psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:L11	S:S:N10	13.73	No	No	0	3	4
2	S:S:L11	S:S:Y17	3.52	No	Yes	0	3	7
3	R:R:I29	S:S:F12	7.54	Yes	No	0	4	1
4	R:R:P117	S:S:F12	4.33	No	No	0	4	1
5	S:S:P19	S:S:Y17	5.56	Yes	Yes	6	7	7
6	R:R:F116	S:S:Y17	8.25	Yes	Yes	6	7	7
7	R:R:Q118	S:S:Y17	7.89	No	Yes	6	7	7
8	R:R:T110	S:S:P19	3.5	Yes	Yes	0	7	7
9	R:R:F116	S:S:P19	10.11	Yes	Yes	6	7	7
10	S:S:F38	S:S:S22	5.28	Yes	No	0	7	9
11	R:R:T27	S:S:S22	3.2	No	No	0	5	9
12	S:S:T23	S:S:T35	3.14	No	No	0	5	4
13	S:S:F38	S:S:I24	15.07	Yes	No	0	7	6
14	H:H:?1	S:S:N25	25.87	Yes	No	7	0	7
15	H:H:?2	S:S:N25	4.93	Yes	No	7	0	7
16	S:S:S28	S:S:Y26	5.09	No	Yes	9	4	6
17	S:S:S34	S:S:Y26	5.09	Yes	Yes	9	6	6
18	S:S:I36	S:S:Y26	3.63	No	Yes	0	6	6
19	S:S:L113	S:S:Y26	12.89	No	Yes	0	7	6
20	R:R:S22	S:S:T27	3.2	No	No	0	9	5
21	S:S:S28	S:S:S34	4.89	No	Yes	9	4	6
22	S:S:S28	S:S:T114	3.2	No	No	0	4	7
23	S:S:G115	S:S:I29	3.53	No	No	0	2	4
24	S:S:F116	S:S:I29	5.02	Yes	No	0	7	4
25	R:R:F12	S:S:I29	7.54	No	No	0	1	4
26	S:S:E40	S:S:I36	4.1	No	No	0	3	6
27	S:S:E40	S:S:T37	8.47	No	No	0	3	6
28	R:R:Y26	S:S:F38	4.13	Yes	Yes	0	6	7
29	R:R:T110	S:S:F38	5.19	Yes	Yes	0	7	7
30	S:S:Q42	S:S:V45	5.73	Yes	No	0	7	4
31	S:S:N46	S:S:Q42	11.88	No	Yes	0	5	7
32	R:R:S108	S:S:Q42	5.78	No	Yes	0	7	7
33	R:R:V109	S:S:Q42	4.3	No	Yes	0	5	7
34	R:R:V45	S:S:V45	8.02	No	No	0	4	4
35	R:R:L103	S:S:N46	4.12	No	No	0	7	5
36	S:S:Q51	S:S:S47	4.33	Yes	No	0	4	5
37	S:S:G273	S:S:S47	3.71	No	No	0	3	5
38	S:S:S107	S:S:T48	3.2	No	No	0	5	4
39	R:R:V49	S:S:T48	3.17	No	No	0	6	4
40	S:S:I53	S:S:V49	3.07	No	No	0	7	6
41	R:R:L103	S:S:V49	4.47	No	No	0	7	6
42	S:S:Q51	S:S:Y98	4.51	Yes	Yes	2	4	6
43	S:S:Q51	S:S:V276	8.6	Yes	Yes	2	4	5
44	M:M:Q10	S:S:Q51	3.84	Yes	Yes	2	0	4
45	R:R:I53	S:S:A52	3.25	No	No	0	7	6
46	R:R:A52	S:S:I53	3.25	No	No	0	6	7
47	R:R:F99	S:S:I53	18.84	No	No	0	5	7
48	S:S:M54	S:S:V276	6.09	Yes	Yes	0	7	5
49	S:S:L277	S:S:M54	8.48	No	Yes	0	7	7
50	S:S:M54	S:S:V280	4.56	Yes	No	0	7	7
51	S:S:F55	S:S:R58	4.28	Yes	Yes	2	6	9
52	S:S:F55	S:S:Y98	28.88	Yes	Yes	2	6	6
53	S:S:F55	S:S:F99	3.22	Yes	Yes	0	6	5
54	S:S:F55	S:S:T279	6.49	Yes	Yes	2	6	7
55	R:R:G60	S:S:V57	5.52	No	No	0	9	6
56	S:S:I91	S:S:R58	5.01	Yes	Yes	2	7	9
57	S:S:H94	S:S:R58	5.64	No	Yes	0	8	9
58	S:S:R58	S:S:S95	5.27	Yes	No	0	9	8
59	S:S:L138	S:S:R58	3.64	Yes	Yes	2	8	9
60	S:S:R58	S:S:T279	6.47	Yes	Yes	2	9	7
61	S:S:L283	S:S:R58	7.29	No	Yes	0	8	9
62	S:S:C59	S:S:S95	3.44	No	No	0	7	8
63	S:S:C59	S:S:F99	5.59	No	Yes	0	7	5
64	S:S:A61	S:S:L283	3.15	No	No	0	8	8
65	R:R:L64	S:S:A61	3.15	No	No	0	5	8
66	S:S:A62	S:S:I91	3.25	No	Yes	0	8	7
67	S:S:A62	S:S:I92	3.25	No	No	0	8	5
68	S:S:A63	S:S:I92	3.25	No	No	0	4	5
69	S:S:I67	S:S:L64	4.28	No	No	0	5	5
70	R:R:A61	S:S:L64	3.15	No	No	0	8	5
71	S:S:L88	S:S:T65	4.42	No	Yes	0	9	7
72	S:S:L287	S:S:T65	4.42	No	Yes	0	8	7
73	S:S:P290	S:S:T65	3.5	No	Yes	0	9	7
74	R:R:L64	S:S:T65	5.9	No	Yes	0	5	7
75	S:S:L66	S:S:W70	4.56	No	No	3	5	4
76	S:S:L66	S:S:Q85	6.65	No	No	3	5	5
77	S:S:T72	S:S:V68	4.76	No	No	0	7	7
78	S:S:M294	S:S:V68	6.09	No	No	0	8	7
79	S:S:F81	S:S:M69	3.73	Yes	No	3	9	8
80	S:S:M69	S:S:N84	5.61	No	No	3	8	9
81	S:S:M69	S:S:P290	6.71	No	No	3	8	9
82	S:S:R76	S:S:W70	4	No	No	3	6	4
83	S:S:Q85	S:S:W70	17.52	No	No	3	5	4
84	R:R:L291	S:S:M71	4.24	No	No	0	8	7
85	R:R:W295	S:S:M71	13.96	Yes	No	0	9	7
86	R:R:A298	S:S:T72	5.03	No	No	0	7	7
87	S:S:R76	S:S:S73	5.27	No	No	3	6	8
88	S:S:F81	S:S:S73	5.28	Yes	No	3	9	8
89	S:S:R74	S:S:T297	6.47	Yes	No	0	6	6
90	S:S:N301	S:S:R74	7.23	Yes	Yes	10	6	6
91	R:R:N301	S:S:R74	8.44	Yes	Yes	10	6	6
92	R:R:N306	S:S:R74	4.82	No	Yes	0	5	6
93	S:S:F81	S:S:R76	7.48	Yes	No	3	9	6
94	S:S:P79	S:S:T78	3.5	No	No	0	4	8
95	S:S:I80	S:S:L289	4.28	No	Yes	3	7	9
96	D:D:I469	S:S:I80	10.3	No	No	0	8	7
97	D:D:I471	S:S:I80	4.42	No	No	3	6	7
98	S:S:F81	S:S:Q85	14.05	Yes	No	3	9	5
99	S:S:F148	S:S:I83	5.02	No	No	0	7	7
100	S:S:L289	S:S:N84	10.98	Yes	No	3	9	9
101	S:S:N84	S:S:P290	11.4	No	No	3	9	9
102	S:S:S141	S:S:S87	6.52	No	No	0	6	8
103	S:S:I91	S:S:L138	5.71	Yes	Yes	2	7	8
104	S:S:I91	S:S:V286	4.61	Yes	No	0	7	8
105	S:S:I134	S:S:L93	5.71	No	No	0	5	6
106	S:S:H94	S:S:T131	5.48	No	Yes	0	8	6
107	S:S:H94	S:S:Q135	7.42	No	No	0	8	6
108	S:S:L97	S:S:T131	8.84	No	Yes	0	7	6
109	S:S:Y101	S:S:Y98	10.92	Yes	Yes	2	6	6
110	S:S:L102	S:S:Y98	7.03	No	Yes	2	7	6
111	M:M:Q10	S:S:Y98	6.76	Yes	Yes	2	0	6
112	M:M:P11	S:S:Y98	5.56	Yes	Yes	2	0	6
113	R:R:I53	S:S:F99	17.58	No	Yes	0	7	5
114	S:S:L102	S:S:Y101	3.52	No	Yes	2	7	6
115	M:M:K7	S:S:Y101	4.78	No	Yes	2	0	6
116	M:M:Q10	S:S:Y101	9.02	Yes	Yes	2	0	6
117	M:M:P11	S:S:Y101	12.52	Yes	Yes	2	0	6
118	R:R:N46	S:S:L103	5.49	No	No	0	5	7
119	R:R:V49	S:S:L103	4.47	No	No	0	6	7
120	R:R:T50	S:S:L103	4.42	No	No	0	4	7
121	S:S:F119	S:S:N105	16.92	No	No	0	3	3
122	S:S:D124	S:S:N105	5.39	No	No	0	6	3
123	S:S:Y106	S:S:Y111	5.96	Yes	No	11	5	5
124	S:S:I120	S:S:Y106	16.92	No	Yes	11	7	5
125	S:S:D124	S:S:Y106	3.45	No	Yes	0	6	5
126	M:M:G9	S:S:Y106	8.69	No	Yes	0	0	5
127	S:S:S108	S:S:T110	6.4	No	Yes	0	7	7
128	R:R:Q42	S:S:S108	12.99	Yes	No	0	7	7
129	R:R:Q42	S:S:V109	4.3	Yes	No	0	7	5
130	S:S:F119	S:S:T110	14.27	No	Yes	5	3	7
131	R:R:P19	S:S:T110	3.5	Yes	Yes	5	7	7
132	R:R:F38	S:S:T110	11.67	Yes	Yes	0	7	7
133	S:S:I120	S:S:Y111	12.09	No	No	11	7	5
134	M:M:P8	S:S:Y111	4.17	No	No	0	0	5
135	S:S:F116	S:S:T114	5.19	Yes	No	0	7	7
136	R:R:F38	S:S:T114	3.89	Yes	No	0	7	7
137	R:R:L11	S:S:F116	4.87	Yes	Yes	5	3	7
138	R:R:Y17	S:S:F116	15.47	No	Yes	5	7	7
139	R:R:P19	S:S:F116	8.67	Yes	Yes	5	7	7
140	R:R:F12	S:S:P117	7.22	No	No	0	1	4
141	R:R:P19	S:S:F119	5.78	Yes	No	5	7	3
142	S:S:R122	S:S:V125	10.46	No	No	0	1	4
143	S:S:R122	S:S:Y193	4.12	No	No	0	1	5
144	S:S:N132	S:S:Y128	12.79	No	Yes	0	7	8
145	S:S:T192	S:S:Y128	12.48	No	Yes	0	6	8
146	M:M:P11	S:S:Y128	4.17	Yes	Yes	0	0	8
147	S:S:G129	S:S:M189	3.49	No	No	0	6	5
148	M:M:P11	S:S:T131	6.99	Yes	Yes	0	0	6
149	M:M:M12	S:S:N132	12.62	No	No	0	0	7
150	S:S:L138	S:S:Q135	5.32	Yes	No	0	8	6
151	S:S:Q135	S:S:Y181	4.51	No	Yes	0	6	7
152	S:S:I142	S:S:L138	4.28	No	Yes	0	8	8
153	S:S:V139	S:S:Y181	17.66	No	Yes	0	6	7
154	S:S:A140	S:S:V178	3.39	No	No	0	4	6
155	S:S:I142	S:S:V286	3.07	No	No	0	8	8
156	S:S:E143	S:S:L146	3.98	Yes	No	0	8	9
157	S:S:E143	S:S:G174	6.55	Yes	No	0	8	8
158	S:S:E143	S:S:T177	5.64	Yes	No	0	8	8
159	S:S:E143	S:S:S214	8.62	Yes	No	0	8	9
160	S:S:Q149	S:S:S145	4.33	No	No	0	9	9
161	S:S:L222	S:S:Q149	5.32	No	No	0	9	9
162	S:S:L289	S:S:Q149	11.98	Yes	No	0	9	9
163	S:S:I150	S:S:T167	4.56	Yes	No	0	8	7
164	S:S:I150	S:S:S170	9.29	Yes	No	12	8	8
165	S:S:I150	S:S:M218	4.37	Yes	Yes	12	8	8
166	S:S:I150	S:S:V221	4.61	Yes	No	0	8	7
167	D:D:I469	S:S:V152	10.75	No	No	0	8	8
168	S:S:I153	S:S:K225	4.36	No	No	0	8	9
169	S:S:F154	S:S:G163	4.52	Yes	No	0	9	7
170	S:S:F154	S:S:L166	7.31	Yes	No	0	9	7
171	S:S:F154	S:S:T167	5.19	Yes	No	0	9	7
172	S:S:F154	S:S:K225	8.69	Yes	No	0	9	9
173	D:D:N465	S:S:T155	5.85	No	No	0	8	6
174	D:D:I461	S:S:G156	3.53	No	No	0	7	7
175	S:S:D157	S:S:K160	9.68	No	No	0	6	5
176	D:D:L454	S:S:N158	5.49	No	No	0	9	4
177	S:S:M165	S:S:S168	3.07	No	No	0	2	3
178	S:S:I169	S:S:M165	5.83	No	No	0	4	2
179	S:S:F217	S:S:I169	5.02	No	No	0	6	4
180	S:S:M218	S:S:S170	9.2	Yes	No	12	8	8
181	S:S:F217	S:S:L173	4.87	No	No	0	6	7
182	S:S:S207	S:S:Y181	11.45	No	Yes	0	6	7
183	S:S:L211	S:S:Y181	7.03	No	Yes	0	6	7
184	S:S:F182	S:S:V186	3.93	No	No	0	5	8
185	M:M:M12	S:S:S184	7.67	No	No	0	0	5
186	S:S:K187	S:S:V191	4.55	No	No	0	3	3
187	S:S:K187	S:S:Q200	6.78	No	No	0	3	2
188	S:S:D195	S:S:S197	8.83	No	No	0	3	3
189	S:S:A198	S:S:D195	4.63	No	No	0	1	3
190	S:S:D201	S:S:T199	8.67	No	No	0	2	1
191	S:S:K202	S:S:Q200	4.07	No	No	0	3	2
192	S:S:Q200	S:S:Y203	11.27	No	No	0	2	5
193	S:S:F204	S:S:T208	7.78	No	No	2	5	6
194	M:M:L6	S:S:F204	10.96	No	No	2	0	5
195	M:M:Y13	S:S:F204	13.41	Yes	No	2	0	5
196	S:S:N205	S:S:Y266	5.81	No	Yes	13	6	6
197	M:M:W3	S:S:N205	7.91	No	No	0	0	6
198	M:M:L4	S:S:N205	5.49	No	No	13	0	6
199	S:S:F262	S:S:T208	3.89	Yes	No	2	7	6
200	S:S:T208	S:S:T278	3.14	No	Yes	2	6	5
201	S:S:I209	S:S:Y266	6.04	No	Yes	0	8	6
202	S:S:I215	S:S:L211	4.28	No	No	0	8	6
203	S:S:A212	S:S:F262	9.71	No	Yes	0	7	7
204	S:S:M218	S:S:S214	3.07	Yes	No	0	8	9
205	S:S:A285	S:S:I215	4.87	No	No	0	9	8
206	S:S:N216	S:S:S259	8.94	No	No	0	7	8
207	S:S:F217	S:S:V221	5.24	No	No	0	6	7
208	S:S:S219	S:S:S254	4.89	No	No	0	9	9
209	S:S:L255	S:S:S219	6.01	No	No	0	9	9
210	S:S:F220	S:S:L255	9.74	No	No	0	4	9
211	S:S:F244	S:S:L226	4.87	Yes	No	0	9	9
212	S:S:L226	S:S:L247	5.54	No	No	0	9	9
213	S:S:H245	S:S:I230	5.3	No	No	0	9	9
214	D:D:S455	S:S:S232	6.52	No	No	0	6	7
215	S:S:L238	S:S:R233	12.15	No	Yes	0	8	9
216	S:S:D242	S:S:R233	7.15	No	Yes	8	8	9
217	S:S:F244	S:S:R233	7.48	Yes	Yes	8	9	9
218	D:D:D459	S:S:R233	7.15	No	Yes	0	9	9
219	D:D:Q463	S:S:R233	7.01	No	Yes	8	8	9
220	S:S:K239	S:S:R234	6.19	No	No	0	6	8
221	D:D:K451	S:S:F235	8.69	No	No	0	7	5
222	D:D:F452	S:S:F235	7.5	No	No	0	9	5
223	D:D:F452	S:S:L236	7.31	No	No	0	9	9
224	D:D:A456	S:S:L236	3.15	No	No	0	9	9
225	S:S:G237	S:S:L238	3.42	No	No	0	9	8
226	S:S:F241	S:S:H245	6.79	No	No	0	9	9
227	S:S:F241	S:S:I246	3.77	No	No	0	9	8
228	S:S:D242	S:S:F244	3.58	No	Yes	8	8	9
229	S:S:D242	S:S:H245	13.87	No	No	0	8	9
230	S:S:F244	S:S:S243	3.96	Yes	No	0	9	7
231	D:D:I472	S:S:S243	6.19	Yes	No	0	7	7
232	D:D:I462	S:S:F244	3.77	No	Yes	0	6	9
233	D:D:Q463	S:S:F244	5.86	No	Yes	8	8	9
234	S:S:I246	S:S:W295	15.27	No	No	0	8	9
235	D:D:I471	S:S:L247	4.28	No	No	0	6	9
236	S:S:I249	S:S:W295	4.7	No	No	0	9	9
237	S:S:M250	S:S:Q253	4.08	No	No	0	9	9
238	S:S:M250	S:S:S292	4.6	No	No	0	9	9
239	S:S:Q253	S:S:V257	8.6	No	No	0	9	7
240	S:S:L284	S:S:Q253	3.99	No	No	0	6	9
241	S:S:S254	S:S:S288	6.52	No	No	0	9	8
242	S:S:P258	S:S:V257	3.53	No	No	0	9	7
243	S:S:I261	S:S:V257	3.07	No	No	0	7	7
244	S:S:I261	S:S:L277	4.28	No	No	0	7	7
245	S:S:A281	S:S:I261	4.87	No	No	0	7	7
246	S:S:F262	S:S:T278	6.49	Yes	Yes	2	7	5
247	S:S:A281	S:S:F262	5.55	No	Yes	0	7	7
248	M:M:L4	S:S:Y266	17.58	No	Yes	13	0	6
249	M:M:W1	S:S:S267	6.18	No	No	0	0	4
250	S:S:L268	S:S:T274	4.42	No	No	0	4	6
251	S:S:K269	S:S:P270	3.35	No	No	0	2	2
252	S:S:K269	S:S:Q272	4.07	No	No	0	2	1
253	S:S:N271	S:S:P270	6.52	No	No	0	4	2
254	M:M:H2	S:S:P270	15.25	No	No	0	0	2
255	S:S:Q272	S:S:T274	12.76	No	No	0	1	6
256	M:M:H2	S:S:D275	8.82	No	No	0	0	5
257	M:M:L4	S:S:D275	5.43	No	No	0	0	5
258	M:M:Y13	S:S:D275	3.45	Yes	No	0	0	5
259	S:S:T279	S:S:V276	3.17	Yes	Yes	2	7	5
260	M:M:Y13	S:S:V276	10.09	Yes	Yes	2	0	5
261	M:M:Y13	S:S:T278	3.75	Yes	Yes	2	0	5
262	M:M:Y13	S:S:T279	6.24	Yes	Yes	2	0	7
263	S:S:L283	S:S:L287	6.92	No	No	0	8	8
264	D:D:I471	S:S:L289	4.28	No	Yes	3	6	9
265	R:R:M71	S:S:L291	7.07	Yes	No	0	7	8
266	R:R:M71	S:S:W295	19.78	Yes	No	0	7	9
267	R:R:T72	S:S:A298	3.36	No	No	0	7	7
268	S:S:K304	S:S:N300	4.2	No	No	0	4	7
269	R:R:R74	S:S:N301	14.46	No	Yes	0	6	6
270	R:R:N301	S:S:N301	9.54	Yes	Yes	10	6	6
271	R:R:L11	R:R:N10	5.49	Yes	No	0	3	4
272	R:R:D14	R:R:L11	5.43	No	Yes	0	6	3
273	R:R:L11	R:R:Y17	5.86	Yes	No	5	3	7
274	R:R:D14	R:R:P15	4.83	No	No	0	6	5
275	R:R:S22	R:R:Y17	3.82	No	No	0	9	7
276	R:R:F38	R:R:S22	3.96	Yes	No	0	7	9
277	R:R:T23	R:R:T35	3.14	No	No	0	5	4
278	R:R:I24	R:R:Y26	4.84	No	Yes	0	6	6
279	R:R:F38	R:R:I24	10.05	Yes	No	0	7	6
280	H:H:?1	R:R:N25	9.86	Yes	No	7	0	7
281	H:H:?2	R:R:N25	28.34	Yes	No	7	0	7
282	R:R:S34	R:R:Y26	7.63	No	Yes	0	6	6
283	R:R:I36	R:R:Y26	4.84	No	Yes	0	6	6
284	R:R:L113	R:R:Y26	10.55	No	Yes	0	7	6
285	R:R:S28	R:R:S34	6.52	No	No	0	4	6
286	R:R:I29	R:R:Y30	6.04	Yes	No	0	4	7
287	R:R:G115	R:R:I29	5.29	No	Yes	0	2	4
288	R:R:F116	R:R:I29	7.54	Yes	Yes	0	7	4
289	R:R:E40	R:R:I36	5.47	No	No	0	3	6
290	R:R:Q42	R:R:V45	5.73	Yes	No	0	7	4
291	R:R:N46	R:R:Q42	11.88	No	Yes	0	5	7
292	R:R:S47	R:R:T48	3.2	No	No	0	5	4
293	R:R:Q51	R:R:Y98	5.64	Yes	Yes	1	4	6
294	R:R:L102	R:R:Q51	3.99	No	Yes	1	7	4
295	R:R:Q51	R:R:V276	8.6	Yes	Yes	1	4	5
296	L:L:Q10	R:R:Q51	5.12	Yes	Yes	1	0	4
297	R:R:M54	R:R:V276	4.56	No	Yes	0	7	5
298	R:R:L277	R:R:M54	8.48	No	No	0	7	7
299	R:R:F55	R:R:R58	6.41	Yes	Yes	1	6	9
300	R:R:F55	R:R:H94	4.53	Yes	Yes	1	6	8
301	R:R:F55	R:R:Y98	24.76	Yes	Yes	1	6	6
302	R:R:F55	R:R:V276	3.93	Yes	Yes	1	6	5
303	R:R:F55	R:R:T279	7.78	Yes	No	1	6	7
304	L:L:Y13	R:R:F55	3.09	Yes	Yes	1	0	6
305	R:R:I91	R:R:R58	10.02	Yes	Yes	1	7	9
306	R:R:H94	R:R:R58	5.64	Yes	Yes	1	8	9
307	R:R:R58	R:R:S95	3.95	Yes	No	0	9	8
308	R:R:L138	R:R:R58	3.64	Yes	Yes	1	8	9
309	R:R:R58	R:R:T279	14.23	Yes	No	1	9	7
310	R:R:L283	R:R:R58	6.07	No	Yes	0	8	9
311	R:R:C59	R:R:S95	5.16	No	No	0	7	8
312	R:R:C59	R:R:F99	4.19	No	No	0	7	5
313	R:R:A61	R:R:L283	3.15	No	No	0	8	8
314	R:R:A62	R:R:I91	3.25	No	Yes	0	8	7
315	R:R:A62	R:R:I92	3.25	No	No	0	8	5
316	R:R:A63	R:R:I92	3.25	No	No	0	4	5
317	R:R:L88	R:R:T65	5.9	No	No	0	9	7
318	R:R:L287	R:R:T65	4.42	No	No	0	8	7
319	R:R:P290	R:R:T65	3.5	No	No	0	9	7
320	R:R:L66	R:R:W70	3.42	No	Yes	4	5	4
321	R:R:L66	R:R:Q85	10.65	No	No	4	5	5
322	R:R:T72	R:R:V68	3.17	No	Yes	0	7	7
323	R:R:M294	R:R:V68	4.56	No	Yes	0	8	7
324	R:R:M69	R:R:S73	4.6	Yes	No	4	8	8
325	R:R:F81	R:R:M69	3.73	Yes	Yes	4	9	8
326	R:R:M69	R:R:N84	5.61	Yes	No	4	8	9
327	R:R:M69	R:R:P290	5.03	Yes	No	4	8	9
328	R:R:R76	R:R:W70	4	No	Yes	4	6	4
329	R:R:F81	R:R:W70	4.01	Yes	Yes	4	9	4
330	R:R:Q85	R:R:W70	18.62	No	Yes	4	5	4
331	R:R:R74	R:R:T72	5.17	No	No	0	6	7
332	R:R:F81	R:R:S73	5.28	Yes	No	4	9	8
333	R:R:R74	R:R:T297	14.23	No	No	0	6	6
334	R:R:S75	R:R:T78	4.8	No	No	0	5	8
335	R:R:F81	R:R:R76	9.62	Yes	No	4	9	6
336	R:R:F81	R:R:T78	3.89	Yes	No	0	9	8
337	R:R:I80	R:R:L289	4.28	No	Yes	0	7	9
338	R:R:F81	R:R:Q85	11.71	Yes	No	4	9	5
339	R:R:I83	R:R:S145	3.1	No	No	0	7	9
340	R:R:F148	R:R:I83	3.77	No	No	0	7	7
341	R:R:L289	R:R:N84	8.24	Yes	No	0	9	9
342	R:R:N84	R:R:P290	11.4	No	No	4	9	9
343	R:R:S141	R:R:S87	6.52	No	No	0	6	8
344	R:R:I142	R:R:S87	3.1	Yes	No	1	8	8
345	R:R:S87	R:R:V286	4.85	No	No	1	8	8
346	R:R:I134	R:R:L90	4.28	No	Yes	0	5	4
347	R:R:I91	R:R:L138	4.28	Yes	Yes	1	7	8
348	R:R:I91	R:R:V286	4.61	Yes	No	1	7	8
349	R:R:I134	R:R:L93	4.28	No	No	0	5	6
350	R:R:H94	R:R:T131	4.11	Yes	Yes	0	8	6
351	R:R:H94	R:R:Q135	7.42	Yes	No	0	8	6
352	L:L:Y13	R:R:H94	4.36	Yes	Yes	1	0	8
353	R:R:A130	R:R:L97	3.15	No	No	0	7	7
354	R:R:L97	R:R:T131	5.9	No	Yes	0	7	6
355	R:R:Y101	R:R:Y98	8.94	Yes	Yes	1	6	6
356	R:R:L102	R:R:Y98	4.69	No	Yes	1	7	6
357	L:L:Q10	R:R:Y98	4.51	Yes	Yes	1	0	6
358	L:L:P11	R:R:Y98	4.17	Yes	Yes	1	0	6
359	R:R:S107	R:R:Y101	5.09	No	Yes	0	5	6
360	L:L:Q10	R:R:Y101	7.89	Yes	Yes	1	0	6
361	L:L:P11	R:R:Y101	12.52	Yes	Yes	1	0	6
362	R:R:F119	R:R:N105	18.12	No	No	0	3	3
363	R:R:D124	R:R:N105	6.73	Yes	No	0	6	3
364	R:R:I120	R:R:Y106	14.51	No	No	0	7	5
365	R:R:D124	R:R:Y106	3.45	Yes	No	0	6	5
366	L:L:G9	R:R:Y106	5.79	No	No	0	0	5
367	R:R:S108	R:R:T110	3.2	No	Yes	0	7	7
368	R:R:F119	R:R:T110	7.78	No	Yes	0	3	7
369	R:R:I120	R:R:Y111	12.09	No	No	0	7	5
370	R:R:F116	R:R:T114	7.78	Yes	No	0	7	7
371	R:R:F116	R:R:Q118	9.37	Yes	No	6	7	7
372	R:R:I120	R:R:V196	6.14	No	No	0	7	1
373	R:R:D124	R:R:S121	10.31	Yes	No	0	6	4
374	R:R:R122	R:R:V125	7.85	No	No	0	1	4
375	R:R:R122	R:R:Y193	3.09	No	No	0	1	5
376	R:R:G123	R:R:H126	4.77	No	No	0	5	6
377	R:R:N132	R:R:Y128	6.98	No	Yes	0	7	8
378	R:R:T192	R:R:Y128	16.23	No	Yes	0	6	8
379	L:L:P11	R:R:Y128	4.17	Yes	Yes	0	0	8
380	R:R:G129	R:R:M189	3.49	No	No	0	6	5
381	L:L:P11	R:R:T131	8.74	Yes	Yes	0	0	6
382	R:R:M189	R:R:N132	4.21	No	No	0	5	7
383	L:L:M12	R:R:N132	8.41	Yes	No	0	0	7
384	R:R:Q135	R:R:Y181	6.76	No	Yes	0	6	7
385	L:L:M12	R:R:Q135	6.8	Yes	No	0	0	6
386	R:R:F182	R:R:V136	3.93	No	No	0	5	5
387	R:R:I142	R:R:L138	4.28	Yes	Yes	1	8	8
388	R:R:V139	R:R:Y181	16.4	No	Yes	0	6	7
389	R:R:A140	R:R:V178	3.39	No	No	0	4	6
390	R:R:I142	R:R:V286	3.07	Yes	No	1	8	8
391	R:R:E143	R:R:G174	6.55	Yes	No	0	8	8
392	R:R:E143	R:R:T177	7.06	Yes	No	0	8	8
393	R:R:E143	R:R:S214	8.62	Yes	No	0	8	9
394	R:R:L146	R:R:M218	5.65	No	Yes	0	9	8
395	R:R:F171	R:R:V147	3.93	No	No	0	3	7
396	R:R:L222	R:R:Q149	6.65	No	No	0	9	9
397	R:R:L289	R:R:Q149	14.64	Yes	No	0	9	9
398	R:R:I150	R:R:T167	4.56	Yes	No	0	8	7
399	R:R:I150	R:R:S170	7.74	Yes	No	14	8	8
400	R:R:I150	R:R:M218	7.29	Yes	Yes	14	8	8
401	R:R:I150	R:R:V221	7.68	Yes	No	0	8	7
402	R:R:I153	R:R:L222	7.14	No	No	0	8	9
403	R:R:I153	R:R:K225	4.36	No	No	0	8	9
404	R:R:F154	R:R:G163	9.03	Yes	No	0	9	7
405	R:R:F154	R:R:L166	7.31	Yes	No	0	9	7
406	R:R:F154	R:R:T167	5.19	Yes	No	0	9	7
407	R:R:F154	R:R:V221	3.93	Yes	No	0	9	7
408	R:R:F154	R:R:K225	6.2	Yes	No	0	9	9
409	R:R:F217	R:R:L166	3.65	Yes	No	0	6	7
410	R:R:F217	R:R:I169	6.28	Yes	No	0	6	4
411	R:R:M218	R:R:S170	7.67	Yes	No	14	8	8
412	R:R:F171	R:R:I175	5.02	No	No	0	3	4
413	R:R:F217	R:R:L173	3.65	Yes	No	0	6	7
414	R:R:L210	R:R:T177	7.37	No	No	0	6	8
415	R:R:M180	R:R:Y203	4.79	No	Yes	0	6	5
416	R:R:S207	R:R:Y181	15.26	No	Yes	0	6	7
417	R:R:L211	R:R:Y181	7.03	No	Yes	0	6	7
418	R:R:F182	R:R:V186	5.24	No	No	0	5	8
419	R:R:V183	R:R:Y203	3.79	No	Yes	0	6	5
420	R:R:S184	R:R:Y203	3.82	No	Yes	0	5	5
421	R:R:S184	R:R:S207	4.89	No	No	0	5	6
422	L:L:M12	R:R:S184	4.6	Yes	No	0	0	5
423	R:R:K187	R:R:Q200	4.07	No	No	15	3	2
424	R:R:K187	R:R:Y203	3.58	No	Yes	15	3	5
425	R:R:A198	R:R:D195	4.63	No	No	0	1	3
426	R:R:Q200	R:R:Y203	9.02	No	Yes	15	2	5
427	R:R:D201	R:R:N205	4.04	No	Yes	0	2	6
428	L:L:Q5	R:R:D201	6.53	No	No	0	0	2
429	L:L:L6	R:R:D201	4.07	Yes	No	0	0	2
430	L:L:W3	R:R:K202	10.44	No	No	0	0	3
431	R:R:F204	R:R:T208	7.78	Yes	Yes	1	5	6
432	L:L:L4	R:R:F204	3.65	Yes	Yes	1	0	5
433	L:L:L6	R:R:F204	15.83	Yes	Yes	1	0	5
434	L:L:M12	R:R:F204	7.46	Yes	Yes	0	0	5
435	L:L:Y13	R:R:F204	11.35	Yes	Yes	1	0	5
436	R:R:N205	R:R:Y266	3.49	Yes	Yes	1	6	6
437	L:L:W3	R:R:N205	13.56	No	Yes	0	0	6
438	L:L:L4	R:R:N205	5.49	Yes	Yes	1	0	6
439	R:R:T208	R:R:Y266	6.24	Yes	Yes	1	6	6
440	R:R:T208	R:R:T278	3.14	Yes	Yes	0	6	5
441	L:L:L4	R:R:T208	4.42	Yes	Yes	1	0	6
442	R:R:I209	R:R:Y266	6.04	No	Yes	0	8	6
443	R:R:I215	R:R:L211	4.28	No	No	0	8	6
444	R:R:A212	R:R:F262	9.71	No	No	0	7	7
445	R:R:M218	R:R:S214	3.07	Yes	No	0	8	9
446	R:R:A285	R:R:I215	4.87	No	No	0	9	8
447	R:R:F220	R:R:N216	7.25	No	No	16	4	7
448	R:R:L255	R:R:N216	4.12	Yes	No	16	9	7
449	R:R:N216	R:R:S259	7.45	No	No	0	7	8
450	R:R:F217	R:R:V221	5.24	Yes	No	0	6	7
451	R:R:S219	R:R:S254	4.89	No	No	0	9	9
452	R:R:L255	R:R:S219	4.5	Yes	No	0	9	9
453	R:R:F220	R:R:L255	10.96	No	Yes	16	4	9
454	R:R:L222	R:R:S251	6.01	No	No	0	9	8
455	R:R:I227	R:R:L248	5.71	No	No	0	5	8
456	R:R:H245	R:R:I230	11.93	No	No	0	9	9
457	R:R:L238	R:R:R233	8.5	No	No	0	8	9
458	R:R:D242	R:R:R233	7.15	No	No	0	8	9
459	R:R:F244	R:R:R233	6.41	No	No	0	9	9
460	R:R:G237	R:R:L238	3.42	No	No	0	9	8
461	R:R:F241	R:R:H245	7.92	No	No	0	9	9
462	R:R:F241	R:R:I246	3.77	No	Yes	0	9	8
463	R:R:D242	R:R:H245	8.82	No	No	0	8	9
464	R:R:A296	R:R:S243	3.42	No	No	0	9	7
465	R:R:I246	R:R:W295	18.79	Yes	Yes	0	8	9
466	R:R:I249	R:R:W295	4.7	No	Yes	0	9	9
467	R:R:M250	R:R:S292	3.07	No	No	0	9	9
468	R:R:M250	R:R:W295	3.49	No	Yes	0	9	9
469	R:R:Q253	R:R:V257	7.16	No	No	0	9	7
470	R:R:L284	R:R:Q253	3.99	No	No	0	6	9
471	R:R:S254	R:R:S288	6.52	No	No	0	9	8
472	R:R:P258	R:R:V257	3.53	No	No	0	9	7
473	R:R:I261	R:R:L277	4.28	No	No	0	7	7
474	R:R:A281	R:R:I261	3.25	No	No	0	7	7
475	R:R:F262	R:R:T278	6.49	No	Yes	0	7	5
476	R:R:A281	R:R:F262	5.55	No	No	0	7	7
477	L:L:L4	R:R:Y266	11.72	Yes	Yes	1	0	6
478	R:R:L268	R:R:T274	7.37	No	No	0	4	6
479	R:R:K269	R:R:P270	3.35	No	No	0	2	2
480	R:R:N271	R:R:P270	4.89	No	No	0	4	2
481	L:L:H2	R:R:P270	10.68	No	No	0	0	2
482	L:L:H2	R:R:D275	10.08	No	No	0	0	5
483	L:L:L4	R:R:D275	4.07	Yes	No	1	0	5
484	L:L:Y13	R:R:D275	5.75	Yes	No	1	0	5
485	L:L:Y13	R:R:V276	7.57	Yes	Yes	1	0	5
486	L:L:Y13	R:R:T278	4.99	Yes	Yes	0	0	5
487	R:R:L283	R:R:L287	8.3	No	No	0	8	8
488	R:R:L289	R:R:S292	4.5	Yes	No	0	9	9
489	R:R:K304	R:R:N300	6.99	No	No	0	4	7
490	R:R:N301	R:R:T305	10.24	Yes	No	0	6	4
491	R:R:N306	R:R:T305	4.39	No	No	0	5	4
492	M:M:L6	M:M:Y13	3.52	No	Yes	2	0	0
493	M:M:K7	M:M:P8	3.35	No	No	0	0	0
494	M:M:K7	M:M:Q10	6.78	No	Yes	2	0	0
495	M:M:P11	M:M:Q10	3.16	Yes	Yes	2	0	0
496	M:M:Q10	M:M:Y13	4.51	Yes	Yes	2	0	0
497	L:L:L4	L:L:Y13	5.86	Yes	Yes	1	0	0
498	L:L:L6	L:L:Y13	4.69	Yes	Yes	1	0	0
499	L:L:K7	L:L:Q10	13.56	No	Yes	0	0	0
500	L:L:P11	L:L:Q10	3.16	Yes	Yes	1	0	0
501	L:L:Q10	L:L:Y13	6.76	Yes	Yes	1	0	0
502	D:D:F452	D:D:I453	3.77	No	No	0	9	8
503	D:D:N465	D:D:Q464	3.96	No	No	0	8	7
504	D:D:K468	D:D:Q464	4.07	No	No	0	7	7
505	D:D:I472	D:D:L466	5.71	Yes	No	0	7	9
506	H:H:?1	H:H:?2	12.26	Yes	Yes	7	0	0
507	R:R:K304	R:R:S303	3.06	No	No	0	4	4
508	R:R:M294	S:S:V68	3.04	No	No	0	8	7
509	S:S:I83	S:S:T144	3.04	No	No	0	7	3
510	S:S:M218	S:S:V147	3.04	Yes	No	0	8	7
511	S:S:M180	S:S:V183	3.04	No	No	0	6	6
512	R:R:V68	S:S:M294	3.04	Yes	No	0	7	8
513	R:R:M54	R:R:V280	3.04	No	No	0	7	7
514	R:R:M71	R:R:V68	3.04	Yes	Yes	0	7	7
515	R:R:I83	R:R:T144	3.04	No	No	0	7	3
516	R:R:I142	R:R:T282	3.04	Yes	No	0	8	5
517	R:R:M218	R:R:V147	3.04	Yes	No	0	8	7
518	S:S:F99	S:S:G56	3.01	Yes	No	0	5	7
519	R:R:F99	R:R:G56	3.01	No	No	0	5	7
520	S:S:L222	S:S:S251	3	No	Yes	0	9	8
521	S:S:L226	S:S:S251	3	No	Yes	0	9	8
522	R:R:K151	R:R:T167	3	No	No	0	6	7
523	R:R:L164	R:R:S168	3	No	No	0	1	3
524	R:R:L226	R:R:S251	3	No	No	0	9	8
525	R:R:L247	R:R:S292	3	No	No	0	9	9
526	S:S:L90	S:S:V86	2.98	No	No	0	4	4
527	R:R:L41	S:S:V109	2.98	No	No	0	5	5
528	R:R:L41	R:R:V109	2.98	No	No	0	5	5
529	R:R:L90	R:R:V86	2.98	Yes	No	0	4	4
530	R:R:L248	R:R:V223	2.98	No	No	0	8	6
531	R:R:L255	R:R:V223	2.98	Yes	No	0	9	6
532	S:S:L210	S:S:T177	2.95	No	No	0	6	8
533	L:L:L6	R:R:T199	2.95	Yes	No	0	0	1
534	R:R:D124	R:R:S104	2.94	Yes	No	0	6	6
535	R:R:D195	R:R:S197	2.94	No	No	0	3	3
536	R:R:I67	R:R:M71	2.92	No	Yes	0	5	7
537	S:S:I82	S:S:K77	2.91	No	No	0	5	6
538	S:S:I190	S:S:K187	2.91	No	No	0	4	3
539	S:S:G129	S:S:Y128	2.9	No	Yes	0	6	8
540	S:S:G188	S:S:Y128	2.9	No	Yes	0	8	8
541	S:S:I134	S:S:L90	2.85	No	No	0	5	4
542	S:S:I134	S:S:L97	2.85	No	No	0	5	7
543	S:S:I142	S:S:L146	2.85	No	No	0	8	9
544	S:S:E143	S:S:V178	2.85	Yes	No	0	8	6
545	S:S:I153	S:S:L222	2.85	No	No	0	8	9
546	S:S:I162	S:S:L166	2.85	No	No	0	4	7
547	S:S:I230	S:S:L248	2.85	No	No	0	9	8
548	S:S:I260	S:S:L256	2.85	No	No	0	8	6
549	R:R:E143	R:R:V178	2.85	Yes	No	0	8	6
550	R:R:I162	R:R:L166	2.85	No	No	0	4	7
551	R:R:I260	R:R:L256	2.85	No	No	0	8	6
552	R:R:T16	S:S:Q118	2.83	No	No	0	5	7
553	R:R:Q272	R:R:T274	2.83	No	No	0	1	6
554	R:R:E40	R:R:T37	2.82	No	No	0	3	6
555	S:S:L137	S:S:L90	2.77	No	No	0	6	4
556	S:S:A229	S:S:F244	2.77	No	Yes	0	9	9
557	S:S:L264	S:S:L268	2.77	No	No	0	7	4
558	R:R:L113	R:R:L44	2.77	No	No	0	7	4
559	R:R:L137	R:R:L90	2.77	No	Yes	0	6	4
560	R:R:L138	R:R:L90	2.77	Yes	Yes	0	8	4
561	R:R:L226	R:R:L248	2.77	No	No	0	9	8
562	R:R:A229	R:R:F244	2.77	No	No	0	9	9
563	R:R:M250	R:R:Q253	2.72	No	No	0	9	9
564	S:S:D14	S:S:L11	2.71	No	No	0	6	3
565	M:M:L6	S:S:D201	2.71	No	No	0	0	2
566	R:R:K269	R:R:Q272	2.71	No	No	0	2	1
567	H:H:?1	S:S:T23	2.65	Yes	No	0	0	5
568	R:R:F12	R:R:S9	2.64	No	No	0	1	7
569	S:S:F182	S:S:V136	2.62	No	No	0	5	5
570	S:S:F171	S:S:V147	2.62	No	No	0	3	7
571	M:M:Q5	S:S:D201	2.61	No	No	0	0	2
572	S:S:R58	S:S:T282	2.59	Yes	No	0	9	5
573	S:S:S184	S:S:Y203	2.54	No	No	0	5	5
574	R:R:S9	R:R:Y13	2.54	No	No	0	7	2
575	R:R:S197	R:R:Y111	2.54	No	No	0	3	5
576	D:D:I469	S:S:F148	2.51	No	No	0	8	7
577	R:R:K239	R:R:R234	2.48	No	No	0	6	8
578	L:L:W1	R:R:S267	2.47	No	No	0	0	4
579	R:R:F89	R:R:L66	2.44	No	No	0	4	5
580	S:S:M180	S:S:Y203	2.39	No	No	0	6	5
581	M:M:W1	S:S:I263	2.35	No	No	0	0	7
582	S:S:C59	S:S:G60	1.96	No	No	0	7	9
583	R:R:C59	R:R:G60	1.96	No	No	0	7	9
584	M:M:W1	S:S:Y266	1.93	No	Yes	0	0	6
585	L:L:W1	R:R:Y266	1.93	No	Yes	0	0	6
586	S:S:G31	S:S:S34	1.86	No	Yes	0	8	6
587	S:S:G33	S:S:S34	1.86	No	Yes	0	2	6
588	R:R:G31	R:R:S28	1.86	No	No	0	8	4
589	R:R:G33	R:R:S34	1.86	No	No	0	2	6
590	R:R:G273	R:R:S47	1.86	No	No	0	3	5
591	R:R:V57	S:S:G56	1.84	No	No	0	6	7
592	R:R:V57	S:S:G60	1.84	No	No	0	6	9
593	R:R:T110	S:S:G20	1.82	Yes	No	0	7	3
594	D:D:G470	S:S:T78	1.82	No	No	0	9	8
595	R:R:G20	S:S:T110	1.82	No	Yes	0	3	7
596	S:S:G156	S:S:T155	1.82	No	No	0	7	6
597	R:R:G156	R:R:T155	1.82	No	No	0	7	6
598	L:L:P8	R:R:S197	1.78	No	No	0	0	3
599	S:S:P117	S:S:V196	1.77	No	No	0	4	1
600	D:D:G470	D:D:I472	1.76	No	Yes	0	9	7
601	S:S:P15	S:S:T16	1.75	No	No	0	5	5
602	R:R:P15	R:R:T16	1.75	No	No	0	5	5
603	R:R:P79	R:R:T78	1.75	No	No	0	4	8
604	R:R:G237	R:R:K239	1.74	No	No	0	9	6
605	S:S:C252	S:S:V223	1.71	No	No	0	7	6
606	S:S:A296	S:S:S243	1.71	No	No	0	9	7
607	R:R:C252	R:R:V223	1.71	No	No	0	7	6
608	S:S:G43	S:S:N46	1.7	No	No	0	1	5
609	S:S:A185	S:S:V136	1.7	No	No	0	6	5
610	S:S:A198	S:S:V191	1.7	No	No	0	1	3
611	R:R:A185	R:R:V136	1.7	No	No	0	6	5
612	R:R:A198	R:R:V191	1.7	No	No	0	1	3
613	S:S:D157	S:S:G156	1.68	No	No	0	6	7
614	S:S:D157	S:S:G163	1.68	No	No	0	6	7
615	S:S:A265	S:S:T278	1.68	No	Yes	0	8	5
616	R:R:D39	R:R:G20	1.68	No	No	0	1	3
617	R:R:A265	R:R:T278	1.68	No	Yes	0	8	5
618	R:R:G273	R:R:Q51	1.64	No	Yes	0	3	4
619	S:S:N18	S:S:P19	1.63	No	Yes	0	7	7
620	S:S:S251	S:S:S254	1.63	Yes	No	0	8	9
621	R:R:N18	R:R:P19	1.63	No	Yes	0	7	7
622	S:S:S141	S:S:V86	1.62	No	No	0	6	4
623	S:S:S87	S:S:V286	1.62	No	No	0	8	8
624	S:S:S251	S:S:V223	1.62	Yes	No	0	8	6
625	S:S:A299	S:S:I246	1.62	No	No	0	6	8
626	R:R:A296	R:R:I246	1.62	No	Yes	0	9	8
627	R:R:A299	R:R:I246	1.62	No	Yes	0	6	8
628	S:S:D14	S:S:P15	1.61	No	No	0	6	5
629	S:S:A206	S:S:M180	1.61	No	No	0	5	6
630	M:M:M12	S:S:A185	1.61	No	No	0	0	6
631	R:R:A206	R:R:M180	1.61	No	No	0	5	6
632	L:L:M12	R:R:A185	1.61	Yes	No	0	0	6
633	S:S:S75	S:S:T78	1.6	No	No	0	5	8
634	R:R:S293	R:R:T297	1.6	No	No	0	9	6
635	S:S:G123	S:S:H126	1.59	No	No	0	5	6
636	S:S:T192	S:S:V125	1.59	No	No	0	6	4
637	S:S:T131	S:S:V127	1.59	Yes	No	0	6	5
638	S:S:T179	S:S:V183	1.59	No	No	0	5	6
639	R:R:T192	R:R:V125	1.59	No	No	0	6	4
640	R:R:T131	R:R:V127	1.59	Yes	No	0	6	5
641	R:R:T155	R:R:V152	1.59	No	No	0	6	8
642	S:S:A112	S:S:L44	1.58	No	No	0	3	4
643	R:R:A112	R:R:L44	1.58	No	No	0	3	4
644	R:R:A176	R:R:L210	1.58	No	No	0	6	6
645	S:S:A302	S:S:N301	1.56	No	Yes	0	5	6
646	R:R:I80	R:R:S145	1.55	No	No	0	7	9
647	R:R:I263	R:R:S259	1.55	No	No	0	7	8
648	S:S:I227	S:S:V223	1.54	No	No	0	5	6
649	R:R:I82	R:R:V86	1.54	No	No	0	5	4
650	R:R:I190	R:R:V191	1.54	No	No	0	4	3
651	D:D:I461	D:D:V457	1.54	No	No	0	7	8
652	S:S:K100	S:S:V127	1.52	No	No	0	4	5
653	S:S:I175	S:S:T179	1.52	No	No	0	4	5
654	R:R:K100	R:R:V127	1.52	No	No	0	4	5
655	R:R:I175	R:R:T179	1.52	No	No	0	4	5
656	S:S:M54	S:S:T50	1.51	Yes	No	0	7	4
657	S:S:K151	S:S:T167	1.5	No	No	0	6	7
658	S:S:L41	S:S:V45	1.49	No	No	0	5	4
659	R:R:V109	S:S:L41	1.49	No	No	0	5	5
660	S:S:L228	S:S:V224	1.49	No	No	0	3	4
661	R:R:L228	R:R:V224	1.49	No	No	0	3	4
662	D:D:L454	D:D:T458	1.47	No	No	0	9	8
663	S:S:I133	S:S:M189	1.46	No	No	0	6	5
664	S:S:N306	S:S:T305	1.46	No	No	0	5	4
665	R:R:N301	S:S:T305	1.46	Yes	No	0	6	4
666	R:R:N25	R:R:T35	1.46	No	No	0	7	4
667	R:R:N32	R:R:T27	1.46	No	No	0	5	5
668	R:R:I162	R:R:M165	1.46	No	No	0	4	2
669	R:R:I169	R:R:M165	1.46	No	No	0	4	2
670	R:R:G188	R:R:Y128	1.45	No	Yes	0	8	8
671	D:D:I472	D:D:K467	1.45	Yes	No	0	7	8
672	S:S:I260	S:S:L264	1.43	No	No	0	8	7
673	R:R:I133	R:R:L137	1.43	No	No	0	6	6
674	R:R:I260	R:R:L264	1.43	No	No	0	8	7
675	S:S:L113	S:S:L44	1.38	No	No	0	7	4
676	R:R:D157	R:R:K160	1.38	No	No	0	6	5
677	R:R:L264	R:R:L268	1.38	No	No	0	7	4
678	S:S:L255	S:S:N216	1.37	No	No	0	9	7
679	S:S:D195	S:S:N194	1.35	No	No	0	3	1
680	S:S:F12	S:S:S9	1.32	No	No	0	1	7
681	S:S:N18	S:S:Q21	1.32	No	No	0	7	4
682	H:H:?2	S:S:T27	1.32	Yes	No	0	0	5
683	S:S:D39	S:S:E40	1.3	No	No	0	1	3
684	S:S:S104	S:S:Y101	1.27	No	Yes	0	6	6
685	S:S:S104	S:S:Y106	1.27	No	Yes	0	6	5
686	S:S:F81	S:S:I82	1.26	Yes	No	0	9	5
687	S:S:I227	S:S:R231	1.25	No	No	0	5	5
688	R:R:I227	R:R:R231	1.25	No	No	0	5	5
689	R:R:K77	R:R:R76	1.24	No	No	0	6	6
690	H:H:?2	S:S:N32	1.23	Yes	No	0	0	5
691	S:S:F89	S:S:L66	1.22	No	No	0	4	5
692	S:S:L228	S:S:R231	1.21	No	No	0	3	5
693	R:R:L228	R:R:R231	1.21	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:Y17	6.305	4	6	7
2	S:S:P19	5.2	4	6	7
3	S:S:Y26	6.675	4	9	6
4	S:S:S34	3.425	4	9	6
5	S:S:F38	7.4175	4	0	7
6	S:S:Q42	6.9225	4	0	7
7	S:S:Q51	5.32	4	2	4
8	S:S:M54	5.16	4	0	7
9	S:S:F55	10.7175	4	2	6
10	S:S:R58	5.02375	8	2	9
11	S:S:T65	4.56	4	0	7
12	S:S:R74	6.74	4	10	6
13	S:S:F81	6.36	5	3	9
14	S:S:I91	4.645	4	2	7
15	S:S:Y98	10.61	6	2	6
16	S:S:F99	7.35	4	0	5
17	S:S:Y101	7.005	6	2	6
18	S:S:Y106	7.258	5	11	5
19	S:S:T110	7.532	5	5	7
20	S:S:F116	7.844	5	5	7
21	S:S:Y128	7.048	5	0	8
22	S:S:T131	5.725	4	0	6
23	S:S:L138	4.7375	4	2	8
24	S:S:E143	5.528	5	0	8
25	S:S:I150	5.7075	4	12	8
26	S:S:F154	6.4275	4	0	9
27	S:S:Y181	10.1625	4	0	7
28	S:S:M218	4.92	4	12	8
29	S:S:R233	8.188	5	8	9
30	S:S:F244	4.61286	7	8	9
31	S:S:S251	2.3125	4	0	8
32	S:S:F262	6.41	4	2	7
33	S:S:Y266	7.84	4	13	6
34	S:S:V276	6.9875	4	2	5
35	S:S:T278	3.765	4	2	5
36	S:S:T279	5.5925	4	2	7
37	S:S:L289	7.88	4	3	9
38	S:S:N301	8.1975	4	10	6
39	R:R:L11	5.4125	4	5	3
40	R:R:P19	4.895	4	5	7
41	R:R:Y26	6.398	5	0	6
42	R:R:I29	6.6025	4	0	4
43	R:R:F38	7.3925	4	0	7
44	R:R:Q42	8.725	4	0	7
45	R:R:Q51	4.998	5	1	4
46	R:R:F55	8.41667	6	1	6
47	R:R:R58	7.13714	7	1	9
48	R:R:V68	3.4525	4	0	7
49	R:R:M69	4.7425	4	4	8
50	R:R:W70	7.5125	4	4	4
51	R:R:M71	8.2025	4	0	7
52	R:R:F81	6.37333	6	4	9
53	R:R:L90	3.2	4	0	4
54	R:R:I91	5.54	4	1	7
55	R:R:H94	5.212	5	1	8
56	R:R:Y98	8.785	6	1	6
57	R:R:Y101	8.61	4	1	6
58	R:R:T110	4.298	5	0	7
59	R:R:F116	8.61	5	6	7
60	R:R:D124	5.8575	4	0	6
61	R:R:Y128	7.2075	4	0	8
62	R:R:T131	5.085	4	0	6
63	R:R:L138	3.7425	4	1	8
64	R:R:I142	3.3725	4	1	8
65	R:R:E143	6.27	4	0	8
66	R:R:I150	6.8175	4	14	8
67	R:R:F154	6.332	5	0	9
68	R:R:Y181	11.3625	4	0	7
69	R:R:Y203	5	5	15	5
70	R:R:F204	9.214	5	1	5
71	R:R:N205	6.645	4	1	6
72	R:R:T208	5.395	4	1	6
73	R:R:F217	4.705	4	0	6
74	R:R:M218	5.344	5	14	8
75	R:R:I246	6.45	4	0	8
76	R:R:L255	5.64	4	16	9
77	R:R:Y266	5.884	5	1	6
78	R:R:V276	6.165	4	1	5
79	R:R:T278	4.075	4	0	5
80	R:R:L289	7.915	4	0	9
81	R:R:W295	10.235	4	0	9
82	R:R:N301	7.42	4	10	6
83	M:M:Q10	5.67833	6	2	0
84	M:M:P11	6.48	5	2	0
85	M:M:Y13	6.42429	7	2	0
86	L:L:L4	5.86833	6	1	0
87	L:L:L6	6.885	4	1	0
88	L:L:Q10	6.83333	6	1	0
89	L:L:P11	6.552	5	1	0
90	L:L:M12	5.776	5	0	0
91	L:L:Y13	6.04667	9	1	0
92	D:D:I472	3.7775	4	0	7
93	H:H:?1	12.66	4	7	0
94	H:H:?2	9.616	5	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T110	S:S:P19	10.311	3.5	Yes	Yes	0	7	7
2	R:R:T110	S:S:F38	20.841	5.19	Yes	Yes	0	7	7
3	R:R:Y26	S:S:F38	20.9739	4.13	Yes	Yes	0	6	7
4	R:R:I24	R:R:Y26	21.2031	4.84	No	Yes	0	6	6
5	R:R:F38	R:R:I24	21.2195	10.05	Yes	No	0	7	6
6	R:R:F38	S:S:T114	10.3908	3.89	Yes	No	0	7	7
7	S:S:S28	S:S:T114	12.0424	3.2	No	No	0	4	7
8	R:R:S108	R:R:T110	18.8734	3.2	No	Yes	0	7	7
9	R:R:S108	S:S:Q42	19.0322	5.78	No	Yes	0	7	7
10	S:S:Q42	S:S:V45	81.6349	5.73	Yes	No	0	7	4
11	S:S:N46	S:S:Q42	100	11.88	No	Yes	0	5	7
12	R:R:V45	S:S:V45	81.6599	8.02	No	No	0	4	4
13	R:R:L103	S:S:N46	99.7482	4.12	No	No	0	7	5
14	R:R:F38	S:S:T110	25.5355	11.67	Yes	Yes	0	7	7
15	S:S:F119	S:S:T110	91.3766	14.27	No	Yes	5	3	7
16	S:S:F119	S:S:N105	98.3937	16.92	No	No	0	3	3
17	S:S:D124	S:S:N105	98.303	5.39	No	No	0	6	3
18	S:S:D124	S:S:Y106	98.2107	3.45	No	Yes	0	6	5
19	S:S:S104	S:S:Y106	97.1065	1.27	No	Yes	0	6	5
20	S:S:S104	S:S:Y101	97.0048	1.27	No	Yes	0	6	6
21	S:S:Y101	S:S:Y98	57.4601	10.92	Yes	Yes	2	6	6
22	M:M:Q10	S:S:Y101	22.5497	9.02	Yes	Yes	2	0	6
23	R:R:Q42	R:R:V45	81.6795	5.73	Yes	No	0	7	4
24	S:S:I53	S:S:V49	99.4901	3.07	No	No	0	7	6
25	R:R:L103	S:S:V49	99.6199	4.47	No	No	0	7	6
26	M:M:Q10	M:M:Y13	19.6789	4.51	Yes	Yes	2	0	0
27	S:S:F55	S:S:Y98	57.2216	28.88	Yes	Yes	2	6	6
28	R:R:F99	S:S:I53	99.2258	18.84	No	No	0	5	7
29	S:S:M54	S:S:V276	13.881	6.09	Yes	Yes	0	7	5
30	S:S:L277	S:S:M54	10.1038	8.48	No	Yes	0	7	7
31	S:S:F55	S:S:R58	54.6902	4.28	Yes	Yes	2	6	9
32	R:R:C59	R:R:F99	98.9552	4.19	No	No	0	7	5
33	M:M:P11	S:S:T131	11.7617	6.99	Yes	Yes	0	0	6
34	M:M:P11	S:S:Y101	16.7729	12.52	Yes	Yes	2	0	6
35	S:S:L138	S:S:R58	17.8318	3.64	Yes	Yes	2	8	9
36	S:S:L283	S:S:R58	46.9192	7.29	No	Yes	0	8	9
37	R:R:L283	R:R:R58	58.2633	6.07	No	Yes	0	8	9
38	R:R:R58	R:R:S95	98.3953	3.95	Yes	No	0	9	8
39	R:R:C59	R:R:S95	98.5376	5.16	No	No	0	7	8
40	S:S:L283	S:S:L287	45.5452	6.92	No	No	0	8	8
41	S:S:L287	S:S:T65	45.1471	4.42	No	Yes	0	8	7
42	S:S:P290	S:S:T65	44.5286	3.5	No	Yes	0	9	7
43	S:S:N84	S:S:P290	38.8675	11.4	No	No	3	9	9
44	S:S:L289	S:S:N84	39.393	10.98	Yes	No	3	9	9
45	D:D:I471	S:S:L289	26.5951	4.28	No	Yes	3	6	9
46	D:D:I471	S:S:L247	26.4466	4.28	No	No	0	6	9
47	S:S:L226	S:S:L247	26.0485	5.54	No	No	0	9	9
48	S:S:F244	S:S:L226	27.6384	4.87	Yes	No	0	9	9
49	S:S:D242	S:S:F244	18.9673	3.58	No	Yes	8	8	9
50	S:S:D242	S:S:H245	18.5848	13.87	No	No	0	8	9
51	S:S:F241	S:S:H245	17.0177	6.79	No	No	0	9	9
52	S:S:F241	S:S:I246	16.4921	3.77	No	No	0	9	8
53	S:S:I246	S:S:W295	15.4364	15.27	No	No	0	8	9
54	R:R:M71	S:S:W295	14.3744	19.78	Yes	No	0	7	9
55	R:R:M71	R:R:V68	12.7697	3.04	Yes	Yes	0	7	7
56	R:R:M250	R:R:W295	10.591	3.49	No	Yes	0	9	9
57	R:R:M250	R:R:S292	13.2905	3.07	No	No	0	9	9
58	R:R:L289	R:R:S292	14.3588	4.5	Yes	No	0	9	9
59	R:R:L289	R:R:N84	49.0541	8.24	Yes	No	0	9	9
60	R:R:N84	R:R:P290	48.3769	11.4	No	No	4	9	9
61	R:R:P290	R:R:T65	55.5481	3.5	No	No	0	9	7
62	R:R:L287	R:R:T65	56.3317	4.42	No	No	0	8	7
63	R:R:L283	R:R:L287	56.7211	8.3	No	No	0	8	8
64	S:S:S108	S:S:T110	82.7391	6.4	No	Yes	0	7	7
65	R:R:Q42	S:S:S108	82.6891	12.99	Yes	No	0	7	7
66	M:M:P11	S:S:Y128	21.1874	4.17	Yes	Yes	0	0	8
67	S:S:N132	S:S:Y128	15.1909	12.79	No	Yes	0	7	8
68	M:M:M12	S:S:N132	14.5167	12.62	No	No	0	0	7
69	S:S:I142	S:S:L138	17.8818	4.28	No	Yes	0	8	8
70	S:S:E143	S:S:L146	17.2257	3.98	Yes	No	0	8	9
71	S:S:I142	S:S:L146	17.6644	2.85	No	No	0	8	9
72	S:S:E143	S:S:S214	14.6168	8.62	Yes	No	0	8	9
73	S:S:I150	S:S:M218	12.4201	4.37	Yes	Yes	12	8	8
74	S:S:M218	S:S:S214	14.1836	3.07	Yes	No	0	8	9
75	M:M:M12	S:S:S184	11.1228	7.67	No	No	0	0	5
76	S:S:S184	S:S:Y203	10.4393	2.54	No	No	0	5	5
77	M:M:Y13	S:S:D275	10.1773	3.45	Yes	No	0	0	5
78	R:R:F55	R:R:R58	29.0327	6.41	Yes	Yes	1	6	9
79	L:L:Y13	R:R:F55	16.5555	3.09	Yes	Yes	1	0	6
80	L:L:Y13	R:R:H94	16.862	4.36	Yes	Yes	1	0	8
81	R:R:H94	R:R:R58	32.8662	5.64	Yes	Yes	1	8	9
82	R:R:H94	R:R:Q135	10.8412	7.42	Yes	No	0	8	6
83	R:R:I150	R:R:M218	15.2393	7.29	Yes	Yes	14	8	8
84	R:R:F154	R:R:K225	24.7128	6.2	Yes	No	0	9	9
85	R:R:I153	R:R:K225	25.2133	4.36	No	No	0	8	9
86	R:R:I153	R:R:L222	25.7122	7.14	No	No	0	8	9
87	R:R:L222	R:R:Q149	34.4256	6.65	No	No	0	9	9
88	R:R:L289	R:R:Q149	34.8791	14.64	Yes	No	0	9	9
89	R:R:F154	R:R:V221	10.8084	3.93	Yes	No	0	9	7
90	L:L:H2	R:R:D275	10.1812	10.08	No	No	0	0	5
91	L:L:Y13	R:R:D275	10.9499	5.75	Yes	No	1	0	5
92	R:R:P19	S:S:F116	10.2641	8.67	Yes	Yes	5	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:Q51	S:S:S47	4.33	2	Yes	No	4	5	1	2
S:S:Q51	S:S:Y98	4.51	2	Yes	Yes	4	6	1	1
S:S:Q51	S:S:V276	8.6	2	Yes	Yes	4	5	1	1
M:M:Q10	S:S:Q51	3.84	2	Yes	Yes	0	4	0	1
S:S:M54	S:S:V276	6.09	0	Yes	Yes	7	5	2	1
S:S:F55	S:S:R58	4.28	2	Yes	Yes	6	9	2	2
S:S:F55	S:S:Y98	28.88	2	Yes	Yes	6	6	2	1
S:S:F55	S:S:T279	6.49	2	Yes	Yes	6	7	2	1
S:S:H94	S:S:R58	5.64	0	No	Yes	8	9	2	2
S:S:R58	S:S:T279	6.47	2	Yes	Yes	9	7	2	1
S:S:H94	S:S:T131	5.48	0	No	Yes	8	6	2	1
S:S:L97	S:S:T131	8.84	0	No	Yes	7	6	2	1
S:S:Y101	S:S:Y98	10.92	2	Yes	Yes	6	6	1	1
S:S:L102	S:S:Y98	7.03	2	No	Yes	7	6	2	1
M:M:Q10	S:S:Y98	6.76	2	Yes	Yes	0	6	0	1
M:M:P11	S:S:Y98	5.56	2	Yes	Yes	0	6	0	1
S:S:L102	S:S:Y101	3.52	2	No	Yes	7	6	2	1
M:M:K7	S:S:Y101	4.78	2	No	Yes	0	6	0	1
M:M:Q10	S:S:Y101	9.02	2	Yes	Yes	0	6	0	1
M:M:P11	S:S:Y101	12.52	2	Yes	Yes	0	6	0	1
S:S:Y106	S:S:Y111	5.96	11	Yes	No	5	5	1	1
S:S:I120	S:S:Y106	16.92	11	No	Yes	7	5	2	1
S:S:D124	S:S:Y106	3.45	0	No	Yes	6	5	2	1
M:M:G9	S:S:Y106	8.69	0	No	Yes	0	5	0	1
S:S:I120	S:S:Y111	12.09	11	No	No	7	5	2	1
M:M:P8	S:S:Y111	4.17	0	No	No	0	5	0	1
S:S:N132	S:S:Y128	12.79	0	No	Yes	7	8	1	1
S:S:T192	S:S:Y128	12.48	0	No	Yes	6	8	2	1
M:M:P11	S:S:Y128	4.17	2	Yes	Yes	0	8	0	1
M:M:P11	S:S:T131	6.99	2	Yes	Yes	0	6	0	1
M:M:M12	S:S:N132	12.62	0	No	No	0	7	0	1
M:M:M12	S:S:S184	7.67	0	No	No	0	5	0	1
S:S:D201	S:S:T199	8.67	0	No	No	2	1	1	2
S:S:F204	S:S:T208	7.78	2	No	No	5	6	1	2
M:M:L6	S:S:F204	10.96	2	No	No	0	5	0	1
M:M:Y13	S:S:F204	13.41	2	Yes	No	0	5	0	1
S:S:N205	S:S:Y266	5.81	13	No	Yes	6	6	1	1
M:M:W3	S:S:N205	7.91	0	No	No	0	6	0	1
M:M:L4	S:S:N205	5.49	13	No	No	0	6	0	1
S:S:F262	S:S:T208	3.89	2	Yes	No	7	6	2	2
S:S:T208	S:S:T278	3.14	2	No	Yes	6	5	2	1
S:S:I209	S:S:Y266	6.04	0	No	Yes	8	6	2	1
S:S:F262	S:S:T278	6.49	2	Yes	Yes	7	5	2	1
M:M:L4	S:S:Y266	17.58	13	No	Yes	0	6	0	1
M:M:W1	S:S:S267	6.18	0	No	No	0	4	0	1
S:S:K269	S:S:P270	3.35	0	No	No	2	2	2	1
S:S:N271	S:S:P270	6.52	0	No	No	4	2	2	1
M:M:H2	S:S:P270	15.25	0	No	No	0	2	0	1
M:M:H2	S:S:D275	8.82	0	No	No	0	5	0	1
M:M:L4	S:S:D275	5.43	13	No	No	0	5	0	1
M:M:Y13	S:S:D275	3.45	2	Yes	No	0	5	0	1
S:S:T279	S:S:V276	3.17	2	Yes	Yes	7	5	1	1
M:M:Y13	S:S:V276	10.09	2	Yes	Yes	0	5	0	1
M:M:Y13	S:S:T278	3.75	2	Yes	Yes	0	5	0	1
M:M:Y13	S:S:T279	6.24	2	Yes	Yes	0	7	0	1
S:S:G129	S:S:Y128	2.9	0	No	Yes	6	8	2	1
S:S:G188	S:S:Y128	2.9	0	No	Yes	8	8	2	1
M:M:L6	S:S:D201	2.71	2	No	No	0	2	0	1
M:M:Q5	S:S:D201	2.61	0	No	No	0	2	0	1
S:S:S184	S:S:Y203	2.54	0	No	No	5	5	1	2
M:M:W1	S:S:I263	2.35	0	No	No	0	7	0	1
M:M:W1	S:S:Y266	1.93	0	No	Yes	0	6	0	1
S:S:A185	S:S:V136	1.7	0	No	No	6	5	1	2
S:S:A265	S:S:T278	1.68	0	No	Yes	8	5	2	1
M:M:M12	S:S:A185	1.61	0	No	No	0	6	0	1
S:S:T131	S:S:V127	1.59	0	Yes	No	6	5	1	2
S:S:S104	S:S:Y101	1.27	0	No	Yes	6	6	2	1
S:S:S104	S:S:Y106	1.27	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q51	R:R:Y98	5.64	1	Yes	Yes	4	6	1	1
R:R:L102	R:R:Q51	3.99	1	No	Yes	7	4	2	1
R:R:Q51	R:R:V276	8.6	1	Yes	Yes	4	5	1	1
L:L:Q10	R:R:Q51	5.12	1	Yes	Yes	0	4	0	1
R:R:M54	R:R:V276	4.56	0	No	Yes	7	5	2	1
R:R:F55	R:R:R58	6.41	1	Yes	Yes	6	9	1	2
R:R:F55	R:R:H94	4.53	1	Yes	Yes	6	8	1	1
R:R:F55	R:R:Y98	24.76	1	Yes	Yes	6	6	1	1
R:R:F55	R:R:V276	3.93	1	Yes	Yes	6	5	1	1
R:R:F55	R:R:T279	7.78	1	Yes	No	6	7	1	2
L:L:Y13	R:R:F55	3.09	1	Yes	Yes	0	6	0	1
R:R:H94	R:R:R58	5.64	1	Yes	Yes	8	9	1	2
R:R:R58	R:R:T279	14.23	1	Yes	No	9	7	2	2
R:R:H94	R:R:T131	4.11	1	Yes	Yes	8	6	1	1
R:R:H94	R:R:Q135	7.42	1	Yes	No	8	6	1	1
L:L:Y13	R:R:H94	4.36	1	Yes	Yes	0	8	0	1
R:R:L97	R:R:T131	5.9	0	No	Yes	7	6	2	1
R:R:Y101	R:R:Y98	8.94	1	Yes	Yes	6	6	1	1
R:R:L102	R:R:Y98	4.69	1	No	Yes	7	6	2	1
L:L:Q10	R:R:Y98	4.51	1	Yes	Yes	0	6	0	1
L:L:P11	R:R:Y98	4.17	1	Yes	Yes	0	6	0	1
R:R:S107	R:R:Y101	5.09	0	No	Yes	5	6	2	1
L:L:Q10	R:R:Y101	7.89	1	Yes	Yes	0	6	0	1
L:L:P11	R:R:Y101	12.52	1	Yes	Yes	0	6	0	1
R:R:I120	R:R:Y106	14.51	0	No	No	7	5	2	1
R:R:D124	R:R:Y106	3.45	0	Yes	No	6	5	2	1
L:L:G9	R:R:Y106	5.79	0	No	No	0	5	0	1
R:R:I120	R:R:Y111	12.09	0	No	No	7	5	2	2
R:R:N132	R:R:Y128	6.98	0	No	Yes	7	8	1	1
R:R:T192	R:R:Y128	16.23	0	No	Yes	6	8	2	1
L:L:P11	R:R:Y128	4.17	1	Yes	Yes	0	8	0	1
L:L:P11	R:R:T131	8.74	1	Yes	Yes	0	6	0	1
R:R:M189	R:R:N132	4.21	0	No	No	5	7	2	1
L:L:M12	R:R:N132	8.41	0	Yes	No	0	7	0	1
R:R:Q135	R:R:Y181	6.76	0	No	Yes	6	7	1	2
L:L:M12	R:R:Q135	6.8	0	Yes	No	0	6	0	1
R:R:S207	R:R:Y181	15.26	0	No	Yes	6	7	2	2
R:R:S184	R:R:Y203	3.82	0	No	Yes	5	5	1	2
R:R:S184	R:R:S207	4.89	0	No	No	5	6	1	2
L:L:M12	R:R:S184	4.6	0	Yes	No	0	5	0	1
R:R:D201	R:R:N205	4.04	0	No	Yes	2	6	1	1
L:L:Q5	R:R:D201	6.53	0	No	No	0	2	0	1
L:L:L6	R:R:D201	4.07	1	Yes	No	0	2	0	1
L:L:W3	R:R:K202	10.44	0	No	No	0	3	0	1
R:R:F204	R:R:T208	7.78	1	Yes	Yes	5	6	1	1
L:L:L4	R:R:F204	3.65	1	Yes	Yes	0	5	0	1
L:L:L6	R:R:F204	15.83	1	Yes	Yes	0	5	0	1
L:L:M12	R:R:F204	7.46	0	Yes	Yes	0	5	0	1
L:L:Y13	R:R:F204	11.35	1	Yes	Yes	0	5	0	1
R:R:N205	R:R:Y266	3.49	1	Yes	Yes	6	6	1	1
L:L:W3	R:R:N205	13.56	0	No	Yes	0	6	0	1
L:L:L4	R:R:N205	5.49	1	Yes	Yes	0	6	0	1
R:R:T208	R:R:Y266	6.24	1	Yes	Yes	6	6	1	1
R:R:T208	R:R:T278	3.14	1	Yes	Yes	6	5	1	1
L:L:L4	R:R:T208	4.42	1	Yes	Yes	0	6	0	1
R:R:I209	R:R:Y266	6.04	0	No	Yes	8	6	2	1
R:R:F262	R:R:T278	6.49	0	No	Yes	7	5	2	1
L:L:L4	R:R:Y266	11.72	1	Yes	Yes	0	6	0	1
R:R:K269	R:R:P270	3.35	0	No	No	2	2	2	1
R:R:N271	R:R:P270	4.89	0	No	No	4	2	2	1
L:L:H2	R:R:P270	10.68	0	No	No	0	2	0	1
L:L:H2	R:R:D275	10.08	0	No	No	0	5	0	1
L:L:L4	R:R:D275	4.07	1	Yes	No	0	5	0	1
L:L:Y13	R:R:D275	5.75	1	Yes	No	0	5	0	1
L:L:Y13	R:R:V276	7.57	1	Yes	Yes	0	5	0	1
L:L:Y13	R:R:T278	4.99	1	Yes	Yes	0	5	0	1
L:L:L6	R:R:T199	2.95	1	Yes	No	0	1	0	1
R:R:D195	R:R:S197	2.94	0	No	No	3	3	2	1
R:R:S197	R:R:Y111	2.54	0	No	No	3	5	1	2
L:L:W1	R:R:S267	2.47	0	No	No	0	4	0	1
L:L:W1	R:R:Y266	1.93	0	No	Yes	0	6	0	1
L:L:P8	R:R:S197	1.78	0	No	No	0	3	0	1
R:R:A185	R:R:V136	1.7	0	No	No	6	5	1	2
R:R:A265	R:R:T278	1.68	0	No	Yes	8	5	2	1
R:R:G273	R:R:Q51	1.64	0	No	Yes	3	4	2	1
L:L:M12	R:R:A185	1.61	0	Yes	No	0	6	0	1
R:R:T131	R:R:V127	1.59	0	Yes	No	6	5	1	2
R:R:G188	R:R:Y128	1.45	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7AD3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	617
Number of Links	693
Number of Hubs	94
Number of Links mediated by Hubs	342
Number of Communities	16
Number of Nodes involved in Communities	106
Number of Links involved in Communities	150

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	257505
Length Of Smallest Path	3
Average Path Length	24.4766
Length of Longest Path	65
Minimum Path Strength	1.23
Average Path Strength	6.75486
Maximum Path Strength	19.9
Minimum Path Correlation	0.7
Average Path Correlation	0.95254
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.08333
Average % Of Corr. Nodes	41.8956
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6143
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of cellular process • response to stimulus • sexual reproduction • signaling • regulation of reproductive process • reproductive process • positive regulation of biological process • regulation of conjugation with cellular fusion • regulation of signal transduction • response to pheromone • cell communication • cellular response to pheromone • positive regulation of conjugation with cellular fusion • signal transduction • positive regulation of reproductive process • pheromone-dependent signal transduction involved in conjugation with cellular fusion • regulation of biological process • regulation of signaling • regulation of signal transduction involved in conjugation with cellular fusion • signal transduction involved in positive regulation of conjugation with cellular fusion • biological regulation • conjugation with cellular fusion • response to pheromone triggering conjugation with cellular fusion • cellular response to chemical stimulus • regulation of response to stimulus • regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion • response to chemical • regulation of cell communication • cellular process • G protein-coupled receptor signaling pathway • cell periphery • cell cortex • cellular anatomical structure • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex
Gene Ontology	Cellular Component	• cell periphery • cell cortex • cellular anatomical structure • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • Cdc24p-Far1p-Gbetagamma complex • G-protein beta/gamma-subunit complex • protein binding • binding • G-protein beta-subunit binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • carbohydrate metabolic process • regulation of biological process • regulation of cellular process • biological regulation • primary metabolic process • metabolic process • cellular process • regulation of carbohydrate metabolic process • regulation of metabolic process • regulation of primary metabolic process • cellular response to stimulus • sexual reproduction • response to stimulus • signaling • regulation of reproductive process • reproductive process • positive regulation of biological process • regulation of conjugation with cellular fusion • response to pheromone • cellular response to pheromone • cell communication • positive regulation of conjugation with cellular fusion • signal transduction • positive regulation of reproductive process • pheromone-dependent signal transduction involved in conjugation with cellular fusion • signal transduction involved in positive regulation of conjugation with cellular fusion • conjugation with cellular fusion • response to pheromone triggering conjugation with cellular fusion • cellular response to chemical stimulus • response to chemical • G protein-coupled receptor signaling pathway • establishment of organelle localization • cellular localization • organelle transport along microtubule • transport • nuclear migration involved in conjugation with cellular fusion • nucleus localization • intracellular transport • establishment of localization • localization • organelle localization • establishment of localization in cell • nuclear migration along microtubule • microtubule-based transport • transport along microtubule • cytoskeleton-dependent intracellular transport • microtubule-based movement • microtubule-based process • nuclear migration • organelle fusion • cellular component organization • organelle organization • nucleus organization • karyogamy • karyogamy involved in conjugation with cellular fusion • cellular component organization or biogenesis • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • cytosol • endosome membrane • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • organelle membrane • G-protein gamma-subunit binding • small GTPase binding • enzyme binding • GTPase binding • scaffold protein binding • kinase binding • protein kinase binding • G-protein alpha-subunit binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • regulation of signal transduction • regulation of signaling • regulation of signal transduction involved in conjugation with cellular fusion • regulation of response to stimulus • regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion • regulation of cell communication • invasive growth in response to glucose limitation • growth • invasive filamentous growth • growth of unicellular organism as a thread of attached cells • filamentous growth • filamentous growth of a population of unicellular organisms • protein localization to cell tip • protein localization to mating projection tip • macromolecule localization • intracellular protein localization • chemotropism • tropism • response to external stimulus • establishment of protein localization • establishment of protein localization to membrane • establishment of protein localization to plasma membrane • localization within membrane • cell projection • mating projection • plasma membrane bounded cell projection • cupric ion binding • transition metal ion binding • copper ion binding • pheromone activity • molecular function activator activity • mating pheromone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • mating • multi-organism reproductive process • extracellular region • peptide pheromone receptor activity • peptide receptor activity • molecular transducer activity • mating-type factor pheromone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • mating-type alpha-factor pheromone receptor activity • pheromone receptor activity • reproductive process in single-celled organism • cytogamy • G protein-coupled receptor homodimeric complex • receptor complex • G protein-coupled receptor dimeric complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	S
Protein	Receptor
UniProt	P0CI39
Sequence	>7AD3_nogp_Chain_S M S D A A P S L S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I T F D E L Q G L V N S T V T Q A I M F G V R C G A A A L T L I V M W M T S R S R K T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S N Y S S V T Y A L T G F P Q F I S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T G D N F K R I G L M L T S I S F T L G I A T V T M Y F V S A V K G M I V T Y N D V S A T Q D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L G L K Q F D S F H I L L I M S C Q S L L V P S I I F I L A Y S L K P N Q G T D V L T T V A T L L A V L S L P L S S M W A T A A N N A S K T N T I T S D F T T S T D R F Y P G T L S S F Q T D S I N N D A K S S L R S R L Y D L Y P R R K E T T S D K H S E R T F V S E T A D D I E K N Q F Y Q L P T P T S S K N T R I G P F A D A S Y K E G E V E P V D M Y T P D T A A D E E A R K F W T E D N N N L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P0CI39
Sequence	>7AD3_nogp_Chain_R S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I T F D E L Q G L V N S T V T Q A I M F G V R C G A A A L T L I V M W M T S R S R K T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S N Y S S V T Y A L T G F P Q F I S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T G D N F K R I G L M L T S I S F T L G I A T V T M Y F V S A V K G M I V T Y N D V S A T Q D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L G L K Q F D S F H I L L I M S C Q S L L V P S I I F I L A Y S L K P N Q G T D V L T T V A T L L A V L S L P L S S M W A T A A N N A S K T N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	D
Protein	G Protein α Sub unit
UniProt	P08539
Sequence	>7AD3_nogp_Chain_D T Q T I G D E S D P F L Q N K R A N D V I E Q S L Q L E K Q R D K N E I K L L L L G A D N S G K S T V L K Q L K T G I T E T E F N I G S S K F K V L D A G G Q R S E R K K W I H C F E G I T A V L F V L D M S D Y N R M H E S I M L F D T L L N S K W F K D T P F I L F L N K I D L F E E K V K S M P I R K Y F P D G R V G D A E A G L K Y F E K I F L S L N K T N K P I Y V K R T C A T D T Q T A K F I L S A V T D L I I Q Q N L K K I G I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3

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