Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.11402
2A:A:N50 6.26486
3A:A:I207 4.4775419
4A:A:F212 7.4675409
5A:A:V217 4.78754115
6A:A:F219 7.2356118
7A:A:M221 5.5025178
8A:A:F222 8.965417
9A:A:Q227 5.87619
10A:A:R231 7.112519
11A:A:K233 6.325619
12A:A:W234 7.15719
13A:A:I235 4.6225419
14A:A:C237 3.794518
15A:A:F238 9.24509
16A:A:I244 4.084518
17A:A:V248 5.105407
18A:A:D249 8.658588
19A:A:D252 6.745488
20A:A:Y253 6.675408
21A:A:R265 7.386589
22A:A:F273 6.126509
23A:A:W277 12.0525406
24A:A:N278 3.83408
25A:A:W281 9.07667615
26A:A:L282 5.985419
27A:A:I285 4.195417
28A:A:L289 4.875409
29A:A:F290 5.418589
30A:A:L291 4.66508
31A:A:N292 4.3175489
32A:A:K293 7.65589
33A:A:L296 4.2025486
34A:A:F312 4.534508
35A:A:F315 10.4925406
36A:A:P326 5.8875401
37A:A:D331 7.9954194
38A:A:V334 3.46754194
39A:A:F340 8.75407
40A:A:F345 8.265408
41A:A:S349 3.7325407
42A:A:R356 10.255412
43A:A:Y360 11.08408
44A:A:F363 13.014185
45A:A:T364 5.6725489
46A:A:C365 3.19408
47A:A:N371 6.22489
48A:A:F376 4.788336118
49A:A:I383 4.292518
50A:A:M386 7.5525413
51A:A:N387 5.0675418
52A:A:L388 3.5925408
53A:A:R389 6.4425414
54A:A:Y391 8.45167614
55B:B:I18 3.49407
56B:B:L30 3.994525
57B:B:T34 4.105425
58B:B:I37 4.125402
59B:B:V40 6.665423
60B:B:I43 5.2525403
61B:B:H54 8.57649
62B:B:Y59 10.905418
63B:B:M61 4.56546
64B:B:W63 5.57143747
65B:B:L70 3.92445
66B:B:V71 5.188568
67B:B:D76 8.62449
68B:B:L79 4.672567
69B:B:I81 5.065467
70B:B:W82 9.02143749
71B:B:N88 7.0275407
72B:B:K89 6.49167649
73B:B:H91 5.9375405
74B:B:I93 6.1725467
75B:B:L95 5.704568
76B:B:W99 9.83619
77B:B:Y105 4.65143766
78B:B:N110 8.2754154
79B:B:Y111 6.3545154
80B:B:V112 4.7575468
81B:B:C114 4.64468
82B:B:L117 3.598519
83B:B:I120 4.6475466
84B:B:C121 4.135498
85B:B:I123 4.195406
86B:B:Y124 5.56333666
87B:B:L126 4.5575465
88B:B:V133 6.1375464
89B:B:E138 3.805466
90B:B:H142 7.44833699
91B:B:Y145 6.48818
92B:B:L146 4.176597
93B:B:C148 3.89436
94B:B:F151 6.166509
95B:B:I157 5.495497
96B:B:T159 5.722599
97B:B:S160 4.7975436
98B:B:D163 9.42499
99B:B:C166 4.235438
100B:B:W169 9.29857798
101B:B:D170 7.3025409
102B:B:F180 7.396537
103B:B:H183 7.85571739
104B:B:D186 8.24667619
105B:B:V187 5.042539
106B:B:L190 4.935435
107B:B:F199 8.06167639
108B:B:V200 10.19456
109B:B:S201 5.5725439
110B:B:C204 5.83517
111B:B:D205 6.955439
112B:B:K209 10.3436
113B:B:L210 5.215405
114B:B:W211 8.64571738
115B:B:D212 6.23409
116B:B:Q220 6.6525457
117B:B:F222 7.594558
118B:B:H225 8.01375859
119B:B:I229 6.375457
120B:B:I232 5.4775458
121B:B:F235 6.14143726
122B:B:P236 6.7375427
123B:B:F241 8.992556
124B:B:T243 7.0375458
125B:B:D247 8.316559
126B:B:T249 6.274556
127B:B:R251 11.65658
128B:B:F253 6.75833656
129B:B:D254 7.35254209
130B:B:R256 7.0875409
131B:B:Q259 5.4185206
132B:B:M262 5.7575404
133B:B:Y264 6.525405
134B:B:I269 3.97424
135B:B:F278 6.45527
136B:B:S279 4.16254229
137B:B:R283 6.99667629
138B:B:L285 4.01667626
139B:B:Y289 7.70333627
140B:B:D290 4.908516
141B:B:C294 5.4854105
142B:B:N295 6.79526
143B:B:D298 9.4175429
144B:B:L300 4.295426
145B:B:K301 5.3075425
146B:B:H311 8.8665109
147B:B:R314 12.108518
148B:B:L318 4.81406
149B:B:V327 5.5025406
150B:B:T329 4.9345108
151B:B:W332 11.7071719
152B:B:D333 7.53754109
153B:B:L336 4.406547
154B:B:K337 7.135106
155B:B:W339 9.456109
156G:G:L19 5.615409
157G:G:E22 5.3725409
158G:G:R27 5.3408
159G:G:Y40 8.4975426
160G:G:N59 6.8454139
161G:G:P60 8.09754139
162G:G:F61 5.854297138
163L:L:?1 13.9983670
164R:R:T37 3.8725404
165R:R:N48 3.975149
166R:R:P63 8.2675417
167R:R:Y67 6.64667608
168R:R:F78 8.6025406
169R:R:K82 6.725404
170R:R:F107 9.775473
171R:R:S108 3.744164
172R:R:Y110 9.998578
173R:R:G112 3.0854167
174R:R:S115 4.425407
175R:R:E123 11.3825419
176R:R:R124 8.56754129
177R:R:V128 6.07254128
178R:R:I132 3.9075407
179R:R:W133 6.2925417
180R:R:Y134 10.5183617
181R:R:R135 5.42333618
182R:R:R138 11.186519
183R:R:W151 4.3925169
184R:R:S154 4.514168
185R:R:V161 3.43473
186R:R:Y179 7.148575
187R:R:F183 8.9725406
188R:R:L197 3.62754128
189R:R:W200 7.0045126
190R:R:F224 10.2345129
191R:R:P230 5.24479
192R:R:G234 4.2675473
193R:R:L235 7.2325473
194R:R:R239 7.73286773
195R:R:P266 3.224149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:N88 B:B:T86 10.641911.7YesNo076
2B:B:D83 B:B:T86 10.886810.12NoNo086
3B:B:D83 B:B:R68 11.132915.48NoNo085
4B:B:D66 B:B:R68 26.63123.57NoNo085
5B:B:D66 B:B:L69 26.86945.43NoNo085
6B:B:L69 B:B:Y105 27.20455.86NoYes056
7B:B:H62 B:B:Y105 39.65184.36NoYes066
8B:B:H62 B:B:R150 39.874214.67NoNo066
9B:B:C148 B:B:R150 40.09935.57YesNo066
10B:B:C148 B:B:S160 52.5563.44YesYes366
11B:B:S147 B:B:S160 99.82974.89NoYes096
12B:B:S147 B:B:Y145 1002.54NoYes098
13A:A:W234 B:B:Y145 90.02494.82YesYes198
14A:A:F238 A:A:W234 38.80546.01YesYes099
15A:A:I235 A:A:W234 42.94073.52YesYes199
16A:A:I235 A:A:L282 38.44155.71YesYes199
17A:A:I285 A:A:L282 43.13574.28YesYes179
18A:A:I285 A:A:R356 84.8865.01YesYes172
19A:A:M386 A:A:R356 77.720312.41YesYes132
20A:A:I383 A:A:M386 12.88482.92YesYes183
21A:A:F238 A:A:V241 31.13995.24YesNo099
22A:A:I285 A:A:V241 31.18743.07YesNo079
23B:B:M101 B:B:Y145 11.25278.38NoYes198
24B:B:M101 B:B:Y59 11.15933.59NoYes198
25B:B:W332 B:B:Y59 11.468916.4YesYes198
26A:A:I244 A:A:L282 12.16095.71YesYes189
27A:A:I244 A:A:V287 39.55873.07YesNo086
28A:A:F273 A:A:V287 37.27336.55YesNo096
29A:A:F273 A:A:F345 16.451311.79YesYes098
30A:A:E344 A:A:L270 17.24476.63NoNo056
31A:A:E344 A:A:F340 16.887711.66NoYes057
32A:A:N279 A:A:W281 21.47185.65NoYes185
33A:A:L289 A:A:L291 10.43164.15YesYes098
34A:A:F363 A:A:L291 12.72827.31YesYes058
35A:A:W281 B:B:D290 21.71334.47YesYes156
36A:A:M386 R:R:R135 65.77127.44YesYes138
37A:A:Y391 R:R:R135 63.61273.09YesYes148
38A:A:Y391 R:R:P63 20.981212.52YesYes147
39A:A:Y391 R:R:F64 20.477912.38YesNo148
40A:A:Y391 R:R:Y134 21.85439.93YesYes147
41B:B:S160 B:B:V187 42.79994.85YesYes369
42B:B:H183 B:B:V187 36.89816.92YesYes399
43B:B:H183 B:B:S207 16.26382.79YesNo395
44B:B:S207 B:B:T221 16.05823.2NoNo057
45B:B:T221 G:G:E22 33.02858.47NoYes079
46B:B:I18 G:G:E22 11.46224.1YesYes079
47B:B:H183 B:B:K209 17.925813.1YesYes396
48B:B:K209 B:B:T221 17.439113.51YesNo067
49B:B:F199 B:B:L190 10.24536.09YesYes395
50B:B:C271 B:B:D290 22.45133.11NoYes056
51B:B:C271 B:B:Y289 22.06795.38NoYes057
52B:B:W297 B:B:Y289 13.85155.79NoYes287
53B:B:W297 B:B:Y264 13.70624.82NoYes085
54B:B:R68 B:B:Y85 15.326218.52NoNo054
55B:B:Y85 G:G:F61 11.12166.19NoYes1348
56B:B:C148 B:B:T102 16.0723.38YesNo068
57B:B:C149 B:B:T102 15.83248.45NoNo088
58B:B:C121 B:B:C149 15.59653.64YesNo088
59B:B:Q220 G:G:E22 22.6133.82YesYes079
60B:B:F222 B:B:Q220 13.42347.03YesYes587
61B:B:F222 B:B:F253 10.491510.72YesYes586
62R:R:P63 R:R:S143 20.53783.56YesNo079
63R:R:S143 R:R:Y67 20.2695.09NoYes098
64R:R:L116 R:R:Y67 59.69574.69NoYes078
65R:R:L116 R:R:N70 28.28548.24NoNo079
66R:R:N70 R:R:W151 27.20577.91NoYes099
67R:R:S154 R:R:W151 20.59244.94YesYes1689
68R:R:L111 R:R:S154 20.3144.5NoYes058
69R:R:F183 R:R:L111 20.00923.65YesNo065
70R:R:F183 R:R:L235 17.924115.83YesYes063
71R:R:E123 R:R:F64 20.35697YesNo198
72R:R:E123 R:R:Y67 43.068715.71YesYes098
73R:R:E123 R:R:Y134 21.629612.35YesYes197
74R:R:L116 R:R:L71 31.21385.54NoNo079
75R:R:L71 R:R:Y269 29.389412.89NoNo099
76R:R:V51 R:R:Y269 28.67525.05NoNo099
77R:R:N48 R:R:V51 22.42432.96YesNo1499
78R:R:D75 R:R:N48 20.1048.08NoYes1499
79R:R:D75 R:R:L79 19.37669.5NoNo1498
80R:R:F78 R:R:L79 19.03473.65YesNo068
81R:R:F78 R:R:K82 15.966611.17YesYes064
82R:R:L235 R:R:Y179 12.54697.03YesYes735
83A:A:L282 A:A:N279 16.83848.24YesNo198
84A:A:I244 A:A:I285 10.68784.42YesYes187
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F78 15.7 7 Yes Yes 0 6 0 1
L:L:?1 R:R:S109 5.81 7 Yes No 0 6 0 1
L:L:?1 R:R:Y110 31.73 7 Yes Yes 0 8 0 1
L:L:?1 R:R:P230 4.23 7 Yes Yes 0 9 0 1
L:L:?1 R:R:G234 8.82 7 Yes Yes 0 3 0 1
L:L:?1 R:R:N261 17.7 7 Yes No 0 9 0 1
R:R:F78 R:R:L79 3.65 0 Yes No 6 8 1 2
R:R:F78 R:R:K82 11.17 0 Yes Yes 6 4 1 2
R:R:F78 R:R:T106 3.89 0 Yes No 6 4 1 2
R:R:T106 R:R:Y110 6.24 0 No Yes 4 8 2 1
R:R:Y110 R:R:Y179 2.98 7 Yes Yes 8 5 1 2
R:R:G234 R:R:Y110 4.35 7 Yes Yes 3 8 1 1
R:R:L235 R:R:Y110 4.69 7 Yes Yes 3 8 2 1
R:R:L235 R:R:Y179 7.03 7 Yes Yes 3 5 2 2
R:R:L229 R:R:P230 4.93 0 No Yes 5 9 2 1
R:R:N261 R:R:P230 9.77 7 No Yes 9 9 1 1
R:R:G228 R:R:P230 2.03 0 No Yes 7 9 2 1
R:R:A233 R:R:G234 1.95 0 No Yes 6 3 2 1
R:R:A237 R:R:G234 1.95 0 No Yes 5 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
22.22Single9USTA1D6H9UST-MRGPRE-A1D6H-chim(NtGi1-Gs-CtGq)/β1/γ2

PDB Summary
PDB 8YFS
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRE
Species Equus Quagga
Ligand A1D6H
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.8
Date 2025-03-05
D.O.I. To be published
Net Summary
Imin 2.77
Number of Linked Nodes 809
Number of Links 1033
Number of Hubs 195
Number of Links mediated by Hubs 675
Number of Communities 23
Number of Nodes involved in Communities 248
Number of Links involved in Communities 385
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 1997973
Length Of Smallest Path 3
Average Path Length 24.7902
Length of Longest Path 50
Minimum Path Strength 1.255
Average Path Strength 6.47716
Maximum Path Strength 24.715
Minimum Path Correlation 0.7
Average Path Correlation 0.982451
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 45.7746
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.9067
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8YFS_Chain_A
EKAEKIEKQ LQKDKQVYR TRLLLLGAS GKSTIVKQM RIHTSGIFE 
TKFQVDKVN FHMFDVGQR DERRKWIQC FNDVTAIIF VVSSYNRLQ 
EALNFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG KSKIEDYFP 
EFARYTTPE DATPEPGED PRVTRAKYF IREFISTAS GDGRHCYPH 
FTCVDTENR RFNDCDIIM LRYLTLSAD AVRSMRLDN YKADDDKVD 
ISAIKLQNE NV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8YFS_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8YFS_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtA0A9L0JPP9
Sequence
>8YFS_Chain_R
LFLAVLSLC GLVGNGTVI WLLGRIKRN PFSVYILNL AGADFAFLF 
CKSVRFLLL NRSVAVLNV LIRGVTFSS YLGGLSLLM AVSVERCLS 
VLFPIWYRC RRAQLSAIA CALIWGLSL CGILVFLCV HFVDFCDVV 
NLVYGMFFL TFLVLCASS LLIVQCFRI VLLTVLAFL VLGLPLGAG 
LLDRLSPSL PFDILLPIL HLLSALNSG VNPLIYFFM GRTTVLVLM 
LNALWAC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YFSAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ22.82025-03-05To be published
8YFS (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-2.82025-03-05To be published
9USTAOrphanOrphanMRGPREEquus quaggaA1D6H-chim(NtGi1-Gs-CtGq)/β1/γ23.022025-07-02To be published
9UST (No Gprot) AOrphanOrphanMRGPREEquus quaggaA1D6H-3.022025-07-02To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YFS.zip



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