psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E15	R:R:L10	3.98	No	No	0	7	7
2	R:R:C11	R:R:P12	3.77	Yes	No	1	7	6
3	R:R:C11	R:R:L187	3.17	Yes	No	0	7	4
4	R:R:C11	R:R:C199	7.28	Yes	No	0	7	2
5	R:R:C11	R:R:H273	2.95	Yes	Yes	1	7	1
6	R:R:P12	R:R:R195	2.88	No	No	0	6	2
7	R:R:H273	R:R:P12	3.05	Yes	No	1	1	6
8	R:R:I13	R:R:M17	4.37	No	Yes	1	7	7
9	R:R:I13	R:R:Y183	13.3	No	Yes	1	7	4
10	R:R:H273	R:R:I13	5.3	Yes	No	1	1	7
11	R:R:L14	R:R:S18	3	No	No	0	7	7
12	R:R:D171	R:R:L14	4.07	Yes	No	0	5	7
13	R:R:L14	R:R:Y183	8.21	No	Yes	0	7	4
14	R:R:E15	R:R:R195	4.65	No	No	0	7	2
15	R:R:Q16	R:R:R279	4.67	No	Yes	0	7	1
16	R:R:M17	R:R:Y183	8.38	Yes	Yes	1	7	4
17	R:R:E269	R:R:M17	2.71	No	Yes	0	5	7
18	R:R:M17	R:R:W283	5.82	Yes	Yes	0	7	4
19	R:R:R19	R:R:S18	6.59	No	No	0	5	7
20	R:R:L20	R:R:S22	3	No	No	0	5	4
21	R:R:L20	R:R:W283	11.39	No	Yes	0	5	4
22	R:R:H23	R:R:R179	5.64	No	No	0	5	1
23	R:R:S24	R:R:Y30	6.36	No	No	0	4	2
24	R:R:T26	R:R:Y30	7.49	No	No	0	3	2
25	R:R:H33	R:R:Y30	4.36	No	No	0	3	2
26	R:R:G178	R:R:V36	3.68	No	No	0	5	4
27	R:R:H39	R:R:S291	4.18	No	No	0	8	5
28	R:R:F294	R:R:H39	12.44	Yes	No	0	6	8
29	R:R:L41	R:R:L44	2.77	No	No	0	5	6
30	R:R:A42	R:R:F295	4.16	No	No	0	7	5
31	R:R:P85	R:R:S43	7.13	No	No	0	9	7
32	R:R:F86	R:R:L44	2.44	No	No	0	7	6
33	R:R:L47	R:R:L78	2.77	Yes	Yes	2	6	8
34	R:R:L47	R:R:S81	10.51	Yes	No	0	6	6
35	R:R:F86	R:R:L47	2.44	No	Yes	0	7	6
36	R:R:E49	R:R:V298	5.7	No	No	0	7	8
37	R:R:E49	R:R:P301	3.14	No	Yes	0	7	9
38	R:R:E49	R:R:V302	4.28	No	No	0	7	6
39	R:R:D77	R:R:N50	13.46	No	No	2	9	9
40	R:R:L78	R:R:N50	8.24	Yes	No	2	8	9
41	R:R:N50	R:R:P301	3.26	No	Yes	2	9	9
42	R:R:I53	R:R:V52	3.07	Yes	No	0	9	6
43	R:R:A74	R:R:I53	3.25	No	Yes	0	9	9
44	R:R:I53	R:R:P301	3.39	Yes	Yes	0	9	9
45	R:R:I53	R:R:V305	4.61	Yes	No	0	9	7
46	R:R:L54	R:R:L71	2.77	No	No	0	7	6
47	R:R:A74	R:R:L54	4.73	No	No	0	9	7
48	R:R:C59	R:R:F55	2.79	No	No	0	5	4
49	R:R:R60	R:R:V56	3.92	No	Yes	3	5	7
50	R:R:K314	R:R:V56	4.55	No	Yes	3	4	7
51	R:R:M61	R:R:V57	9.13	Yes	No	3	6	7
52	R:R:T67	R:R:V57	3.17	No	No	3	7	7
53	R:R:L71	R:R:V57	7.45	No	No	0	6	7
54	R:R:K314	R:R:R60	12.38	No	No	3	4	5
55	R:R:M61	R:R:T67	4.52	Yes	No	3	6	7
56	R:R:M311	R:R:M61	4.33	Yes	Yes	0	8	6
57	R:R:K314	R:R:M61	8.64	No	Yes	3	4	6
58	R:R:L71	R:R:Q63	3.99	No	No	0	6	5
59	R:R:T64	R:R:T67	10.99	No	No	0	7	7
60	R:R:V65	R:R:W69	3.68	No	Yes	0	5	7
61	R:R:R143	R:R:V65	10.46	No	No	0	7	5
62	R:R:H72	R:R:T68	2.74	Yes	No	0	9	7
63	R:R:H149	R:R:T68	10.95	No	No	0	4	7
64	R:R:A124	R:R:W69	5.19	No	Yes	0	7	7
65	R:R:I125	R:R:W69	8.22	No	Yes	0	8	7
66	R:R:A148	R:R:W69	3.89	No	Yes	0	7	7
67	R:R:V151	R:R:W69	3.68	No	Yes	0	5	7
68	R:R:C152	R:R:W69	5.22	No	Yes	0	7	7
69	R:R:M311	R:R:V70	6.09	Yes	No	0	8	8
70	R:R:H72	R:R:L121	2.57	Yes	No	0	9	7
71	R:R:C152	R:R:H72	14.74	No	Yes	0	7	9
72	R:R:H72	R:R:W156	3.17	Yes	Yes	0	9	9
73	R:R:L73	R:R:S118	3	Yes	No	0	9	9
74	R:R:L121	R:R:L73	2.77	No	Yes	0	7	9
75	R:R:L73	R:R:N300	2.75	Yes	No	0	9	9
76	R:R:L73	R:R:Y304	3.52	Yes	Yes	0	9	9
77	R:R:L75	R:R:L79	4.15	No	No	0	6	6
78	R:R:N114	R:R:S76	4.47	Yes	Yes	0	8	8
79	R:R:A117	R:R:S76	3.42	No	Yes	6	7	8
80	R:R:S118	R:R:S76	3.26	No	Yes	0	9	8
81	R:R:S76	R:R:W156	4.94	Yes	Yes	6	8	9
82	R:R:D77	R:R:S297	11.78	No	No	0	9	9
83	R:R:D77	R:R:P301	6.44	No	Yes	2	9	9
84	R:R:A80	R:R:N114	6.25	No	Yes	0	7	8
85	R:R:L84	R:R:S83	3	Yes	No	0	8	6
86	R:R:I110	R:R:S83	9.29	No	No	0	5	6
87	R:R:L84	R:R:P85	3.28	Yes	No	0	8	9
88	R:R:H107	R:R:L84	3.86	No	Yes	0	5	8
89	R:R:F111	R:R:L84	2.44	Yes	Yes	1	6	8
90	R:R:F294	R:R:L84	8.53	Yes	Yes	1	6	8
91	R:R:F103	R:R:T88	5.19	Yes	No	0	6	7
92	R:R:D177	R:R:Y89	17.24	No	No	0	3	4
93	R:R:F90	R:R:L91	6.09	No	No	0	5	5
94	R:R:F103	R:R:L91	8.53	Yes	No	0	6	5
95	R:R:E98	R:R:F103	9.33	No	Yes	0	3	6
96	R:R:K105	R:R:T101	3	Yes	No	0	7	4
97	R:R:D171	R:R:T101	4.34	Yes	No	0	5	4
98	R:R:K105	R:R:T102	4.5	Yes	No	0	7	3
99	R:R:C104	R:R:R170	5.57	No	Yes	1	9	5
100	R:R:C104	R:R:T172	10.14	No	No	0	9	6
101	R:R:C104	R:R:C182	7.28	No	No	1	9	9
102	R:R:F167	R:R:K105	2.48	No	Yes	0	4	7
103	R:R:K105	R:R:R170	4.95	Yes	Yes	0	7	5
104	R:R:I110	R:R:L106	7.14	No	No	0	5	4
105	R:R:C182	R:R:H107	10.32	No	No	0	9	5
106	R:R:F112	R:R:S108	6.61	Yes	No	0	5	5
107	R:R:R170	R:R:S108	15.81	Yes	No	0	5	5
108	R:R:F167	R:R:S109	7.93	No	No	0	4	5
109	R:R:I110	R:R:N114	5.66	No	Yes	0	5	8
110	R:R:F111	R:R:F112	4.29	Yes	Yes	1	6	5
111	R:R:F111	R:R:Y262	10.32	Yes	Yes	1	6	7
112	R:R:F111	R:R:T290	2.59	Yes	No	1	6	6
113	R:R:F111	R:R:F294	7.5	Yes	Yes	1	6	6
114	R:R:F112	R:R:M115	2.49	Yes	Yes	1	5	8
115	R:R:F112	R:R:T163	2.59	Yes	No	0	5	7
116	R:R:F112	R:R:Y166	13.41	Yes	Yes	1	5	4
117	R:R:F112	R:R:K210	4.96	Yes	Yes	1	5	5
118	R:R:F112	R:R:Y262	5.16	Yes	Yes	1	5	7
119	R:R:L113	R:R:W156	6.83	No	Yes	0	5	9
120	R:R:L113	R:R:V160	4.47	No	No	0	5	4
121	R:R:F116	R:R:M115	4.98	Yes	Yes	1	7	8
122	R:R:A214	R:R:M115	4.83	No	Yes	1	6	8
123	R:R:M115	R:R:W259	12.8	Yes	Yes	0	8	8
124	R:R:H263	R:R:M115	5.25	Yes	Yes	1	8	8
125	R:R:F116	R:R:F120	3.22	Yes	No	0	7	6
126	R:R:F116	R:R:T163	2.59	Yes	No	0	7	7
127	R:R:F116	R:R:K210	2.48	Yes	Yes	1	7	5
128	R:R:F116	R:R:L213	6.09	Yes	No	0	7	4
129	R:R:A214	R:R:F116	2.77	No	Yes	1	6	7
130	R:R:A117	R:R:W156	7.78	No	Yes	6	7	9
131	R:R:G119	R:R:P218	4.06	No	No	0	7	9
132	R:R:F120	R:R:L155	9.74	No	No	0	6	7
133	R:R:A159	R:R:F120	2.77	No	No	0	8	6
134	R:R:F255	R:R:L122	2.44	No	No	0	9	9
135	R:R:L122	R:R:N300	2.75	No	No	0	9	9
136	R:R:L122	R:R:Y304	5.86	No	Yes	0	9	9
137	R:R:P218	R:R:S123	3.56	No	No	0	9	7
138	R:R:I221	R:R:S123	4.64	Yes	No	0	7	7
139	R:R:S123	W:W:?1	2.62	No	Yes	0	7	0
140	R:R:I125	R:R:R129	6.26	No	No	5	8	9
141	R:R:I125	R:R:Y304	3.63	No	Yes	5	8	9
142	R:R:I222	R:R:S126	9.29	No	No	0	8	9
143	R:R:S126	R:R:S225	3.26	No	No	0	9	8
144	R:R:I221	R:R:L127	4.28	Yes	No	0	7	6
145	R:R:L127	W:W:?1	7.24	No	Yes	0	6	0
146	R:R:D128	R:R:Q132	10.44	No	No	4	8	7
147	R:R:D128	R:R:R143	7.15	No	No	4	8	7
148	R:R:D128	W:W:?1	7.1	No	Yes	4	8	0
149	R:R:R129	R:R:Y304	3.09	No	Yes	5	9	9
150	R:R:C130	R:R:S225	3.44	No	No	0	8	8
151	R:R:Q132	R:R:R143	11.68	No	No	4	7	7
152	R:R:V133	R:R:V229	12.83	No	No	0	8	8
153	R:R:R232	R:R:V133	2.62	No	No	0	5	8
154	R:R:R135	R:R:V134	5.23	No	No	0	6	8
155	R:R:R232	R:R:V134	9.15	No	No	0	5	8
156	R:R:N141	R:R:V137	4.43	No	No	0	5	6
157	R:R:H142	R:R:W138	21.16	No	No	4	4	4
158	R:R:W138	W:W:?1	9.93	No	Yes	4	4	0
159	R:R:H142	R:R:N141	6.38	No	No	0	4	5
160	R:R:H142	W:W:?1	32.51	No	Yes	4	4	0
161	R:R:H149	R:R:V145	2.77	No	No	0	4	1
162	R:R:A147	W:W:?1	8.24	No	Yes	0	3	0
163	R:R:K150	W:W:?1	8.61	No	Yes	0	2	0
164	R:R:L155	R:R:V151	2.98	No	No	0	7	5
165	R:R:V151	W:W:?1	2.6	No	Yes	0	5	0
166	R:R:L158	R:R:V154	2.98	No	No	0	5	3
167	R:R:T163	R:R:V160	3.17	No	No	0	7	4
168	R:R:L213	R:R:N162	9.61	No	No	0	4	5
169	R:R:P165	R:R:V164	3.53	No	No	0	7	4
170	R:R:Y166	R:R:Y184	9.93	Yes	Yes	1	4	4
171	R:R:L206	R:R:Y166	14.07	Yes	Yes	1	5	4
172	R:R:S209	R:R:Y166	6.36	No	Yes	0	4	4
173	R:R:K210	R:R:Y166	7.17	Yes	Yes	1	5	4
174	R:R:F169	R:R:V168	11.8	No	No	0	5	4
175	R:R:L189	R:R:V168	4.47	No	No	0	5	4
176	R:R:F169	R:R:V186	22.28	No	No	0	5	5
177	R:R:F169	R:R:L206	2.44	No	Yes	0	5	5
178	R:R:C182	R:R:R170	5.57	No	Yes	1	9	5
179	R:R:R170	R:R:Y184	15.43	Yes	Yes	1	5	4
180	R:R:D171	R:R:N185	6.73	Yes	No	0	5	4
181	R:R:D171	R:R:L188	4.07	Yes	No	0	5	7
182	R:R:M181	R:R:T172	3.01	No	No	0	4	6
183	R:R:I173	R:R:S174	3.1	No	No	0	3	1
184	R:R:D177	R:R:G178	6.71	No	No	0	3	5
185	R:R:Y183	R:R:Y184	2.98	Yes	Yes	1	4	4
186	R:R:N185	R:R:Y183	3.49	No	Yes	0	4	4
187	R:R:Q203	R:R:Y184	16.91	No	Yes	0	3	4
188	R:R:L206	R:R:Y184	11.72	Yes	Yes	1	5	4
189	R:R:L187	R:R:N185	10.98	No	No	0	4	4
190	R:R:R202	R:R:V186	11.77	No	No	0	3	5
191	R:R:N190	R:R:R202	4.82	No	No	0	7	3
192	R:R:G192	R:R:P193	4.06	No	No	0	5	5
193	R:R:A197	R:R:D194	4.63	No	No	0	1	1
194	R:R:D194	R:R:T198	5.78	No	No	0	1	3
195	R:R:D196	R:R:H273	8.82	No	Yes	0	2	1
196	R:R:N200	R:R:V204	4.43	No	No	0	1	2
197	R:R:H273	R:R:N200	16.58	Yes	No	0	1	1
198	R:R:L212	R:R:V208	2.98	No	No	0	6	4
199	R:R:K210	R:R:Y262	7.17	Yes	Yes	1	5	7
200	R:R:H263	R:R:K210	9.17	Yes	Yes	1	8	5
201	R:R:K210	R:R:S266	7.65	Yes	No	0	5	5
202	R:R:F211	R:R:L212	3.65	Yes	No	1	6	6
203	R:R:F211	R:R:F215	9.65	Yes	Yes	1	6	9
204	R:R:F211	R:R:L216	8.53	Yes	No	1	6	5
205	R:R:F211	R:R:H263	9.05	Yes	Yes	1	6	8
206	R:R:L212	R:R:L216	4.15	No	No	1	6	5
207	R:R:A214	R:R:H263	2.93	No	Yes	1	6	8
208	R:R:F215	R:R:L219	3.65	Yes	No	0	9	5
209	R:R:F215	R:R:G260	6.02	Yes	No	0	9	5
210	R:R:F215	R:R:H263	3.39	Yes	Yes	1	9	8
211	R:R:P218	R:R:V217	3.53	No	No	0	9	5
212	R:R:I221	R:R:V217	3.07	Yes	No	0	7	5
213	R:R:F255	R:R:L219	3.65	No	No	0	9	5
214	R:R:I221	R:R:S224	3.1	Yes	No	0	7	4
215	R:R:H226	R:R:I222	5.3	No	No	0	9	8
216	R:R:H226	R:R:V248	16.61	No	No	0	9	7
217	R:R:L233	R:R:V229	2.98	No	No	0	8	8
218	R:R:F244	R:R:V229	3.93	Yes	No	0	7	8
219	R:R:F244	R:R:S230	5.28	Yes	No	0	7	5
220	R:R:H235	R:R:L231	3.86	No	No	0	4	4
221	R:R:L233	R:R:R238	4.86	No	No	0	8	3
222	R:R:L233	R:R:R240	8.5	No	Yes	0	8	5
223	R:R:Q234	R:R:R240	8.18	No	Yes	0	5	5
224	R:R:R238	R:R:R239	6.4	No	No	0	3	4
225	R:R:F244	R:R:R240	4.28	Yes	Yes	7	7	5
226	R:R:R243	R:R:R246	5.33	No	No	0	7	5
227	R:R:F244	R:R:V248	6.55	Yes	No	0	7	7
228	R:R:L247	R:R:T307	4.42	No	No	0	7	7
229	R:R:A250	R:R:L303	3.15	No	No	0	6	8
230	R:R:V251	R:R:Y304	8.83	No	Yes	0	8	9
231	R:R:F255	R:R:W259	13.03	No	Yes	0	9	8
232	R:R:C258	R:R:N296	7.87	No	No	0	8	9
233	R:R:A293	R:R:W259	3.89	No	Yes	0	8	8
234	R:R:N296	R:R:W259	14.69	No	Yes	0	9	8
235	R:R:G260	R:R:P261	4.06	No	No	0	5	9
236	R:R:P261	R:R:V289	3.53	No	No	0	9	7
237	R:R:H263	R:R:Y262	5.44	Yes	Yes	1	8	7
238	R:R:L268	R:R:V264	2.98	No	No	0	5	6
239	R:R:F265	R:R:G285	4.52	No	No	0	5	5
240	R:R:F265	R:R:V289	5.24	No	No	0	5	7
241	R:R:E269	R:R:V282	8.56	No	No	0	5	4
242	R:R:P276	R:R:R279	5.76	No	Yes	0	1	1
243	R:R:R279	R:R:W283	3	Yes	Yes	0	1	4
244	R:R:L286	R:R:P287	3.28	No	No	0	5	4
245	R:R:F294	R:R:T290	5.19	Yes	No	1	6	6
246	R:R:F295	R:R:S291	3.96	No	No	0	5	5
247	R:R:N296	R:R:N300	14.98	No	No	0	9	9
248	R:R:L306	R:R:V305	2.98	No	No	0	7	7
249	R:R:L306	R:R:L312	2.77	No	No	0	7	7
250	R:R:C308	R:R:M311	4.86	No	Yes	0	8	8
251	R:R:D310	R:R:P309	3.22	No	No	0	5	5
252	R:R:D310	R:R:M311	6.93	No	Yes	0	5	8
253	R:R:R313	R:R:R317	26.66	No	No	0	5	4
254	R:R:L319	R:R:R316	3.64	No	No	0	7	5
255	R:R:R316	R:R:R320	3.2	No	No	0	5	5
256	R:R:S318	R:R:T321	3.2	No	No	0	4	3
257	R:R:L319	R:R:L323	2.77	No	No	0	7	5
258	R:R:L323	R:R:R320	7.29	No	No	0	5	5
259	R:R:E324	R:R:S325	4.31	No	No	0	4	5
260	R:R:L131	W:W:?1	2.41	No	Yes	0	6	0
261	R:R:G192	R:R:P191	2.03	No	No	0	5	6
262	R:R:G242	R:R:P241	2.03	No	No	0	5	6
263	R:R:G285	R:R:P287	2.03	No	No	0	5	4
264	R:R:G40	R:R:S43	1.86	No	No	0	4	7
265	R:R:G100	R:R:S174	1.86	Yes	No	0	8	1
266	R:R:G46	R:R:V298	1.84	No	No	0	8	8
267	R:R:G242	R:R:V245	1.84	No	No	0	5	5
268	R:R:G100	R:R:T172	1.82	Yes	No	0	8	6
269	R:R:G192	R:R:T198	1.82	No	No	0	5	3
270	R:R:A228	R:R:C130	1.81	No	No	0	3	8
271	R:R:A254	R:R:A299	1.79	No	No	0	7	6
272	R:R:G46	R:R:L45	1.71	No	No	0	8	6
273	R:R:G51	R:R:L78	1.71	No	Yes	0	5	8
274	R:R:C308	R:R:V66	1.71	No	No	0	8	7
275	R:R:A80	R:R:S297	1.71	No	No	0	7	9
276	R:R:G100	R:R:L99	1.71	Yes	No	0	8	7
277	R:R:A207	R:R:S266	1.71	No	No	0	5	5
278	R:R:A270	R:R:V204	1.7	No	No	0	5	2
279	R:R:C308	R:R:T307	1.69	No	No	0	8	7
280	R:R:A146	R:R:T144	1.68	No	No	0	4	6
281	R:R:A147	R:R:T144	1.68	No	No	0	3	6
282	R:R:L206	R:R:P165	1.64	Yes	No	0	5	7
283	R:R:N190	R:R:P191	1.63	No	No	0	7	6
284	R:R:S224	R:R:S225	1.63	No	No	0	4	8
285	R:R:N275	R:R:P276	1.63	No	No	0	2	1
286	R:R:S318	R:R:V56	1.62	No	Yes	0	4	7
287	R:R:S318	R:R:V322	1.62	No	No	0	4	4
288	R:R:V248	R:R:V252	1.6	No	No	0	7	8
289	R:R:A82	R:R:L47	1.58	No	Yes	2	5	6
290	R:R:A82	R:R:L78	1.58	No	Yes	2	5	8
291	R:R:A207	R:R:L267	1.58	No	No	0	5	6
292	R:R:A254	R:R:L303	1.58	No	No	0	7	8
293	R:R:A272	R:R:L278	1.58	No	No	0	3	1
294	R:R:A274	R:R:N275	1.56	No	No	0	1	2
295	R:R:A139	R:R:Q132	1.52	No	No	0	5	7
296	R:R:F103	R:R:G100	1.51	Yes	Yes	0	6	8
297	R:R:F288	R:R:G285	1.51	No	No	0	5	5
298	R:R:L91	R:R:S96	1.5	No	No	0	5	4
299	R:R:G242	R:R:R246	1.5	No	No	0	5	5
300	R:R:L315	R:R:V52	1.49	No	No	0	5	6
301	R:R:L315	R:R:V56	1.49	No	Yes	0	5	7
302	R:R:L268	R:R:V282	1.49	No	No	0	5	4
303	R:R:L327	R:R:V326	1.49	No	No	0	4	5
304	R:R:D32	R:R:V36	1.46	No	No	0	4	4
305	R:R:P136	R:R:R135	1.44	No	No	0	8	6
306	R:R:P241	R:R:R240	1.44	No	Yes	7	6	5
307	R:R:F244	R:R:P241	1.44	Yes	No	7	7	6
308	R:R:P280	R:R:R279	1.44	No	Yes	0	2	1
309	R:R:H23	R:R:S22	1.39	No	No	0	5	4
310	R:R:A272	R:R:R279	1.38	No	Yes	0	3	1
311	R:R:L278	R:R:L281	1.38	No	No	0	1	2
312	R:R:L79	R:R:N114	1.37	No	Yes	0	6	8
313	R:R:L158	R:R:N162	1.37	No	No	0	5	5
314	R:R:L231	R:R:Q234	1.33	No	No	0	4	5
315	R:R:R284	R:R:S22	1.32	No	No	0	1	4
316	R:R:R202	R:R:S201	1.32	No	No	0	3	1
317	R:R:R317	R:R:T321	1.29	No	No	0	4	3
318	R:R:D32	R:R:H33	1.26	No	No	0	4	3
319	R:R:S96	R:R:W97	1.24	No	No	0	4	9
320	R:R:L303	R:R:Y304	1.17	No	Yes	0	8	9
321	R:R:E324	R:R:R320	1.16	No	No	0	4	5
322	R:R:Q21	R:R:W283	1.1	No	Yes	0	5	4
323	R:R:R232	R:R:R236	1.07	No	No	0	5	5
324	R:R:R236	R:R:R238	1.07	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C11	4.2925	4	1	7
2	R:R:M17	5.32	4	1	7
3	R:R:L47	4.325	4	2	6
4	R:R:I53	3.58	4	0	9
5	R:R:V56	2.895	4	3	7
6	R:R:M61	6.655	4	3	6
7	R:R:W69	4.98	6	0	7
8	R:R:H72	5.805	4	0	9
9	R:R:L73	3.01	4	0	9
10	R:R:S76	4.0225	4	6	8
11	R:R:L78	3.575	4	2	8
12	R:R:L84	4.222	5	1	8
13	R:R:G100	1.725	4	0	8
14	R:R:F103	6.14	4	0	6
15	R:R:K105	3.7325	4	0	7
16	R:R:F111	5.428	5	1	6
17	R:R:F112	5.64429	7	1	5
18	R:R:N114	4.4375	4	0	8
19	R:R:M115	6.07	5	1	8
20	R:R:F116	3.68833	6	1	7
21	R:R:W156	5.68	4	6	9
22	R:R:Y166	10.188	5	1	4
23	R:R:R170	9.466	5	1	5
24	R:R:D171	4.8025	4	0	5
25	R:R:Y183	7.272	5	1	4
26	R:R:Y184	11.394	5	1	4
27	R:R:L206	7.4675	4	1	5
28	R:R:K210	6.43333	6	1	5
29	R:R:F211	7.72	4	1	6
30	R:R:F215	5.6775	4	1	9
31	R:R:I221	3.7725	4	0	7
32	R:R:R240	5.6	4	7	5
33	R:R:F244	4.296	5	7	7
34	R:R:W259	11.1025	4	0	8
35	R:R:Y262	7.0225	4	1	7
36	R:R:H263	5.87167	6	1	8
37	R:R:H273	7.34	5	1	1
38	R:R:R279	3.25	5	0	1
39	R:R:W283	5.3275	4	0	4
40	R:R:F294	8.415	4	1	6
41	R:R:P301	4.0575	4	2	9
42	R:R:Y304	4.35	6	5	9
43	R:R:M311	5.5525	4	0	8
44	W:W:?1	9.02889	9	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H273	R:R:I13	12.3322	5.3	Yes	No	1	1	7
2	R:R:I13	R:R:Y183	12.6827	13.3	No	Yes	1	7	4
3	R:R:M17	R:R:W283	17.8003	5.82	Yes	Yes	0	7	4
4	R:R:R279	R:R:W283	10.2887	3	Yes	Yes	0	1	4
5	R:R:Y183	R:R:Y184	44.4517	2.98	Yes	Yes	1	4	4
6	R:R:Y166	R:R:Y184	40.6647	9.93	Yes	Yes	1	4	4
7	R:R:F112	R:R:Y166	20.1794	13.41	Yes	Yes	1	5	4
8	R:R:F111	R:R:F112	28.8167	4.29	Yes	Yes	1	6	5
9	R:R:F111	R:R:L84	26.3811	2.44	Yes	Yes	1	6	8
10	R:R:L84	R:R:S83	33.5541	3	Yes	No	0	8	6
11	R:R:I110	R:R:S83	32.4017	9.29	No	No	0	5	6
12	R:R:I110	R:R:N114	32.3007	5.66	No	Yes	0	5	8
13	R:R:A80	R:R:N114	53.3028	6.25	No	Yes	0	7	8
14	R:R:A80	R:R:S297	52.5306	1.71	No	No	0	7	9
15	R:R:D77	R:R:S297	51.7524	11.78	No	No	0	9	9
16	R:R:R170	R:R:Y184	20.2358	15.43	Yes	Yes	1	5	4
17	R:R:C182	R:R:R170	12.1035	5.57	No	Yes	1	9	5
18	R:R:C182	R:R:H107	14.0341	10.32	No	No	0	9	5
19	R:R:H107	R:R:L84	15.5192	3.86	No	Yes	0	5	8
20	R:R:D77	R:R:P301	42.4409	6.44	No	Yes	2	9	9
21	R:R:I53	R:R:P301	38.4935	3.39	Yes	Yes	0	9	9
22	R:R:I53	R:R:V52	19.0091	3.07	Yes	No	0	9	6
23	R:R:A74	R:R:I53	16.0657	3.25	No	Yes	0	9	9
24	R:R:A74	R:R:L54	15.0796	4.73	No	No	0	9	7
25	R:R:L54	R:R:L71	14.1143	2.77	No	No	0	7	6
26	R:R:L315	R:R:V52	18.0528	1.49	No	No	0	5	6
27	R:R:L315	R:R:V56	17.1676	1.49	No	Yes	0	5	7
28	R:R:K314	R:R:V56	10.3451	4.55	No	Yes	3	4	7
29	R:R:L71	R:R:V57	12.2074	7.45	No	No	0	6	7
30	R:R:M311	R:R:M61	16.3627	4.33	Yes	Yes	0	8	6
31	R:R:K210	R:R:Y166	32.9512	7.17	Yes	Yes	1	5	4
32	R:R:F116	R:R:K210	49.9228	2.48	Yes	Yes	1	7	5
33	R:R:F116	R:R:F120	80.9552	3.22	Yes	No	0	7	6
34	R:R:F120	R:R:L155	79.5711	9.74	No	No	0	6	7
35	R:R:L155	R:R:V151	79.2711	2.98	No	No	0	7	5
36	R:R:V151	R:R:W69	30.0493	3.68	No	Yes	0	5	7
37	R:R:V151	W:W:?1	100	2.6	No	Yes	0	5	0
38	R:R:F112	R:R:T163	16.2469	2.59	Yes	No	0	5	7
39	R:R:H72	R:R:W156	23.8535	3.17	Yes	Yes	0	9	9
40	R:R:F112	R:R:M115	19.4814	2.49	Yes	Yes	1	5	8
41	R:R:C152	R:R:W69	22.1219	5.22	No	Yes	0	7	7
42	R:R:C152	R:R:H72	22.0625	14.74	No	Yes	0	7	9
43	R:R:S76	R:R:W156	23.3605	4.94	Yes	Yes	6	8	9
44	R:R:C104	R:R:R170	24.9881	5.57	No	Yes	1	9	5
45	R:R:C104	R:R:T172	26.3306	10.14	No	No	0	9	6
46	R:R:G100	R:R:T172	22.3447	1.82	Yes	No	0	8	6
47	R:R:F103	R:R:G100	14.3014	1.51	Yes	Yes	0	6	8
48	R:R:K105	R:R:R170	10.8412	4.95	Yes	Yes	0	7	5
49	R:R:R170	R:R:S108	25.7069	15.81	Yes	No	0	5	5
50	R:R:H263	R:R:K210	10.4669	9.17	Yes	Yes	1	8	5
51	R:R:S123	W:W:?1	46.3734	2.62	No	Yes	0	7	0
52	R:R:I221	R:R:S123	42.1765	4.64	Yes	No	0	7	7
53	R:R:L127	W:W:?1	42.9191	7.24	No	Yes	0	6	0
54	R:R:I221	R:R:L127	41.9003	4.28	Yes	No	0	7	6
55	R:R:I221	R:R:S224	79.9899	3.1	Yes	No	0	7	4
56	R:R:S224	R:R:S225	77.7979	1.63	No	No	0	4	8
57	R:R:S126	R:R:S225	71.1863	3.26	No	No	0	9	8
58	R:R:I222	R:R:S126	68.9705	9.29	No	No	0	8	9
59	R:R:H226	R:R:I222	66.7488	5.3	No	No	0	9	8
60	R:R:H226	R:R:V248	64.5153	16.61	No	No	0	9	7
61	R:R:F244	R:R:V248	60.1877	6.55	Yes	No	0	7	7
62	R:R:F244	R:R:V229	25.6148	3.93	Yes	No	0	7	8
63	R:R:V133	R:R:V229	14.0608	12.83	No	No	0	8	8
64	R:R:R232	R:R:V133	11.8213	2.62	No	No	0	5	8
65	R:R:F169	R:R:L206	12.1956	2.44	No	Yes	0	5	5
66	R:R:F215	R:R:H263	16.2172	3.39	Yes	Yes	1	9	8
67	R:R:F215	R:R:G260	14.8004	6.02	Yes	No	0	9	5
68	R:R:F244	R:R:R240	18.6735	4.28	Yes	Yes	7	7	5
69	R:R:L233	R:R:R238	14.1143	4.86	No	No	0	8	3
70	R:R:F244	R:R:P241	11.7144	1.44	Yes	No	7	7	6
71	R:R:G260	R:R:P261	12.9708	4.06	No	No	0	5	9
72	R:R:P261	R:R:V289	11.1352	3.53	No	No	0	9	7
73	R:R:M17	R:R:Y183	22.2823	8.38	Yes	Yes	1	7	4
74	R:R:F112	R:R:S108	26.9603	6.61	Yes	No	0	5	5
75	R:R:N114	R:R:S76	27.1534	4.47	Yes	Yes	0	8	8
76	R:R:F116	R:R:M115	18.1329	4.98	Yes	Yes	1	7	8
77	R:R:F116	R:R:T163	14.8153	2.59	Yes	No	0	7	7
78	R:R:F112	R:R:K210	14.2509	4.96	Yes	Yes	1	5	5
79	R:R:L206	R:R:Y166	11.5451	14.07	Yes	Yes	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V151	R:R:W69	3.68	0	No	Yes	5	7	1	2
R:R:P218	R:R:S123	3.56	0	No	No	9	7	2	1
R:R:I221	R:R:S123	4.64	0	Yes	No	7	7	2	1
R:R:S123	W:W:?1	2.62	0	No	Yes	7	0	1	0
R:R:I221	R:R:L127	4.28	0	Yes	No	7	6	2	1
R:R:L127	W:W:?1	7.24	0	No	Yes	6	0	1	0
R:R:D128	R:R:Q132	10.44	4	No	No	8	7	1	2
R:R:D128	R:R:R143	7.15	4	No	No	8	7	1	2
R:R:D128	W:W:?1	7.1	4	No	Yes	8	0	1	0
R:R:Q132	R:R:R143	11.68	4	No	No	7	7	2	2
R:R:H142	R:R:W138	21.16	4	No	No	4	4	1	1
R:R:W138	W:W:?1	9.93	4	No	Yes	4	0	1	0
R:R:H142	R:R:N141	6.38	4	No	No	4	5	1	2
R:R:H142	W:W:?1	32.51	4	No	Yes	4	0	1	0
R:R:A147	W:W:?1	8.24	0	No	Yes	3	0	1	0
R:R:K150	W:W:?1	8.61	0	No	Yes	2	0	1	0
R:R:L155	R:R:V151	2.98	0	No	No	7	5	2	1
R:R:V151	W:W:?1	2.6	0	No	Yes	5	0	1	0
R:R:L131	W:W:?1	2.41	0	No	Yes	6	0	1	0
R:R:A147	R:R:T144	1.68	0	No	No	3	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XXU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	283
Number of Links	324
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	7
Number of Nodes involved in Communities	54
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	69700
Length Of Smallest Path	3
Average Path Length	16.1698
Length of Longest Path	37
Minimum Path Strength	1.07
Average Path Strength	5.73372
Maximum Path Strength	20.56
Minimum Path Correlation	0.7
Average Path Correlation	0.939013
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.2509
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.0957
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of signaling • immune response • immune system process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • multicellular organismal process • negative regulation of male germ cell proliferation • sexual reproduction • regulation of reproductive process • reproductive process • regulation of male germ cell proliferation • negative regulation of biological process • gamete generation • germ cell proliferation • regulation of germ cell proliferation • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of cell population proliferation • cell population proliferation • multicellular organismal reproductive process • male germ cell proliferation • negative regulation of reproductive process • regulation of cell population proliferation • negative regulation of multicellular organismal process • negative regulation of germ cell proliferation • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to prostaglandin E • cellular response to forskolin • response to forskolin • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cellular response to prostaglandin E stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5Y4
Sequence	>8XXU_nogp_Chain_R L C P I L E Q M S R L Q S H S N T S I R Y I D H A A V L L H G L A S L L G L V E N G V I L F V V G C R M R Q T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G H S W E L G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R P V W A Q N H R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D T I S D G R I M C Y Y N V L L L N P G P D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R G R R R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A H A N P G L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D M L R K L R R S L R T V L E S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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