psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E15	R:R:L10	3.98	No	No	0	7	7
2	R:R:C11	R:R:P12	3.77	Yes	No	1	7	6
3	R:R:C11	R:R:L187	3.17	Yes	No	0	7	4
4	R:R:C11	R:R:C199	7.28	Yes	No	0	7	2
5	R:R:C11	R:R:H273	2.95	Yes	Yes	1	7	1
6	R:R:P12	R:R:R195	2.88	No	No	0	6	2
7	R:R:H273	R:R:P12	3.05	Yes	No	1	1	6
8	R:R:I13	R:R:M17	4.37	No	Yes	1	7	7
9	R:R:I13	R:R:Y183	13.3	No	Yes	1	7	4
10	R:R:H273	R:R:I13	5.3	Yes	No	1	1	7
11	R:R:L14	R:R:S18	3	No	No	0	7	7
12	R:R:D171	R:R:L14	4.07	Yes	No	0	5	7
13	R:R:L14	R:R:Y183	8.21	No	Yes	0	7	4
14	R:R:E15	R:R:R195	4.65	No	No	0	7	2
15	R:R:Q16	R:R:R279	4.67	No	Yes	0	7	1
16	R:R:M17	R:R:Y183	8.38	Yes	Yes	1	7	4
17	R:R:E269	R:R:M17	2.71	No	Yes	0	5	7
18	R:R:M17	R:R:W283	5.82	Yes	Yes	0	7	4
19	R:R:R19	R:R:S18	6.59	No	No	0	5	7
20	R:R:L20	R:R:S22	3	No	No	0	5	4
21	R:R:L20	R:R:W283	11.39	No	Yes	0	5	4
22	R:R:H23	R:R:R179	5.64	No	No	0	5	1
23	R:R:S24	R:R:Y30	6.36	No	No	0	4	2
24	R:R:T26	R:R:Y30	7.49	No	No	0	3	2
25	R:R:H33	R:R:Y30	4.36	No	No	0	3	2
26	R:R:G178	R:R:V36	3.68	No	No	0	5	4
27	R:R:H39	R:R:S291	4.18	No	No	0	8	5
28	R:R:F294	R:R:H39	12.44	Yes	No	0	6	8
29	R:R:L41	R:R:L44	2.77	No	No	0	5	6
30	R:R:A42	R:R:F295	4.16	No	No	0	7	5
31	R:R:P85	R:R:S43	7.13	No	No	0	9	7
32	R:R:F86	R:R:L44	2.44	No	No	0	7	6
33	R:R:L47	R:R:L78	2.77	Yes	Yes	2	6	8
34	R:R:L47	R:R:S81	10.51	Yes	No	0	6	6
35	R:R:F86	R:R:L47	2.44	No	Yes	0	7	6
36	R:R:E49	R:R:V298	5.7	No	No	0	7	8
37	R:R:E49	R:R:P301	3.14	No	Yes	0	7	9
38	R:R:E49	R:R:V302	4.28	No	No	0	7	6
39	R:R:D77	R:R:N50	13.46	No	No	2	9	9
40	R:R:L78	R:R:N50	8.24	Yes	No	2	8	9
41	R:R:N50	R:R:P301	3.26	No	Yes	2	9	9
42	R:R:I53	R:R:V52	3.07	Yes	No	0	9	6
43	R:R:A74	R:R:I53	3.25	No	Yes	0	9	9
44	R:R:I53	R:R:P301	3.39	Yes	Yes	0	9	9
45	R:R:I53	R:R:V305	4.61	Yes	No	0	9	7
46	R:R:L54	R:R:L71	2.77	No	No	0	7	6
47	R:R:A74	R:R:L54	4.73	No	No	0	9	7
48	R:R:C59	R:R:F55	2.79	No	No	0	5	4
49	R:R:R60	R:R:V56	3.92	No	Yes	3	5	7
50	R:R:K314	R:R:V56	4.55	No	Yes	3	4	7
51	R:R:M61	R:R:V57	9.13	Yes	No	3	6	7
52	R:R:T67	R:R:V57	3.17	No	No	3	7	7
53	R:R:L71	R:R:V57	7.45	No	No	0	6	7
54	R:R:K314	R:R:R60	12.38	No	No	3	4	5
55	R:R:M61	R:R:T67	4.52	Yes	No	3	6	7
56	R:R:M311	R:R:M61	4.33	Yes	Yes	0	8	6
57	R:R:K314	R:R:M61	8.64	No	Yes	3	4	6
58	R:R:L71	R:R:Q63	3.99	No	No	0	6	5
59	R:R:T64	R:R:T67	10.99	No	No	0	7	7
60	R:R:V65	R:R:W69	3.68	No	Yes	0	5	7
61	R:R:R143	R:R:V65	10.46	No	No	0	7	5
62	R:R:H72	R:R:T68	2.74	Yes	No	0	9	7
63	R:R:H149	R:R:T68	10.95	No	No	0	4	7
64	R:R:A124	R:R:W69	5.19	No	Yes	0	7	7
65	R:R:I125	R:R:W69	8.22	No	Yes	0	8	7
66	R:R:A148	R:R:W69	3.89	No	Yes	0	7	7
67	R:R:V151	R:R:W69	3.68	No	Yes	0	5	7
68	R:R:C152	R:R:W69	5.22	No	Yes	0	7	7
69	R:R:M311	R:R:V70	6.09	Yes	No	0	8	8
70	R:R:H72	R:R:L121	2.57	Yes	No	0	9	7
71	R:R:C152	R:R:H72	14.74	No	Yes	0	7	9
72	R:R:H72	R:R:W156	3.17	Yes	Yes	0	9	9
73	R:R:L73	R:R:S118	3	Yes	No	0	9	9
74	R:R:L121	R:R:L73	2.77	No	Yes	0	7	9
75	R:R:L73	R:R:N300	2.75	Yes	No	0	9	9
76	R:R:L73	R:R:Y304	3.52	Yes	Yes	0	9	9
77	R:R:L75	R:R:L79	4.15	No	No	0	6	6
78	R:R:N114	R:R:S76	4.47	Yes	Yes	0	8	8
79	R:R:A117	R:R:S76	3.42	No	Yes	6	7	8
80	R:R:S118	R:R:S76	3.26	No	Yes	0	9	8
81	R:R:S76	R:R:W156	4.94	Yes	Yes	6	8	9
82	R:R:D77	R:R:S297	11.78	No	No	0	9	9
83	R:R:D77	R:R:P301	6.44	No	Yes	2	9	9
84	R:R:A80	R:R:N114	6.25	No	Yes	0	7	8
85	R:R:L84	R:R:S83	3	Yes	No	0	8	6
86	R:R:I110	R:R:S83	9.29	No	No	0	5	6
87	R:R:L84	R:R:P85	3.28	Yes	No	0	8	9
88	R:R:H107	R:R:L84	3.86	No	Yes	0	5	8
89	R:R:F111	R:R:L84	2.44	Yes	Yes	1	6	8
90	R:R:F294	R:R:L84	8.53	Yes	Yes	1	6	8
91	R:R:F103	R:R:T88	5.19	Yes	No	0	6	7
92	R:R:D177	R:R:Y89	17.24	No	No	0	3	4
93	R:R:F90	R:R:L91	6.09	No	No	0	5	5
94	R:R:F103	R:R:L91	8.53	Yes	No	0	6	5
95	R:R:E98	R:R:F103	9.33	No	Yes	0	3	6
96	R:R:K105	R:R:T101	3	Yes	No	0	7	4
97	R:R:D171	R:R:T101	4.34	Yes	No	0	5	4
98	R:R:K105	R:R:T102	4.5	Yes	No	0	7	3
99	R:R:C104	R:R:R170	5.57	No	Yes	1	9	5
100	R:R:C104	R:R:T172	10.14	No	No	0	9	6
101	R:R:C104	R:R:C182	7.28	No	No	1	9	9
102	R:R:F167	R:R:K105	2.48	No	Yes	0	4	7
103	R:R:K105	R:R:R170	4.95	Yes	Yes	0	7	5
104	R:R:I110	R:R:L106	7.14	No	No	0	5	4
105	R:R:C182	R:R:H107	10.32	No	No	0	9	5
106	R:R:F112	R:R:S108	6.61	Yes	No	0	5	5
107	R:R:R170	R:R:S108	15.81	Yes	No	0	5	5
108	R:R:F167	R:R:S109	7.93	No	No	0	4	5
109	R:R:I110	R:R:N114	5.66	No	Yes	0	5	8
110	R:R:F111	R:R:F112	4.29	Yes	Yes	1	6	5
111	R:R:F111	R:R:Y262	10.32	Yes	Yes	1	6	7
112	R:R:F111	R:R:T290	2.59	Yes	No	1	6	6
113	R:R:F111	R:R:F294	7.5	Yes	Yes	1	6	6
114	R:R:F112	R:R:M115	2.49	Yes	Yes	1	5	8
115	R:R:F112	R:R:T163	2.59	Yes	No	0	5	7
116	R:R:F112	R:R:Y166	13.41	Yes	Yes	1	5	4
117	R:R:F112	R:R:K210	4.96	Yes	Yes	1	5	5
118	R:R:F112	R:R:Y262	5.16	Yes	Yes	1	5	7
119	R:R:L113	R:R:W156	6.83	No	Yes	0	5	9
120	R:R:L113	R:R:V160	4.47	No	No	0	5	4
121	R:R:F116	R:R:M115	4.98	Yes	Yes	1	7	8
122	R:R:A214	R:R:M115	4.83	No	Yes	1	6	8
123	R:R:M115	R:R:W259	12.8	Yes	Yes	0	8	8
124	R:R:H263	R:R:M115	5.25	Yes	Yes	1	8	8
125	R:R:F116	R:R:F120	3.22	Yes	No	0	7	6
126	R:R:F116	R:R:T163	2.59	Yes	No	0	7	7
127	R:R:F116	R:R:K210	2.48	Yes	Yes	1	7	5
128	R:R:F116	R:R:L213	6.09	Yes	No	0	7	4
129	R:R:A214	R:R:F116	2.77	No	Yes	1	6	7
130	R:R:A117	R:R:W156	7.78	No	Yes	6	7	9
131	R:R:G119	R:R:P218	4.06	No	No	0	7	9
132	R:R:F120	R:R:L155	9.74	No	No	0	6	7
133	R:R:A159	R:R:F120	2.77	No	No	0	8	6
134	R:R:F255	R:R:L122	2.44	No	No	0	9	9
135	R:R:L122	R:R:N300	2.75	No	No	0	9	9
136	R:R:L122	R:R:Y304	5.86	No	Yes	0	9	9
137	R:R:P218	R:R:S123	3.56	No	No	0	9	7
138	R:R:I221	R:R:S123	4.64	Yes	No	0	7	7
139	R:R:I125	R:R:R129	6.26	No	No	5	8	9
140	R:R:I125	R:R:Y304	3.63	No	Yes	5	8	9
141	R:R:I222	R:R:S126	9.29	No	No	0	8	9
142	R:R:S126	R:R:S225	3.26	No	No	0	9	8
143	R:R:I221	R:R:L127	4.28	Yes	No	0	7	6
144	R:R:L127	W:W:?1	6.2	No	Yes	0	6	0
145	R:R:D128	R:R:Q132	10.44	No	No	4	8	7
146	R:R:D128	R:R:R143	7.15	No	No	4	8	7
147	R:R:D128	W:W:?1	6.08	No	Yes	4	8	0
148	R:R:R129	R:R:Y304	3.09	No	Yes	5	9	9
149	R:R:C130	R:R:S225	3.44	No	No	0	8	8
150	R:R:Q132	R:R:R143	11.68	No	No	4	7	7
151	R:R:V133	R:R:V229	12.83	No	No	0	8	8
152	R:R:R232	R:R:V133	2.62	No	No	0	5	8
153	R:R:R135	R:R:V134	5.23	No	No	0	6	8
154	R:R:R232	R:R:V134	9.15	No	No	0	5	8
155	R:R:N141	R:R:V137	4.43	No	No	0	5	6
156	R:R:H142	R:R:W138	21.16	No	No	4	4	4
157	R:R:W138	W:W:?1	8.5	No	Yes	4	4	0
158	R:R:H142	R:R:N141	6.38	No	No	0	4	5
159	R:R:H142	W:W:?1	27.83	No	Yes	4	4	0
160	R:R:H149	R:R:V145	2.77	No	No	0	4	1
161	R:R:A147	W:W:?1	7.06	No	Yes	0	3	0
162	R:R:K150	W:W:?1	7.37	No	Yes	0	2	0
163	R:R:L155	R:R:V151	2.98	No	No	0	7	5
164	R:R:L158	R:R:V154	2.98	No	No	0	5	3
165	R:R:T163	R:R:V160	3.17	No	No	0	7	4
166	R:R:L213	R:R:N162	9.61	No	No	0	4	5
167	R:R:P165	R:R:V164	3.53	No	No	0	7	4
168	R:R:Y166	R:R:Y184	9.93	Yes	Yes	1	4	4
169	R:R:L206	R:R:Y166	14.07	Yes	Yes	1	5	4
170	R:R:S209	R:R:Y166	6.36	No	Yes	0	4	4
171	R:R:K210	R:R:Y166	7.17	Yes	Yes	1	5	4
172	R:R:F169	R:R:V168	11.8	No	No	0	5	4
173	R:R:L189	R:R:V168	4.47	No	No	0	5	4
174	R:R:F169	R:R:V186	22.28	No	No	0	5	5
175	R:R:F169	R:R:L206	2.44	No	Yes	0	5	5
176	R:R:C182	R:R:R170	5.57	No	Yes	1	9	5
177	R:R:R170	R:R:Y184	15.43	Yes	Yes	1	5	4
178	R:R:D171	R:R:N185	6.73	Yes	No	0	5	4
179	R:R:D171	R:R:L188	4.07	Yes	No	0	5	7
180	R:R:M181	R:R:T172	3.01	No	No	0	4	6
181	R:R:I173	R:R:S174	3.1	No	No	0	3	1
182	R:R:D177	R:R:G178	6.71	No	No	0	3	5
183	R:R:Y183	R:R:Y184	2.98	Yes	Yes	1	4	4
184	R:R:N185	R:R:Y183	3.49	No	Yes	0	4	4
185	R:R:Q203	R:R:Y184	16.91	No	Yes	0	3	4
186	R:R:L206	R:R:Y184	11.72	Yes	Yes	1	5	4
187	R:R:L187	R:R:N185	10.98	No	No	0	4	4
188	R:R:R202	R:R:V186	11.77	No	No	0	3	5
189	R:R:N190	R:R:R202	4.82	No	No	0	7	3
190	R:R:G192	R:R:P193	4.06	No	No	0	5	5
191	R:R:A197	R:R:D194	4.63	No	No	0	1	1
192	R:R:D194	R:R:T198	5.78	No	No	0	1	3
193	R:R:D196	R:R:H273	8.82	No	Yes	0	2	1
194	R:R:N200	R:R:V204	4.43	No	No	0	1	2
195	R:R:H273	R:R:N200	16.58	Yes	No	0	1	1
196	R:R:L212	R:R:V208	2.98	No	No	0	6	4
197	R:R:K210	R:R:Y262	7.17	Yes	Yes	1	5	7
198	R:R:H263	R:R:K210	9.17	Yes	Yes	1	8	5
199	R:R:K210	R:R:S266	7.65	Yes	No	0	5	5
200	R:R:F211	R:R:L212	3.65	Yes	No	1	6	6
201	R:R:F211	R:R:F215	9.65	Yes	Yes	1	6	9
202	R:R:F211	R:R:L216	8.53	Yes	No	1	6	5
203	R:R:F211	R:R:H263	9.05	Yes	Yes	1	6	8
204	R:R:L212	R:R:L216	4.15	No	No	1	6	5
205	R:R:A214	R:R:H263	2.93	No	Yes	1	6	8
206	R:R:F215	R:R:L219	3.65	Yes	No	0	9	5
207	R:R:F215	R:R:G260	6.02	Yes	No	0	9	5
208	R:R:F215	R:R:H263	3.39	Yes	Yes	1	9	8
209	R:R:P218	R:R:V217	3.53	No	No	0	9	5
210	R:R:I221	R:R:V217	3.07	Yes	No	0	7	5
211	R:R:F255	R:R:L219	3.65	No	No	0	9	5
212	R:R:I221	R:R:S224	3.1	Yes	No	0	7	4
213	R:R:H226	R:R:I222	5.3	No	No	0	9	8
214	R:R:H226	R:R:V248	16.61	No	No	0	9	7
215	R:R:L233	R:R:V229	2.98	No	No	0	8	8
216	R:R:F244	R:R:V229	3.93	Yes	No	0	7	8
217	R:R:F244	R:R:S230	5.28	Yes	No	0	7	5
218	R:R:H235	R:R:L231	3.86	No	No	0	4	4
219	R:R:L233	R:R:R238	4.86	No	No	0	8	3
220	R:R:L233	R:R:R240	8.5	No	Yes	0	8	5
221	R:R:Q234	R:R:R240	8.18	No	Yes	0	5	5
222	R:R:R238	R:R:R239	6.4	No	No	0	3	4
223	R:R:F244	R:R:R240	4.28	Yes	Yes	7	7	5
224	R:R:R243	R:R:R246	5.33	No	No	0	7	5
225	R:R:F244	R:R:V248	6.55	Yes	No	0	7	7
226	R:R:L247	R:R:T307	4.42	No	No	0	7	7
227	R:R:A250	R:R:L303	3.15	No	No	0	6	8
228	R:R:V251	R:R:Y304	8.83	No	Yes	0	8	9
229	R:R:F255	R:R:W259	13.03	No	Yes	0	9	8
230	R:R:C258	R:R:N296	7.87	No	No	0	8	9
231	R:R:A293	R:R:W259	3.89	No	Yes	0	8	8
232	R:R:N296	R:R:W259	14.69	No	Yes	0	9	8
233	R:R:G260	R:R:P261	4.06	No	No	0	5	9
234	R:R:P261	R:R:V289	3.53	No	No	0	9	7
235	R:R:H263	R:R:Y262	5.44	Yes	Yes	1	8	7
236	R:R:L268	R:R:V264	2.98	No	No	0	5	6
237	R:R:F265	R:R:G285	4.52	No	No	0	5	5
238	R:R:F265	R:R:V289	5.24	No	No	0	5	7
239	R:R:E269	R:R:V282	8.56	No	No	0	5	4
240	R:R:P276	R:R:R279	5.76	No	Yes	0	1	1
241	R:R:R279	R:R:W283	3	Yes	Yes	0	1	4
242	R:R:L286	R:R:P287	3.28	No	No	0	5	4
243	R:R:F294	R:R:T290	5.19	Yes	No	1	6	6
244	R:R:F295	R:R:S291	3.96	No	No	0	5	5
245	R:R:N296	R:R:N300	14.98	No	No	0	9	9
246	R:R:L306	R:R:V305	2.98	No	No	0	7	7
247	R:R:L306	R:R:L312	2.77	No	No	0	7	7
248	R:R:C308	R:R:M311	4.86	No	Yes	0	8	8
249	R:R:D310	R:R:P309	3.22	No	No	0	5	5
250	R:R:D310	R:R:M311	6.93	No	Yes	0	5	8
251	R:R:R313	R:R:R317	26.66	No	No	0	5	4
252	R:R:L319	R:R:R316	3.64	No	No	0	7	5
253	R:R:R316	R:R:R320	3.2	No	No	0	5	5
254	R:R:S318	R:R:T321	3.2	No	No	0	4	3
255	R:R:L319	R:R:L323	2.77	No	No	0	7	5
256	R:R:L323	R:R:R320	7.29	No	No	0	5	5
257	R:R:E324	R:R:S325	4.31	No	No	0	4	5
258	R:R:L131	W:W:?1	2.07	No	Yes	0	6	0
259	R:R:G192	R:R:P191	2.03	No	No	0	5	6
260	R:R:G242	R:R:P241	2.03	No	No	0	5	6
261	R:R:G285	R:R:P287	2.03	No	No	0	5	4
262	R:R:G40	R:R:S43	1.86	No	No	0	4	7
263	R:R:G100	R:R:S174	1.86	Yes	No	0	8	1
264	R:R:G46	R:R:V298	1.84	No	No	0	8	8
265	R:R:G242	R:R:V245	1.84	No	No	0	5	5
266	R:R:G100	R:R:T172	1.82	Yes	No	0	8	6
267	R:R:G192	R:R:T198	1.82	No	No	0	5	3
268	R:R:A228	R:R:C130	1.81	No	No	0	3	8
269	R:R:A254	R:R:A299	1.79	No	No	0	7	6
270	R:R:G46	R:R:L45	1.71	No	No	0	8	6
271	R:R:G51	R:R:L78	1.71	No	Yes	0	5	8
272	R:R:C308	R:R:V66	1.71	No	No	0	8	7
273	R:R:A80	R:R:S297	1.71	No	No	0	7	9
274	R:R:G100	R:R:L99	1.71	Yes	No	0	8	7
275	R:R:A207	R:R:S266	1.71	No	No	0	5	5
276	R:R:A270	R:R:V204	1.7	No	No	0	5	2
277	R:R:C308	R:R:T307	1.69	No	No	0	8	7
278	R:R:A146	R:R:T144	1.68	No	No	0	4	6
279	R:R:A147	R:R:T144	1.68	No	No	0	3	6
280	R:R:L206	R:R:P165	1.64	Yes	No	0	5	7
281	R:R:N190	R:R:P191	1.63	No	No	0	7	6
282	R:R:S224	R:R:S225	1.63	No	No	0	4	8
283	R:R:N275	R:R:P276	1.63	No	No	0	2	1
284	R:R:S318	R:R:V56	1.62	No	Yes	0	4	7
285	R:R:S318	R:R:V322	1.62	No	No	0	4	4
286	R:R:V248	R:R:V252	1.6	No	No	0	7	8
287	R:R:A82	R:R:L47	1.58	No	Yes	2	5	6
288	R:R:A82	R:R:L78	1.58	No	Yes	2	5	8
289	R:R:A207	R:R:L267	1.58	No	No	0	5	6
290	R:R:A254	R:R:L303	1.58	No	No	0	7	8
291	R:R:A272	R:R:L278	1.58	No	No	0	3	1
292	R:R:A274	R:R:N275	1.56	No	No	0	1	2
293	R:R:A139	R:R:Q132	1.52	No	No	0	5	7
294	R:R:F103	R:R:G100	1.51	Yes	Yes	0	6	8
295	R:R:F288	R:R:G285	1.51	No	No	0	5	5
296	R:R:L91	R:R:S96	1.5	No	No	0	5	4
297	R:R:G242	R:R:R246	1.5	No	No	0	5	5
298	R:R:L315	R:R:V52	1.49	No	No	0	5	6
299	R:R:L315	R:R:V56	1.49	No	Yes	0	5	7
300	R:R:L268	R:R:V282	1.49	No	No	0	5	4
301	R:R:L327	R:R:V326	1.49	No	No	0	4	5
302	R:R:D32	R:R:V36	1.46	No	No	0	4	4
303	R:R:P136	R:R:R135	1.44	No	No	0	8	6
304	R:R:P241	R:R:R240	1.44	No	Yes	7	6	5
305	R:R:F244	R:R:P241	1.44	Yes	No	7	7	6
306	R:R:P280	R:R:R279	1.44	No	Yes	0	2	1
307	R:R:H23	R:R:S22	1.39	No	No	0	5	4
308	R:R:A272	R:R:R279	1.38	No	Yes	0	3	1
309	R:R:L278	R:R:L281	1.38	No	No	0	1	2
310	R:R:L79	R:R:N114	1.37	No	Yes	0	6	8
311	R:R:L158	R:R:N162	1.37	No	No	0	5	5
312	R:R:L231	R:R:Q234	1.33	No	No	0	4	5
313	R:R:R284	R:R:S22	1.32	No	No	0	1	4
314	R:R:R202	R:R:S201	1.32	No	No	0	3	1
315	R:R:R317	R:R:T321	1.29	No	No	0	4	3
316	R:R:D32	R:R:H33	1.26	No	No	0	4	3
317	R:R:S96	R:R:W97	1.24	No	No	0	4	9
318	R:R:L303	R:R:Y304	1.17	No	Yes	0	8	9
319	R:R:E324	R:R:R320	1.16	No	No	0	4	5
320	R:R:Q21	R:R:W283	1.1	No	Yes	0	5	4
321	R:R:R232	R:R:R236	1.07	No	No	0	5	5
322	R:R:R236	R:R:R238	1.07	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C11	4.2925	4	1	7
2	R:R:M17	5.32	4	1	7
3	R:R:L47	4.325	4	2	6
4	R:R:I53	3.58	4	0	9
5	R:R:V56	2.895	4	3	7
6	R:R:M61	6.655	4	3	6
7	R:R:W69	4.98	6	0	7
8	R:R:H72	5.805	4	0	9
9	R:R:L73	3.01	4	0	9
10	R:R:S76	4.0225	4	6	8
11	R:R:L78	3.575	4	2	8
12	R:R:L84	4.222	5	1	8
13	R:R:G100	1.725	4	0	8
14	R:R:F103	6.14	4	0	6
15	R:R:K105	3.7325	4	0	7
16	R:R:F111	5.428	5	1	6
17	R:R:F112	5.64429	7	1	5
18	R:R:N114	4.4375	4	0	8
19	R:R:M115	6.07	5	1	8
20	R:R:F116	3.68833	6	1	7
21	R:R:W156	5.68	4	6	9
22	R:R:Y166	10.188	5	1	4
23	R:R:R170	9.466	5	1	5
24	R:R:D171	4.8025	4	0	5
25	R:R:Y183	7.272	5	1	4
26	R:R:Y184	11.394	5	1	4
27	R:R:L206	7.4675	4	1	5
28	R:R:K210	6.43333	6	1	5
29	R:R:F211	7.72	4	1	6
30	R:R:F215	5.6775	4	1	9
31	R:R:I221	3.7725	4	0	7
32	R:R:R240	5.6	4	7	5
33	R:R:F244	4.296	5	7	7
34	R:R:W259	11.1025	4	0	8
35	R:R:Y262	7.0225	4	1	7
36	R:R:H263	5.87167	6	1	8
37	R:R:H273	7.34	5	1	1
38	R:R:R279	3.25	5	0	1
39	R:R:W283	5.3275	4	0	4
40	R:R:F294	8.415	4	1	6
41	R:R:P301	4.0575	4	2	9
42	R:R:Y304	4.35	6	5	9
43	R:R:M311	5.5525	4	0	8
44	W:W:?1	9.30143	7	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H273	R:R:I13	18.4747	5.3	Yes	No	1	1	7
2	R:R:I13	R:R:Y183	18.8743	13.3	No	Yes	1	7	4
3	R:R:M17	R:R:W283	26.6834	5.82	Yes	Yes	0	7	4
4	R:R:R279	R:R:W283	15.4457	3	Yes	Yes	0	1	4
5	R:R:Y183	R:R:Y184	65.6751	2.98	Yes	Yes	1	4	4
6	R:R:Y166	R:R:Y184	55.2415	9.93	Yes	Yes	1	4	4
7	R:R:F112	R:R:Y166	33.5159	13.41	Yes	Yes	1	5	4
8	R:R:F111	R:R:F112	39.9586	4.29	Yes	Yes	1	6	5
9	R:R:F111	R:R:F294	10.108	7.5	Yes	Yes	1	6	6
10	R:R:F294	R:R:H39	10.1574	12.44	Yes	No	0	6	8
11	R:R:F111	R:R:L84	38.3898	2.44	Yes	Yes	1	6	8
12	R:R:L84	R:R:S83	55.3352	3	Yes	No	0	8	6
13	R:R:I110	R:R:S83	55.0145	9.29	No	No	0	5	6
14	R:R:I110	R:R:N114	54.4818	5.66	No	Yes	0	5	8
15	R:R:A80	R:R:N114	78.1659	6.25	No	Yes	0	7	8
16	R:R:A80	R:R:S297	77.0658	1.71	No	No	0	7	9
17	R:R:D77	R:R:S297	75.9558	11.78	No	No	0	9	9
18	R:R:D77	R:R:N50	12.5154	13.46	No	No	2	9	9
19	R:R:L78	R:R:N50	12.9397	8.24	Yes	No	2	8	9
20	R:R:R170	R:R:Y184	29.7963	15.43	Yes	Yes	1	5	4
21	R:R:C182	R:R:R170	19.4514	5.57	No	Yes	1	9	5
22	R:R:C182	R:R:H107	23.3092	10.32	No	No	0	9	5
23	R:R:H107	R:R:L84	25.3219	3.86	No	Yes	0	5	8
24	R:R:D77	R:R:P301	62.3156	6.44	No	Yes	2	9	9
25	R:R:I53	R:R:P301	56.8546	3.39	Yes	Yes	0	9	9
26	R:R:I53	R:R:V52	28.1338	3.07	Yes	No	0	9	6
27	R:R:A74	R:R:I53	23.7729	3.25	No	Yes	0	9	9
28	R:R:A74	R:R:L54	22.3176	4.73	No	No	0	9	7
29	R:R:L54	R:R:L71	20.8968	2.77	No	No	0	7	6
30	R:R:L315	R:R:V52	26.7278	1.49	No	No	0	5	6
31	R:R:L315	R:R:V56	25.4206	1.49	No	Yes	0	5	7
32	R:R:K314	R:R:V56	15.3668	4.55	No	Yes	3	4	7
33	R:R:K314	R:R:M61	13.9904	8.64	No	Yes	3	4	6
34	R:R:L71	R:R:V57	18.0948	7.45	No	No	0	6	7
35	R:R:M61	R:R:V57	13.6698	9.13	Yes	No	3	6	7
36	R:R:M311	R:R:M61	24.2761	4.33	Yes	Yes	0	8	6
37	R:R:K210	R:R:Y166	39.1643	7.17	Yes	Yes	1	5	4
38	R:R:F116	R:R:K210	52.0152	2.48	Yes	Yes	1	7	5
39	R:R:F116	R:R:F120	76.2666	3.22	Yes	No	0	7	6
40	R:R:F120	R:R:L155	73.6027	9.74	No	No	0	6	7
41	R:R:L155	R:R:V151	72.9219	2.98	No	No	0	7	5
42	R:R:V151	R:R:W69	72.2806	3.68	No	Yes	0	5	7
43	R:R:V65	R:R:W69	100	3.68	No	Yes	0	5	7
44	R:R:R143	R:R:V65	98.5299	10.46	No	No	0	7	5
45	R:R:F112	R:R:T163	20.1914	2.59	Yes	No	0	5	7
46	R:R:T163	R:R:V160	11.8642	3.17	No	No	0	7	4
47	R:R:L113	R:R:V160	11.4844	4.47	No	No	0	5	4
48	R:R:L113	R:R:W156	11.1736	6.83	No	Yes	0	5	9
49	R:R:H72	R:R:W156	29.076	3.17	Yes	Yes	0	9	9
50	R:R:F112	R:R:M115	25.5636	2.49	Yes	Yes	1	5	8
51	R:R:M115	R:R:W259	11.7754	12.8	Yes	Yes	0	8	8
52	R:R:F255	R:R:L122	14.2223	2.44	No	No	0	9	9
53	R:R:L122	R:R:Y304	13.8671	5.86	No	Yes	0	9	9
54	R:R:I125	R:R:Y304	10.848	3.63	No	Yes	5	8	9
55	R:R:I125	R:R:W69	10.8973	8.22	No	Yes	0	8	7
56	R:R:C152	R:R:W69	25.0851	5.22	No	Yes	0	7	7
57	R:R:C152	R:R:H72	25.1887	14.74	No	Yes	0	7	9
58	R:R:S76	R:R:W156	28.5383	4.94	Yes	Yes	6	8	9
59	R:R:C104	R:R:R170	31.2811	5.57	No	Yes	1	9	5
60	R:R:C104	R:R:T172	34.241	10.14	No	No	0	9	6
61	R:R:G100	R:R:T172	29.081	1.82	Yes	No	0	8	6
62	R:R:F103	R:R:G100	18.6424	1.51	Yes	Yes	0	6	8
63	R:R:F103	R:R:L91	10.7099	8.53	Yes	No	0	6	5
64	R:R:K105	R:R:R170	14.3555	4.95	Yes	Yes	0	7	5
65	R:R:R170	R:R:S108	31.3157	15.81	Yes	No	0	5	5
66	R:R:H263	R:R:K210	12.3872	9.17	Yes	Yes	1	8	5
67	R:R:D128	R:R:R143	93.7102	7.15	No	No	4	8	7
68	R:R:D128	W:W:?1	92.7532	6.08	No	Yes	4	8	0
69	R:R:L127	W:W:?1	77.3716	6.2	No	Yes	0	6	0
70	R:R:I221	R:R:L127	75.7733	4.28	Yes	No	0	7	6
71	R:R:I221	R:R:S224	64.4369	3.1	Yes	No	0	7	4
72	R:R:S224	R:R:S225	62.7596	1.63	No	No	0	4	8
73	R:R:S126	R:R:S225	57.6686	3.26	No	No	0	9	8
74	R:R:I222	R:R:S126	55.9519	9.29	No	No	0	8	9
75	R:R:H226	R:R:I222	54.2252	5.3	No	No	0	9	8
76	R:R:H226	R:R:V248	52.4789	16.61	No	No	0	9	7
77	R:R:F244	R:R:V248	49.0997	6.55	Yes	No	0	7	7
78	R:R:F244	R:R:V229	21.1287	3.93	Yes	No	0	7	8
79	R:R:V133	R:R:V229	11.7557	12.83	No	No	0	8	8
80	R:R:F169	R:R:L206	17.8827	2.44	No	Yes	0	5	5
81	R:R:F169	R:R:V186	13.9066	22.28	No	No	0	5	5
82	R:R:R202	R:R:V186	12.5598	11.77	No	No	0	3	5
83	R:R:F211	R:R:H263	10.3744	9.05	Yes	Yes	1	6	8
84	R:R:F215	R:R:H263	14.6811	3.39	Yes	Yes	1	9	8
85	R:R:F215	R:R:G260	15.8206	6.02	Yes	No	0	9	5
86	R:R:F244	R:R:R240	15.3076	4.28	Yes	Yes	7	7	5
87	R:R:L233	R:R:R238	11.662	4.86	No	No	0	8	3
88	R:R:C308	R:R:M311	12.1109	4.86	No	Yes	0	8	8
89	R:R:G260	R:R:P261	13.877	4.06	No	No	0	5	9
90	R:R:P261	R:R:V289	11.9234	3.53	No	No	0	9	7
91	R:R:M17	R:R:Y183	33.2347	8.38	Yes	Yes	1	7	4
92	R:R:F112	R:R:S108	32.8499	6.61	Yes	No	0	5	5
93	R:R:N114	R:R:S76	35.0205	4.47	Yes	Yes	0	8	8
94	R:R:F116	R:R:M115	16.3485	4.98	Yes	Yes	1	7	8
95	R:R:F116	R:R:T163	17.1772	2.59	Yes	No	0	7	7
96	R:R:F112	R:R:K210	16.8763	4.96	Yes	Yes	1	5	5
97	R:R:F111	R:R:Y262	11.8494	10.32	Yes	Yes	1	6	7
98	R:R:L206	R:R:Y166	16.2547	14.07	Yes	Yes	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I221	R:R:L127	4.28	0	Yes	No	7	6	2	1
R:R:L127	W:W:?1	6.2	0	No	Yes	6	0	1	0
R:R:D128	R:R:Q132	10.44	4	No	No	8	7	1	2
R:R:D128	R:R:R143	7.15	4	No	No	8	7	1	2
R:R:D128	W:W:?1	6.08	4	No	Yes	8	0	1	0
R:R:Q132	R:R:R143	11.68	4	No	No	7	7	2	2
R:R:H142	R:R:W138	21.16	4	No	No	4	4	1	1
R:R:W138	W:W:?1	8.5	4	No	Yes	4	0	1	0
R:R:H142	R:R:N141	6.38	4	No	No	4	5	1	2
R:R:H142	W:W:?1	27.83	4	No	Yes	4	0	1	0
R:R:A147	W:W:?1	7.06	0	No	Yes	3	0	1	0
R:R:K150	W:W:?1	7.37	0	No	Yes	2	0	1	0
R:R:L131	W:W:?1	2.07	0	No	Yes	6	0	1	0
R:R:A147	R:R:T144	1.68	0	No	No	3	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XXU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	283
Number of Links	322
Number of Hubs	44
Number of Links mediated by Hubs	163
Number of Communities	7
Number of Nodes involved in Communities	54
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	54786
Length Of Smallest Path	3
Average Path Length	16.1123
Length of Longest Path	39
Minimum Path Strength	1.07
Average Path Strength	5.95482
Maximum Path Strength	17.6
Minimum Path Correlation	0.7
Average Path Correlation	0.938664
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	51.0369
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_W_
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5Y4
Sequence	>8XXU_nogp_Chain_R L C P I L E Q M S R L Q S H S N T S I R Y I D H A A V L L H G L A S L L G L V E N G V I L F V V G C R M R Q T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G H S W E L G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R P V W A Q N H R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D T I S D G R I M C Y Y N V L L L N P G P D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R G R R R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A H A N P G L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D M L R K L R R S L R T V L E S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-PGD2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	PGD2	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	PGD2	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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