psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A82	R:R:L30	4.73	No	No	0	6	7
2	R:R:L30	R:R:W318	6.83	No	Yes	0	7	5
3	R:R:L33	R:R:M78	4.24	No	Yes	0	7	7
4	R:R:I34	R:R:M78	4.37	No	Yes	0	6	7
5	R:R:D70	R:R:N41	13.46	Yes	No	0	9	9
6	R:R:N41	R:R:P328	6.52	No	No	0	9	9
7	R:R:P328	R:R:V44	3.53	No	No	0	9	9
8	R:R:F341	R:R:V44	5.24	No	No	0	7	9
9	R:R:I64	R:R:V48	4.61	No	No	0	6	8
10	R:R:L344	R:R:R50	3.64	No	No	0	6	6
11	R:R:F51	R:R:H53	6.79	Yes	No	0	6	6
12	R:R:A340	R:R:F51	5.55	No	Yes	0	7	6
13	R:R:F51	R:R:T343	5.19	Yes	No	0	6	4
14	R:R:H53	R:R:L54	9	No	No	2	6	9
15	R:R:D336	R:R:H53	3.78	Yes	No	2	7	6
16	R:R:D336	R:R:L54	5.43	Yes	No	2	7	9
17	R:R:K57	R:R:N60	5.6	No	No	0	5	9
18	R:R:M135	R:R:V58	4.56	Yes	No	0	7	6
19	R:R:P137	R:R:V58	5.3	No	No	0	1	6
20	R:R:N60	R:R:T59	4.39	No	No	0	9	8
21	R:R:D120	R:R:T59	5.78	Yes	No	3	9	8
22	R:R:T59	R:R:Y131	4.99	No	Yes	3	8	7
23	R:R:F337	R:R:N60	6.04	Yes	No	0	9	9
24	R:R:A140	R:R:F61	4.16	No	No	0	7	4
25	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
26	R:R:D120	R:R:F62	10.75	Yes	Yes	0	9	8
27	R:R:F62	R:R:L143	3.65	Yes	No	0	8	7
28	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
29	R:R:N113	R:R:S65	8.94	No	No	0	8	9
30	R:R:I144	R:R:S65	6.19	No	No	0	8	9
31	R:R:S65	R:R:W148	4.94	No	No	0	9	9
32	R:R:L66	R:R:S69	4.5	Yes	No	1	9	8
33	R:R:D70	R:R:L66	8.14	Yes	Yes	1	9	9
34	R:R:L114	R:R:L66	5.54	No	Yes	1	9	9
35	R:R:L66	R:R:N327	6.87	Yes	No	1	9	9
36	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
37	R:R:D70	R:R:S69	4.42	Yes	No	1	9	8
38	R:R:S110	R:R:S69	4.89	No	No	1	9	8
39	R:R:D70	R:R:S110	4.42	Yes	No	1	9	9
40	R:R:D70	R:R:S324	11.78	Yes	No	0	9	9
41	R:R:D70	R:R:N327	9.42	Yes	No	1	9	9
42	R:R:L72	R:R:L76	4.15	No	No	0	7	6
43	R:R:S324	R:R:V73	4.85	No	No	0	9	8
44	R:R:F102	R:R:L76	6.09	No	No	0	5	6
45	R:R:V77	R:R:W99	4.9	No	Yes	1	8	5
46	R:R:D103	R:R:V77	4.38	Yes	No	1	7	8
47	R:R:V77	R:R:W321	6.13	No	Yes	1	8	7
48	R:R:M78	R:R:W318	5.82	Yes	Yes	1	7	5
49	R:R:M78	R:R:W321	3.49	Yes	Yes	1	7	7
50	R:R:F92	R:R:W80	8.02	No	No	0	6	5
51	R:R:F95	R:R:W80	5.01	No	No	1	5	5
52	R:R:W80	R:R:W99	5.62	No	Yes	1	5	5
53	R:R:E85	R:R:K81	5.4	No	Yes	1	4	6
54	R:R:K81	R:R:W99	9.28	Yes	Yes	1	6	5
55	R:R:D314	R:R:K81	8.3	No	Yes	1	4	6
56	R:R:K81	R:R:W318	6.96	Yes	Yes	1	6	5
57	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
58	L:L:?1	R:R:K81	4.27	Yes	Yes	1	0	6
59	R:R:D314	R:R:E85	7.8	No	No	1	4	4
60	R:R:F89	R:R:P91	5.78	No	No	0	4	1
61	R:R:F92	R:R:W90	15.03	No	Yes	0	6	8
62	R:R:C96	R:R:W90	5.22	No	Yes	1	9	8
63	R:R:W90	R:R:W99	4.69	Yes	Yes	1	8	5
64	R:R:C186	R:R:W90	10.45	No	Yes	1	9	8
65	R:R:F92	R:R:P91	8.67	No	No	0	6	1
66	R:R:F95	R:R:I98	3.77	No	No	0	5	6
67	R:R:F95	R:R:W99	5.01	No	Yes	1	5	5
68	R:R:C186	R:R:C96	7.28	No	No	1	9	9
69	R:R:I98	R:R:Q160	4.12	No	No	0	6	5
70	R:R:W321	R:R:W99	3.75	Yes	Yes	1	7	5
71	L:L:?1	R:R:W99	7.76	Yes	Yes	1	0	5
72	L:L:?1	R:R:V100	6.77	Yes	No	0	0	5
73	R:R:A101	R:R:F156	5.55	No	Yes	0	6	5
74	R:R:A101	R:R:V159	5.09	No	Yes	0	6	5
75	R:R:F102	R:R:F156	6.43	No	Yes	0	5	5
76	R:R:D103	R:R:S107	4.42	Yes	No	0	7	7
77	R:R:D103	R:R:W321	12.28	Yes	Yes	1	7	7
78	L:L:?1	R:R:D103	10.28	Yes	Yes	1	0	7
79	R:R:I104	R:R:Y194	4.84	No	Yes	0	6	7
80	L:L:?1	R:R:I104	14.05	Yes	No	0	0	6
81	R:R:M105	R:R:S155	6.13	No	No	4	5	7
82	R:R:F156	R:R:M105	7.46	Yes	No	4	5	5
83	R:R:S107	R:R:W285	4.94	No	Yes	0	7	8
84	R:R:S151	R:R:T108	4.8	No	No	0	8	6
85	R:R:I154	R:R:T108	4.56	No	No	0	5	6
86	R:R:S202	R:R:T108	9.59	No	No	0	6	6
87	R:R:A109	R:R:W148	7.78	No	No	0	7	9
88	R:R:A109	R:R:S151	3.42	No	No	0	7	8
89	R:R:F281	R:R:I111	5.02	Yes	No	1	9	8
90	R:R:I111	R:R:W285	7.05	No	Yes	1	8	8
91	R:R:F281	R:R:L114	3.65	Yes	No	1	9	9
92	R:R:L114	R:R:Y331	7.03	No	Yes	1	9	9
93	R:R:C115	R:R:P206	3.77	No	Yes	0	7	9
94	R:R:C115	R:R:I209	6.55	No	No	0	7	6
95	R:R:I117	R:R:R121	3.76	No	No	1	9	9
96	R:R:I117	R:R:Y331	3.63	No	Yes	1	9	9
97	R:R:S118	R:R:T213	4.8	No	No	0	8	7
98	R:R:S118	R:R:Y214	5.09	No	Yes	0	8	9
99	R:R:D120	R:R:Y131	9.2	Yes	Yes	3	9	7
100	R:R:D120	R:R:M135	4.16	Yes	Yes	3	9	7
101	R:R:R121	R:R:Y214	4.12	No	Yes	0	9	9
102	R:R:R121	R:R:Y331	6.17	No	Yes	1	9	9
103	R:R:S126	R:R:Y122	8.9	No	Yes	0	7	8
104	R:R:T213	R:R:Y122	6.24	No	Yes	0	7	8
105	R:R:R216	R:R:Y122	11.32	No	Yes	0	5	8
106	R:R:I217	R:R:Y122	3.63	No	Yes	0	9	8
107	R:R:S127	R:R:W123	4.94	No	Yes	0	6	4
108	R:R:W123	R:R:Y131	7.72	Yes	Yes	3	4	7
109	R:R:K134	R:R:W123	4.64	No	Yes	0	5	4
110	R:R:M135	R:R:W123	4.65	Yes	Yes	3	7	4
111	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
112	R:R:I125	R:R:I217	4.42	No	No	0	8	9
113	R:R:R130	R:R:S127	3.95	No	No	0	5	6
114	R:R:E132	R:R:F129	3.5	No	No	0	5	7
115	R:R:M135	R:R:Y131	15.57	Yes	Yes	3	7	7
116	R:R:K134	R:R:R133	7.43	No	No	0	5	4
117	R:R:P137	R:R:T136	3.5	No	No	0	1	8
118	R:R:K138	R:R:T136	6.01	No	No	0	4	8
119	R:R:F156	R:R:S155	6.61	Yes	No	4	5	7
120	R:R:F156	R:R:Q160	8.2	Yes	No	0	5	5
121	R:R:I157	R:R:P158	5.08	No	No	0	6	6
122	R:R:P158	R:R:Y194	5.56	No	Yes	0	6	7
123	R:R:Q160	R:R:V159	5.73	No	Yes	0	5	5
124	R:R:H164	R:R:V159	12.45	Yes	Yes	0	5	5
125	R:R:L161	R:R:W163	13.67	No	No	0	4	6
126	R:R:H164	R:R:K165	18.34	Yes	No	0	5	3
127	R:R:H164	R:R:L190	3.86	Yes	Yes	0	5	4
128	R:R:H164	R:R:Y194	6.53	Yes	Yes	0	5	7
129	R:R:K165	R:R:S188	4.59	No	No	0	3	5
130	R:R:A166	R:R:P168	3.74	No	No	0	2	1
131	R:R:D187	R:R:N185	4.04	No	No	0	5	4
132	R:R:L190	R:R:N292	4.12	Yes	Yes	1	4	6
133	L:L:?1	R:R:L190	8.38	Yes	Yes	1	0	4
134	R:R:F297	R:R:R192	18.17	No	No	0	6	4
135	R:R:S198	R:R:Y194	10.17	No	Yes	0	7	7
136	R:R:A195	R:R:P296	3.74	No	No	0	5	5
137	L:L:?1	R:R:S198	5.68	Yes	No	0	0	7
138	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
139	R:R:N292	R:R:S199	5.96	Yes	No	0	6	7
140	R:R:C293	R:R:S199	3.44	No	No	0	6	7
141	R:R:F289	R:R:S202	3.96	Yes	No	0	7	6
142	R:R:F203	R:R:Y204	6.19	Yes	No	0	8	5
143	R:R:F203	R:R:W285	4.01	Yes	Yes	1	8	8
144	R:R:F203	R:R:L286	3.65	Yes	Yes	0	8	6
145	R:R:F203	R:R:F289	21.43	Yes	Yes	1	8	7
146	R:R:F281	R:R:M210	7.46	Yes	No	0	9	8
147	R:R:L274	R:R:Y214	3.52	No	Yes	0	8	9
148	R:R:I277	R:R:Y214	6.04	No	Yes	0	8	9
149	R:R:M278	R:R:Y214	3.59	No	Yes	0	8	9
150	R:R:R219	R:R:Y218	8.23	No	Yes	5	4	7
151	R:R:Q222	R:R:Y218	5.64	No	Yes	5	6	7
152	R:R:V270	R:R:Y218	3.79	No	Yes	0	8	7
153	R:R:L271	R:R:Y218	9.38	No	Yes	0	7	7
154	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
155	R:R:Q222	R:R:R219	8.18	No	No	5	6	4
156	R:R:Q222	R:R:R226	3.5	No	No	0	6	5
157	R:R:K223	R:R:R226	3.71	No	No	0	5	5
158	R:R:Q224	R:R:R227	10.51	No	No	0	7	5
159	R:R:I225	R:R:R266	3.76	No	No	0	5	6
160	R:R:E267	R:R:I225	4.1	No	No	0	8	5
161	R:R:I228	R:R:R266	5.01	No	No	0	7	6
162	R:R:F264	R:R:T268	7.78	No	No	0	5	5
163	R:R:I330	R:R:V280	4.61	No	No	0	8	7
164	R:R:F281	R:R:W285	6.01	Yes	Yes	1	9	8
165	R:R:C284	R:R:N323	9.45	No	No	0	9	9
166	R:R:F288	R:R:W285	7.02	Yes	Yes	1	7	8
167	R:R:F289	R:R:W285	5.01	Yes	Yes	1	7	8
168	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
169	R:R:N323	R:R:W285	6.78	No	Yes	0	9	8
170	R:R:I290	R:R:L286	7.14	No	Yes	0	7	6
171	R:R:F316	R:R:P287	10.11	No	No	0	5	9
172	R:R:F288	R:R:F289	11.79	Yes	Yes	1	7	7
173	R:R:F288	R:R:N292	4.83	Yes	Yes	1	7	6
174	R:R:F288	R:R:F313	5.36	Yes	Yes	0	7	4
175	L:L:?1	R:R:F288	12.91	Yes	Yes	1	0	7
176	L:L:?1	R:R:F289	5.53	Yes	Yes	1	0	7
177	R:R:F313	R:R:L291	3.65	Yes	No	0	4	5
178	L:L:?1	R:R:N292	8.32	Yes	Yes	1	0	6
179	R:R:F313	R:R:L295	7.31	Yes	No	0	4	3
180	R:R:I308	R:R:T312	4.56	No	No	0	4	4
181	R:R:D309	R:R:T312	4.34	No	No	0	4	4
182	R:R:F316	R:R:T312	3.89	No	No	0	5	4
183	R:R:F313	R:R:V317	3.93	Yes	No	0	4	6
184	R:R:F319	R:R:V315	3.93	No	No	0	7	4
185	R:R:F316	R:R:F319	4.29	No	No	0	5	7
186	R:R:V317	R:R:W321	7.36	No	Yes	0	6	7
187	R:R:W318	R:R:W321	10.31	Yes	Yes	1	5	7
188	R:R:N323	R:R:N327	6.81	No	No	0	9	9
189	R:R:L326	R:R:S325	4.5	No	Yes	0	6	6
190	R:R:I330	R:R:Y331	8.46	No	Yes	0	8	9
191	R:R:A332	R:R:F337	5.55	No	Yes	0	6	9
192	R:R:F333	R:R:R338	12.83	No	No	0	8	8
193	R:R:D336	R:R:N334	10.77	Yes	No	2	7	8
194	R:R:F337	R:R:N334	9.67	Yes	No	2	9	8
195	R:R:D336	R:R:F337	4.78	Yes	Yes	2	7	9
196	R:R:G346	R:R:Y348	5.79	No	No	0	5	3
197	R:R:A67	R:R:V44	3.39	No	No	0	9	9
198	R:R:I111	R:R:P206	3.39	No	Yes	0	8	9
199	R:R:I205	R:R:P206	3.39	No	Yes	0	5	9
200	R:R:A74	R:R:T37	3.36	No	No	0	7	7
201	R:R:L112	R:R:P206	3.28	No	Yes	0	5	9
202	R:R:L286	R:R:P287	3.28	Yes	No	0	6	9
203	R:R:C293	R:R:I196	3.27	No	No	0	6	6
204	R:R:A27	R:R:I86	3.25	No	No	0	6	5
205	R:R:F141	R:R:F61	3.22	No	No	0	3	4
206	R:R:S325	R:R:T37	3.2	Yes	No	0	6	7
207	R:R:C106	R:R:L72	3.17	No	No	0	7	7
208	R:R:A74	R:R:L38	3.15	No	No	0	7	7
209	R:R:A147	R:R:L112	3.15	No	No	0	7	5
210	R:R:A195	R:R:L190	3.15	No	Yes	0	5	4
211	R:R:I205	R:R:V200	3.07	No	No	0	5	4
212	R:R:K57	R:R:S56	3.06	No	No	0	5	8
213	R:R:K165	R:R:S162	3.06	No	No	0	3	5
214	R:R:L33	R:R:S325	3	No	Yes	0	7	6
215	R:R:L76	R:R:V75	2.98	No	No	0	6	5
216	R:R:L286	R:R:V282	2.98	Yes	No	0	6	7
217	R:R:N97	R:R:V159	2.96	No	Yes	0	6	5
218	R:R:L153	R:R:T149	2.95	No	No	0	4	3
219	R:R:I125	R:R:I220	2.94	No	No	0	8	6
220	R:R:F61	R:R:P137	2.89	No	No	0	4	1
221	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
222	R:R:A47	R:R:F341	2.77	No	No	0	8	7
223	R:R:A87	R:R:F89	2.77	No	No	0	5	4
224	R:R:L112	R:R:L150	2.77	No	No	0	5	4
225	R:R:L71	R:R:N41	2.75	No	No	0	8	9
226	R:R:P158	R:R:W163	2.7	No	No	0	6	6
227	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
228	R:R:F281	R:R:V207	2.62	Yes	No	0	9	7
229	R:R:A84	R:R:W90	2.59	No	Yes	0	5	8
230	R:R:F297	R:R:I196	2.51	No	No	0	6	6
231	R:R:F341	R:R:L43	2.44	No	No	0	7	7
232	R:R:F51	R:R:L344	2.44	Yes	No	0	6	6
233	R:R:E232	R:R:R266	2.33	No	No	0	3	6
234	R:R:N185	R:R:W90	2.26	No	Yes	0	4	8
235	R:R:G40	R:R:P328	2.03	No	No	0	9	9
236	R:R:C347	R:R:G346	1.96	No	No	0	9	5
237	R:R:A87	R:R:G88	1.95	No	No	0	5	4
238	R:R:G279	R:R:V282	1.84	No	No	0	5	7
239	R:R:C283	R:R:C284	1.82	No	No	0	5	9
240	R:R:A67	R:R:C45	1.81	No	No	0	9	7
241	R:R:P128	R:R:S127	1.78	No	No	0	8	6
242	R:R:P91	R:R:V83	1.77	No	No	0	1	4
243	R:R:G40	R:R:L39	1.71	No	No	0	9	4
244	R:R:A322	R:R:S325	1.71	No	Yes	0	4	6
245	R:R:A332	R:R:V63	1.7	No	No	0	6	8
246	R:R:A221	R:R:V270	1.7	No	No	0	9	8
247	R:R:M78	R:R:P79	1.68	Yes	No	0	7	8
248	R:R:A139	R:R:T136	1.68	No	No	0	6	8
249	R:R:K167	R:R:P168	1.67	No	No	0	2	1
250	R:R:C28	R:R:I24	1.64	No	No	0	5	6
251	R:R:S118	R:R:V119	1.62	No	No	0	8	6
252	R:R:S275	R:R:V276	1.62	No	No	0	6	7
253	R:R:S191	R:R:T193	1.6	No	No	0	5	4
254	R:R:S197	R:R:T193	1.6	No	No	0	4	4
255	R:R:T26	R:R:V22	1.59	No	No	0	5	4
256	R:R:T213	R:R:V212	1.59	No	No	0	7	4
257	R:R:A46	R:R:L344	1.58	No	No	0	5	6
258	R:R:I24	R:R:S21	1.55	No	No	0	6	4
259	R:R:I142	R:R:V146	1.54	No	No	0	1	3
260	R:R:I225	R:R:V270	1.54	No	No	0	5	8
261	R:R:M105	R:R:V152	1.52	No	No	0	5	4
262	R:R:K272	R:R:V276	1.52	No	No	0	7	7
263	R:R:I277	R:R:T273	1.52	No	No	0	8	9
264	R:R:K272	R:R:T273	1.5	No	No	0	7	9
265	R:R:K339	R:R:T343	1.5	No	No	0	5	4
266	R:R:L72	R:R:V68	1.49	No	No	0	7	6
267	R:R:L150	R:R:V146	1.49	No	No	0	4	3
268	R:R:N311	R:R:S310	1.49	No	No	0	1	1
269	R:R:N240	R:R:V236	1.48	No	No	0	4	4
270	R:R:L30	R:R:T26	1.47	No	No	0	7	5
271	R:R:L71	R:R:T42	1.47	No	No	0	8	5
272	R:R:I290	R:R:I294	1.47	No	No	0	7	5
273	R:R:I211	R:R:M278	1.46	No	No	0	6	8
274	R:R:I157	R:R:L153	1.43	No	No	0	6	4
275	R:R:A230	R:R:R233	1.38	No	No	0	4	1
276	R:R:D309	R:R:N311	1.35	No	No	0	4	1
277	R:R:F264	R:R:S263	1.32	No	No	0	5	5
278	R:R:R55	R:R:V48	1.31	No	No	0	8	8
279	R:R:S191	R:R:Y194	1.27	No	Yes	0	5	7
280	R:R:E132	R:R:R133	1.16	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	4.9925	4	0	6
2	R:R:F62	6.165	4	0	8
3	R:R:L66	5.714	5	1	9
4	R:R:D70	8.60667	6	1	9
5	R:R:M78	3.92	5	1	7
6	R:R:K81	6.475	6	1	6
7	R:R:W90	6.15	7	1	8
8	R:R:W99	5.85857	7	1	5
9	R:R:D103	7.84	4	1	7
10	R:R:D120	7.4725	4	3	9
11	R:R:Y122	7.5225	4	0	8
12	R:R:W123	5.4875	4	3	4
13	R:R:Y131	9.098	5	3	7
14	R:R:M135	7.235	4	3	7
15	R:R:F156	6.85	5	4	5
16	R:R:V159	6.5575	4	0	5
17	R:R:H164	10.295	4	0	5
18	R:R:L190	4.8775	4	1	4
19	R:R:Y194	5.674	5	0	7
20	R:R:F203	8.82	4	1	8
21	R:R:P206	3.4575	4	0	9
22	R:R:Y214	4.472	5	0	9
23	R:R:Y218	6.112	5	5	7
24	R:R:F281	4.952	5	1	9
25	R:R:W285	6.1575	8	1	8
26	R:R:L286	4.2625	4	0	6
27	R:R:F288	8.382	5	1	7
28	R:R:F289	8.83333	6	1	7
29	R:R:N292	5.8075	4	1	6
30	R:R:F313	5.0625	4	0	4
31	R:R:W318	7.48	4	1	5
32	R:R:W321	6.85143	7	1	7
33	R:R:S325	3.1025	4	0	6
34	R:R:Y331	5.762	5	1	9
35	R:R:D336	6.19	4	2	7
36	R:R:F337	5.732	5	2	9
37	L:L:?1	8.395	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L33	R:R:M78	23.5814	4.24	No	Yes	0	7	7
2	R:R:K81	R:R:W318	14.6408	6.96	Yes	Yes	1	6	5
3	L:L:?1	R:R:K81	24.9974	4.27	Yes	Yes	1	0	6
4	L:L:?1	R:R:F288	41.7571	12.91	Yes	Yes	1	0	7
5	R:R:F288	R:R:W285	55.1008	7.02	Yes	Yes	1	7	8
6	R:R:N323	R:R:W285	41.0284	6.78	No	Yes	0	9	8
7	R:R:N323	R:R:N327	36.5013	6.81	No	No	0	9	9
8	R:R:D70	R:R:N327	30.6873	9.42	Yes	No	1	9	9
9	L:L:?1	R:R:F289	100	5.53	Yes	Yes	1	0	7
10	R:R:F289	R:R:W285	67.1783	5.01	Yes	Yes	1	7	8
11	R:R:D103	R:R:W321	15.0801	12.28	Yes	Yes	1	7	7
12	R:R:D70	R:R:N41	25.2972	13.46	Yes	No	0	9	9
13	R:R:N41	R:R:P328	19.1111	6.52	No	No	0	9	9
14	R:R:P328	R:R:V44	12.832	3.53	No	No	0	9	9
15	R:R:F289	R:R:S202	79.6744	3.96	Yes	No	0	7	6
16	R:R:S202	R:R:T108	78.677	9.59	No	No	0	6	6
17	R:R:S151	R:R:T108	76.7287	4.8	No	No	0	8	6
18	R:R:A109	R:R:S151	75.7003	3.42	No	No	0	7	8
19	R:R:A109	R:R:W148	74.6615	7.78	No	No	0	7	9
20	R:R:S65	R:R:W148	73.6124	4.94	No	No	0	9	9
21	R:R:I144	R:R:S65	71.4832	6.19	No	No	0	8	9
22	R:R:F62	R:R:I144	70.4031	5.02	Yes	No	0	8	8
23	R:R:D120	R:R:F62	67.1008	10.75	Yes	Yes	0	9	8
24	R:R:D120	R:R:T59	29.8398	5.78	Yes	No	3	9	8
25	R:R:N60	R:R:T59	30.4858	4.39	No	No	0	9	8
26	R:R:F337	R:R:N60	26.1757	6.04	Yes	No	0	9	9
27	R:R:D336	R:R:F337	15.7054	4.78	Yes	Yes	2	7	9
28	R:R:D336	R:R:H53	12.646	3.78	Yes	No	2	7	6
29	R:R:F51	R:R:H53	11.137	6.79	Yes	No	0	6	6
30	R:R:D120	R:R:M135	24.3411	4.16	Yes	Yes	3	9	7
31	R:R:M135	R:R:V58	13.1835	4.56	Yes	No	0	7	6
32	R:R:P137	R:R:V58	11.5711	5.3	No	No	0	1	6
33	R:R:D120	R:R:Y131	13.7416	9.2	Yes	Yes	3	9	7
34	R:R:F281	R:R:W285	74.3101	6.01	Yes	Yes	1	9	8
35	R:R:F281	R:R:L114	73.1835	3.65	Yes	No	1	9	9
36	R:R:L114	R:R:Y331	66.7028	7.03	No	Yes	1	9	9
37	R:R:F95	R:R:W99	19.8656	5.01	No	Yes	1	5	5
38	R:R:F95	R:R:I98	18.8682	3.77	No	No	0	5	6
39	R:R:I98	R:R:Q160	17.4367	4.12	No	No	0	6	5
40	R:R:F156	R:R:Q160	33.6951	8.2	Yes	No	0	5	5
41	R:R:F102	R:R:F156	31.2506	6.43	No	Yes	0	5	5
42	R:R:F102	R:R:L76	26.0672	6.09	No	No	0	5	6
43	R:R:L72	R:R:L76	15.6693	4.15	No	No	0	7	6
44	R:R:W321	R:R:W99	11.2093	3.75	Yes	Yes	1	7	5
45	R:R:W80	R:R:W99	11.5349	5.62	No	Yes	1	5	5
46	R:R:F92	R:R:W80	10.4496	8.02	No	No	0	6	5
47	R:R:W90	R:R:W99	22.1189	4.69	Yes	Yes	1	8	5
48	R:R:F92	R:R:W90	10.1085	15.03	No	Yes	0	6	8
49	R:R:F92	R:R:P91	17.1008	8.67	No	No	0	6	1
50	R:R:F89	R:R:P91	10.2894	5.78	No	No	0	4	1
51	R:R:A101	R:R:V159	20.6202	5.09	No	Yes	0	6	5
52	R:R:H164	R:R:V159	44.7855	12.45	Yes	Yes	0	5	5
53	R:R:H164	R:R:L190	51.7726	3.86	Yes	Yes	0	5	4
54	L:L:?1	R:R:L190	42.9974	8.38	Yes	Yes	1	0	4
55	L:L:?1	R:R:I104	18.77	14.05	Yes	No	0	0	6
56	R:R:I104	R:R:Y194	17.3333	4.84	No	Yes	0	6	7
57	L:L:?1	R:R:S198	18.8941	5.68	Yes	No	0	0	7
58	R:R:S198	R:R:Y194	17.4574	10.17	No	Yes	0	7	7
59	R:R:F156	R:R:M105	10.4444	7.46	Yes	No	4	5	5
60	R:R:I111	R:R:W285	20.0827	7.05	No	Yes	1	8	8
61	R:R:I111	R:R:P206	21.3902	3.39	No	Yes	0	8	9
62	R:R:R121	R:R:Y331	63.9018	6.17	No	Yes	1	9	9
63	R:R:R121	R:R:Y214	62.2894	4.12	No	Yes	0	9	9
64	R:R:S118	R:R:Y214	20.6667	5.09	No	Yes	0	8	9
65	R:R:S118	R:R:T213	16.615	4.8	No	No	0	8	7
66	R:R:T213	R:R:Y122	12.522	6.24	No	Yes	0	7	8
67	R:R:W123	R:R:Y131	11.9432	7.72	Yes	Yes	3	4	7
68	R:R:M135	R:R:W123	11.3643	4.65	Yes	Yes	3	7	4
69	R:R:K134	R:R:W123	11.7364	4.64	No	Yes	0	5	4
70	R:R:P158	R:R:Y194	22.0724	5.56	No	Yes	0	6	7
71	R:R:I157	R:R:P158	11.0801	5.08	No	No	0	6	6
72	R:R:F203	R:R:F289	18.0207	21.43	Yes	Yes	1	8	7
73	R:R:F203	R:R:L286	23.0749	3.65	Yes	Yes	0	8	6
74	R:R:L274	R:R:Y214	28.4289	3.52	No	Yes	0	8	9
75	R:R:I277	R:R:Y214	10.4599	6.04	No	Yes	0	8	9
76	R:R:L274	R:R:Y218	26.4496	3.52	No	Yes	0	8	7
77	R:R:V270	R:R:Y218	14.4651	3.79	No	Yes	0	8	7
78	R:R:I225	R:R:V270	10.3411	1.54	No	No	0	5	8
79	R:R:L286	R:R:P287	15.0646	3.28	Yes	No	0	6	9
80	R:R:F316	R:R:P287	13.4315	10.11	No	No	0	5	9
81	R:R:L33	R:R:S325	20.2429	3	No	Yes	0	7	6
82	R:R:S325	R:R:T37	10.1654	3.2	Yes	No	0	6	7
83	R:R:L112	R:R:P206	10.77	3.28	No	Yes	0	5	9
84	R:R:S191	R:R:Y194	11.0801	1.27	No	Yes	0	5	7
85	R:R:M78	R:R:W321	26.5943	3.49	Yes	Yes	1	7	7
86	L:L:?1	R:R:W99	55.3437	7.76	Yes	Yes	1	0	5
87	R:R:A101	R:R:F156	18.5013	5.55	No	Yes	0	6	5
88	R:R:Q160	R:R:V159	20.6977	5.73	No	Yes	0	5	5
89	R:R:F288	R:R:N292	14.3979	4.83	Yes	Yes	1	7	6
90	R:R:L190	R:R:N292	14.615	4.12	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W99	4.9	1	No	Yes	8	5	2	1
R:R:D103	R:R:V77	4.38	1	Yes	No	7	8	1	2
R:R:V77	R:R:W321	6.13	1	No	Yes	8	7	2	2
R:R:F95	R:R:W80	5.01	1	No	No	5	5	2	2
R:R:W80	R:R:W99	5.62	1	No	Yes	5	5	2	1
R:R:E85	R:R:K81	5.4	1	No	Yes	4	6	2	1
R:R:K81	R:R:W99	9.28	1	Yes	Yes	6	5	1	1
R:R:D314	R:R:K81	8.3	1	No	Yes	4	6	2	1
R:R:K81	R:R:W318	6.96	1	Yes	Yes	6	5	1	2
R:R:K81	R:R:W321	4.64	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:K81	4.27	1	Yes	Yes	0	6	0	1
R:R:D314	R:R:E85	7.8	1	No	No	4	4	2	2
R:R:W90	R:R:W99	4.69	1	Yes	Yes	8	5	2	1
R:R:F95	R:R:W99	5.01	1	No	Yes	5	5	2	1
R:R:W321	R:R:W99	3.75	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:W99	7.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V100	6.77	1	Yes	No	0	5	0	1
R:R:D103	R:R:S107	4.42	1	Yes	No	7	7	1	2
R:R:D103	R:R:W321	12.28	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D103	10.28	1	Yes	Yes	0	7	0	1
R:R:I104	R:R:Y194	4.84	0	No	Yes	6	7	1	2
L:L:?1	R:R:I104	14.05	1	Yes	No	0	6	0	1
R:R:S107	R:R:W285	4.94	0	No	Yes	7	8	2	2
R:R:H164	R:R:L190	3.86	0	Yes	Yes	5	4	2	1
R:R:H164	R:R:Y194	6.53	0	Yes	Yes	5	7	2	2
R:R:L190	R:R:N292	4.12	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:L190	8.38	1	Yes	Yes	0	4	0	1
R:R:S198	R:R:Y194	10.17	0	No	Yes	7	7	1	2
L:L:?1	R:R:S198	5.68	1	Yes	No	0	7	0	1
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:N292	R:R:S199	5.96	1	Yes	No	6	7	1	2
R:R:F289	R:R:S202	3.96	1	Yes	No	7	6	1	2
R:R:F203	R:R:W285	4.01	1	Yes	Yes	8	8	2	2
R:R:F203	R:R:F289	21.43	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	11.79	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	4.83	1	Yes	Yes	7	6	1	1
R:R:F288	R:R:F313	5.36	1	Yes	Yes	7	4	1	2
L:L:?1	R:R:F288	12.91	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.53	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	8.32	1	Yes	Yes	0	6	0	1
R:R:W318	R:R:W321	10.31	1	Yes	Yes	5	7	2	2
R:R:A195	R:R:L190	3.15	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9I52_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	253
Number of Links	280
Number of Hubs	37
Number of Links mediated by Hubs	146
Number of Communities	5
Number of Nodes involved in Communities	48
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	51994
Length Of Smallest Path	3
Average Path Length	13.3623
Length of Longest Path	30
Minimum Path Strength	1.42
Average Path Strength	5.993
Maximum Path Strength	16.61
Minimum Path Correlation	0.7
Average Path Correlation	0.94061
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	55.6652
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3973
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • amyloid-beta binding • peptide binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • dopamine binding • G-protein alpha-subunit binding • heterotrimeric G-protein binding • response to nutrient levels • multicellular organismal-level homeostasis • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • ossification • biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • bone mineralization • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • negative regulation of cardiac muscle cell apoptotic process • muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • cardiac muscle cell apoptotic process • negative regulation of apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • negative regulation of muscle cell apoptotic process • negative regulation of cellular process • negative regulation of striated muscle cell apoptotic process • apoptotic process • programmed cell death • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • circulatory system process • actin filament-based process • positive regulation of actin filament-based movement • blood circulation • cardiac muscle cell contraction • regulation of cardiac muscle contraction • positive regulation of cardiac muscle cell contraction • actin filament-based movement • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • positive regulation of striated muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to amyloid-beta • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • response to xenobiotic stimulus • behavior • learning • learning or memory • feeding behavior • cognition • associative learning • conditioned taste aversion • presynaptic modulation of chemical synaptic transmission • regulation of amine metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • memory • establishment of protein localization • nucleocytoplasmic transport • nuclear transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • phasic smooth muscle contraction • peristalsis • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • dopamine transport • catecholamine uptake • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • regulation of neurotransmitter transport • neurotransmitter transport • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • action potential • neuronal action potential • dentate gyrus development • pallium development • hippocampus development • limbic system development • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • calcium ion transmembrane import into cytosol • regulation of release of sequestered calcium ion into cytosol • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • multicellular organismal response to stress • negative regulation of synaptic transmission • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • endosome membrane • endosome • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • apical part of cell • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • early endosome • nucleus • postsynapse • postsynaptic membrane • synaptic membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • dendritic spine • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • ciliary membrane • cell projection membrane • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>9I52_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K P N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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