psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:L11	S:S:N10	13.73	No	No	0	3	4
2	S:S:L11	S:S:Y17	3.52	No	Yes	0	3	7
3	R:R:I29	S:S:F12	7.54	Yes	No	0	4	1
4	R:R:P117	S:S:F12	4.33	No	No	0	4	1
5	S:S:P19	S:S:Y17	5.56	Yes	Yes	6	7	7
6	R:R:F116	S:S:Y17	8.25	Yes	Yes	6	7	7
7	R:R:Q118	S:S:Y17	7.89	No	Yes	6	7	7
8	R:R:T110	S:S:P19	3.5	Yes	Yes	0	7	7
9	R:R:F116	S:S:P19	10.11	Yes	Yes	6	7	7
10	S:S:F38	S:S:S22	5.28	Yes	No	0	7	9
11	R:R:T27	S:S:S22	3.2	No	No	0	5	9
12	S:S:T23	S:S:T35	3.14	No	No	7	5	4
13	S:S:F38	S:S:I24	15.07	Yes	No	0	7	6
14	S:S:S28	S:S:Y26	5.09	No	Yes	8	4	6
15	S:S:S34	S:S:Y26	5.09	Yes	Yes	8	6	6
16	S:S:I36	S:S:Y26	3.63	No	Yes	0	6	6
17	S:S:L113	S:S:Y26	12.89	No	Yes	0	7	6
18	R:R:S22	S:S:T27	3.2	No	No	0	9	5
19	S:S:S28	S:S:S34	4.89	No	Yes	8	4	6
20	S:S:S28	S:S:T114	3.2	No	No	0	4	7
21	S:S:G115	S:S:I29	3.53	No	No	0	2	4
22	S:S:F116	S:S:I29	5.02	Yes	No	0	7	4
23	R:R:F12	S:S:I29	7.54	No	No	0	1	4
24	S:S:E40	S:S:I36	4.1	No	No	0	3	6
25	S:S:E40	S:S:T37	8.47	No	No	0	3	6
26	R:R:Y26	S:S:F38	4.13	Yes	Yes	0	6	7
27	R:R:T110	S:S:F38	5.19	Yes	Yes	0	7	7
28	S:S:Q42	S:S:V45	5.73	Yes	No	0	7	4
29	S:S:N46	S:S:Q42	11.88	No	Yes	0	5	7
30	R:R:S108	S:S:Q42	5.78	No	Yes	0	7	7
31	R:R:V109	S:S:Q42	4.3	No	Yes	0	5	7
32	R:R:V45	S:S:V45	8.02	No	No	0	4	4
33	R:R:L103	S:S:N46	4.12	No	No	0	7	5
34	S:S:Q51	S:S:S47	4.33	Yes	No	0	4	5
35	S:S:G273	S:S:S47	3.71	No	No	0	3	5
36	S:S:S107	S:S:T48	3.2	No	No	0	5	4
37	R:R:V49	S:S:T48	3.17	No	No	0	6	4
38	S:S:I53	S:S:V49	3.07	No	No	0	7	6
39	R:R:L103	S:S:V49	4.47	No	No	0	7	6
40	S:S:Q51	S:S:Y98	4.51	Yes	Yes	2	4	6
41	S:S:Q51	S:S:V276	8.6	Yes	Yes	2	4	5
42	M:M:Q10	S:S:Q51	3.84	Yes	Yes	2	0	4
43	R:R:I53	S:S:A52	3.25	No	No	0	7	6
44	R:R:A52	S:S:I53	3.25	No	No	0	6	7
45	R:R:F99	S:S:I53	18.84	No	No	0	5	7
46	S:S:M54	S:S:V276	6.09	Yes	Yes	0	7	5
47	S:S:L277	S:S:M54	8.48	No	Yes	0	7	7
48	S:S:M54	S:S:V280	4.56	Yes	No	0	7	7
49	S:S:F55	S:S:R58	4.28	Yes	Yes	2	6	9
50	S:S:F55	S:S:Y98	28.88	Yes	Yes	2	6	6
51	S:S:F55	S:S:F99	3.22	Yes	Yes	0	6	5
52	S:S:F55	S:S:T279	6.49	Yes	Yes	2	6	7
53	R:R:G60	S:S:V57	5.52	No	No	0	9	6
54	S:S:I91	S:S:R58	5.01	Yes	Yes	2	7	9
55	S:S:H94	S:S:R58	5.64	No	Yes	0	8	9
56	S:S:R58	S:S:S95	5.27	Yes	No	0	9	8
57	S:S:L138	S:S:R58	3.64	Yes	Yes	2	8	9
58	S:S:R58	S:S:T279	6.47	Yes	Yes	2	9	7
59	S:S:L283	S:S:R58	7.29	No	Yes	0	8	9
60	S:S:C59	S:S:S95	3.44	No	No	0	7	8
61	S:S:C59	S:S:F99	5.59	No	Yes	0	7	5
62	S:S:A61	S:S:L283	3.15	No	No	0	8	8
63	R:R:L64	S:S:A61	3.15	No	No	0	5	8
64	S:S:A62	S:S:I91	3.25	No	Yes	0	8	7
65	S:S:A62	S:S:I92	3.25	No	No	0	8	5
66	S:S:A63	S:S:I92	3.25	No	No	0	4	5
67	S:S:I67	S:S:L64	4.28	No	No	0	5	5
68	R:R:A61	S:S:L64	3.15	No	No	0	8	5
69	S:S:L88	S:S:T65	4.42	No	Yes	0	9	7
70	S:S:L287	S:S:T65	4.42	No	Yes	0	8	7
71	S:S:P290	S:S:T65	3.5	No	Yes	0	9	7
72	R:R:L64	S:S:T65	5.9	No	Yes	0	5	7
73	S:S:L66	S:S:W70	4.56	No	No	3	5	4
74	S:S:L66	S:S:Q85	6.65	No	No	3	5	5
75	S:S:T72	S:S:V68	4.76	No	No	0	7	7
76	S:S:M294	S:S:V68	6.09	No	No	0	8	7
77	S:S:F81	S:S:M69	3.73	Yes	No	3	9	8
78	S:S:M69	S:S:N84	5.61	No	No	3	8	9
79	S:S:M69	S:S:P290	6.71	No	No	3	8	9
80	S:S:R76	S:S:W70	4	No	No	3	6	4
81	S:S:Q85	S:S:W70	17.52	No	No	3	5	4
82	R:R:L291	S:S:M71	4.24	No	No	0	8	7
83	R:R:W295	S:S:M71	13.96	Yes	No	0	9	7
84	R:R:A298	S:S:T72	5.03	No	No	0	7	7
85	S:S:R76	S:S:S73	5.27	No	No	3	6	8
86	S:S:F81	S:S:S73	5.28	Yes	No	3	9	8
87	S:S:R74	S:S:T297	6.47	Yes	No	0	6	6
88	S:S:N301	S:S:R74	7.23	Yes	Yes	9	6	6
89	R:R:N301	S:S:R74	8.44	Yes	Yes	9	6	6
90	R:R:N306	S:S:R74	4.82	No	Yes	0	5	6
91	S:S:F81	S:S:R76	7.48	Yes	No	3	9	6
92	S:S:P79	S:S:T78	3.5	No	No	0	4	8
93	S:S:I80	S:S:L289	4.28	No	No	0	7	9
94	S:S:F81	S:S:Q85	14.05	Yes	No	3	9	5
95	S:S:F148	S:S:I83	5.02	No	No	0	7	7
96	S:S:L289	S:S:N84	10.98	No	No	0	9	9
97	S:S:N84	S:S:P290	11.4	No	No	3	9	9
98	S:S:S141	S:S:S87	6.52	No	No	0	6	8
99	S:S:I91	S:S:L138	5.71	Yes	Yes	2	7	8
100	S:S:I91	S:S:V286	4.61	Yes	No	0	7	8
101	S:S:I134	S:S:L93	5.71	No	No	0	5	6
102	S:S:H94	S:S:T131	5.48	No	Yes	0	8	6
103	S:S:H94	S:S:Q135	7.42	No	No	0	8	6
104	S:S:L97	S:S:T131	8.84	No	Yes	0	7	6
105	S:S:Y101	S:S:Y98	10.92	Yes	Yes	2	6	6
106	S:S:L102	S:S:Y98	7.03	No	Yes	2	7	6
107	M:M:Q10	S:S:Y98	6.76	Yes	Yes	2	0	6
108	M:M:P11	S:S:Y98	5.56	Yes	Yes	2	0	6
109	R:R:I53	S:S:F99	17.58	No	Yes	0	7	5
110	S:S:L102	S:S:Y101	3.52	No	Yes	2	7	6
111	M:M:K7	S:S:Y101	4.78	No	Yes	2	0	6
112	M:M:Q10	S:S:Y101	9.02	Yes	Yes	2	0	6
113	M:M:P11	S:S:Y101	12.52	Yes	Yes	2	0	6
114	R:R:N46	S:S:L103	5.49	No	No	0	5	7
115	R:R:V49	S:S:L103	4.47	No	No	0	6	7
116	R:R:T50	S:S:L103	4.42	No	No	0	4	7
117	S:S:F119	S:S:N105	16.92	No	No	0	3	3
118	S:S:D124	S:S:N105	5.39	No	No	0	6	3
119	S:S:Y106	S:S:Y111	5.96	Yes	No	10	5	5
120	S:S:I120	S:S:Y106	16.92	No	Yes	10	7	5
121	S:S:D124	S:S:Y106	3.45	No	Yes	0	6	5
122	M:M:G9	S:S:Y106	8.69	No	Yes	0	0	5
123	S:S:S108	S:S:T110	6.4	No	Yes	0	7	7
124	R:R:Q42	S:S:S108	12.99	Yes	No	0	7	7
125	R:R:Q42	S:S:V109	4.3	Yes	No	0	7	5
126	S:S:F119	S:S:T110	14.27	No	Yes	5	3	7
127	R:R:P19	S:S:T110	3.5	Yes	Yes	5	7	7
128	R:R:F38	S:S:T110	11.67	Yes	Yes	0	7	7
129	S:S:I120	S:S:Y111	12.09	No	No	10	7	5
130	M:M:P8	S:S:Y111	4.17	No	No	0	0	5
131	S:S:F116	S:S:T114	5.19	Yes	No	0	7	7
132	R:R:F38	S:S:T114	3.89	Yes	No	0	7	7
133	R:R:L11	S:S:F116	4.87	Yes	Yes	5	3	7
134	R:R:Y17	S:S:F116	15.47	No	Yes	5	7	7
135	R:R:P19	S:S:F116	8.67	Yes	Yes	5	7	7
136	R:R:F12	S:S:P117	7.22	No	No	0	1	4
137	R:R:P19	S:S:F119	5.78	Yes	No	5	7	3
138	S:S:R122	S:S:V125	10.46	No	No	0	1	4
139	S:S:R122	S:S:Y193	4.12	No	No	0	1	5
140	S:S:N132	S:S:Y128	12.79	No	Yes	0	7	8
141	S:S:T192	S:S:Y128	12.48	No	Yes	0	6	8
142	M:M:P11	S:S:Y128	4.17	Yes	Yes	0	0	8
143	S:S:G129	S:S:M189	3.49	No	No	0	6	5
144	M:M:P11	S:S:T131	6.99	Yes	Yes	0	0	6
145	M:M:M12	S:S:N132	12.62	No	No	0	0	7
146	S:S:L138	S:S:Q135	5.32	Yes	No	0	8	6
147	S:S:Q135	S:S:Y181	4.51	No	Yes	0	6	7
148	S:S:I142	S:S:L138	4.28	No	Yes	0	8	8
149	S:S:V139	S:S:Y181	17.66	No	Yes	0	6	7
150	S:S:A140	S:S:V178	3.39	No	No	0	4	6
151	S:S:I142	S:S:V286	3.07	No	No	0	8	8
152	S:S:E143	S:S:L146	3.98	Yes	No	0	8	9
153	S:S:E143	S:S:G174	6.55	Yes	No	0	8	8
154	S:S:E143	S:S:T177	5.64	Yes	No	0	8	8
155	S:S:E143	S:S:S214	8.62	Yes	No	0	8	9
156	S:S:Q149	S:S:S145	4.33	No	No	0	9	9
157	S:S:L222	S:S:Q149	5.32	No	No	0	9	9
158	S:S:L289	S:S:Q149	11.98	No	No	0	9	9
159	S:S:I150	S:S:T167	4.56	Yes	No	0	8	7
160	S:S:I150	S:S:S170	9.29	Yes	No	11	8	8
161	S:S:I150	S:S:M218	4.37	Yes	Yes	11	8	8
162	S:S:I150	S:S:V221	4.61	Yes	No	0	8	7
163	S:S:I153	S:S:K225	4.36	No	No	0	8	9
164	S:S:F154	S:S:G163	4.52	Yes	No	0	9	7
165	S:S:F154	S:S:L166	7.31	Yes	No	0	9	7
166	S:S:F154	S:S:T167	5.19	Yes	No	0	9	7
167	S:S:F154	S:S:K225	8.69	Yes	No	0	9	9
168	S:S:D157	S:S:K160	9.68	No	No	0	6	5
169	S:S:M165	S:S:S168	3.07	No	No	0	2	3
170	S:S:I169	S:S:M165	5.83	No	No	0	4	2
171	S:S:F217	S:S:I169	5.02	No	No	0	6	4
172	S:S:M218	S:S:S170	9.2	Yes	No	11	8	8
173	S:S:F217	S:S:L173	4.87	No	No	0	6	7
174	S:S:S207	S:S:Y181	11.45	No	Yes	0	6	7
175	S:S:L211	S:S:Y181	7.03	No	Yes	0	6	7
176	S:S:F182	S:S:V186	3.93	No	No	0	5	8
177	M:M:M12	S:S:S184	7.67	No	No	0	0	5
178	S:S:K187	S:S:V191	4.55	No	No	0	3	3
179	S:S:K187	S:S:Q200	6.78	No	No	0	3	2
180	S:S:D195	S:S:S197	8.83	No	No	0	3	3
181	S:S:A198	S:S:D195	4.63	No	No	0	1	3
182	S:S:D201	S:S:T199	8.67	No	No	0	2	1
183	S:S:K202	S:S:Q200	4.07	No	No	0	3	2
184	S:S:Q200	S:S:Y203	11.27	No	No	0	2	5
185	S:S:F204	S:S:T208	7.78	No	No	2	5	6
186	M:M:L6	S:S:F204	10.96	No	No	2	0	5
187	M:M:Y13	S:S:F204	13.41	Yes	No	2	0	5
188	S:S:N205	S:S:Y266	5.81	No	Yes	12	6	6
189	M:M:W3	S:S:N205	7.91	No	No	0	0	6
190	M:M:L4	S:S:N205	5.49	No	No	12	0	6
191	S:S:F262	S:S:T208	3.89	Yes	No	2	7	6
192	S:S:T208	S:S:T278	3.14	No	Yes	2	6	5
193	S:S:I209	S:S:Y266	6.04	No	Yes	0	8	6
194	S:S:I215	S:S:L211	4.28	No	No	0	8	6
195	S:S:A212	S:S:F262	9.71	No	Yes	0	7	7
196	S:S:M218	S:S:S214	3.07	Yes	No	0	8	9
197	S:S:A285	S:S:I215	4.87	No	No	0	9	8
198	S:S:N216	S:S:S259	8.94	No	No	0	7	8
199	S:S:F217	S:S:V221	5.24	No	No	0	6	7
200	S:S:S219	S:S:S254	4.89	No	No	0	9	9
201	S:S:L255	S:S:S219	6.01	No	No	0	9	9
202	S:S:F220	S:S:L255	9.74	No	No	0	4	9
203	S:S:F244	S:S:L226	4.87	Yes	No	0	9	9
204	S:S:L226	S:S:L247	5.54	No	No	0	9	9
205	S:S:H245	S:S:I230	5.3	No	No	0	9	9
206	S:S:L238	S:S:R233	12.15	No	No	0	8	9
207	S:S:D242	S:S:R233	7.15	No	No	13	8	9
208	S:S:F244	S:S:R233	7.48	Yes	No	13	9	9
209	S:S:K239	S:S:R234	6.19	No	No	0	6	8
210	S:S:G237	S:S:L238	3.42	No	No	0	9	8
211	S:S:F241	S:S:H245	6.79	No	No	0	9	9
212	S:S:F241	S:S:I246	3.77	No	No	0	9	8
213	S:S:D242	S:S:F244	3.58	No	Yes	13	8	9
214	S:S:D242	S:S:H245	13.87	No	No	0	8	9
215	S:S:F244	S:S:S243	3.96	Yes	No	0	9	7
216	S:S:I246	S:S:W295	15.27	No	No	0	8	9
217	S:S:I249	S:S:W295	4.7	No	No	0	9	9
218	S:S:M250	S:S:Q253	4.08	No	No	0	9	9
219	S:S:M250	S:S:S292	4.6	No	No	0	9	9
220	S:S:Q253	S:S:V257	8.6	No	No	0	9	7
221	S:S:L284	S:S:Q253	3.99	No	No	0	6	9
222	S:S:S254	S:S:S288	6.52	No	No	0	9	8
223	S:S:P258	S:S:V257	3.53	No	No	0	9	7
224	S:S:I261	S:S:V257	3.07	No	No	0	7	7
225	S:S:I261	S:S:L277	4.28	No	No	0	7	7
226	S:S:A281	S:S:I261	4.87	No	No	0	7	7
227	S:S:F262	S:S:T278	6.49	Yes	Yes	2	7	5
228	S:S:A281	S:S:F262	5.55	No	Yes	0	7	7
229	M:M:L4	S:S:Y266	17.58	No	Yes	12	0	6
230	M:M:W1	S:S:S267	6.18	No	No	0	0	4
231	S:S:L268	S:S:T274	4.42	No	No	0	4	6
232	S:S:K269	S:S:P270	3.35	No	No	0	2	2
233	S:S:K269	S:S:Q272	4.07	No	No	0	2	1
234	S:S:N271	S:S:P270	6.52	No	No	0	4	2
235	M:M:H2	S:S:P270	15.25	No	No	0	0	2
236	S:S:Q272	S:S:T274	12.76	No	No	0	1	6
237	M:M:H2	S:S:D275	8.82	No	No	0	0	5
238	M:M:L4	S:S:D275	5.43	No	No	0	0	5
239	M:M:Y13	S:S:D275	3.45	Yes	No	0	0	5
240	S:S:T279	S:S:V276	3.17	Yes	Yes	2	7	5
241	M:M:Y13	S:S:V276	10.09	Yes	Yes	2	0	5
242	M:M:Y13	S:S:T278	3.75	Yes	Yes	2	0	5
243	M:M:Y13	S:S:T279	6.24	Yes	Yes	2	0	7
244	S:S:L283	S:S:L287	6.92	No	No	0	8	8
245	R:R:M71	S:S:L291	7.07	Yes	No	0	7	8
246	R:R:M71	S:S:W295	19.78	Yes	No	0	7	9
247	R:R:T72	S:S:A298	3.36	No	No	0	7	7
248	S:S:K304	S:S:N300	4.2	No	No	0	4	7
249	R:R:R74	S:S:N301	14.46	No	Yes	0	6	6
250	R:R:N301	S:S:N301	9.54	Yes	Yes	9	6	6
251	R:R:L11	R:R:N10	5.49	Yes	No	0	3	4
252	R:R:D14	R:R:L11	5.43	No	Yes	0	6	3
253	R:R:L11	R:R:Y17	5.86	Yes	No	5	3	7
254	R:R:D14	R:R:P15	4.83	No	No	0	6	5
255	R:R:S22	R:R:Y17	3.82	No	No	0	9	7
256	R:R:F38	R:R:S22	3.96	Yes	No	0	7	9
257	R:R:T23	R:R:T35	3.14	No	No	0	5	4
258	R:R:I24	R:R:Y26	4.84	No	Yes	0	6	6
259	R:R:F38	R:R:I24	10.05	Yes	No	0	7	6
260	R:R:S34	R:R:Y26	7.63	No	Yes	0	6	6
261	R:R:I36	R:R:Y26	4.84	No	Yes	0	6	6
262	R:R:L113	R:R:Y26	10.55	No	Yes	0	7	6
263	R:R:S28	R:R:S34	6.52	No	No	0	4	6
264	R:R:I29	R:R:Y30	6.04	Yes	No	0	4	7
265	R:R:G115	R:R:I29	5.29	No	Yes	0	2	4
266	R:R:F116	R:R:I29	7.54	Yes	Yes	0	7	4
267	R:R:E40	R:R:I36	5.47	No	No	0	3	6
268	R:R:Q42	R:R:V45	5.73	Yes	No	0	7	4
269	R:R:N46	R:R:Q42	11.88	No	Yes	0	5	7
270	R:R:S47	R:R:T48	3.2	No	No	0	5	4
271	R:R:Q51	R:R:Y98	5.64	Yes	Yes	1	4	6
272	R:R:L102	R:R:Q51	3.99	No	Yes	1	7	4
273	R:R:Q51	R:R:V276	8.6	Yes	Yes	1	4	5
274	L:L:Q10	R:R:Q51	5.12	Yes	Yes	1	0	4
275	R:R:M54	R:R:V276	4.56	No	Yes	0	7	5
276	R:R:L277	R:R:M54	8.48	No	No	0	7	7
277	R:R:F55	R:R:R58	6.41	Yes	Yes	1	6	9
278	R:R:F55	R:R:H94	4.53	Yes	Yes	1	6	8
279	R:R:F55	R:R:Y98	24.76	Yes	Yes	1	6	6
280	R:R:F55	R:R:V276	3.93	Yes	Yes	1	6	5
281	R:R:F55	R:R:T279	7.78	Yes	No	1	6	7
282	L:L:Y13	R:R:F55	3.09	Yes	Yes	1	0	6
283	R:R:I91	R:R:R58	10.02	Yes	Yes	1	7	9
284	R:R:H94	R:R:R58	5.64	Yes	Yes	1	8	9
285	R:R:R58	R:R:S95	3.95	Yes	No	0	9	8
286	R:R:L138	R:R:R58	3.64	Yes	Yes	1	8	9
287	R:R:R58	R:R:T279	14.23	Yes	No	1	9	7
288	R:R:L283	R:R:R58	6.07	No	Yes	0	8	9
289	R:R:C59	R:R:S95	5.16	No	No	0	7	8
290	R:R:C59	R:R:F99	4.19	No	No	0	7	5
291	R:R:A61	R:R:L283	3.15	No	No	0	8	8
292	R:R:A62	R:R:I91	3.25	No	Yes	0	8	7
293	R:R:A62	R:R:I92	3.25	No	No	0	8	5
294	R:R:A63	R:R:I92	3.25	No	No	0	4	5
295	R:R:L88	R:R:T65	5.9	No	No	0	9	7
296	R:R:L287	R:R:T65	4.42	No	No	0	8	7
297	R:R:P290	R:R:T65	3.5	No	No	0	9	7
298	R:R:L66	R:R:W70	3.42	No	Yes	4	5	4
299	R:R:L66	R:R:Q85	10.65	No	No	4	5	5
300	R:R:T72	R:R:V68	3.17	No	Yes	0	7	7
301	R:R:M294	R:R:V68	4.56	No	Yes	0	8	7
302	R:R:M69	R:R:S73	4.6	Yes	No	4	8	8
303	R:R:F81	R:R:M69	3.73	Yes	Yes	4	9	8
304	R:R:M69	R:R:N84	5.61	Yes	No	4	8	9
305	R:R:M69	R:R:P290	5.03	Yes	No	4	8	9
306	R:R:R76	R:R:W70	4	No	Yes	4	6	4
307	R:R:F81	R:R:W70	4.01	Yes	Yes	4	9	4
308	R:R:Q85	R:R:W70	18.62	No	Yes	4	5	4
309	R:R:R74	R:R:T72	5.17	No	No	0	6	7
310	R:R:F81	R:R:S73	5.28	Yes	No	4	9	8
311	R:R:R74	R:R:T297	14.23	No	No	0	6	6
312	R:R:S75	R:R:T78	4.8	No	No	0	5	8
313	R:R:F81	R:R:R76	9.62	Yes	No	4	9	6
314	R:R:F81	R:R:T78	3.89	Yes	No	0	9	8
315	R:R:I80	R:R:L289	4.28	No	Yes	0	7	9
316	R:R:F81	R:R:Q85	11.71	Yes	No	4	9	5
317	R:R:I83	R:R:S145	3.1	No	No	0	7	9
318	R:R:F148	R:R:I83	3.77	No	No	0	7	7
319	R:R:L289	R:R:N84	8.24	Yes	No	0	9	9
320	R:R:N84	R:R:P290	11.4	No	No	4	9	9
321	R:R:S141	R:R:S87	6.52	No	No	0	6	8
322	R:R:I142	R:R:S87	3.1	Yes	No	1	8	8
323	R:R:S87	R:R:V286	4.85	No	No	1	8	8
324	R:R:I134	R:R:L90	4.28	No	Yes	0	5	4
325	R:R:I91	R:R:L138	4.28	Yes	Yes	1	7	8
326	R:R:I91	R:R:V286	4.61	Yes	No	1	7	8
327	R:R:I134	R:R:L93	4.28	No	No	0	5	6
328	R:R:H94	R:R:T131	4.11	Yes	Yes	0	8	6
329	R:R:H94	R:R:Q135	7.42	Yes	No	0	8	6
330	L:L:Y13	R:R:H94	4.36	Yes	Yes	1	0	8
331	R:R:A130	R:R:L97	3.15	No	No	0	7	7
332	R:R:L97	R:R:T131	5.9	No	Yes	0	7	6
333	R:R:Y101	R:R:Y98	8.94	Yes	Yes	1	6	6
334	R:R:L102	R:R:Y98	4.69	No	Yes	1	7	6
335	L:L:Q10	R:R:Y98	4.51	Yes	Yes	1	0	6
336	L:L:P11	R:R:Y98	4.17	Yes	Yes	1	0	6
337	R:R:S107	R:R:Y101	5.09	No	Yes	0	5	6
338	L:L:Q10	R:R:Y101	7.89	Yes	Yes	1	0	6
339	L:L:P11	R:R:Y101	12.52	Yes	Yes	1	0	6
340	R:R:F119	R:R:N105	18.12	No	No	0	3	3
341	R:R:D124	R:R:N105	6.73	Yes	No	0	6	3
342	R:R:I120	R:R:Y106	14.51	No	No	0	7	5
343	R:R:D124	R:R:Y106	3.45	Yes	No	0	6	5
344	L:L:G9	R:R:Y106	5.79	No	No	0	0	5
345	R:R:S108	R:R:T110	3.2	No	Yes	0	7	7
346	R:R:F119	R:R:T110	7.78	No	Yes	0	3	7
347	R:R:I120	R:R:Y111	12.09	No	No	0	7	5
348	R:R:F116	R:R:T114	7.78	Yes	No	0	7	7
349	R:R:F116	R:R:Q118	9.37	Yes	No	6	7	7
350	R:R:I120	R:R:V196	6.14	No	No	0	7	1
351	R:R:D124	R:R:S121	10.31	Yes	No	0	6	4
352	R:R:R122	R:R:V125	7.85	No	No	0	1	4
353	R:R:R122	R:R:Y193	3.09	No	No	0	1	5
354	R:R:G123	R:R:H126	4.77	No	No	0	5	6
355	R:R:N132	R:R:Y128	6.98	No	Yes	0	7	8
356	R:R:T192	R:R:Y128	16.23	No	Yes	0	6	8
357	L:L:P11	R:R:Y128	4.17	Yes	Yes	0	0	8
358	R:R:G129	R:R:M189	3.49	No	No	0	6	5
359	L:L:P11	R:R:T131	8.74	Yes	Yes	0	0	6
360	R:R:M189	R:R:N132	4.21	No	No	0	5	7
361	L:L:M12	R:R:N132	8.41	Yes	No	0	0	7
362	R:R:Q135	R:R:Y181	6.76	No	Yes	0	6	7
363	L:L:M12	R:R:Q135	6.8	Yes	No	0	0	6
364	R:R:F182	R:R:V136	3.93	No	No	0	5	5
365	R:R:I142	R:R:L138	4.28	Yes	Yes	1	8	8
366	R:R:V139	R:R:Y181	16.4	No	Yes	0	6	7
367	R:R:A140	R:R:V178	3.39	No	No	0	4	6
368	R:R:I142	R:R:V286	3.07	Yes	No	1	8	8
369	R:R:E143	R:R:G174	6.55	Yes	No	0	8	8
370	R:R:E143	R:R:T177	7.06	Yes	No	0	8	8
371	R:R:E143	R:R:S214	8.62	Yes	No	0	8	9
372	R:R:L146	R:R:M218	5.65	No	Yes	0	9	8
373	R:R:F171	R:R:V147	3.93	No	No	0	3	7
374	R:R:L222	R:R:Q149	6.65	No	No	0	9	9
375	R:R:L289	R:R:Q149	14.64	Yes	No	0	9	9
376	R:R:I150	R:R:T167	4.56	Yes	No	0	8	7
377	R:R:I150	R:R:S170	7.74	Yes	No	14	8	8
378	R:R:I150	R:R:M218	7.29	Yes	Yes	14	8	8
379	R:R:I150	R:R:V221	7.68	Yes	No	0	8	7
380	R:R:I153	R:R:L222	7.14	No	No	0	8	9
381	R:R:I153	R:R:K225	4.36	No	No	0	8	9
382	R:R:F154	R:R:G163	9.03	Yes	No	0	9	7
383	R:R:F154	R:R:L166	7.31	Yes	No	0	9	7
384	R:R:F154	R:R:T167	5.19	Yes	No	0	9	7
385	R:R:F154	R:R:V221	3.93	Yes	No	0	9	7
386	R:R:F154	R:R:K225	6.2	Yes	No	0	9	9
387	R:R:F217	R:R:L166	3.65	Yes	No	0	6	7
388	R:R:F217	R:R:I169	6.28	Yes	No	0	6	4
389	R:R:M218	R:R:S170	7.67	Yes	No	14	8	8
390	R:R:F171	R:R:I175	5.02	No	No	0	3	4
391	R:R:F217	R:R:L173	3.65	Yes	No	0	6	7
392	R:R:L210	R:R:T177	7.37	No	No	0	6	8
393	R:R:M180	R:R:Y203	4.79	No	Yes	0	6	5
394	R:R:S207	R:R:Y181	15.26	No	Yes	0	6	7
395	R:R:L211	R:R:Y181	7.03	No	Yes	0	6	7
396	R:R:F182	R:R:V186	5.24	No	No	0	5	8
397	R:R:V183	R:R:Y203	3.79	No	Yes	0	6	5
398	R:R:S184	R:R:Y203	3.82	No	Yes	0	5	5
399	R:R:S184	R:R:S207	4.89	No	No	0	5	6
400	L:L:M12	R:R:S184	4.6	Yes	No	0	0	5
401	R:R:K187	R:R:Q200	4.07	No	No	15	3	2
402	R:R:K187	R:R:Y203	3.58	No	Yes	15	3	5
403	R:R:A198	R:R:D195	4.63	No	No	0	1	3
404	R:R:Q200	R:R:Y203	9.02	No	Yes	15	2	5
405	R:R:D201	R:R:N205	4.04	No	Yes	0	2	6
406	L:L:Q5	R:R:D201	6.53	No	No	0	0	2
407	L:L:L6	R:R:D201	4.07	Yes	No	0	0	2
408	L:L:W3	R:R:K202	10.44	No	No	0	0	3
409	R:R:F204	R:R:T208	7.78	Yes	Yes	1	5	6
410	L:L:L4	R:R:F204	3.65	Yes	Yes	1	0	5
411	L:L:L6	R:R:F204	15.83	Yes	Yes	1	0	5
412	L:L:M12	R:R:F204	7.46	Yes	Yes	0	0	5
413	L:L:Y13	R:R:F204	11.35	Yes	Yes	1	0	5
414	R:R:N205	R:R:Y266	3.49	Yes	Yes	1	6	6
415	L:L:W3	R:R:N205	13.56	No	Yes	0	0	6
416	L:L:L4	R:R:N205	5.49	Yes	Yes	1	0	6
417	R:R:T208	R:R:Y266	6.24	Yes	Yes	1	6	6
418	R:R:T208	R:R:T278	3.14	Yes	Yes	0	6	5
419	L:L:L4	R:R:T208	4.42	Yes	Yes	1	0	6
420	R:R:I209	R:R:Y266	6.04	No	Yes	0	8	6
421	R:R:I215	R:R:L211	4.28	No	No	0	8	6
422	R:R:A212	R:R:F262	9.71	No	No	0	7	7
423	R:R:M218	R:R:S214	3.07	Yes	No	0	8	9
424	R:R:A285	R:R:I215	4.87	No	No	0	9	8
425	R:R:F220	R:R:N216	7.25	No	No	16	4	7
426	R:R:L255	R:R:N216	4.12	Yes	No	16	9	7
427	R:R:N216	R:R:S259	7.45	No	No	0	7	8
428	R:R:F217	R:R:V221	5.24	Yes	No	0	6	7
429	R:R:S219	R:R:S254	4.89	No	No	0	9	9
430	R:R:L255	R:R:S219	4.5	Yes	No	0	9	9
431	R:R:F220	R:R:L255	10.96	No	Yes	16	4	9
432	R:R:L222	R:R:S251	6.01	No	No	0	9	8
433	R:R:I227	R:R:L248	5.71	No	No	0	5	8
434	R:R:H245	R:R:I230	11.93	No	No	0	9	9
435	R:R:L238	R:R:R233	8.5	No	No	0	8	9
436	R:R:D242	R:R:R233	7.15	No	No	0	8	9
437	R:R:F244	R:R:R233	6.41	No	No	0	9	9
438	R:R:G237	R:R:L238	3.42	No	No	0	9	8
439	R:R:F241	R:R:H245	7.92	No	No	0	9	9
440	R:R:F241	R:R:I246	3.77	No	Yes	0	9	8
441	R:R:D242	R:R:H245	8.82	No	No	0	8	9
442	R:R:A296	R:R:S243	3.42	No	No	0	9	7
443	R:R:I246	R:R:W295	18.79	Yes	Yes	0	8	9
444	R:R:I249	R:R:W295	4.7	No	Yes	0	9	9
445	R:R:M250	R:R:S292	3.07	No	No	0	9	9
446	R:R:M250	R:R:W295	3.49	No	Yes	0	9	9
447	R:R:Q253	R:R:V257	7.16	No	No	0	9	7
448	R:R:L284	R:R:Q253	3.99	No	No	0	6	9
449	R:R:S254	R:R:S288	6.52	No	No	0	9	8
450	R:R:P258	R:R:V257	3.53	No	No	0	9	7
451	R:R:I261	R:R:L277	4.28	No	No	0	7	7
452	R:R:A281	R:R:I261	3.25	No	No	0	7	7
453	R:R:F262	R:R:T278	6.49	No	Yes	0	7	5
454	R:R:A281	R:R:F262	5.55	No	No	0	7	7
455	L:L:L4	R:R:Y266	11.72	Yes	Yes	1	0	6
456	R:R:L268	R:R:T274	7.37	No	No	0	4	6
457	R:R:K269	R:R:P270	3.35	No	No	0	2	2
458	R:R:N271	R:R:P270	4.89	No	No	0	4	2
459	L:L:H2	R:R:P270	10.68	No	No	0	0	2
460	L:L:H2	R:R:D275	10.08	No	No	0	0	5
461	L:L:L4	R:R:D275	4.07	Yes	No	1	0	5
462	L:L:Y13	R:R:D275	5.75	Yes	No	1	0	5
463	L:L:Y13	R:R:V276	7.57	Yes	Yes	1	0	5
464	L:L:Y13	R:R:T278	4.99	Yes	Yes	0	0	5
465	R:R:L283	R:R:L287	8.3	No	No	0	8	8
466	R:R:L289	R:R:S292	4.5	Yes	No	0	9	9
467	R:R:K304	R:R:N300	6.99	No	No	0	4	7
468	R:R:N301	R:R:T305	10.24	Yes	No	0	6	4
469	R:R:N306	R:R:T305	4.39	No	No	0	5	4
470	M:M:L6	M:M:Y13	3.52	No	Yes	2	0	0
471	M:M:K7	M:M:P8	3.35	No	No	0	0	0
472	M:M:K7	M:M:Q10	6.78	No	Yes	2	0	0
473	M:M:P11	M:M:Q10	3.16	Yes	Yes	2	0	0
474	M:M:Q10	M:M:Y13	4.51	Yes	Yes	2	0	0
475	L:L:L4	L:L:Y13	5.86	Yes	Yes	1	0	0
476	L:L:L6	L:L:Y13	4.69	Yes	Yes	1	0	0
477	L:L:K7	L:L:Q10	13.56	No	Yes	0	0	0
478	L:L:P11	L:L:Q10	3.16	Yes	Yes	1	0	0
479	L:L:Q10	L:L:Y13	6.76	Yes	Yes	1	0	0
480	R:R:K304	R:R:S303	3.06	No	No	0	4	4
481	R:R:M294	S:S:V68	3.04	No	No	0	8	7
482	S:S:I83	S:S:T144	3.04	No	No	0	7	3
483	S:S:M218	S:S:V147	3.04	Yes	No	0	8	7
484	S:S:M180	S:S:V183	3.04	No	No	0	6	6
485	R:R:V68	S:S:M294	3.04	Yes	No	0	7	8
486	R:R:M54	R:R:V280	3.04	No	No	0	7	7
487	R:R:M71	R:R:V68	3.04	Yes	Yes	0	7	7
488	R:R:I83	R:R:T144	3.04	No	No	0	7	3
489	R:R:I142	R:R:T282	3.04	Yes	No	0	8	5
490	R:R:M218	R:R:V147	3.04	Yes	No	0	8	7
491	S:S:F99	S:S:G56	3.01	Yes	No	0	5	7
492	R:R:F99	R:R:G56	3.01	No	No	0	5	7
493	S:S:L222	S:S:S251	3	No	Yes	0	9	8
494	S:S:L226	S:S:S251	3	No	Yes	0	9	8
495	R:R:K151	R:R:T167	3	No	No	0	6	7
496	R:R:L164	R:R:S168	3	No	No	0	1	3
497	R:R:L226	R:R:S251	3	No	No	0	9	8
498	R:R:L247	R:R:S292	3	No	No	0	9	9
499	S:S:L90	S:S:V86	2.98	No	No	0	4	4
500	R:R:L41	S:S:V109	2.98	No	No	0	5	5
501	R:R:L41	R:R:V109	2.98	No	No	0	5	5
502	R:R:L90	R:R:V86	2.98	Yes	No	0	4	4
503	R:R:L248	R:R:V223	2.98	No	No	0	8	6
504	R:R:L255	R:R:V223	2.98	Yes	No	0	9	6
505	S:S:L210	S:S:T177	2.95	No	No	0	6	8
506	L:L:L6	R:R:T199	2.95	Yes	No	0	0	1
507	R:R:D124	R:R:S104	2.94	Yes	No	0	6	6
508	R:R:D195	R:R:S197	2.94	No	No	0	3	3
509	R:R:I67	R:R:M71	2.92	No	Yes	0	5	7
510	S:S:I82	S:S:K77	2.91	No	No	0	5	6
511	S:S:I190	S:S:K187	2.91	No	No	0	4	3
512	S:S:G129	S:S:Y128	2.9	No	Yes	0	6	8
513	S:S:G188	S:S:Y128	2.9	No	Yes	0	8	8
514	S:S:I134	S:S:L90	2.85	No	No	0	5	4
515	S:S:I134	S:S:L97	2.85	No	No	0	5	7
516	S:S:I142	S:S:L146	2.85	No	No	0	8	9
517	S:S:E143	S:S:V178	2.85	Yes	No	0	8	6
518	S:S:I153	S:S:L222	2.85	No	No	0	8	9
519	S:S:I162	S:S:L166	2.85	No	No	0	4	7
520	S:S:I230	S:S:L248	2.85	No	No	0	9	8
521	S:S:I260	S:S:L256	2.85	No	No	0	8	6
522	R:R:E143	R:R:V178	2.85	Yes	No	0	8	6
523	R:R:I162	R:R:L166	2.85	No	No	0	4	7
524	R:R:I260	R:R:L256	2.85	No	No	0	8	6
525	R:R:T16	S:S:Q118	2.83	No	No	0	5	7
526	R:R:Q272	R:R:T274	2.83	No	No	0	1	6
527	R:R:E40	R:R:T37	2.82	No	No	0	3	6
528	S:S:L137	S:S:L90	2.77	No	No	0	6	4
529	S:S:A229	S:S:F244	2.77	No	Yes	0	9	9
530	S:S:L264	S:S:L268	2.77	No	No	0	7	4
531	R:R:L113	R:R:L44	2.77	No	No	0	7	4
532	R:R:L137	R:R:L90	2.77	No	Yes	0	6	4
533	R:R:L138	R:R:L90	2.77	Yes	Yes	0	8	4
534	R:R:L226	R:R:L248	2.77	No	No	0	9	8
535	R:R:A229	R:R:F244	2.77	No	No	0	9	9
536	R:R:M250	R:R:Q253	2.72	No	No	0	9	9
537	S:S:D14	S:S:L11	2.71	No	No	0	6	3
538	M:M:L6	S:S:D201	2.71	No	No	0	0	2
539	R:R:K269	R:R:Q272	2.71	No	No	0	2	1
540	R:R:F12	R:R:S9	2.64	No	No	0	1	7
541	S:S:F182	S:S:V136	2.62	No	No	0	5	5
542	S:S:F171	S:S:V147	2.62	No	No	0	3	7
543	M:M:Q5	S:S:D201	2.61	No	No	0	0	2
544	S:S:R58	S:S:T282	2.59	Yes	No	0	9	5
545	S:S:S184	S:S:Y203	2.54	No	No	0	5	5
546	R:R:S9	R:R:Y13	2.54	No	No	0	7	2
547	R:R:S197	R:R:Y111	2.54	No	No	0	3	5
548	R:R:K239	R:R:R234	2.48	No	No	0	6	8
549	L:L:W1	R:R:S267	2.47	No	No	0	0	4
550	R:R:F89	R:R:L66	2.44	No	No	0	4	5
551	S:S:M180	S:S:Y203	2.39	No	No	0	6	5
552	M:M:W1	S:S:I263	2.35	No	No	0	0	7
553	S:S:C59	S:S:G60	1.96	No	No	0	7	9
554	R:R:C59	R:R:G60	1.96	No	No	0	7	9
555	M:M:W1	S:S:Y266	1.93	No	Yes	0	0	6
556	L:L:W1	R:R:Y266	1.93	No	Yes	0	0	6
557	S:S:G31	S:S:S34	1.86	No	Yes	0	8	6
558	S:S:G33	S:S:S34	1.86	No	Yes	0	2	6
559	R:R:G31	R:R:S28	1.86	No	No	0	8	4
560	R:R:G33	R:R:S34	1.86	No	No	0	2	6
561	R:R:G273	R:R:S47	1.86	No	No	0	3	5
562	R:R:V57	S:S:G56	1.84	No	No	0	6	7
563	R:R:V57	S:S:G60	1.84	No	No	0	6	9
564	R:R:T110	S:S:G20	1.82	Yes	No	0	7	3
565	R:R:G20	S:S:T110	1.82	No	Yes	0	3	7
566	S:S:G156	S:S:T155	1.82	No	No	0	7	6
567	R:R:G156	R:R:T155	1.82	No	No	0	7	6
568	L:L:P8	R:R:S197	1.78	No	No	0	0	3
569	S:S:P117	S:S:V196	1.77	No	No	0	4	1
570	S:S:P15	S:S:T16	1.75	No	No	0	5	5
571	R:R:P15	R:R:T16	1.75	No	No	0	5	5
572	R:R:P79	R:R:T78	1.75	No	No	0	4	8
573	R:R:G237	R:R:K239	1.74	No	No	0	9	6
574	S:S:C252	S:S:V223	1.71	No	No	0	7	6
575	S:S:A296	S:S:S243	1.71	No	No	0	9	7
576	R:R:C252	R:R:V223	1.71	No	No	0	7	6
577	S:S:G43	S:S:N46	1.7	No	No	0	1	5
578	S:S:A185	S:S:V136	1.7	No	No	0	6	5
579	S:S:A198	S:S:V191	1.7	No	No	0	1	3
580	R:R:A185	R:R:V136	1.7	No	No	0	6	5
581	R:R:A198	R:R:V191	1.7	No	No	0	1	3
582	S:S:D157	S:S:G156	1.68	No	No	0	6	7
583	S:S:D157	S:S:G163	1.68	No	No	0	6	7
584	S:S:A265	S:S:T278	1.68	No	Yes	0	8	5
585	R:R:D39	R:R:G20	1.68	No	No	0	1	3
586	R:R:A265	R:R:T278	1.68	No	Yes	0	8	5
587	R:R:G273	R:R:Q51	1.64	No	Yes	0	3	4
588	S:S:N18	S:S:P19	1.63	No	Yes	0	7	7
589	S:S:S251	S:S:S254	1.63	Yes	No	0	8	9
590	R:R:N18	R:R:P19	1.63	No	Yes	0	7	7
591	S:S:S141	S:S:V86	1.62	No	No	0	6	4
592	S:S:S87	S:S:V286	1.62	No	No	0	8	8
593	S:S:S251	S:S:V223	1.62	Yes	No	0	8	6
594	S:S:A299	S:S:I246	1.62	No	No	0	6	8
595	R:R:A296	R:R:I246	1.62	No	Yes	0	9	8
596	R:R:A299	R:R:I246	1.62	No	Yes	0	6	8
597	S:S:D14	S:S:P15	1.61	No	No	0	6	5
598	S:S:A206	S:S:M180	1.61	No	No	0	5	6
599	M:M:M12	S:S:A185	1.61	No	No	0	0	6
600	R:R:A206	R:R:M180	1.61	No	No	0	5	6
601	L:L:M12	R:R:A185	1.61	Yes	No	0	0	6
602	S:S:S75	S:S:T78	1.6	No	No	0	5	8
603	R:R:S293	R:R:T297	1.6	No	No	0	9	6
604	S:S:G123	S:S:H126	1.59	No	No	0	5	6
605	S:S:T192	S:S:V125	1.59	No	No	0	6	4
606	S:S:T131	S:S:V127	1.59	Yes	No	0	6	5
607	S:S:T155	S:S:V152	1.59	No	No	0	6	8
608	S:S:T179	S:S:V183	1.59	No	No	0	5	6
609	R:R:T192	R:R:V125	1.59	No	No	0	6	4
610	R:R:T131	R:R:V127	1.59	Yes	No	0	6	5
611	R:R:T155	R:R:V152	1.59	No	No	0	6	8
612	S:S:A112	S:S:L44	1.58	No	No	0	3	4
613	R:R:A112	R:R:L44	1.58	No	No	0	3	4
614	R:R:A176	R:R:L210	1.58	No	No	0	6	6
615	S:S:A302	S:S:N301	1.56	No	Yes	0	5	6
616	S:S:I83	S:S:S145	1.55	No	No	0	7	9
617	R:R:I80	R:R:S145	1.55	No	No	0	7	9
618	R:R:I263	R:R:S259	1.55	No	No	0	7	8
619	S:S:I227	S:S:V223	1.54	No	No	0	5	6
620	R:R:I82	R:R:V86	1.54	No	No	0	5	4
621	R:R:I190	R:R:V191	1.54	No	No	0	4	3
622	S:S:K100	S:S:V127	1.52	No	No	0	4	5
623	S:S:I175	S:S:T179	1.52	No	No	0	4	5
624	R:R:K100	R:R:V127	1.52	No	No	0	4	5
625	R:R:I175	R:R:T179	1.52	No	No	0	4	5
626	S:S:M54	S:S:T50	1.51	Yes	No	0	7	4
627	S:S:K151	S:S:T167	1.5	No	No	0	6	7
628	S:S:L41	S:S:V45	1.49	No	No	0	5	4
629	R:R:V109	S:S:L41	1.49	No	No	0	5	5
630	S:S:L228	S:S:V224	1.49	No	No	0	3	4
631	R:R:L228	R:R:V224	1.49	No	No	0	3	4
632	S:S:N25	S:S:T23	1.46	No	No	7	7	5
633	S:S:N25	S:S:T35	1.46	No	No	7	7	4
634	S:S:I133	S:S:M189	1.46	No	No	0	6	5
635	S:S:N306	S:S:T305	1.46	No	No	0	5	4
636	R:R:N301	S:S:T305	1.46	Yes	No	0	6	4
637	R:R:N25	R:R:T35	1.46	No	No	0	7	4
638	R:R:N32	R:R:T27	1.46	No	No	0	5	5
639	R:R:I162	R:R:M165	1.46	No	No	0	4	2
640	R:R:I169	R:R:M165	1.46	No	No	0	4	2
641	R:R:G188	R:R:Y128	1.45	No	Yes	0	8	8
642	S:S:I260	S:S:L264	1.43	No	No	0	8	7
643	R:R:I133	R:R:L137	1.43	No	No	0	6	6
644	R:R:I260	R:R:L264	1.43	No	No	0	8	7
645	S:S:L113	S:S:L44	1.38	No	No	0	7	4
646	R:R:D157	R:R:K160	1.38	No	No	0	6	5
647	R:R:L264	R:R:L268	1.38	No	No	0	7	4
648	S:S:L255	S:S:N216	1.37	No	No	0	9	7
649	R:R:N25	S:S:N25	1.36	No	No	0	7	7
650	S:S:D195	S:S:N194	1.35	No	No	0	3	1
651	S:S:F12	S:S:S9	1.32	No	No	0	1	7
652	S:S:N18	S:S:Q21	1.32	No	No	0	7	4
653	S:S:R74	S:S:S75	1.32	Yes	No	0	6	5
654	S:S:D39	S:S:E40	1.3	No	No	0	1	3
655	S:S:S104	S:S:Y101	1.27	No	Yes	0	6	6
656	S:S:S104	S:S:Y106	1.27	No	Yes	0	6	5
657	S:S:F81	S:S:I82	1.26	Yes	No	0	9	5
658	S:S:I227	S:S:R231	1.25	No	No	0	5	5
659	R:R:I227	R:R:R231	1.25	No	No	0	5	5
660	R:R:K77	R:R:R76	1.24	No	No	0	6	6
661	S:S:F89	S:S:L66	1.22	No	No	0	4	5
662	S:S:L228	S:S:R231	1.21	No	No	0	3	5
663	R:R:L228	R:R:R231	1.21	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:Y17	6.305	4	6	7
2	S:S:P19	5.2	4	6	7
3	S:S:Y26	6.675	4	8	6
4	S:S:S34	3.425	4	8	6
5	S:S:F38	7.4175	4	0	7
6	S:S:Q42	6.9225	4	0	7
7	S:S:Q51	5.32	4	2	4
8	S:S:M54	5.16	4	0	7
9	S:S:F55	10.7175	4	2	6
10	S:S:R58	5.02375	8	2	9
11	S:S:T65	4.56	4	0	7
12	S:S:R74	5.656	5	9	6
13	S:S:F81	6.36	5	3	9
14	S:S:I91	4.645	4	2	7
15	S:S:Y98	10.61	6	2	6
16	S:S:F99	7.35	4	0	5
17	S:S:Y101	7.005	6	2	6
18	S:S:Y106	7.258	5	10	5
19	S:S:T110	7.532	5	5	7
20	S:S:F116	7.844	5	5	7
21	S:S:Y128	7.048	5	0	8
22	S:S:T131	5.725	4	0	6
23	S:S:L138	4.7375	4	2	8
24	S:S:E143	5.528	5	0	8
25	S:S:I150	5.7075	4	11	8
26	S:S:F154	6.4275	4	0	9
27	S:S:Y181	10.1625	4	0	7
28	S:S:M218	4.92	4	11	8
29	S:S:F244	4.532	5	13	9
30	S:S:S251	2.3125	4	0	8
31	S:S:F262	6.41	4	2	7
32	S:S:Y266	7.84	4	12	6
33	S:S:V276	6.9875	4	2	5
34	S:S:T278	3.765	4	2	5
35	S:S:T279	5.5925	4	2	7
36	S:S:N301	8.1975	4	9	6
37	R:R:L11	5.4125	4	5	3
38	R:R:P19	4.895	4	5	7
39	R:R:Y26	6.398	5	0	6
40	R:R:I29	6.6025	4	0	4
41	R:R:F38	7.3925	4	0	7
42	R:R:Q42	8.725	4	0	7
43	R:R:Q51	4.998	5	1	4
44	R:R:F55	8.41667	6	1	6
45	R:R:R58	7.13714	7	1	9
46	R:R:V68	3.4525	4	0	7
47	R:R:M69	4.7425	4	4	8
48	R:R:W70	7.5125	4	4	4
49	R:R:M71	8.2025	4	0	7
50	R:R:F81	6.37333	6	4	9
51	R:R:L90	3.2	4	0	4
52	R:R:I91	5.54	4	1	7
53	R:R:H94	5.212	5	1	8
54	R:R:Y98	8.785	6	1	6
55	R:R:Y101	8.61	4	1	6
56	R:R:T110	4.298	5	0	7
57	R:R:F116	8.61	5	6	7
58	R:R:D124	5.8575	4	0	6
59	R:R:Y128	7.2075	4	0	8
60	R:R:T131	5.085	4	0	6
61	R:R:L138	3.7425	4	1	8
62	R:R:I142	3.3725	4	1	8
63	R:R:E143	6.27	4	0	8
64	R:R:I150	6.8175	4	14	8
65	R:R:F154	6.332	5	0	9
66	R:R:Y181	11.3625	4	0	7
67	R:R:Y203	5	5	15	5
68	R:R:F204	9.214	5	1	5
69	R:R:N205	6.645	4	1	6
70	R:R:T208	5.395	4	1	6
71	R:R:F217	4.705	4	0	6
72	R:R:M218	5.344	5	14	8
73	R:R:I246	6.45	4	0	8
74	R:R:L255	5.64	4	16	9
75	R:R:Y266	5.884	5	1	6
76	R:R:V276	6.165	4	1	5
77	R:R:T278	4.075	4	0	5
78	R:R:L289	7.915	4	0	9
79	R:R:W295	10.235	4	0	9
80	R:R:N301	7.42	4	9	6
81	M:M:Q10	5.67833	6	2	0
82	M:M:P11	6.48	5	2	0
83	M:M:Y13	6.42429	7	2	0
84	L:L:L4	5.86833	6	1	0
85	L:L:L6	6.885	4	1	0
86	L:L:Q10	6.83333	6	1	0
87	L:L:P11	6.552	5	1	0
88	L:L:M12	5.776	5	0	0
89	L:L:Y13	6.04667	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T110	S:S:P19	10.7375	3.5	Yes	Yes	0	7	7
2	R:R:T110	S:S:F38	19.5184	5.19	Yes	Yes	0	7	7
3	R:R:Y26	S:S:F38	19.5647	4.13	Yes	Yes	0	6	7
4	R:R:I24	R:R:Y26	19.6035	4.84	No	Yes	0	6	6
5	R:R:F38	R:R:I24	19.6018	10.05	Yes	No	0	7	6
6	R:R:F38	S:S:T114	10.938	3.89	Yes	No	0	7	7
7	S:S:S28	S:S:T114	12.5973	3.2	No	No	0	4	7
8	R:R:S108	R:R:T110	18.1193	3.2	No	Yes	0	7	7
9	R:R:S108	S:S:Q42	18.2979	5.78	No	Yes	0	7	7
10	S:S:Q42	S:S:V45	82.3692	5.73	Yes	No	0	7	4
11	S:S:N46	S:S:Q42	100	11.88	No	Yes	0	5	7
12	R:R:V45	S:S:V45	82.3574	8.02	No	No	0	4	4
13	R:R:L103	S:S:N46	99.7827	4.12	No	No	0	7	5
14	R:R:F38	S:S:T110	22.041	11.67	Yes	Yes	0	7	7
15	S:S:F119	S:S:T110	91.7093	14.27	No	Yes	5	3	7
16	S:S:F119	S:S:N105	98.9101	16.92	No	No	0	3	3
17	S:S:D124	S:S:N105	98.8082	5.39	No	No	0	6	3
18	S:S:D124	S:S:Y106	98.7046	3.45	No	Yes	0	6	5
19	S:S:S104	S:S:Y106	97.5144	1.27	No	Yes	0	6	5
20	S:S:S104	S:S:Y101	97.4007	1.27	No	Yes	0	6	6
21	S:S:Y101	S:S:Y98	55.6568	10.92	Yes	Yes	2	6	6
22	M:M:Q10	S:S:Y101	23.7964	9.02	Yes	Yes	2	0	6
23	R:R:Q42	R:R:V45	82.3591	5.73	Yes	No	0	7	4
24	S:S:I53	S:S:V49	99.5586	3.07	No	No	0	7	6
25	R:R:L103	S:S:V49	99.6715	4.47	No	No	0	7	6
26	M:M:Q10	M:M:Y13	20.7742	4.51	Yes	Yes	2	0	0
27	S:S:F55	S:S:Y98	55.0268	28.88	Yes	Yes	2	6	6
28	R:R:F99	S:S:I53	99.3279	18.84	No	No	0	5	7
29	S:S:M54	S:S:V276	14.5969	6.09	Yes	Yes	0	7	5
30	S:S:L277	S:S:M54	10.6322	8.48	No	Yes	0	7	7
31	S:S:F55	S:S:R58	52.2978	4.28	Yes	Yes	2	6	9
32	R:R:C59	R:R:F99	99.0903	4.19	No	No	0	7	5
33	M:M:P11	S:S:T131	12.0464	6.99	Yes	Yes	0	0	6
34	M:M:P11	S:S:Y101	17.6864	12.52	Yes	Yes	2	0	6
35	S:S:L138	S:S:R58	16.9064	3.64	Yes	Yes	2	8	9
36	S:S:L283	S:S:R58	44.798	7.29	No	Yes	0	8	9
37	R:R:L283	R:R:R58	59.4707	6.07	No	Yes	0	8	9
38	R:R:R58	R:R:S95	98.5951	3.95	Yes	No	0	9	8
39	R:R:C59	R:R:S95	98.7214	5.16	No	No	0	7	8
40	S:S:L283	S:S:L287	43.3324	6.92	No	No	0	8	8
41	S:S:L287	S:S:T65	42.8995	4.42	No	Yes	0	8	7
42	S:S:P290	S:S:T65	42.2012	3.5	No	Yes	0	9	7
43	S:S:N84	S:S:P290	36.1831	11.4	No	No	3	9	9
44	S:S:L289	S:S:N84	36.6152	10.98	No	No	0	9	9
45	S:S:L289	S:S:Q149	35.7384	11.98	No	No	0	9	9
46	S:S:L222	S:S:Q149	33.5754	5.32	No	No	0	9	9
47	S:S:L222	S:S:S251	33.3134	3	No	Yes	0	9	8
48	S:S:L226	S:S:S251	26.2146	3	No	Yes	0	9	8
49	S:S:F244	S:S:L226	25.1735	4.87	Yes	No	0	9	9
50	S:S:D242	S:S:F244	21.3958	3.58	No	Yes	13	8	9
51	S:S:D242	S:S:H245	20.9553	13.87	No	No	0	8	9
52	S:S:F241	S:S:H245	19.3407	6.79	No	No	0	9	9
53	S:S:F241	S:S:I246	18.7991	3.77	No	No	0	9	8
54	S:S:I246	S:S:W295	17.7243	15.27	No	No	0	8	9
55	R:R:M71	S:S:W295	16.6335	19.78	Yes	No	0	7	9
56	R:R:M71	R:R:V68	14.9784	3.04	Yes	Yes	0	7	7
57	R:R:M250	R:R:W295	10.8975	3.49	No	Yes	0	9	9
58	R:R:M250	R:R:S292	13.6704	3.07	No	No	0	9	9
59	R:R:L289	R:R:S292	14.767	4.5	Yes	No	0	9	9
60	R:R:L289	R:R:N84	50.1718	8.24	Yes	No	0	9	9
61	R:R:N84	R:R:P290	49.4155	11.4	No	No	4	9	9
62	R:R:P290	R:R:T65	56.735	3.5	No	No	0	9	7
63	R:R:L287	R:R:T65	57.525	4.42	No	No	0	8	7
64	R:R:L283	R:R:L287	57.9175	8.3	No	No	0	8	8
65	S:S:S108	S:S:T110	83.2873	6.4	No	Yes	0	7	7
66	R:R:Q42	S:S:S108	83.2528	12.99	Yes	No	0	7	7
67	M:M:P11	S:S:Y128	21.7496	4.17	Yes	Yes	0	0	8
68	S:S:N132	S:S:Y128	15.6017	12.79	No	Yes	0	7	8
69	M:M:M12	S:S:N132	14.9102	12.62	No	No	0	0	7
70	S:S:I142	S:S:L138	16.8727	4.28	No	Yes	0	8	8
71	S:S:E143	S:S:L146	16.1829	3.98	Yes	No	0	8	9
72	S:S:I142	S:S:L146	16.6504	2.85	No	No	0	8	9
73	S:S:E143	S:S:S214	13.3781	8.62	Yes	No	0	8	9
74	S:S:I150	S:S:M218	11.0028	4.37	Yes	Yes	11	8	8
75	S:S:M218	S:S:S214	12.9072	3.07	Yes	No	0	8	9
76	M:M:M12	S:S:S184	11.4273	7.67	No	No	0	0	5
77	S:S:S184	S:S:Y203	10.7257	2.54	No	No	0	5	5
78	M:M:Y13	S:S:D275	10.5935	3.45	Yes	No	0	0	5
79	S:S:I261	S:S:V257	10.4756	3.07	No	No	0	7	7
80	R:R:F55	R:R:R58	29.6141	6.41	Yes	Yes	1	6	9
81	L:L:Y13	R:R:F55	16.8913	3.09	Yes	Yes	1	0	6
82	L:L:Y13	R:R:H94	17.2181	4.36	Yes	Yes	1	0	8
83	R:R:H94	R:R:R58	33.5122	5.64	Yes	Yes	1	8	9
84	R:R:H94	R:R:Q135	11.0837	7.42	Yes	No	0	8	6
85	R:R:I150	R:R:M218	15.659	7.29	Yes	Yes	14	8	8
86	R:R:F154	R:R:T167	10.0039	5.19	Yes	No	0	9	7
87	R:R:F154	R:R:K225	25.3773	6.2	Yes	No	0	9	9
88	R:R:I153	R:R:K225	25.8895	4.36	No	No	0	8	9
89	R:R:I153	R:R:L222	26.3999	7.14	No	No	0	8	9
90	R:R:L222	R:R:Q149	35.2995	6.65	No	No	0	9	9
91	R:R:L289	R:R:Q149	35.7628	14.64	Yes	No	0	9	9
92	R:R:F154	R:R:V221	11.1022	3.93	Yes	No	0	9	7
93	L:L:H2	R:R:D275	10.4267	10.08	No	No	0	0	5
94	L:L:Y13	R:R:D275	11.2008	5.75	Yes	No	1	0	5
95	R:R:P19	S:S:F116	10.7106	8.67	Yes	Yes	5	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:Q51	S:S:S47	4.33	2	Yes	No	4	5	1	2
S:S:Q51	S:S:Y98	4.51	2	Yes	Yes	4	6	1	1
S:S:Q51	S:S:V276	8.6	2	Yes	Yes	4	5	1	1
M:M:Q10	S:S:Q51	3.84	2	Yes	Yes	0	4	0	1
S:S:M54	S:S:V276	6.09	0	Yes	Yes	7	5	2	1
S:S:F55	S:S:R58	4.28	2	Yes	Yes	6	9	2	2
S:S:F55	S:S:Y98	28.88	2	Yes	Yes	6	6	2	1
S:S:F55	S:S:T279	6.49	2	Yes	Yes	6	7	2	1
S:S:H94	S:S:R58	5.64	0	No	Yes	8	9	2	2
S:S:R58	S:S:T279	6.47	2	Yes	Yes	9	7	2	1
S:S:H94	S:S:T131	5.48	0	No	Yes	8	6	2	1
S:S:L97	S:S:T131	8.84	0	No	Yes	7	6	2	1
S:S:Y101	S:S:Y98	10.92	2	Yes	Yes	6	6	1	1
S:S:L102	S:S:Y98	7.03	2	No	Yes	7	6	2	1
M:M:Q10	S:S:Y98	6.76	2	Yes	Yes	0	6	0	1
M:M:P11	S:S:Y98	5.56	2	Yes	Yes	0	6	0	1
S:S:L102	S:S:Y101	3.52	2	No	Yes	7	6	2	1
M:M:K7	S:S:Y101	4.78	2	No	Yes	0	6	0	1
M:M:Q10	S:S:Y101	9.02	2	Yes	Yes	0	6	0	1
M:M:P11	S:S:Y101	12.52	2	Yes	Yes	0	6	0	1
S:S:Y106	S:S:Y111	5.96	10	Yes	No	5	5	1	1
S:S:I120	S:S:Y106	16.92	10	No	Yes	7	5	2	1
S:S:D124	S:S:Y106	3.45	0	No	Yes	6	5	2	1
M:M:G9	S:S:Y106	8.69	0	No	Yes	0	5	0	1
S:S:I120	S:S:Y111	12.09	10	No	No	7	5	2	1
M:M:P8	S:S:Y111	4.17	0	No	No	0	5	0	1
S:S:N132	S:S:Y128	12.79	0	No	Yes	7	8	1	1
S:S:T192	S:S:Y128	12.48	0	No	Yes	6	8	2	1
M:M:P11	S:S:Y128	4.17	2	Yes	Yes	0	8	0	1
M:M:P11	S:S:T131	6.99	2	Yes	Yes	0	6	0	1
M:M:M12	S:S:N132	12.62	0	No	No	0	7	0	1
M:M:M12	S:S:S184	7.67	0	No	No	0	5	0	1
S:S:D201	S:S:T199	8.67	0	No	No	2	1	1	2
S:S:F204	S:S:T208	7.78	2	No	No	5	6	1	2
M:M:L6	S:S:F204	10.96	2	No	No	0	5	0	1
M:M:Y13	S:S:F204	13.41	2	Yes	No	0	5	0	1
S:S:N205	S:S:Y266	5.81	12	No	Yes	6	6	1	1
M:M:W3	S:S:N205	7.91	0	No	No	0	6	0	1
M:M:L4	S:S:N205	5.49	12	No	No	0	6	0	1
S:S:F262	S:S:T208	3.89	2	Yes	No	7	6	2	2
S:S:T208	S:S:T278	3.14	2	No	Yes	6	5	2	1
S:S:I209	S:S:Y266	6.04	0	No	Yes	8	6	2	1
S:S:F262	S:S:T278	6.49	2	Yes	Yes	7	5	2	1
M:M:L4	S:S:Y266	17.58	12	No	Yes	0	6	0	1
M:M:W1	S:S:S267	6.18	0	No	No	0	4	0	1
S:S:K269	S:S:P270	3.35	0	No	No	2	2	2	1
S:S:N271	S:S:P270	6.52	0	No	No	4	2	2	1
M:M:H2	S:S:P270	15.25	0	No	No	0	2	0	1
M:M:H2	S:S:D275	8.82	0	No	No	0	5	0	1
M:M:L4	S:S:D275	5.43	12	No	No	0	5	0	1
M:M:Y13	S:S:D275	3.45	2	Yes	No	0	5	0	1
S:S:T279	S:S:V276	3.17	2	Yes	Yes	7	5	1	1
M:M:Y13	S:S:V276	10.09	2	Yes	Yes	0	5	0	1
M:M:Y13	S:S:T278	3.75	2	Yes	Yes	0	5	0	1
M:M:Y13	S:S:T279	6.24	2	Yes	Yes	0	7	0	1
S:S:G129	S:S:Y128	2.9	0	No	Yes	6	8	2	1
S:S:G188	S:S:Y128	2.9	0	No	Yes	8	8	2	1
M:M:L6	S:S:D201	2.71	2	No	No	0	2	0	1
M:M:Q5	S:S:D201	2.61	0	No	No	0	2	0	1
S:S:S184	S:S:Y203	2.54	0	No	No	5	5	1	2
M:M:W1	S:S:I263	2.35	0	No	No	0	7	0	1
M:M:W1	S:S:Y266	1.93	0	No	Yes	0	6	0	1
S:S:A185	S:S:V136	1.7	0	No	No	6	5	1	2
S:S:A265	S:S:T278	1.68	0	No	Yes	8	5	2	1
M:M:M12	S:S:A185	1.61	0	No	No	0	6	0	1
S:S:T131	S:S:V127	1.59	0	Yes	No	6	5	1	2
S:S:S104	S:S:Y101	1.27	0	No	Yes	6	6	2	1
S:S:S104	S:S:Y106	1.27	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q51	R:R:Y98	5.64	1	Yes	Yes	4	6	1	1
R:R:L102	R:R:Q51	3.99	1	No	Yes	7	4	2	1
R:R:Q51	R:R:V276	8.6	1	Yes	Yes	4	5	1	1
L:L:Q10	R:R:Q51	5.12	1	Yes	Yes	0	4	0	1
R:R:M54	R:R:V276	4.56	0	No	Yes	7	5	2	1
R:R:F55	R:R:R58	6.41	1	Yes	Yes	6	9	1	2
R:R:F55	R:R:H94	4.53	1	Yes	Yes	6	8	1	1
R:R:F55	R:R:Y98	24.76	1	Yes	Yes	6	6	1	1
R:R:F55	R:R:V276	3.93	1	Yes	Yes	6	5	1	1
R:R:F55	R:R:T279	7.78	1	Yes	No	6	7	1	2
L:L:Y13	R:R:F55	3.09	1	Yes	Yes	0	6	0	1
R:R:H94	R:R:R58	5.64	1	Yes	Yes	8	9	1	2
R:R:R58	R:R:T279	14.23	1	Yes	No	9	7	2	2
R:R:H94	R:R:T131	4.11	1	Yes	Yes	8	6	1	1
R:R:H94	R:R:Q135	7.42	1	Yes	No	8	6	1	1
L:L:Y13	R:R:H94	4.36	1	Yes	Yes	0	8	0	1
R:R:L97	R:R:T131	5.9	0	No	Yes	7	6	2	1
R:R:Y101	R:R:Y98	8.94	1	Yes	Yes	6	6	1	1
R:R:L102	R:R:Y98	4.69	1	No	Yes	7	6	2	1
L:L:Q10	R:R:Y98	4.51	1	Yes	Yes	0	6	0	1
L:L:P11	R:R:Y98	4.17	1	Yes	Yes	0	6	0	1
R:R:S107	R:R:Y101	5.09	0	No	Yes	5	6	2	1
L:L:Q10	R:R:Y101	7.89	1	Yes	Yes	0	6	0	1
L:L:P11	R:R:Y101	12.52	1	Yes	Yes	0	6	0	1
R:R:I120	R:R:Y106	14.51	0	No	No	7	5	2	1
R:R:D124	R:R:Y106	3.45	0	Yes	No	6	5	2	1
L:L:G9	R:R:Y106	5.79	0	No	No	0	5	0	1
R:R:I120	R:R:Y111	12.09	0	No	No	7	5	2	2
R:R:N132	R:R:Y128	6.98	0	No	Yes	7	8	1	1
R:R:T192	R:R:Y128	16.23	0	No	Yes	6	8	2	1
L:L:P11	R:R:Y128	4.17	1	Yes	Yes	0	8	0	1
L:L:P11	R:R:T131	8.74	1	Yes	Yes	0	6	0	1
R:R:M189	R:R:N132	4.21	0	No	No	5	7	2	1
L:L:M12	R:R:N132	8.41	0	Yes	No	0	7	0	1
R:R:Q135	R:R:Y181	6.76	0	No	Yes	6	7	1	2
L:L:M12	R:R:Q135	6.8	0	Yes	No	0	6	0	1
R:R:S207	R:R:Y181	15.26	0	No	Yes	6	7	2	2
R:R:S184	R:R:Y203	3.82	0	No	Yes	5	5	1	2
R:R:S184	R:R:S207	4.89	0	No	No	5	6	1	2
L:L:M12	R:R:S184	4.6	0	Yes	No	0	5	0	1
R:R:D201	R:R:N205	4.04	0	No	Yes	2	6	1	1
L:L:Q5	R:R:D201	6.53	0	No	No	0	2	0	1
L:L:L6	R:R:D201	4.07	1	Yes	No	0	2	0	1
L:L:W3	R:R:K202	10.44	0	No	No	0	3	0	1
R:R:F204	R:R:T208	7.78	1	Yes	Yes	5	6	1	1
L:L:L4	R:R:F204	3.65	1	Yes	Yes	0	5	0	1
L:L:L6	R:R:F204	15.83	1	Yes	Yes	0	5	0	1
L:L:M12	R:R:F204	7.46	0	Yes	Yes	0	5	0	1
L:L:Y13	R:R:F204	11.35	1	Yes	Yes	0	5	0	1
R:R:N205	R:R:Y266	3.49	1	Yes	Yes	6	6	1	1
L:L:W3	R:R:N205	13.56	0	No	Yes	0	6	0	1
L:L:L4	R:R:N205	5.49	1	Yes	Yes	0	6	0	1
R:R:T208	R:R:Y266	6.24	1	Yes	Yes	6	6	1	1
R:R:T208	R:R:T278	3.14	1	Yes	Yes	6	5	1	1
L:L:L4	R:R:T208	4.42	1	Yes	Yes	0	6	0	1
R:R:I209	R:R:Y266	6.04	0	No	Yes	8	6	2	1
R:R:F262	R:R:T278	6.49	0	No	Yes	7	5	2	1
L:L:L4	R:R:Y266	11.72	1	Yes	Yes	0	6	0	1
R:R:K269	R:R:P270	3.35	0	No	No	2	2	2	1
R:R:N271	R:R:P270	4.89	0	No	No	4	2	2	1
L:L:H2	R:R:P270	10.68	0	No	No	0	2	0	1
L:L:H2	R:R:D275	10.08	0	No	No	0	5	0	1
L:L:L4	R:R:D275	4.07	1	Yes	No	0	5	0	1
L:L:Y13	R:R:D275	5.75	1	Yes	No	0	5	0	1
L:L:Y13	R:R:V276	7.57	1	Yes	Yes	0	5	0	1
L:L:Y13	R:R:T278	4.99	1	Yes	Yes	0	5	0	1
L:L:L6	R:R:T199	2.95	1	Yes	No	0	1	0	1
R:R:D195	R:R:S197	2.94	0	No	No	3	3	2	1
R:R:S197	R:R:Y111	2.54	0	No	No	3	5	1	2
L:L:W1	R:R:S267	2.47	0	No	No	0	4	0	1
L:L:W1	R:R:Y266	1.93	0	No	Yes	0	6	0	1
L:L:P8	R:R:S197	1.78	0	No	No	0	3	0	1
R:R:A185	R:R:V136	1.7	0	No	No	6	5	1	2
R:R:A265	R:R:T278	1.68	0	No	Yes	8	5	2	1
R:R:G273	R:R:Q51	1.64	0	No	Yes	3	4	2	1
L:L:M12	R:R:A185	1.61	0	Yes	No	0	6	0	1
R:R:T131	R:R:V127	1.59	0	Yes	No	6	5	1	2
R:R:G188	R:R:Y128	1.45	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7AD3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	589
Number of Links	663
Number of Hubs	89
Number of Links mediated by Hubs	321
Number of Communities	16
Number of Nodes involved in Communities	101
Number of Links involved in Communities	142

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	238372
Length Of Smallest Path	3
Average Path Length	24.5473
Length of Longest Path	67
Minimum Path Strength	1.23
Average Path Strength	6.77803
Maximum Path Strength	19.9
Minimum Path Correlation	0.7
Average Path Correlation	0.951944
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.92308
Average % Of Corr. Nodes	41.0746
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.1868
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of cellular process • response to stimulus • sexual reproduction • signaling • regulation of reproductive process • reproductive process • positive regulation of biological process • regulation of conjugation with cellular fusion • regulation of signal transduction • response to pheromone • cell communication • cellular response to pheromone • positive regulation of conjugation with cellular fusion • signal transduction • positive regulation of reproductive process • pheromone-dependent signal transduction involved in conjugation with cellular fusion • regulation of biological process • regulation of signaling • regulation of signal transduction involved in conjugation with cellular fusion • signal transduction involved in positive regulation of conjugation with cellular fusion • biological regulation • conjugation with cellular fusion • response to pheromone triggering conjugation with cellular fusion • cellular response to chemical stimulus • regulation of response to stimulus • regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion • response to chemical • regulation of cell communication • cellular process • invasive growth in response to glucose limitation • growth • invasive filamentous growth • growth of unicellular organism as a thread of attached cells • filamentous growth • filamentous growth of a population of unicellular organisms • protein localization • localization • cellular localization • protein localization to cell tip • protein localization to mating projection tip • cellular macromolecule localization • macromolecule localization • chemotropism • tropism • response to external stimulus • establishment of protein localization • protein localization to cell periphery • establishment of protein localization to membrane • protein localization to plasma membrane • establishment of protein localization to plasma membrane • localization within membrane • protein localization to membrane • establishment of localization • G protein-coupled receptor signaling pathway • cell projection • mating projection • cellular anatomical structure • plasma membrane bounded cell projection • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane
Gene Ontology	Cellular Component	• cell projection • mating projection • cellular anatomical structure • plasma membrane bounded cell projection • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • G-protein beta/gamma-subunit complex • Cdc24p-Far1p-Gbetagamma complex • protein binding • binding • G-protein beta-subunit binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • carbohydrate metabolic process • regulation of biological process • regulation of cellular process • biological regulation • primary metabolic process • metabolic process • cellular process • regulation of carbohydrate metabolic process • regulation of metabolic process • regulation of primary metabolic process • cellular response to stimulus • sexual reproduction • response to stimulus • signaling • regulation of reproductive process • reproductive process • positive regulation of biological process • regulation of conjugation with cellular fusion • response to pheromone • cellular response to pheromone • cell communication • positive regulation of conjugation with cellular fusion • signal transduction • positive regulation of reproductive process • pheromone-dependent signal transduction involved in conjugation with cellular fusion • signal transduction involved in positive regulation of conjugation with cellular fusion • conjugation with cellular fusion • response to pheromone triggering conjugation with cellular fusion • cellular response to chemical stimulus • response to chemical • G protein-coupled receptor signaling pathway • establishment of organelle localization • cellular localization • organelle transport along microtubule • transport • nuclear migration involved in conjugation with cellular fusion • nucleus localization • intracellular transport • establishment of localization • localization • organelle localization • establishment of localization in cell • nuclear migration along microtubule • microtubule-based transport • transport along microtubule • cytoskeleton-dependent intracellular transport • microtubule-based movement • microtubule-based process • nuclear migration • organelle fusion • cellular component organization • organelle organization • nucleus organization • karyogamy • karyogamy involved in conjugation with cellular fusion • cellular component organization or biogenesis • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle • cytosol • endosome membrane • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • organelle membrane • regulation of signal transduction • regulation of signaling • regulation of signal transduction involved in conjugation with cellular fusion • regulation of response to stimulus • regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion • regulation of cell communication • peptide pheromone receptor activity • peptide receptor activity • molecular transducer activity • mating-type factor pheromone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • mating-type alpha-factor pheromone receptor activity • pheromone receptor activity • reproductive process in single-celled organism • cytogamy • G protein-coupled receptor homodimeric complex • receptor complex • G protein-coupled receptor dimeric complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • cupric ion binding • transition metal ion binding • copper ion binding • pheromone activity • molecular function activator activity • signaling receptor activator activity • mating pheromone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • mating • multi-organism reproductive process • extracellular region
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	S
Protein	Receptor
UniProt	P0CI39
Sequence	>7AD3_nogp_Chain_S M S D A A P S L S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I T F D E L Q G L V N S T V T Q A I M F G V R C G A A A L T L I V M W M T S R S R K T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S N Y S S V T Y A L T G F P Q F I S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T G D N F K R I G L M L T S I S F T L G I A T V T M Y F V S A V K G M I V T Y N D V S A T Q D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L G L K Q F D S F H I L L I M S C Q S L L V P S I I F I L A Y S L K P N Q G T D V L T T V A T L L A V L S L P L S S M W A T A A N N A S K T N T I T S D F T T S T D R F Y P G T L S S F Q T D S I N N D A K S S L R S R L Y D L Y P R R K E T T S D K H S E R T F V S E T A D D I E K N Q F Y Q L P T P T S S K N T R I G P F A D A S Y K E G E V E P V D M Y T P D T A A D E E A R K F W T E D N N N L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P0CI39
Sequence	>7AD3_nogp_Chain_R S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I T F D E L Q G L V N S T V T Q A I M F G V R C G A A A L T L I V M W M T S R S R K T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S N Y S S V T Y A L T G F P Q F I S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T G D N F K R I G L M L T S I S F T L G I A T V T M Y F V S A V K G M I V T Y N D V S A T Q D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L G L K Q F D S F H I L L I M S C Q S L L V P S I I F I L A Y S L K P N Q G T D V L T T V A T L L A V L S L P L S S M W A T A A N N A S K T N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	10.1038/s41586-022-04498-3
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	10.1038/s41586-022-04498-3
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	10.1038/s41586-020-2994-1

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