psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q9	R:R:S6	8.66	No	No	0	4	6
2	R:R:F8	R:R:I268	8.79	No	No	0	4	1
3	R:R:N70	R:R:Q9	5.28	No	No	1	3	4
4	R:R:Q9	R:R:Y271	5.64	No	Yes	1	4	3
5	R:R:E16	R:R:Y12	15.71	Yes	Yes	1	6	5
6	R:R:N70	R:R:Y12	10.47	No	Yes	1	3	5
7	R:R:Y12	R:R:Y271	8.94	Yes	Yes	1	5	3
8	R:R:I274	R:R:Y12	6.04	Yes	Yes	1	5	5
9	R:R:I13	R:R:I67	8.83	No	Yes	1	5	6
10	R:R:I13	R:R:I71	2.94	No	No	1	5	4
11	R:R:I15	R:R:I19	2.94	No	No	1	5	7
12	R:R:F275	R:R:I15	11.3	Yes	No	1	5	5
13	R:R:E16	R:R:I63	8.2	Yes	Yes	1	6	6
14	R:R:E16	R:R:I67	2.73	Yes	Yes	1	6	6
15	R:R:E16	R:R:H278	14.77	Yes	Yes	1	6	7
16	R:R:F275	R:R:I19	3.77	Yes	No	1	5	7
17	R:R:G279	R:R:I19	3.53	No	No	0	5	7
18	R:R:A20	R:R:I63	4.87	No	Yes	0	5	6
19	R:R:N27	R:R:S23	4.47	Yes	Yes	2	9	8
20	R:R:D55	R:R:S23	2.94	Yes	Yes	2	9	8
21	R:R:S23	R:R:S281	4.89	Yes	No	2	8	9
22	R:R:P25	R:R:V24	3.53	No	No	0	4	6
23	R:R:D55	R:R:N27	16.16	Yes	Yes	2	9	9
24	R:R:N27	R:R:V56	5.91	Yes	No	0	9	7
25	R:R:N27	R:R:P285	6.52	Yes	No	2	9	9
26	R:R:F299	R:R:L29	7.31	No	No	0	7	7
27	R:R:A52	R:R:V30	3.39	No	Yes	0	9	9
28	R:R:A289	R:R:V30	3.39	No	Yes	2	7	9
29	R:R:F295	R:R:V30	9.18	Yes	Yes	2	9	9
30	R:R:A52	R:R:I31	3.25	No	No	0	9	7
31	R:R:V36	R:R:W32	7.36	No	No	0	5	4
32	R:R:A33	R:R:F295	4.16	No	Yes	0	8	9
33	R:R:V34	R:R:V49	4.81	No	No	0	8	5
34	R:R:K35	R:R:V36	3.04	No	No	0	3	5
35	R:R:A39	R:R:N37	4.69	No	No	0	6	6
36	R:R:L40	R:R:N37	10.98	Yes	No	4	8	6
37	R:R:N37	R:R:T298	10.24	No	No	4	6	6
38	R:R:Q38	R:R:R41	11.68	No	No	0	6	7
39	R:R:F45	R:R:L40	9.74	No	Yes	4	8	8
40	R:R:K294	R:R:L40	4.23	No	Yes	4	6	8
41	R:R:L40	R:R:T298	5.9	Yes	No	4	8	6
42	R:R:D42	R:R:R108	7.15	No	Yes	0	7	8
43	R:R:D42	R:R:K116	4.15	No	No	0	7	4
44	R:R:D104	R:R:T44	10.12	Yes	No	6	9	8
45	R:R:R108	R:R:T44	9.06	Yes	No	6	8	8
46	R:R:F45	R:R:I292	5.02	No	No	4	8	8
47	R:R:F45	R:R:K294	6.2	No	No	4	8	6
48	R:R:A100	R:R:F47	2.77	No	Yes	0	7	8
49	R:R:D104	R:R:F47	7.17	Yes	Yes	0	9	8
50	R:R:A124	R:R:F47	2.77	No	Yes	0	7	8
51	R:R:F47	R:R:I128	3.77	Yes	No	0	8	8
52	R:R:I128	R:R:S50	12.39	No	No	0	8	9
53	R:R:S50	R:R:W132	4.94	No	No	0	9	9
54	R:R:D55	R:R:L51	2.71	Yes	Yes	2	9	9
55	R:R:A97	R:R:L51	4.73	No	Yes	0	8	9
56	R:R:L51	R:R:L98	2.77	Yes	Yes	2	9	8
57	R:R:I101	R:R:L51	2.85	No	Yes	2	9	9
58	R:R:L51	R:R:N284	5.49	Yes	Yes	2	9	9
59	R:R:A54	R:R:S93	3.42	No	No	8	8	7
60	R:R:A54	R:R:W132	2.59	No	No	8	8	9
61	R:R:D55	R:R:S281	8.83	Yes	No	2	9	9
62	R:R:D55	R:R:N284	4.04	Yes	Yes	2	9	9
63	R:R:D55	R:R:P285	3.22	Yes	No	2	9	9
64	R:R:A57	R:R:L90	4.73	No	No	0	6	7
65	R:R:G59	R:R:V58	3.68	No	No	0	7	8
66	R:R:V58	R:R:V62	6.41	No	Yes	0	8	6
67	R:R:S281	R:R:V58	6.46	No	No	0	9	8
68	R:R:L61	R:R:L90	2.77	No	No	0	5	7
69	R:R:V62	R:R:V87	4.81	Yes	No	0	6	6
70	R:R:L90	R:R:V62	4.47	No	Yes	0	7	6
71	R:R:H278	R:R:V62	4.15	Yes	Yes	0	7	6
72	R:R:I63	R:R:P64	3.39	Yes	No	0	6	8
73	R:R:H278	R:R:I63	3.98	Yes	Yes	1	7	6
74	R:R:L65	R:R:P86	3.28	No	No	0	5	4
75	R:R:A66	R:R:H278	2.93	No	Yes	0	7	7
76	R:R:I67	R:R:I71	2.94	Yes	No	1	6	4
77	R:R:L68	R:R:P73	3.28	No	No	0	4	3
78	R:R:N70	R:R:Y271	10.47	No	Yes	1	3	3
79	R:R:G72	R:R:P73	4.06	No	No	0	3	3
80	R:R:T75	R:R:T79	4.71	No	No	0	7	5
81	R:R:C169	R:R:T75	3.38	No	No	0	9	7
82	R:R:T79	R:R:Y76	2.5	No	No	0	5	6
83	R:R:E164	R:R:Y76	8.98	No	No	0	3	6
84	R:R:V166	R:R:Y76	3.79	No	No	0	3	6
85	R:R:F77	R:R:N147	6.04	Yes	No	5	3	6
86	R:R:F77	R:R:L149	9.74	Yes	No	5	3	4
87	R:R:F77	R:R:V152	2.62	Yes	No	5	3	1
88	R:R:F77	R:R:I167	5.02	Yes	No	5	3	4
89	R:R:F77	R:R:V174	6.55	Yes	No	0	3	3
90	R:R:C169	R:R:C80	7.28	No	No	0	9	9
91	R:R:C80	R:R:V174	6.83	No	No	0	9	3
92	R:R:L81	R:R:M143	2.83	No	Yes	0	5	5
93	R:R:L81	R:R:N147	5.49	No	No	0	5	6
94	R:R:A84	R:R:F171	2.77	No	No	0	4	4
95	R:R:C85	R:R:I89	3.27	Yes	Yes	7	6	5
96	R:R:C85	R:R:L140	3.17	Yes	Yes	7	6	4
97	R:R:C85	R:R:M143	6.48	Yes	Yes	7	6	5
98	L:L:?1	R:R:V87	6.88	Yes	No	0	0	6
99	R:R:L88	R:R:Y179	3.52	No	Yes	0	4	6
100	R:R:F136	R:R:I89	5.02	No	Yes	0	3	5
101	R:R:G139	R:R:I89	3.53	No	Yes	0	6	5
102	R:R:I89	R:R:L140	2.85	Yes	Yes	7	5	4
103	R:R:T91	R:R:W247	3.64	No	Yes	0	6	8
104	L:L:?1	R:R:T91	8.76	Yes	No	0	0	6
105	R:R:L96	R:R:Q92	7.99	No	Yes	0	4	6
106	R:R:Q92	R:R:S135	5.78	Yes	No	0	6	8
107	R:R:Q92	R:R:V138	5.73	Yes	No	3	6	5
108	R:R:N184	R:R:Q92	2.64	No	Yes	0	5	6
109	R:R:Q92	R:R:W188	4.38	Yes	Yes	3	6	8
110	R:R:S93	R:R:W132	16.06	No	No	8	7	9
111	R:R:S135	R:R:S93	4.89	No	No	0	8	7
112	R:R:I95	R:R:V189	3.07	Yes	Yes	1	8	5
113	R:R:I95	R:R:P192	3.39	Yes	No	0	8	8
114	R:R:F243	R:R:I95	5.02	Yes	Yes	1	9	8
115	R:R:I95	R:R:W247	15.27	Yes	Yes	1	8	8
116	R:R:C131	R:R:L96	3.17	No	No	0	7	4
117	R:R:L134	R:R:L96	2.77	No	No	0	4	4
118	R:R:L98	R:R:N284	4.12	Yes	Yes	2	8	9
119	R:R:L98	R:R:Y288	4.69	Yes	Yes	2	8	9
120	R:R:L99	R:R:V103	2.98	No	No	0	7	6
121	R:R:L195	R:R:L99	5.54	No	No	0	6	7
122	R:R:I101	R:R:R105	2.51	No	No	2	9	9
123	R:R:I101	R:R:Y288	3.63	No	Yes	2	9	9
124	R:R:A102	R:R:Y200	4	No	Yes	0	9	9
125	R:R:D104	R:R:R108	5.96	Yes	Yes	6	9	8
126	R:R:D104	R:R:Y115	5.75	Yes	No	6	9	7
127	R:R:R105	R:R:Y200	7.2	No	Yes	0	9	9
128	R:R:R105	R:R:Y288	3.09	No	Yes	2	9	9
129	R:R:L107	R:R:Y106	3.52	No	Yes	0	5	7
130	R:R:K110	R:R:Y106	20.3	No	Yes	0	7	7
131	R:R:E202	R:R:Y106	5.61	No	Yes	0	4	7
132	R:R:V203	R:R:Y106	3.79	No	Yes	0	9	7
133	R:R:R108	R:R:Y115	25.72	Yes	No	6	8	7
134	R:R:L206	R:R:V109	2.98	No	No	0	5	9
135	R:R:I111	R:R:R114	3.76	No	No	0	6	5
136	R:R:I111	R:R:V118	4.61	No	No	0	6	4
137	R:R:M117	R:R:R114	2.48	No	No	0	5	5
138	R:R:V119	R:R:Y115	13.88	No	No	0	7	7
139	R:R:V118	R:R:V119	3.21	No	No	0	4	7
140	R:R:P121	R:R:T120	5.25	No	No	0	3	8
141	R:R:R123	R:R:T120	5.17	No	No	0	5	8
142	R:R:G130	R:R:I133	3.53	No	No	0	1	4
143	R:R:L134	R:R:W188	13.67	No	Yes	0	4	8
144	R:R:F183	R:R:V138	2.62	Yes	No	3	5	5
145	R:R:V138	R:R:W188	7.36	No	Yes	3	5	8
146	R:R:L140	R:R:M143	2.83	Yes	Yes	7	4	5
147	R:R:P142	R:R:T141	3.5	No	No	3	4	6
148	R:R:T141	R:R:Y179	4.99	No	Yes	3	6	6
149	R:R:F183	R:R:T141	2.59	Yes	No	3	5	6
150	R:R:I175	R:R:P142	5.08	No	No	3	3	4
151	R:R:P142	R:R:Y179	12.52	No	Yes	3	4	6
152	R:R:S176	R:R:W146	3.71	Yes	Yes	3	5	6
153	R:R:E178	R:R:W146	11.99	No	Yes	3	3	6
154	R:R:W146	R:R:Y179	12.54	Yes	Yes	3	6	6
155	R:R:F183	R:R:W146	3.01	Yes	Yes	3	5	6
156	R:R:L149	R:R:N147	4.12	No	No	5	4	6
157	R:R:N148	R:R:S176	4.47	No	Yes	0	4	5
158	R:R:P165	R:R:V152	3.53	No	No	0	5	1
159	R:R:I167	R:R:V152	3.07	No	No	5	4	1
160	R:R:S161	R:R:W156	8.65	No	No	0	6	1
161	R:R:P165	R:R:W156	8.11	No	No	0	5	1
162	R:R:I167	R:R:K173	10.18	No	No	0	4	3
163	R:R:E170	R:R:E172	6.34	No	No	0	4	4
164	R:R:F171	R:R:I175	3.77	No	No	0	4	3
165	L:L:?1	R:R:F171	24.12	Yes	No	0	0	4
166	R:R:E172	R:R:M177	2.71	No	No	0	4	3
167	L:L:?1	R:R:E172	10.5	Yes	No	0	0	4
168	R:R:I175	R:R:Y179	3.63	No	Yes	3	3	6
169	R:R:E178	R:R:S176	5.75	No	Yes	3	3	5
170	R:R:S176	R:R:Y179	2.54	Yes	Yes	3	5	6
171	R:R:M177	R:R:N254	2.8	No	No	0	3	5
172	R:R:L258	R:R:M177	2.83	No	No	0	4	3
173	R:R:F183	R:R:Y179	8.25	Yes	Yes	3	5	6
174	R:R:M180	R:R:N184	5.61	No	No	0	5	5
175	L:L:?1	R:R:M180	5.6	Yes	No	0	0	5
176	R:R:F186	R:R:V181	2.62	No	No	0	4	4
177	R:R:C255	R:R:V181	3.42	No	No	0	5	4
178	R:R:L258	R:R:V181	5.96	No	No	0	4	4
179	R:R:L258	R:R:Y182	5.86	No	No	0	4	4
180	R:R:F183	R:R:W188	6.01	Yes	Yes	3	5	8
181	R:R:N184	R:R:V189	2.96	No	Yes	0	5	5
182	R:R:F185	R:R:V189	2.62	No	Yes	1	5	5
183	R:R:F185	R:R:H251	10.18	No	No	1	5	7
184	R:R:V187	R:R:W188	11.03	No	Yes	0	5	8
185	R:R:H251	R:R:V189	4.15	No	Yes	1	7	5
186	R:R:L190	R:R:P191	3.28	No	No	0	5	4
187	R:R:L190	R:R:L194	5.54	No	No	0	5	3
188	R:R:P191	R:R:P192	5.84	No	No	0	4	8
189	R:R:F243	R:R:L193	7.31	Yes	No	0	9	6
190	R:R:A244	R:R:L193	3.15	No	No	0	6	6
191	R:R:L193	R:R:L248	4.15	No	No	0	6	7
192	R:R:I199	R:R:L195	2.85	No	No	0	6	6
193	R:R:L240	R:R:M196	2.83	No	No	0	8	8
194	R:R:F243	R:R:M196	7.46	Yes	No	0	9	8
195	R:R:L240	R:R:V197	4.47	No	No	0	8	5
196	R:R:L236	R:R:Y200	8.21	No	Yes	0	8	9
197	R:R:I239	R:R:Y200	8.46	No	Yes	0	8	9
198	R:R:L240	R:R:Y200	5.86	No	Yes	0	8	9
199	R:R:E202	R:R:L206	3.98	No	No	0	4	5
200	R:R:I207	R:R:V203	3.07	No	No	0	8	9
201	R:R:E229	R:R:F204	8.16	No	Yes	0	6	6
202	R:R:A233	R:R:F204	4.16	No	Yes	0	7	6
203	R:R:I207	R:R:L211	2.85	No	No	0	8	4
204	R:R:I207	R:R:I232	4.42	No	No	0	8	7
205	R:R:N212	R:R:R208	3.62	No	No	0	5	5
206	R:R:E229	R:R:R208	8.14	No	No	0	6	5
207	R:R:K213	R:R:Q210	8.14	No	No	0	3	7
208	R:R:I232	R:R:K228	2.91	No	No	0	7	6
209	R:R:R291	R:R:S235	2.64	No	No	0	7	8
210	R:R:F241	R:R:L245	9.74	No	No	0	5	6
211	R:R:L242	R:R:S246	3	No	No	0	6	8
212	R:R:L242	R:R:M283	5.65	No	No	0	6	6
213	R:R:L242	R:R:V287	2.98	No	No	0	6	8
214	R:R:F243	R:R:W247	10.02	Yes	Yes	1	9	8
215	R:R:N280	R:R:S246	8.94	No	No	0	9	8
216	R:R:T277	R:R:W247	3.64	No	Yes	1	7	8
217	R:R:N280	R:R:W247	10.17	No	Yes	0	9	8
218	R:R:L250	R:R:N254	2.75	Yes	No	1	6	5
219	R:R:A273	R:R:L250	4.73	No	Yes	0	5	6
220	R:R:I274	R:R:L250	2.85	Yes	Yes	1	5	6
221	R:R:L250	R:R:T277	7.37	Yes	No	1	6	7
222	L:L:?1	R:R:L250	12.79	Yes	Yes	1	0	6
223	R:R:I256	R:R:L253	2.85	No	No	0	4	4
224	R:R:L253	R:R:L269	5.54	No	No	0	4	4
225	L:L:?1	R:R:N254	9.97	Yes	No	1	0	5
226	R:R:C255	R:R:F259	5.59	No	No	0	5	4
227	R:R:K265	R:R:T257	7.51	No	No	0	3	4
228	R:R:C260	R:R:C263	7.28	No	No	0	4	2
229	R:R:K265	R:R:T270	3	No	No	0	3	4
230	R:R:S267	R:R:Y271	2.54	No	Yes	0	3	3
231	R:R:I268	R:R:I272	2.94	No	No	0	1	3
232	R:R:I274	R:R:T270	3.04	Yes	No	0	5	4
233	R:R:F275	R:R:I272	7.54	Yes	No	0	5	3
234	R:R:I272	R:R:L276	2.85	No	No	0	3	7
235	R:R:H278	R:R:I274	3.98	Yes	Yes	1	7	5
236	L:L:?1	R:R:I274	2.83	Yes	Yes	1	0	5
237	L:L:?1	R:R:T277	3.89	Yes	No	1	0	7
238	L:L:?1	R:R:H278	4.24	Yes	Yes	1	0	7
239	R:R:N280	R:R:N284	10.9	No	Yes	0	9	9
240	R:R:V287	R:R:Y288	3.79	No	Yes	0	8	9
241	R:R:A289	R:R:F295	8.32	No	Yes	2	7	9
242	R:R:F290	R:R:R296	8.55	No	No	0	6	8
243	R:R:I292	R:R:K294	2.91	No	No	4	8	6
244	R:R:Q293	R:R:R296	10.51	No	No	0	4	8
245	R:R:Q293	R:R:V297	2.87	No	No	0	4	4
246	R:R:F295	R:R:L29	2.44	Yes	No	0	9	7
247	R:R:F299	R:R:L300	2.44	No	No	0	7	5
248	R:R:I199	R:R:Y106	2.42	No	Yes	0	6	7
249	R:R:I199	R:R:Y200	2.42	No	Yes	0	6	9
250	R:R:L211	R:R:Y225	2.34	No	No	0	4	3
251	R:R:E16	R:R:F275	2.33	Yes	Yes	1	6	5
252	R:R:F204	R:R:Y205	2.06	Yes	No	0	6	4
253	R:R:R208	R:R:Y205	2.06	No	No	0	5	4
254	R:R:G26	R:R:P25	2.03	No	No	0	8	4
255	R:R:C85	R:R:P86	1.88	Yes	No	0	6	4
256	R:R:C260	R:R:P261	1.88	No	No	0	4	4
257	R:R:A273	R:R:P249	1.87	No	No	0	5	9
258	R:R:G59	R:R:V24	1.84	No	No	0	7	6
259	R:R:A124	R:R:A43	1.79	No	No	0	7	6
260	R:R:P285	R:R:V30	1.77	No	Yes	2	9	9
261	R:R:G72	R:R:I71	1.76	No	No	0	3	4
262	R:R:G163	R:R:M162	1.75	No	No	0	4	4
263	R:R:A282	R:R:S23	1.71	No	Yes	0	6	8
264	R:R:G139	R:R:L88	1.71	No	No	0	6	4
265	R:R:G227	R:R:L230	1.71	No	No	0	3	5
266	R:R:A282	R:R:V22	1.7	No	No	0	6	4
267	R:R:I111	R:R:P112	1.69	No	No	0	6	8
268	R:R:I268	R:R:P266	1.69	No	No	0	1	4
269	R:R:A33	R:R:T298	1.68	No	No	0	8	6
270	R:R:C46	R:R:I128	1.64	No	No	0	4	8
271	R:R:C169	R:R:I69	1.64	No	No	0	9	3
272	R:R:C260	R:R:I256	1.64	No	No	0	4	4
273	R:R:L269	R:R:P266	1.64	No	No	0	4	4
274	R:R:A289	R:R:I48	1.62	No	No	0	7	8
275	R:R:V24	R:R:V28	1.6	No	No	0	6	5
276	R:R:V28	R:R:V56	1.6	No	No	0	5	7
277	R:R:V49	R:R:V53	1.6	No	No	0	5	6
278	R:R:A151	R:R:N148	1.56	No	No	0	3	4
279	R:R:I5	R:R:S6	1.55	No	No	0	4	6
280	R:R:I239	R:R:S235	1.55	No	No	0	8	8
281	R:R:I13	R:R:V17	1.54	No	No	1	5	4
282	R:R:I67	R:R:V17	1.54	Yes	No	1	6	4
283	R:R:I31	R:R:V53	1.54	No	No	0	7	6
284	R:R:I69	R:R:V83	1.54	No	No	0	3	6
285	R:R:K301	R:R:V297	1.52	No	No	0	5	4
286	R:R:L98	R:R:S94	1.5	Yes	No	0	8	9
287	R:R:L18	R:R:V22	1.49	No	No	0	5	4
288	R:R:L201	R:R:V197	1.49	No	No	0	3	5
289	R:R:I252	R:R:I256	1.47	No	No	0	6	4
290	R:R:Q74	R:R:V166	1.43	No	No	0	4	3
291	R:R:K168	R:R:Q74	1.36	No	No	0	3	4
292	R:R:E153	R:R:L149	1.33	No	No	0	2	4
293	R:R:R154	R:R:S150	1.32	No	No	0	2	2
294	R:R:H78	R:R:M143	1.31	No	Yes	0	1	5
295	R:R:R123	R:R:V118	1.31	No	No	0	5	4
296	R:R:R122	R:R:T120	1.29	No	No	0	5	8
297	R:R:F144	R:R:L140	1.22	No	Yes	0	4	4
298	R:R:F204	R:R:L236	1.22	Yes	No	0	6	8
299	R:R:L238	R:R:R291	1.21	No	No	0	6	7
300	R:R:E153	R:R:R154	1.16	No	No	0	2	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y12	10.29	4	1	5
2	R:R:E16	8.748	5	1	6
3	R:R:S23	3.5025	4	2	8
4	R:R:N27	8.265	4	2	9
5	R:R:V30	4.4325	4	2	9
6	R:R:L40	7.7125	4	4	8
7	R:R:F47	4.12	4	0	8
8	R:R:L51	3.71	5	2	9
9	R:R:D55	6.31667	6	2	9
10	R:R:V62	4.96	4	0	6
11	R:R:I63	5.11	4	1	6
12	R:R:I67	4.01	4	1	6
13	R:R:F77	5.994	5	5	3
14	R:R:C85	3.7	4	7	6
15	R:R:I89	3.6675	4	7	5
16	R:R:Q92	5.304	5	3	6
17	R:R:I95	6.6875	4	1	8
18	R:R:L98	3.27	4	2	8
19	R:R:D104	7.25	4	6	9
20	R:R:Y106	7.128	5	0	7
21	R:R:R108	11.9725	4	6	8
22	R:R:L140	2.5175	4	7	4
23	R:R:M143	3.3625	4	7	5
24	R:R:W146	7.8125	4	3	6
25	R:R:S176	4.1175	4	3	5
26	R:R:Y179	6.85571	7	3	6
27	R:R:F183	4.496	5	3	5
28	R:R:W188	8.49	5	3	8
29	R:R:V189	3.2	4	1	5
30	R:R:Y200	6.025	6	0	9
31	R:R:F204	3.9	4	0	6
32	R:R:F243	7.4525	4	1	9
33	R:R:W247	8.548	5	1	8
34	R:R:L250	6.098	5	1	6
35	R:R:Y271	6.8975	4	1	3
36	R:R:I274	3.748	5	1	5
37	R:R:F275	6.235	4	1	5
38	R:R:H278	5.675	6	1	7
39	R:R:N284	6.1375	4	2	9
40	R:R:Y288	3.8	4	2	9
41	R:R:F295	6.025	4	2	9
42	L:L:?1	8.958	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I268	R:R:I272	13.2116	2.94	No	No	0	1	3
2	R:R:F275	R:R:I272	15.7635	7.54	Yes	No	0	5	3
3	R:R:E16	R:R:F275	20.7762	2.33	Yes	Yes	1	6	5
4	R:R:I274	R:R:Y12	15.1787	6.04	Yes	Yes	1	5	5
5	R:R:E16	R:R:H278	30.4751	14.77	Yes	Yes	1	6	7
6	R:R:S281	R:R:V58	35.8599	6.46	No	No	0	9	8
7	R:R:V58	R:R:V62	43.8689	6.41	No	Yes	0	8	6
8	R:R:H278	R:R:V62	29.6244	4.15	Yes	Yes	0	7	6
9	R:R:D55	R:R:S281	27.9117	8.83	Yes	No	2	9	9
10	R:R:D55	R:R:P285	47.2259	3.22	Yes	No	2	9	9
11	R:R:F295	R:R:V30	28.6485	9.18	Yes	Yes	2	9	9
12	R:R:P285	R:R:V30	45.9462	1.77	No	Yes	2	9	9
13	R:R:A52	R:R:V30	11.2938	3.39	No	Yes	0	9	9
14	R:R:A33	R:R:F295	20.1952	4.16	No	Yes	0	8	9
15	R:R:A33	R:R:T298	17.9812	1.68	No	No	0	8	6
16	R:R:L40	R:R:T298	11.2558	5.9	Yes	No	4	8	6
17	R:R:D104	R:R:F47	21.8471	7.17	Yes	Yes	0	9	8
18	R:R:F47	R:R:I128	27.0839	3.77	Yes	No	0	8	8
19	R:R:I128	R:R:S50	29.651	12.39	No	No	0	8	9
20	R:R:S50	R:R:W132	30.9232	4.94	No	No	0	9	9
21	R:R:S93	R:R:W132	32.0966	16.06	No	No	8	7	9
22	R:R:S135	R:R:S93	34.6941	4.89	No	No	0	8	7
23	R:R:Q92	R:R:S135	35.9359	5.78	Yes	No	0	6	8
24	R:R:N184	R:R:Q92	31.8574	2.64	No	Yes	0	5	6
25	R:R:M180	R:R:N184	14.8027	5.61	No	No	0	5	5
26	L:L:?1	R:R:M180	15.9306	5.6	Yes	No	0	0	5
27	L:L:?1	R:R:I274	13.7128	2.83	Yes	Yes	1	0	5
28	R:R:N280	R:R:N284	37.1055	10.9	No	Yes	0	9	9
29	R:R:N280	R:R:W247	43.3335	10.17	No	Yes	0	9	8
30	R:R:T91	R:R:W247	40.8803	3.64	No	Yes	0	6	8
31	L:L:?1	R:R:T91	41.2866	8.76	Yes	No	0	0	6
32	R:R:T277	R:R:W247	47.7006	3.64	No	Yes	1	7	8
33	L:L:?1	R:R:T277	41.2752	3.89	Yes	No	1	0	7
34	L:L:?1	R:R:V87	20.1078	6.88	Yes	No	0	0	6
35	R:R:C85	R:R:I89	48.0614	3.27	Yes	Yes	7	6	5
36	R:R:G139	R:R:I89	97.2772	3.53	No	Yes	0	6	5
37	R:R:G139	R:R:L88	98.6481	1.71	No	No	0	6	4
38	R:R:L88	R:R:Y179	100	3.52	No	Yes	0	4	6
39	R:R:I175	R:R:Y179	88.6151	3.63	No	Yes	3	3	6
40	R:R:F171	R:R:I175	91.7024	3.77	No	No	0	4	3
41	L:L:?1	R:R:F171	93.6619	24.12	Yes	No	0	0	4
42	R:R:C85	R:R:M143	43.5271	6.48	Yes	Yes	7	6	5
43	R:R:L81	R:R:M143	80.8719	2.83	No	Yes	0	5	5
44	R:R:L81	R:R:N147	77.701	5.49	No	No	0	5	6
45	R:R:F77	R:R:N147	61.6869	6.04	Yes	No	5	3	6
46	R:R:F77	R:R:V174	39.5929	6.55	Yes	No	0	3	3
47	R:R:C80	R:R:V174	36.3764	6.83	No	No	0	9	3
48	R:R:C169	R:R:C80	33.1105	7.28	No	No	0	9	9
49	R:R:C169	R:R:T75	23.256	3.38	No	No	0	9	7
50	R:R:I89	R:R:L140	46.4474	2.85	Yes	Yes	7	5	4
51	R:R:L140	R:R:M143	43.4246	2.83	Yes	Yes	7	4	5
52	R:R:T75	R:R:T79	19.9559	4.71	No	No	0	7	5
53	R:R:T79	R:R:Y76	16.6483	2.5	No	No	0	5	6
54	R:R:V166	R:R:Y76	10.0103	3.79	No	No	0	3	6
55	R:R:L149	R:R:N147	12.828	4.12	No	No	5	4	6
56	R:R:F77	R:R:V152	13.0748	2.62	Yes	No	5	3	1
57	R:R:Q92	R:R:V138	12.8166	5.73	Yes	No	3	6	5
58	R:R:Q92	R:R:W188	14.4723	4.38	Yes	Yes	3	6	8
59	R:R:I95	R:R:W247	13.8116	15.27	Yes	Yes	1	8	8
60	R:R:N184	R:R:V189	19.4167	2.96	No	Yes	0	5	5
61	R:R:F243	R:R:W247	47.5411	10.02	Yes	Yes	1	9	8
62	R:R:I199	R:R:Y200	26.4953	2.42	No	Yes	0	6	9
63	R:R:L240	R:R:Y200	44.3018	5.86	No	Yes	0	8	9
64	R:R:L240	R:R:M196	47.7614	2.83	No	No	0	8	8
65	R:R:F243	R:R:M196	49.2994	7.46	Yes	No	0	9	8
66	R:R:D104	R:R:Y115	15.1483	5.75	Yes	No	6	9	7
67	R:R:I199	R:R:Y106	19.9787	2.42	No	Yes	0	6	7
68	R:R:V118	R:R:V119	12.7103	3.21	No	No	0	4	7
69	R:R:V119	R:R:Y115	14.085	13.88	No	No	0	7	7
70	R:R:F183	R:R:Y179	22.918	8.25	Yes	Yes	3	5	6
71	R:R:P165	R:R:V152	10.0027	3.53	No	No	0	5	1
72	L:L:?1	R:R:E172	14.0888	10.5	Yes	No	0	0	4
73	R:R:E172	R:R:M177	11.1229	2.71	No	No	0	4	3
74	R:R:M177	R:R:N254	13.9331	2.8	No	No	0	3	5
75	L:L:?1	R:R:N254	12.7635	9.97	Yes	No	1	0	5
76	R:R:L258	R:R:M177	21.5737	2.83	No	No	0	4	3
77	R:R:L258	R:R:V181	14.4116	5.96	No	No	0	4	4
78	R:R:L236	R:R:Y200	14.9812	8.21	No	Yes	0	8	9
79	R:R:F204	R:R:L236	13.3369	1.22	Yes	No	0	6	8
80	R:R:I268	R:R:P266	10.6292	1.69	No	No	0	1	4
81	R:R:E153	R:R:L149	10.0103	1.33	No	No	0	2	4
82	L:L:?1	R:R:H278	46.3259	4.24	Yes	Yes	1	0	7
83	R:R:D55	R:R:N284	27.513	4.04	Yes	Yes	2	9	9
84	R:R:V62	R:R:V87	19.3218	4.81	Yes	No	0	6	6
85	R:R:I95	R:R:V189	17.3433	3.07	Yes	Yes	1	8	5
86	R:R:F183	R:R:V138	12.285	2.62	Yes	No	3	5	5
87	R:R:F183	R:R:W188	13.4698	6.01	Yes	Yes	3	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E16	R:R:Y12	15.71	1	Yes	Yes	6	5	2	2
R:R:I274	R:R:Y12	6.04	1	Yes	Yes	5	5	1	2
R:R:E16	R:R:I63	8.2	1	Yes	Yes	6	6	2	2
R:R:E16	R:R:H278	14.77	1	Yes	Yes	6	7	2	1
R:R:V62	R:R:V87	4.81	0	Yes	No	6	6	2	1
R:R:H278	R:R:V62	4.15	1	Yes	Yes	7	6	1	2
R:R:H278	R:R:I63	3.98	1	Yes	Yes	7	6	1	2
R:R:A66	R:R:H278	2.93	0	No	Yes	7	7	2	1
R:R:A84	R:R:F171	2.77	0	No	No	4	4	2	1
L:L:?1	R:R:V87	6.88	1	Yes	No	0	6	0	1
R:R:T91	R:R:W247	3.64	0	No	Yes	6	8	1	2
L:L:?1	R:R:T91	8.76	1	Yes	No	0	6	0	1
R:R:E170	R:R:E172	6.34	0	No	No	4	4	2	1
R:R:F171	R:R:I175	3.77	0	No	No	4	3	1	2
L:L:?1	R:R:F171	24.12	1	Yes	No	0	4	0	1
R:R:E172	R:R:M177	2.71	0	No	No	4	3	1	2
L:L:?1	R:R:E172	10.5	1	Yes	No	0	4	0	1
R:R:M177	R:R:N254	2.8	0	No	No	3	5	2	1
R:R:M180	R:R:N184	5.61	0	No	No	5	5	1	2
L:L:?1	R:R:M180	5.6	1	Yes	No	0	5	0	1
R:R:T277	R:R:W247	3.64	1	No	Yes	7	8	1	2
R:R:L250	R:R:N254	2.75	1	Yes	No	6	5	1	1
R:R:A273	R:R:L250	4.73	0	No	Yes	5	6	2	1
R:R:I274	R:R:L250	2.85	1	Yes	Yes	5	6	1	1
R:R:L250	R:R:T277	7.37	1	Yes	No	6	7	1	1
L:L:?1	R:R:L250	12.79	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N254	9.97	1	Yes	No	0	5	0	1
R:R:I274	R:R:T270	3.04	1	Yes	No	5	4	1	2
R:R:H278	R:R:I274	3.98	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:I274	2.83	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T277	3.89	1	Yes	No	0	7	0	1
L:L:?1	R:R:H278	4.24	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6D9H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.48
Number of Linked Nodes	259
Number of Links	300
Number of Hubs	42
Number of Links mediated by Hubs	151
Number of Communities	8
Number of Nodes involved in Communities	72
Number of Links involved in Communities	103

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	63750
Length Of Smallest Path	3
Average Path Length	15.2991
Length of Longest Path	34
Minimum Path Strength	1.24
Average Path Strength	5.61526
Maximum Path Strength	19.8
Minimum Path Correlation	0.7
Average Path Correlation	0.921439
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.2324
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1241
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • binding • nucleoside binding • heterocyclic compound binding • carbohydrate derivative binding • purine nucleoside binding • small molecule binding • G protein-coupled adenosine receptor activity • protein binding • heat shock protein binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • signaling receptor binding • G protein-coupled receptor binding • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of long-term synaptic potentiation • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • negative regulation of biological process • long-term synaptic potentiation • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • regulation of signaling • positive regulation of synaptic transmission • regulation of trans-synaptic signaling • regulation of long-term synaptic potentiation • regulation of cell communication • positive regulation of signaling • regulation of localization • nitrogen compound transport • regulation of transport • transport • regulation of nucleobase-containing compound transport • nucleoside transport • positive regulation of nucleoside transport • carbohydrate derivative transport • positive regulation of nucleobase-containing compound transport • establishment of localization • localization • positive regulation of transport • regulation of nucleoside transport • nucleobase-containing compound transport • import into cell • phagocytosis • endocytosis • vesicle-mediated transport • chemical homeostasis • homeostatic process • triglyceride homeostasis • acylglycerol homeostasis • lipid homeostasis • regulation of body fluid levels • multicellular organismal process • secretion by tissue • secretion • mucus secretion • body fluid secretion • system process • nervous system process • cognition • establishment of protein localization • cellular localization • establishment of protein localization to membrane • protein targeting • localization within membrane • protein targeting to membrane • renal system process • regulation of renal system process • regulation of blood pressure • regulation of system process • regulation of glomerular filtration • regulation of systemic arterial blood pressure • circulatory system process • renal system process involved in regulation of blood volume • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • glomerular filtration • blood circulation • renal filtration • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • positive regulation of potassium ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • negative regulation of signaling • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • negative regulation of synaptic transmission, glutamatergic • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • circadian sleep/wake cycle, non-REM sleep • regulation of behavior • sleep • circadian sleep/wake cycle, sleep • rhythmic process • negative regulation of behavior • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of circadian rhythm • negative regulation of circadian sleep/wake cycle, non-REM sleep • behavior • circadian behavior • regulation of circadian sleep/wake cycle, sleep • negative regulation of multicellular organismal process • circadian sleep/wake cycle process • negative regulation of locomotion • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • negative regulation of leukocyte migration • negative regulation of immune system process • immune system process • regulation of cell migration • negative regulation of cell motility • cell migration • regulation of immune system process • cell motility • negative regulation of cell migration • inorganic ion homeostasis • intracellular calcium ion homeostasis • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • negative regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • positive regulation of phosphorus metabolic process • positive regulation of dephosphorylation • regulation of dephosphorylation • dephosphorylation • positive regulation of phosphate metabolic process • positive regulation of metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • phosphorus metabolic process • negative regulation of neurotrophin production • neurotrophin production • regulation of neurotrophin production • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • actin filament-based process • cardiac muscle cell contraction • regulation of cardiac muscle contraction • actin filament-based movement • muscle contraction • muscle system process • regulation of muscle system process • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of muscle contraction • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • respiratory gaseous exchange by respiratory system • respiratory system process • regulation of respiratory gaseous exchange • regulation of respiratory system process • regulation of respiratory gaseous exchange by nervous system process • regulation of nervous system process • regulation of sensory perception • regulation of sensory perception of pain • positive regulation of peptide secretion • regulation of peptide secretion • regulation of peptide transport • regulation of secretion • peptide transport • peptide secretion • positive regulation of secretion • amide transport • negative regulation of amino acid transport • negative regulation of amine transport • regulation of glutamate secretion • negative regulation of transport • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of glutamate secretion • regulation of amino acid transport • glutamate secretion • negative regulation of secretion by cell • organic anion transport • carboxylic acid transport • export from cell • organic acid transport • amino acid transport • amine transport • acidic amino acid transport • negative regulation of organic acid transport • regulation of organic acid transport • dicarboxylic acid transport • regulation of amine transport • positive regulation of catabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • regulation of hormone secretion • hormone secretion • signal release • negative regulation of hormone secretion • regulation of hormone levels • hormone transport • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic nucleotide receptor signaling pathway • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • excitatory postsynaptic potential • regulation of membrane potential • regulation of mucus secretion • negative regulation of mucus secretion • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • fatty acid homeostasis • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • regulation of defense response • negative regulation of acute inflammatory response • regulation of response to external stimulus • defense response • negative regulation of inflammatory response • negative regulation of response to stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • regulation of acute inflammatory response • inflammatory response • acute inflammatory response • negative regulation of long-term synaptic depression • long-term synaptic depression • regulation of long-term synaptic depression • apoptotic signaling pathway • multicellular organismal-level homeostasis • temperature homeostasis • negative regulation of systemic arterial blood pressure • negative regulation of blood pressure • response to purine-containing compound • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • presynapse • presynaptic active zone • presynaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • axon • axon terminus • distal axon • calyx of Held • neuron projection terminus • neuron spine • dendritic spine • cell leading edge • axolemma • leading edge membrane • neuron projection membrane • main axon • cell projection membrane • cell body • neuronal cell body • membrane-bounded organelle • organelle • cilium • terminal bouton • neuron to neuron synapse • asymmetric synapse • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • midbody • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • hippocampal mossy fiber to CA3 synapse • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	Ado
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30542
Sequence	>6D9H_nogp_Chain_R I S A F Q A A Y I G I E V L I A L V S V P G N V L V I W A V K V N Q A L R D A T F C F I V S L A V A D V A V G A L V I P L A I L I N I G P Q T Y F H T C L M V A C P V L I L T Q S S I L A L L A I A V D R Y L R V K I P L R Y K M V V T P R R A A V A I A G C W I L S F V V G L T P M F G W N N L S A V E R A W A A N G S M G E P V I K C E F E K V I S M E Y M V Y F N F F V W V L P P L L L M V L I Y L E V F Y L I R K Q L N K Q K Y Y G K E L K I A K S L A L I L F L F A L S W L P L H I L N C I T L F C P S C H K P S I L T Y I A I F L T H G N S A M N P I V Y A F R I Q K F R V T F L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZMF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	A1L10	-	-	3.6	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521	Gi2/β1/γ2	3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521		3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	5UEN	A	Nucleotide	Adenosine	A₁	Homo sapiens	DU172	-	-	3.2	2017-03-01	doi.org/10.1016/j.cell.2017.01.042
	5N2S	A	Nucleotide	Adenosine	A₁	Homo sapiens	PSB36	-	-	3.3	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	6D9H	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-	Gi2/β1/γ2	3.6	2018-06-20	doi.org/10.1038/s41586-018-0236-6
	6D9H (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-		3.6	2018-06-20	doi.org/10.1038/s41586-018-0236-6
	7LD4	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-	Gi2/β1/γ2	3.3	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	7LD4 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	-		3.3	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	8Y52	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y52 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-		2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	doi.org/10.1038/s41467-017-01240-w
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; AP8	-	3.22	2017-06-07	doi.org/10.1038/nsmb.3417
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	doi.org/10.1038/nsmb.3417
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	doi.org/10.1038/nature13494
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA	Gi1/β1/γ2	3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA		3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	8YFS	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2025-03-05	To be published
	8YFS (No Gprot)	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-		2.8	2025-03-05	To be published
	9UST	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.02	2025-07-02	To be published
	9UST (No Gprot)	A	Orphan	Orphan	MRGPRE	Equus quagga	A1D6H	-		3.02	2025-07-02	To be published
	8IEB	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	3.03	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	Go/β1/γ2	3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-		3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEI	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.62	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEP	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.61	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294

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