psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	12.02	Yes	No	0	0	6
2	L:L:?1	R:R:F90	25.63	Yes	No	0	0	5
3	L:L:?1	R:R:H107	10.15	Yes	Yes	1	0	5
4	L:L:?1	R:R:F111	6.41	Yes	Yes	1	0	6
5	L:L:?1	R:R:F112	7.21	Yes	Yes	1	0	5
6	L:L:?1	R:R:R170	7.99	Yes	Yes	1	0	5
7	L:L:?1	R:R:M181	20.46	Yes	Yes	1	0	4
8	L:L:?1	R:R:C182	5.22	Yes	No	0	0	9
9	L:L:?1	R:R:Y183	4.63	Yes	Yes	1	0	4
10	L:L:?1	R:R:Y184	17.73	Yes	No	1	0	4
11	R:R:L10	R:R:L14	6.92	No	No	1	7	7
12	R:R:E15	R:R:L10	6.63	No	No	0	7	7
13	R:R:I173	R:R:L10	5.71	No	No	1	3	7
14	R:R:C11	R:R:L14	4.76	No	No	0	7	7
15	R:R:C11	R:R:C199	5.46	No	No	0	7	2
16	R:R:D196	R:R:P12	8.05	No	No	0	2	6
17	R:R:E269	R:R:I13	4.1	No	No	0	5	7
18	R:R:H273	R:R:I13	14.58	No	No	0	1	7
19	R:R:I13	R:R:R279	3.76	No	Yes	0	7	1
20	R:R:I173	R:R:L14	8.56	No	No	1	3	7
21	R:R:Q16	R:R:R279	11.68	No	Yes	0	7	1
22	R:R:Q16	R:R:W283	6.57	No	No	0	7	4
23	R:R:M17	R:R:Y183	8.38	No	Yes	0	7	4
24	R:R:M17	R:R:W283	16.29	No	No	0	7	4
25	R:R:L20	R:R:R179	8.5	No	Yes	0	5	1
26	R:R:D32	R:R:I31	7	No	No	0	4	4
27	R:R:H33	R:R:L37	12.86	No	No	0	3	5
28	R:R:H39	R:R:L84	5.14	No	No	0	8	8
29	R:R:H39	R:R:T88	9.58	No	No	0	8	7
30	R:R:H39	R:R:S291	12.55	No	No	0	8	5
31	R:R:L41	R:R:L45	6.92	No	No	0	5	6
32	R:R:A42	R:R:F295	9.71	No	No	0	7	5
33	R:R:L84	R:R:S43	9.01	No	Yes	0	8	7
34	R:R:P85	R:R:S43	5.34	No	Yes	0	9	7
35	R:R:G46	R:R:S81	3.71	No	No	0	8	6
36	R:R:E49	R:R:P301	7.86	No	No	0	7	9
37	R:R:A74	R:R:N50	4.69	No	No	0	9	9
38	R:R:D77	R:R:N50	10.77	Yes	No	0	9	9
39	R:R:I53	R:R:V305	9.22	Yes	No	0	9	7
40	R:R:S318	R:R:V56	4.85	No	Yes	0	4	7
41	R:R:M61	R:R:V57	4.56	No	No	0	6	7
42	R:R:L71	R:R:V57	7.45	Yes	No	0	6	7
43	R:R:G58	R:R:L71	5.13	No	Yes	0	4	6
44	R:R:K314	R:R:R60	3.71	No	No	0	4	5
45	R:R:R60	R:R:S318	10.54	No	No	0	5	4
46	R:R:K314	R:R:M61	11.52	No	No	0	4	6
47	R:R:Q63	R:R:T67	5.67	No	No	0	5	7
48	R:R:L71	R:R:Q63	3.99	Yes	No	0	6	5
49	R:R:T64	R:R:T67	7.85	No	No	0	7	7
50	R:R:V65	R:R:W69	4.9	No	Yes	0	5	7
51	R:R:R143	R:R:V65	10.46	No	No	0	7	5
52	R:R:A148	R:R:V65	5.09	No	No	0	7	5
53	R:R:H149	R:R:T68	17.8	No	No	0	4	7
54	R:R:A124	R:R:W69	5.19	No	Yes	0	7	7
55	R:R:I125	R:R:W69	5.87	No	Yes	2	8	7
56	R:R:D128	R:R:W69	5.58	Yes	Yes	2	8	7
57	R:R:C152	R:R:W69	6.53	No	Yes	0	7	7
58	R:R:W69	W:W:?1	6.59	Yes	Yes	2	7	0
59	R:R:V305	R:R:V70	8.02	No	No	0	7	8
60	R:R:M311	R:R:V70	4.56	No	No	0	8	8
61	R:R:H149	R:R:H72	5.97	No	No	0	4	9
62	R:R:C152	R:R:H72	13.27	No	No	0	7	9
63	R:R:H72	R:R:W156	4.23	No	No	0	9	9
64	R:R:D77	R:R:L73	4.07	Yes	Yes	3	9	9
65	R:R:L121	R:R:L73	4.15	No	Yes	3	7	9
66	R:R:L73	R:R:N300	8.24	Yes	Yes	3	9	9
67	R:R:D77	R:R:S297	5.89	Yes	No	0	9	9
68	R:R:D77	R:R:N300	6.73	Yes	Yes	3	9	9
69	R:R:L79	R:R:N114	6.87	No	No	0	6	8
70	R:R:A80	R:R:N114	6.25	No	No	0	7	8
71	R:R:H107	R:R:S83	9.76	Yes	No	0	5	6
72	R:R:F294	R:R:L84	19.49	No	No	0	6	8
73	R:R:F103	R:R:F86	16.08	Yes	No	1	6	7
74	R:R:F86	R:R:H107	4.53	No	Yes	1	7	5
75	R:R:F87	R:R:L91	12.18	No	Yes	0	6	5
76	R:R:F90	R:R:L91	3.65	No	Yes	0	5	5
77	R:R:F90	R:R:W97	9.02	No	Yes	0	5	9
78	R:R:H95	R:R:L91	7.71	No	Yes	0	4	5
79	R:R:E98	R:R:V93	7.13	No	No	0	3	4
80	R:R:R179	R:R:S96	7.91	Yes	No	0	1	4
81	R:R:I180	R:R:S96	6.19	No	No	0	5	4
82	R:R:L99	R:R:W97	22.78	No	Yes	1	7	9
83	R:R:F103	R:R:W97	6.01	Yes	Yes	1	6	9
84	R:R:C104	R:R:W97	3.92	No	Yes	0	9	9
85	R:R:I180	R:R:W97	10.57	No	Yes	0	5	9
86	R:R:F103	R:R:L99	8.53	Yes	No	1	6	7
87	R:R:F103	R:R:H107	4.53	Yes	Yes	1	6	5
88	R:R:C104	R:R:R170	5.57	No	Yes	0	9	5
89	R:R:C104	R:R:C182	7.28	No	No	0	9	9
90	R:R:F167	R:R:K105	18.61	No	No	0	4	7
91	R:R:K105	R:R:R170	3.71	No	Yes	0	7	5
92	R:R:R170	R:R:S108	15.81	Yes	No	0	5	5
93	R:R:F167	R:R:S109	6.61	No	No	0	4	5
94	R:R:F111	R:R:F112	9.65	Yes	Yes	1	6	5
95	R:R:F111	R:R:Y262	8.25	Yes	Yes	0	6	7
96	R:R:F111	R:R:F294	11.79	Yes	No	0	6	6
97	R:R:F112	R:R:R170	5.34	Yes	Yes	1	5	5
98	R:R:F112	R:R:K210	4.96	Yes	Yes	0	5	5
99	R:R:L113	R:R:T163	4.42	No	No	0	5	7
100	R:R:F116	R:R:M115	4.98	Yes	Yes	4	7	8
101	R:R:A214	R:R:M115	4.83	No	Yes	4	6	8
102	R:R:M115	R:R:W259	12.8	Yes	Yes	0	8	8
103	R:R:H263	R:R:M115	5.25	No	Yes	0	8	8
104	R:R:F116	R:R:F120	4.29	Yes	No	0	7	6
105	R:R:F116	R:R:N162	10.87	Yes	No	0	7	5
106	R:R:A214	R:R:F116	4.16	No	Yes	4	6	7
107	R:R:A117	R:R:W156	7.78	No	No	0	7	9
108	R:R:G119	R:R:S118	3.71	No	No	0	7	9
109	R:R:S118	R:R:W259	3.71	No	Yes	0	9	8
110	R:R:G119	R:R:P218	4.06	No	No	0	7	9
111	R:R:F120	R:R:L155	4.87	No	No	0	6	7
112	R:R:L122	R:R:N300	4.12	No	Yes	0	9	9
113	R:R:L122	R:R:Y304	8.21	No	Yes	0	9	9
114	R:R:I221	R:R:S123	4.64	No	No	0	7	7
115	R:R:S123	W:W:?1	5.43	No	Yes	0	7	0
116	R:R:I125	R:R:R129	6.26	No	No	2	8	9
117	R:R:I125	R:R:Y304	6.04	No	Yes	2	8	9
118	R:R:I222	R:R:S126	10.84	No	No	0	8	9
119	R:R:I221	R:R:L127	4.28	No	No	0	7	6
120	R:R:L127	W:W:?1	8.01	No	Yes	0	6	0
121	R:R:D128	R:R:Q132	3.92	Yes	No	2	8	7
122	R:R:D128	R:R:R143	10.72	Yes	No	2	8	7
123	R:R:D128	W:W:?1	3.93	Yes	Yes	2	8	0
124	R:R:R129	R:R:Y304	7.2	No	Yes	2	9	9
125	R:R:L131	R:R:W138	4.56	No	No	0	6	4
126	R:R:Q132	R:R:R143	11.68	No	No	2	7	7
127	R:R:V133	R:R:V229	4.81	No	No	0	8	8
128	R:R:R135	R:R:V134	5.23	No	No	0	6	8
129	R:R:N141	R:R:V137	4.43	No	No	0	5	6
130	R:R:H142	R:R:W138	20.1	No	No	2	4	4
131	R:R:W138	W:W:?1	10.71	No	Yes	2	4	0
132	R:R:H142	W:W:?1	26.05	No	Yes	2	4	0
133	R:R:A147	W:W:?1	6.84	No	Yes	0	3	0
134	R:R:K150	W:W:?1	8.16	No	Yes	0	2	0
135	R:R:V151	W:W:?1	18.32	No	Yes	0	5	0
136	R:R:V154	W:W:?1	6.47	No	Yes	0	3	0
137	R:R:L155	W:W:?1	7.01	No	Yes	0	7	0
138	R:R:L161	R:R:N162	4.12	No	No	0	4	5
139	R:R:L206	R:R:Y166	8.21	No	No	0	5	4
140	R:R:K210	R:R:Y166	5.97	Yes	No	0	5	4
141	R:R:F169	R:R:V168	5.24	No	No	0	5	4
142	R:R:F169	R:R:R202	6.41	No	Yes	0	5	3
143	R:R:F169	R:R:L206	3.65	No	No	0	5	5
144	R:R:D171	R:R:N185	4.04	No	No	0	5	4
145	R:R:I180	R:R:T172	7.6	No	No	0	5	6
146	R:R:I173	R:R:M181	4.37	No	Yes	1	3	4
147	R:R:D177	R:R:R175	7.15	No	No	0	3	1
148	R:R:R175	R:R:R179	22.39	No	Yes	0	1	1
149	R:R:M181	R:R:R179	4.96	Yes	Yes	0	4	1
150	R:R:M181	R:R:Y183	10.78	Yes	Yes	1	4	4
151	R:R:Y183	R:R:Y184	17.87	Yes	No	1	4	4
152	R:R:Q203	R:R:Y184	15.78	No	No	0	3	4
153	R:R:L188	R:R:N185	6.87	No	No	0	7	4
154	R:R:R202	R:R:V186	5.23	Yes	No	0	3	5
155	R:R:Q203	R:R:V186	4.3	No	No	0	3	5
156	R:R:L187	R:R:P191	9.85	No	No	0	4	6
157	R:R:L187	R:R:R195	4.86	No	No	0	4	2
158	R:R:N190	R:R:R202	4.82	No	Yes	0	7	3
159	R:R:H273	R:R:N200	21.68	No	No	0	1	1
160	R:R:E269	R:R:Q203	6.37	No	No	0	5	3
161	R:R:K210	R:R:Y262	4.78	Yes	Yes	0	5	7
162	R:R:H263	R:R:K210	5.24	No	Yes	0	8	5
163	R:R:K210	R:R:S266	7.65	Yes	No	0	5	5
164	R:R:F211	R:R:L212	3.65	Yes	No	5	6	6
165	R:R:F211	R:R:F215	4.29	Yes	Yes	0	6	9
166	R:R:F211	R:R:L216	8.53	Yes	No	5	6	5
167	R:R:F211	R:R:L267	13.4	Yes	No	0	6	6
168	R:R:L212	R:R:L216	4.15	No	No	5	6	5
169	R:R:F215	R:R:L219	3.65	Yes	No	0	9	5
170	R:R:F215	R:R:G260	6.02	Yes	No	0	9	5
171	R:R:F215	R:R:H263	9.05	Yes	No	0	9	8
172	R:R:F255	R:R:L219	6.09	No	No	0	9	5
173	R:R:H226	R:R:I222	3.98	No	No	0	9	8
174	R:R:F255	R:R:I222	5.02	No	No	0	9	8
175	R:R:H226	R:R:V248	13.84	No	No	0	9	7
176	R:R:F244	R:R:V229	5.24	Yes	No	0	7	8
177	R:R:F244	R:R:S230	6.61	Yes	No	0	7	5
178	R:R:Q234	R:R:R240	11.68	No	Yes	0	5	5
179	R:R:F244	R:R:R240	9.62	Yes	Yes	6	7	5
180	R:R:F244	R:R:V248	5.24	Yes	No	0	7	7
181	R:R:L303	R:R:V251	5.96	Yes	No	0	8	8
182	R:R:V251	R:R:Y304	8.83	No	Yes	0	8	9
183	R:R:C258	R:R:N296	9.45	No	No	0	8	9
184	R:R:A293	R:R:W259	7.78	No	Yes	0	8	8
185	R:R:N296	R:R:W259	9.04	No	Yes	0	9	8
186	R:R:G260	R:R:P261	4.06	No	No	0	5	9
187	R:R:V289	R:R:Y262	3.79	No	Yes	0	7	7
188	R:R:T290	R:R:Y262	4.99	No	Yes	0	6	7
189	R:R:F265	R:R:L281	4.87	No	No	0	5	2
190	R:R:F265	R:R:G285	4.52	No	No	0	5	5
191	R:R:F265	R:R:V289	7.87	No	No	0	5	7
192	R:R:E269	R:R:V282	4.28	No	No	0	5	4
193	R:R:P276	R:R:R279	7.21	No	Yes	0	1	1
194	R:R:F288	R:R:L292	4.87	No	No	0	5	7
195	R:R:F294	R:R:T290	5.19	No	No	0	6	6
196	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
197	R:R:C308	R:R:M311	11.35	No	No	0	8	8
198	R:R:D310	R:R:M311	4.16	No	No	0	5	8
199	R:R:L312	R:R:R316	13.36	No	No	0	7	5
200	L:L:?1	R:R:L286	3.64	Yes	No	0	0	5
201	R:R:L278	R:R:R271	3.64	No	No	0	1	3
202	R:R:N275	R:R:R271	3.62	No	No	0	2	3
203	R:R:P165	R:R:V164	3.53	No	No	0	7	4
204	R:R:P218	R:R:V217	3.53	No	No	0	9	5
205	R:R:C130	R:R:S225	3.44	No	No	0	8	8
206	R:R:I53	R:R:P301	3.39	Yes	No	0	9	9
207	R:R:L286	R:R:P287	3.28	No	No	0	5	4
208	R:R:S126	R:R:S225	3.26	No	No	0	9	8
209	R:R:A74	R:R:I53	3.25	No	Yes	0	9	9
210	R:R:R313	R:R:R316	3.2	No	No	0	5	5
211	R:R:R316	R:R:R320	3.2	No	No	0	5	5
212	R:R:G94	R:R:H95	3.18	No	No	0	3	4
213	R:R:T163	R:R:V160	3.17	No	No	0	7	4
214	R:R:A250	R:R:L303	3.15	No	Yes	0	6	8
215	R:R:A253	R:R:L257	3.15	No	No	0	5	5
216	R:R:I110	R:R:S83	3.1	No	No	0	5	6
217	R:R:I53	R:R:V57	3.07	Yes	No	0	9	7
218	R:R:L176	R:R:S18	3	No	No	0	1	7
219	R:R:L47	R:R:S43	3	Yes	Yes	0	6	7
220	R:R:L47	R:R:S81	3	Yes	No	0	6	6
221	R:R:L73	R:R:S76	3	Yes	No	3	9	8
222	R:R:L121	R:R:S76	3	No	No	3	7	8
223	R:R:K105	R:R:T101	3	No	No	0	7	4
224	R:R:L106	R:R:S109	3	No	No	0	4	5
225	R:R:L213	R:R:S209	3	No	No	0	4	4
226	R:R:L91	R:R:V36	2.98	Yes	No	0	5	4
227	R:R:L44	R:R:V48	2.98	No	No	0	6	5
228	R:R:L45	R:R:V298	2.98	No	No	0	6	8
229	R:R:L315	R:R:V56	2.98	No	Yes	0	5	7
230	R:R:L212	R:R:V208	2.98	No	No	0	6	4
231	R:R:L233	R:R:V229	2.98	No	No	0	8	8
232	R:R:L247	R:R:V251	2.98	No	No	0	7	8
233	R:R:L268	R:R:V264	2.98	No	No	0	5	6
234	R:R:L306	R:R:V305	2.98	No	No	0	7	7
235	R:R:N200	R:R:V204	2.96	No	No	0	1	2
236	R:R:L247	R:R:T307	2.95	No	No	0	7	7
237	R:R:A92	R:R:H33	2.93	No	No	0	4	3
238	R:R:I110	R:R:N114	2.83	No	No	0	5	8
239	R:R:C59	R:R:F55	2.79	No	No	0	5	4
240	R:R:H33	R:R:V36	2.77	No	No	0	3	4
241	R:R:A35	R:R:F288	2.77	No	No	0	4	5
242	R:R:L47	R:R:L78	2.77	Yes	No	0	6	8
243	R:R:L54	R:R:L71	2.77	No	Yes	0	7	6
244	R:R:L75	R:R:L79	2.77	No	No	0	6	6
245	R:R:H149	R:R:V145	2.77	No	No	0	4	1
246	R:R:A272	R:R:R279	2.77	No	Yes	0	3	1
247	R:R:L158	R:R:N162	2.75	No	No	0	5	5
248	R:R:L189	R:R:N190	2.75	No	No	0	5	7
249	R:R:L231	R:R:Q234	2.66	No	No	0	4	5
250	R:R:R175	R:R:S18	2.64	No	No	0	1	7
251	R:R:N141	R:R:Q140	2.64	No	No	0	5	4
252	R:R:F55	R:R:V56	2.62	No	Yes	0	4	7
253	R:R:R232	R:R:V133	2.62	No	No	0	5	8
254	R:R:R202	R:R:T198	2.59	Yes	No	0	3	3
255	R:R:R243	R:R:T307	2.59	No	No	0	7	7
256	R:R:H235	R:R:L231	2.57	No	No	0	4	4
257	R:R:H142	R:R:N141	2.55	No	No	0	4	5
258	R:R:F116	R:R:L213	2.44	Yes	No	0	7	4
259	R:R:D310	R:R:R313	2.38	No	No	0	5	5
260	R:R:G242	R:R:P241	2.03	No	No	0	5	6
261	R:R:G277	R:R:P280	2.03	No	No	0	1	2
262	R:R:C11	R:R:P12	1.88	No	No	0	7	6
263	R:R:C308	R:R:P309	1.88	No	No	0	8	5
264	R:R:G40	R:R:S43	1.86	No	Yes	0	4	7
265	R:R:G46	R:R:V298	1.84	No	No	0	8	8
266	R:R:G242	R:R:V245	1.84	No	No	0	5	5
267	R:R:G100	R:R:T102	1.82	No	No	0	8	3
268	R:R:A228	R:R:C130	1.81	No	No	0	3	8
269	R:R:A207	R:R:A270	1.79	No	No	0	5	5
270	R:R:G100	R:R:L99	1.71	No	No	0	8	7
271	R:R:C130	R:R:V134	1.71	No	No	0	8	8
272	R:R:A207	R:R:S266	1.71	No	No	0	5	5
273	R:R:A42	R:R:V298	1.7	No	No	0	7	8
274	R:R:A146	R:R:T144	1.68	No	No	0	4	6
275	R:R:A147	R:R:T144	1.68	No	No	0	3	6
276	R:R:L206	R:R:P165	1.64	No	No	0	5	7
277	R:R:L292	R:R:P261	1.64	No	No	0	7	9
278	R:R:N190	R:R:P191	1.63	No	No	0	7	6
279	R:R:S224	R:R:S225	1.63	No	No	0	4	8
280	R:R:N275	R:R:P276	1.63	No	No	0	2	1
281	R:R:V48	R:R:V52	1.6	No	No	0	5	6
282	R:R:V52	R:R:V56	1.6	No	Yes	0	6	7
283	R:R:V66	R:R:V70	1.6	No	No	0	7	8
284	R:R:V248	R:R:V252	1.6	No	No	0	7	8
285	R:R:S318	R:R:T321	1.6	No	No	0	4	3
286	R:R:T321	R:R:V322	1.59	No	No	0	3	4
287	R:R:A82	R:R:L47	1.58	No	Yes	0	5	6
288	R:R:A159	R:R:L113	1.58	No	No	0	8	5
289	R:R:A139	R:R:L131	1.58	No	No	0	5	6
290	R:R:A157	R:R:L158	1.58	No	No	0	4	5
291	R:R:A256	R:R:L219	1.58	No	No	0	5	5
292	R:R:A254	R:R:L303	1.58	No	Yes	0	7	8
293	R:R:A274	R:R:N275	1.56	No	No	0	1	2
294	R:R:G285	R:R:R284	1.5	No	No	0	5	1
295	R:R:L268	R:R:V282	1.49	No	No	0	5	4
296	R:R:L303	R:R:V302	1.49	Yes	No	0	8	6
297	R:R:D171	R:R:T101	1.45	No	No	0	5	4
298	R:R:D171	R:R:T172	1.45	No	No	0	5	6
299	R:R:P136	R:R:R135	1.44	No	No	0	8	6
300	R:R:P241	R:R:R240	1.44	No	Yes	6	6	5
301	R:R:F244	R:R:P241	1.44	Yes	No	6	7	6
302	R:R:P280	R:R:R279	1.44	No	Yes	0	2	1
303	R:R:I110	R:R:L113	1.43	No	No	0	5	5
304	R:R:L233	R:R:R238	1.21	No	No	0	8	3
305	R:R:R317	R:R:R60	1.07	No	No	0	4	5
306	R:R:R239	R:R:R240	1.07	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.0082	11	1	0
2	R:R:S43	4.8025	4	0	7
3	R:R:L47	2.5875	4	0	6
4	R:R:I53	4.7325	4	0	9
5	R:R:V56	3.0125	4	0	7
6	R:R:W69	5.77667	6	2	7
7	R:R:L71	4.835	4	0	6
8	R:R:L73	4.865	4	3	9
9	R:R:D77	6.865	4	3	9
10	R:R:L91	6.63	4	0	5
11	R:R:W97	10.46	5	1	9
12	R:R:F103	8.7875	4	1	6
13	R:R:H107	7.2425	4	1	5
14	R:R:F111	9.025	4	1	6
15	R:R:F112	6.79	4	1	5
16	R:R:M115	6.965	4	4	8
17	R:R:F116	5.348	5	4	7
18	R:R:D128	6.0375	4	2	8
19	R:R:R170	7.684	5	1	5
20	R:R:R179	10.94	4	0	1
21	R:R:M181	10.1425	4	1	4
22	R:R:Y183	10.415	4	1	4
23	R:R:R202	4.7625	4	0	3
24	R:R:K210	5.72	5	0	5
25	R:R:F211	7.4675	4	5	6
26	R:R:F215	5.7525	4	0	9
27	R:R:R240	5.9525	4	6	5
28	R:R:F244	5.63	5	6	7
29	R:R:W259	8.3325	4	0	8
30	R:R:Y262	5.4525	4	0	7
31	R:R:R279	5.372	5	0	1
32	R:R:N300	7.8375	4	3	9
33	R:R:L303	3.045	4	0	8
34	R:R:Y304	7.57	4	2	9
35	W:W:?1	9.77455	11	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M181	14.2065	20.46	Yes	Yes	1	0	4
2	L:L:?1	R:R:Y184	19.6076	17.73	Yes	No	1	0	4
3	R:R:Q203	R:R:Y184	20.0884	15.78	No	No	0	3	4
4	R:R:E269	R:R:Q203	15.9507	6.37	No	No	0	5	3
5	R:R:E269	R:R:I13	12.2201	4.1	No	No	0	5	7
6	L:L:?1	R:R:Y183	10.7567	4.63	Yes	Yes	1	0	4
7	R:R:M17	R:R:Y183	10.876	8.38	No	Yes	0	7	4
8	L:L:?1	R:R:F90	12.5781	25.63	Yes	No	0	0	5
9	L:L:?1	R:R:F111	10.132	6.41	Yes	Yes	1	0	6
10	R:R:F111	R:R:F294	28.7675	11.79	Yes	No	0	6	6
11	R:R:F294	R:R:L84	36.8077	19.49	No	No	0	6	8
12	R:R:L84	R:R:S43	28.3288	9.01	No	Yes	0	8	7
13	R:R:L47	R:R:S43	21.8958	3	Yes	Yes	0	6	7
14	R:R:L47	R:R:S81	15.3997	3	Yes	No	0	6	6
15	R:R:G46	R:R:S81	13.2203	3.71	No	No	0	8	6
16	R:R:G46	R:R:V298	11.0339	1.84	No	No	0	8	8
17	L:L:?1	R:R:F112	50.537	7.21	Yes	Yes	1	0	5
18	R:R:F112	R:R:K210	71.8256	4.96	Yes	Yes	0	5	5
19	R:R:H263	R:R:K210	100	5.24	No	Yes	0	8	5
20	R:R:H263	R:R:M115	87.8185	5.25	No	Yes	0	8	8
21	R:R:M115	R:R:W259	55.2537	12.8	Yes	Yes	0	8	8
22	R:R:N296	R:R:W259	50.8949	9.04	No	Yes	0	9	8
23	R:R:N296	R:R:N300	49.6385	12.26	No	Yes	0	9	9
24	R:R:D77	R:R:N300	41.8228	6.73	Yes	Yes	3	9	9
25	R:R:D77	R:R:N50	40.391	10.77	Yes	No	0	9	9
26	R:R:A74	R:R:N50	39.4539	4.69	No	No	0	9	9
27	R:R:A74	R:R:I53	38.4993	3.25	No	Yes	0	9	9
28	R:R:I53	R:R:V57	23.5523	3.07	Yes	No	0	9	7
29	R:R:M61	R:R:V57	16.0104	4.56	No	No	0	6	7
30	R:R:K314	R:R:M61	14.9014	11.52	No	No	0	4	6
31	R:R:K314	R:R:R60	13.8836	3.71	No	No	0	4	5
32	R:R:R60	R:R:S318	11.6375	10.54	No	No	0	5	4
33	R:R:F116	R:R:M115	36.9025	4.98	Yes	Yes	4	7	8
34	R:R:F116	R:R:F120	30.8626	4.29	Yes	No	0	7	6
35	R:R:F120	R:R:L155	29.9853	4.87	No	No	0	6	7
36	R:R:L155	W:W:?1	29.2097	7.01	No	Yes	0	7	0
37	R:R:W69	W:W:?1	15.0944	6.59	Yes	Yes	2	7	0
38	R:R:L122	R:R:N300	17.9055	4.12	No	Yes	0	9	9
39	R:R:L122	R:R:Y304	17.0211	8.21	No	Yes	0	9	9
40	R:R:I53	R:R:V305	13.8275	9.22	Yes	No	0	9	7
41	R:R:V305	R:R:V70	11.6481	8.02	No	No	0	7	8
42	L:L:?1	R:R:H107	15.0418	10.15	Yes	Yes	1	0	5
43	R:R:H107	R:R:S83	10.2443	9.76	Yes	No	0	5	6
44	R:R:F111	R:R:Y262	13.838	8.25	Yes	Yes	0	6	7
45	R:R:F215	R:R:H263	42.8792	9.05	Yes	No	0	9	8
46	R:R:F215	R:R:L219	32.456	3.65	Yes	No	0	9	5
47	R:R:F255	R:R:L219	30.4696	6.09	No	No	0	9	5
48	R:R:F255	R:R:I222	29.4518	5.02	No	No	0	9	8
49	R:R:H226	R:R:I222	20.0884	3.98	No	No	0	9	8
50	R:R:H226	R:R:V248	19.0777	13.84	No	No	0	9	7
51	R:R:F244	R:R:V248	16.979	5.24	Yes	No	0	7	7
52	R:R:K210	R:R:Y166	10.7356	5.97	Yes	No	0	5	4
53	R:R:T290	R:R:Y262	11.5393	4.99	No	Yes	0	6	7
54	R:R:F294	R:R:T290	10.9532	5.19	No	No	0	6	6
55	R:R:F111	R:R:F112	11.7955	9.65	Yes	Yes	1	6	5
56	R:R:F112	R:R:R170	11.4129	5.34	Yes	Yes	1	5	5
57	R:R:K210	R:R:Y262	25.0579	4.78	Yes	Yes	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F87	12.02	1	Yes	No	0	6	0	1
L:L:?1	R:R:F90	25.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:H107	10.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F111	6.41	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F112	7.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R170	7.99	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M181	20.46	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:C182	5.22	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y183	4.63	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y184	17.73	1	Yes	No	0	4	0	1
R:R:M17	R:R:Y183	8.38	0	No	Yes	7	4	2	1
R:R:H107	R:R:S83	9.76	1	Yes	No	5	6	1	2
R:R:F103	R:R:F86	16.08	1	Yes	No	6	7	2	2
R:R:F86	R:R:H107	4.53	1	No	Yes	7	5	2	1
R:R:F87	R:R:L91	12.18	0	No	Yes	6	5	1	2
R:R:F90	R:R:L91	3.65	0	No	Yes	5	5	1	2
R:R:F90	R:R:W97	9.02	0	No	Yes	5	9	1	2
R:R:F103	R:R:W97	6.01	1	Yes	Yes	6	9	2	2
R:R:C104	R:R:W97	3.92	0	No	Yes	9	9	2	2
R:R:F103	R:R:H107	4.53	1	Yes	Yes	6	5	2	1
R:R:C104	R:R:R170	5.57	0	No	Yes	9	5	2	1
R:R:C104	R:R:C182	7.28	0	No	No	9	9	2	1
R:R:K105	R:R:R170	3.71	0	No	Yes	7	5	2	1
R:R:R170	R:R:S108	15.81	1	Yes	No	5	5	1	2
R:R:F111	R:R:F112	9.65	1	Yes	Yes	6	5	1	1
R:R:F111	R:R:Y262	8.25	1	Yes	Yes	6	7	1	2
R:R:F111	R:R:F294	11.79	1	Yes	No	6	6	1	2
R:R:F112	R:R:R170	5.34	1	Yes	Yes	5	5	1	1
R:R:F112	R:R:K210	4.96	1	Yes	Yes	5	5	1	2
R:R:I173	R:R:M181	4.37	1	No	Yes	3	4	2	1
R:R:M181	R:R:R179	4.96	1	Yes	Yes	4	1	1	2
R:R:M181	R:R:Y183	10.78	1	Yes	Yes	4	4	1	1
R:R:Y183	R:R:Y184	17.87	1	Yes	No	4	4	1	1
R:R:Q203	R:R:Y184	15.78	0	No	No	3	4	2	1
R:R:K210	R:R:Y262	4.78	0	Yes	Yes	5	7	2	2
L:L:?1	R:R:L286	3.64	1	Yes	No	0	5	0	1
R:R:L286	R:R:P287	3.28	0	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V65	R:R:W69	4.9	0	No	Yes	5	7	2	1
R:R:R143	R:R:V65	10.46	2	No	No	7	5	2	2
R:R:A124	R:R:W69	5.19	0	No	Yes	7	7	2	1
R:R:I125	R:R:W69	5.87	2	No	Yes	8	7	2	1
R:R:D128	R:R:W69	5.58	2	Yes	Yes	8	7	1	1
R:R:C152	R:R:W69	6.53	0	No	Yes	7	7	2	1
R:R:W69	W:W:?1	6.59	2	Yes	Yes	7	0	1	0
R:R:F120	R:R:L155	4.87	0	No	No	6	7	2	1
R:R:I221	R:R:S123	4.64	0	No	No	7	7	2	1
R:R:S123	W:W:?1	5.43	0	No	Yes	7	0	1	0
R:R:I221	R:R:L127	4.28	0	No	No	7	6	2	1
R:R:L127	W:W:?1	8.01	0	No	Yes	6	0	1	0
R:R:D128	R:R:Q132	3.92	2	Yes	No	8	7	1	2
R:R:D128	R:R:R143	10.72	2	Yes	No	8	7	1	2
R:R:D128	W:W:?1	3.93	2	Yes	Yes	8	0	1	0
R:R:L131	R:R:W138	4.56	0	No	No	6	4	2	1
R:R:Q132	R:R:R143	11.68	2	No	No	7	7	2	2
R:R:H142	R:R:W138	20.1	2	No	No	4	4	1	1
R:R:W138	W:W:?1	10.71	2	No	Yes	4	0	1	0
R:R:H142	W:W:?1	26.05	2	No	Yes	4	0	1	0
R:R:A147	W:W:?1	6.84	0	No	Yes	3	0	1	0
R:R:K150	W:W:?1	8.16	0	No	Yes	2	0	1	0
R:R:V151	W:W:?1	18.32	0	No	Yes	5	0	1	0
R:R:V154	W:W:?1	6.47	0	No	Yes	3	0	1	0
R:R:L155	W:W:?1	7.01	0	No	Yes	7	0	1	0
R:R:H142	R:R:N141	2.55	2	No	No	4	5	1	2
R:R:A147	R:R:T144	1.68	0	No	No	3	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IYB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	281
Number of Links	306
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	50783
Length Of Smallest Path	3
Average Path Length	13.4163
Length of Longest Path	30
Minimum Path Strength	1.255
Average Path Strength	7.16828
Maximum Path Strength	23.045
Minimum Path Correlation	0.7
Average Path Correlation	0.933006
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	56.2532
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.2748
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PG2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PG2
Name	Prostaglandin D2
Synonyms	(5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	448457
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


Code	A1D
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5Y4
Sequence	>9IYB_nogp_Chain_R L C P I L E Q M S R L Q S I D H A A V L L H G L A S L L G L V E N G V I L F V V G C R M R Q T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G H S W E L G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R P V W A Q N H R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D T I S R L D G R I M C Y Y N V L L L N P R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R G R R R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A H A N P G L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D M L R K L R R S L R T V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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