Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.11402
2A:A:N50 7.9575476
3A:A:F212 7.765409
4A:A:V214 5.6775436
5A:A:V217 5.0225435
6A:A:F219 8.34538
7A:A:H220 12.8575417
8A:A:M221 5.83408
9A:A:F222 10.816517
10A:A:Q227 5.92619
11A:A:R231 5.76419
12A:A:K233 7.904519
13A:A:W234 6.29857719
14A:A:C237 4.0925418
15A:A:F238 10.875409
16A:A:D249 11.0975478
17A:A:Y253 6.675408
18A:A:R265 7.806579
19A:A:F273 6.375159
20A:A:W277 8.993336156
21A:A:W281 8.46515
22A:A:L289 4.57409
23A:A:F290 5.418579
24A:A:N292 4.132579
25A:A:K293 8.855479
26A:A:F312 4.298508
27A:A:F315 10.0975406
28A:A:P326 7.0425491
29A:A:D331 9.04494
30A:A:V334 4.238594
31A:A:K338 10.7375495
32A:A:F340 8.4925407
33A:A:F345 7.96408
34A:A:S349 4.13254157
35A:A:R356 8.22402
36A:A:Y360 10.7925408
37A:A:F363 13.675495
38A:A:T364 5.6725479
39A:A:N371 8.106579
40A:A:R373 6.945435
41A:A:F376 6.375438
42A:A:I383 5.37438
43A:A:L384 6.2254166
44A:A:N387 6.28538
45A:A:L388 5.32754168
46A:A:Y391 8.76429734
47B:B:L7 2.5075408
48B:B:I18 4.044547
49B:B:R22 5.736546
50B:B:V40 5.0585113
51B:B:H54 10.55529
52B:B:K57 10.2875419
53B:B:Y59 11.128518
54B:B:M61 5.115426
55B:B:W63 6.615627
56B:B:L70 4.2725425
57B:B:V71 5.188558
58B:B:Q75 10.0025419
59B:B:D76 8.2429
60B:B:L79 4.7225457
61B:B:I80 8.04428
62B:B:I81 4.4557
63B:B:W82 10.8267629
64B:B:N88 6.2825407
65B:B:K89 8.51333629
66B:B:H91 5.605455
67B:B:I93 6.1725457
68B:B:L95 5.704558
69B:B:W99 10619
70B:B:Y105 4.84656
71B:B:N110 8.2754174
72B:B:Y111 6.3545174
73B:B:C114 4.92458
74B:B:L117 3.785419
75B:B:I120 4.6475456
76B:B:C121 3.7375418
77B:B:S122 4.3025458
78B:B:Y124 5.84167656
79B:B:V133 6.1375454
80B:B:E138 4.3875456
81B:B:H142 8.326519
82B:B:Y145 7.12286718
83B:B:L146 3.7175417
84B:B:C148 4.2375466
85B:B:F151 7.015409
86B:B:T159 6.0875419
87B:B:S160 4.7975466
88B:B:D163 10.1125419
89B:B:C166 4.235468
90B:B:W169 9.43714718
91B:B:D170 5.5675409
92B:B:F180 7.396567
93B:B:H183 8.16833669
94B:B:V187 5.318569
95B:B:L190 5.3075465
96B:B:F199 8.06167669
97B:B:V200 9.8625446
98B:B:S201 5.225469
99B:B:D205 6.955469
100B:B:K209 9.925466
101B:B:L210 4.8825405
102B:B:W211 8.19143768
103B:B:D212 5.9325409
104B:B:F222 8.32548
105B:B:H225 8.17125849
106B:B:I229 6.375447
107B:B:I232 5.4775448
108B:B:F235 8.19754136
109B:B:P236 6.37754137
110B:B:F241 9.42546
111B:B:T243 7.0375448
112B:B:D247 7.686549
113B:B:T249 6.016546
114B:B:R251 11.0033648
115B:B:F253 6.93667646
116B:B:D254 7.3525409
117B:B:D258 6.936547
118B:B:Q259 4.6675406
119B:B:Y264 7.6405
120B:B:R283 7.3465119
121B:B:L285 4.21167606
122B:B:Y289 7.686147
123B:B:D290 5.82516
124B:B:C294 5.485485
125B:B:N295 7.43754146
126B:B:V296 3.455405
127B:B:D298 9.41754119
128B:B:L300 4.66254116
129B:B:K301 5.30754115
130B:B:H311 8.362589
131B:B:R314 11.91518
132B:B:M325 6.644525
133B:B:W332 10.73719
134B:B:D333 6.205489
135B:B:L336 5.2875427
136B:B:K337 7.785486
137B:B:W339 9.81689
138B:B:N340 7.4725429
139G:G:R27 7.472548
140G:G:M38 4.754114
141G:G:N59 6.318529
142G:G:P60 8.5775429
143G:G:F61 5.45728
144L:L:?1 7.114500
145R:R:N62 5.064538
146R:R:P63 7.195437
147R:R:F64 8.485438
148R:R:Y67 6.40167608
149R:R:K82 6.7425404
150R:R:R85 4.345401
151R:R:F86 8.64504
152R:R:F107 7.9625123
153R:R:Y110 5.871676128
154R:R:L111 6.365405
155R:R:E123 10.5275439
156R:R:R124 5.8154109
157R:R:I132 4.7325437
158R:R:Y134 8.5725837
159R:R:R135 6.156538
160R:R:R137 2.7625436
161R:R:R138 9.82639
162R:R:W151 3.072509
163R:R:Y179 7.1556125
164R:R:F183 7.055126
165R:R:W200 12.0085166
166R:R:F224 9.30254109
167R:R:L225 3.3225407
168R:R:L235 6.1545123
169R:R:R239 6.358577123
170R:R:F247 6.8025402
171R:R:P266 4.815409
172R:R:Y269 8.648336109
173R:R:M272 8.44108
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:N88 B:B:T86 15.188711.7YesNo076
2B:B:D83 B:B:T86 15.586310.12NoNo086
3B:B:D83 B:B:R68 15.984715.48NoNo085
4B:B:D66 B:B:R68 32.69533.57NoNo085
5B:B:D66 B:B:L69 33.08695.43NoNo085
6B:B:L69 B:B:Y105 33.47835.86NoYes056
7A:A:S23 B:B:N88 10.81125.96NoYes077
8A:A:S23 B:B:K89 10.4146.12NoYes079
9B:B:H62 B:B:Y105 50.52794.36NoYes066
10B:B:H62 B:B:R150 50.911516.93NoNo066
11B:B:C148 B:B:R150 51.29496.96YesNo066
12B:B:C148 B:B:T102 57.02063.38YesNo068
13B:B:C149 B:B:T102 57.24898.45NoNo088
14B:B:C121 B:B:C149 57.82573.64YesNo088
15B:B:C121 B:B:L146 27.6073.17YesYes187
16B:B:H142 B:B:L146 27.98673.86YesYes197
17B:B:H142 B:B:S161 60.202815.34YesNo199
18B:B:G162 B:B:S161 61.34973.71NoNo199
19B:B:G162 B:B:Y145 61.25968.69NoYes198
20B:B:C121 B:B:T159 28.95743.38YesYes189
21B:B:H142 B:B:T159 27.62176.85YesYes199
22A:A:W234 B:B:Y145 59.88363.86YesYes198
23A:A:I235 A:A:W234 65.01643.52NoYes199
24A:A:I235 A:A:L282 63.43495.71NoNo199
25A:A:I244 A:A:L282 99.93515.71NoNo089
26A:A:I244 A:A:V287 1003.07NoNo086
27A:A:F273 A:A:V287 97.94696.55YesNo1596
28A:A:F273 A:A:F345 49.46911.79YesYes098
29A:A:F345 A:A:L270 49.90736.09YesNo086
30A:A:E344 A:A:L270 97.81336.63NoNo056
31A:A:E344 A:A:F340 97.737411.66NoYes057
32A:A:F312 A:A:F340 48.71084.29YesYes087
33A:A:F312 A:A:I308 48.0633.77YesNo087
34A:A:I308 A:A:Y253 95.84398.46NoYes078
35A:A:Y253 A:A:Y311 94.60643.97YesNo086
36A:A:N254 A:A:Y311 94.11016.98NoNo096
37A:A:N254 A:A:R265 93.86173.62NoYes099
38A:A:N50 A:A:R265 91.16986.03YesYes769
39A:A:K293 A:A:N50 89.27925.6YesYes796
40A:A:K293 A:A:N292 87.82884.2YesYes799
41A:A:N292 A:A:T364 85.55764.39YesYes799
42A:A:N371 A:A:T364 76.07448.77YesYes799
43A:A:N371 A:A:Q59 76.288211.88YesNo099
44A:A:M60 A:A:Q59 75.25294.08NoNo099
45A:A:F212 A:A:M60 74.12839.95YesNo099
46A:A:F212 A:A:F219 73.081816.08YesYes098
47A:A:F273 A:A:I348 48.01826.28YesNo094
48A:A:I348 A:A:L270 47.99514.28NoNo046
49A:A:F315 A:A:F340 48.572812.86YesYes067
50A:A:F315 A:A:I308 48.03311.3YesNo067
51A:A:F219 A:A:V217 70.75636.55YesYes385
52A:A:V217 R:R:I132 69.82613.07YesYes357
53A:A:N279 A:A:W281 37.97945.65NoYes185
54A:A:W281 B:B:D290 37.35274.47YesYes156
55A:A:I383 R:R:I132 69.35848.83YesYes387
56A:A:I383 A:A:N387 55.36594.25YesYes388
57A:A:N387 R:R:Y134 52.08053.49YesYes387
58R:R:E123 R:R:Y134 48.623313.47YesYes397
59R:R:E123 R:R:Y67 48.775812.35YesYes098
60R:R:V120 R:R:Y67 44.04363.79NoYes098
61B:B:C148 B:B:L190 22.52043.17YesYes665
62B:B:F199 B:B:L190 19.00416.09YesYes695
63B:B:F199 B:B:W211 12.656115.03YesYes698
64B:B:K209 B:B:T221 11.636712.01YesNo067
65B:B:T221 G:G:E22 12.00498.47NoNo079
66B:B:I18 G:G:E22 20.17084.1YesNo079
67B:B:I18 B:B:R22 17.26555.01YesYes476
68B:B:D258 B:B:R22 12.15198.34YesYes476
69B:B:Q259 B:B:R22 24.80284.67YesYes066
70B:B:D254 B:B:Q259 25.88485.22YesYes096
71B:B:D254 B:B:L261 26.192614.93YesNo095
72B:B:L252 B:B:L261 26.44214.15NoNo075
73B:B:L252 B:B:Y264 22.55588.21NoYes075
74B:B:F278 B:B:L285 15.82348.53NoYes076
75B:B:W297 B:B:Y264 23.89446.75NoYes085
76B:B:N293 B:B:N295 11.61752.72NoYes056
77B:B:N293 B:B:V307 11.20634.43NoNo053
78B:B:G306 B:B:V307 11.00081.84NoNo043
79B:B:G306 B:B:V296 10.79641.84NoYes045
80B:B:R68 B:B:Y85 16.384618.52NoNo054
81B:B:V71 B:B:Y105 11.26395.05YesYes586
82B:B:C271 B:B:D290 38.60946.22NoYes056
83B:B:C271 B:B:Y289 38.20664.03NoYes057
84B:B:W297 B:B:Y289 21.7565.79NoYes1487
85R:R:F224 R:R:V120 43.14496.55YesNo1099
86R:R:F224 R:R:L117 32.82824.87YesNo099
87R:R:L117 R:R:L190 32.66024.15NoNo098
88R:R:L190 R:R:L225 32.37064.15NoYes087
89R:R:C191 R:R:L225 30.95464.76NoYes057
90R:R:C191 R:R:F187 30.66294.19NoNo056
91R:R:F187 R:R:L114 30.3716.09NoNo068
92R:R:F183 R:R:L114 29.20177.31YesNo068
93R:R:F183 R:R:Y110 16.58064.13YesYes1268
94L:L:?1 R:R:Y110 14.941413.6YesYes008
95L:L:?1 R:R:L254 13.43713.57YesNo005
96R:R:F247 R:R:L254 13.13548.53YesNo025
97R:R:F247 R:R:L251 11.01894.87YesNo023
98R:R:H255 R:R:L251 10.412610.29NoNo033
99R:R:H255 R:R:S258 10.10925.58NoNo038
100R:R:F224 R:R:M272 10.409916.17YesYes1098
101A:A:L282 A:A:N279 36.43518.24NoNo198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y110 13.6 0 Yes Yes 0 8 0 1
L:L:?1 R:R:G234 11.02 0 Yes No 0 3 0 1
L:L:?1 R:R:L254 3.57 0 Yes No 0 5 0 1
L:L:?1 R:R:L257 5.35 0 Yes No 0 7 0 1
R:R:T106 R:R:Y110 3.75 0 No Yes 4 8 2 1
R:R:S109 R:R:Y110 5.09 0 No Yes 6 8 2 1
R:R:Y110 R:R:Y179 3.97 12 Yes Yes 8 5 1 2
R:R:F183 R:R:Y110 4.13 12 Yes Yes 6 8 2 1
R:R:L231 R:R:Y110 4.69 0 No Yes 5 8 2 1
R:R:F183 R:R:Y179 6.19 12 Yes Yes 6 5 2 2
R:R:F247 R:R:L254 8.53 0 Yes No 2 5 2 1
L:L:?1 R:R:A237 2.03 0 Yes No 0 5 0 1
R:R:A233 R:R:G234 1.95 0 No No 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
22.22Single8YFSA1D6H8YFS-MRGPRE-A1D6H-chim(NtGi1-Gs-CtGq)/β1/γ2

PDB Summary
PDB 9UST
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRE
Species Equus Quagga
Ligand A1D6H
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.02
Date 2025-07-02
D.O.I. To be published
Net Summary
Imin 3.07
Number of Linked Nodes 807
Number of Links 992
Number of Hubs 173
Number of Links mediated by Hubs 609
Number of Communities 21
Number of Nodes involved in Communities 242
Number of Links involved in Communities 373
Path Summary
Number Of Nodes in MetaPath 102
Number Of Links MetaPath 101
Number of Shortest Paths 1671264
Length Of Smallest Path 3
Average Path Length 38.6431
Length of Longest Path 85
Minimum Path Strength 1.225
Average Path Strength 6.76864
Maximum Path Strength 23.055
Minimum Path Correlation 0.7
Average Path Correlation 0.98297
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.63934
Average % Of Corr. Nodes 37.7528
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.5199
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9UST_Chain_A
EKAEKIEKQ LQKDKQVYR TRLLLLGAS GKSTIVKQM RIHTSGIFE 
TKFQVDKVN FHMFDVGQR DERRKWIQC FNDVTAIIF VVSSYNRLQ 
EALNFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG KSKIEDYFP 
EFARYTTPE DATPEPGED PRVTRAKYF IREFISTAS GDGRHCYPH 
FTCVDTENR RFNDCDIIM LRYLTLSAD AVRSMRLDN YKADDDKVD 
ISAIKLQNE NV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>9UST_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9UST_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtA0A9L0JPP9
Sequence
>9UST_Chain_R
LFLAVLSLC GLVGNGTVI WLLGFRIKR NPFSVYILN LAGADFAFL 
FCKSVRFLL LNRSVAVLN VLIRGVTFS SYLGGLSLL MAVSVERCL 
SVLFPIWYR CRRAQLSAI ACALIWGLS LCGILVFLC VHFVDFCDV 
VNLVYGMFF LTFLVLCAS SLLIVQCFR IVLLTVLAF LVLGLPLGA 
GLLDRLSPS LPFDILLPI LHLLSALNS GVNPLIYFF MGRTTVLVL 
MLNALWAC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YFSAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ22.82025-03-05To be published
8YFS (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-2.82025-03-05To be published
9USTAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ23.022025-07-02To be published
9UST (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-3.022025-07-02To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9UST.zip



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