psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S83	3.14	Yes	No	1	0	6
2	L:L:?1	R:R:F87	5.95	Yes	Yes	0	0	6
3	L:L:?1	R:R:H107	9.87	Yes	Yes	1	0	5
4	L:L:?1	R:R:F111	12.75	Yes	Yes	1	0	6
5	L:L:?1	R:R:R170	5.09	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y183	28.64	Yes	Yes	1	0	4
7	L:L:?1	R:R:Y184	11.46	Yes	Yes	1	0	4
8	L:L:?1	R:R:Y262	9	Yes	Yes	1	0	7
9	L:L:?1	R:R:L286	11.59	Yes	Yes	1	0	5
10	L:L:?1	R:R:F294	5.1	Yes	No	1	0	6
11	R:R:E15	R:R:L10	3.98	No	No	0	7	7
12	R:R:C11	R:R:L187	3.17	No	Yes	4	7	4
13	R:R:C11	R:R:C199	7.28	No	No	4	7	2
14	R:R:H273	R:R:P12	3.05	Yes	No	0	1	6
15	R:R:P12	R:R:R279	5.76	No	Yes	0	6	1
16	R:R:I13	R:R:M17	4.37	No	No	0	7	7
17	R:R:E269	R:R:I13	4.1	No	No	0	5	7
18	R:R:H273	R:R:I13	5.3	Yes	No	0	1	7
19	R:R:Q16	R:R:R279	3.5	No	Yes	0	7	1
20	R:R:M17	R:R:W283	9.31	No	No	0	7	4
21	R:R:R19	R:R:S18	9.22	No	No	0	5	7
22	R:R:L20	R:R:S22	4.5	No	No	0	5	4
23	R:R:L20	R:R:W283	4.56	No	No	0	5	4
24	R:R:H23	R:R:S22	13.95	No	No	0	5	4
25	R:R:H23	R:R:H95	25.08	No	No	0	5	4
26	R:R:S24	R:R:Y30	7.63	No	No	0	4	2
27	R:R:T26	R:R:Y30	7.49	No	No	0	3	2
28	R:R:H33	R:R:L91	11.57	No	No	0	3	5
29	R:R:H33	R:R:H95	9.55	No	No	0	3	4
30	R:R:L91	R:R:V36	2.98	No	No	0	5	4
31	R:R:F87	R:R:H39	6.79	Yes	No	0	6	8
32	R:R:H39	R:R:T88	5.48	No	No	0	8	7
33	R:R:L41	R:R:L45	9.69	No	No	0	5	6
34	R:R:A42	R:R:F295	6.93	No	No	0	7	5
35	R:R:L47	R:R:S43	3	No	Yes	0	6	7
36	R:R:L84	R:R:S43	9.01	No	Yes	0	8	7
37	R:R:L44	R:R:V48	2.98	No	No	0	6	5
38	R:R:L47	R:R:S81	3	No	Yes	0	6	6
39	R:R:E49	R:R:V298	4.28	No	No	0	7	8
40	R:R:D77	R:R:N50	10.77	Yes	Yes	2	9	9
41	R:R:L78	R:R:N50	5.49	No	Yes	0	8	9
42	R:R:N50	R:R:P301	3.26	Yes	No	2	9	9
43	R:R:A74	R:R:I53	3.25	No	Yes	0	9	9
44	R:R:I53	R:R:P301	3.39	Yes	No	0	9	9
45	R:R:I53	R:R:V305	3.07	Yes	No	0	9	7
46	R:R:L315	R:R:V56	4.47	No	Yes	0	5	7
47	R:R:T67	R:R:V57	3.17	No	No	0	7	7
48	R:R:L71	R:R:V57	7.45	Yes	No	0	6	7
49	R:R:K314	R:R:M61	12.96	No	No	0	4	6
50	R:R:T64	R:R:T67	9.42	No	No	0	7	7
51	R:R:V65	R:R:W69	3.68	No	Yes	2	5	7
52	R:R:R143	R:R:V65	7.85	Yes	No	2	7	5
53	R:R:A148	R:R:V65	5.09	No	No	2	7	5
54	R:R:H149	R:R:T68	15.06	No	No	0	4	7
55	R:R:A124	R:R:W69	5.19	No	Yes	0	7	7
56	R:R:I125	R:R:W69	5.87	No	Yes	2	8	7
57	R:R:A148	R:R:W69	3.89	No	Yes	2	7	7
58	R:R:V151	R:R:W69	3.68	No	Yes	2	5	7
59	R:R:C152	R:R:W69	7.84	No	Yes	0	7	7
60	R:R:M311	R:R:V70	6.09	Yes	No	0	8	8
61	R:R:C152	R:R:H72	14.74	No	No	0	7	9
62	R:R:H72	R:R:W156	6.35	No	No	0	9	9
63	R:R:L73	R:R:S76	3	No	Yes	2	9	8
64	R:R:D77	R:R:L73	8.14	Yes	No	2	9	9
65	R:R:L73	R:R:Y304	3.52	No	Yes	2	9	9
66	R:R:L75	R:R:L79	5.54	No	No	0	6	6
67	R:R:D77	R:R:S76	4.42	Yes	Yes	2	9	8
68	R:R:S118	R:R:S76	3.26	No	Yes	0	9	8
69	R:R:L121	R:R:S76	3	No	Yes	0	7	8
70	R:R:D77	R:R:S297	8.83	Yes	No	0	9	9
71	R:R:D77	R:R:P301	4.83	Yes	No	2	9	9
72	R:R:L79	R:R:N114	5.49	No	No	0	6	8
73	R:R:A80	R:R:N114	6.25	No	No	0	7	8
74	R:R:L84	R:R:S81	3	No	Yes	0	8	6
75	R:R:S297	R:R:S81	3.26	No	Yes	0	9	6
76	R:R:H107	R:R:S83	9.76	Yes	No	1	5	6
77	R:R:F294	R:R:L84	10.96	No	No	0	6	8
78	R:R:F103	R:R:F86	4.29	Yes	No	1	6	7
79	R:R:F86	R:R:H107	7.92	No	Yes	1	7	5
80	R:R:F87	R:R:F90	3.22	Yes	No	0	6	5
81	R:R:F87	R:R:L91	12.18	Yes	No	0	6	5
82	R:R:F90	R:R:W97	55.12	No	Yes	0	5	9
83	R:R:G94	R:R:H95	3.18	No	No	0	3	4
84	R:R:F103	R:R:W97	26.06	Yes	Yes	1	6	9
85	R:R:H107	R:R:W97	3.17	Yes	Yes	1	5	9
86	R:R:C182	R:R:W97	11.75	No	Yes	1	9	9
87	R:R:F103	R:R:L99	4.87	Yes	No	0	6	7
88	R:R:F103	R:R:H107	13.58	Yes	Yes	1	6	5
89	R:R:C104	R:R:R170	4.18	No	Yes	1	9	5
90	R:R:C104	R:R:C182	5.46	No	No	1	9	9
91	R:R:F167	R:R:K105	6.2	No	No	0	4	7
92	R:R:R170	R:R:S108	15.81	Yes	No	0	5	5
93	R:R:F167	R:R:S109	6.61	No	No	0	4	5
94	R:R:I110	R:R:N114	4.25	No	No	0	5	8
95	R:R:F111	R:R:F112	4.29	Yes	Yes	1	6	5
96	R:R:F111	R:R:Y262	6.19	Yes	Yes	1	6	7
97	R:R:F111	R:R:F294	5.36	Yes	No	1	6	6
98	R:R:F112	R:R:F116	3.22	Yes	Yes	0	5	7
99	R:R:F112	R:R:Y166	30.95	Yes	Yes	1	5	4
100	R:R:F112	R:R:Y184	6.19	Yes	Yes	1	5	4
101	R:R:L113	R:R:W156	5.69	No	No	0	5	9
102	R:R:L113	R:R:V160	5.96	No	No	0	5	4
103	R:R:A214	R:R:M115	4.83	No	No	0	6	8
104	R:R:M115	R:R:W259	9.31	No	Yes	0	8	8
105	R:R:F116	R:R:F120	8.57	Yes	Yes	0	7	6
106	R:R:F116	R:R:N162	8.46	Yes	No	0	7	5
107	R:R:F116	R:R:L213	6.09	Yes	No	0	7	4
108	R:R:A117	R:R:W156	7.78	No	No	0	7	9
109	R:R:F120	R:R:L155	9.74	Yes	No	2	6	7
110	R:R:F120	W:W:?1	3.33	Yes	Yes	2	6	0
111	R:R:L122	R:R:Y304	4.69	No	Yes	0	9	9
112	R:R:P218	R:R:S123	3.56	No	No	0	9	7
113	R:R:I221	R:R:S123	4.64	Yes	No	0	7	7
114	R:R:S123	W:W:?1	5.13	No	Yes	0	7	0
115	R:R:A124	W:W:?1	5.38	No	Yes	0	7	0
116	R:R:I125	R:R:R129	6.26	No	No	2	8	9
117	R:R:I125	R:R:Y304	6.04	No	Yes	2	8	9
118	R:R:I222	R:R:S126	7.74	No	No	0	8	9
119	R:R:S126	R:R:S225	3.26	No	Yes	3	9	8
120	R:R:L127	W:W:?1	8.5	No	Yes	0	6	0
121	R:R:D128	R:R:Q132	11.75	No	No	2	8	7
122	R:R:D128	R:R:R143	8.34	No	Yes	2	8	7
123	R:R:D128	W:W:?1	5.56	No	Yes	2	8	0
124	R:R:R129	R:R:Y304	4.12	No	Yes	2	9	9
125	R:R:C130	R:R:S225	3.44	No	Yes	0	8	8
126	R:R:Q132	R:R:R143	17.52	No	Yes	2	7	7
127	R:R:V133	R:R:V229	12.83	No	No	0	8	8
128	R:R:R135	R:R:V134	5.23	No	No	0	6	8
129	R:R:R232	R:R:V134	10.46	No	No	0	5	8
130	R:R:N141	R:R:V137	4.43	No	No	0	5	6
131	R:R:H142	R:R:W138	17.98	No	No	2	4	4
132	R:R:W138	W:W:?1	6.22	No	Yes	2	4	0
133	R:R:H142	R:R:N141	6.38	No	No	0	4	5
134	R:R:H142	W:W:?1	14.04	No	Yes	2	4	0
135	R:R:R143	W:W:?1	4.15	Yes	Yes	2	7	0
136	R:R:A147	W:W:?1	9.68	No	Yes	0	3	0
137	R:R:K150	W:W:?1	8.66	No	Yes	0	2	0
138	R:R:L155	R:R:V151	2.98	No	No	2	7	5
139	R:R:V151	W:W:?1	10.17	No	Yes	2	5	0
140	R:R:L158	R:R:V154	2.98	No	No	0	5	3
141	R:R:V154	W:W:?1	8.14	No	Yes	0	3	0
142	R:R:L155	W:W:?1	5.67	No	Yes	2	7	0
143	R:R:T163	R:R:V160	3.17	No	No	0	7	4
144	R:R:P165	R:R:V164	3.53	No	No	0	7	4
145	R:R:Y166	R:R:Y184	6.95	Yes	Yes	1	4	4
146	R:R:L206	R:R:Y166	3.52	No	Yes	0	5	4
147	R:R:K210	R:R:Y166	5.97	Yes	Yes	1	5	4
148	R:R:F169	R:R:V168	5.24	No	No	0	5	4
149	R:R:L189	R:R:V168	10.43	No	No	0	5	4
150	R:R:F169	R:R:V186	7.87	No	No	0	5	5
151	R:R:C182	R:R:R170	6.96	No	Yes	1	9	5
152	R:R:R170	R:R:Y184	6.17	Yes	Yes	1	5	4
153	R:R:D171	R:R:N185	12.12	No	No	0	5	4
154	R:R:Y183	R:R:Y184	11.91	Yes	Yes	1	4	4
155	R:R:E269	R:R:Y183	6.73	No	Yes	0	5	4
156	R:R:L286	R:R:Y183	4.69	Yes	Yes	1	5	4
157	R:R:R202	R:R:V186	9.15	No	No	0	3	5
158	R:R:L187	R:R:T198	2.95	Yes	Yes	0	4	3
159	R:R:C199	R:R:L187	4.76	No	Yes	4	2	4
160	R:R:L188	R:R:L189	4.15	No	No	0	7	5
161	R:R:N190	R:R:P191	3.26	No	No	0	7	6
162	R:R:G192	R:R:P193	4.06	No	No	0	5	5
163	R:R:G192	R:R:T198	3.64	No	Yes	0	5	3
164	R:R:D194	R:R:P193	3.22	No	No	0	1	5
165	R:R:A197	R:R:D196	4.63	No	No	0	1	2
166	R:R:S201	R:R:T198	3.2	No	Yes	0	1	3
167	R:R:R202	R:R:T198	6.47	No	Yes	0	3	3
168	R:R:C199	R:R:H273	2.95	No	Yes	0	2	1
169	R:R:N200	R:R:V204	4.43	No	No	0	1	2
170	R:R:H273	R:R:N200	16.58	Yes	No	0	1	1
171	R:R:L212	R:R:V208	2.98	No	No	0	6	4
172	R:R:K210	R:R:Y262	4.78	Yes	Yes	1	5	7
173	R:R:H263	R:R:K210	3.93	Yes	Yes	1	8	5
174	R:R:K210	R:R:S266	7.65	Yes	No	0	5	5
175	R:R:F211	R:R:L212	3.65	Yes	No	1	6	6
176	R:R:F211	R:R:F215	7.5	Yes	Yes	1	6	9
177	R:R:F211	R:R:L216	8.53	Yes	No	1	6	5
178	R:R:F211	R:R:H263	5.66	Yes	Yes	1	6	8
179	R:R:L212	R:R:L216	4.15	No	No	1	6	5
180	R:R:F215	R:R:L219	3.65	Yes	No	1	9	5
181	R:R:F215	R:R:F255	4.29	Yes	No	1	9	9
182	R:R:F215	R:R:G260	4.52	Yes	No	0	9	5
183	R:R:F215	R:R:H263	6.79	Yes	Yes	1	9	8
184	R:R:P218	R:R:V217	3.53	No	No	0	9	5
185	R:R:I221	R:R:V217	3.07	Yes	No	0	7	5
186	R:R:F255	R:R:L219	4.87	No	No	1	9	5
187	R:R:H226	R:R:I222	6.63	No	No	0	9	8
188	R:R:H226	R:R:V248	19.37	No	No	0	9	7
189	R:R:L233	R:R:V229	2.98	No	No	0	8	8
190	R:R:F244	R:R:V229	5.24	No	No	0	7	8
191	R:R:F244	R:R:S230	5.28	No	No	0	7	5
192	R:R:H235	R:R:L231	3.86	No	No	0	4	4
193	R:R:L233	R:R:R238	3.64	No	No	0	8	3
194	R:R:L233	R:R:R240	3.64	No	No	0	8	5
195	R:R:Q234	R:R:R240	5.84	No	No	0	5	5
196	R:R:R238	R:R:R239	12.79	No	No	0	3	4
197	R:R:P241	R:R:R239	8.65	No	No	0	6	4
198	R:R:R243	R:R:R246	4.26	No	No	0	7	5
199	R:R:F244	R:R:V248	7.87	No	No	0	7	7
200	R:R:L247	R:R:T307	5.9	No	No	0	7	7
201	R:R:A250	R:R:L303	3.15	No	No	0	6	8
202	R:R:L303	R:R:V251	5.96	No	No	0	8	8
203	R:R:V251	R:R:Y304	5.05	No	Yes	0	8	9
204	R:R:F255	R:R:W259	12.03	No	Yes	1	9	8
205	R:R:C258	R:R:W259	3.92	No	Yes	1	8	8
206	R:R:C258	R:R:N296	9.45	No	No	1	8	9
207	R:R:N296	R:R:W259	14.69	No	Yes	1	9	8
208	R:R:G260	R:R:P261	4.06	No	No	0	5	9
209	R:R:P261	R:R:V289	3.53	No	No	0	9	7
210	R:R:H263	R:R:Y262	6.53	Yes	Yes	1	8	7
211	R:R:T290	R:R:Y262	4.99	No	Yes	0	6	7
212	R:R:L268	R:R:V264	2.98	No	No	0	5	6
213	R:R:F265	R:R:G285	4.52	Yes	No	0	5	5
214	R:R:F265	R:R:V289	10.49	Yes	No	0	5	7
215	R:R:E269	R:R:V282	11.41	No	No	0	5	4
216	R:R:P276	R:R:R279	5.76	No	Yes	0	1	1
217	R:R:R279	R:R:W283	3	Yes	No	0	1	4
218	R:R:L286	R:R:V282	2.98	Yes	No	0	5	4
219	R:R:L286	R:R:P287	3.28	Yes	No	0	5	4
220	R:R:F295	R:R:L292	4.87	No	No	0	5	7
221	R:R:N296	R:R:N300	14.98	No	No	0	9	9
222	R:R:L306	R:R:V302	4.47	No	No	0	7	6
223	R:R:L306	R:R:V305	2.98	No	No	0	7	7
224	R:R:M311	R:R:V305	3.04	Yes	No	0	8	7
225	R:R:L306	R:R:L312	4.15	No	No	0	7	7
226	R:R:C308	R:R:D310	4.67	Yes	No	5	8	5
227	R:R:C308	R:R:M311	4.86	Yes	Yes	5	8	8
228	R:R:D310	R:R:M311	4.16	No	Yes	5	5	8
229	R:R:L319	R:R:R316	10.93	No	No	0	7	5
230	R:R:R317	R:R:T321	3.88	No	No	0	4	3
231	R:R:S318	R:R:T321	3.2	No	No	0	4	3
232	R:R:R320	R:R:T321	3.88	No	No	0	5	3
233	R:R:M311	R:R:M61	2.89	Yes	No	0	8	6
234	R:R:I53	R:R:L315	2.85	Yes	No	0	9	5
235	R:R:L54	R:R:L71	2.77	No	Yes	0	7	6
236	R:R:L54	R:R:L75	2.77	No	No	0	7	6
237	R:R:A159	R:R:F120	2.77	No	Yes	0	8	6
238	R:R:A139	R:R:R143	2.77	No	Yes	0	5	7
239	R:R:H149	R:R:V145	2.77	No	No	0	4	1
240	R:R:L14	R:R:N185	2.75	No	No	0	7	4
241	R:R:L188	R:R:N185	2.75	No	No	0	7	4
242	R:R:H72	R:R:T68	2.74	No	No	0	9	7
243	R:R:A92	R:R:Y89	2.67	No	No	0	4	4
244	R:R:L71	R:R:Q63	2.66	Yes	No	0	6	5
245	R:R:E98	R:R:L99	2.65	No	No	0	3	7
246	R:R:R60	R:R:V56	2.62	No	Yes	0	5	7
247	R:R:R232	R:R:V133	2.62	No	No	0	5	8
248	R:R:A293	R:R:W259	2.59	No	Yes	0	8	8
249	R:R:L247	R:R:R246	2.43	No	No	0	7	5
250	R:R:E15	R:R:R19	2.33	No	No	0	7	5
251	R:R:G242	R:R:P241	2.03	No	No	0	5	6
252	R:R:C308	R:R:P309	1.88	Yes	No	0	8	5
253	R:R:G40	R:R:S43	1.86	No	Yes	0	4	7
254	R:R:G46	R:R:S81	1.86	No	Yes	0	8	6
255	R:R:G119	R:R:S118	1.86	No	No	0	7	9
256	R:R:G46	R:R:V298	1.84	No	No	0	8	8
257	R:R:G242	R:R:V245	1.84	No	No	0	5	5
258	R:R:A228	R:R:C130	1.81	No	No	0	3	8
259	R:R:A207	R:R:A270	1.79	No	No	0	5	5
260	R:R:A254	R:R:A299	1.79	No	No	0	7	6
261	R:R:P85	R:R:S43	1.78	No	Yes	0	9	7
262	R:R:G46	R:R:L45	1.71	No	No	0	8	6
263	R:R:G58	R:R:L71	1.71	No	Yes	0	4	6
264	R:R:A80	R:R:S297	1.71	No	No	0	7	9
265	R:R:G100	R:R:L99	1.71	No	No	0	8	7
266	R:R:A207	R:R:S266	1.71	No	No	0	5	5
267	R:R:G51	R:R:N50	1.7	No	Yes	0	5	9
268	R:R:C104	R:R:T101	1.69	No	No	0	9	4
269	R:R:C308	R:R:T307	1.69	Yes	No	0	8	7
270	R:R:A146	R:R:T144	1.68	No	No	0	4	6
271	R:R:A147	R:R:T144	1.68	No	No	0	3	6
272	R:R:L206	R:R:P165	1.64	No	No	0	5	7
273	R:R:L187	R:R:P191	1.64	Yes	No	0	4	6
274	R:R:S108	R:R:S109	1.63	No	No	0	5	5
275	R:R:S224	R:R:S225	1.63	No	Yes	3	4	8
276	R:R:N275	R:R:P276	1.63	No	No	0	2	1
277	R:R:S318	R:R:V56	1.62	No	Yes	0	4	7
278	R:R:S96	R:R:V93	1.62	No	No	0	4	4
279	R:R:S318	R:R:V322	1.62	No	No	0	4	4
280	R:R:V48	R:R:V52	1.6	No	No	0	5	6
281	R:R:V52	R:R:V56	1.6	No	Yes	0	6	7
282	R:R:V66	R:R:V70	1.6	No	No	0	7	8
283	R:R:V248	R:R:V252	1.6	No	No	0	7	8
284	R:R:A82	R:R:L47	1.58	No	No	0	5	6
285	R:R:A207	R:R:L267	1.58	No	No	0	5	6
286	R:R:A254	R:R:L303	1.58	No	No	0	7	8
287	R:R:A272	R:R:L278	1.58	No	No	0	3	1
288	R:R:T101	R:R:T102	1.57	No	No	0	4	3
289	R:R:A274	R:R:N200	1.56	No	No	0	1	1
290	R:R:A274	R:R:N275	1.56	No	No	0	1	2
291	R:R:I221	R:R:S126	1.55	Yes	No	3	7	9
292	R:R:I221	R:R:S224	1.55	Yes	No	3	7	4
293	R:R:I221	R:R:S225	1.55	Yes	Yes	3	7	8
294	R:R:A197	R:R:D194	1.54	No	No	0	1	1
295	R:R:A270	R:R:Q203	1.52	No	No	0	5	3
296	R:R:L206	R:R:S209	1.5	No	No	0	5	4
297	R:R:L37	R:R:T88	1.47	No	No	0	5	7
298	R:R:P136	R:R:R135	1.44	No	No	0	8	6
299	R:R:P280	R:R:R279	1.44	No	Yes	0	2	1
300	R:R:K105	R:R:L106	1.41	No	No	0	7	4
301	R:R:C59	R:R:F55	1.4	No	No	0	5	4
302	R:R:A272	R:R:R279	1.38	No	Yes	0	3	1
303	R:R:L231	R:R:Q234	1.33	No	No	0	4	5
304	R:R:R284	R:R:S22	1.32	No	No	0	1	4
305	R:R:F288	R:R:V289	1.31	No	No	0	5	7
306	R:R:F265	R:R:L268	1.22	Yes	No	0	5	5
307	R:R:F265	R:R:L281	1.22	Yes	No	0	5	2
308	R:R:F288	R:R:L292	1.22	No	No	0	5	7
309	R:R:L187	R:R:R195	1.21	Yes	No	0	4	2
310	R:R:N275	R:R:R271	1.21	No	No	0	2	3
311	R:R:Q21	R:R:R19	1.17	No	No	0	5	5
312	R:R:L131	R:R:W138	1.14	No	No	0	6	4
313	R:R:R232	R:R:R236	1.07	No	No	0	5	5
314	R:R:R316	R:R:R320	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.259	10	1	0
2	R:R:S43	3.9125	4	0	7
3	R:R:N50	5.305	4	2	9
4	R:R:I53	3.14	4	0	9
5	R:R:V56	2.5775	4	0	7
6	R:R:W69	5.025	6	2	7
7	R:R:L71	3.6475	4	0	6
8	R:R:S76	3.42	4	2	8
9	R:R:D77	7.398	5	2	9
10	R:R:S81	2.78	4	0	6
11	R:R:F87	7.035	4	0	6
12	R:R:W97	24.025	4	1	9
13	R:R:F103	12.2	4	1	6
14	R:R:H107	8.86	5	1	5
15	R:R:F111	7.1475	4	1	6
16	R:R:F112	11.1625	4	1	5
17	R:R:F116	6.585	4	0	7
18	R:R:F120	6.1025	4	2	6
19	R:R:R143	8.126	5	2	7
20	R:R:Y166	11.8475	4	1	4
21	R:R:R170	7.642	5	1	5
22	R:R:Y183	12.9925	4	1	4
23	R:R:Y184	8.536	5	1	4
24	R:R:L187	2.746	5	4	4
25	R:R:T198	4.065	4	0	3
26	R:R:K210	5.5825	4	1	5
27	R:R:F211	6.335	4	1	6
28	R:R:F215	5.35	5	1	9
29	R:R:I221	2.472	5	3	7
30	R:R:S225	2.47	4	3	8
31	R:R:W259	8.508	5	1	8
32	R:R:Y262	6.298	5	1	7
33	R:R:H263	5.7275	4	1	8
34	R:R:F265	4.3625	4	0	5
35	R:R:H273	6.97	4	0	1
36	R:R:R279	3.47333	6	0	1
37	R:R:L286	5.635	4	1	5
38	R:R:Y304	4.684	5	2	9
39	R:R:C308	3.275	4	5	8
40	R:R:M311	4.208	5	5	8
41	W:W:?1	7.27923	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y183	32.3818	28.64	Yes	Yes	1	0	4
2	R:R:E269	R:R:Y183	62.8257	6.73	No	Yes	0	5	4
3	R:R:E269	R:R:I13	62.0236	4.1	No	No	0	5	7
4	R:R:H273	R:R:I13	48.6973	5.3	Yes	No	0	1	7
5	R:R:C199	R:R:H273	33.0444	2.95	No	Yes	0	2	1
6	R:R:C199	R:R:L187	30.2795	4.76	No	Yes	4	2	4
7	R:R:H273	R:R:P12	11.229	3.05	Yes	No	0	1	6
8	R:R:I13	R:R:M17	14.3526	4.37	No	No	0	7	7
9	R:R:M17	R:R:W283	12.9378	9.31	No	No	0	7	4
10	L:L:?1	R:R:F87	23.7134	5.95	Yes	Yes	0	0	6
11	R:R:F87	R:R:L91	14.4921	12.18	Yes	No	0	6	5
12	R:R:H33	R:R:L91	10.7757	11.57	No	No	0	3	5
13	L:L:?1	R:R:F294	46.7892	5.1	Yes	No	1	0	6
14	R:R:F294	R:R:L84	67.125	10.96	No	No	0	6	8
15	R:R:L84	R:R:S81	62.0236	3	No	Yes	0	8	6
16	L:L:?1	R:R:Y262	27.7388	9	Yes	Yes	1	0	7
17	R:R:H263	R:R:Y262	46.2412	6.53	Yes	Yes	1	8	7
18	R:R:F215	R:R:H263	50.4857	6.79	Yes	Yes	1	9	8
19	R:R:F215	R:R:G260	28.2569	4.52	Yes	No	0	9	5
20	R:R:G260	R:R:P261	25.9353	4.06	No	No	0	5	9
21	R:R:P261	R:R:V289	23.6038	3.53	No	No	0	9	7
22	R:R:S297	R:R:S81	57.3706	3.26	No	Yes	0	9	6
23	R:R:D77	R:R:S297	55.9458	8.83	Yes	No	0	9	9
24	R:R:D77	R:R:P301	52.593	4.83	Yes	No	2	9	9
25	R:R:I53	R:R:P301	51.5568	3.39	Yes	No	0	9	9
26	R:R:I53	R:R:L315	22.747	2.85	Yes	No	0	9	5
27	R:R:L315	R:R:V56	21.2076	4.47	No	Yes	0	5	7
28	R:R:I53	R:R:V305	27.8135	3.07	Yes	No	0	9	7
29	R:R:A80	R:R:S297	20.9784	1.71	No	No	0	7	9
30	R:R:A80	R:R:N114	19.2846	6.25	No	No	0	7	8
31	R:R:L79	R:R:N114	15.8671	5.49	No	No	0	6	8
32	R:R:L75	R:R:L79	14.1434	5.54	No	No	0	6	6
33	R:R:L54	R:R:L75	12.4097	2.77	No	No	0	7	6
34	R:R:L54	R:R:L71	10.6661	2.77	No	Yes	0	7	6
35	R:R:M311	R:R:V305	21.0581	3.04	Yes	No	0	8	7
36	L:L:?1	R:R:F111	12.9029	12.75	Yes	Yes	1	0	6
37	R:R:F111	R:R:F112	35.6349	4.29	Yes	Yes	1	6	5
38	R:R:F112	R:R:F116	100	3.22	Yes	Yes	0	5	7
39	R:R:F116	R:R:F120	98.2813	8.57	Yes	Yes	0	7	6
40	R:R:F120	W:W:?1	82.6732	3.33	Yes	Yes	2	6	0
41	R:R:F120	R:R:L155	15.8173	9.74	Yes	No	2	6	7
42	R:R:L155	R:R:V151	15.1846	2.98	No	No	2	7	5
43	R:R:V151	R:R:W69	45.7978	3.68	No	Yes	2	5	7
44	R:R:V151	W:W:?1	32.4266	10.17	No	Yes	2	5	0
45	R:R:A124	W:W:?1	32.3669	5.38	No	Yes	0	7	0
46	R:R:A124	R:R:W69	31.5797	5.19	No	Yes	0	7	7
47	L:L:?1	R:R:Y184	15.2892	11.46	Yes	Yes	1	0	4
48	R:R:F112	R:R:Y184	45.9672	6.19	Yes	Yes	1	5	4
49	R:R:C152	R:R:W69	37.4085	7.84	No	Yes	0	7	7
50	R:R:C152	R:R:H72	33.7568	14.74	No	No	0	7	9
51	R:R:H72	R:R:T68	11.3386	2.74	No	No	0	9	7
52	R:R:I125	R:R:W69	44.2485	5.87	No	Yes	2	8	7
53	R:R:D77	R:R:L73	39.9741	8.14	Yes	No	2	9	9
54	R:R:L73	R:R:Y304	42.2408	3.52	No	Yes	2	9	9
55	R:R:I125	R:R:Y304	39.1969	6.04	No	Yes	2	8	9
56	R:R:H72	R:R:W156	18.8512	6.35	No	No	0	9	9
57	L:L:?1	R:R:H107	13.416	9.87	Yes	Yes	1	0	5
58	R:R:L113	R:R:W156	11.3386	5.69	No	No	0	5	9
59	R:R:F215	R:R:F255	19.1252	4.29	Yes	No	1	9	9
60	R:R:F255	R:R:W259	16.8037	12.03	No	Yes	1	9	8
61	R:R:S123	W:W:?1	61.6002	5.13	No	Yes	0	7	0
62	R:R:I221	R:R:S123	56.3144	4.64	Yes	No	0	7	7
63	R:R:I221	R:R:S126	45.469	1.55	Yes	No	3	7	9
64	R:R:I222	R:R:S126	44.1339	7.74	No	No	0	8	9
65	R:R:H226	R:R:I222	42.3106	6.63	No	No	0	9	8
66	R:R:H226	R:R:V248	40.4673	19.37	No	No	0	9	7
67	R:R:F244	R:R:V248	36.9402	7.87	No	No	0	7	7
68	R:R:F244	R:R:V229	33.1938	5.24	No	No	0	7	8
69	R:R:V133	R:R:V229	11.9364	12.83	No	No	0	8	8
70	R:R:R232	R:R:V133	10.0981	2.62	No	No	0	5	8
71	R:R:L187	R:R:T198	24.6201	2.95	Yes	Yes	0	4	3
72	R:R:R202	R:R:T198	14.1583	6.47	No	Yes	0	3	3
73	R:R:R202	R:R:V186	12.6239	9.15	No	No	0	3	5
74	R:R:F169	R:R:V186	11.0796	7.87	No	No	0	5	5
75	R:R:K210	R:R:S266	11.3037	7.65	Yes	No	0	5	5
76	R:R:L233	R:R:V229	19.9621	2.98	No	No	0	8	8
77	R:R:L233	R:R:R238	10.1081	3.64	No	No	0	8	3
78	R:R:C308	R:R:M311	10.5913	4.86	Yes	Yes	5	8	8
79	R:R:F265	R:R:V289	11.7969	10.49	Yes	No	0	5	7
80	R:R:S318	R:R:V56	12.5442	1.62	No	Yes	0	4	7
81	R:R:F111	R:R:F294	21.2574	5.36	Yes	No	1	6	6
82	R:R:F111	R:R:Y262	28.6255	6.19	Yes	Yes	1	6	7
83	R:R:F112	R:R:Y166	22.4232	30.95	Yes	Yes	1	5	4
84	R:R:Y183	R:R:Y184	32.5711	11.91	Yes	Yes	1	4	4
85	R:R:K210	R:R:Y166	20.5002	5.97	Yes	Yes	1	5	4
86	R:R:H263	R:R:K210	15.6379	3.93	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S83	3.14	1	Yes	No	0	6	0	1
L:L:?1	R:R:F87	5.95	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:H107	9.87	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F111	12.75	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R170	5.09	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y183	28.64	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y184	11.46	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y262	9	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L286	11.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F294	5.1	1	Yes	No	0	6	0	1
R:R:F87	R:R:H39	6.79	0	Yes	No	6	8	1	2
R:R:H107	R:R:S83	9.76	1	Yes	No	5	6	1	1
R:R:F294	R:R:L84	10.96	1	No	No	6	8	1	2
R:R:F103	R:R:F86	4.29	1	Yes	No	6	7	2	2
R:R:F86	R:R:H107	7.92	1	No	Yes	7	5	2	1
R:R:F87	R:R:F90	3.22	0	Yes	No	6	5	1	2
R:R:F87	R:R:L91	12.18	0	Yes	No	6	5	1	2
R:R:F90	R:R:W97	55.12	0	No	Yes	5	9	2	2
R:R:F103	R:R:W97	26.06	1	Yes	Yes	6	9	2	2
R:R:H107	R:R:W97	3.17	1	Yes	Yes	5	9	1	2
R:R:C182	R:R:W97	11.75	1	No	Yes	9	9	2	2
R:R:F103	R:R:H107	13.58	1	Yes	Yes	6	5	2	1
R:R:C104	R:R:R170	4.18	1	No	Yes	9	5	2	1
R:R:C104	R:R:C182	5.46	1	No	No	9	9	2	2
R:R:R170	R:R:S108	15.81	1	Yes	No	5	5	1	2
R:R:F111	R:R:F112	4.29	1	Yes	Yes	6	5	1	2
R:R:F111	R:R:Y262	6.19	1	Yes	Yes	6	7	1	1
R:R:F111	R:R:F294	5.36	1	Yes	No	6	6	1	1
R:R:F112	R:R:Y166	30.95	1	Yes	Yes	5	4	2	2
R:R:F112	R:R:Y184	6.19	1	Yes	Yes	5	4	2	1
R:R:Y166	R:R:Y184	6.95	1	Yes	Yes	4	4	2	1
R:R:K210	R:R:Y166	5.97	1	Yes	Yes	5	4	2	2
R:R:C182	R:R:R170	6.96	1	No	Yes	9	5	2	1
R:R:R170	R:R:Y184	6.17	1	Yes	Yes	5	4	1	1
R:R:Y183	R:R:Y184	11.91	1	Yes	Yes	4	4	1	1
R:R:E269	R:R:Y183	6.73	0	No	Yes	5	4	2	1
R:R:L286	R:R:Y183	4.69	1	Yes	Yes	5	4	1	1
R:R:K210	R:R:Y262	4.78	1	Yes	Yes	5	7	2	1
R:R:H263	R:R:K210	3.93	1	Yes	Yes	8	5	2	2
R:R:H263	R:R:Y262	6.53	1	Yes	Yes	8	7	2	1
R:R:T290	R:R:Y262	4.99	0	No	Yes	6	7	2	1
R:R:E269	R:R:V282	11.41	0	No	No	5	4	2	2
R:R:L286	R:R:V282	2.98	1	Yes	No	5	4	1	2
R:R:L286	R:R:P287	3.28	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V65	R:R:W69	3.68	2	No	Yes	5	7	2	2
R:R:R143	R:R:V65	7.85	2	Yes	No	7	5	1	2
R:R:A124	R:R:W69	5.19	0	No	Yes	7	7	1	2
R:R:V151	R:R:W69	3.68	2	No	Yes	5	7	1	2
R:R:F116	R:R:F120	8.57	0	Yes	Yes	7	6	2	1
R:R:F120	R:R:L155	9.74	2	Yes	No	6	7	1	1
R:R:F120	W:W:?1	3.33	2	Yes	Yes	6	0	1	0
R:R:P218	R:R:S123	3.56	0	No	No	9	7	2	1
R:R:I221	R:R:S123	4.64	3	Yes	No	7	7	2	1
R:R:S123	W:W:?1	5.13	0	No	Yes	7	0	1	0
R:R:A124	W:W:?1	5.38	0	No	Yes	7	0	1	0
R:R:L127	W:W:?1	8.5	0	No	Yes	6	0	1	0
R:R:D128	R:R:Q132	11.75	2	No	No	8	7	1	2
R:R:D128	R:R:R143	8.34	2	No	Yes	8	7	1	1
R:R:D128	W:W:?1	5.56	2	No	Yes	8	0	1	0
R:R:Q132	R:R:R143	17.52	2	No	Yes	7	7	2	1
R:R:H142	R:R:W138	17.98	2	No	No	4	4	1	1
R:R:W138	W:W:?1	6.22	2	No	Yes	4	0	1	0
R:R:H142	R:R:N141	6.38	2	No	No	4	5	1	2
R:R:H142	W:W:?1	14.04	2	No	Yes	4	0	1	0
R:R:R143	W:W:?1	4.15	2	Yes	Yes	7	0	1	0
R:R:A147	W:W:?1	9.68	0	No	Yes	3	0	1	0
R:R:K150	W:W:?1	8.66	0	No	Yes	2	0	1	0
R:R:L155	R:R:V151	2.98	2	No	No	7	5	1	1
R:R:V151	W:W:?1	10.17	2	No	Yes	5	0	1	0
R:R:L158	R:R:V154	2.98	0	No	No	5	3	2	1
R:R:V154	W:W:?1	8.14	0	No	Yes	3	0	1	0
R:R:L155	W:W:?1	5.67	2	No	Yes	7	0	1	0
R:R:A159	R:R:F120	2.77	0	No	Yes	8	6	2	1
R:R:A139	R:R:R143	2.77	0	No	Yes	5	7	2	1
R:R:A147	R:R:T144	1.68	0	No	No	3	6	1	2
R:R:L131	R:R:W138	1.14	0	No	No	6	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XXV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	279
Number of Links	314
Number of Hubs	41
Number of Links mediated by Hubs	160
Number of Communities	5
Number of Nodes involved in Communities	58
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	55063
Length Of Smallest Path	3
Average Path Length	13.5884
Length of Longest Path	34
Minimum Path Strength	1.22
Average Path Strength	6.30319
Maximum Path Strength	40.59
Minimum Path Correlation	0.7
Average Path Correlation	0.93554
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	53.5247
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6747
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of signaling • immune response • immune system process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • multicellular organismal process • negative regulation of male germ cell proliferation • sexual reproduction • regulation of reproductive process • reproductive process • regulation of male germ cell proliferation • negative regulation of biological process • gamete generation • germ cell proliferation • regulation of germ cell proliferation • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell population proliferation • cell population proliferation • multicellular organismal reproductive process • male germ cell proliferation • negative regulation of reproductive process • regulation of cell population proliferation • negative regulation of multicellular organismal process • negative regulation of germ cell proliferation • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to prostaglandin E • cellular response to forskolin • response to forskolin • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cellular response to prostaglandin E stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IMN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IMN
Name	Indomethacin
Synonyms	1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
Identifier
Formula	C19 H16 Cl N O4
Molecular Weight	357.788
SMILES
PubChem	3715
Formal Charge	0
Total Atoms	41
Total Chiral Atoms	0
Total Bonds	43
Total Aromatic Bonds	16


Code	A1D
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5Y4
Sequence	>8XXV_nogp_Chain_R L C P I L E Q M S R L Q S H S N T S I R Y H A A V L L H G L A S L L G L V E N G V I L F V V G C R M R Q T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G H S W E L G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R P V W A Q N H R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D M C Y Y N V L L L N P G P D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R G R R R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A H A N P G L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D M L R K L R R S L R T V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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