psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A82	R:R:L30	4.73	No	No	0	6	7
2	R:R:L30	R:R:W318	6.83	No	Yes	0	7	5
3	R:R:L33	R:R:M78	4.24	No	Yes	0	7	7
4	R:R:I34	R:R:M78	4.37	No	Yes	0	6	7
5	R:R:D70	R:R:N41	13.46	Yes	No	0	9	9
6	R:R:N41	R:R:P328	6.52	No	No	0	9	9
7	R:R:P328	R:R:V44	3.53	No	No	0	9	9
8	R:R:F341	R:R:V44	5.24	No	No	0	7	9
9	R:R:I64	R:R:V48	4.61	No	No	0	6	8
10	R:R:L344	R:R:R50	3.64	No	No	0	6	6
11	R:R:F51	R:R:H53	6.79	Yes	No	0	6	6
12	R:R:A340	R:R:F51	5.55	No	Yes	0	7	6
13	R:R:F51	R:R:T343	5.19	Yes	No	0	6	4
14	R:R:H53	R:R:L54	9	No	No	2	6	9
15	R:R:D336	R:R:H53	3.78	Yes	No	2	7	6
16	R:R:D336	R:R:L54	5.43	Yes	No	2	7	9
17	R:R:K57	R:R:N60	5.6	No	No	0	5	9
18	R:R:M135	R:R:V58	4.56	Yes	No	0	7	6
19	R:R:P137	R:R:V58	5.3	No	No	0	1	6
20	R:R:N60	R:R:T59	4.39	No	No	0	9	8
21	R:R:D120	R:R:T59	5.78	Yes	No	3	9	8
22	R:R:T59	R:R:Y131	4.99	No	Yes	3	8	7
23	R:R:F337	R:R:N60	6.04	Yes	No	0	9	9
24	R:R:A140	R:R:F61	4.16	No	No	0	7	4
25	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
26	R:R:D120	R:R:F62	10.75	Yes	Yes	0	9	8
27	R:R:F62	R:R:L143	3.65	Yes	No	0	8	7
28	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
29	R:R:N113	R:R:S65	8.94	No	No	0	8	9
30	R:R:I144	R:R:S65	6.19	No	No	0	8	9
31	R:R:S65	R:R:W148	4.94	No	No	0	9	9
32	R:R:L66	R:R:S69	4.5	Yes	No	1	9	8
33	R:R:D70	R:R:L66	8.14	Yes	Yes	1	9	9
34	R:R:L114	R:R:L66	5.54	No	Yes	1	9	9
35	R:R:L66	R:R:N327	6.87	Yes	No	1	9	9
36	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
37	R:R:D70	R:R:S69	4.42	Yes	No	1	9	8
38	R:R:S110	R:R:S69	4.89	No	No	1	9	8
39	R:R:D70	R:R:S110	4.42	Yes	No	1	9	9
40	R:R:D70	R:R:S324	11.78	Yes	No	0	9	9
41	R:R:D70	R:R:N327	9.42	Yes	No	1	9	9
42	R:R:L72	R:R:L76	4.15	No	No	0	7	6
43	R:R:S324	R:R:V73	4.85	No	No	0	9	8
44	R:R:F102	R:R:L76	6.09	No	No	0	5	6
45	R:R:V77	R:R:W99	4.9	No	Yes	1	8	5
46	R:R:D103	R:R:V77	4.38	Yes	No	1	7	8
47	R:R:V77	R:R:W321	6.13	No	Yes	1	8	7
48	R:R:M78	R:R:W318	5.82	Yes	Yes	1	7	5
49	R:R:M78	R:R:W321	3.49	Yes	Yes	1	7	7
50	R:R:F92	R:R:W80	8.02	No	No	0	6	5
51	R:R:F95	R:R:W80	5.01	No	No	1	5	5
52	R:R:W80	R:R:W99	5.62	No	Yes	1	5	5
53	R:R:E85	R:R:K81	5.4	No	Yes	1	4	6
54	R:R:K81	R:R:W99	9.28	Yes	Yes	1	6	5
55	R:R:D314	R:R:K81	8.3	No	Yes	1	4	6
56	R:R:K81	R:R:W318	6.96	Yes	Yes	1	6	5
57	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
58	L:L:?1	R:R:K81	3.98	Yes	Yes	1	0	6
59	R:R:D314	R:R:E85	7.8	No	No	1	4	4
60	R:R:F89	R:R:P91	5.78	No	No	0	4	1
61	R:R:F92	R:R:W90	15.03	No	Yes	0	6	8
62	R:R:C96	R:R:W90	5.22	No	Yes	1	9	8
63	R:R:W90	R:R:W99	4.69	Yes	Yes	1	8	5
64	R:R:C186	R:R:W90	10.45	No	Yes	1	9	8
65	R:R:F92	R:R:P91	8.67	No	No	0	6	1
66	R:R:F95	R:R:I98	3.77	No	No	0	5	6
67	R:R:F95	R:R:W99	5.01	No	Yes	1	5	5
68	R:R:C186	R:R:C96	7.28	No	No	1	9	9
69	R:R:I98	R:R:Q160	4.12	No	No	0	6	5
70	R:R:W321	R:R:W99	3.75	Yes	Yes	1	7	5
71	L:L:?1	R:R:W99	7.24	Yes	Yes	1	0	5
72	L:L:?1	R:R:V100	6.31	Yes	No	0	0	5
73	R:R:A101	R:R:F156	5.55	No	Yes	0	6	5
74	R:R:A101	R:R:V159	5.09	No	Yes	0	6	5
75	R:R:F102	R:R:F156	6.43	No	Yes	0	5	5
76	R:R:D103	R:R:S107	4.42	Yes	No	0	7	7
77	R:R:D103	R:R:W321	12.28	Yes	Yes	1	7	7
78	L:L:?1	R:R:D103	9.58	Yes	Yes	1	0	7
79	R:R:I104	R:R:Y194	4.84	No	Yes	0	6	7
80	L:L:?1	R:R:I104	13.1	Yes	No	0	0	6
81	R:R:M105	R:R:S155	6.13	No	No	4	5	7
82	R:R:F156	R:R:M105	7.46	Yes	No	4	5	5
83	R:R:S107	R:R:W285	4.94	No	Yes	0	7	8
84	R:R:S151	R:R:T108	4.8	No	No	0	8	6
85	R:R:I154	R:R:T108	4.56	No	No	0	5	6
86	R:R:S202	R:R:T108	9.59	No	No	0	6	6
87	R:R:A109	R:R:W148	7.78	No	No	0	7	9
88	R:R:A109	R:R:S151	3.42	No	No	0	7	8
89	R:R:F281	R:R:I111	5.02	Yes	No	1	9	8
90	R:R:I111	R:R:W285	7.05	No	Yes	1	8	8
91	R:R:F281	R:R:L114	3.65	Yes	No	1	9	9
92	R:R:L114	R:R:Y331	7.03	No	Yes	1	9	9
93	R:R:C115	R:R:P206	3.77	No	Yes	0	7	9
94	R:R:C115	R:R:I209	6.55	No	No	0	7	6
95	R:R:I117	R:R:R121	3.76	No	No	1	9	9
96	R:R:I117	R:R:Y331	3.63	No	Yes	1	9	9
97	R:R:S118	R:R:T213	4.8	No	No	0	8	7
98	R:R:S118	R:R:Y214	5.09	No	Yes	0	8	9
99	R:R:D120	R:R:Y131	9.2	Yes	Yes	3	9	7
100	R:R:D120	R:R:M135	4.16	Yes	Yes	3	9	7
101	R:R:R121	R:R:Y214	4.12	No	Yes	0	9	9
102	R:R:R121	R:R:Y331	6.17	No	Yes	1	9	9
103	R:R:S126	R:R:Y122	8.9	No	Yes	0	7	8
104	R:R:T213	R:R:Y122	6.24	No	Yes	0	7	8
105	R:R:R216	R:R:Y122	11.32	No	Yes	0	5	8
106	R:R:I217	R:R:Y122	3.63	No	Yes	0	9	8
107	R:R:S127	R:R:W123	4.94	No	Yes	0	6	4
108	R:R:W123	R:R:Y131	7.72	Yes	Yes	3	4	7
109	R:R:K134	R:R:W123	4.64	No	Yes	0	5	4
110	R:R:M135	R:R:W123	4.65	Yes	Yes	3	7	4
111	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
112	R:R:I125	R:R:I217	4.42	No	No	0	8	9
113	R:R:R130	R:R:S127	3.95	No	No	0	5	6
114	R:R:E132	R:R:F129	3.5	No	No	0	5	7
115	R:R:M135	R:R:Y131	15.57	Yes	Yes	3	7	7
116	R:R:K134	R:R:R133	7.43	No	No	0	5	4
117	R:R:P137	R:R:T136	3.5	No	No	0	1	8
118	R:R:K138	R:R:T136	6.01	No	No	0	4	8
119	R:R:F156	R:R:S155	6.61	Yes	No	4	5	7
120	R:R:F156	R:R:Q160	8.2	Yes	No	0	5	5
121	R:R:I157	R:R:P158	5.08	No	No	0	6	6
122	R:R:P158	R:R:Y194	5.56	No	Yes	0	6	7
123	R:R:Q160	R:R:V159	5.73	No	Yes	0	5	5
124	R:R:H164	R:R:V159	12.45	Yes	Yes	0	5	5
125	R:R:L161	R:R:W163	13.67	No	No	0	4	6
126	R:R:H164	R:R:K165	18.34	Yes	No	0	5	3
127	R:R:H164	R:R:L190	3.86	Yes	Yes	0	5	4
128	R:R:H164	R:R:Y194	6.53	Yes	Yes	0	5	7
129	R:R:K165	R:R:S188	4.59	No	No	0	3	5
130	R:R:A166	R:R:P168	3.74	No	No	0	2	1
131	R:R:D187	R:R:N185	4.04	No	No	0	5	4
132	R:R:L190	R:R:N292	4.12	Yes	Yes	1	4	6
133	L:L:?1	R:R:L190	7.82	Yes	Yes	1	0	4
134	R:R:F297	R:R:R192	18.17	No	No	0	6	4
135	R:R:S198	R:R:Y194	10.17	No	Yes	0	7	7
136	R:R:A195	R:R:P296	3.74	No	No	0	5	5
137	L:L:?1	R:R:S198	5.3	Yes	No	0	0	7
138	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
139	R:R:N292	R:R:S199	5.96	Yes	No	0	6	7
140	R:R:C293	R:R:S199	3.44	No	No	0	6	7
141	R:R:F289	R:R:S202	3.96	Yes	No	0	7	6
142	R:R:F203	R:R:Y204	6.19	Yes	No	0	8	5
143	R:R:F203	R:R:W285	4.01	Yes	Yes	1	8	8
144	R:R:F203	R:R:L286	3.65	Yes	Yes	0	8	6
145	R:R:F203	R:R:F289	21.43	Yes	Yes	1	8	7
146	R:R:F281	R:R:M210	7.46	Yes	No	0	9	8
147	R:R:L274	R:R:Y214	3.52	No	Yes	0	8	9
148	R:R:I277	R:R:Y214	6.04	No	Yes	0	8	9
149	R:R:M278	R:R:Y214	3.59	No	Yes	0	8	9
150	R:R:R219	R:R:Y218	8.23	No	Yes	5	4	7
151	R:R:Q222	R:R:Y218	5.64	No	Yes	5	6	7
152	R:R:V270	R:R:Y218	3.79	No	Yes	0	8	7
153	R:R:L271	R:R:Y218	9.38	No	Yes	0	7	7
154	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
155	R:R:Q222	R:R:R219	8.18	No	No	5	6	4
156	R:R:Q222	R:R:R226	3.5	No	No	0	6	5
157	R:R:K223	R:R:R226	3.71	No	No	0	5	5
158	R:R:Q224	R:R:R227	10.51	No	No	0	7	5
159	R:R:I225	R:R:R266	3.76	No	No	0	5	6
160	R:R:E267	R:R:I225	4.1	No	No	0	8	5
161	R:R:I228	R:R:R266	5.01	No	No	0	7	6
162	R:R:F264	R:R:T268	7.78	No	No	0	5	5
163	R:R:I330	R:R:V280	4.61	No	No	0	8	7
164	R:R:F281	R:R:W285	6.01	Yes	Yes	1	9	8
165	R:R:C284	R:R:N323	9.45	No	No	0	9	9
166	R:R:F288	R:R:W285	7.02	Yes	Yes	1	7	8
167	R:R:F289	R:R:W285	5.01	Yes	Yes	1	7	8
168	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
169	R:R:N323	R:R:W285	6.78	No	Yes	0	9	8
170	R:R:I290	R:R:L286	7.14	No	Yes	0	7	6
171	R:R:F316	R:R:P287	10.11	No	No	0	5	9
172	R:R:F288	R:R:F289	11.79	Yes	Yes	1	7	7
173	R:R:F288	R:R:N292	4.83	Yes	Yes	1	7	6
174	R:R:F288	R:R:F313	5.36	Yes	Yes	0	7	4
175	L:L:?1	R:R:F288	12.04	Yes	Yes	1	0	7
176	L:L:?1	R:R:F289	5.16	Yes	Yes	1	0	7
177	R:R:F313	R:R:L291	3.65	Yes	No	0	4	5
178	L:L:?1	R:R:N292	7.75	Yes	Yes	1	0	6
179	R:R:F313	R:R:L295	7.31	Yes	No	0	4	3
180	R:R:I308	R:R:T312	4.56	No	No	0	4	4
181	R:R:D309	R:R:T312	4.34	No	No	0	4	4
182	R:R:F316	R:R:T312	3.89	No	No	0	5	4
183	R:R:F313	R:R:V317	3.93	Yes	No	0	4	6
184	R:R:F319	R:R:V315	3.93	No	No	0	7	4
185	R:R:F316	R:R:F319	4.29	No	No	0	5	7
186	R:R:V317	R:R:W321	7.36	No	Yes	0	6	7
187	R:R:W318	R:R:W321	10.31	Yes	Yes	1	5	7
188	R:R:N323	R:R:N327	6.81	No	No	0	9	9
189	R:R:L326	R:R:S325	4.5	No	Yes	0	6	6
190	R:R:I330	R:R:Y331	8.46	No	Yes	0	8	9
191	R:R:A332	R:R:F337	5.55	No	Yes	0	6	9
192	R:R:F333	R:R:R338	12.83	No	No	0	8	8
193	R:R:D336	R:R:N334	10.77	Yes	No	2	7	8
194	R:R:F337	R:R:N334	9.67	Yes	No	2	9	8
195	R:R:D336	R:R:F337	4.78	Yes	Yes	2	7	9
196	R:R:G346	R:R:Y348	5.79	No	No	0	5	3
197	R:R:A67	R:R:V44	3.39	No	No	0	9	9
198	R:R:I111	R:R:P206	3.39	No	Yes	0	8	9
199	R:R:I205	R:R:P206	3.39	No	Yes	0	5	9
200	R:R:A74	R:R:T37	3.36	No	No	0	7	7
201	R:R:L112	R:R:P206	3.28	No	Yes	0	5	9
202	R:R:L286	R:R:P287	3.28	Yes	No	0	6	9
203	R:R:C293	R:R:I196	3.27	No	No	0	6	6
204	R:R:A27	R:R:I86	3.25	No	No	0	6	5
205	R:R:F141	R:R:F61	3.22	No	No	0	3	4
206	R:R:S325	R:R:T37	3.2	Yes	No	0	6	7
207	R:R:C106	R:R:L72	3.17	No	No	0	7	7
208	R:R:A74	R:R:L38	3.15	No	No	0	7	7
209	R:R:A147	R:R:L112	3.15	No	No	0	7	5
210	R:R:A195	R:R:L190	3.15	No	Yes	0	5	4
211	R:R:I205	R:R:V200	3.07	No	No	0	5	4
212	R:R:K57	R:R:S56	3.06	No	No	0	5	8
213	R:R:K165	R:R:S162	3.06	No	No	0	3	5
214	R:R:L33	R:R:S325	3	No	Yes	0	7	6
215	R:R:L76	R:R:V75	2.98	No	No	0	6	5
216	R:R:L286	R:R:V282	2.98	Yes	No	0	6	7
217	R:R:N97	R:R:V159	2.96	No	Yes	0	6	5
218	R:R:L153	R:R:T149	2.95	No	No	0	4	3
219	R:R:I125	R:R:I220	2.94	No	No	0	8	6
220	R:R:F61	R:R:P137	2.89	No	No	0	4	1
221	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
222	R:R:A47	R:R:F341	2.77	No	No	0	8	7
223	R:R:A87	R:R:F89	2.77	No	No	0	5	4
224	R:R:L112	R:R:L150	2.77	No	No	0	5	4
225	R:R:L71	R:R:N41	2.75	No	No	0	8	9
226	R:R:P158	R:R:W163	2.7	No	No	0	6	6
227	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
228	R:R:F281	R:R:V207	2.62	Yes	No	0	9	7
229	R:R:A84	R:R:W90	2.59	No	Yes	0	5	8
230	R:R:F297	R:R:I196	2.51	No	No	0	6	6
231	R:R:F341	R:R:L43	2.44	No	No	0	7	7
232	R:R:F51	R:R:L344	2.44	Yes	No	0	6	6
233	R:R:E232	R:R:R266	2.33	No	No	0	3	6
234	R:R:N185	R:R:W90	2.26	No	Yes	0	4	8
235	R:R:G40	R:R:P328	2.03	No	No	0	9	9
236	R:R:C347	R:R:G346	1.96	No	No	0	9	5
237	R:R:A87	R:R:G88	1.95	No	No	0	5	4
238	R:R:G279	R:R:V282	1.84	No	No	0	5	7
239	R:R:C283	R:R:C284	1.82	No	No	0	5	9
240	R:R:A67	R:R:C45	1.81	No	No	0	9	7
241	R:R:P128	R:R:S127	1.78	No	No	0	8	6
242	R:R:P91	R:R:V83	1.77	No	No	0	1	4
243	R:R:G40	R:R:L39	1.71	No	No	0	9	4
244	R:R:A322	R:R:S325	1.71	No	Yes	0	4	6
245	R:R:A332	R:R:V63	1.7	No	No	0	6	8
246	R:R:A221	R:R:V270	1.7	No	No	0	9	8
247	R:R:M78	R:R:P79	1.68	Yes	No	0	7	8
248	R:R:A139	R:R:T136	1.68	No	No	0	6	8
249	R:R:K167	R:R:P168	1.67	No	No	0	2	1
250	R:R:C28	R:R:I24	1.64	No	No	0	5	6
251	R:R:S118	R:R:V119	1.62	No	No	0	8	6
252	R:R:S275	R:R:V276	1.62	No	No	0	6	7
253	R:R:S191	R:R:T193	1.6	No	No	0	5	4
254	R:R:S197	R:R:T193	1.6	No	No	0	4	4
255	R:R:T26	R:R:V22	1.59	No	No	0	5	4
256	R:R:T213	R:R:V212	1.59	No	No	0	7	4
257	R:R:A46	R:R:L344	1.58	No	No	0	5	6
258	R:R:I24	R:R:S21	1.55	No	No	0	6	4
259	R:R:I142	R:R:V146	1.54	No	No	0	1	3
260	R:R:I225	R:R:V270	1.54	No	No	0	5	8
261	R:R:M105	R:R:V152	1.52	No	No	0	5	4
262	R:R:K272	R:R:V276	1.52	No	No	0	7	7
263	R:R:I277	R:R:T273	1.52	No	No	0	8	9
264	R:R:K272	R:R:T273	1.5	No	No	0	7	9
265	R:R:K339	R:R:T343	1.5	No	No	0	5	4
266	R:R:L72	R:R:V68	1.49	No	No	0	7	6
267	R:R:L150	R:R:V146	1.49	No	No	0	4	3
268	R:R:N311	R:R:S310	1.49	No	No	0	1	1
269	R:R:N240	R:R:V236	1.48	No	No	0	4	4
270	R:R:L30	R:R:T26	1.47	No	No	0	7	5
271	R:R:L71	R:R:T42	1.47	No	No	0	8	5
272	R:R:I290	R:R:I294	1.47	No	No	0	7	5
273	R:R:I211	R:R:M278	1.46	No	No	0	6	8
274	R:R:I157	R:R:L153	1.43	No	No	0	6	4
275	R:R:A230	R:R:R233	1.38	No	No	0	4	1
276	R:R:D309	R:R:N311	1.35	No	No	0	4	1
277	R:R:F264	R:R:S263	1.32	No	No	0	5	5
278	R:R:R55	R:R:V48	1.31	No	No	0	8	8
279	R:R:S191	R:R:Y194	1.27	No	Yes	0	5	7
280	R:R:E132	R:R:R133	1.16	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	4.9925	4	0	6
2	R:R:F62	6.165	4	0	8
3	R:R:L66	5.714	5	1	9
4	R:R:D70	8.60667	6	1	9
5	R:R:M78	3.92	5	1	7
6	R:R:K81	6.42667	6	1	6
7	R:R:W90	6.15	7	1	8
8	R:R:W99	5.78429	7	1	5
9	R:R:D103	7.665	4	1	7
10	R:R:D120	7.4725	4	3	9
11	R:R:Y122	7.5225	4	0	8
12	R:R:W123	5.4875	4	3	4
13	R:R:Y131	9.098	5	3	7
14	R:R:M135	7.235	4	3	7
15	R:R:F156	6.85	5	4	5
16	R:R:V159	6.5575	4	0	5
17	R:R:H164	10.295	4	0	5
18	R:R:L190	4.7375	4	1	4
19	R:R:Y194	5.674	5	0	7
20	R:R:F203	8.82	4	1	8
21	R:R:P206	3.4575	4	0	9
22	R:R:Y214	4.472	5	0	9
23	R:R:Y218	6.112	5	5	7
24	R:R:F281	4.952	5	1	9
25	R:R:W285	6.1575	8	1	8
26	R:R:L286	4.2625	4	0	6
27	R:R:F288	8.208	5	1	7
28	R:R:F289	8.77167	6	1	7
29	R:R:N292	5.665	4	1	6
30	R:R:F313	5.0625	4	0	4
31	R:R:W318	7.48	4	1	5
32	R:R:W321	6.85143	7	1	7
33	R:R:S325	3.1025	4	0	6
34	R:R:Y331	5.762	5	1	9
35	R:R:D336	6.19	4	2	7
36	R:R:F337	5.732	5	2	9
37	L:L:?1	7.828	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L33	R:R:M78	23.5814	4.24	No	Yes	0	7	7
2	R:R:K81	R:R:W318	14.6408	6.96	Yes	Yes	1	6	5
3	L:L:?1	R:R:K81	24.9974	3.98	Yes	Yes	1	0	6
4	L:L:?1	R:R:F288	41.7571	12.04	Yes	Yes	1	0	7
5	R:R:F288	R:R:W285	55.1008	7.02	Yes	Yes	1	7	8
6	R:R:N323	R:R:W285	41.0284	6.78	No	Yes	0	9	8
7	R:R:N323	R:R:N327	36.5013	6.81	No	No	0	9	9
8	R:R:D70	R:R:N327	30.6873	9.42	Yes	No	1	9	9
9	L:L:?1	R:R:F289	100	5.16	Yes	Yes	1	0	7
10	R:R:F289	R:R:W285	67.1783	5.01	Yes	Yes	1	7	8
11	R:R:D103	R:R:W321	15.0801	12.28	Yes	Yes	1	7	7
12	R:R:D70	R:R:N41	25.2972	13.46	Yes	No	0	9	9
13	R:R:N41	R:R:P328	19.1111	6.52	No	No	0	9	9
14	R:R:P328	R:R:V44	12.832	3.53	No	No	0	9	9
15	R:R:F289	R:R:S202	79.6744	3.96	Yes	No	0	7	6
16	R:R:S202	R:R:T108	78.677	9.59	No	No	0	6	6
17	R:R:S151	R:R:T108	76.7287	4.8	No	No	0	8	6
18	R:R:A109	R:R:S151	75.7003	3.42	No	No	0	7	8
19	R:R:A109	R:R:W148	74.6615	7.78	No	No	0	7	9
20	R:R:S65	R:R:W148	73.6124	4.94	No	No	0	9	9
21	R:R:I144	R:R:S65	71.4832	6.19	No	No	0	8	9
22	R:R:F62	R:R:I144	70.4031	5.02	Yes	No	0	8	8
23	R:R:D120	R:R:F62	67.1008	10.75	Yes	Yes	0	9	8
24	R:R:D120	R:R:T59	29.8398	5.78	Yes	No	3	9	8
25	R:R:N60	R:R:T59	30.4858	4.39	No	No	0	9	8
26	R:R:F337	R:R:N60	26.1757	6.04	Yes	No	0	9	9
27	R:R:D336	R:R:F337	15.7054	4.78	Yes	Yes	2	7	9
28	R:R:D336	R:R:H53	12.646	3.78	Yes	No	2	7	6
29	R:R:F51	R:R:H53	11.137	6.79	Yes	No	0	6	6
30	R:R:D120	R:R:M135	24.3411	4.16	Yes	Yes	3	9	7
31	R:R:M135	R:R:V58	13.1835	4.56	Yes	No	0	7	6
32	R:R:P137	R:R:V58	11.5711	5.3	No	No	0	1	6
33	R:R:D120	R:R:Y131	13.7416	9.2	Yes	Yes	3	9	7
34	R:R:F281	R:R:W285	74.3101	6.01	Yes	Yes	1	9	8
35	R:R:F281	R:R:L114	73.1835	3.65	Yes	No	1	9	9
36	R:R:L114	R:R:Y331	66.7028	7.03	No	Yes	1	9	9
37	R:R:F95	R:R:W99	19.8656	5.01	No	Yes	1	5	5
38	R:R:F95	R:R:I98	18.8682	3.77	No	No	0	5	6
39	R:R:I98	R:R:Q160	17.4367	4.12	No	No	0	6	5
40	R:R:F156	R:R:Q160	33.6951	8.2	Yes	No	0	5	5
41	R:R:F102	R:R:F156	31.2506	6.43	No	Yes	0	5	5
42	R:R:F102	R:R:L76	26.0672	6.09	No	No	0	5	6
43	R:R:L72	R:R:L76	15.6693	4.15	No	No	0	7	6
44	R:R:W321	R:R:W99	11.2093	3.75	Yes	Yes	1	7	5
45	R:R:W80	R:R:W99	11.5349	5.62	No	Yes	1	5	5
46	R:R:F92	R:R:W80	10.4496	8.02	No	No	0	6	5
47	R:R:W90	R:R:W99	22.1189	4.69	Yes	Yes	1	8	5
48	R:R:F92	R:R:W90	10.1085	15.03	No	Yes	0	6	8
49	R:R:F92	R:R:P91	17.1008	8.67	No	No	0	6	1
50	R:R:F89	R:R:P91	10.2894	5.78	No	No	0	4	1
51	R:R:A101	R:R:V159	20.6202	5.09	No	Yes	0	6	5
52	R:R:H164	R:R:V159	44.7855	12.45	Yes	Yes	0	5	5
53	R:R:H164	R:R:L190	51.7726	3.86	Yes	Yes	0	5	4
54	L:L:?1	R:R:L190	42.9974	7.82	Yes	Yes	1	0	4
55	L:L:?1	R:R:I104	18.77	13.1	Yes	No	0	0	6
56	R:R:I104	R:R:Y194	17.3333	4.84	No	Yes	0	6	7
57	L:L:?1	R:R:S198	18.8941	5.3	Yes	No	0	0	7
58	R:R:S198	R:R:Y194	17.4574	10.17	No	Yes	0	7	7
59	R:R:F156	R:R:M105	10.4444	7.46	Yes	No	4	5	5
60	R:R:I111	R:R:W285	20.0827	7.05	No	Yes	1	8	8
61	R:R:I111	R:R:P206	21.3902	3.39	No	Yes	0	8	9
62	R:R:R121	R:R:Y331	63.9018	6.17	No	Yes	1	9	9
63	R:R:R121	R:R:Y214	62.2894	4.12	No	Yes	0	9	9
64	R:R:S118	R:R:Y214	20.6667	5.09	No	Yes	0	8	9
65	R:R:S118	R:R:T213	16.615	4.8	No	No	0	8	7
66	R:R:T213	R:R:Y122	12.522	6.24	No	Yes	0	7	8
67	R:R:W123	R:R:Y131	11.9432	7.72	Yes	Yes	3	4	7
68	R:R:M135	R:R:W123	11.3643	4.65	Yes	Yes	3	7	4
69	R:R:K134	R:R:W123	11.7364	4.64	No	Yes	0	5	4
70	R:R:P158	R:R:Y194	22.0724	5.56	No	Yes	0	6	7
71	R:R:I157	R:R:P158	11.0801	5.08	No	No	0	6	6
72	R:R:F203	R:R:F289	18.0207	21.43	Yes	Yes	1	8	7
73	R:R:F203	R:R:L286	23.0749	3.65	Yes	Yes	0	8	6
74	R:R:L274	R:R:Y214	28.4289	3.52	No	Yes	0	8	9
75	R:R:I277	R:R:Y214	10.4599	6.04	No	Yes	0	8	9
76	R:R:L274	R:R:Y218	26.4496	3.52	No	Yes	0	8	7
77	R:R:V270	R:R:Y218	14.4651	3.79	No	Yes	0	8	7
78	R:R:I225	R:R:V270	10.3411	1.54	No	No	0	5	8
79	R:R:L286	R:R:P287	15.0646	3.28	Yes	No	0	6	9
80	R:R:F316	R:R:P287	13.4315	10.11	No	No	0	5	9
81	R:R:L33	R:R:S325	20.2429	3	No	Yes	0	7	6
82	R:R:S325	R:R:T37	10.1654	3.2	Yes	No	0	6	7
83	R:R:L112	R:R:P206	10.77	3.28	No	Yes	0	5	9
84	R:R:S191	R:R:Y194	11.0801	1.27	No	Yes	0	5	7
85	R:R:M78	R:R:W321	26.5943	3.49	Yes	Yes	1	7	7
86	L:L:?1	R:R:W99	55.3437	7.24	Yes	Yes	1	0	5
87	R:R:A101	R:R:F156	18.5013	5.55	No	Yes	0	6	5
88	R:R:Q160	R:R:V159	20.6977	5.73	No	Yes	0	5	5
89	R:R:F288	R:R:N292	14.3979	4.83	Yes	Yes	1	7	6
90	R:R:L190	R:R:N292	14.615	4.12	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W99	4.9	1	No	Yes	8	5	2	1
R:R:D103	R:R:V77	4.38	1	Yes	No	7	8	1	2
R:R:V77	R:R:W321	6.13	1	No	Yes	8	7	2	2
R:R:F95	R:R:W80	5.01	1	No	No	5	5	2	2
R:R:W80	R:R:W99	5.62	1	No	Yes	5	5	2	1
R:R:E85	R:R:K81	5.4	1	No	Yes	4	6	2	1
R:R:K81	R:R:W99	9.28	1	Yes	Yes	6	5	1	1
R:R:D314	R:R:K81	8.3	1	No	Yes	4	6	2	1
R:R:K81	R:R:W318	6.96	1	Yes	Yes	6	5	1	2
R:R:K81	R:R:W321	4.64	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:K81	3.98	1	Yes	Yes	0	6	0	1
R:R:D314	R:R:E85	7.8	1	No	No	4	4	2	2
R:R:W90	R:R:W99	4.69	1	Yes	Yes	8	5	2	1
R:R:F95	R:R:W99	5.01	1	No	Yes	5	5	2	1
R:R:W321	R:R:W99	3.75	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:W99	7.24	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V100	6.31	1	Yes	No	0	5	0	1
R:R:D103	R:R:S107	4.42	1	Yes	No	7	7	1	2
R:R:D103	R:R:W321	12.28	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D103	9.58	1	Yes	Yes	0	7	0	1
R:R:I104	R:R:Y194	4.84	0	No	Yes	6	7	1	2
L:L:?1	R:R:I104	13.1	1	Yes	No	0	6	0	1
R:R:S107	R:R:W285	4.94	0	No	Yes	7	8	2	2
R:R:H164	R:R:L190	3.86	0	Yes	Yes	5	4	2	1
R:R:H164	R:R:Y194	6.53	0	Yes	Yes	5	7	2	2
R:R:L190	R:R:N292	4.12	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:L190	7.82	1	Yes	Yes	0	4	0	1
R:R:S198	R:R:Y194	10.17	0	No	Yes	7	7	1	2
L:L:?1	R:R:S198	5.3	1	Yes	No	0	7	0	1
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:N292	R:R:S199	5.96	1	Yes	No	6	7	1	2
R:R:F289	R:R:S202	3.96	1	Yes	No	7	6	1	2
R:R:F203	R:R:W285	4.01	1	Yes	Yes	8	8	2	2
R:R:F203	R:R:F289	21.43	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	11.79	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	4.83	1	Yes	Yes	7	6	1	1
R:R:F288	R:R:F313	5.36	1	Yes	Yes	7	4	1	2
L:L:?1	R:R:F288	12.04	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.16	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	7.75	1	Yes	Yes	0	6	0	1
R:R:W318	R:R:W321	10.31	1	Yes	Yes	5	7	2	2
R:R:A195	R:R:L190	3.15	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9I52_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	253
Number of Links	280
Number of Hubs	37
Number of Links mediated by Hubs	146
Number of Communities	5
Number of Nodes involved in Communities	48
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	51994
Length Of Smallest Path	3
Average Path Length	13.3623
Length of Longest Path	30
Minimum Path Strength	1.42
Average Path Strength	5.93487
Maximum Path Strength	16.61
Minimum Path Correlation	0.7
Average Path Correlation	0.94061
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	55.6652
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3973
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • dopamine binding • G-protein alpha-subunit binding • heterotrimeric G-protein binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • response to xenobiotic stimulus • behavior • learning • learning or memory • feeding behavior • cognition • associative learning • conditioned taste aversion • D-glucose import • hexose transmembrane transport • carbohydrate transport • transmembrane transport • D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • presynaptic modulation of chemical synaptic transmission • regulation of amine metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • memory • establishment of protein localization • nitrogen compound transport • nucleocytoplasmic transport • nuclear transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • system development • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • startle response • regulation of response to external stimulus • neuromuscular process • prepulse inhibition • response to external stimulus • negative regulation of response to external stimulus • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • adenylate cyclase-activating dopamine receptor signaling pathway • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • phasic smooth muscle contraction • peristalsis • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • catecholamine uptake • dopamine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • action potential • neuronal action potential • dentate gyrus development • pallium development • hippocampus development • limbic system development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • maintenance of location • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • inorganic ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • multicellular organismal response to stress • negative regulation of synaptic transmission • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • postsynapse • postsynaptic membrane • synapse • cell junction • synaptic membrane • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • neuron projection • dendritic spine • somatodendritic compartment • dendrite • dendritic tree • non-motile cilium • GABA-ergic synapse • ciliary membrane • cell projection membrane • organelle subcompartment • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • G-protein beta-subunit binding • fibroblast proliferation • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1I
Name	N-(cyclopent-3-ene-1-carbonyl)-L-histidine
Synonyms
Identifier
Formula	C12 H15 N3 O3
Molecular Weight	249.266
SMILES
PubChem	64766902
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	1
Total Bonds	34
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>9I52_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K P N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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