Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 8.294500
2R:R:N62 4.295408
3R:R:Y67 6.40167608
4R:R:K82 6.7425404
5R:R:R85 4.345401
6R:R:F86 8.64504
7R:R:F107 7.962523
8R:R:Y110 6.24667628
9R:R:L111 6.365405
10R:R:E123 10.5275439
11R:R:F130 2.685405
12R:R:W133 5.1975437
13R:R:Y134 9.69637
14R:R:R138 9.82639
15R:R:W151 3.072509
16R:R:Y179 7.155625
17R:R:F183 7.05526
18R:R:F224 9.3025419
19R:R:L225 3.3225407
20R:R:L235 6.154523
21R:R:R239 6.35857723
22R:R:F247 6.8025402
23R:R:P266 4.815409
24R:R:Y269 8.64833619
25R:R:M272 8.4418
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:L254 59.82374.16YesNo005
2R:R:F247 R:R:L254 58.89768.53YesNo025
3R:R:F247 R:R:L251 51.09654.87YesNo023
4R:R:H255 R:R:L251 48.710910.29NoNo033
5R:R:H255 R:R:S258 47.49595.58NoNo038
6R:R:K82 R:R:S258 46.21433.06YesNo048
7R:R:F86 R:R:K82 37.420413.65YesYes044
8R:R:F86 R:R:S41 16.15795.28YesNo046
9R:R:A259 R:R:S41 11.60913.42NoNo046
10L:L:?1 R:R:Y110 64.868915.85YesYes008
11R:R:F183 R:R:Y110 57.03814.13YesYes268
12R:R:F183 R:R:L114 97.02187.31YesNo068
13R:R:F187 R:R:L114 98.08866.09NoNo068
14R:R:C191 R:R:F187 98.31834.19NoNo056
15R:R:C191 R:R:L225 98.53314.76NoYes057
16R:R:L190 R:R:L225 99.9634.15NoYes087
17R:R:L117 R:R:L190 1004.15NoNo098
18R:R:L117 R:R:L71 39.00584.15NoNo099
19R:R:L71 R:R:Y269 29.80448.21NoYes099
20R:R:A72 R:R:Y269 21.18092.67NoYes099
21R:R:A72 R:R:G73 19.63991.95NoNo096
22R:R:D75 R:R:Y269 12.92786.9NoYes199
23R:R:D75 R:R:N48 11.71285.39NoNo099
24R:R:N48 R:R:P266 10.08311.4NoYes099
25R:R:G73 R:R:I52 13.25381.76NoNo068
26R:R:I52 R:R:W53 10.12745.87NoNo086
27R:R:F224 R:R:L117 63.40944.87YesNo099
28R:R:F224 R:R:M272 23.692416.17YesYes198
29R:R:F224 R:R:V120 64.55776.55YesNo199
30R:R:V120 R:R:Y67 67.21743.79NoYes098
31R:R:E123 R:R:Y67 46.747712.35YesYes098
32R:R:E123 R:R:F64 10.62383.5YesNo398
33R:R:E123 R:R:Y134 17.032213.47YesYes397
34R:R:E123 R:R:R138 18.173112.79YesYes399
35R:R:S143 R:R:Y67 20.44758.9NoYes098
36R:R:R138 R:R:S143 19.84745.27YesNo099
37R:R:L116 R:R:L71 15.78015.54NoNo079
38R:R:L116 R:R:W151 14.00213.42NoYes079
39R:R:F86 R:R:R85 17.49896.41YesYes041
40R:R:Y110 R:R:Y179 11.59433.97YesYes285
41R:R:R239 R:R:Y179 18.07684.12YesYes235
42R:R:F183 R:R:L235 16.35814.61YesYes263
43R:R:L111 R:R:Y179 14.28369.38YesYes055
44R:R:L225 R:R:S194 14.79483YesNo077
45R:R:L197 R:R:R124 10.17934.86NoNo089
46R:R:W133 R:R:Y134 14.57255.79YesYes377
47R:R:F130 R:R:W133 21.47732YesYes057
48R:R:R138 R:R:W133 28.233810YesYes397
49R:R:R137 R:R:W133 17.38783NoYes067
50R:R:I132 R:R:R137 13.06123.76NoNo076
51R:R:N176 R:R:R239 10.386714.46NoYes043
52R:R:L240 R:R:R239 13.10561.21NoYes033
53R:R:M272 R:R:Y269 14.59488.38YesYes189
54R:R:F183 R:R:Y179 25.38156.19YesYes265
55R:R:L235 R:R:R239 12.35744.86YesYes233
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y110 15.85 0 Yes Yes 0 8 0 1
L:L:?1 R:R:G234 12.85 0 Yes No 0 3 0 1
L:L:?1 R:R:L254 4.16 0 Yes No 0 5 0 1
L:L:?1 R:R:L257 6.24 0 Yes No 0 7 0 1
R:R:T106 R:R:Y110 3.75 0 No Yes 4 8 2 1
R:R:S109 R:R:Y110 5.09 0 No Yes 6 8 2 1
R:R:Y110 R:R:Y179 3.97 2 Yes Yes 8 5 1 2
R:R:F183 R:R:Y110 4.13 2 Yes Yes 6 8 2 1
R:R:L231 R:R:Y110 4.69 0 No Yes 5 8 2 1
R:R:F183 R:R:Y179 6.19 2 Yes Yes 6 5 2 2
R:R:F247 R:R:L254 8.53 0 Yes No 2 5 2 1
L:L:?1 R:R:A237 2.37 0 Yes No 0 5 0 1
R:R:A233 R:R:G234 1.95 0 No No 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9UST_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.06
Number of Linked Nodes 209
Number of Links 224
Number of Hubs 25
Number of Links mediated by Hubs 99
Number of Communities 4
Number of Nodes involved in Communities 25
Number of Links involved in Communities 36
Path Summary
Number Of Nodes in MetaPath 56
Number Of Links MetaPath 55
Number of Shortest Paths 25189
Length Of Smallest Path 3
Average Path Length 14.2765
Length of Longest Path 33
Minimum Path Strength 1.425
Average Path Strength 6.03537
Maximum Path Strength 23.055
Minimum Path Correlation 0.7
Average Path Correlation 0.922391
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 44.1177
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.5506
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeA1D
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtA0A9L0JPP9
Sequence
>9UST_nogp_Chain_R
LFLAVLSLC GLVGNGTVI WLLGFRIKR NPFSVYILN LAGADFAFL 
FCKSVRFLL LNRSVAVLN VLIRGVTFS SYLGGLSLL MAVSVERCL 
SVLFPIWYR CRRAQLSAI ACALIWGLS LCGILVFLC VHFVDFCDV 
VNLVYGMFF LTFLVLCAS SLLIVQCFR IVLLTVLAF LVLGLPLGA 
GLLDRLSPS LPFDILLPI LHLLSALNS GVNPLIYFF MGRTTVLVL 
MLNALWAC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YFSAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ22.82025-03-05To be published
8YFS (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-2.82025-03-05To be published
9USTAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ23.022025-07-02To be published
9UST (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-3.022025-07-02To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9UST_nogp.zip



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