psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F78	13.96	Yes	Yes	0	0	6
2	L:L:?1	R:R:S109	5.16	Yes	No	0	0	6
3	L:L:?1	R:R:Y110	28.22	Yes	Yes	1	0	8
4	L:L:?1	R:R:P230	3.76	Yes	Yes	1	0	9
5	L:L:?1	R:R:G234	7.84	Yes	Yes	1	0	3
6	L:L:?1	R:R:N261	15.74	Yes	No	1	0	9
7	R:R:L33	R:R:P252	6.57	No	No	0	5	2
8	R:R:I253	R:R:L33	9.99	No	No	0	4	5
9	R:R:L256	R:R:T37	8.84	No	Yes	0	5	4
10	R:R:L39	R:R:L42	6.92	No	No	0	4	5
11	R:R:L256	R:R:V40	4.47	No	No	0	5	7
12	R:R:A259	R:R:V40	3.39	No	No	0	4	7
13	R:R:L45	R:R:S83	3	No	No	0	6	5
14	R:R:G47	R:R:T50	3.64	No	No	0	8	5
15	R:R:G47	R:R:P266	4.06	No	Yes	0	8	9
16	R:R:N48	R:R:V51	2.96	Yes	No	2	9	9
17	R:R:A72	R:R:N48	3.13	No	Yes	0	9	9
18	R:R:D75	R:R:N48	8.08	No	Yes	2	9	9
19	R:R:N48	R:R:P266	3.26	Yes	Yes	2	9	9
20	R:R:G49	R:R:W53	5.63	No	No	0	7	6
21	R:R:T50	R:R:W53	3.64	No	No	0	5	6
22	R:R:L54	R:R:T50	2.95	No	No	0	7	5
23	R:R:P266	R:R:V51	3.53	Yes	No	2	9	9
24	R:R:V51	R:R:Y269	5.05	No	No	0	9	9
25	R:R:I52	R:R:W53	3.52	No	No	0	8	6
26	R:R:I52	R:R:L69	5.71	No	No	0	8	7
27	R:R:F270	R:R:L54	4.87	No	No	0	8	7
28	R:R:I59	R:R:L55	4.28	No	No	0	8	8
29	R:R:N62	R:R:S65	10.43	No	No	0	8	8
30	R:R:P63	R:R:Y134	8.34	Yes	Yes	3	7	7
31	R:R:P63	R:R:R138	8.65	Yes	Yes	3	7	9
32	R:R:P63	R:R:S143	3.56	Yes	No	0	7	9
33	R:R:E123	R:R:F64	7	Yes	No	3	9	8
34	R:R:F64	R:R:Y134	7.22	No	Yes	3	8	7
35	R:R:S143	R:R:V66	9.7	No	No	0	9	8
36	R:R:L116	R:R:Y67	4.69	No	Yes	0	7	8
37	R:R:A119	R:R:Y67	5.34	No	Yes	0	8	8
38	R:R:V120	R:R:Y67	5.05	No	Yes	0	9	8
39	R:R:E123	R:R:Y67	15.71	Yes	Yes	0	9	8
40	R:R:S143	R:R:Y67	5.09	No	Yes	0	9	8
41	R:R:A146	R:R:Y67	4	No	Yes	0	7	8
42	R:R:F224	R:R:I68	5.02	Yes	No	0	9	8
43	R:R:L116	R:R:N70	8.24	No	No	0	7	9
44	R:R:C147	R:R:N70	6.3	No	No	0	8	9
45	R:R:N70	R:R:W151	7.91	No	Yes	0	9	9
46	R:R:L116	R:R:L71	5.54	No	No	0	7	9
47	R:R:L117	R:R:L71	5.54	No	No	0	9	9
48	R:R:L71	R:R:Y269	12.89	No	No	0	9	9
49	R:R:D75	R:R:L79	9.5	No	No	2	9	8
50	R:R:D75	R:R:S262	7.36	No	No	2	9	9
51	R:R:F78	R:R:L79	3.65	Yes	No	0	6	8
52	R:R:F78	R:R:K82	11.17	Yes	Yes	0	6	4
53	R:R:F78	R:R:T106	3.89	Yes	No	0	6	4
54	R:R:L79	R:R:S262	9.01	No	No	2	8	9
55	R:R:F80	R:R:S83	5.28	No	No	0	5	5
56	R:R:C81	R:R:I102	3.27	No	No	0	4	4
57	R:R:K82	R:R:R85	3.71	Yes	No	0	4	1
58	R:R:F86	R:R:K82	6.2	No	Yes	0	4	4
59	R:R:I102	R:R:K82	5.82	No	Yes	0	4	4
60	R:R:L88	R:R:V84	2.98	No	No	0	3	5
61	R:R:L98	R:R:V84	2.98	No	No	0	4	5
62	R:R:N99	R:R:R85	4.82	No	No	0	3	1
63	R:R:H255	R:R:R85	3.39	No	No	0	3	1
64	R:R:L88	R:R:S94	12.01	No	No	0	3	2
65	R:R:V95	R:R:V97	3.21	No	No	0	3	1
66	R:R:V100	R:R:V97	3.21	No	No	0	3	1
67	R:R:L101	R:R:V105	2.98	No	No	0	4	4
68	R:R:F162	R:R:R103	5.34	No	No	0	4	3
69	R:R:R103	R:R:V165	3.92	No	No	0	3	1
70	R:R:H166	R:R:R103	4.51	No	No	0	2	3
71	R:R:F162	R:R:G104	7.53	No	No	0	4	3
72	R:R:T106	R:R:Y110	6.24	No	Yes	0	4	8
73	R:R:F107	R:R:V161	5.24	Yes	Yes	1	3	3
74	R:R:F107	R:R:Y179	11.35	Yes	Yes	1	3	5
75	R:R:D238	R:R:F107	10.75	No	Yes	1	2	3
76	R:R:F107	R:R:R239	11.76	Yes	Yes	1	3	3
77	R:R:S108	R:R:W151	3.71	Yes	Yes	5	4	9
78	R:R:S108	R:R:S154	4.89	Yes	Yes	5	4	8
79	R:R:L155	R:R:S108	4.5	No	Yes	0	4	4
80	R:R:Y110	R:R:Y179	2.98	Yes	Yes	1	8	5
81	R:R:G234	R:R:Y110	4.35	Yes	Yes	1	3	8
82	R:R:L235	R:R:Y110	4.69	Yes	Yes	1	3	8
83	R:R:L111	R:R:S115	3	No	Yes	0	5	7
84	R:R:L111	R:R:S154	4.5	No	Yes	0	5	8
85	R:R:F183	R:R:L111	3.65	Yes	No	0	6	5
86	R:R:G112	R:R:S115	3.71	No	Yes	0	7	7
87	R:R:G112	R:R:S154	3.71	No	Yes	0	7	8
88	R:R:F183	R:R:L114	13.4	Yes	No	0	6	8
89	R:R:L114	R:R:T186	5.9	No	No	0	8	8
90	R:R:F187	R:R:L114	4.87	No	No	0	6	8
91	R:R:I150	R:R:S115	6.19	No	Yes	0	7	7
92	R:R:S115	R:R:T186	4.8	Yes	No	0	7	8
93	R:R:M118	R:R:T186	3.01	No	No	0	8	8
94	R:R:M118	R:R:V189	4.56	No	No	0	8	5
95	R:R:F224	R:R:V120	6.55	Yes	No	0	9	9
96	R:R:S121	R:R:S193	4.89	No	No	0	9	8
97	R:R:L126	R:R:V122	2.98	No	No	0	6	6
98	R:R:S193	R:R:V122	4.85	No	No	0	8	6
99	R:R:E123	R:R:Y134	12.35	Yes	Yes	3	9	7
100	R:R:E123	R:R:R138	10.47	Yes	Yes	3	9	9
101	R:R:L197	R:R:R124	3.64	Yes	No	4	8	9
102	R:R:F224	R:R:R124	8.55	Yes	No	4	9	9
103	R:R:M272	R:R:R124	9.93	No	No	4	8	9
104	R:R:C125	R:R:S193	3.44	No	No	0	8	8
105	R:R:L126	R:R:W133	3.42	No	Yes	0	6	7
106	R:R:S127	R:R:V128	4.85	No	No	0	8	8
107	R:R:L197	R:R:V128	2.98	Yes	No	4	8	8
108	R:R:V128	R:R:W200	13.48	No	Yes	4	8	6
109	R:R:F130	R:R:L129	7.31	No	No	0	5	5
110	R:R:I132	R:R:R137	3.76	No	No	0	7	6
111	R:R:W133	R:R:Y134	6.75	Yes	Yes	3	7	7
112	R:R:R137	R:R:W133	4	No	Yes	0	6	7
113	R:R:R138	R:R:W133	11	Yes	Yes	3	9	7
114	R:R:R138	R:R:Y134	18.52	Yes	Yes	3	9	7
115	R:R:L142	R:R:R138	7.29	No	Yes	0	6	9
116	R:R:L149	R:R:L153	4.15	No	No	0	5	6
117	R:R:S154	R:R:W151	4.94	Yes	Yes	5	8	9
118	R:R:I159	R:R:L155	5.71	No	No	0	4	4
119	R:R:M157	R:R:Y179	7.18	No	Yes	0	5	5
120	R:R:N176	R:R:V161	2.96	No	Yes	1	4	3
121	R:R:R239	R:R:V161	3.92	Yes	Yes	1	3	3
122	R:R:C164	R:R:C172	7.28	No	No	0	5	8
123	R:R:L171	R:R:V168	2.98	No	No	0	1	1
124	R:R:C172	R:R:V168	3.42	No	No	0	8	1
125	R:R:C172	R:R:V175	3.42	No	No	0	8	3
126	R:R:N176	R:R:R239	15.67	No	Yes	1	4	3
127	R:R:L235	R:R:Y179	7.03	Yes	Yes	1	3	5
128	R:R:R239	R:R:Y179	7.2	Yes	Yes	1	3	5
129	R:R:N180	R:R:R239	6.03	No	Yes	0	4	3
130	R:R:F183	R:R:G232	3.01	Yes	No	0	6	6
131	R:R:F183	R:R:L235	15.83	Yes	Yes	0	6	3
132	R:R:L190	R:R:L225	4.15	No	No	0	8	7
133	R:R:L225	R:R:S194	3	No	No	0	7	7
134	R:R:L197	R:R:W200	3.42	Yes	Yes	4	8	6
135	R:R:L197	R:R:V221	4.47	Yes	No	0	8	8
136	R:R:L198	R:R:V221	7.45	No	No	0	5	8
137	R:R:V201	R:R:W200	3.68	No	Yes	0	7	6
138	R:R:F204	R:R:W200	11.02	No	Yes	0	6	6
139	R:R:F271	R:R:T220	6.49	No	No	0	7	8
140	R:R:A223	R:R:M272	6.44	No	No	0	6	8
141	R:R:F224	R:R:M272	28.61	Yes	No	4	9	8
142	R:R:L229	R:R:V226	2.98	No	No	0	5	5
143	R:R:I268	R:R:L227	7.14	No	No	0	8	6
144	R:R:L229	R:R:P230	4.93	No	Yes	0	5	9
145	R:R:N261	R:R:P230	9.77	No	Yes	1	9	9
146	R:R:D238	R:R:R239	8.34	No	Yes	1	2	3
147	R:R:L240	R:R:S243	6.01	No	No	0	3	1
148	R:R:P242	R:R:S241	3.56	No	No	0	1	1
149	R:R:L244	R:R:S243	9.01	No	No	0	1	1
150	R:R:F247	R:R:L250	9.74	No	No	0	2	3
151	R:R:I253	R:R:L250	5.71	No	No	0	4	3
152	R:R:L254	R:R:L257	4.15	No	No	0	5	7
153	R:R:H255	R:R:S258	4.18	No	No	0	3	8
154	R:R:L267	R:R:V264	4.47	No	No	0	6	8
155	R:R:N265	R:R:Y269	12.79	No	No	0	9	9
156	R:R:F271	R:R:I268	5.02	No	No	0	7	8
157	R:R:M157	R:R:M182	2.89	No	No	0	5	6
158	R:R:I102	R:R:L98	2.85	No	No	0	4	4
159	R:R:C136	R:R:R135	2.79	No	No	0	7	8
160	R:R:C191	R:R:F187	2.79	No	No	0	5	6
161	R:R:C246	R:R:F247	2.79	No	No	0	1	2
162	R:R:L87	R:R:L88	2.77	No	No	0	4	3
163	R:R:L87	R:R:L91	2.77	No	No	0	4	2
164	R:R:L101	R:R:L98	2.77	No	No	0	4	4
165	R:R:L117	R:R:L190	2.77	No	No	0	9	8
166	R:R:L198	R:R:L222	2.77	No	No	6	5	6
167	R:R:L251	R:R:L254	2.77	No	No	0	3	5
168	R:R:I145	R:R:Q141	2.74	No	No	0	5	5
169	R:R:F86	R:R:V38	2.62	No	No	0	4	4
170	R:R:F162	R:R:V100	2.62	No	No	0	4	3
171	R:R:F34	R:R:T37	2.59	No	Yes	0	3	4
172	R:R:F86	R:R:T37	2.59	No	Yes	0	4	4
173	R:R:A74	R:R:W151	2.59	No	Yes	0	9	9
174	R:R:F76	R:R:L45	2.44	No	No	0	6	6
175	R:R:F130	R:R:L126	2.44	No	No	0	5	6
176	R:R:F271	R:R:L219	2.44	No	No	0	7	7
177	R:R:F224	R:R:L227	2.44	Yes	No	0	9	6
178	R:R:F247	R:R:L251	2.44	No	No	0	2	3
179	R:R:L91	R:R:R93	2.43	No	No	0	2	1
180	R:R:F76	R:R:N48	2.42	No	Yes	0	6	9
181	R:R:F270	R:R:R274	2.14	No	No	0	8	7
182	R:R:G263	R:R:G44	2.11	No	No	0	8	9
183	R:R:G112	R:R:G113	2.11	No	No	0	7	8
184	R:R:G44	R:R:P266	2.03	No	Yes	0	9	9
185	R:R:G228	R:R:P230	2.03	No	Yes	0	7	9
186	R:R:C43	R:R:G44	1.96	No	No	0	5	9
187	R:R:A233	R:R:G234	1.95	No	Yes	0	6	3
188	R:R:A237	R:R:G234	1.95	No	Yes	0	5	3
189	R:R:G158	R:R:S108	1.86	No	Yes	0	6	4
190	R:R:G47	R:R:V46	1.84	No	No	0	8	5
191	R:R:A196	R:R:C125	1.81	No	No	0	6	8
192	R:R:A144	R:R:C147	1.81	No	No	0	5	8
193	R:R:A259	R:R:S41	1.71	No	No	0	4	6
194	R:R:G113	R:R:L231	1.71	No	No	0	8	5
195	R:R:G152	R:R:L153	1.71	No	No	0	5	6
196	R:R:A36	R:R:V40	1.7	No	No	0	5	7
197	R:R:C136	R:R:I132	1.64	No	No	0	7	7
198	R:R:L244	R:R:P245	1.64	No	No	0	1	1
199	R:R:N62	R:R:P63	1.63	No	Yes	0	8	7
200	R:R:V161	R:R:V165	1.6	Yes	No	0	3	1
201	R:R:C43	R:R:L42	1.59	No	No	0	5	5
202	R:R:C191	R:R:L195	1.59	No	No	0	5	6
203	R:R:T220	R:R:V217	1.59	No	No	0	8	8
204	R:R:A192	R:R:L188	1.58	No	No	0	5	6
205	R:R:M182	R:R:V178	1.52	No	No	0	6	6
206	R:R:F76	R:R:G73	1.51	No	No	0	6	6
207	R:R:L55	R:R:S65	1.5	No	No	0	8	8
208	R:R:L160	R:R:V175	1.49	No	No	0	6	3
209	R:R:L260	R:R:V264	1.49	No	No	0	5	8
210	R:R:L33	R:R:T37	1.47	No	Yes	0	5	4
211	R:R:I249	R:R:I253	1.47	No	No	0	3	4
212	R:R:F130	R:R:P131	1.44	No	No	0	5	9
213	R:R:L139	R:R:L142	1.38	No	No	0	8	6
214	R:R:L198	R:R:L218	1.38	No	No	6	5	6
215	R:R:L218	R:R:L222	1.38	No	No	6	6	6
216	R:R:L235	R:R:L236	1.38	Yes	No	0	3	5
217	R:R:L256	R:R:L260	1.38	No	No	0	5	5
218	R:R:L257	R:R:L260	1.38	No	No	0	7	5
219	R:R:L177	R:R:N176	1.37	No	No	0	3	4
220	R:R:D173	R:R:L177	1.36	No	No	0	3	3
221	R:R:D248	R:R:L251	1.36	No	No	0	1	3
222	R:R:R61	R:R:S65	1.32	No	No	0	8	8
223	R:R:F167	R:R:V168	1.31	No	No	0	2	1
224	R:R:F34	R:R:L89	1.22	No	No	0	3	1
225	R:R:F167	R:R:L163	1.22	No	No	0	2	3
226	R:R:F184	R:R:L188	1.22	No	No	0	5	6
227	R:R:L240	R:R:R239	1.21	No	Yes	0	3	3
228	R:R:D169	R:R:F170	1.19	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.4467	6	1	0
2	R:R:T37	3.8725	4	0	4
3	R:R:N48	3.97	5	2	9
4	R:R:P63	5.545	4	3	7
5	R:R:Y67	6.64667	6	0	8
6	R:R:F78	8.1675	4	0	6
7	R:R:K82	6.725	4	0	4
8	R:R:F107	9.775	4	1	3
9	R:R:S108	3.74	4	5	4
10	R:R:Y110	9.296	5	1	8
11	R:R:S115	4.425	4	0	7
12	R:R:E123	11.3825	4	3	9
13	R:R:W133	6.2925	4	3	7
14	R:R:Y134	10.636	5	3	7
15	R:R:R138	11.186	5	3	9
16	R:R:W151	4.7875	4	5	9
17	R:R:S154	4.51	4	5	8
18	R:R:V161	3.43	4	1	3
19	R:R:Y179	7.148	5	1	5
20	R:R:F183	8.9725	4	0	6
21	R:R:L197	3.6275	4	4	8
22	R:R:W200	7.9	4	4	6
23	R:R:F224	10.234	5	4	9
24	R:R:P230	5.1225	4	1	9
25	R:R:G234	4.0225	4	1	3
26	R:R:L235	7.2325	4	1	3
27	R:R:R239	7.73286	7	1	3
28	R:R:P266	3.22	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F78	49.3464	13.96	Yes	Yes	0	0	6
2	R:R:F78	R:R:K82	93.9093	11.17	Yes	Yes	0	6	4
3	R:R:F86	R:R:K82	62.7515	6.2	No	Yes	0	4	4
4	R:R:F86	R:R:T37	58.6169	2.59	No	Yes	0	4	4
5	R:R:L33	R:R:T37	22.8701	1.47	No	Yes	0	5	4
6	R:R:I253	R:R:L33	17.8641	9.99	No	No	0	4	5
7	R:R:L256	R:R:T37	30.3235	8.84	No	Yes	0	5	4
8	R:R:F78	R:R:L79	74.4693	3.65	Yes	No	0	6	8
9	R:R:D75	R:R:L79	72.2722	9.5	No	No	2	9	8
10	R:R:D75	R:R:N48	72.7635	8.08	No	Yes	2	9	9
11	R:R:N48	R:R:P266	23.1297	3.26	Yes	Yes	2	9	9
12	R:R:G44	R:R:P266	12.3667	2.03	No	Yes	0	9	9
13	R:R:L256	R:R:V40	10.559	4.47	No	No	0	5	7
14	R:R:F76	R:R:N48	12.1164	2.42	No	Yes	0	6	9
15	R:R:G47	R:R:P266	24.2792	4.06	No	Yes	0	8	9
16	R:R:G47	R:R:T50	19.5699	3.64	No	No	0	8	5
17	R:R:N48	R:R:V51	46.7322	2.96	Yes	No	2	9	9
18	R:R:V51	R:R:Y269	60.9994	5.05	No	No	0	9	9
19	R:R:L71	R:R:Y269	60.0723	12.89	No	No	0	9	9
20	R:R:L116	R:R:L71	62.3899	5.54	No	No	0	7	9
21	R:R:L116	R:R:Y67	100	4.69	No	Yes	0	7	8
22	R:R:S143	R:R:Y67	13.7666	5.09	No	Yes	0	9	8
23	R:R:P63	R:R:S143	11.1616	3.56	Yes	No	0	7	9
24	R:R:N62	R:R:P63	10.5127	1.63	No	Yes	0	8	7
25	L:L:?1	R:R:Y110	46.6673	28.22	Yes	Yes	1	0	8
26	R:R:L235	R:R:Y110	41.3831	4.69	Yes	Yes	1	3	8
27	R:R:F183	R:R:L235	71.8365	15.83	Yes	Yes	0	6	3
28	R:R:F183	R:R:L111	61.2033	3.65	Yes	No	0	6	5
29	R:R:L111	R:R:S154	58.7745	4.5	No	Yes	0	5	8
30	R:R:S154	R:R:W151	56.3456	4.94	Yes	Yes	5	8	9
31	R:R:N70	R:R:W151	59.238	7.91	No	Yes	0	9	9
32	R:R:L116	R:R:N70	58.793	8.24	No	No	0	7	9
33	R:R:E123	R:R:Y67	58.5983	15.71	Yes	Yes	0	9	8
34	R:R:E123	R:R:Y134	26.2075	12.35	Yes	Yes	3	9	7
35	R:R:E123	R:R:R138	29.4799	10.47	Yes	Yes	3	9	9
36	R:R:V120	R:R:Y67	41.105	5.05	No	Yes	0	9	8
37	R:R:F224	R:R:V120	39.3529	6.55	Yes	No	0	9	9
38	R:R:F78	R:R:T106	39.594	3.89	Yes	No	0	6	4
39	R:R:T106	R:R:Y110	39.5105	6.24	No	Yes	0	4	8
40	R:R:I102	R:R:K82	27.2458	5.82	No	Yes	0	4	4
41	R:R:I102	R:R:L98	22.7589	2.85	No	No	0	4	4
42	R:R:L98	R:R:V84	15.426	2.98	No	No	0	4	5
43	R:R:L88	R:R:V84	13.1547	2.98	No	No	0	3	5
44	R:R:Y110	R:R:Y179	48.03	2.98	Yes	Yes	1	8	5
45	R:R:F107	R:R:Y179	26.328	11.35	Yes	Yes	1	3	5
46	R:R:F107	R:R:V161	21.7577	5.24	Yes	Yes	1	3	3
47	R:R:V161	R:R:V165	39.6959	1.6	Yes	No	0	3	1
48	R:R:R103	R:R:V165	34.7455	3.92	No	No	0	3	1
49	R:R:F162	R:R:R103	25.0858	5.34	No	No	0	4	3
50	R:R:F162	R:R:V100	15.1108	2.62	No	No	0	4	3
51	R:R:V100	R:R:V97	10.0955	3.21	No	No	0	3	1
52	R:R:R239	R:R:Y179	45.5085	7.2	Yes	Yes	1	3	5
53	R:R:R239	R:R:V161	21.9153	3.92	Yes	Yes	1	3	3
54	R:R:L111	R:R:S115	11.7642	3	No	Yes	0	5	7
55	R:R:G112	R:R:S154	11.8847	3.71	No	Yes	0	7	8
56	R:R:F183	R:R:L114	15.4909	13.4	Yes	No	0	6	8
57	R:R:W133	R:R:Y134	25.9201	6.75	Yes	Yes	3	7	7
58	R:R:L126	R:R:W133	33.8092	3.42	No	Yes	0	6	7
59	R:R:L126	R:R:V122	18.9395	2.98	No	No	0	6	6
60	R:R:S193	R:R:V122	15.2313	4.85	No	No	0	8	6
61	R:R:R138	R:R:W133	26.0499	11	Yes	Yes	3	9	7
62	R:R:F224	R:R:R124	21.461	8.55	Yes	No	4	9	9
63	R:R:L197	R:R:R124	19.8665	3.64	Yes	No	4	8	9
64	R:R:F130	R:R:L126	11.449	2.44	No	No	0	5	6
65	R:R:R137	R:R:W133	15.2313	4	No	Yes	0	6	7
66	R:R:I132	R:R:R137	11.449	3.76	No	No	0	7	6
67	R:R:F224	R:R:L227	11.8291	2.44	Yes	No	0	9	6
68	L:L:?1	R:R:P230	10.559	3.76	Yes	Yes	1	0	9
69	R:R:L240	R:R:R239	10.3365	1.21	No	Yes	0	3	3
70	R:R:I253	R:R:L250	12.821	5.71	No	No	0	4	3
71	R:R:F247	R:R:L250	10.3087	9.74	No	No	0	2	3
72	R:R:L256	R:R:L260	17.9939	1.38	No	No	0	5	5
73	R:R:L257	R:R:L260	10.457	1.38	No	No	0	7	5
74	R:R:P266	R:R:V51	14.8234	3.53	Yes	No	2	9	9
75	R:R:L235	R:R:Y179	32.0108	7.03	Yes	Yes	1	3	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F78	13.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S109	5.16	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y110	28.22	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:P230	3.76	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G234	7.84	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:N261	15.74	1	Yes	No	0	9	0	1
R:R:F78	R:R:L79	3.65	0	Yes	No	6	8	1	2
R:R:F78	R:R:K82	11.17	0	Yes	Yes	6	4	1	2
R:R:F78	R:R:T106	3.89	0	Yes	No	6	4	1	2
R:R:T106	R:R:Y110	6.24	0	No	Yes	4	8	2	1
R:R:Y110	R:R:Y179	2.98	1	Yes	Yes	8	5	1	2
R:R:G234	R:R:Y110	4.35	1	Yes	Yes	3	8	1	1
R:R:L235	R:R:Y110	4.69	1	Yes	Yes	3	8	2	1
R:R:L235	R:R:Y179	7.03	1	Yes	Yes	3	5	2	2
R:R:L229	R:R:P230	4.93	0	No	Yes	5	9	2	1
R:R:N261	R:R:P230	9.77	1	No	Yes	9	9	1	1
R:R:G228	R:R:P230	2.03	0	No	Yes	7	9	2	1
R:R:A233	R:R:G234	1.95	0	No	Yes	6	3	2	1
R:R:A237	R:R:G234	1.95	0	No	Yes	5	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YFS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	212
Number of Links	228
Number of Hubs	28
Number of Links mediated by Hubs	97
Number of Communities	6
Number of Nodes involved in Communities	36
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	28057
Length Of Smallest Path	3
Average Path Length	12.6423
Length of Longest Path	26
Minimum Path Strength	1.265
Average Path Strength	6.50192
Maximum Path Strength	21.98
Minimum Path Correlation	0.7
Average Path Correlation	0.91592
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	45.0728
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.0403
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A9L0JPP9
Sequence	>8YFS_nogp_Chain_R L F L A V L S L C G L V G N G T V I W L L G R I K R N P F S V Y I L N L A G A D F A F L F C K S V R F L L L N R S V A V L N V L I R G V T F S S Y L G G L S L L M A V S V E R C L S V L F P I W Y R C R R A Q L S A I A C A L I W G L S L C G I L V F L C V H F V D F C D V V N L V Y G M F F L T F L V L C A S S L L I V Q C F R I V L L T V L A F L V L G L P L G A G L L D R L S P S L P F D I L L P I L H L L S A L N S G V N P L I Y F F M G R T T V L V L M L N A L W A C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YFS	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2025-03-05	To be published
	8YFS (No Gprot)	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-		2.8	2025-03-05	To be published
	9UST	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.02	2025-07-02	To be published
	9UST (No Gprot)	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-		3.02	2025-07-02	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YFS_nogp.zip

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