Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F12 6.38451
2R:R:Y17 6.6965117
3R:R:P19 5.834117
4R:R:Y26 4.9654156
5R:R:I29 5.685404
6R:R:Y30 5.045467
7R:R:F38 5.50167607
8R:R:F55 9.9675416
9R:R:R58 4.95571719
10R:R:L64 2.9354135
11R:R:W70 5.3575474
12R:R:F81 6.188579
13R:R:N84 3.744169
14R:R:Q85 10.3475475
15R:R:L88 2.9625409
16R:R:I91 4.3325407
17R:R:H94 4.474518
18R:R:Y98 10.7875416
19R:R:F99 4.656515
20R:R:Y101 4.6725406
21R:R:V109 2.6075405
22R:R:F116 7.176127
23R:R:F119 7.7125403
24R:R:V125 3.3654184
25R:R:Y128 5.325488
26R:R:V136 1.7825405
27R:R:F148 3.54177
28R:R:Q149 5.2025409
29R:R:I150 3.78408
30R:R:F154 5.15409
31R:R:F159 7.24401
32R:R:T177 4.68754198
33R:R:Y181 6.27507
34R:R:D195 2.56403
35R:R:V196 1.8375401
36R:R:Y203 7.92405
37R:R:I215 3.2054208
38R:R:F217 4.8025406
39R:R:M218 5.05508
40R:R:L222 4.0525409
41R:R:F241 7.14439
42R:R:L247 4.4925439
43R:R:P258 3.196676229
44R:R:F262 3.978336207
45R:R:Y266 4.0075406
46R:R:T278 1.54405
47R:R:L287 3.234148
48R:R:S293 2.9854169
49R:R:W295 5.17609
50R:R:N300 4.324217
51R:R:N301 4.13754216
52S:S:F12 6.38461
53S:S:Y17 7.3145127
54S:S:P19 5.834127
55S:S:Y26 4.9654236
56S:S:I29 5.685404
57S:S:Y30 5.3925457
58S:S:F38 5.50167607
59S:S:F55 9.9675426
60S:S:R58 4.95571729
61S:S:L64 2.9354145
62S:S:W70 5.3575494
63S:S:F81 6.188599
64S:S:N84 3.744249
65S:S:Q85 10.3475495
66S:S:L88 2.9625409
67S:S:I91 4.3325407
68S:S:H94 4.474528
69S:S:Y98 10.7875426
70S:S:F99 4.406525
71S:S:Y101 4.6725406
72S:S:V109 2.6075405
73S:S:F116 6.453336117
74S:S:F119 7.7125403
75S:S:V125 3.3654264
76S:S:Y128 5.3254108
77S:S:V136 1.7825405
78S:S:F148 3.54257
79S:S:Q149 5.2025409
80S:S:I150 3.78408
81S:S:F154 5.15409
82S:S:F159 7.24401
83S:S:T177 4.68754278
84S:S:Y181 6.27507
85S:S:D195 2.56403
86S:S:V196 1.8375401
87S:S:Y203 7.92405
88S:S:I215 3.2054288
89S:S:F217 4.8025406
90S:S:M218 5.05508
91S:S:L222 4.0525409
92S:S:F241 7.41449
93S:S:L247 4.4925449
94S:S:P258 3.196676309
95S:S:F262 3.978336287
96S:S:Y266 4.0075406
97S:S:T278 1.54405
98S:S:L287 3.234138
99S:S:S293 2.9854249
100S:S:W295 5.17609
101S:S:N300 4.324297
102S:S:N301 4.13754296
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F12 S:S:I29 41.16343.77YesYes014
2S:S:F116 S:S:I29 39.57497.54YesYes074
3R:R:F12 S:S:P117 44.54487.22YesNo014
4S:S:F116 S:S:T114 29.71433.89YesNo077
5R:R:F38 S:S:T114 29.48012.59YesNo077
6R:R:F38 R:R:L41 26.37982.44YesNo075
7R:R:L41 R:R:V109 14.5852.98NoYes055
8R:R:V109 S:S:L41 12.19782.98YesNo055
9S:S:F38 S:S:L41 26.37982.44YesNo075
10R:R:T114 S:S:F38 29.48012.59NoYes077
11R:R:F116 R:R:T114 29.71433.89YesNo077
12R:R:L41 S:S:V109 12.19782.98NoYes055
13S:S:L41 S:S:V109 14.5852.98NoYes055
14R:R:F116 R:R:I29 39.57497.54YesYes074
15R:R:I29 S:S:F12 41.16343.77YesYes041
16R:R:P117 S:S:F12 44.54487.22NoYes041
17R:R:P117 R:R:V196 44.95911.77NoYes041
18R:R:V196 R:R:Y111 50.32382.52YesNo015
19R:R:Y106 R:R:Y111 50.05095.96NoNo855
20R:R:Y106 R:R:Y128 52.76033.97NoYes858
21R:R:Y101 R:R:Y128 53.99037.94YesYes068
22R:R:Y101 R:R:Y98 55.74116.95YesYes066
23S:S:P117 S:S:V196 44.95911.77NoYes041
24S:S:V196 S:S:Y111 50.32382.52YesNo015
25S:S:Y106 S:S:Y111 50.05094.96NoNo1055
26S:S:Y106 S:S:Y128 52.76033.97NoYes1058
27S:S:Y101 S:S:Y128 53.99037.94YesYes068
28S:S:Y101 S:S:Y98 55.74116.95YesYes066
29S:S:F55 S:S:Y98 57.044625.79YesYes266
30S:S:F55 S:S:R58 54.97638.55YesYes269
31S:S:L283 S:S:R58 34.91277.29NoYes089
32S:S:L283 S:S:L287 35.13644.15NoYes088
33R:R:L64 S:S:L287 34.78912.77YesYes1358
34R:R:L64 R:R:V68 86.52631.49YesNo057
35R:R:V68 S:S:V68 86.47136.41NoNo077
36S:S:L64 S:S:V68 86.52631.49YesNo057
37R:R:L287 S:S:L64 34.78912.77YesYes1485
38R:R:L283 R:R:L287 35.13644.15NoYes088
39R:R:L283 R:R:R58 34.91277.29NoYes089
40R:R:F55 R:R:Y98 57.044625.79YesYes166
41R:R:H94 R:R:R58 16.11943.39YesYes189
42R:R:T65 S:S:L64 51.61365.9NoYes1475
43R:R:L88 R:R:T65 51.87842.95YesNo097
44R:R:A62 R:R:L88 29.97193.15NoYes089
45R:R:A62 R:R:I91 29.28873.25NoYes087
46R:R:L88 R:R:V286 31.92142.98YesNo098
47R:R:I91 R:R:V286 29.10454.61YesNo078
48R:R:I91 R:R:R58 56.24753.76YesYes079
49R:R:R58 R:R:T282 17.30652.59YesNo095
50R:R:L66 R:R:L88 1002.77NoYes059
51R:R:L66 R:R:Q85 96.99986.65NoYes755
52R:R:M69 R:R:Q85 95.367712.23NoYes785
53R:R:M69 R:R:P290 95.34993.35NoNo089
54R:R:N84 R:R:P290 94.83953.26YesNo099
55R:R:N84 R:R:S293 86.74112.98YesYes1699
56R:R:H94 R:R:Q135 16.97626.18YesNo086
57R:R:Q135 R:R:Y181 16.28582.25NoYes067
58R:R:F262 R:R:T282 14.60272.59YesNo075
59R:R:Q149 R:R:S293 86.12254.33YesYes099
60R:R:M218 R:R:Q149 54.20518.16YesYes089
61R:R:Q149 R:R:S292 32.27754.33YesNo099
62R:R:I150 R:R:M218 21.93484.37YesYes088
63R:R:I150 R:R:V221 10.65774.61YesNo087
64R:R:F217 R:R:L166 13.32924.87YesNo067
65R:R:L222 R:R:M218 26.4885.65YesYes098
66R:R:L222 R:R:W295 50.03234.56YesYes099
67R:R:K225 R:R:W295 20.003910.44NoYes099
68R:R:L222 R:R:S292 26.15043YesNo099
69R:R:L226 R:R:W295 10.78853.42NoYes099
70R:R:L248 R:R:W295 13.36559.11NoYes089
71R:R:F244 R:R:L248 10.68847.31NoNo398
72R:R:L255 R:R:P258 11.07933.28NoYes099
73S:S:I91 S:S:R58 56.24753.76YesYes079
74S:S:R58 S:S:T282 17.30652.59YesNo095
75S:S:A62 S:S:I91 29.28873.25NoYes087
76S:S:A62 S:S:L88 29.97193.15NoYes089
77S:S:I91 S:S:V286 29.10454.61YesNo078
78S:S:L88 S:S:V286 31.92142.98YesNo098
79S:S:L66 S:S:L88 1002.77NoYes059
80S:S:L66 S:S:Q85 96.99986.65NoYes955
81S:S:M69 S:S:Q85 95.367712.23NoYes985
82S:S:M69 S:S:P290 95.34993.35NoNo089
83S:S:N84 S:S:P290 94.83953.26YesNo099
84S:S:N84 S:S:S293 86.74112.98YesYes2499
85S:S:H94 S:S:Q135 16.97626.18YesNo086
86S:S:Q135 S:S:Y181 16.28582.25NoYes067
87S:S:F262 S:S:T282 14.60272.59YesNo075
88S:S:Q149 S:S:S293 86.12254.33YesYes099
89S:S:M218 S:S:Q149 54.20518.16YesYes089
90S:S:Q149 S:S:S292 32.27754.33YesNo099
91S:S:I150 S:S:M218 21.93484.37YesYes088
92S:S:I150 S:S:V221 10.65774.61YesNo087
93S:S:F217 S:S:L166 13.32924.87YesNo067
94S:S:L222 S:S:M218 26.4885.65YesYes098
95S:S:L222 S:S:W295 50.03234.56YesYes099
96S:S:K225 S:S:W295 20.003910.44NoYes099
97S:S:L222 S:S:S292 26.15043YesNo099
98S:S:L226 S:S:W295 10.78853.42NoYes099
99S:S:L248 S:S:W295 13.36559.11NoYes089
100S:S:F244 S:S:L248 10.68847.31NoNo498
101S:S:L255 S:S:P258 11.07933.28NoYes099
102R:R:F55 R:R:R58 54.97638.55YesYes169
103R:R:L64 S:S:T65 51.61365.9YesNo1357
104S:S:L88 S:S:T65 51.87842.95YesNo097
105S:S:H94 S:S:R58 16.11943.39YesYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7QB9
Class D1
SubFamily Ste2-like
Type STE2
SubType STE2
Species Saccharomyces cerevisiae
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.1
Date 2022-03-16
D.O.I. 10.1038/s41586-022-04498-3
Net Summary
Imin 1.77
Number of Linked Nodes 548
Number of Links 635
Number of Hubs 102
Number of Links mediated by Hubs 382
Number of Communities 30
Number of Nodes involved in Communities 134
Number of Links involved in Communities 158
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 320000
Length Of Smallest Path 3
Average Path Length 22.3453
Length of Longest Path 41
Minimum Path Strength 1.38
Average Path Strength 5.10543
Maximum Path Strength 21.05
Minimum Path Correlation 0.7
Average Path Correlation 0.959963
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 44.5112
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.7727
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP0CI39
Sequence
>7QB9_Chain_R
APSLSNLFY DPTYNPGQS TINYTSIYG NGSTITFDE LQGLVNSTV 
TQAIMFGVR CGAAALTLI VMWMTSRSR KTPIFIINQ VSLFLIILH 
SALYFKYLL SNYSSVTYA LTGFPQFIS RGDVHVYGA TNIIQVLLV 
ASIETSLVF QIKVIFTGD NFKRIGLML TSISFTLGI ATVTMYFVS 
AVKGMIVTY NDVSATQDK YFNASTILL ASSINFMSF VLVVKLILA 
IRSRRFLGL KQFDSFHIL LIMSCQSLL VPSIIFILA YSLKPNQGT 
DVLTTVATL LAVLSLPLS SMWATAANN AS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP0CI39
Sequence
>7QB9_Chain_S
APSLSNLFY DPTYNPGQS TINYTSIYG NGSTITFDE LQGLVNSTV 
TQAIMFGVR CGAAALTLI VMWMTSRSR KTPIFIINQ VSLFLIILH 
SALYFKYLL SNYSSVTYA LTGFPQFIS RGDVHVYGA TNIIQVLLV 
ASIETSLVF QIKVIFTGD NFKRIGLML TSISFTLGI ATVTMYFVS 
AVKGMIVTY NDVSATQDK YFNASTILL ASSINFMSF VLVVKLILA 
IRSRRFLGL KQFDSFHIL LIMSCQSLL VPSIIFILA YSLKPNQGT 
DVLTTVATL LAVLSLPLS SMWATAANN AS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7AD3D1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone-Gi1/STE4/&γ;23.32020-12-0910.1038/s41586-020-2994-1
7QA8D1Ste2-likeSTE2STE2Saccharomyces cerevisiaePeptide--2.72022-03-1610.1038/s41586-022-04498-3
7QB9D1Ste2-likeSTE2STE2Saccharomyces cerevisiae---3.12022-03-1610.1038/s41586-022-04498-3
7QBCD1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone--3.532022-03-1610.1038/s41586-022-04498-3
7QBID1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone--3.462022-03-1610.1038/s41586-022-04498-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7QB9.zip



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