	Yes	Yes	1	0	5
215	R:R:F275	R:R:L276	3.65	Yes	No	0	5	7
216	L:L:?1	R:R:H278	6.79	Yes	Yes	1	0	7
217	R:R:N280	R:R:N284	10.9	No	Yes	2	9	9
218	R:R:A289	R:R:F295	8.32	No	Yes	0	7	9
219	R:R:F290	R:R:R296	7.48	No	No	0	6	8
220	R:R:Q293	R:R:R296	10.51	No	No	0	4	8
221	R:R:M117	R:R:V118	3.04	No	No	0	5	4
222	R:R:N148	R:R:S176	2.98	No	No	0	4	5
223	R:R:N27	R:R:V56	2.96	No	No	0	9	7
224	R:R:I167	R:R:K173	2.91	No	No	0	4	3
225	R:R:Q92	R:R:S135	2.89	Yes	No	0	6	8
226	R:R:Q293	R:R:V297	2.87	No	No	0	4	4
227	R:R:I89	R:R:L140	2.85	Yes	No	0	5	4
228	R:R:I256	R:R:L253	2.85	No	No	0	4	4
229	R:R:L258	R:R:M177	2.83	Yes	No	0	4	3
230	R:R:L240	R:R:M196	2.83	No	No	0	8	8
231	R:R:K110	R:R:L206	2.82	No	No	0	7	5
232	R:R:K209	R:R:L206	2.82	No	No	0	4	5
233	R:R:K234	R:R:L230	2.82	No	No	0	7	5
234	R:R:C255	R:R:F259	2.79	No	No	0	5	4
235	R:R:A33	R:R:F295	2.77	No	Yes	0	8	9
236	R:R:A100	R:R:F47	2.77	No	Yes	0	7	8
237	R:R:A124	R:R:F47	2.77	No	Yes	0	7	8
238	R:R:A84	R:R:F171	2.77	No	Yes	0	4	4
239	R:R:L195	R:R:L99	2.77	No	No	0	6	7
240	R:R:L190	R:R:L194	2.77	No	No	0	5	3
241	R:R:A233	R:R:F204	2.77	No	No	0	7	6
242	R:R:I5	R:R:Q9	2.74	No	Yes	0	4	4
243	R:R:H78	R:R:L81	2.57	No	No	0	1	5
244	R:R:E170	R:R:E172	2.54	No	No	0	4	4
245	R:R:V203	R:R:Y200	2.52	No	Yes	0	9	9
246	R:R:V287	R:R:Y288	2.52	No	Yes	0	8	9
247	R:R:F45	R:R:I48	2.51	Yes	No	0	8	8
248	R:R:F171	R:R:I69	2.51	Yes	No	0	4	3
249	R:R:F77	R:R:I167	2.51	Yes	No	0	3	4
250	R:R:T79	R:R:Y76	2.5	No	No	0	5	6
251	R:R:M117	R:R:R114	2.48	No	No	0	5	5
252	R:R:F241	R:R:L242	2.44	No	No	0	5	6
253	R:R:F299	R:R:L300	2.44	No	No	0	7	5
254	R:R:L300	R:R:R296	2.43	No	No	0	5	8
255	R:R:Q38	R:R:R41	2.34	No	No	0	6	7
256	R:R:L107	R:R:Y106	2.34	No	No	0	5	7
257	R:R:L107	R:R:Y115	2.34	No	Yes	0	5	7
258	R:R:E16	R:R:F275	2.33	Yes	Yes	0	6	5
259	R:R:K35	R:R:W32	2.32	No	No	0	3	4
260	R:R:L29	R:R:W32	2.28	No	No	0	7	4
261	R:R:E229	R:R:Y226	2.24	No	No	0	6	1
262	R:R:G26	R:R:P25	2.03	No	No	0	8	4
263	R:R:C260	R:R:P261	1.88	No	No	0	4	4
264	R:R:G14	R:R:V17	1.84	No	No	0	5	4
265	R:R:G14	R:R:I13	1.76	No	No	0	5	5
266	R:R:G279	R:R:I19	1.76	No	No	0	5	7
267	R:R:G163	R:R:M162	1.75	No	No	0	4	4
268	R:R:G26	R:R:L29	1.71	No	No	0	8	7
269	R:R:A43	R:R:V119	1.7	No	No	0	6	7
270	R:R:I111	R:R:P112	1.69	No	No	0	6	8
271	R:R:K265	R:R:P266	1.67	Yes	No	0	3	4
272	R:R:L248	R:R:P249	1.64	No	No	0	7	9
273	R:R:L276	R:R:P249	1.64	No	No	0	7	9
274	R:R:A157	R:R:M162	1.61	No	No	0	1	4
275	R:R:V137	R:R:V138	1.6	No	No	0	4	5
276	R:R:A60	R:R:L61	1.58	No	No	0	4	5
277	R:R:A244	R:R:L193	1.58	No	No	2	6	6
278	R:R:A244	R:R:L248	1.58	No	No	2	6	7
279	R:R:A273	R:R:L253	1.58	No	No	0	5	4
280	R:R:I31	R:R:V53	1.54	No	No	0	7	6
281	R:R:I286	R:R:V287	1.54	No	No	0	7	8
282	R:R:M283	R:R:S246	1.53	No	No	0	6	8
283	R:R:L21	R:R:V17	1.49	No	No	0	5	4
284	R:R:I5	R:R:I71	1.47	No	No	0	4	4
285	R:R:I67	R:R:I71	1.47	No	No	0	6	4
286	R:R:I252	R:R:I256	1.47	No	No	0	6	4
287	R:R:I15	R:R:L18	1.43	No	No	0	5	5
288	R:R:I19	R:R:L18	1.43	No	No	0	7	5
289	R:R:I232	R:R:L211	1.43	No	No	0	7	4
290	R:R:A7	R:R:F8	1.39	No	No	0	5	4
291	R:R:A127	R:R:F47	1.39	No	Yes	0	5	8
292	R:R:H264	R:R:S262	1.39	No	No	0	2	3
293	R:R:L211	R:R:N212	1.37	No	No	0	4	5
294	R:R:R154	R:R:S150	1.32	No	No	0	2	2
295	R:R:R41	R:R:V34	1.31	No	No	0	7	8
296	R:R:R122	R:R:T120	1.29	No	No	0	5	8
297	R:R:L238	R:R:R291	1.21	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q9	6.52	4	1	4
2	R:R:Y12	8.598	5	1	5
3	R:R:E16	8.98	5	1	6
4	R:R:F45	7.704	5	0	8
5	R:R:F47	3.574	5	0	8
6	R:R:L51	6.615	4	2	9
7	R:R:D55	6.92	5	2	9
8	R:R:I63	5.7725	4	1	6
9	R:R:F77	4.39	6	3	3
10	R:R:L88	4.415	4	1	4
11	R:R:I89	5.95	4	0	5
12	R:R:Q92	5.6675	4	0	6
13	R:R:I95	7.438	5	2	8
14	R:R:Y115	9.948	5	0	7
15	R:R:P142	6.095	4	1	4
16	R:R:W146	5.2125	4	1	6
17	R:R:N147	4.8025	4	3	6
18	R:R:F171	8.31	5	1	4
19	R:R:V174	4.54	4	3	3
20	R:R:Y179	6.46167	6	1	6
21	R:R:F183	5.85	4	1	5
22	R:R:F185	8.035	4	2	5
23	R:R:W188	9.116	5	1	8
24	R:R:Y200	5.71833	6	0	9
25	R:R:W247	7.59571	7	2	8
26	R:R:L250	6.44	4	1	6
27	R:R:L258	4.2825	4	4	4
28	R:R:K265	4.4775	4	0	3
29	R:R:Y271	6.1975	4	1	3
30	R:R:I274	5.83	4	1	5
31	R:R:F275	5.97	5	0	5
32	R:R:H278	6.375	6	1	7
33	R:R:N284	9.88	4	2	9
34	R:R:Y288	5.022	5	2	9
35	R:R:F295	5.8125	4	0	9
36	L:L:?1	9.28889	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E16	R:R:F275	25.0337	2.33	Yes	Yes	0	6	5
2	R:R:Y12	R:R:Y271	11.5769	5.96	Yes	Yes	1	5	3
3	R:R:I13	R:R:Y12	10.303	3.63	No	Yes	0	5	5
4	R:R:I274	R:R:Y12	27.7273	8.46	Yes	Yes	1	5	5
5	R:R:E16	R:R:H278	37.1324	12.31	Yes	Yes	1	6	7
6	R:R:H278	R:R:V62	57.4467	4.15	Yes	No	0	7	6
7	R:R:V58	R:R:V62	57.615	6.41	No	No	0	8	6
8	R:R:S281	R:R:V58	58.0976	8.08	No	No	0	9	8
9	R:R:P25	R:R:V24	26.8294	5.3	No	No	0	4	6
10	R:R:V24	R:R:V56	29.0123	3.21	No	No	0	6	7
11	R:R:N27	R:R:V56	31.1841	2.96	No	No	0	9	7
12	R:R:D55	R:R:N27	94.1526	6.73	Yes	No	0	9	9
13	R:R:D55	R:R:S281	59.4444	4.42	Yes	No	0	9	9
14	R:R:N27	R:R:P285	68.1987	11.4	No	No	0	9	9
15	R:R:F299	R:R:L29	13.4961	4.87	No	No	0	7	7
16	R:R:G26	R:R:L29	22.4299	1.71	No	No	0	8	7
17	R:R:G26	R:R:P25	24.6352	2.03	No	No	0	8	4
18	R:R:A52	R:R:V30	15.6285	3.39	No	No	0	9	9
19	R:R:P285	R:R:V30	66.4198	3.53	No	No	0	9	9
20	R:R:F295	R:R:V30	51.9641	7.87	Yes	No	0	9	9
21	R:R:A52	R:R:I31	13.4287	3.25	No	No	0	9	7
22	R:R:F45	R:R:L40	10.1235	18.27	Yes	No	0	8	8
23	R:R:F295	R:R:F45	47.5309	4.29	Yes	Yes	0	9	8
24	R:R:D42	R:R:F45	35.202	7.17	No	Yes	0	7	8
25	R:R:D42	R:R:T44	15.6229	4.34	No	No	0	7	8
26	R:R:D42	R:R:K116	18.165	4.15	No	No	0	7	4
27	R:R:D104	R:R:T44	12.7497	8.67	No	No	0	9	8
28	R:R:D104	R:R:F47	12.8339	7.17	No	Yes	0	9	8
29	R:R:D55	R:R:L51	20.0281	6.79	Yes	Yes	2	9	9
30	R:R:N280	R:R:N284	100	10.9	No	Yes	2	9	9
31	R:R:N280	R:R:W247	94.5062	6.78	No	Yes	2	9	8
32	R:R:T91	R:R:W247	68.8664	3.64	No	Yes	0	6	8
33	L:L:?1	R:R:T91	68.5802	11.68	Yes	No	0	0	6
34	L:L:?1	R:R:I274	13.9001	6.6	Yes	Yes	1	0	5
35	R:R:T277	R:R:W247	18.2772	6.06	No	Yes	0	7	8
36	R:R:L250	R:R:T277	18.1818	7.37	Yes	No	0	6	7
37	R:R:I274	R:R:L250	12.0595	4.28	Yes	Yes	1	5	6
38	R:R:L98	R:R:N284	76.532	6.87	No	Yes	2	8	9
39	R:R:Q92	R:R:S135	13.5971	2.89	Yes	No	0	6	8
40	R:R:I95	R:R:Q92	24.7475	4.12	Yes	Yes	0	8	6
41	R:R:I95	R:R:W247	30.1852	18.79	Yes	Yes	2	8	8
42	R:R:H78	R:R:L81	11.6442	2.57	No	No	0	1	5
43	R:R:F77	R:R:L81	13.3895	3.65	Yes	No	3	3	5
44	R:R:F77	R:R:V174	46.7228	6.55	Yes	Yes	3	3	3
45	R:R:I175	R:R:V174	54.5174	3.07	No	Yes	0	3	3
46	R:R:F171	R:R:I175	49.1919	11.3	Yes	No	0	4	3
47	L:L:?1	R:R:F171	53.0696	20.1	Yes	Yes	1	0	4
48	R:R:E164	R:R:Y76	11.5769	7.86	No	No	0	3	6
49	R:R:E164	R:R:P165	13.468	3.14	No	No	0	3	5
50	R:R:P165	R:R:V152	20.9147	3.53	No	No	0	5	1
51	R:R:F77	R:R:V152	22.5533	3.93	Yes	No	0	3	1
52	L:L:?1	R:R:L88	19.1863	3.65	Yes	Yes	1	0	4
53	R:R:L88	R:R:Y179	15.4265	5.86	Yes	Yes	1	4	6
54	R:R:F183	R:R:W188	10.5556	9.02	Yes	Yes	1	5	8
55	R:R:L98	R:R:Y288	94.422	4.69	No	Yes	2	8	9
56	R:R:R105	R:R:Y288	44.2031	8.23	No	Yes	2	9	9
57	R:R:A102	R:R:Y200	11.257	4	No	Yes	0	9	9
58	R:R:R105	R:R:Y200	43.0303	4.12	No	Yes	0	9	9
59	R:R:I239	R:R:Y200	42.8171	7.25	No	Yes	0	8	9
60	R:R:I239	R:R:Y288	44.3603	3.63	No	Yes	0	8	9
61	R:R:K116	R:R:Y115	16.9529	8.36	No	Yes	0	4	7
62	R:R:K110	R:R:L206	11.431	2.82	No	No	0	7	5
63	R:R:L206	R:R:V109	17.3232	5.96	No	No	0	5	9
64	R:R:I207	R:R:V109	20.1347	3.07	No	No	0	8	9
65	R:R:I207	R:R:V203	56.9416	3.07	No	No	0	8	9
66	R:R:V203	R:R:Y200	60.0337	2.52	No	Yes	0	9	9
67	R:R:L107	R:R:Y115	15.0898	2.34	No	Yes	0	5	7
68	R:R:E178	R:R:W146	11.257	3.27	No	Yes	0	3	6
69	R:R:M177	R:R:N254	13.2772	4.21	No	No	0	3	5
70	L:L:?1	R:R:N254	15.0112	9.07	Yes	No	0	0	5
71	R:R:L258	R:R:M177	10.2637	2.83	Yes	No	0	4	3
72	R:R:L240	R:R:Y200	11.1785	8.21	No	Yes	0	8	9
73	R:R:F204	R:R:R208	21.2963	3.21	No	No	0	6	5
74	R:R:N212	R:R:R208	28.3109	6.03	No	No	0	5	5
75	R:R:L211	R:R:N212	31.8013	1.37	No	No	0	4	5
76	R:R:I232	R:R:L211	35.275	1.43	No	No	0	7	4
77	R:R:I207	R:R:I232	38.4736	4.42	No	No	0	8	7
78	R:R:E229	R:R:F204	14.2368	5.83	No	No	0	6	6
79	R:R:E229	R:R:Y226	10.7015	2.24	No	No	0	6	1
80	R:R:M283	R:R:S246	11.532	1.53	No	No	0	6	8
81	R:R:A273	R:R:L250	16.2009	3.15	No	Yes	0	5	6
82	R:R:A273	R:R:L253	14.4276	1.58	No	No	0	5	4
83	R:R:F299	R:R:L300	11.4703	2.44	No	No	0	7	5
84	R:R:L51	R:R:L98	19.3996	5.54	Yes	No	2	9	8
85	R:R:D55	R:R:N284	59.1246	10.77	Yes	Yes	2	9	9
86	L:L:?1	R:R:H278	43.5129	6.79	Yes	Yes	1	0	7
87	R:R:Q92	R:R:W188	13.5129	7.67	Yes	Yes	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E16	R:R:Y12	17.96	1	Yes	Yes	6	5	2	2
R:R:I274	R:R:Y12	8.46	1	Yes	Yes	5	5	1	2
R:R:E16	R:R:I63	8.2	1	Yes	Yes	6	6	2	2
R:R:E16	R:R:H278	12.31	1	Yes	Yes	6	7	2	1
R:R:H278	R:R:V62	4.15	1	Yes	No	7	6	1	2
R:R:H278	R:R:I63	6.63	1	Yes	Yes	7	6	1	2
R:R:A66	R:R:H278	4.39	0	No	Yes	7	7	2	1
L:L:?1	R:R:V87	6.88	1	Yes	No	0	6	0	1
R:R:L88	R:R:P142	3.28	1	Yes	Yes	4	4	1	2
R:R:F171	R:R:L88	4.87	1	Yes	Yes	4	4	1	1
R:R:L88	R:R:Y179	5.86	1	Yes	Yes	4	6	1	2
L:L:?1	R:R:L88	3.65	1	Yes	Yes	0	4	0	1
R:R:T91	R:R:W247	3.64	0	No	Yes	6	8	1	2
L:L:?1	R:R:T91	11.68	1	Yes	No	0	6	0	1
R:R:I175	R:R:P142	5.08	0	No	Yes	3	4	2	2
R:R:P142	R:R:Y179	12.52	1	Yes	Yes	4	6	2	2
R:R:F171	R:R:I175	11.3	1	Yes	No	4	3	1	2
L:L:?1	R:R:F171	20.1	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:E172	7.87	1	Yes	No	0	4	0	1
R:R:M177	R:R:N254	4.21	0	No	No	3	5	2	1
R:R:T277	R:R:W247	6.06	0	No	Yes	7	8	2	2
R:R:A273	R:R:L250	3.15	0	No	Yes	5	6	2	1
R:R:I274	R:R:L250	4.28	1	Yes	Yes	5	6	1	1
R:R:L250	R:R:T277	7.37	1	Yes	No	6	7	1	2
L:L:?1	R:R:L250	10.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N254	9.07	1	Yes	No	0	5	0	1
R:R:H278	R:R:I274	3.98	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:I274	6.6	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H278	6.79	1	Yes	Yes	0	7	0	1
R:R:A84	R:R:F171	2.77	0	No	Yes	4	4	2	1
R:R:E170	R:R:E172	2.54	0	No	No	4	4	2	1
R:R:F171	R:R:I69	2.51	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7LD4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	269
Number of Links	297
Number of Hubs	36
Number of Links mediated by Hubs	139
Number of Communities	4
Number of Nodes involved in Communities	48
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	49425
Length Of Smallest Path	3
Average Path Length	13.6028
Length of Longest Path	33
Minimum Path Strength	1.4
Average Path Strength	6.15769
Maximum Path Strength	17.04
Minimum Path Correlation	0.7
Average Path Correlation	0.928709
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	52.2151
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.7394
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • nucleoside binding • heterocyclic compound binding • carbohydrate derivative binding • purine nucleoside binding • small molecule binding • G protein-coupled adenosine receptor activity • heat shock protein binding • G-protein beta/gamma-subunit complex binding • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • signaling receptor binding • G protein-coupled receptor binding • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of long-term synaptic potentiation • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • negative regulation of biological process • long-term synaptic potentiation • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • regulation of signaling • positive regulation of synaptic transmission • regulation of trans-synaptic signaling • regulation of long-term synaptic potentiation • regulation of cell communication • positive regulation of signaling • regulation of localization • nitrogen compound transport • regulation of transport • transport • regulation of nucleobase-containing compound transport • nucleoside transport • positive regulation of nucleoside transport • carbohydrate derivative transport • positive regulation of nucleobase-containing compound transport • establishment of localization • localization • positive regulation of transport • regulation of nucleoside transport • nucleobase-containing compound transport • import into cell • phagocytosis • endocytosis • vesicle-mediated transport • chemical homeostasis • homeostatic process • triglyceride homeostasis • acylglycerol homeostasis • lipid homeostasis • regulation of body fluid levels • secretion by tissue • secretion • mucus secretion • body fluid secretion • cognition • protein localization • establishment of protein localization • cellular localization • establishment of protein localization to membrane • protein targeting • localization within membrane • protein localization to membrane • protein targeting to membrane • cellular macromolecule localization • macromolecule localization • renal system process • regulation of renal system process • regulation of blood pressure • regulation of system process • regulation of glomerular filtration • regulation of systemic arterial blood pressure • circulatory system process • renal system process involved in regulation of blood volume • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • glomerular filtration • blood circulation • renal filtration • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • positive regulation of potassium ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • nervous system development • negative regulation of signaling • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • negative regulation of synaptic transmission, glutamatergic • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • circadian sleep/wake cycle, non-REM sleep • regulation of behavior • sleep • circadian sleep/wake cycle, sleep • rhythmic process • negative regulation of behavior • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of circadian rhythm • negative regulation of circadian sleep/wake cycle, non-REM sleep • behavior • circadian behavior • regulation of circadian sleep/wake cycle, sleep • negative regulation of multicellular organismal process • circadian sleep/wake cycle process • negative regulation of locomotion • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • negative regulation of leukocyte migration • negative regulation of immune system process • immune system process • regulation of cell migration • negative regulation of cell motility • cell migration • regulation of immune system process • cell motility • negative regulation of cell migration • inorganic ion homeostasis • intracellular calcium ion homeostasis • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • negative regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • positive regulation of phosphorus metabolic process • positive regulation of dephosphorylation • regulation of dephosphorylation • dephosphorylation • positive regulation of phosphate metabolic process • positive regulation of metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • phosphorus metabolic process • negative regulation of neurotrophin production • neurotrophin production • regulation of neurotrophin production • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • actin filament-based process • cardiac muscle cell contraction • regulation of cardiac muscle contraction • actin filament-based movement • muscle contraction • muscle system process • regulation of muscle system process • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of muscle contraction • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • respiratory gaseous exchange by respiratory system • respiratory system process • regulation of respiratory gaseous exchange • regulation of respiratory system process • regulation of respiratory gaseous exchange by nervous system process • regulation of nervous system process • regulation of sensory perception • regulation of sensory perception of pain • positive regulation of peptide secretion • regulation of peptide secretion • regulation of peptide transport • regulation of secretion • peptide transport • peptide secretion • positive regulation of secretion • amide transport • negative regulation of amino acid transport • negative regulation of amine transport • regulation of glutamate secretion • negative regulation of transport • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of glutamate secretion • regulation of amino acid transport • glutamate secretion • negative regulation of secretion by cell • organic anion transport • carboxylic acid transport • export from cell • organic acid transport • amino acid transport • amine transport • acidic amino acid transport • negative regulation of organic acid transport • regulation of organic acid transport • dicarboxylic acid transport • regulation of amine transport • positive regulation of catabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • regulation of hormone secretion • hormone secretion • signal release • negative regulation of hormone secretion • regulation of hormone levels • hormone transport • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • excitatory postsynaptic potential • regulation of membrane potential • regulation of mucus secretion • negative regulation of mucus secretion • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • fatty acid homeostasis • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of defense response • negative regulation of acute inflammatory response • regulation of response to external stimulus • defense response • negative regulation of inflammatory response • negative regulation of response to stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • regulation of acute inflammatory response • inflammatory response • acute inflammatory response • negative regulation of long-term synaptic depression • long-term synaptic depression • regulation of long-term synaptic depression • apoptotic signaling pathway • multicellular organismal-level homeostasis • temperature homeostasis • negative regulation of systemic arterial blood pressure • negative regulation of blood pressure • response to purine-containing compound • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic active zone • presynaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • axon • axon terminus • distal axon • calyx of Held • neuron projection terminus • neuron spine • dendritic spine • cell leading edge • axolemma • leading edge membrane • neuron projection membrane • main axon • cell projection membrane • neuronal cell body • terminal bouton • asymmetric synapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	Adenosine
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30542
Sequence	>7LD4_nogp_Chain_R I S A F Q A A Y I G I E V L I A L V S V P G N V L V I W A V K V N Q A L R D A T F C F I V S L A V A D V A V G A L V I P L A I L I N I G P Q T Y F H T C L M V A C P V L I L T Q S S I L A L L A I A V D R Y L R V K I P L R Y K M V V T P R R A A V A I A G C W I L S F V V G L T P M F G W N N L S A V E R A W A A N G S M G E P V I K C E F E K V I S M E Y M V Y F N F F V W V L P P L L L M V L I Y L E V F Y L I R K Q L N K K Y Y G K E L K I A K S L A L I L F L F A L S W L P L H I L N C I T L F C P S C H K P S I L T Y I A I F L T H G N S A M N P I V Y A F R I Q K F R V T F L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	10.1038/s41586-025-08618-7
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA	Gi1/β1/γ2	3.2	2024-12-11	10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA		3.2	2024-12-11	10.1016/j.celrep.2024.115024
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	10.1038/s41467-024-54206-0
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	10.1038/s41467-024-54206-0
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8Y52	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-09-11	10.1016/j.celrep.2024.114511
	8Y52 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-		2.9	2024-09-11	10.1016/j.celrep.2024.114511
	8ZMF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	A1L10	-	-	3.6	2024-08-28	10.1021/acs.jmedchem.4c01244
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8IEP	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.61	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEI	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.62	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEB	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	3.03	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	Go/β1/γ2	3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-		3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.39	2024-01-24	10.1126/sciadv.adj2384
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	10.1073/pnas.2219569120
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	10.1073/pnas.2219569120
	7LD4	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-	Gi2/β1/γ2	3.3	2021-09-08	10.1038/s41586-021-03897-2
	7LD4 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-		3.3	2021-09-08	10.1038/s41586-021-03897-2
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603	Gi2/β1/γ2	3.2	2021-09-08	10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603		3.2	2021-09-08	10.1038/s41586-021-03897-2
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	10.1074/jbc.RA120.013793
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OFJ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.5	2019-08-21	10.1074/jbc.RA119.010089
	6D9H	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-	Gi2/β1/γ2	3.6	2018-06-20	10.1038/s41586-018-0236-6
	6D9H (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-		3.6	2018-06-20	10.1038/s41586-018-0236-6
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	10.1038/s41467-017-01240-w
	5N2S	A	Nucleotide	Adenosine	A₁	Homo sapiens	PSB36	-	-	3.3	2017-07-26	10.1016/j.str.2017.06.012
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; PubChem 127053597	-	3.22	2017-06-07	10.1038/nsmb.3417
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	10.1038/nsmb.3417
	5UEN	A	Nucleotide	Adenosine	A₁	Homo sapiens	DU172	-	-	3.2	2017-03-01	10.1016/j.cell.2017.01.042
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	10.1038/nature13494

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7LD4_nogp.zip

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